EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24257751	Transcriptional repression of tumor suppressor CDC73, encoding an RNA polymerase II interactor, by Wilms tumor 1 protein (WT1) promotes cell proliferation: implication for cancer therapeutics.	J Biol Chem	2014 Jan 10	Rather MI	doi: 10.1074/jbc.M113.483255
15046098	Human gene mutations. Gene symbol: HRPT2. Disease: Hyperparathyroidism Jaw-tumor syndrome.	Hum Genet	2004 Jan	Teh BT	-
15046109	Human gene mutations. Gene symbol: HRPT2. Disease: Hyperparathyroidism Jaw-tumor syndrome.	Hum Genet	2004 Jan	Teh BT	-
23757631	Recurrent hyperparathyroidism and a novel nonsense mutation in a patient with hyperparathyriodism-jaw tumor syndrome.	Endocr Pract	2013 Nov-Dec	Abdulla AG	doi: 10.4158/EP13187.CR.
15613436	A Novel IVS2-1G>A mutation causes aberrant splicing of the HRPT2 gene in a family with hyperparathyroidism-jaw tumor syndrome.	J Clin Endocrinol Metab	2005 Feb	Moon SD	-
12434154	HRPT2, encoding parafibromin, is mutated in hyperparathyroidism-jaw tumor syndrome.	Nat Genet	2002 Dec	Carpten JD	-
23453027	Assessing the contribution of HRPT2 to the pathogenesis of jaw fibrous dysplasia, ossifying fibroma, and osteosarcoma.	Oral Surg Oral Med Oral Pathol Oral Radiol	2013 Mar	de Mesquita Netto AC	doi: 10.1016/j.oooo.2012.11.015.
20480190	The surgical strategy and the molecular analysis of patients with parathyroid cancer.	World J Surg	2010 Nov	Enomoto K	doi: 10.1007/s00268-010-0618-x.
15046105	Human gene mutations. Gene symbol: HRPT2. Disease: Hyperparathyroidism Jaw-tumor syndrome.	Hum Genet	2004 Jan	Teh BT	-
15046094	Human gene mutations. Gene symbol: HRPT2. Disease: Hyperparathyroidism Jaw-tumor syndrome.	Hum Genet	2004 Jan	Teh BT	-
15923622	The HRPT2 tumor suppressor gene product parafibromin associates with human PAF1 and RNA polymerase II.	Mol Cell Biol	2005 Jun	Yart A	-
15580289	Parafibromin, product of the hyperparathyroidism-jaw tumor syndrome gene HRPT2, regulates cyclin D1/PRAD1 expression.	Oncogene	2005 Feb 10	Woodard GE	-
15046107	Human gene mutations. Gene symbol: HRPT2. Disease: Hyperparathyroidism Jaw-tumor syndrome.	Hum Genet	2004 Jan	Teh BT	-
20052758	Cell division cycle protein 73 homolog (CDC73) mutations in the hyperparathyroidism-jaw tumor syndrome (HPT-JT) and parathyroid tumors.	Hum Mutat	2010 Mar	Newey PJ	doi: 10.1002/humu.21188.
15046102	Human gene mutations. Gene symbol: HRPT2. Disease: Hyperparathyroidism Jaw-tumor syndrome.	Hum Genet	2004 Jan	Teh BT	-
18755853	Clinical, genetic, and histopathologic investigation of CDC73-related familial hyperparathyroidism.	Endocr Relat Cancer	2008 Dec	Masi G	doi: 10.1677/ERC-08-0066
15046050	Human gene mutations. Gene symbol: HRPT2. Disease: Hyperparathyroidism Jaw-tumor syndrome.	Hum Genet	2004 Jan	Teh BT	-
23166327	Oncogenic microRNA-155 down-regulates tumor suppressor CDC73 and promotes oral squamous cell carcinoma cell proliferation: implications for cancer therapeutics.	J Biol Chem	2013 Jan 4	Rather MI	doi: 10.1074/jbc.M112.425736
17314275	Nuclear localization of the parafibromin tumor suppressor protein implicated in the hyperparathyroidism-jaw tumor syndrome enhances its proapoptotic function.	Mol Cancer Res	2007 Feb	Lin L	-
18987311	The parafibromin tumor suppressor protein inhibits cell proliferation by repression of the c-myc proto-oncogene.	Proc Natl Acad Sci U S A	2008 Nov 11	Lin L	doi: 10.1073/pnas.0710725105
20304979	Defective nucleolar localization and dominant interfering properties of a parafibromin L95P missense mutant causing the hyperparathyroidism-jaw tumor syndrome.	Endocr Relat Cancer	2010 May 18	Panicker LM	doi: 10.1677/ERC-09-0272
29040582	CDC73-Related Disorders: Clinical Manifestations and Case Detection in Primary Hyperparathyroidism.	J Clin Endocrinol Metab	2017 Dec 1	van der Tuin K	doi: 10.1210/jc.2017-01249.
