EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26626121	Immunohistochemical evaluation of ROCK activation in invasive breast cancer.	BMC Cancer	2015 Dec 1	Hsu CY	doi: 10.1186/s12885-015-1948-8.
23615712	MiR-126 suppresses colon cancer cell proliferation and invasion via inhibiting RhoA/ROCK signaling pathway.	Mol Cell Biochem	2013 Aug	Li N	doi: 10.1007/s11010-013-1664-0
28031255	ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth.	EMBO Mol Med	2017 Feb	Rath N	doi: 10.15252/emmm.201606743.
18922892	Phosphorylated caveolin-1 regulates Rho/ROCK-dependent focal adhesion dynamics and tumor cell migration and invasion.	Cancer Res	2008 Oct 15	Joshi B	doi: 10.1158/0008-5472.CAN-08-0343.
27628667	Expression of Wnt11 and Rock2 in esophageal squamous cell carcinoma by activation of the WNT/PCP pathway and its clinical significance.	Pathol Res Pract	2016 Oct	Wang X	doi: 10.1016/j.prp.2016.07.008
17344417	Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases.	Genes Dev	2007 Mar 1	Lefort K	-
25755711	Overexpression of ROCK1 and ROCK2 inhibits human laryngeal squamous cell carcinoma.	Int J Clin Exp Pathol	2015 Jan 1	Zhang J	-
22232555	Interplay between β1-integrin and Rho signaling regulates differential scattering and motility of pancreatic cancer cells by snail and Slug proteins.	J Biol Chem	2012 Feb 24	Shields MA	doi: 10.1074/jbc.M111.308940
27921230	Upregulation of ROCK2 in gastric cancer cell promotes tumor cell proliferation, metastasis and invasion.	Clin Exp Med	2017 Nov	Li M	doi: 10.1007/s10238-016-0444-z
30266988	The interaction of Lin28A/Rho associated coiled-coil containing protein kinase2 accelerates the malignancy of ovarian cancer.	Oncogene	2019 Feb	Zhong Y	doi: 10.1038/s41388-018-0512-9
20939434	Association between the Thr431Asn polymorphism of the ROCK2 gene and risk of developing metastases of breast cancer.	Oncol Res	2010	Kalender ME	-
25677806	RhoC and ROCKs regulate cancer cell interactions with endothelial cells.	Mol Oncol	2015 Jun	Reymond N	doi: 10.1016/j.molonc.2015.01.004
20504226	Autocrine motility factor receptor signaling pathway promotes cell invasion via activation of ROCK-2 in esophageal squamous cell cancer cells.	Cancer Invest	2010 Dec	Wang L	doi: 10.3109/07357907.2010.483503
23328676	Role of rho-kinase gene polymorphisms and protein expressions in colorectal cancer development.	Pathobiology	2013	Sari I	doi: 10.1159/000341395
20429915	Vascular endothelial growth factor C promotes cervical cancer metastasis via up-regulation and activation of RhoA/ROCK-2/moesin cascade.	BMC Cancer	2010 Apr 29	He M	doi: 10.1186/1471-2407-10-170.
18695890	The expression and prognostic value of ROCK I and ROCK II and their role in human breast cancer.	Int J Oncol	2008 Sep	Lane J	-
21084279	BRCA2 and nucleophosmin coregulate centrosome amplification and form a complex with the Rho effector kinase ROCK2.	Cancer Res	2011 Jan 1	Wang HF	doi: 10.1158/0008-5472.CAN-10-0030
27203208	Inhibitors of Rho kinase (ROCK) signaling revert the malignant phenotype of breast cancer cells in 3D context.	Oncotarget	2016 May 31	Matsubara M	doi: 10.18632/oncotarget.9395.
27374095	Integrated in vivo genetic and pharmacologic screening identifies co-inhibition of EGRF and ROCK as a potential treatment regimen for triple-negative breast cancer.	Oncotarget	2016 Jul 12	Iskit S	doi: 10.18632/oncotarget.10230.
29990315	Overexpression of Rho-Associated Coiled-Coil Containing Protein Kinase 2 Is Correlated with Clinical Progression and Poor Prognosis in Breast Cancer.	Med Sci Monit	2018 Jul 10	Yi H	doi: 10.12659/MSM.908507.
