EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
21724586	Overexpression of MBD2 in glioblastoma maintains epigenetic silencing and inhibits the antiangiogenic function of the tumor suppressor gene BAI1.	Cancer Res	2011 Sep 1	Zhu D	doi: 10.1158/0008-5472.CAN-11-1157
12646234	Methyl-CpG-DNA binding proteins in human prostate cancer: expression of CXXC sequence containing MBD1 and repression of MBD2 and MeCP2.	Biochem Biophys Res Commun	2003 Mar 21	Patra SK	-
14688029	Methylated DNA-binding protein 2 antisense inhibitors suppress tumourigenesis of human cancer cell lines in vitro and in vivo.	Carcinogenesis	2004 Apr	Campbell PM	-
18931530	MBD2-mediated transcriptional repression of the p14ARF tumor suppressor gene in human colon cancer cells.	Pathobiology	2008	Martin V	doi: 10.1159/000151708
21693597	Methyl-binding domain protein 2-dependent proliferation and survival of breast cancer cells.	Mol Cancer Res	2011 Aug	Mian OY	doi: 10.1158/1541-7786.MCR-11-0252
24204564	Methylated DNA binding domain protein 2 (MBD2) coordinately silences gene expression through activation of the microRNA hsa-mir-496 promoter in breast cancer cell line.	PLoS One	2013 Oct 29	Alvarado S	doi: 10.1371/journal.pone.0074009
22258532	A two-stage association study identifies methyl-CpG-binding domain protein 2 gene polymorphisms as candidates for breast cancer susceptibility.	Eur J Hum Genet	2012 Jun	Sapkota Y	doi: 10.1038/ejhg.2011.273
16052033	Specific binding of the methyl binding domain protein 2 at the BRCA1-NBR2 locus.	Nucleic Acids Res	2005 Jul 28	Auriol E	-
24927503	Genome-wide binding of MBD2 reveals strong preference for highly methylated loci.	PLoS One	2014 Jun 13	Menafra R	doi: 10.1371/journal.pone.0099603
18952593	Specific association between the methyl-CpG-binding domain protein 2 and the hypermethylated region of the human telomerase reverse transcriptase promoter in cancer cells.	Carcinogenesis	2009 Jan	Chatagnon A	doi: 10.1093/carcin/bgn240
23770133	Decreased levels of miR-224 and the passenger strand of miR-221 increase MBD2, suppressing maspin and promoting colorectal tumor growth and metastasis in mice.	Gastroenterology	2013 Oct	Yuan K	doi: 10.1053/j.gastro.2013.06.008
16168120	Genotypes and haplotypes of the methyl-CpG-binding domain 2 modify breast cancer risk dependent upon menopausal status.	Breast Cancer Res	2005	Zhu Y	-
27593931	Methyl-CpG-binding protein MBD2 plays a key role in maintenance and spread of DNA methylation at CpG islands and shores in cancer.	Oncogene	2017 Mar	Stirzaker C	doi: 10.1038/onc.2016.297

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr18	54205006	Nonsense_Mutation	novel	Q232*	0.24
BLCA	chr18	54203008	Intron	novel		0.03
BLCA	chr18	54202826	Intron	novel		0.53
BLCA	chr18	54202741	Intron	novel		0.36
BLCA	chr18	54205139	Silent	novel	F187F	0.1
BLCA	chr18	54205043	Silent	NA	Q219Q	0.32
BLCA	chr18	54224079	Missense_Mutation	novel	K161E	0.26	MBD
BRCA	chr18	54155107	3'UTR	novel		0.26
BRCA	chr18	54154825	3'UTR	novel		0.4
BRCA	chr18	54203070	Intron	novel		0.11
BRCA	chr18	54202924	Intron	novel		0.13
CESC	chr18	54155021	3'UTR	rs568556286		0.39
CESC	chr18	54154830	3'UTR	novel		0.4
COAD	chr18	54224030	Missense_Mutation	novel	V177A	0.41	MBD
COAD	chr18	54205043	Silent	NA	Q219Q	0.21
COAD	chr18	54164657	Silent	novel	V325V	0.3
COAD	chr18	54205047	Missense_Mutation	novel	L218S	0.41
COAD	chr18	54205024	Nonsense_Mutation	NA	R226*	0.25
DLBC	chr18	54202991	Intron	novel		0.09
ESCA	chr18	54224089	Frame_Shift_Del	rs755716804	*G158Dfs7**	0.23	MBD
GBM	chr18	54203104	Intron	novel		0.05
GBM	chr18	54166106	Missense_Mutation	novel	K301Q	0.13
GBM	chr18	54203083	Intron	novel		0.05
KIRC	chr18	54205138	Nonsense_Mutation	novel	R188*	0.08	MBD
LGG	chr18	54188883	Missense_Mutation	novel	Q277H	0.06
LGG	chr18	54222414	Intron	novel		0.44
LUAD	chr18	54202861	Intron	novel		0.32
LUAD	chr18	54159846	Silent	NA	A389A	0.85
LUAD	chr18	54205018	Missense_Mutation	rs780970674	D228N	0.35
LUAD	chr18	54205032	Frame_Shift_Del	novel	*Q223Efs11**	0.14
LUAD	chr18	54202944	Intron	novel		0.43
LUAD	chr18	54159785	Missense_Mutation	novel	E410K	0.41
LUAD	chr18	54202789	Intron	novel		0.33
LUSC	chr18	54224150	Missense_Mutation	NA	G137A	0.21
OV	chr18	54164669	Silent	novel	L321L	0.06
OV	chr18	54164670	Missense_Mutation	novel	L321P	0.06
PAAD	chr18	54159874	Missense_Mutation	novel	R380H	0.14
PAAD	chr18	54159890	Nonsense_Mutation	NA	R375*	0.13
PAAD	chr18	54188886	Missense_Mutation	novel	E276D	0.17