17130827	Sporadic human renal tumors display frequent allelic imbalances and novel mutations of the HRPT2 gene.	Oncogene	2007 May 17	Zhao J	-
17555500	Identification of MEN1 and HRPT2 somatic mutations in paraffin-embedded (sporadic) parathyroid carcinomas.	Clin Endocrinol (Oxf)	2007 Sep	Haven CJ	-
28223542	The in vitro and vivo effects of nuclear and cytosolic parafibromin expression on the aggressive phenotypes of colorectal cancer cells: a search of potential gene therapy target.	Oncotarget	2017 Apr 4	Zheng HC	doi: 10.18632/oncotarget.15377.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr1	193141924	Missense_Mutation	novel	T196N	0.38
ACC	chr1	193150352	Missense_Mutation	novel	Y293D	0.44
BLCA	chr1	193203819	Missense_Mutation	novel	Q333E	0.61
BLCA	chr1	193130200	Missense_Mutation	novel	R88S	0.59
BLCA	chr1	193152403	Missense_Mutation	NA	T311A	0.59
BLCA	chr1	193150369	Missense_Mutation	novel	F298L	0.35
BLCA	chr1	193141866	Missense_Mutation	novel	M177V	0.69
BRCA	chr1	193152419	Missense_Mutation	NA	H316L	0.16
BRCA	chr1	193249849	Missense_Mutation	novel	R513W	0.45
BRCA	chr1	193203841	Missense_Mutation	novel	V340A	0.09
BRCA	chr1	193233085	Missense_Mutation	NA	G416D	0.13
BRCA	chr1	193212396	Missense_Mutation	NA	R358Q	0.18
BRCA	chr1	193122272	Missense_Mutation	novel	E24D	0.07
BRCA	chr1	193212068	Missense_Mutation	NA	S345Y	0.26
BRCA	chr1	193236291	Missense_Mutation	NA	A451V	0.25
CESC	chr1	193147924	Missense_Mutation	NA	R263C	0.18
CESC	chr1	193152393	Missense_Mutation	NA	F307L	0.4
CESC	chr1	193251086	3'UTR	novel		0.29
CESC	chr1	193136501	Intron	novel		0.52
CESC	chr1	193122221	Silent	rs769522707	V7V	0.3
CESC	chr1	193233036	In_Frame_Del	novel	N401_E402del	0.26
CESC	chr1	193251484	3'UTR	rs760275535		0.17
COAD	chr1	193150316	Missense_Mutation	rs754070093	R281C	0.27
COAD	chr1	193135392	Splice_Region	novel	S103S	0.13
COAD	chr1	193125206	Nonsense_Mutation	NA	R76*	0.29
COAD	chr1	193138128	Missense_Mutation	NA	R156H	0.26
COAD	chr1	193125209	Missense_Mutation	NA	R77C	0.2
COAD	chr1	193135434	Silent	novel	G117G	0.19
COAD	chr1	193233155	Splice_Site	novel	X439_splice	0.44
COAD	chr1	193130208	Missense_Mutation	NA	R91Q	0.28
COAD	chr1	193250745	3'UTR	novel		0.12
COAD	chr1	193130208	Missense_Mutation	NA	R91Q	0.37
COAD	chr1	193138100	Missense_Mutation	NA	R147C	0.33
COAD	chr1	193141900	Missense_Mutation	novel	K188T	0.29
COAD	chr1	193135423	Missense_Mutation	NA	L114V	0.47
COAD	chr1	193125179	Missense_Mutation	rs748952219	V67M	0.22
COAD	chr1	193147882	Frame_Shift_Ins	NA	*A251Cfs16**	0.18
ESCA	chr1	193136501	Intron	novel		0.21
ESCA	chr1	193251610	3'UTR	novel		0.07
GBM	chr1	193136578	Intron	rs779129897		0.3
GBM	chr1	193138149	Missense_Mutation	novel	G163V	0.17
GBM	chr1	193136519	Intron	novel		0.27
GBM	chr1	193212432	Missense_Mutation	novel	S370F	0.07
GBM	chr1	193130178	Frame_Shift_Ins	novel	*P84Kfs6**	0.37
HNSC	chr1	193250769	3'UTR	novel		0.13
HNSC	chr1	193135432	Missense_Mutation	novel	G117S	0.36
KIRP	chr1	193150365	Missense_Mutation	novel	R297T	0.35
KIRP	chr1	193130208	Missense_Mutation	NA	R91Q	0.09
LAML	chr1	193233080	Frame_Shift_Ins	novel	*T417Hfs4**	0.06
LGG	chr1	193249849	Missense_Mutation	novel	R513W	0.38