28653604	MicroRNA-139-5p Inhibits Cell Proliferation and Invasion by Targeting RHO-Associated Coiled-Coil-Containing Protein Kinase 2 in Ovarian Cancer.	Oncol Res	2018 Apr 10	Wang Y	doi: 10.3727/096504017X14974343584989

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr2	11216166	Missense_Mutation	novel	E485K	0.23
BLCA	chr2	11192481	Missense_Mutation	novel	K1307E	0.24
BLCA	chr2	11214927	Missense_Mutation	NA	E617Q	0.06
BLCA	chr2	11198757	Silent	NA	R976R	0.29
BLCA	chr2	11214460	Missense_Mutation	novel	R647T	0.17
BLCA	chr2	11221305	Silent	rs187386683	F384F	0.12
BLCA	chr2	11227286	Missense_Mutation	NA	S279F	0.32
BLCA	chr2	11287665	Missense_Mutation	NA	F71L	0.18
BLCA	chr2	11201057	Missense_Mutation	novel	S937C	0.62
BLCA	chr2	11193790	Missense_Mutation	NA	R1226G	0.39
BLCA	chr2	11192226	Missense_Mutation	novel	S1362C	0.22
BLCA	chr2	11227344	Missense_Mutation	novel	E260Q	0.13
BLCA	chr2	11214876	Missense_Mutation	novel	R634G	0.08
BLCA	chr2	11211787	Silent	novel	Q699Q	0.37
BLCA	chr2	11198502	Missense_Mutation	novel	L1030V	0.07
BLCA	chr2	11227257	Missense_Mutation	novel	V289L	0.3
BLCA	chr2	11227253	Splice_Site	NA	X290_splice	0.18
BLCA	chr2	11207887	Missense_Mutation	NA	I796M	0.06
BLCA	chr2	11286586	Missense_Mutation	novel	D93N	0.18
BRCA	chr2	11192220	Missense_Mutation	NA	R1364T	0.16
BRCA	chr2	11198579	Nonsense_Mutation	NA	S1004*	0.28
BRCA	chr2	11182970	3'UTR	novel		0.1
BRCA	chr2	11182953	3'UTR	novel		0.09
BRCA	chr2	11182970	3'UTR	novel		0.11
BRCA	chr2	11182970	3'UTR	novel		0.12
BRCA	chr2	11198707	Frame_Shift_Del	novel	*N993Ifs4**	0.12
BRCA	chr2	11192297	Silent	NA	Q1338Q	0.22
BRCA	chr2	11287692	Missense_Mutation	novel	L62F	0.25
BRCA	chr2	11197579	Missense_Mutation	NA	K1076Q	0.31
BRCA	chr2	11215061	Missense_Mutation	rs747260728	R572Q	0.24
BRCA	chr2	11202085	Silent	novel	L862L	0.1
BRCA	chr2	11194304	Missense_Mutation	NA	S1187N	0.73
BRCA	chr2	11201367	Nonsense_Mutation	novel	*E889Afs3**	0.04
BRCA	chr2	11201369	Frame_Shift_Ins	novel	*E888Dfs8**	0.01
BRCA	chr2	11208322	Missense_Mutation	novel	E777Q	0.17
BRCA	chr2	11215034	Nonsense_Mutation	NA	L581*	0.39
CESC	chr2	11207880	Nonsense_Mutation	novel	E799*	0.08
CESC	chr2	11182953	3'UTR	novel		0.14
CESC	chr2	11215543	Nonsense_Mutation	novel	E522*	0.08
CESC	chr2	11201314	Missense_Mutation	NA	E907K	0.18
CESC	chr2	11216163	Missense_Mutation	NA	E486Q	0.42
CESC	chr2	11182953	3'UTR	novel		0.09
CESC	chr2	11192460	Missense_Mutation	NA	P1314S	0.1
CESC	chr2	11182953	3'UTR	novel		0.2
CESC	chr2	11182953	3'UTR	novel		0.13
CESC	chr2	11192476	Frame_Shift_Ins	NA	*E1309Gfs12**	0.41
CESC	chr2	11235713	Missense_Mutation	novel	K238Q	0.35
CESC	chr2	11182953	3'UTR	novel		0.11
CESC	chr2	11182953	3'UTR	novel		0.18
CESC	chr2	11201347	Frame_Shift_Del	novel	*E896Nfs24**	0.06
CESC	chr2	11182953	3'UTR	novel		0.08
CESC	chr2	11182953	3'UTR	novel		0.17
CESC	chr2	11182953	3'UTR	novel		0.16
CESC	chr2	11249663	Nonsense_Mutation	novel	Q154*	0.24
CESC	chr2	11197552	Missense_Mutation	rs376988314	Q1085E	0.21
CHOL	chr2	11182953	3'UTR	novel		0.15
COAD	chr2	11249711	Frame_Shift_Del	rs755738345	*W138Gfs31**	0.41
COAD	chr2	11208318	Missense_Mutation	NA	L778P	0.34
COAD	chr2	11235748	Missense_Mutation	NA	G226E	0.06
COAD	chr2	11192624	Missense_Mutation	NA	K1259M	0.18
COAD	chr2	11197537	Nonsense_Mutation	NA	E1090*	0.43
COAD	chr2	11211760	Silent	NA	H708H	0.14
COAD	chr2	11286619	Frame_Shift_Del	novel	*I82Sfs6**	0.12
COAD	chr2	11216178	Missense_Mutation	NA	A481T	0.21
COAD	chr2	11192259	Frame_Shift_Del	NA	*K1351Sfs17**	0.34
COAD	chr2	11249704	Missense_Mutation	NA	E140G	0.06
COAD	chr2	11211799	Missense_Mutation	NA	K695N	0.09
COAD	chr2	11222166	Missense_Mutation	NA	R339Q	0.17
COAD	chr2	11224342	Silent	NA	I329I	0.09
COAD	chr2	11201347	Nonsense_Mutation	NA	E896*	0.34
COAD	chr2	11222166	Missense_Mutation	NA	R339Q	0.39
