| PID | Title | Article | Time | Author | Doi |
|---|---|---|---|---|---|
| 26681652 | Promoter methylation of APC and RAR-β genes as prognostic markers in non-small cell lung cancer (NSCLC). | Exp Mol Pathol | 2016 Feb | Feng H | doi: 10.1016/j.yexmp.2015.12.005 |
| 17222366 | [Detection and significance of APC gene promoter hypermethylation in serum of breast cancer patients]. | Ai Zheng | 2007 Jan | Zhang JJ | - |
| 26073472 | Prognostic role of APC and RASSF1A promoter methylation status in cell free circulating DNA of operable gastric cancer patients. | Mutat Res | 2015 Aug | Balgkouranidou I | doi: 10.1016/j.mrfmmm.2015.05.002 |
| 18708403 | Association of genetic variation in genes implicated in the beta-catenin destruction complex with risk of breast cancer. | Cancer Epidemiol Biomarkers Prev | 2008 Aug | Wang X | doi: 10.1158/1055-9965.EPI-08-0134. |
| 19773381 | Aberrant methylation of APC, MGMT, RASSF2A, and Wif-1 genes in plasma as a biomarker for early detection of colorectal cancer. | Clin Cancer Res | 2009 Oct 1 | Lee BB | doi: 10.1158/1078-0432.CCR-09-0111 |
| 11809682 | Quantitative adenomatous polyposis coli promoter methylation analysis in tumor tissue, serum, and plasma DNA of patients with lung cancer. | Cancer Res | 2002 Jan 15 | Usadel H | - |
| 18160396 | Mitochondrial targeting of adenomatous polyposis coli protein is stimulated by truncating cancer mutations: regulation of Bcl-2 and implications for cell survival. | J Biol Chem | 2008 Feb 29 | Brocardo M | - |
| 15251938 | Prognostic DNA methylation marker in serum of cancer patients. | Ann N Y Acad Sci | 2004 Jun | M??ller HM | - |
| 21859464 | Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer? | Mol Cancer | 2011 Aug 22 | Minde DP | doi: 10.1186/1476-4598-10-101. |
| 26804172 | Adenomatous polyposis coli (APC) regulates miR17-92 cluster through β-catenin pathway in colorectal cancer. | Oncogene | 2016 Sep 1 | Li Y | doi: 10.1038/onc.2015.522 |
| 28397687 | A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC). | Elife | 2017 Apr 11 | Sandoval IT | doi: 10.7554/eLife.22706. |
| 28130546 | YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis. | Proc Natl Acad Sci U S A | 2017 Feb 14 | Taniguchi K | doi: 10.1073/pnas.1620290114 |
| 29045831 | USP7 Is a Tumor-Specific WNT Activator for APC-Mutated Colorectal Cancer by Mediating β-Catenin Deubiquitination. | Cell Rep | 2017 Oct 17 | Novellasdemunt L | doi: 10.1016/j.celrep.2017.09.072. |
| 25107489 | Promoter methylation analysis of WNT/β-catenin pathway regulators and its association with expression of DNMT1 enzyme in colorectal cancer. | J Biomed Sci | 2014 Aug 9 | Samaei NM | doi: 10.1186/s12929-014-0073-3. |
| 12374230 | Mutations of the APC gene in human sporadic colorectal cancers. | Scand J Gastroenterol | 2002 Sep | De Filippo C | - |
| 23873622 | A new germline stop codon mutation in exon 15 of the APC gene predisposing to familial adenomatous polyposis. | Int J Biol Markers | 2013 Dec 17 | Schirosi L | doi: 10.5301/jbm.5000042. |
| 23302090 | APC/β-catenin-rich complexes at membrane protrusions regulate mammary tumor cell migration and mesenchymal morphology. | BMC Cancer | 2013 Jan 9 | Odenwald MA | doi: 10.1186/1471-2407-13-12. |
| 27494112 | Expression profiles of MGMT, p16, and APC genes in tumor and matching surgical margin from patients with oral squamous cell carcinoma. | Acta Biochim Pol | 2016 | Strzelczyk JK | doi: 10.18388/abp.2015_1204 |
| 19061640 | APC is essential for targeting phosphorylated beta-catenin to the SCFbeta-TrCP ubiquitin ligase. | Mol Cell | 2008 Dec 5 | Su Y | doi: 10.1016/j.molcel.2008.10.023. |
| 19261806 | Oncogenic Adenomatous polyposis coli mutants impair the mitotic checkpoint through direct interaction with Mad2. | Mol Biol Cell | 2009 May | Zhang J | doi: 10.1091/mbc.E08-12-1206 |