LGG	chr1	193141914	Missense_Mutation	novel	K193E	0.53
LGG	chr1	193141887	Missense_Mutation	NA	A184P	0.43
LIHC	chr1	193141924	Missense_Mutation	NA	T196S	0.19
LUAD	chr1	193236263	Missense_Mutation	NA	V442F	0.14
LUAD	chr1	193250748	3'UTR	novel		0.34
LUAD	chr1	193249792	Missense_Mutation	NA	V494L	0.28
LUAD	chr1	193122179	5'UTR	novel		0.11
LUAD	chr1	193152394	Missense_Mutation	novel	K308E	0.3
LUAD	chr1	193249765	Silent	rs761968225	L485L	0.11
LUAD	chr1	193142046	Missense_Mutation	NA	I237V	0.07
LUAD	chr1	193125183	Missense_Mutation	novel	H68R	0.19
LUAD	chr1	193130202	Missense_Mutation	NA	P89R	0.2
LUAD	chr1	193249803	Missense_Mutation	NA	L497F	0.07
LUAD	chr1	193147922	Missense_Mutation	novel	G262V	0.22
LUSC	chr1	193233058	Missense_Mutation	novel	R407I	0.11
LUSC	chr1	193135543	Missense_Mutation	novel	R126L	0.1
LUSC	chr1	193236279	Missense_Mutation	novel	V447E	0.16
LUSC	chr1	193122210	Missense_Mutation	novel	V4M	0.82
LUSC	chr1	193142066	Missense_Mutation	NA	K243N	0.17
LUSC	chr1	193212420	Missense_Mutation	novel	A366V	0.22
LUSC	chr1	193249763	Missense_Mutation	NA	R484L	0.62
LUSC	chr1	193249825	Missense_Mutation	novel	H505Y	0.34
LUSC	chr1	193249768	Missense_Mutation	novel	D486Y	0.09
MESO	chr1	193141860	In_Frame_Del	novel	A176_E180del	0.06
OV	chr1	193130201	Missense_Mutation	NA	P89A	0.23
PAAD	chr1	193250751	3'UTR	NA		0.19
PAAD	chr1	193135442	Missense_Mutation	novel	R120Q	0.25
PAAD	chr1	193141908	Missense_Mutation	novel	A191T	0.19
PAAD	chr1	193147961	Missense_Mutation	novel	P275L	0.24
PAAD	chr1	193141893	Missense_Mutation	novel	K186E	0.15
PAAD	chr1	193203793	Splice_Site	novel	X325_splice	0.11
PCPG	chr1	193250696	Nonsense_Mutation	novel	S527*	0.09
PRAD	chr1	193141986	Missense_Mutation	novel	E217Q	0.32
PRAD	chr1	193125210	Missense_Mutation	novel	R77H	0.34
READ	chr1	193135403	Missense_Mutation	NA	S107I	0.21
READ	chr1	193135582	Missense_Mutation	NA	R139Q	0.2
READ	chr1	193135582	Missense_Mutation	NA	R139Q	0.19
READ	chr1	193250769	3'UTR	novel		0.32
READ	chr1	193150379	Nonsense_Mutation	NA	E302*	0.31
SKCM	chr1	193135396	Missense_Mutation	novel	S105P	0.07
SKCM	chr1	193150307	Missense_Mutation	NA	P278S	0.12
SKCM	chr1	193141852	Missense_Mutation	novel	S172F	0.14
SKCM	chr1	193236307	Silent	NA	G456G	0.35
SKCM	chr1	193233061	Missense_Mutation	novel	R408I	0.21
SKCM	chr1	193122327	Missense_Mutation	novel	W43R	0.51
SKCM	chr1	193212460	Silent	NA	D379D	0.15
SKCM	chr1	193152443	Missense_Mutation	novel	T324M	0.23
STAD	chr1	193250681	Missense_Mutation	novel	M522T	0.17
STAD	chr1	193135441	Nonsense_Mutation	NA	R120*	0.33
STAD	chr1	193236262	Silent	rs747780211	R441R	0.23
STAD	chr1	193236264	Missense_Mutation	NA	V442G	0.32
STAD	chr1	193130208	Missense_Mutation	NA	R91Q	0.22
STAD	chr1	193142054	Missense_Mutation	NA	Q239H	0.51
STAD	chr1	193122196	5'UTR	novel		0.09
STAD	chr1	193125123	Missense_Mutation	NA	E48G	0.1
STAD	chr1	193138100	Missense_Mutation	NA	R147C	0.24
STAD	chr1	193130242	Splice_Region	rs141131532	A102A	0.31
STAD	chr1	193250789	3'UTR	novel		0.16
STAD	chr1	193152426	Missense_Mutation	novel	M318I	0.23
UCEC	chr1	193122075	5'UTR	novel		0.4
UCEC	chr1	193135582	Missense_Mutation	NA	R139Q	0.38
UCEC	chr1	193236272	Missense_Mutation	rs368442389	V445I	0.33