PAAD	chr18	54224042	Missense_Mutation	novel	G173D	0.09	MBD
READ	chr18	54203047	Intron	NA		0.22
READ	chr18	54203039	Intron	rs776235444		0.29
READ	chr18	54166118	Nonsense_Mutation	NA	E297*	0.32
SARC	chr18	54155122	3'UTR	novel		0.31
SKCM	chr18	54224103	Missense_Mutation	novel	P153S	0.25	MBD
SKCM	chr18	54202923	Intron	novel		0.35
SKCM	chr18	54203022	Intron	rs747604803		0.22
SKCM	chr18	54202904	Intron	novel		0.39
STAD	chr18	54164631	Missense_Mutation	rs201919549	A334V	0.39
STAD	chr18	54224089	Frame_Shift_Del	rs755716804	*G158Dfs7**	0.29	MBD
STAD	chr18	54224089	Frame_Shift_Del	rs755716804	*G158Dfs7**	0.25	MBD
STAD	chr18	54159875	Missense_Mutation	NA	R380C	0.37
STAD	chr18	54202787	Intron	novel		0.12
STAD	chr18	54205024	Nonsense_Mutation	NA	R226*	0.07
STAD	chr18	54203006	Intron	novel		0.11
STAD	chr18	54224154	Missense_Mutation	NA	P136S	0.16
STAD	chr18	54164608	Missense_Mutation	rs182260595	A342T	0.14
STAD	chr18	54164655	Missense_Mutation	NA	A326V	0.07
THCA	chr18	54203008	Intron	novel		0.03
THYM	chr18	54202987	Intron	novel		0.32
UCEC	chr18	54166118	Nonsense_Mutation	NA	E297*	0.34
UCEC	chr18	54202734	Intron	novel		0.35
UCEC	chr18	54159870	Missense_Mutation	novel	K381N	0.29
UCEC	chr18	54188896	Missense_Mutation	novel	R273Q	0.47
UCEC	chr18	54164551	Missense_Mutation	novel	A361S	0.36
UCEC	chr18	54205116	Missense_Mutation	novel	R195M	0.39	MBD
UCEC	chr18	54188878	Missense_Mutation	NA	R279H	0.34
UCEC	chr18	54166142	Nonsense_Mutation	NA	G289*	0.18
UCEC	chr18	54202957	Intron	novel		0.18
UCEC	chr18	54222344	Intron	novel		0.36
UCEC	chr18	54154855	3'UTR	novel		0.32
UCEC	chr18	54205074	Missense_Mutation	novel	R209I	0.13	MBD
UCEC	chr18	54222318	Intron	novel		0.11
UCEC	chr18	54189012	Splice_Site	novel	X235_splice	0.33
UCEC	chr18	54202817	Intron	novel		0.31
UCEC	chr18	54154857	3'UTR	novel		0.49
UCEC	chr18	54205023	Missense_Mutation	rs745860253	R226Q	0.3
UCEC	chr18	54188896	Missense_Mutation	novel	R273L	0.44
UCEC	chr18	54159874	Missense_Mutation	novel	R380H	0.28
UCEC	chr18	54202965	Intron	novel		0.3
UCEC	chr18	54188933	Missense_Mutation	novel	N261H	0.46
UCEC	chr18	54159812	Missense_Mutation	NA	M401L	0.25
UCEC	chr18	54154855	3'UTR	novel		0.15
UCEC	chr18	54188897	Nonsense_Mutation	NA	R273*	0.19
UCEC	chr18	54164664	Frame_Shift_Ins	novel	*S323Ffs72**	0.07
UCEC	chr18	54159861	Nonsense_Mutation	novel	*E385Gfs3**	0.1
UCEC	chr18	54159870	Missense_Mutation	novel	K381N	0.39
UCEC	chr18	54159823	Missense_Mutation	NA	D397G	0.31
UCEC	chr18	54164599	Missense_Mutation	novel	E345K	0.31
UCEC	chr18	54202877	Intron	novel		0.29

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	AMP	0.3333	0.065049
LIHC	DEL	0.2297	0.019373
LUAD	DEL	0.3915	1.1082e-09
UCEC	DEL	0.1429	0.006131
UCS	DEL	0.3929	0.12533

Survival Analysis

Cancer	P-value	Q-value
THYM	0.011	Kaplan-Meier Survival Analysis
KIRC	0.0019	Kaplan-Meier Survival Analysis
ACC	0.0011	Kaplan-Meier Survival Analysis
SKCM	0.00011	Kaplan-Meier Survival Analysis
PRAD	0.02	Kaplan-Meier Survival Analysis
LUSC	0.0069	Kaplan-Meier Survival Analysis
BRCA	0.047	Kaplan-Meier Survival Analysis
KIRP	0.0058	Kaplan-Meier Survival Analysis
COAD	0.031	Kaplan-Meier Survival Analysis
PAAD	0.029	Kaplan-Meier Survival Analysis
BLCA	0.048	Kaplan-Meier Survival Analysis
LAML	0.028	Kaplan-Meier Survival Analysis
GBM	0.026	Kaplan-Meier Survival Analysis
LIHC	0.0059	Kaplan-Meier Survival Analysis
LGG	0.00013	Kaplan-Meier Survival Analysis
LUAD	0.023	Kaplan-Meier Survival Analysis
UVM	0.0019	Kaplan-Meier Survival Analysis
OV	0.0067	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000134046 (Gene tree)
Gene ID: 8932
Gene Symbol: MBD2
Alias: -
Full Name: methyl-CpG binding domain protein 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 73,188 bases
Position: chr18:54,151,601-54,224,788
Accession: 6917
RBP type: canonical RBP
Summary: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000256429	MBD	PF01429.19	4.7e-27	1	1
ENSP00000381435	MBD	PF01429.19	1.1e-22	1	1
ENSP00000464554	MBD	PF01429.19	1.5e-22	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
23955541	Transcription onset of genes critical in liver carcinogenesis is epigenetically regulated by methylated DNA-binding protein MBD2.	Carcinogenesis	2013 Dec	Stefanska B	doi: 10.1093/carcin/bgt273
24923522	Epigenetic modification of the leptin promoter in diet-induced obese mice and the effects of N-3 polyunsaturated fatty acids.	Sci Rep	2014 Jun 13	Shen W	doi: 10.1038/srep05282.