| 20850014 | DNA demethylase activity maintains intestinal cells in an undifferentiated state following loss of APC. | Cell | 2010 Sep 17 | Rai K | doi: 10.1016/j.cell.2010.08.030. |
| 18770064 | Sporadic desmoid tumor in an Ashkenazi patient homozygous for the APC*I1307K gene mutation. | Acta Oncol | 2008 | Zauber P | doi: 10.1080/02841860701716900. |
| 22469663 | Identification of a Wnt-induced protein complex by affinity proteomics using an antibody that recognizes a sub-population of β-catenin. | Biochim Biophys Acta | 2012 Jul | Layton MJ | doi: 10.1016/j.bbapap.2012.03.006 |
| 19124205 | Analysis of APC, alpha-, beta-catenins, and N-cadherin protein expression in aggressive fibromatosis (desmoid tumor). | Pathol Res Pract | 2009 | Ferenc T | doi: 10.1016/j.prp.2008.11.002 |
| 14662741 | Chromosome instability in colorectal tumor cells is associated with defects in microtubule plus-end attachments caused by a dominant mutation in APC. | J Cell Biol | 2003 Dec 8 | Green RA | - |
| 21900494 | The tumor suppressor adenomatous polyposis coli controls the direction in which a cell extrudes from an epithelium. | Mol Biol Cell | 2011 Nov | Marshall TW | doi: 10.1091/mbc.E11-05-0469 |
| 16030254 | APC and EB1 function together in mitosis to regulate spindle dynamics and chromosome alignment. | Mol Biol Cell | 2005 Oct | Green RA | - |
| 19035518 | Association between adenomatosis polyposis coli functional status and microsomal prostaglandin E synthase-1 expression in colorectal cancer. | Mol Carcinog | 2009 May | Elander N | doi: 10.1002/mc.20500. |
| 20027139 | Polymorphisms in the adenomatous polyposis coli gene in Slovak families suspected of FAP. | Neuro Endocrinol Lett | 2009 | Wachsmannova-Matelova L | - |
| 15755874 | The APC tumor suppressor promotes transcription-independent apoptosis in vitro. | Mol Cancer Res | 2005 Feb | Steigerwald K | - |
| 17569124 | Clinical features of familial adenomas polyps in Chinese and establishment of its immortal lymphocyte cell lines. | World J Gastroenterol | 2007 May 28 | Cai SR | - |
| 21948542 | [Expression of DNA methylation of APC in peripheral blood and tumor tissue in patients with esophageal squamous cell carcinoma]. | Zhonghua Wei Chang Wai Ke Za Zhi | 2011 Sep | WANG CC | - |
| 20696638 | Methylated APC and GSTP1 genes in serum DNA correlate with the presence of circulating blood tumor cells and are associated with a more aggressive and advanced breast cancer disease. | Eur J Med Res | 2010 | Matuschek C | - |
| 15821699 | Hereditary colon cancer--part I. | Curr Probl Surg | 2005 Apr | Merg A | - |
| 17620292 | Impact of adenomatous polyposis coli (APC) tumor supressor gene in human colon cancer cell lines on cell cycle arrest by apigenin. | Mol Carcinog | 2007 Sep | Chung CS | - |
| 21949247 | Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/beta-catenin signaling. | Proc Natl Acad Sci U S A | 2011 Oct 11 | Scholer-Dahirel A | doi: 10.1073/pnas.1104182108 |
| 12800081 | [Expression of members of the cadherin-/catenin-protein family in juvenile angiofibromas]. | Laryngorhinootologie | 2003 May | Rippel C | - |
| 22434720 | A functional network of the tumor suppressors APC, hDlg, and PTEN, that relies on recognition of specific PDZ-domains. | J Cell Biochem | 2012 Aug | Sotelo NS | doi: 10.1002/jcb.24141. |
| 16855398 | Genomic instability in precancerous lesions before inactivation of tumor suppressors p53 and APC in patients. | Cell Cycle | 2006 Jul | Yang Y | - |
| 16699861 | Promoter methylation profile in gallbladder cancer. | J Gastroenterol | 2006 Mar | Roa JC | - |