UCEC	chr1	193249804	Nonsense_Mutation	NA	E498*	0.34
UCEC	chr1	193250709	Silent	novel	F531F	0.3
UCEC	chr1	193251039	3'UTR	novel		0.27
UCEC	chr1	193251729	3'UTR	novel		0.13
UCEC	chr1	193135581	Nonsense_Mutation	novel	R139*	0.16
UCEC	chr1	193141901	Missense_Mutation	NA	K188N	0.42
UCEC	chr1	193150354	Nonsense_Mutation	NA	Y293*	0.33
UCEC	chr1	193233144	Missense_Mutation	novel	P436S	0.39
UCEC	chr1	193130228	Missense_Mutation	novel	L98F	0.16
UCEC	chr1	193135574	Missense_Mutation	novel	K136N	0.04
UCEC	chr1	193141918	Missense_Mutation	NA	R194I	0.36
UCEC	chr1	193233012	Missense_Mutation	NA	K392Q	0.32
UCEC	chr1	193236290	Missense_Mutation	novel	A451T	0.43
UCEC	chr1	193122223	Missense_Mutation	novel	L8P	0.3
UCEC	chr1	193135417	Missense_Mutation	NA	A112T	0.24
UCEC	chr1	193203813	Missense_Mutation	NA	K331E	0.28
UCEC	chr1	193130202	Missense_Mutation	NA	P89L	0.2
UCEC	chr1	193125199	Silent	NA	V73V	0.41
UCEC	chr1	193125208	Silent	NA	R76R	0.12
UCEC	chr1	193236305	Missense_Mutation	NA	G456C	0.28
UCEC	chr1	193141974	Missense_Mutation	novel	F213V	0.33
UCEC	chr1	193249762	Missense_Mutation	NA	R484C	0.38
UCEC	chr1	193250937	3'UTR	novel		0.35
UCEC	chr1	193138100	Missense_Mutation	NA	R147C	0.35
UCEC	chr1	193250870	3'UTR	novel		0.44
UCEC	chr1	193250886	3'UTR	novel		0.25
UCEC	chr1	193152379	Splice_Site	novel	X303_splice	0.46
UCEC	chr1	193130192	Missense_Mutation	novel	V86F	0.35
UCEC	chr1	193130241	Missense_Mutation	rs778134705	A102V	0.39
UCEC	chr1	193122142	5'UTR	novel		0.52
UCEC	chr1	193141918	Missense_Mutation	NA	R194I	0.31
UCEC	chr1	193142037	Nonsense_Mutation	NA	R234*	0.4
UCEC	chr1	193147881	Missense_Mutation	novel	N248K	0.2
UCEC	chr1	193130208	Missense_Mutation	NA	R91Q	0.3
UCEC	chr1	193141879	Missense_Mutation	novel	K181T	0.24
UCEC	chr1	193147866	Splice_Site	NA	X244_splice	0.53
UCEC	chr1	193150374	Missense_Mutation	novel	G300E	0.23
UCEC	chr1	193135590	Splice_Site	novel	X141_splice	0.36
UCEC	chr1	193141867	Missense_Mutation	novel	M177T	0.25
UCEC	chr1	193136501	Intron	novel		0.3
UCEC	chr1	193135582	Missense_Mutation	NA	R139Q	0.45
UCEC	chr1	193251102	3'UTR	rs576486752		0.37
UCEC	chr1	193212395	Nonsense_Mutation	rs771907995	R358*	0.46
UCEC	chr1	193141951	Missense_Mutation	NA	I205T	0.22
UCEC	chr1	193233030	Nonsense_Mutation	NA	Q398*	0.14
UCEC	chr1	193251399	3'UTR	novel		0.15
UCEC	chr1	193122254	Silent	novel	I18I	0.37
UCEC	chr1	193236263	Missense_Mutation	novel	V442I	0.22
UCEC	chr1	193136577	Intron	NA		0.14
UCEC	chr1	193236272	Missense_Mutation	rs368442389	V445I	0.13
UCEC	chr1	193250697	Silent	rs141013612	S527S	0.21
UCEC	chr1	193130208	Missense_Mutation	NA	R91Q	0.37
UCEC	chr1	193147866	Splice_Site	NA	X244_splice	0.44
UCEC	chr1	193250801	3'UTR	novel		0.33
UCEC	chr1	193250940	3'UTR	novel		0.71
UCEC	chr1	193122302	Missense_Mutation	NA	K34N	0.22
UCEC	chr1	193122230	Missense_Mutation	novel	Q10H	0.13
UCEC	chr1	193125184	Silent	novel	H68H	0.12
UCEC	chr1	193136560	Intron	novel		0.23
UCEC	chr1	193138173	Missense_Mutation	NA	R171K	0.16
UCEC	chr1	193136501	Intron	novel		0.43
UCEC	chr1	193251258	3'UTR	novel		0.43
UCEC	chr1	193249798	Missense_Mutation	novel	V496I	0.09
UCS	chr1	193150363	Missense_Mutation	novel	E296D	0.24