COAD	chr2	11287678	Missense_Mutation	NA	N67T	0.36
COAD	chr2	11201020	Missense_Mutation	NA	E949D	0.26
COAD	chr2	11183363	3'UTR	rs1048715		0.29
COAD	chr2	11211834	Frame_Shift_Del	NA	*S684Afs5**	0.34
COAD	chr2	11197619	Missense_Mutation	NA	E1062D	0.18
COAD	chr2	11214932	Nonsense_Mutation	NA	*K615Mfs4**	0.27
COAD	chr2	11192254	Missense_Mutation	NA	P1353T	0.19
COAD	chr2	11198763	Silent	NA	T974T	0.12
COAD	chr2	11215589	Silent	rs753996403	A506A	0.33
ESCA	chr2	11211709	Silent	rs770615625	I725I	0.15
ESCA	chr2	11182953	3'UTR	novel		0.14
ESCA	chr2	11182953	3'UTR	novel		0.08
ESCA	chr2	11192487	Missense_Mutation	novel	M1305V	0.2
ESCA	chr2	11215513	Missense_Mutation	novel	D532Y	0.25
ESCA	chr2	11182953	3'UTR	novel		0.11
ESCA	chr2	11192540	Missense_Mutation	novel	P1287L	0.39
GBM	chr2	11192508	Missense_Mutation	novel	I1298V	0.05
GBM	chr2	11197570	Missense_Mutation	novel	Q1079K	0.06
GBM	chr2	11202069	Missense_Mutation	novel	A868S	0.05
GBM	chr2	11215046	Missense_Mutation	novel	T577S	0.38
GBM	chr2	11192175	Missense_Mutation	NA	S1379N	0.39
GBM	chr2	11193828	Missense_Mutation	novel	Q1213L	0.46
HNSC	chr2	11201057	Missense_Mutation	novel	S937C	0.1
HNSC	chr2	11215561	Missense_Mutation	novel	Q516E	0.18
HNSC	chr2	11214441	Silent	novel	E653E	0.23
HNSC	chr2	11201038	Silent	novel	K943K	0.32
HNSC	chr2	11249711	Frame_Shift_Del	rs755738345	*W138Gfs31**	0.25
HNSC	chr2	11221222	Missense_Mutation	novel	G412A	0.18
HNSC	chr2	11198587	Splice_Site	novel	X1002_splice	0.21
HNSC	chr2	11197323	Missense_Mutation	novel	R1102Q	0.23
HNSC	chr2	11183297	3'UTR	novel		0.12
HNSC	chr2	11192278	Missense_Mutation	rs374395637	V1345M	0.04
HNSC	chr2	11227395	Missense_Mutation	novel	G243S	0.28
HNSC	chr2	11224452	Missense_Mutation	novel	P293T	0.09
HNSC	chr2	11235899	Missense_Mutation	novel	D176N	0.29
HNSC	chr2	11192234	Silent	novel	A1359A	0.25
HNSC	chr2	11214357	Splice_Region	novel	K681K	0.29
KIRC	chr2	11221254	Silent	NA	K401K	0.23
KIRC	chr2	11249682	Frame_Shift_Del	novel	*F146Ifs21**	0.31
KIRC	chr2	11201358	Frame_Shift_Ins	novel	*K892Tfs35**	0.04
KIRC	chr2	11211770	Frame_Shift_Ins	novel	*E705Vfs7**	0.05
KIRP	chr2	11235911	Missense_Mutation	rs199740035	M172L	0.04
KIRP	chr2	11193806	Silent	rs760119387	D1220D	0.5
LAML	chr2	11235856	Nonsense_Mutation	novel	W190*	0.03
LAML	chr2	11201311	Missense_Mutation	novel	R908W	0.11
LGG	chr2	11208342	Frame_Shift_Del	novel	*K769Sfs6**	0.13
LGG	chr2	11215603	Frame_Shift_Del	novel	*L501Kfs35**	0.06
LGG	chr2	11208377	Missense_Mutation	novel	E758D	0.26
LGG	chr2	11215391	Missense_Mutation	NA	L540H	0.46
LGG	chr2	11287687	Missense_Mutation	novel	K64R	0.35
LIHC	chr2	11235818	Missense_Mutation	NA	D203N	0.51
LIHC	chr2	11200975	Silent	novel	K964K	0.06
LIHC	chr2	11197350	Splice_Site	NA	X1094_splice	0.28
LIHC	chr2	11208321	Missense_Mutation	NA	E777V	0.4
LUAD	chr2	11192691	Missense_Mutation	novel	E1237Q	0.19
LUAD	chr2	11215647	Splice_Site	NA	X488_splice	0.26
LUAD	chr2	11286553	Missense_Mutation	novel	G104R	0.14
LUAD	chr2	11344009	Missense_Mutation	NA	V43E	0.36
LUAD	chr2	11192143	Splice_Site	novel	X1388_splice	0.29
LUAD	chr2	11344124	Missense_Mutation	NA	P5S	0.38
LUAD	chr2	11227349	Missense_Mutation	NA	S258L	0.16
LUAD	chr2	11235743	Silent	novel	L228L	0.26
LUSC	chr2	11202106	Silent	rs776881617	A855A	0.09
LUSC	chr2	11216202	Missense_Mutation	novel	V473F	0.18
LUSC	chr2	11215024	Silent	novel	T584T	0.28
LUSC	chr2	11207852	Missense_Mutation	novel	N808S	0.17
LUSC	chr2	11197589	Silent	novel	S1072S	0.26
LUSC	chr2	11197590	Missense_Mutation	novel	S1072C	0.05
LUSC	chr2	11201070	Nonsense_Mutation	novel	E933*	0.04
LUSC	chr2	11192270	Missense_Mutation	novel	K1347N	0.03
LUSC	chr2	11286544	Nonsense_Mutation	NA	Q107*	0.06
LUSC	chr2	11183429	3'UTR	novel		0.18
LUSC	chr2	11192505	Frame_Shift_Ins	novel	*K1299Afs20**	0.27
LUSC	chr2	11227380	Missense_Mutation	novel	D248H	0.32
