EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23372428	Detection of hypermethylated spastic paraplegia-20 in stool samples of patients with colorectal cancer.	Int J Med Sci	2013	Zhang H	doi: 10.7150/ijms.5278
24381142	Detection of aberrant hypermethylated spastic paraplegia-20 as a potential biomarker and prognostic factor in gastric cancer.	Med Oncol	2014 Feb	Zhang H	doi: 10.1007/s12032-013-0830-2
21499309	SPG20, a novel biomarker for early detection of colorectal cancer, encodes a regulator of cytokinesis.	Oncogene	2011 Sep 15	Lind GE	doi: 10.1038/onc.2011.109
25942454	Chromosome mis-segregation and cytokinesis failure in trisomic human cells.	Elife	2015 May 5	Nicholson JM	doi: 10.7554/eLife.05068.
29673586	Methylation-induced silencing of SPG20 facilitates gastric cancer cell proliferation by activating the EGFR/MAPK pathway.	Biochem Biophys Res Commun	2018 Jun 2	Zhou Z	doi: 10.1016/j.bbrc.2018.04.089

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr13	36331441	Silent	novel	L322L	0.12
BLCA	chr13	36335162	Silent	novel	L223L	0.22
BLCA	chr13	36326695	Missense_Mutation	rs773279542	K390E	0.11
BLCA	chr13	36314228	Splice_Region	novel	L494L	0.39
BLCA	chr13	36335247	Nonsense_Mutation	novel	S195*	0.36
BLCA	chr13	36335061	Missense_Mutation	NA	S257C	0.25
BLCA	chr13	36329432	Missense_Mutation	novel	S365C	0.25
BLCA	chr13	36304494	Silent	novel	L624L	0.16
BLCA	chr13	36329363	Missense_Mutation	novel	R388K	0.16
BLCA	chr13	36335020	Splice_Site	NA	X270_splice	0.38
BRCA	chr13	36304363	3'UTR	novel		0.24
BRCA	chr13	36335823	Missense_Mutation	NA	Q3P	0.21
BRCA	chr13	36314360	Missense_Mutation	novel	Q450H	0.1
BRCA	chr13	36312338	Silent	NA	V541V	0.32
BRCA	chr13	36312419	Silent	NA	K514K	0.47
BRCA	chr13	36329462	Missense_Mutation	NA	R355T	0.51
BRCA	chr13	36326438	Intron	novel		0.44
BRCA	chr13	36331471	Silent	NA	S312S	0.37
BRCA	chr13	36312391	Missense_Mutation	NA	S524P	0.28
CESC	chr13	36304380	Silent	NA	K662K	0.41
CESC	chr13	36312379	Missense_Mutation	NA	D528Y	0.44
CESC	chr13	36335728	Missense_Mutation	NA	E35K	0.21
COAD	chr13	36335548	Missense_Mutation	NA	L95I	0.09
COAD	chr13	36312448	Missense_Mutation	rs778801809	V505I	0.55
COAD	chr13	36335205	Missense_Mutation	rs766680187	P209L	0.31
COAD	chr13	36335719	Missense_Mutation	novel	Q38K	0.05
COAD	chr13	36335346	Missense_Mutation	novel	P162Q	0.15
COAD	chr13	36304401	Silent	NA	T655T	0.3
COAD	chr13	36335041	Missense_Mutation	rs747665041	R264C	0.19
COAD	chr13	36331555	Silent	rs571222120	P284P	0.61
COAD	chr13	36314255	Silent	novel	G485G	0.28
COAD	chr13	36304548	Missense_Mutation	novel	N606K	0.42
COAD	chr13	36312448	Missense_Mutation	rs778801809	V505I	0.19
COAD	chr13	36326557	Intron	novel		0.31
COAD	chr13	36326632	Missense_Mutation	NA	E411Q	0.11
COAD	chr13	36312385	Nonsense_Mutation	NA	K526*	0.18
COAD	chr13	36335390	Silent	novel	T147T	0.09
COAD	chr13	36312439	Nonsense_Mutation	NA	E508*	0.08
COAD	chr13	36312419	Silent	NA	K514K	0.04
COAD	chr13	36335085	Missense_Mutation	NA	R249Q	0.23
COAD	chr13	36304254	3'UTR	rs558429279		0.09
COAD	chr13	36312449	Silent	rs376411341	C504C	0.29
