EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
22902387miR-27b-regulated TCTP as a novel plasma biomarker for oral cancer: from quantitative proteomics to post-transcriptional study.J Proteomics2012 Dec 21Lo WYdoi: 10.1016/j.jprot.2012.07.039
28536478HpSlyD inducing CDX2 and VIL1 expression mediated through TCTP protein may contribute to intestinal metaplasia in the stomach.Sci Rep2017 May 23Li Qdoi: 10.1038/s41598-017-02642-y.
25263704Osteoclastogenic activity of translationally-controlled tumor protein (TCTP) with reciprocal repression of p21.FEBS Lett2014 Nov 3Choi SWdoi: 10.1016/j.febslet.2014.09.022
26425551Expression of Translationally Controlled Tumor Protein in Human Kidney and in Renal Cell Carcinoma.Biomed Res Int2015Ambrosio MRdoi: 10.1155/2015/730390
24606760Interaction of translationally controlled tumor protein with Apaf-1 is involved in the development of chemoresistance in HeLa cells.BMC Cancer2014 Mar 7Jung Jdoi: 10.1186/1471-2407-14-165.
23749504TCTP overexpression is associated with the development and progression of glioma.Tumour Biol2013 DecMiao Xdoi: 10.1007/s13277-013-0906-9
11991642The mRNA of the translationally controlled tumor protein P23/TCTP is a highly structured RNA, which activates the dsRNA-dependent protein kinase PKR.RNA2002 AprBommer UA-
17897616Solution structure and mapping of a very weak calcium-binding site of human translationally controlled tumor protein by NMR.Arch Biochem Biophys2007 Nov 1Feng Y-
12399545Biological models and genes of tumor reversion: cellular reprogramming through tpt1/TCTP and SIAH-1.Proc Natl Acad Sci U S A2002 Nov 12Tuynder M-
24106833Identification of stage-specific breast markers using quantitative proteomics.J Proteome Res2013 Dec 6Shaheed SUdoi: 10.1021/pr400662k
23894469TCTP is an androgen-regulated gene implicated in prostate cancer.PLoS One2013 Jul 22Kaarb Mdoi: 10.1371/journal.pone.0069398
21801721TCTP is a critical survival factor that protects cancer cells from oxidative stress-induced cell-death.Exp Cell Res2011 Oct 15Lucibello Mdoi: 10.1016/j.yexcr.2011.07.012
25779659Phospho-TCTP as a therapeutic target of Dihydroartemisinin for aggressive breast cancer cells.Oncotarget2015 Mar 10Lucibello M-
19360337Gene silencing of translationally controlled tumor protein (TCTP) by siRNA inhibits cell growth and induces apoptosis of human prostate cancer cells.Int J Oncol2009 MayGnanasekar M-
17549383PAI-1 induces cell detachment, downregulates nucleophosmin (B23) and fortilin (TCTP) in LnCAP prostate cancer cells.Int J Mol Med2007 JulJankun J-
25423047Cellular uptake mechanism of TCTP-PTD in human lung carcinoma cells.Mol Pharm2015 Jan 5Kim HYdoi: 10.1021/mp500547f
22340241Proteomic analysis identifies translationally controlled tumor protein as a mediator of phosphatase of regenerating liver-3-promoted proliferation, migration and invasion in human colon cancer cells.Chin Med J (Engl)2011 NovChu ZH-
23042265Inverse relationship between TCTP/RhoA and p53 /cyclin A/actin expression in ovarian cancer cells.Folia Histochem Cytobiol2012 Oct 8Kloc Mdoi: 10.5603/19745.
28143584Translationally controlled tumour protein TCTP is induced early in human colorectal tumours and contributes to the resistance of HCT116 colon cancer cells to 5-FU and oxaliplatin.Cell Commun Signal2017 Feb 1Bommer UAdoi: 10.1186/s12964-017-0164-3.
27367023Extracellular translationally controlled tumor protein promotes colorectal cancer invasion and metastasis through Cdc42/JNK/ MMP9 signaling.Oncotarget2016 Aug 2Xiao Bdoi: 10.18632/oncotarget.10315.
28472637Lipid-oligonucleotide conjugates improve cellular uptake and efficiency of TCTP-antisense in castration-resistant prostate cancer.J Control Release2017 Jul 28Karaki Sdoi: 10.1016/j.jconrel.2017.04.042
30066846Translationally controlled tumor protein affects colorectal cancer metastasis through the high mobility group box 1-dependent pathway.Int J Oncol2018 OctHuang Mdoi: 10.3892/ijo.2018.4502