LUSC	chr2	11192196	Frame_Shift_Del	novel	*N1372Tfs22**	0.19
LUSC	chr2	11215074	Missense_Mutation	novel	N568D	0.19
LUSC	chr2	11200989	Missense_Mutation	novel	E960K	0.15
OV	chr2	11344023	Silent	novel	R38R	0.23
OV	chr2	11182953	3'UTR	novel		0.08
OV	chr2	11182953	3'UTR	novel		0.12
OV	chr2	11214941	Missense_Mutation	NA	A612V	0.36
OV	chr2	11216169	Missense_Mutation	NA	L484V	0.14
OV	chr2	11201323	Missense_Mutation	novel	L904V	0.19
OV	chr2	11344044	Silent	novel	E31E	0.19
OV	chr2	11182970	3'UTR	novel		0.08
OV	chr2	11215378	Silent	novel	K544K	0.07
PAAD	chr2	11197236	Missense_Mutation	novel	D1131G	0.29
PCPG	chr2	11193841	Nonsense_Mutation	rs764405852	R1209*	0.11
PRAD	chr2	11235882	Missense_Mutation	novel	M181I	0.4
READ	chr2	11192284	Missense_Mutation	NA	R1343W	0.29
READ	chr2	11183394	3'UTR	novel		0.3
READ	chr2	11215521	Frame_Shift_Del	NA	*L529Wfs8**	0.36
READ	chr2	11194317	Missense_Mutation	NA	L1183F	0.46
READ	chr2	11198714	Nonsense_Mutation	NA	E991*	0.4
READ	chr2	11202072	Missense_Mutation	NA	E867K	0.39
READ	chr2	11211748	Missense_Mutation	NA	K712N	0.28
READ	chr2	11207787	Nonsense_Mutation	NA	E830*	0.26
READ	chr2	11211735	Missense_Mutation	novel	D717N	0.34
READ	chr2	11227358	Missense_Mutation	NA	D255V	0.33
SARC	chr2	11182953	3'UTR	novel		0.1
SARC	chr2	11182953	3'UTR	novel		0.12
SARC	chr2	11224358	Missense_Mutation	novel	H324L	0.12
SARC	chr2	11182953	3'UTR	novel		0.08
SARC	chr2	11182953	3'UTR	novel		0.09
SARC	chr2	11182953	3'UTR	novel		0.12
SARC	chr2	11182953	3'UTR	novel		0.09
SARC	chr2	11182953	3'UTR	novel		0.19
SARC	chr2	11182953	3'UTR	novel		0.16
SARC	chr2	11182953	3'UTR	novel		0.12
SARC	chr2	11182953	3'UTR	novel		0.19
SARC	chr2	11182953	3'UTR	novel		0.1
SARC	chr2	11182953	3'UTR	novel		0.16
SKCM	chr2	11214450	Silent	novel	G650G	0.24
SKCM	chr2	11193842	Silent	NA	V1208V	0.22
SKCM	chr2	11222127	Missense_Mutation	NA	P352L	0.43
SKCM	chr2	11249761	Missense_Mutation	NA	K121T	0.08
SKCM	chr2	11197183	Missense_Mutation	NA	P1149S	0.18
SKCM	chr2	11211744	Nonsense_Mutation	NA	R714*	0.32
SKCM	chr2	11227357	Missense_Mutation	NA	D255E	0.13
SKCM	chr2	11249658	Splice_Region	rs750095387		0.1
SKCM	chr2	11235947	Nonsense_Mutation	NA	Q160*	0.11
SKCM	chr2	11227273	Silent	NA	F283F	0.19
SKCM	chr2	11194257	In_Frame_Ins	novel	L1200_I1202dup	0.4
SKCM	chr2	11227273	Silent	NA	F283F	0.2
SKCM	chr2	11197258	Nonsense_Mutation	novel	Q1124*	0.37
SKCM	chr2	11197259	Silent	rs768505489	L1123L	0.38
SKCM	chr2	11198753	Missense_Mutation	NA	L978I	0.35
SKCM	chr2	11192589	Missense_Mutation	NA	P1271S	0.31
SKCM	chr2	11192241	Missense_Mutation	NA	P1357L	0.28
SKCM	chr2	11287716	Silent	novel	V54V	0.17
SKCM	chr2	11344094	Missense_Mutation	novel	E15K	0.45
SKCM	chr2	11215040	Missense_Mutation	NA	A579V	0.14
SKCM	chr2	11249710	Frame_Shift_Ins	NA	*W138Lfs12**	0.23
SKCM	chr2	11224322	Missense_Mutation	NA	R336K	0.31
SKCM	chr2	11249718	Silent	NA	A135A	0.29
SKCM	chr2	11192219	Silent	novel	R1364R	0.52
STAD	chr2	11192259	Frame_Shift_Del	NA	*K1351Sfs17**	0.29
STAD	chr2	11218987	Silent	NA	S433S	0.47
STAD	chr2	11211679	Splice_Site	NA	X735_splice	0.2
STAD	chr2	11192271	Frame_Shift_Del	novel	*K1347Rfs21**	0.34
STAD	chr2	11216193	Missense_Mutation	NA	R476C	0.38
STAD	chr2	11211790	Silent	NA	Q698Q	0.31
STAD	chr2	11215397	Missense_Mutation	novel	D538V	0.27
STAD	chr2	11207810	Frame_Shift_Ins	novel	*M822Nfs11**	0.39
STAD	chr2	11214990	Nonsense_Mutation	novel	E596*	0.42
STAD	chr2	11207798	Frame_Shift_Del	novel	*L820Vfs6**	0.31
STAD	chr2	11287690	Missense_Mutation	NA	R63K	0.25
STAD	chr2	11208354	Missense_Mutation	NA	C766Y	0.17
STAD	chr2	11249711	Frame_Shift_Del	rs755738345	*W138Gfs31**	0.17
STAD	chr2	11222046	Splice_Site	novel	X363_splice	0.29
STAD	chr2	11235738	Frame_Shift_Del	novel	*K229Nfs2**	0.08
STAD	chr2	11192259	Frame_Shift_Del	NA	*K1351Sfs17**	0.25
STAD	chr2	11249711	Frame_Shift_Del	rs755738345	*W138Gfs31**	0.25