COAD	chr13	36331448	Missense_Mutation	novel	R320I	0.32
COAD	chr13	36331487	Missense_Mutation	novel	V307A	0.39
COAD	chr13	36335242	Missense_Mutation	NA	V197I	0.17
COAD	chr13	36304402	Frame_Shift_Del	NA	*T655Rfs4**	0.63
COAD	chr13	36329457	Missense_Mutation	NA	S357A	0.24
COAD	chr13	36329462	Missense_Mutation	novel	R355I	0.35
COAD	chr13	36312188	Missense_Mutation	novel	V564I	0.66
ESCA	chr13	36335390	Silent	novel	T147T	0.27
ESCA	chr13	36335086	Nonsense_Mutation	rs776372801	R249*	0.34
ESCA	chr13	36326692	Missense_Mutation	NA	D391Y	0.22
ESCA	chr13	36303809	3'UTR	novel		0.26
ESCA	chr13	36326621	Missense_Mutation	NA	K414N	0.13
GBM	chr13	36314261	Silent	novel	A483A	0.27
HNSC	chr13	36335148	Missense_Mutation	NA	V228A	0.21
HNSC	chr13	36326548	Intron	novel		0.23
HNSC	chr13	36326549	Intron	NA		0.23
HNSC	chr13	36335603	Missense_Mutation	rs774657699	Q76H	0.52
KIRC	chr13	36304217	3'UTR	novel		0.29
KIRC	chr13	36331499	Missense_Mutation	novel	A303V	0.27
KIRC	chr13	36335756	Frame_Shift_Del	novel	*L25Ffs7**	0.32
LAML	chr13	36335122	Missense_Mutation	novel	G237R	0.04
LGG	chr13	36335135	Frame_Shift_Del	rs778573943	*F232Lfs2**	0.42
LGG	chr13	36312193	Missense_Mutation	novel	C562Y	0.21
LGG	chr13	36335193	Missense_Mutation	novel	T213I	0.43
LGG	chr13	36314375	Silent	novel	T445T	0.29
LGG	chr13	36335143	Frame_Shift_Ins	novel	*I230Lfs6**	0.11
LGG	chr13	36335144	In_Frame_Ins	novel	I230_F231insMI	0.11
LIHC	chr13	36331598	Splice_Site	novel	X271_splice	0.33
LUAD	chr13	36314373	Missense_Mutation	novel	G446V	0.13
LUAD	chr13	36335162	Missense_Mutation	novel	L223F	0.09
LUAD	chr13	36335815	Missense_Mutation	NA	Q6E	0.46
LUAD	chr13	36326519	Intron	novel		0.69
LUAD	chr13	36326577	Missense_Mutation	NA	S429L	0.43
LUAD	chr13	36326526	Intron	novel		0.43
LUAD	chr13	36335543	Missense_Mutation	NA	E96D	0.25
LUAD	chr13	36335413	Nonsense_Mutation	NA	E140*	0.3
LUAD	chr13	36304361	3'UTR	novel		0.19
LUAD	chr13	36329394	Missense_Mutation	novel	D378Y	0.16
LUAD	chr13	36301821	3'UTR	novel		0.57
LUSC	chr13	36326649	Missense_Mutation	novel	C405F	0.57
LUSC	chr13	36335635	Missense_Mutation	NA	H66D	0.46
LUSC	chr13	36304630	Missense_Mutation	NA	Y579S	0.85
LUSC	chr13	36335422	Nonsense_Mutation	NA	Q137*	0.33
LUSC	chr13	36304595	Missense_Mutation	novel	V591L	0.59
LUSC	chr13	36304596	Silent	novel	A590A	0.55
LUSC	chr13	36312355	Missense_Mutation	novel	D536N	0.78
LUSC	chr13	36335051	Silent	novel	T260T	0.17
LUSC	chr13	36312209	Nonsense_Mutation	NA	E557*	0.62
LUSC	chr13	36312344	Missense_Mutation	novel	M539I	0.12
PAAD	chr13	36326547	Intron	novel		0.17
PAAD	chr13	36312178	Missense_Mutation	novel	V567A	0.23
PAAD	chr13	36304228	3'UTR	novel		0.14
PAAD	chr13	36304229	3'UTR	novel		0.05
PAAD	chr13	36304541	Missense_Mutation	rs751799377	I609V	0.13
PAAD	chr13	36304608	Silent	rs759611560	A586A	0.2
PAAD	chr13	36326658	Missense_Mutation	novel	I402T	0.14
PAAD	chr13	36331597	Splice_Site	novel	X271_splice	0.21
PRAD	chr13	36312430	Missense_Mutation	NA	P511S	0.13
READ	chr13	36335110	Missense_Mutation	NA	A241T	0.34
READ	chr13	36314340	Missense_Mutation	rs748475972	R457Q	0.11