16052033	Specific binding of the methyl binding domain protein 2 at the BRCA1-NBR2 locus.	Nucleic Acids Res	2005 Jul 28	Auriol E	-
14610093	Role of human ribosomal RNA (rRNA) promoter methylation and of methyl-CpG-binding protein MBD2 in the suppression of rRNA gene expression.	J Biol Chem	2004 Feb 20	Ghoshal K	-
24067901	Dietary black raspberries modulate DNA methylation in dextran sodium sulfate (DSS)-induced ulcerative colitis.	Carcinogenesis	2013 Dec	Wang LS	doi: 10.1093/carcin/bgt310
23979593	Mbd2 promotes foxp3 demethylation and T-regulatory-cell function.	Mol Cell Biol	2013 Oct	Wang L	doi: 10.1128/MCB.00144-13

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000256429	MBD2-201	5188	-	ENSP00000256429	411 (aa)	-	Q9UBB5
ENST00000578272	MBD2-203	701	-	ENSP00000462393	72 (aa)	-	J3KSA7
ENST00000398398	MBD2-202	1237	-	ENSP00000381435	241 (aa)	-	X6RBL6
ENST00000583046	MBD2-205	1182	-	ENSP00000464554	302 (aa)	-	Q9UBB5
ENST00000579025	MBD2-204	241	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000134046's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000134046	rs572797	18	54180445	?	Mean corpuscular hemoglobin	30595370			EFO_0004527
ENSG00000134046	rs12957175	18	54217681	?	White blood cell count	30595370			EFO_0004308

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000134046's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000134046	MBD2	83	75.000	ENSAPOG00000012600	mbd2	93	81.614	Acanthochromis_polyacanthus
ENSG00000134046	MBD2	78	76.786	ENSAPOG00000005056	-	91	80.400	Acanthochromis_polyacanthus
ENSG00000134046	MBD2	83	93.333	ENSAMEG00000017208	MBD2	100	99.303	Ailuropoda_melanoleuca
ENSG00000134046	MBD2	83	72.131	ENSACIG00000012586	mbd2	90	79.079	Amphilophus_citrinellus
ENSG00000134046	MBD2	78	76.786	ENSACIG00000014984	-	91	80.400	Amphilophus_citrinellus
ENSG00000134046	MBD2	83	73.333	ENSAOCG00000003632	-	95	79.200	Amphiprion_ocellaris
ENSG00000134046	MBD2	78	76.786	ENSAOCG00000009832	-	91	80.400	Amphiprion_ocellaris
ENSG00000134046	MBD2	83	73.333	ENSAPEG00000021428	-	95	79.200	Amphiprion_percula
ENSG00000134046	MBD2	78	76.786	ENSAPEG00000007136	-	91	80.400	Amphiprion_percula
ENSG00000134046	MBD2	72	78.846	ENSATEG00000007353	-	94	78.486	Anabas_testudineus
ENSG00000134046	MBD2	78	76.786	ENSATEG00000024182	-	91	80.400	Anabas_testudineus
ENSG00000134046	MBD2	82	74.576	ENSAPLG00000003384	-	83	77.000	Anas_platyrhynchos
ENSG00000134046	MBD2	83	86.667	ENSAPLG00000010058	MBD2	100	91.489	Anas_platyrhynchos
ENSG00000134046	MBD2	83	86.667	ENSACAG00000008739	MBD2	99	93.233	Anolis_carolinensis
ENSG00000134046	MBD2	82	74.576	ENSANAG00000026084	MBD3	86	76.000	Aotus_nancymaae
ENSG00000134046	MBD2	83	93.333	ENSANAG00000030070	MBD2	100	88.406	Aotus_nancymaae
ENSG00000134046	MBD2	83	72.131	ENSACLG00000004512	mbd2	94	79.681	Astatotilapia_calliptera
ENSG00000134046	MBD2	78	75.000	ENSACLG00000023390	-	91	80.000	Astatotilapia_calliptera
ENSG00000134046	MBD2	76	76.364	ENSAMXG00000041394	mbd3a	97	74.060	Astyanax_mexicanus
ENSG00000134046	MBD2	79	75.439	ENSAMXG00000042143	-	97	78.210	Astyanax_mexicanus
ENSG00000134046	MBD2	83	93.333	ENSBTAG00000037457	MBD2	100	88.010	Bos_taurus
ENSG00000134046	MBD2	82	74.576	ENSCJAG00000043037	MBD3	98	74.348	Callithrix_jacchus
ENSG00000134046	MBD2	100	100.000	ENSCJAG00000040234	MBD2	100	98.792	Callithrix_jacchus
ENSG00000134046	MBD2	100	100.000	ENSCAFG00020021622	MBD2	100	98.118	Canis_lupus_dingo
ENSG00000134046	MBD2	99	95.884	ENSCHIG00000011602	MBD2	99	95.884	Capra_hircus
ENSG00000134046	MBD2	82	74.576	ENSCHIG00000024579	MBD3	87	76.000	Capra_hircus
ENSG00000134046	MBD2	83	93.333	ENSTSYG00000013361	MBD2	62	98.696	Carlito_syrichta
ENSG00000134046	MBD2	83	91.667	ENSCAPG00000014843	MBD2	100	99.565	Cavia_aperea