STAD	chr2	11192332	Missense_Mutation	NA	L1327V	0.14
STAD	chr2	11215374	Frame_Shift_Del	novel	*R546Efs12**	0.13
STAD	chr2	11227322	Frame_Shift_Del	novel	*G267Vfs14**	0.19
STAD	chr2	11198559	Frame_Shift_Del	novel	E1010*	0.31
STAD	chr2	11249711	Frame_Shift_Del	rs755738345	*W138Gfs31**	0.29
STAD	chr2	11344109	Frame_Shift_Del	novel	*M10Cfs24**	0.7
TGCT	chr2	11215051	Frame_Shift_Del	novel	S575*	0.22
THYM	chr2	11182953	3'UTR	novel		0.2
THYM	chr2	11182953	3'UTR	novel		0.11
THYM	chr2	11182953	3'UTR	novel		0.05
THYM	chr2	11182953	3'UTR	novel		0.13
UCEC	chr2	11195019	Missense_Mutation	NA	R1152K	0.31
UCEC	chr2	11193847	Missense_Mutation	novel	H1207Y	0.23
UCEC	chr2	11214875	Missense_Mutation	novel	R634Q	0.29
UCEC	chr2	11249782	Missense_Mutation	novel	S114L	0.21
UCEC	chr2	11192271	Frame_Shift_Del	novel	*K1347Rfs21**	0.38
UCEC	chr2	11214958	Missense_Mutation	novel	N606K	0.18
UCEC	chr2	11192502	Missense_Mutation	NA	C1300R	0.28
UCEC	chr2	11211840	Missense_Mutation	NA	E682K	0.13
UCEC	chr2	11227360	Silent	NA	P254P	0.53
UCEC	chr2	11235856	Frame_Shift_Ins	novel	*W190Lfs8**	0.34
UCEC	chr2	11287673	Missense_Mutation	NA	D69Y	0.46
UCEC	chr2	11218452	Splice_Region	novel		0.31
UCEC	chr2	11227359	Missense_Mutation	novel	D255N	0.33
UCEC	chr2	11235784	Missense_Mutation	novel	D214G	0.21
UCEC	chr2	11287735	Missense_Mutation	novel	D48A	0.37
UCEC	chr2	11222091	Missense_Mutation	novel	I364T	0.11
UCEC	chr2	11182995	3'UTR	novel		0.24
UCEC	chr2	11192673	Nonsense_Mutation	NA	E1243*	0.47
UCEC	chr2	11201363	Missense_Mutation	NA	K890N	0.03
UCEC	chr2	11182970	3'UTR	rs3755255		0.42
UCEC	chr2	11197578	Missense_Mutation	novel	K1076T	0.12
UCEC	chr2	11182982	3'UTR	novel		0.2
UCEC	chr2	11198498	Missense_Mutation	novel	K1031R	0.25
UCEC	chr2	11197324	Nonsense_Mutation	NA	R1102*	0.18
UCEC	chr2	11211759	Missense_Mutation	NA	K709E	0.18
UCEC	chr2	11201044	Silent	NA	K941K	0.11
UCEC	chr2	11183400	3'UTR	novel		0.29
UCEC	chr2	11192555	Nonsense_Mutation	novel	W1282*	0.19
UCEC	chr2	11201372	Silent	novel	C887C	0.1
UCEC	chr2	11197323	Missense_Mutation	novel	R1102Q	0.5
UCEC	chr2	11198584	Missense_Mutation	novel	Q1002H	0.06
UCEC	chr2	11214840	Missense_Mutation	NA	G646S	0.36
UCEC	chr2	11182970	3'UTR	rs3755255		0.35
UCEC	chr2	11224350	Missense_Mutation	novel	N327H	0.31
UCEC	chr2	11222146	Nonsense_Mutation	novel	E346*	0.36
UCEC	chr2	11287732	Missense_Mutation	novel	G49D	0.25
UCEC	chr2	11182641	3'UTR	novel		0.34
UCEC	chr2	11287737	Splice_Site	novel	X48_splice	0.35
UCEC	chr2	11249710	Frame_Shift_Ins	NA	*W138Lfs12**	0.43
UCEC	chr2	11182953	3'UTR	novel		0.15
UCEC	chr2	11287726	Missense_Mutation	novel	N51I	0.14
UCEC	chr2	11207784	Missense_Mutation	novel	N831H	0.41
UCEC	chr2	11216198	Missense_Mutation	novel	N474T	0.11
UCEC	chr2	11182953	3'UTR	novel		0.58
UCEC	chr2	11182938	3'UTR	novel		0.11
UCEC	chr2	11192232	Missense_Mutation	rs758748287	R1360Q	0.11
UCEC	chr2	11192601	Missense_Mutation	rs772794414	L1267F	0.4
UCEC	chr2	11215642	Missense_Mutation	novel	T489A	0.07
UCEC	chr2	11183081	3'UTR	novel		0.26
UCEC	chr2	11197546	Nonsense_Mutation	novel	E1087*	0.13
UCEC	chr2	11214376	Missense_Mutation	novel	R675I	0.42
UCEC	chr2	11222143	Nonsense_Mutation	novel	E347*	0.45
UCEC	chr2	11201393	Silent	novel	V880V	0.27
UCEC	chr2	11249711	Frame_Shift_Del	rs755738345	*W138Gfs31**	0.24
UCEC	chr2	11183400	3'UTR	novel		0.42
UCEC	chr2	11201377	Nonsense_Mutation	novel	E886*	0.12
UCEC	chr2	11202072	Missense_Mutation	NA	E867K	0.22
UCEC	chr2	11222166	Missense_Mutation	NA	R339Q	0.22
UCEC	chr2	11182970	3'UTR	rs3755255		0.33
UCEC	chr2	11197323	Missense_Mutation	novel	R1102Q	0.35
UCEC	chr2	11286618	Frame_Shift_Ins	novel	*I82Nfs12**	0.35
UCEC	chr2	11182639	3'UTR	novel		0.42
UCEC	chr2	11197669	Missense_Mutation	novel	E1046K	0.2
UCEC	chr2	11201038	Missense_Mutation	novel	K943N	0.16