READ	chr13	36312449	Silent	rs376411341	C504C	0.34
READ	chr13	36304385	Missense_Mutation	NA	A661S	0.19
READ	chr13	36335056	Missense_Mutation	NA	D259N	0.44
READ	chr13	36329493	Nonsense_Mutation	NA	E345*	0.18
READ	chr13	36304414	Missense_Mutation	NA	K651T	0.07
READ	chr13	36304390	Missense_Mutation	novel	K659R	0.49
READ	chr13	36304272	3'UTR	novel		0.37
READ	chr13	36304628	Missense_Mutation	novel	G580R	0.39
SKCM	chr13	36314411	Missense_Mutation	novel	W433C	0.56
SKCM	chr13	36326605	Missense_Mutation	novel	S420G	0.21
SKCM	chr13	36335165	Silent	NA	I222I	0.27
SKCM	chr13	36335652	Missense_Mutation	NA	S60L	0.45
SKCM	chr13	36335035	Missense_Mutation	novel	P266S	0.08
SKCM	chr13	36314399	Silent	NA	G437G	0.12
SKCM	chr13	36335274	Missense_Mutation	NA	S186F	0.34
SKCM	chr13	36326554	Intron	novel		1
SKCM	chr13	36312360	Missense_Mutation	novel	P534L	0.4
STAD	chr13	36314340	Missense_Mutation	rs748475972	R457Q	0.19
STAD	chr13	36329494	Missense_Mutation	NA	E344D	0.12
STAD	chr13	36335135	Frame_Shift_Del	rs778573943	*F232Lfs2**	0.16
STAD	chr13	36314268	Missense_Mutation	NA	K481T	0.16
STAD	chr13	36314335	Missense_Mutation	NA	R459W	0.31
STAD	chr13	36331429	Silent	NA	L326L	0.22
STAD	chr13	36304585	Missense_Mutation	NA	A594E	0.18
STAD	chr13	36335135	Frame_Shift_Del	rs778573943	*F232Lfs2**	0.31
STAD	chr13	36304402	Missense_Mutation	rs140800614	T655M	0.28
STAD	chr13	36335126	Silent	novel	P235P	0.06
STAD	chr13	36335271	Missense_Mutation	rs375284717	Y187C	0.68
STAD	chr13	36314319	Missense_Mutation	NA	E464G	0.24
STAD	chr13	36335708	Missense_Mutation	rs749355386	E41D	0.4
STAD	chr13	36335032	Missense_Mutation	rs780508028	G267R	0.18
STAD	chr13	36335289	Frame_Shift_Del	novel	*G181Vfs34**	0.21
STAD	chr13	36314288	Silent	NA	T474T	0.23
STAD	chr13	36335301	Missense_Mutation	NA	Q177R	0.25
STAD	chr13	36335135	Frame_Shift_Del	rs778573943	*F232Lfs2**	0.16
STAD	chr13	36314370	Missense_Mutation	novel	K447T	0.2
STAD	chr13	36335148	Missense_Mutation	NA	V228A	0.54
STAD	chr13	36326650	Missense_Mutation	rs748804234	C405R	0.2
STAD	chr13	36335135	Frame_Shift_Del	rs778573943	*F232Lfs2**	0.14
STAD	chr13	36335134	Frame_Shift_Ins	rs770560051	*V233Cfs8**	0.29
STAD	chr13	36335811	Frame_Shift_Del	novel	*N7Mfs25**	0.29
STAD	chr13	36329477	Missense_Mutation	novel	I350N	0.35
STAD	chr13	36331452	Missense_Mutation	NA	D319Y	0.21
STAD	chr13	36304272	3'UTR	novel		0.19
STAD	chr13	36304386	Silent	NA	E660E	0.25
THCA	chr13	36331405	Silent	novel	R334R	0.41
UCEC	chr13	36331507	Silent	NA	L300L	0.18
UCEC	chr13	36326447	Intron	novel		0.27
UCEC	chr13	36329439	Nonsense_Mutation	NA	E363*	0.36
UCEC	chr13	36335743	Missense_Mutation	novel	G30C	0.05
UCEC	chr13	36312373	Missense_Mutation	NA	D530Y	0.4
UCEC	chr13	36335168	Missense_Mutation	NA	L221F	0.33
UCEC	chr13	36335329	Missense_Mutation	NA	A168T	0.44
UCEC	chr13	36312394	Nonsense_Mutation	NA	E523*	0.44
UCEC	chr13	36335290	Missense_Mutation	novel	G181C	0.35
UCEC	chr13	36335702	Silent	novel	K43K	0.21
UCEC	chr13	36304479	Missense_Mutation	rs148027828	Q629H	0.16
UCEC	chr13	36335085	Missense_Mutation	NA	R249Q	0.13
UCEC	chr13	36303995	3'UTR	novel		0.57