ENSG00000134046	MBD2	83	91.667	ENSCPOG00000006832	MBD2	86	99.650	Cavia_porcellus
ENSG00000134046	MBD2	82	74.576	ENSCPOG00000026210	MBD3	86	76.000	Cavia_porcellus
ENSG00000134046	MBD2	100	98.558	ENSCCAG00000037922	MBD2	100	98.558	Cebus_capucinus
ENSG00000134046	MBD2	82	74.576	ENSCCAG00000026526	MBD3	79	78.140	Cebus_capucinus
ENSG00000134046	MBD2	82	74.576	ENSCATG00000044174	MBD3	85	76.613	Cercocebus_atys
ENSG00000134046	MBD2	100	95.377	ENSCATG00000040536	MBD2	100	95.377	Cercocebus_atys
ENSG00000134046	MBD2	87	97.561	ENSCLAG00000010471	MBD2	100	95.745	Chinchilla_lanigera
ENSG00000134046	MBD2	83	93.333	ENSCSAG00000018106	MBD2	100	100.000	Chlorocebus_sabaeus
ENSG00000134046	MBD2	82	74.576	ENSCSAG00000011976	MBD3	86	76.000	Chlorocebus_sabaeus
ENSG00000134046	MBD2	56	75.652	ENSCHOG00000012250	-	100	75.652	Choloepus_hoffmanni
ENSG00000134046	MBD2	83	86.667	ENSCPBG00000025606	MBD2	98	94.318	Chrysemys_picta_bellii
ENSG00000134046	MBD2	82	74.576	ENSCPBG00000018443	-	93	75.564	Chrysemys_picta_bellii
ENSG00000134046	MBD2	83	93.333	ENSCANG00000032494	MBD2	100	100.000	Colobus_angolensis_palliatus
ENSG00000134046	MBD2	100	97.087	ENSCGRG00001017384	Mbd2	100	97.087	Cricetulus_griseus_chok1gshd
ENSG00000134046	MBD2	82	74.576	ENSCGRG00001024592	Mbd3	88	75.200	Cricetulus_griseus_chok1gshd
ENSG00000134046	MBD2	83	91.667	ENSCGRG00000015077	Mbd2	72	97.835	Cricetulus_griseus_crigri
ENSG00000134046	MBD2	78	78.571	ENSCSEG00000005775	-	91	81.200	Cynoglossus_semilaevis
ENSG00000134046	MBD2	83	70.492	ENSCSEG00000017016	-	96	77.419	Cynoglossus_semilaevis
ENSG00000134046	MBD2	83	70.492	ENSCVAG00000011821	mbd2	96	74.510	Cyprinodon_variegatus
ENSG00000134046	MBD2	78	76.786	ENSCVAG00000005691	-	91	80.800	Cyprinodon_variegatus
ENSG00000134046	MBD2	78	78.571	ENSDARG00000061774	mbd3a	97	74.812	Danio_rerio
ENSG00000134046	MBD2	76	83.636	ENSDARG00000075952	mbd2	98	85.821	Danio_rerio
ENSG00000134046	MBD2	82	71.186	ENSDNOG00000031786	MBD3	63	69.231	Dasypus_novemcinctus
ENSG00000134046	MBD2	100	97.080	ENSDNOG00000033421	MBD2	100	97.080	Dasypus_novemcinctus
ENSG00000134046	MBD2	83	91.667	ENSDORG00000029792	Mbd2	80	92.177	Dipodomys_ordii
ENSG00000134046	MBD2	71	46.296	FBgn0027950	MBD-like	98	37.945	Drosophila_melanogaster
ENSG00000134046	MBD2	83	93.333	ENSETEG00000020139	-	56	97.403	Echinops_telfairi
ENSG00000134046	MBD2	78	66.071	ENSEBUG00000011092	mbd3a	97	63.035	Eptatretus_burgeri
ENSG00000134046	MBD2	83	70.000	ENSEBUG00000005327	MBD2	94	76.378	Eptatretus_burgeri
ENSG00000134046	MBD2	82	74.576	ENSEASG00005021748	MBD3	86	75.600	Equus_asinus_asinus
ENSG00000134046	MBD2	100	98.783	ENSEASG00005003504	MBD2	100	98.783	Equus_asinus_asinus
ENSG00000134046	MBD2	100	98.783	ENSECAG00000022368	MBD2	100	98.783	Equus_caballus
ENSG00000134046	MBD2	72	90.385	ENSEEUG00000000166	-	63	77.907	Erinaceus_europaeus
ENSG00000134046	MBD2	78	76.786	ENSELUG00000018490	-	92	79.200	Esox_lucius
ENSG00000134046	MBD2	82	74.576	ENSFCAG00000000763	MBD3	85	75.806	Felis_catus
ENSG00000134046	MBD2	100	99.270	ENSFCAG00000022047	MBD2	100	99.270	Felis_catus
ENSG00000134046	MBD2	83	93.333	ENSFDAG00000015096	MBD2	100	99.565	Fukomys_damarensis
ENSG00000134046	MBD2	72	76.923	ENSFHEG00000014371	mbd2	95	77.291	Fundulus_heteroclitus
ENSG00000134046	MBD2	78	76.786	ENSFHEG00000012553	-	91	80.000	Fundulus_heteroclitus
ENSG00000134046	MBD2	78	76.786	ENSGMOG00000008953	-	91	78.319	Gadus_morhua
ENSG00000134046	MBD2	72	73.077	ENSGMOG00000000288	-	100	52.245	Gadus_morhua
ENSG00000134046	MBD2	72	78.846	ENSGAFG00000007177	mbd2	95	77.689	Gambusia_affinis
ENSG00000134046	MBD2	78	76.786	ENSGAFG00000002334	-	88	80.374	Gambusia_affinis
ENSG00000134046	MBD2	72	80.769	ENSGACG00000018294	mbd2	97	75.581	Gasterosteus_aculeatus
ENSG00000134046	MBD2	78	80.357	ENSGACG00000012755	-	96	76.395	Gasterosteus_aculeatus
