EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
22902387	miR-27b-regulated TCTP as a novel plasma biomarker for oral cancer: from quantitative proteomics to post-transcriptional study.	J Proteomics	2012 Dec 21	Lo WY	doi: 10.1016/j.jprot.2012.07.039
28536478	HpSlyD inducing CDX2 and VIL1 expression mediated through TCTP protein may contribute to intestinal metaplasia in the stomach.	Sci Rep	2017 May 23	Li Q	doi: 10.1038/s41598-017-02642-y.
25263704	Osteoclastogenic activity of translationally-controlled tumor protein (TCTP) with reciprocal repression of p21.	FEBS Lett	2014 Nov 3	Choi SW	doi: 10.1016/j.febslet.2014.09.022
26425551	Expression of Translationally Controlled Tumor Protein in Human Kidney and in Renal Cell Carcinoma.	Biomed Res Int	2015	Ambrosio MR	doi: 10.1155/2015/730390
24606760	Interaction of translationally controlled tumor protein with Apaf-1 is involved in the development of chemoresistance in HeLa cells.	BMC Cancer	2014 Mar 7	Jung J	doi: 10.1186/1471-2407-14-165.
23749504	TCTP overexpression is associated with the development and progression of glioma.	Tumour Biol	2013 Dec	Miao X	doi: 10.1007/s13277-013-0906-9
11991642	The mRNA of the translationally controlled tumor protein P23/TCTP is a highly structured RNA, which activates the dsRNA-dependent protein kinase PKR.	RNA	2002 Apr	Bommer UA	-
17897616	Solution structure and mapping of a very weak calcium-binding site of human translationally controlled tumor protein by NMR.	Arch Biochem Biophys	2007 Nov 1	Feng Y	-
12399545	Biological models and genes of tumor reversion: cellular reprogramming through tpt1/TCTP and SIAH-1.	Proc Natl Acad Sci U S A	2002 Nov 12	Tuynder M	-
24106833	Identification of stage-specific breast markers using quantitative proteomics.	J Proteome Res	2013 Dec 6	Shaheed SU	doi: 10.1021/pr400662k
23894469	TCTP is an androgen-regulated gene implicated in prostate cancer.	PLoS One	2013 Jul 22	Kaarb M	doi: 10.1371/journal.pone.0069398
21801721	TCTP is a critical survival factor that protects cancer cells from oxidative stress-induced cell-death.	Exp Cell Res	2011 Oct 15	Lucibello M	doi: 10.1016/j.yexcr.2011.07.012
25779659	Phospho-TCTP as a therapeutic target of Dihydroartemisinin for aggressive breast cancer cells.	Oncotarget	2015 Mar 10	Lucibello M	-
19360337	Gene silencing of translationally controlled tumor protein (TCTP) by siRNA inhibits cell growth and induces apoptosis of human prostate cancer cells.	Int J Oncol	2009 May	Gnanasekar M	-
17549383	PAI-1 induces cell detachment, downregulates nucleophosmin (B23) and fortilin (TCTP) in LnCAP prostate cancer cells.	Int J Mol Med	2007 Jul	Jankun J	-
25423047	Cellular uptake mechanism of TCTP-PTD in human lung carcinoma cells.	Mol Pharm	2015 Jan 5	Kim HY	doi: 10.1021/mp500547f
22340241	Proteomic analysis identifies translationally controlled tumor protein as a mediator of phosphatase of regenerating liver-3-promoted proliferation, migration and invasion in human colon cancer cells.	Chin Med J (Engl)	2011 Nov	Chu ZH	-
23042265	Inverse relationship between TCTP/RhoA and p53 /cyclin A/actin expression in ovarian cancer cells.	Folia Histochem Cytobiol	2012 Oct 8	Kloc M	doi: 10.5603/19745.
28143584	Translationally controlled tumour protein TCTP is induced early in human colorectal tumours and contributes to the resistance of HCT116 colon cancer cells to 5-FU and oxaliplatin.	Cell Commun Signal	2017 Feb 1	Bommer UA	doi: 10.1186/s12964-017-0164-3.
27367023	Extracellular translationally controlled tumor protein promotes colorectal cancer invasion and metastasis through Cdc42/JNK/ MMP9 signaling.	Oncotarget	2016 Aug 2	Xiao B	doi: 10.18632/oncotarget.10315.