UCEC	chr13	36331515	Missense_Mutation	novel	T298A	0.19
UCEC	chr13	36335223	Missense_Mutation	novel	R203K	0.3
UCEC	chr13	36303926	3'UTR	novel		0.32
UCEC	chr13	36304282	3'UTR	novel		0.12
UCEC	chr13	36312384	Missense_Mutation	novel	K526T	0.09
UCEC	chr13	36326447	Intron	novel		0.47
UCEC	chr13	36335702	Missense_Mutation	novel	K43N	0.29
UCEC	chr13	36304038	3'UTR	novel		0.23
UCEC	chr13	36304529	Missense_Mutation	rs574448043	V613M	0.31
UCEC	chr13	36304298	3'UTR	novel		0.11
UCEC	chr13	36304546	Missense_Mutation	novel	I607T	0.12
UCEC	chr13	36303719	3'UTR	novel		0.31
UCEC	chr13	36329439	Nonsense_Mutation	NA	E363*	0.34
UCEC	chr13	36335573	Missense_Mutation	novel	Q86H	0.43
UCEC	chr13	36335298	Missense_Mutation	novel	A178V	0.45
UCEC	chr13	36335134	Frame_Shift_Ins	rs770560051	*V233Cfs8**	0.44
UCEC	chr13	36304197	3'UTR	novel		0.33
UCEC	chr13	36335102	Silent	novel	S243S	0.47
UCEC	chr13	36329447	Missense_Mutation	rs200205969	Q360R	0.37
UCEC	chr13	36335151	Missense_Mutation	NA	G227V	0.29
UCEC	chr13	36335204	Silent	rs370385005	P209P	0.48
UCEC	chr13	36326478	Intron	novel		0.31
UCEC	chr13	36304369	Missense_Mutation	NA	K666T	0.14
UCEC	chr13	36335765	Missense_Mutation	rs142586662	K22N	0.15
UCEC	chr13	36335385	Missense_Mutation	novel	S149N	0.43
UCEC	chr13	36335813	Missense_Mutation	novel	Q6H	0.46
UCEC	chr13	36303854	3'UTR	novel		0.33
UCEC	chr13	36304278	3'UTR	novel		0.27
UCEC	chr13	36314271	Missense_Mutation	rs750885553	A480V	0.37
UCEC	chr13	36326620	Nonsense_Mutation	novel	E415*	0.33
UCEC	chr13	36331422	Nonsense_Mutation	novel	Q329*	0.28
UCEC	chr13	36335702	Missense_Mutation	novel	K43N	0.39
UCEC	chr13	36335135	Frame_Shift_Del	rs778573943	*F232Lfs2**	0.3
UCEC	chr13	36303840	3'UTR	novel		0.11
UCEC	chr13	36335085	Missense_Mutation	NA	R249Q	0.25
UCEC	chr13	36314256	Missense_Mutation	novel	G485E	0.28
UCEC	chr13	36326565	Intron	novel		0.26
UCEC	chr13	36335135	Frame_Shift_Del	rs778573943	*F232Lfs2**	0.28
UCEC	chr13	36329387	Missense_Mutation	NA	R380H	0.08
UCEC	chr13	36326586	Missense_Mutation	NA	N426S	0.36
UCEC	chr13	36303703	3'UTR	novel		0.5
UCEC	chr13	36304493	Missense_Mutation	novel	L625I	0.08
UCEC	chr13	36326667	Missense_Mutation	novel	L399P	0.25
UCEC	chr13	36303782	3'UTR	novel		0.23
UCEC	chr13	36335190	Missense_Mutation	novel	L214S	0.25
UCEC	chr13	36303906	3'UTR	novel		0.29
UCEC	chr13	36312439	Nonsense_Mutation	NA	E508*	0.35
UCEC	chr13	36335135	Frame_Shift_Del	rs778573943	*F232Lfs2**	0.38
UCEC	chr13	36335056	Missense_Mutation	NA	D259N	0.26
UCEC	chr13	36304548	Silent	novel	N606N	0.52
UCEC	chr13	36304619	Missense_Mutation	novel	A583T	0.27
UCEC	chr13	36314335	Missense_Mutation	NA	R459W	0.25
UCEC	chr13	36335102	Silent	rs752668390	S243S	0.28
UCEC	chr13	36326532	Intron	novel		0.29
UCEC	chr13	36331503	Missense_Mutation	NA	A302T	0.31
UCEC	chr13	36314334	Missense_Mutation	rs7321457	R459Q	0.31
UCEC	chr13	36335135	Frame_Shift_Del	rs778573943	*F232Lfs2**	0.24
UCEC	chr13	36303993	3'UTR	novel		0.42
UCEC	chr13	36335204	Silent	rs370385005	P209P	0.41

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
COAD	DEL	0.02	0.24773