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1345338696Missense_MutationNAM160I0.25
BLCAchr1345340115Missense_MutationNAE58Q0.21
BLCAchr13453372953'UTRnovel0.14
BLCAchr1345340124Missense_MutationNAE55K0.17
BLCAchr1345341067Translation_Start_SitenovelM1?0.77
BRCAchr1345339576Missense_MutationNAR107T0.15
BRCAchr1345340003Missense_MutationnovelY95F0.07
BRCAchr1345340291Intronnovel0.35
COADchr13453372823'UTRnovel0.39
COADchr1345338662Frame_Shift_InsnovelC172Mfs*380.16
COADchr13453373703'UTRnovel0.13
COADchr1345337530Intronnovel0.38
ESCAchr1345340253Intronnovel0.29
KIRCchr1345340134SilentnovelN51N0.27
KIRCchr13453371853'UTRnovel0.67
KIRPchr1345339553Missense_MutationNAM115L0.23
KIRPchr1345337591Intronnovel0.32
LIHCchr13453411455'UTRnovel0.3
LIHCchr1345340785Missense_MutationnovelH10L0.48
LIHCchr13453411515'UTRnovel0.47
LUADchr1345340275Intronnovel0.33
LUSCchr13453411235'UTRnovel0.48
LUSCchr13453373263'UTRnovel0.2
OVchr1345340045Missense_MutationnovelT81R0.12
PRADchr1345339574Missense_MutationnovelP108S0.21
SKCMchr1345337535Intronnovel0.32
SKCMchr1345338751Missense_MutationNAP142L0.28
SKCMchr1345340031Missense_MutationNAE86K0.38
SKCMchr1345339555Missense_MutationNAF114C0.32
STADchr13453410735'UTRrs3771968860.15
STADchr1345340043Missense_MutationNAS82R0.34
STADchr1345337541Intronnovel0.21
STADchr1345339993Splice_SiteNAX98_splice0.14
STADchr13453411005'UTRnovel0.14
THCAchr1345340077SilentNAV70V0.08
UCECchr1345340331Intronnovel0.15
UCECchr1345340292IntronNA0.3
UCECchr1345340237Intronnovel0.19
UCECchr13453373393'UTRnovel0.17
UCECchr1345340189Splice_Regionrs5381455990.17
UCECchr1345340220Intronnovel0.17
UCECchr1345340468Intronnovel0.57
UCECchr1345337522IntronNA0.1
UCECchr1345338695Missense_MutationnovelI161F0.3
UCECchr1345337508Intronrs7717589410.56
UCECchr1345337609Intronnovel0.41
UCECchr13453371893'UTRnovel0.32
UCECchr1345340292IntronNA0.58
UCECchr1345340621Intronnovel0.36
UCECchr1345340177Missense_MutationNAS37I0.28
UCECchr1345340273Intronnovel0.37
UCECchr1345337584Intronnovel0.28
UCECchr1345341061Silentrs777636937I3I0.36

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
CESCDEL0.33562.1677e-19
COADDEL0.02660.24773
HNSCDEL0.35441.2142e-15
KIRCDEL0.11740.031318
MESODEL0.41380.0010209
PRADDEL0.39841.1439e-73