ENSG00000134046	MBD2	82	74.576	ENSGAGG00000001227	-	93	75.564	Gopherus_agassizii
ENSG00000134046	MBD2	100	99.757	ENSGGOG00000013402	MBD2	100	99.757	Gorilla_gorilla
ENSG00000134046	MBD2	83	72.131	ENSHBUG00000014830	-	94	80.080	Haplochromis_burtoni
ENSG00000134046	MBD2	78	75.000	ENSHBUG00000006135	-	91	80.000	Haplochromis_burtoni
ENSG00000134046	MBD2	100	96.107	ENSHGLG00000006906	MBD2	100	96.107	Heterocephalus_glaber_female
ENSG00000134046	MBD2	82	74.576	ENSHGLG00000018023	MBD3	91	73.208	Heterocephalus_glaber_female
ENSG00000134046	MBD2	83	93.333	ENSHGLG00100009927	MBD2	94	99.565	Heterocephalus_glaber_male
ENSG00000134046	MBD2	78	78.571	ENSHCOG00000001410	-	96	78.409	Hippocampus_comes
ENSG00000134046	MBD2	72	80.769	ENSHCOG00000016363	-	89	77.350	Hippocampus_comes
ENSG00000134046	MBD2	78	75.000	ENSIPUG00000024191	-	89	66.055	Ictalurus_punctatus
ENSG00000134046	MBD2	83	73.333	ENSIPUG00000018813	mbd2	95	80.478	Ictalurus_punctatus
ENSG00000134046	MBD2	78	75.000	ENSIPUG00000019419	MBD3	97	73.408	Ictalurus_punctatus
ENSG00000134046	MBD2	83	93.333	ENSSTOG00000011253	MBD2	100	99.643	Ictidomys_tridecemlineatus
ENSG00000134046	MBD2	82	74.576	ENSSTOG00000015870	MBD3	86	76.735	Ictidomys_tridecemlineatus
ENSG00000134046	MBD2	82	74.576	ENSJJAG00000013343	Mbd3	96	70.504	Jaculus_jaculus
ENSG00000134046	MBD2	83	91.667	ENSJJAG00000024363	Mbd2	79	98.252	Jaculus_jaculus
ENSG00000134046	MBD2	78	76.786	ENSKMAG00000003388	-	91	80.400	Kryptolebias_marmoratus
ENSG00000134046	MBD2	83	75.410	ENSKMAG00000006501	mbd2	94	78.486	Kryptolebias_marmoratus
ENSG00000134046	MBD2	78	76.786	ENSLBEG00000018071	-	91	80.400	Labrus_bergylta
ENSG00000134046	MBD2	74	73.585	ENSLBEG00000021918	mbd2	91	69.615	Labrus_bergylta
ENSG00000134046	MBD2	82	72.881	ENSLACG00000016498	mbd3a	91	79.283	Latimeria_chalumnae
ENSG00000134046	MBD2	83	90.000	ENSLACG00000016038	MBD2	99	91.635	Latimeria_chalumnae
ENSG00000134046	MBD2	83	81.667	ENSLOCG00000003370	MBD2	97	86.434	Lepisosteus_oculatus
ENSG00000134046	MBD2	82	72.881	ENSLOCG00000006043	MBD3	72	76.316	Lepisosteus_oculatus
ENSG00000134046	MBD2	82	72.881	ENSLAFG00000005756	MBD3	88	75.417	Loxodonta_africana
ENSG00000134046	MBD2	83	93.333	ENSLAFG00000014135	MBD2	100	99.322	Loxodonta_africana
ENSG00000134046	MBD2	82	74.576	ENSMFAG00000044264	MBD3	85	76.613	Macaca_fascicularis
ENSG00000134046	MBD2	100	88.564	ENSMFAG00000030736	MBD2	100	89.781	Macaca_fascicularis
ENSG00000134046	MBD2	100	99.174	ENSMMUG00000003136	MBD2	100	100.000	Macaca_mulatta
ENSG00000134046	MBD2	100	89.320	ENSMNEG00000028536	MBD2	100	78.008	Macaca_nemestrina
ENSG00000134046	MBD2	83	93.333	ENSMLEG00000028274	MBD2	96	99.283	Mandrillus_leucophaeus
ENSG00000134046	MBD2	83	73.770	ENSMAMG00000018791	mbd2	95	80.080	Mastacembelus_armatus
ENSG00000134046	MBD2	78	76.786	ENSMAMG00000019593	-	91	80.400	Mastacembelus_armatus
ENSG00000134046	MBD2	83	72.131	ENSMZEG00005001327	mbd2	94	79.681	Maylandia_zebra
ENSG00000134046	MBD2	78	75.000	ENSMZEG00005006883	-	91	80.000	Maylandia_zebra
ENSG00000134046	MBD2	76	83.636	ENSMGAG00000009222	-	100	88.235	Meleagris_gallopavo
ENSG00000134046	MBD2	100	87.621	ENSMAUG00000013342	Mbd2	71	97.938	Mesocricetus_auratus
ENSG00000134046	MBD2	82	74.576	ENSMAUG00000020118	Mbd3	97	71.014	Mesocricetus_auratus
ENSG00000134046	MBD2	83	93.333	ENSMICG00000008970	MBD2	97	78.205	Microcebus_murinus
ENSG00000134046	MBD2	82	74.576	ENSMICG00000000808	MBD3	86	76.000	Microcebus_murinus
ENSG00000134046	MBD2	82	74.576	ENSMOCG00000021527	Mbd3	87	75.403	Microtus_ochrogaster
ENSG00000134046	MBD2	86	100.000	ENSMOCG00000016997	Mbd2	97	100.000	Microtus_ochrogaster
ENSG00000134046	MBD2	78	76.786	ENSMMOG00000000372	-	91	80.400	Mola_mola
ENSG00000134046	MBD2	83	75.410	ENSMMOG00000011781	-	97	76.744	Mola_mola