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.0686	0.033566
DLBC	DEL	0.0417	0.0017831
KIRC	AMP	0.0871	0.059566
PAAD	AMP	0.2174	0.085665
READ	AMP	0.2667	0.14328
TGCT	AMP	0.34	0.088103
THCA	AMP	0.0501	0.075436

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
ACC	0.00051	Kaplan-Meier Survival Analysis
UCS	0.037	Kaplan-Meier Survival Analysis
SKCM	0.009	Kaplan-Meier Survival Analysis
KIRP	0.0041	Kaplan-Meier Survival Analysis
PAAD	0.016	Kaplan-Meier Survival Analysis
BLCA	0.014	Kaplan-Meier Survival Analysis
KICH	0.047	Kaplan-Meier Survival Analysis
GBM	0.00073	Kaplan-Meier Survival Analysis
LIHC	0.0028	Kaplan-Meier Survival Analysis
LGG	0.023	Kaplan-Meier Survival Analysis
THCA	0.0081	Kaplan-Meier Survival Analysis
LUAD	0.0087	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000134371 (Gene tree)
Gene ID: 79577
Gene Symbol: CDC73
Alias: parafibromin|FIHP|C1orf28|HRPT2|HRPT1
Full Name: cell division cycle 73
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 133,016 bases
Position: chr1:193,121,800-193,254,815
Accession: 16783
RBP type: non-canonical RBP
Summary: This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma. [provided by RefSeq, Jul 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
21315421	Parafibromin expression is an independent prognostic factor for colorectal carcinomas.	Hum Pathol	2011 Aug	Zheng HC	doi: 10.1016/j.humpath.2010.10.024
18987311	The parafibromin tumor suppressor protein inhibits cell proliferation by repression of the c-myc proto-oncogene.	Proc Natl Acad Sci U S A	2008 Nov 11	Lin L	doi: 10.1073/pnas.0710725105
22868760	Crystallographic analysis of the conserved C-terminal domain of transcription factor Cdc73 from Saccharomyces cerevisiae reveals a GTPase-like fold.	Acta Crystallogr D Biol Crystallogr	2012 Aug	Chen H	doi: 10.1107/S0907444912017325

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000635846	CDC73-204	3987	-	ENSP00000490035	450 (aa)	-	A0A1B0GUB2
ENST00000477868	CDC73-202	764	-	-	- (aa)	-	-
ENST00000647662	CDC73-207	1092	-	-	- (aa)	-	-
ENST00000649895	CDC73-212	2364	-	-	- (aa)	-	-
ENST00000643784	CDC73-206	1054	-	ENSP00000494944	197 (aa)	-	A0A2R8Y640
ENST00000650197	CDC73-214	2212	-	ENSP00000496929	482 (aa)	-	-
ENST00000367435	CDC73-201	5942	-	ENSP00000356405	531 (aa)	-	Q6P1J9
ENST00000649706	CDC73-211	559	-	-	- (aa)	-	-
ENST00000650099	CDC73-213	6100	-	ENSP00000498073	531 (aa)	-	UPI0000021592
ENST00000482484	CDC73-203	764	-	-	- (aa)	-	-
ENST00000649606	CDC73-209	3697	-	-	- (aa)	-	-
ENST00000649613	CDC73-210	1325	-	-	- (aa)	-	-
ENST00000643006	CDC73-205	4482	XM_006711537	ENSP00000496633	385 (aa)	XP_006711600	A0A2R8YHB3
ENST00000648071	CDC73-208	2102	-	ENSP00000497513	104 (aa)	-	-

Gene Model

Click here to download ENSG00000134371's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000134371	Body Weights and Measures	1.13419440741086E-7	17903300
ENSG00000134371	Body Weights and Measures	7.06906926927089E-7	17903300
ENSG00000134371	Blood Flow Velocity	1.8508256195491E-6	17903301
ENSG00000134371	Osteoporosis	3.50650927748931E-9	17903295
ENSG00000134371	Osteoporosis	5.02082576432229E-9	17903295