UCEC	chr2	11182970	3'UTR	rs3755255		0.26
UCEC	chr2	11235863	Missense_Mutation	NA	E188K	0.33
UCEC	chr2	11200974	Frame_Shift_Ins	novel	*D965Rfs8**	0.67
UCEC	chr2	11202120	Nonsense_Mutation	novel	E851*	0.45
UCEC	chr2	11211708	Missense_Mutation	novel	E726K	0.13
UCEC	chr2	11192617	Silent	novel	H1261H	0.12
UCEC	chr2	11194989	Missense_Mutation	novel	R1162Q	0.18
UCEC	chr2	11216181	Frame_Shift_Del	novel	*T480Qfs5**	0.44
UCEC	chr2	11197340	Silent	novel	A1096A	0.05
UCEC	chr2	11197527	Missense_Mutation	NA	A1093V	0.21
UCEC	chr2	11182970	3'UTR	novel		0.1
UCEC	chr2	11208400	Nonsense_Mutation	novel	E751*	0.3
UCEC	chr2	11197603	Missense_Mutation	novel	M1068V	0.16
UCEC	chr2	11215392	Missense_Mutation	novel	L540F	0.28
UCEC	chr2	11198753	Missense_Mutation	NA	L978I	0.4
UCEC	chr2	11249711	Frame_Shift_Del	rs755738345	*W138Gfs31**	0.47
UCEC	chr2	11183275	3'UTR	novel		0.32
UCEC	chr2	11198685	Missense_Mutation	NA	Q1000H	0.44
UCEC	chr2	11194290	Nonsense_Mutation	NA	E1192*	0.27
UCEC	chr2	11182904	3'UTR	novel		0.43
UCEC	chr2	11182995	3'UTR	novel		0.35
UCEC	chr2	11211744	Nonsense_Mutation	NA	R714*	0.25
UCEC	chr2	11197702	Frame_Shift_Ins	novel	*V1035Rfs2**	0.08
UCEC	chr2	11197704	Missense_Mutation	novel	A1034G	0.06
UCEC	chr2	11193799	Nonsense_Mutation	novel	E1223*	0.07
UCEC	chr2	11183217	3'UTR	novel		0.31
UCEC	chr2	11211743	Missense_Mutation	novel	R714Q	0.14
UCEC	chr2	11197328	Missense_Mutation	NA	Q1100H	0.22
UCEC	chr2	11197542	Missense_Mutation	NA	L1088R	0.29
UCEC	chr2	11194990	Nonsense_Mutation	novel	R1162*	0.26
UCEC	chr2	11182679	3'UTR	novel		0.47
UCEC	chr2	11215590	Missense_Mutation	novel	A506V	0.49
UCEC	chr2	11227306	Silent	rs746382525	G272G	0.41
UCEC	chr2	11235955	Frame_Shift_Ins	novel	*Y157Lfs6**	0.4
UCS	chr2	11192477	Frame_Shift_Del	NA	*K1308Rfs5**	0.39
UCS	chr2	11197324	Nonsense_Mutation	NA	R1102*	0.31
UCS	chr2	11224369	Missense_Mutation	novel	E320D	0.44
UCS	chr2	11286617	Missense_Mutation	novel	I82M	0.18

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	AMP	0.2271	0.099937
KIRP	DEL	0.0278	0.08832
LUSC	DEL	0.0599	0.20634
OV	DEL	0.1589	0.087942
PAAD	DEL	0.0924	0.2014
TGCT	AMP	0.28	0.0050216
UCEC	DEL	0.0353	0.18809

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
ACC	0.0017	Kaplan-Meier Survival Analysis
SKCM	0.021	Kaplan-Meier Survival Analysis
KIRP	0.0013	Kaplan-Meier Survival Analysis
COAD	0.0084	Kaplan-Meier Survival Analysis
PAAD	0.021	Kaplan-Meier Survival Analysis
CESC	0.0044	Kaplan-Meier Survival Analysis
LIHC	0.0021	Kaplan-Meier Survival Analysis
LGG	0.0015	Kaplan-Meier Survival Analysis
CHOL	0.015	Kaplan-Meier Survival Analysis
THCA	0.046	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000134318 (Gene tree)
Gene ID: 9475
Gene Symbol: ROCK2
Alias: N
Full Name: Rho associated coiled-coil containing protein kinase 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 168,570 bases
Position: chr2:11,179,761-11,348,330
Accession: 10252
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
25087874	Rbfox2-coordinated alternative splicing of Mef2d and Rock2 controls myoblast fusion during myogenesis.	Mol Cell	2014 Aug 21	Singh RK	doi: 10.1016/j.molcel.2014.06.035

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000462366	ROCK2-206	563	-	-	- (aa)	-	-
ENST00000261535	ROCK2-201	1795	-	ENSP00000261535	446 (aa)	-	D6REE7
ENST00000401753	ROCK2-203	4017	-	ENSP00000385509	1145 (aa)	-	E9PF63
ENST00000484951	ROCK2-207	895	-	-	- (aa)	-	-
ENST00000493096	ROCK2-208	461	-	-	- (aa)	-	-
ENST00000460262	ROCK2-205	597	-	-	- (aa)	-	-
ENST00000616279	ROCK2-209	6401	-	ENSP00000481789	703 (aa)	-	Q14DU5
ENST00000315872	ROCK2-202	8292	XM_005246190	ENSP00000317985	1388 (aa)	XP_005246247	O75116
ENST00000431087	ROCK2-204	729	-	ENSP00000395957	203 (aa)	-	C9JFJ0

Gene Model