Survival Analysis
CancerP-value Q-value
MESO0.0008

Kaplan-Meier Survival Analysis

HNSC0.02

Kaplan-Meier Survival Analysis

SKCM0.015

Kaplan-Meier Survival Analysis

BRCA0.00017

Kaplan-Meier Survival Analysis

ESCA0.0035

Kaplan-Meier Survival Analysis

CESC0.037

Kaplan-Meier Survival Analysis

LAML0.019

Kaplan-Meier Survival Analysis

KICH0.048

Kaplan-Meier Survival Analysis

UCEC0.00011

Kaplan-Meier Survival Analysis

LIHC0.016

Kaplan-Meier Survival Analysis

LGG0.0008

Kaplan-Meier Survival Analysis

CHOL0.044

Kaplan-Meier Survival Analysis

THCA0.032

Kaplan-Meier Survival Analysis

OV0.0033

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000133112 (Gene tree)
Gene ID
7178
Gene Symbol
TPT1
Alias
TCTP|fortilin
Full Name
tumor protein, translationally-controlled 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
7,900 bases
Position
chr13:45,333,471-45,341,370
Accession
12022
RBP type
non-canonical RBP
Summary
This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including apoptosis, protein synthesis and cell division. It binds to and stabilizes microtubules, and removal of this protein through phosphorylation is required for progression through mitotic and meiotic cell divisions. This gene is known to play a role in carcinogenesis, and is upregulated in some cancer cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
17330940Altered chaperone and protein turnover regulators expression in cultured skin fibroblasts from type 1 diabetes mellitus with nephropathy.J Proteome Res2007 MarTessari P-
17894822Induction of translationally controlled tumor protein (TCTP) by transcriptional and post-transcriptional mechanisms.FEBS J2007 OctSchmidt I-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000616577TPT1-2144814-ENSP00000477781197 (aa)-A0A0B4J2C3
ENST00000490277TPT1-2071851--- (aa)--
ENST00000530705TPT1-2124735-ENSP00000431872172 (aa)-P13693
ENST00000527226TPT1-208613-ENSP00000433738162 (aa)-E9PJF7
ENST00000379055TPT1-202948-ENSP00000368344138 (aa)-P13693
ENST00000528619TPT1-209731-ENSP0000043309177 (aa)-H0YCX0
ENST00000379060TPT1-204764-ENSP00000368350160 (aa)-J3KPG2
ENST00000379056TPT1-2031101-ENSP00000368345138 (aa)-P13693
ENST00000442760TPT1-205902--- (aa)--
ENST00000309246TPT1-2011008-ENSP00000339051188 (aa)-Q5W0H4
ENST00000484604TPT1-206794--- (aa)--
ENST00000529421TPT1-210801--- (aa)--
ENST00000530245TPT1-211530-ENSP0000043245777 (aa)-H0YCX0
ENST00000533567TPT1-213594--- (aa)--
Gene Model
Click here to download ENSG00000133112's gene model file
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000133112's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000133112TPT110036.957WBGene00009122tct-110036.957Caenorhabditis_elegans
ENSG00000133112TPT110095.930ENSMUSG00000060126Tpt110095.930Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000922spindle pole15162379.IDAComponent
GO:0003723RNA binding22658674.HDAFunction
GO:0005509calcium ion binding21873635.IBAFunction
GO:0005509calcium ion binding15162379.15958728.IDAFunction
GO:0005515protein binding16730713.17301792.18325344.21081126.21278788.22451927.25277244.25416956.IPIFunction
GO:0005615extracellular space15319436.IDAComponent
GO:0005634nucleus11598139.IDAComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0005737cytoplasm15162379.IDAComponent
GO:0005737cytoplasm16130169.TASComponent
GO:0005771multivesicular body15319436.IDAComponent
GO:0005829cytosol-IDAComponent
GO:0005881cytoplasmic microtubule15162379.IDAComponent
GO:0006816calcium ion transport15958728.ICProcess
GO:0006874cellular calcium ion homeostasis15958728.ICProcess
GO:0009615response to virus16548883.IEPProcess
GO:0042981regulation of apoptotic process15162379.NASProcess
GO:0043066negative regulation of apoptotic process16130169.TASProcess
GO:0070062extracellular exosome23533145.HDAComponent
GO:1902230negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage11598139.IMPProcess
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