ENSG00000134046	MBD2	82	74.576	ENSMODG00000004125	-	78	79.070	Monodelphis_domestica
ENSG00000134046	MBD2	100	91.827	ENSMODG00000011041	MBD2	100	91.106	Monodelphis_domestica
ENSG00000134046	MBD2	83	70.492	ENSMALG00000001538	mbd2	94	78.088	Monopterus_albus
ENSG00000134046	MBD2	78	76.786	ENSMALG00000007914	MBD3	91	80.400	Monopterus_albus
ENSG00000134046	MBD2	100	95.642	MGP_CAROLIEiJ_G0022389	Mbd2	100	93.462	Mus_caroli
ENSG00000134046	MBD2	82	74.576	MGP_CAROLIEiJ_G0015583	Mbd3	88	75.200	Mus_caroli
ENSG00000134046	MBD2	82	74.576	ENSMUSG00000035478	Mbd3	88	75.200	Mus_musculus
ENSG00000134046	MBD2	100	96.627	ENSMUSG00000024513	Mbd2	100	96.627	Mus_musculus
ENSG00000134046	MBD2	100	96.377	MGP_PahariEiJ_G0019117	Mbd2	100	96.377	Mus_pahari
ENSG00000134046	MBD2	82	74.576	MGP_PahariEiJ_G0030996	Mbd3	88	75.200	Mus_pahari
ENSG00000134046	MBD2	82	74.576	MGP_SPRETEiJ_G0016401	Mbd3	88	75.200	Mus_spretus
ENSG00000134046	MBD2	100	96.845	MGP_SPRETEiJ_G0023301	Mbd2	100	98.473	Mus_spretus
ENSG00000134046	MBD2	100	79.612	ENSMLUG00000009980	MBD2	71	85.172	Myotis_lucifugus
ENSG00000134046	MBD2	82	76.271	ENSNGAG00000022652	Mbd3	87	75.403	Nannospalax_galili
ENSG00000134046	MBD2	79	97.692	ENSNGAG00000018354	Mbd2	100	100.000	Nannospalax_galili
ENSG00000134046	MBD2	78	75.000	ENSNBRG00000011072	-	91	80.000	Neolamprologus_brichardi
ENSG00000134046	MBD2	83	72.131	ENSNBRG00000003778	mbd2	95	80.080	Neolamprologus_brichardi
ENSG00000134046	MBD2	82	77.966	ENSNLEG00000001734	MBD3	93	66.418	Nomascus_leucogenys
ENSG00000134046	MBD2	83	93.333	ENSNLEG00000031955	-	100	100.000	Nomascus_leucogenys
ENSG00000134046	MBD2	83	93.333	ENSMEUG00000016480	MBD2	93	97.826	Notamacropus_eugenii
ENSG00000134046	MBD2	74	79.245	ENSMEUG00000003078	-	87	69.200	Notamacropus_eugenii
ENSG00000134046	MBD2	82	74.576	ENSODEG00000012920	MBD3	91	73.208	Octodon_degus
ENSG00000134046	MBD2	79	99.310	ENSODEG00000018422	MBD2	97	99.313	Octodon_degus
ENSG00000134046	MBD2	83	72.131	ENSONIG00000012635	mbd2	94	80.080	Oreochromis_niloticus
ENSG00000134046	MBD2	100	97.222	ENSOANG00000030623	-	87	92.727	Ornithorhynchus_anatinus
ENSG00000134046	MBD2	83	93.333	ENSOCUG00000021080	MBD2	99	97.324	Oryctolagus_cuniculus
ENSG00000134046	MBD2	78	78.571	ENSORLG00000004850	-	91	77.821	Oryzias_latipes
ENSG00000134046	MBD2	72	78.846	ENSORLG00000024771	mbd2	87	81.250	Oryzias_latipes
ENSG00000134046	MBD2	78	78.571	ENSORLG00020003297	-	91	80.400	Oryzias_latipes_hni
ENSG00000134046	MBD2	78	78.571	ENSORLG00015021178	-	91	80.400	Oryzias_latipes_hsok
ENSG00000134046	MBD2	72	78.846	ENSORLG00015014273	mbd2	96	79.283	Oryzias_latipes_hsok
ENSG00000134046	MBD2	72	78.846	ENSOMEG00000004312	mbd2	96	78.884	Oryzias_melastigma
ENSG00000134046	MBD2	78	78.571	ENSOMEG00000005272	-	91	80.400	Oryzias_melastigma
ENSG00000134046	MBD2	83	90.000	ENSOGAG00000008028	MBD2	100	97.306	Otolemur_garnettii
ENSG00000134046	MBD2	82	74.576	ENSOGAG00000024563	MBD3	89	69.231	Otolemur_garnettii
ENSG00000134046	MBD2	83	93.333	ENSOARG00000004770	MBD2	100	93.117	Ovis_aries
ENSG00000134046	MBD2	83	93.333	ENSPPAG00000030303	-	88	100.000	Pan_paniscus
ENSG00000134046	MBD2	82	74.576	ENSPPAG00000031282	MBD3	79	78.140	Pan_paniscus
ENSG00000134046	MBD2	100	99.270	ENSPPRG00000001698	MBD2	100	99.270	Panthera_pardus
ENSG00000134046	MBD2	82	74.576	ENSPPRG00000023894	MBD3	85	75.806	Panthera_pardus
ENSG00000134046	MBD2	83	93.333	ENSPTIG00000011491	MBD2	70	99.301	Panthera_tigris_altaica
ENSG00000134046	MBD2	100	84.185	ENSPTRG00000010033	MBD2	76	98.625	Pan_troglodytes
ENSG00000134046	MBD2	82	74.576	ENSPTRG00000010209	MBD3	86	76.000	Pan_troglodytes
ENSG00000134046	MBD2	82	74.576	ENSPANG00000015324	MBD3	85	76.613	Papio_anubis
ENSG00000134046	MBD2	100	99.272	ENSPANG00000021858	MBD2	100	99.272	Papio_anubis