Click here to download ENSG00000134318's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04022	cGMP-PKG signaling pathway	KEGG
hsa04024	cAMP signaling pathway	KEGG
hsa04062	Chemokine signaling pathway	KEGG
hsa04071	Sphingolipid signaling pathway	KEGG
hsa04270	Vascular smooth muscle contraction	KEGG
hsa04310	Wnt signaling pathway	KEGG
hsa04360	Axon guidance	KEGG
hsa04510	Focal adhesion	KEGG
hsa04530	Tight junction	KEGG
hsa04611	Platelet activation	KEGG
hsa04670	Leukocyte transendothelial migration	KEGG
hsa04810	Regulation of actin cytoskeleton	KEGG
hsa04921	Oxytocin signaling pathway	KEGG
hsa05130	Pathogenic Escherichia coli infection	KEGG
hsa05131	Shigellosis	KEGG
hsa05132	Salmonella infection	KEGG
hsa05163	Human cytomegalovirus infection	KEGG
hsa05200	Pathways in cancer	KEGG
hsa05205	Proteoglycans in cancer	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000134318	Platelet Function Tests	6.8067110E-011	-
ENSG00000134318	Platelet Function Tests	6.8067110E-011	-
ENSG00000134318	Selenium	3.6940000E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000134318's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000134318	ROCK2	100	94.118	ENSG00000067900	ROCK1	99	65.132	Homo_sapiens
ENSG00000134318	ROCK2	98	52.206	ENSG00000198752	CDC42BPB	88	50.877	Homo_sapiens
ENSG00000134318	ROCK2	99	42.424	ENSG00000122966	CIT	90	40.455	Homo_sapiens

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001934	positive regulation of protein phosphorylation	24065547.	IMP	Process
GO:0002931	response to ischemia	-	ISS	Process
GO:0003180	aortic valve morphogenesis	-	ISS	Process
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0004674	protein serine/threonine kinase activity	16574662.21147781.	IDA	Function
GO:0004674	protein serine/threonine kinase activity	24305806.29353861.	IMP	Function
GO:0004674	protein serine/threonine kinase activity	24305806.	ISS	Function
GO:0004674	protein serine/threonine kinase activity	27853422.	NAS	Function
GO:0005198	structural molecule activity	9933571.	NAS	Function
GO:0005515	protein binding	17015463.20230755.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	-	IEA	Component
GO:0005813	centrosome	17015463.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	-	IEA	Component
GO:0006468	protein phosphorylation	18559669.	IDA	Process
GO:0006939	smooth muscle contraction	12778124.	TAS	Process
GO:0007186	G protein-coupled receptor signaling pathway	-	TAS	Process
GO:0007249	I-kappaB kinase/NF-kappaB signaling	25816133.	IMP	Process
GO:0007266	Rho protein signal transduction	-	IEA	Process
GO:0010595	positive regulation of endothelial cell migration	24065547.	IMP	Process
GO:0010613	positive regulation of cardiac muscle hypertrophy	-	ISS	Process
GO:0010628	positive regulation of gene expression	24065547.	IMP	Process
GO:0010628	positive regulation of gene expression	-	ISS	Process
GO:0010629	negative regulation of gene expression	-	ISS	Process
GO:0010825	positive regulation of centrosome duplication	-	IEA	Process
GO:0016525	negative regulation of angiogenesis	19181962.	IMP	Process
GO:0017048	Rho GTPase binding	-	IEA	Function
GO:0018105	peptidyl-serine phosphorylation	24305806.	IMP	Process
GO:0018105	peptidyl-serine phosphorylation	24305806.	ISS	Process
GO:0018107	peptidyl-threonine phosphorylation	24305806.29353861.	IMP	Process
GO:0018107	peptidyl-threonine phosphorylation	-	ISS	Process
GO:0030155	regulation of cell adhesion	12778124.	TAS	Process
GO:0030335	positive regulation of cell migration	20232393.	IMP	Process
GO:0030866	cortical actin cytoskeleton organization	25816133.	IGI	Process
GO:0030866	cortical actin cytoskeleton organization	25816133.	IMP	Process
GO:0031644	regulation of neurological system process	-	ISS	Process
GO:0032723	positive regulation of connective tissue growth factor production	-	ISS	Process