28472637	Lipid-oligonucleotide conjugates improve cellular uptake and efficiency of TCTP-antisense in castration-resistant prostate cancer.	J Control Release	2017 Jul 28	Karaki S	doi: 10.1016/j.jconrel.2017.04.042
30066846	Translationally controlled tumor protein affects colorectal cancer metastasis through the high mobility group box 1-dependent pathway.	Int J Oncol	2018 Oct	Huang M	doi: 10.3892/ijo.2018.4502

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr13	45338696	Missense_Mutation	NA	M160I	0.25
BLCA	chr13	45340115	Missense_Mutation	NA	E58Q	0.21
BLCA	chr13	45337295	3'UTR	novel		0.14
BLCA	chr13	45340124	Missense_Mutation	NA	E55K	0.17
BLCA	chr13	45341067	Translation_Start_Site	novel	M1?	0.77
BRCA	chr13	45339576	Missense_Mutation	NA	R107T	0.15
BRCA	chr13	45340003	Missense_Mutation	novel	Y95F	0.07
BRCA	chr13	45340291	Intron	novel		0.35
COAD	chr13	45337282	3'UTR	novel		0.39
COAD	chr13	45338662	Frame_Shift_Ins	novel	*C172Mfs38**	0.16
COAD	chr13	45337370	3'UTR	novel		0.13
COAD	chr13	45337530	Intron	novel		0.38
ESCA	chr13	45340253	Intron	novel		0.29
KIRC	chr13	45340134	Silent	novel	N51N	0.27
KIRC	chr13	45337185	3'UTR	novel		0.67
KIRP	chr13	45339553	Missense_Mutation	NA	M115L	0.23
KIRP	chr13	45337591	Intron	novel		0.32
LIHC	chr13	45341145	5'UTR	novel		0.3
LIHC	chr13	45340785	Missense_Mutation	novel	H10L	0.48
LIHC	chr13	45341151	5'UTR	novel		0.47
LUAD	chr13	45340275	Intron	novel		0.33
LUSC	chr13	45341123	5'UTR	novel		0.48
LUSC	chr13	45337326	3'UTR	novel		0.2
OV	chr13	45340045	Missense_Mutation	novel	T81R	0.12
PRAD	chr13	45339574	Missense_Mutation	novel	P108S	0.21
SKCM	chr13	45337535	Intron	novel		0.32
SKCM	chr13	45338751	Missense_Mutation	NA	P142L	0.28
SKCM	chr13	45340031	Missense_Mutation	NA	E86K	0.38
SKCM	chr13	45339555	Missense_Mutation	NA	F114C	0.32
STAD	chr13	45341073	5'UTR	rs377196886		0.15
STAD	chr13	45340043	Missense_Mutation	NA	S82R	0.34
STAD	chr13	45337541	Intron	novel		0.21
STAD	chr13	45339993	Splice_Site	NA	X98_splice	0.14
STAD	chr13	45341100	5'UTR	novel		0.14
THCA	chr13	45340077	Silent	NA	V70V	0.08
UCEC	chr13	45340331	Intron	novel		0.15
UCEC	chr13	45340292	Intron	NA		0.3
UCEC	chr13	45340237	Intron	novel		0.19
UCEC	chr13	45337339	3'UTR	novel		0.17
UCEC	chr13	45340189	Splice_Region	rs538145599		0.17
UCEC	chr13	45340220	Intron	novel		0.17
UCEC	chr13	45340468	Intron	novel		0.57
UCEC	chr13	45337522	Intron	NA		0.1
UCEC	chr13	45338695	Missense_Mutation	novel	I161F	0.3
UCEC	chr13	45337508	Intron	rs771758941		0.56
UCEC	chr13	45337609	Intron	novel		0.41
UCEC	chr13	45337189	3'UTR	novel		0.32
UCEC	chr13	45340292	Intron	NA		0.58
UCEC	chr13	45340621	Intron	novel		0.36
UCEC	chr13	45340177	Missense_Mutation	NA	S37I	0.28
UCEC	chr13	45340273	Intron	novel		0.37
UCEC	chr13	45337584	Intron	novel		0.28
UCEC	chr13	45341061	Silent	rs777636937	I3I	0.36

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	DEL	0.3356	2.1677e-19
COAD	DEL	0.0266	0.24773
HNSC	DEL	0.3544	1.2142e-15
KIRC	DEL	0.1174	0.031318
MESO	DEL	0.4138	0.0010209
PRAD	DEL	0.3984	1.1439e-73

Survival Analysis

Cancer	P-value	Q-value
MESO	0.0008	Kaplan-Meier Survival Analysis
HNSC	0.02	Kaplan-Meier Survival Analysis
SKCM	0.015	Kaplan-Meier Survival Analysis
BRCA	0.00017	Kaplan-Meier Survival Analysis
ESCA	0.0035	Kaplan-Meier Survival Analysis
CESC	0.037	Kaplan-Meier Survival Analysis
LAML	0.019	Kaplan-Meier Survival Analysis
KICH	0.048	Kaplan-Meier Survival Analysis
UCEC	0.00011	Kaplan-Meier Survival Analysis
LIHC	0.016	Kaplan-Meier Survival Analysis
LGG	0.0008	Kaplan-Meier Survival Analysis
CHOL	0.044	Kaplan-Meier Survival Analysis