ENSG00000134046	MBD2	78	76.786	ENSPKIG00000018562	mbd3a	91	80.242	Paramormyrops_kingsleyae
ENSG00000134046	MBD2	83	78.333	ENSPKIG00000015756	mbd2	98	81.712	Paramormyrops_kingsleyae
ENSG00000134046	MBD2	75	77.778	ENSPMGG00000012079	-	96	70.916	Periophthalmus_magnuspinnatus
ENSG00000134046	MBD2	78	75.000	ENSPMGG00000014713	-	91	79.600	Periophthalmus_magnuspinnatus
ENSG00000134046	MBD2	83	91.667	ENSPEMG00000020730	Mbd2	85	98.282	Peromyscus_maniculatus_bairdii
ENSG00000134046	MBD2	83	71.667	ENSPMAG00000000415	mbd3a	94	69.091	Petromyzon_marinus
ENSG00000134046	MBD2	97	86.498	ENSPCIG00000003608	MBD2	100	90.580	Phascolarctos_cinereus
ENSG00000134046	MBD2	82	74.576	ENSPCIG00000000783	-	87	78.400	Phascolarctos_cinereus
ENSG00000134046	MBD2	72	78.846	ENSPFOG00000003939	mbd2	95	78.486	Poecilia_formosa
ENSG00000134046	MBD2	78	76.786	ENSPFOG00000001910	-	88	80.374	Poecilia_formosa
ENSG00000134046	MBD2	72	78.846	ENSPLAG00000020914	mbd2	95	78.088	Poecilia_latipinna
ENSG00000134046	MBD2	78	76.786	ENSPLAG00000009897	-	91	80.400	Poecilia_latipinna
ENSG00000134046	MBD2	78	76.786	ENSPMEG00000004758	-	91	80.400	Poecilia_mexicana
ENSG00000134046	MBD2	78	76.786	ENSPREG00000008542	-	91	80.400	Poecilia_reticulata
ENSG00000134046	MBD2	72	78.846	ENSPREG00000013458	mbd2	95	78.486	Poecilia_reticulata
ENSG00000134046	MBD2	72	92.308	ENSPPYG00000009168	-	100	78.244	Pongo_abelii
ENSG00000134046	MBD2	100	98.783	ENSPCOG00000013359	MBD2	100	98.783	Propithecus_coquereli
ENSG00000134046	MBD2	82	76.271	ENSPVAG00000017085	MBD3	86	76.613	Pteropus_vampyrus
ENSG00000134046	MBD2	97	91.453	ENSPVAG00000008555	MBD2	81	99.000	Pteropus_vampyrus
ENSG00000134046	MBD2	78	75.000	ENSPNYG00000017202	-	91	80.000	Pundamilia_nyererei
ENSG00000134046	MBD2	83	72.131	ENSPNYG00000003862	mbd2	86	82.143	Pundamilia_nyererei
ENSG00000134046	MBD2	78	75.000	ENSPNAG00000017398	-	90	79.757	Pygocentrus_nattereri
ENSG00000134046	MBD2	79	75.439	ENSPNAG00000009910	mbd2	95	79.681	Pygocentrus_nattereri
ENSG00000134046	MBD2	82	71.186	ENSPNAG00000027268	mbd3a	91	77.419	Pygocentrus_nattereri
ENSG00000134046	MBD2	83	91.667	ENSRNOG00000011853	Mbd2	70	97.241	Rattus_norvegicus
ENSG00000134046	MBD2	85	100.000	ENSRBIG00000042099	MBD2	91	100.000	Rhinopithecus_bieti
ENSG00000134046	MBD2	83	93.333	ENSRROG00000034292	MBD2	85	100.000	Rhinopithecus_roxellana
ENSG00000134046	MBD2	82	74.576	ENSSBOG00000031286	MBD3	79	78.140	Saimiri_boliviensis_boliviensis
ENSG00000134046	MBD2	83	93.333	ENSSBOG00000011611	MBD2	78	99.288	Saimiri_boliviensis_boliviensis
ENSG00000134046	MBD2	82	74.576	ENSSHAG00000013346	-	86	77.376	Sarcophilus_harrisii
ENSG00000134046	MBD2	83	73.333	ENSSFOG00015020812	mbd2	96	81.008	Scleropages_formosus
ENSG00000134046	MBD2	78	76.786	ENSSFOG00015003758	mbd3	90	78.899	Scleropages_formosus
ENSG00000134046	MBD2	78	76.786	ENSSMAG00000011344	-	91	80.400	Scophthalmus_maximus
ENSG00000134046	MBD2	72	78.846	ENSSMAG00000011764	mbd2	94	75.697	Scophthalmus_maximus
ENSG00000134046	MBD2	78	76.786	ENSSDUG00000005274	-	91	80.400	Seriola_dumerili
ENSG00000134046	MBD2	83	73.770	ENSSDUG00000017686	mbd2	94	80.080	Seriola_dumerili
ENSG00000134046	MBD2	83	73.770	ENSSLDG00000016580	mbd2	97	78.682	Seriola_lalandi_dorsalis
ENSG00000134046	MBD2	78	76.786	ENSSLDG00000018975	-	91	80.400	Seriola_lalandi_dorsalis
ENSG00000134046	MBD2	83	85.000	ENSSPUG00000017567	-	85	89.372	Sphenodon_punctatus
ENSG00000134046	MBD2	78	76.786	ENSSPAG00000015752	-	91	80.400	Stegastes_partitus
ENSG00000134046	MBD2	83	75.410	ENSSPAG00000013731	-	95	80.876	Stegastes_partitus
ENSG00000134046	MBD2	82	74.576	ENSSSCG00000013435	MBD3	85	76.613	Sus_scrofa
ENSG00000134046	MBD2	99	99.017	ENSSSCG00000004528	MBD2	100	99.017	Sus_scrofa
ENSG00000134046	MBD2	82	72.881	ENSTGUG00000000202	-	97	75.510	Taeniopygia_guttata