KIRC	DEL	0.1193	0.031318
MESO	DEL	0.4253	0.0010209

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00014	Kaplan-Meier Survival Analysis
MESO	0.00062	Kaplan-Meier Survival Analysis
HNSC	0.038	Kaplan-Meier Survival Analysis
BRCA	0.027	Kaplan-Meier Survival Analysis
LAML	0.0094	Kaplan-Meier Survival Analysis
GBM	0.036	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000133104 (Gene tree)
Gene ID: 23111
Gene Symbol: SPART
Alias: KIAA0610|TAHCCP1|SPG20
Full Name: spartin
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 68,543 bases
Position: chr13:36,301,638-36,370,180
Accession: 18514
RBP type: non-canonical RBP
Summary: This gene encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome). [provided by RefSeq, Nov 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000438666	SPART-202	4789	XM_005266313	ENSP00000406061	666 (aa)	XP_005266370	Q8N0X7
ENST00000495510	SPART-211	2001	-	-	- (aa)	-	-
ENST00000650221	SPART-212	4881	-	ENSP00000497209	666 (aa)	-	A0A024RDV9
ENST00000460126	SPART-204	392	-	-	- (aa)	-	-
ENST00000355182	SPART-201	4820	-	ENSP00000347314	666 (aa)	-	Q8N0X7
ENST00000491805	SPART-208	668	-	-	- (aa)	-	-
ENST00000482146	SPART-207	583	-	-	- (aa)	-	-
ENST00000494062	SPART-209	3018	XM_005266315	ENSP00000473599	666 (aa)	XP_005266372	Q8N0X7
ENST00000476377	SPART-206	362	-	-	- (aa)	-	-
ENST00000451493	SPART-203	4944	XM_005266314	ENSP00000414147	666 (aa)	XP_005266371	Q8N0X7
ENST00000494703	SPART-210	796	-	-	- (aa)	-	-
ENST00000475603	SPART-205	675	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000133104's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04144	Endocytosis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000133104	Waist Circumference	3.2390000E-005	-
ENSG00000133104	Platelet Function Tests	2.6934900E-005	-
ENSG00000133104	Language Tests	1.9392000E-005	-
ENSG00000133104	Child Development Disorders, Pervasive	7.4020000E-006	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000133104's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	20719964.	IPI	Function
GO:0005737	cytoplasm	19580544.	IDA	Component
GO:0005741	mitochondrial outer membrane	21559443.	IDA	Component
GO:0005811	lipid droplet	-	IEA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005886	plasma membrane	21873635.	IBA	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0009838	abscission	20719964.	IMP	Process
GO:0030496	midbody	20719964.	IDA	Component
GO:0030514	negative regulation of BMP signaling pathway	21873635.	IBA	Process
GO:0031625	ubiquitin protein ligase binding	19580544.	IPI	Function
GO:0034389	lipid droplet organization	-	IEA	Process
GO:0045202	synapse	-	IEA	Component
GO:0048698	negative regulation of collateral sprouting in absence of injury	-	IEA	Process
GO:0050905	neuromuscular process	-	IEA	Process
GO:0051301	cell division	21873635.	IBA	Process
GO:0051301	cell division	20719964.	IMP	Process
GO:0051881	regulation of mitochondrial membrane potential	21559443.	IMP	Process
GO:0060612	adipose tissue development	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.