THCA	0.032	Kaplan-Meier Survival Analysis
OV	0.0033	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000133112 (Gene tree)
Gene ID: 7178
Gene Symbol: TPT1
Alias: TCTP|fortilin
Full Name: tumor protein, translationally-controlled 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 7,900 bases
Position: chr13:45,333,471-45,341,370
Accession: 12022
RBP type: non-canonical RBP
Summary: This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including apoptosis, protein synthesis and cell division. It binds to and stabilizes microtubules, and removal of this protein through phosphorylation is required for progression through mitotic and meiotic cell divisions. This gene is known to play a role in carcinogenesis, and is upregulated in some cancer cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
17330940	Altered chaperone and protein turnover regulators expression in cultured skin fibroblasts from type 1 diabetes mellitus with nephropathy.	J Proteome Res	2007 Mar	Tessari P	-
17894822	Induction of translationally controlled tumor protein (TCTP) by transcriptional and post-transcriptional mechanisms.	FEBS J	2007 Oct	Schmidt I	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000616577	TPT1-214	4814	-	ENSP00000477781	197 (aa)	-	A0A0B4J2C3
ENST00000490277	TPT1-207	1851	-	-	- (aa)	-	-
ENST00000530705	TPT1-212	4735	-	ENSP00000431872	172 (aa)	-	P13693
ENST00000527226	TPT1-208	613	-	ENSP00000433738	162 (aa)	-	E9PJF7
ENST00000379055	TPT1-202	948	-	ENSP00000368344	138 (aa)	-	P13693
ENST00000528619	TPT1-209	731	-	ENSP00000433091	77 (aa)	-	H0YCX0
ENST00000379060	TPT1-204	764	-	ENSP00000368350	160 (aa)	-	J3KPG2
ENST00000379056	TPT1-203	1101	-	ENSP00000368345	138 (aa)	-	P13693
ENST00000442760	TPT1-205	902	-	-	- (aa)	-	-
ENST00000309246	TPT1-201	1008	-	ENSP00000339051	188 (aa)	-	Q5W0H4
ENST00000484604	TPT1-206	794	-	-	- (aa)	-	-
ENST00000529421	TPT1-210	801	-	-	- (aa)	-	-
ENST00000530245	TPT1-211	530	-	ENSP00000432457	77 (aa)	-	H0YCX0
ENST00000533567	TPT1-213	594	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000133112's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000133112's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000133112	TPT1	100	36.957	WBGene00009122	tct-1	100	36.957	Caenorhabditis_elegans
ENSG00000133112	TPT1	100	95.930	ENSMUSG00000060126	Tpt1	100	95.930	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000922	spindle pole	15162379.	IDA	Component
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005509	calcium ion binding	21873635.	IBA	Function
GO:0005509	calcium ion binding	15162379.15958728.	IDA	Function
GO:0005515	protein binding	16730713.17301792.18325344.21081126.21278788.22451927.25277244.25416956.	IPI	Function
GO:0005615	extracellular space	15319436.	IDA	Component
GO:0005634	nucleus	11598139.	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	15162379.	IDA	Component
GO:0005737	cytoplasm	16130169.	TAS	Component
GO:0005771	multivesicular body	15319436.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005881	cytoplasmic microtubule	15162379.	IDA	Component
GO:0006816	calcium ion transport	15958728.	IC	Process
GO:0006874	cellular calcium ion homeostasis	15958728.	IC	Process
GO:0009615	response to virus	16548883.	IEP	Process
GO:0042981	regulation of apoptotic process	15162379.	NAS	Process
GO:0043066	negative regulation of apoptotic process	16130169.	TAS	Process
GO:0070062	extracellular exosome	23533145.	HDA	Component
GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	11598139.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.