ENSG00000134046	MBD2	78	78.571	ENSTRUG00000019805	-	91	80.800	Takifugu_rubripes
ENSG00000134046	MBD2	83	70.492	ENSTRUG00000006522	mbd2	97	72.868	Takifugu_rubripes
ENSG00000134046	MBD2	78	80.357	ENSTNIG00000010627	-	91	81.200	Tetraodon_nigroviridis
ENSG00000134046	MBD2	83	72.131	ENSTNIG00000003709	-	97	74.419	Tetraodon_nigroviridis
ENSG00000134046	MBD2	83	93.333	ENSTBEG00000015292	MBD2	96	95.876	Tupaia_belangeri
ENSG00000134046	MBD2	71	83.276	ENSTTRG00000009635	MBD2	71	83.276	Tursiops_truncatus
ENSG00000134046	MBD2	82	74.576	ENSTTRG00000004412	MBD3	87	75.200	Tursiops_truncatus
ENSG00000134046	MBD2	87	100.000	ENSUAMG00000018438	MBD2	100	100.000	Ursus_americanus
ENSG00000134046	MBD2	83	93.333	ENSUMAG00000003257	MBD2	98	99.138	Ursus_maritimus
ENSG00000134046	MBD2	75	98.148	ENSVPAG00000012298	-	100	89.130	Vicugna_pacos
ENSG00000134046	MBD2	83	91.667	ENSVVUG00000014700	MBD2	100	98.855	Vulpes_vulpes
ENSG00000134046	MBD2	82	76.271	ENSVVUG00000022947	MBD3	80	75.109	Vulpes_vulpes
ENSG00000134046	MBD2	83	88.333	ENSXETG00000013688	mbd2	98	87.786	Xenopus_tropicalis
ENSG00000134046	MBD2	82	76.271	ENSXETG00000013593	mbd3	96	70.833	Xenopus_tropicalis
ENSG00000134046	MBD2	72	78.846	ENSXCOG00000007101	mbd2	95	76.892	Xiphophorus_couchianus
ENSG00000134046	MBD2	72	78.846	ENSXMAG00000003932	mbd2	95	77.291	Xiphophorus_maculatus
ENSG00000134046	MBD2	78	76.786	ENSXMAG00000012716	-	91	80.400	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000118	histone deacetylase complex	-	IEA	Component
GO:0000122	negative regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0000183	chromatin silencing at rDNA	-	TAS	Process
GO:0000790	nuclear chromatin	16217013.	HDA	Component
GO:0000790	nuclear chromatin	23770133.	IDA	Component
GO:0000792	heterochromatin	-	IEA	Component
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	16217013.	HDA	Function
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	16217013.	HDA	Function
GO:0003696	satellite DNA binding	9774669.	TAS	Function
GO:0003729	mRNA binding	-	IEA	Function
GO:0005515	protein binding	12183469.16415179.25753662.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	11553631.	IDA	Component
GO:0005634	nucleus	10441743.	NAS	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006346	methylation-dependent chromatin silencing	21873635.	IBA	Process
GO:0006346	methylation-dependent chromatin silencing	23770133.	IGI	Process
GO:0007507	heart development	-	IEA	Process
GO:0007568	aging	-	IEA	Process
GO:0008327	methyl-CpG binding	21873635.	IBA	Function
GO:0008327	methyl-CpG binding	21029866.24307175.	IDA	Function
GO:0008327	methyl-CpG binding	10441743.	NAS	Function
GO:0009612	response to mechanical stimulus	-	IEA	Process
GO:0019904	protein domain specific binding	11984006.	IPI	Function
GO:0030177	positive regulation of Wnt signaling pathway	-	IEA	Process
GO:0031492	nucleosomal DNA binding	16217013.	HDA	Function
GO:0031667	response to nutrient levels	-	IEA	Process
GO:0032355	response to estradiol	-	IEA	Process
GO:0032991	protein-containing complex	16217013.	HDA	Component
GO:0034622	cellular protein-containing complex assembly	-	IEA	Process
GO:0035197	siRNA binding	-	IEA	Function
GO:0035563	positive regulation of chromatin binding	-	IEA	Process
GO:0042127	regulation of cell proliferation	-	IEA	Process
GO:0042711	maternal behavior	-	IEA	Process
GO:0043044	ATP-dependent chromatin remodeling	16217013.	HDA	Process
GO:0044030	regulation of DNA methylation	-	IEA	Process
GO:0045892	negative regulation of transcription, DNA-templated	10441743.	NAS	Process
GO:0048568	embryonic organ development	-	IEA	Process
GO:0070742	C2H2 zinc finger domain binding	11553631.	IPI	Function
GO:0071407	cellular response to organic cyclic compound	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.