ENSG00000134371	Platelet Function Tests	6.0900000E-007	-
ENSG00000134371	Platelet Function Tests	2.9106500E-005	-
ENSG00000134371	Platelet Function Tests	1.1725300E-005	-
ENSG00000134371	Platelet Function Tests	2.1197400E-005	-
ENSG00000134371	Platelet Function Tests	2.5258500E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000134371	rs34793300	1	193159480	?	Yeast infection	28928442	[0.056-0.138] unit decrease	0.0969	EFO_0008412
ENSG00000134371	rs200922190	1	193234362	?	Ovarian disease with few adhesions	28333195	[1.10-1.33]	1.2048193	EFO_0001065

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000134371's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	18987311.	IMP	Process
GO:0000784	nuclear chromosome, telomeric region	19135898.	HDA	Component
GO:0000993	RNA polymerase II complex binding	21873635.	IBA	Function
GO:0000993	RNA polymerase II complex binding	15923622.	IDA	Function
GO:0001711	endodermal cell fate commitment	-	ISS	Process
GO:0005515	protein binding	15923622.16024656.16630820.17113272.19136632.19410543.20178742.20541477.21900206.25416956.25910212.26496610.26659056.26742426.29774127.	IPI	Function
GO:0005634	nucleus	15923622.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006366	transcription by RNA polymerase II	-	TAS	Process
GO:0006368	transcription elongation from RNA polymerase II promoter	-	TAS	Process
GO:0006378	mRNA polyadenylation	21329879.	IMP	Process
GO:0007049	cell cycle	-	IEA	Process
GO:0008285	negative regulation of cell proliferation	16989776.	IDA	Process
GO:0010390	histone monoubiquitination	16307923.	IDA	Process
GO:0016055	Wnt signaling pathway	-	IEA	Process
GO:0016567	protein ubiquitination	-	TAS	Process
GO:0016593	Cdc73/Paf1 complex	21873635.	IBA	Component
GO:0016593	Cdc73/Paf1 complex	16307923.18987311.20178742.	IDA	Component
GO:0019827	stem cell population maintenance	-	ISS	Process
GO:0030177	positive regulation of Wnt signaling pathway	16630820.	IDA	Process
GO:0031442	positive regulation of mRNA 3'-end processing	19136632.	IMP	Process
GO:0031648	protein destabilization	18987311.	IMP	Process
GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter	21873635.	IBA	Process
GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter	20178742.	IDA	Process
GO:0033523	histone H2B ubiquitination	16307923.	IDA	Process
GO:0034402	recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex	21873635.	IBA	Process
GO:0045638	negative regulation of myeloid cell differentiation	20541477.	IDA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	20178742.	IDA	Process
GO:0048147	negative regulation of fibroblast proliferation	18987311.	IMP	Process
GO:0050680	negative regulation of epithelial cell proliferation	18987311.	IMP	Process
GO:0071222	cellular response to lipopolysaccharide	-	ISS	Process
GO:1902808	positive regulation of cell cycle G1/S phase transition	15923622.	IMP	Process
GO:1904837	beta-catenin-TCF complex assembly	-	TAS	Process
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	16989776.	IDA	Process

EuRBPDB

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

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Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.