GO:0032956	regulation of actin cytoskeleton organization	12778124.	TAS	Process
GO:0035509	negative regulation of myosin-light-chain-phosphatase activity	25816133.	IGI	Process
GO:0035509	negative regulation of myosin-light-chain-phosphatase activity	25816133.	IMP	Process
GO:0036464	cytoplasmic ribonucleoprotein granule	15121898.	IDA	Component
GO:0039694	viral RNA genome replication	19376974.	IMP	Process
GO:0042752	regulation of circadian rhythm	-	ISS	Process
GO:0043410	positive regulation of MAPK cascade	-	ISS	Process
GO:0045019	negative regulation of nitric oxide biosynthetic process	29353861.	IMP	Process
GO:0045019	negative regulation of nitric oxide biosynthetic process	-	ISS	Process
GO:0045616	regulation of keratinocyte differentiation	19997641.	IMP	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0048010	vascular endothelial growth factor receptor signaling pathway	-	TAS	Process
GO:0048013	ephrin receptor signaling pathway	-	TAS	Process
GO:0048156	tau protein binding	28386764.	NAS	Function
GO:0048511	rhythmic process	-	IEA	Process
GO:0050321	tau-protein kinase activity	28386764.	NAS	Function
GO:0051246	regulation of protein metabolic process	24305806.	ISS	Process
GO:0051298	centrosome duplication	17015463.	IMP	Process
GO:0051492	regulation of stress fiber assembly	12778124.	TAS	Process
GO:0051496	positive regulation of stress fiber assembly	20232393.	IMP	Process
GO:0051893	regulation of focal adhesion assembly	12778124.	TAS	Process
GO:0061157	mRNA destabilization	-	ISS	Process
GO:0070168	negative regulation of biomineral tissue development	-	ISS	Process
GO:0071394	cellular response to testosterone stimulus	24065547.	IMP	Process
GO:0071559	response to transforming growth factor beta	-	ISS	Process
GO:0072518	Rho-dependent protein serine/threonine kinase activity	24065547.	IMP	Function
GO:0072518	Rho-dependent protein serine/threonine kinase activity	28679962.	TAS	Function
GO:0072659	protein localization to plasma membrane	25816133.	IGI	Process
GO:0072659	protein localization to plasma membrane	25816133.	IMP	Process
GO:0090271	positive regulation of fibroblast growth factor production	-	ISS	Process
GO:0097746	regulation of blood vessel diameter	-	ISS	Process
GO:0110061	regulation of angiotensin-activated signaling pathway	-	ISS	Process
GO:0150033	negative regulation of protein localization to lysosome	24305806.	IMP	Process
GO:1900037	regulation of cellular response to hypoxia	-	ISS	Process
GO:1902004	positive regulation of amyloid-beta formation	24305806.	IMP	Process
GO:1902004	positive regulation of amyloid-beta formation	24305806.	ISS	Process
GO:1902961	positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	24305806.	IMP	Process
GO:1902961	positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	24305806.	ISS	Process
GO:1902966	positive regulation of protein localization to early endosome	24305806.	IMP	Process
GO:1902993	positive regulation of amyloid precursor protein catabolic process	24305806.	IMP	Process
GO:1902993	positive regulation of amyloid precursor protein catabolic process	24305806.	ISS	Process
GO:1903140	regulation of establishment of endothelial barrier	25816133.	IGI	Process
GO:1903140	regulation of establishment of endothelial barrier	25816133.	IMP	Process
GO:1903347	negative regulation of bicellular tight junction assembly	25816133.	IGI	Process
GO:1905145	cellular response to acetylcholine	-	ISS	Process
GO:1905205	positive regulation of connective tissue replacement	-	ISS	Process
GO:1990776	response to angiotensin	-	ISS	Process
GO:2000114	regulation of establishment of cell polarity	20803696.	TAS	Process
GO:2000145	regulation of cell motility	12778124.	TAS	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

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Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.