| 20978149 | Inactivation of the APC gene is constant in adrenocortical tumors from patients with familial adenomatous polyposis but not frequent in sporadic adrenocortical cancers. | Clin Cancer Res | 2010 Nov 1 | Gaujoux S | doi: 10.1158/1078-0432.CCR-10-1497 |
| 28423402 | Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer. | J Natl Cancer Inst | 2017 Aug 1 | Zhang L | doi: 10.1093/jnci/djw332. |
| 29921377 | Role of APC-mediated MDR-1/CLCX-1 signaling pathway in ovarian tumors. | J Biol Regul Homeost Agents | 2018 May-Jun | Wang Y | - |
| 29144570 | LncAPC drives Wnt/β-catenin activation and liver TIC self-renewal through EZH2 mediated APC transcriptional inhibition. | Mol Carcinog | 2018 Mar | Fu X | doi: 10.1002/mc.22764 |
| 12378616 | Mutation analysis of APC gene in gastric cancer with microsatellite instability. | World J Gastroenterol | 2002 Oct | Fang DC | - |
| 24861525 | Genetic analysis in APC, KRAS, and TP53 in patients with stomach and colon cancer. | Rev Gastroenterol Mex | 2014 Apr-Jun | Palacio-R??a KA | doi: 10.1016/j.rgmx.2014.05.001 |
| 27191268 | Quantitative assessment of the association between APC promoter methylation and breast cancer. | Oncotarget | 2016 Jun 21 | He K | doi: 10.18632/oncotarget.9354. |
| 21995949 | Increased variance in germline allele-specific expression of APC associates with colorectal cancer. | Gastroenterology | 2012 Jan | Curia MC | doi: 10.1053/j.gastro.2011.09.048 |
| 23244118 | Colon cancer prevention by detection of APC gene mutation in a family with attenuated familial adenomatous polyposis. | Asian Pac J Cancer Prev | 2012 | Poovorawan K | - |
| 17954272 | Exclusion of APC and VHL gene deletions by array-based comparative hybridization in two patients with microscopically visible chromosomal aberrations. | Cancer Genet Cytogenet | 2007 Oct 15 | Wallerstein RJ | - |
| 16951153 | Smad3 deficiency promotes tumorigenesis in the distal colon of ApcMin/+ mice. | Cancer Res | 2006 Sep 1 | Sodir NM | - |
| 24735542 | A de novo germline mutation of APC for inheritable colon cancer in a Chinese family using multigene next generation sequencing. | Biochem Biophys Res Commun | 2014 May 9 | Zhang Y | doi: 10.1016/j.bbrc.2014.04.014 |
| 22795047 | Association of APC and REEP5 gene polymorphisms with major depression disorder and treatment response to antidepressants in a Han Chinese population. | Gen Hosp Psychiatry | 2012 Sep-Oct | Yang Z | doi: 10.1016/j.genhosppsych.2012.05.015 |
| 26884349 | Promoter methylation of ITF2, but not APC, is associated with microsatellite instability in two populations of colorectal cancer patients. | BMC Cancer | 2016 Feb 17 | Savio AJ | doi: 10.1186/s12885-016-2149-9. |
| 14729851 | Novel germline mutations in the adenomatous polyposis coli gene in Polish families with familial adenomatous polyposis. | J Med Genet | 2004 Jan | Plawski A | - |
| 23131390 | A clinical-biological risk stratification model for resected gastric cancer: prognostic impact of Her2, Fhit, and APC expression status. | Ann Oncol | 2013 Mar | Bria E | doi: 10.1093/annonc/mds506 |
| 25250560 | Identification of novel mutations by exome sequencing in African American colorectal cancer patients. | Cancer | 2015 Jan 1 | Ashktorab H | doi: 10.1002/cncr.28922 |
| 16423286 | Examination of actin and microtubule dependent APC localisations in living mammalian cells. | BMC Cell Biol | 2006 Jan 19 | Langford KJ | - |
| 18265644 | The differentially mutational spectra of the APC, K-ras, and p53 genes in sporadic colorectal cancers from Taiwanese patients. | Hepatogastroenterology | 2007 Dec | Wang JY | - |
| 22380946 | Regulation of the metabolite profile by an APC gene mutation in colorectal cancer. | Cancer Sci | 2012 Jun | Yoshie T | doi: 10.1111/j.1349-7006.2012.02262.x |
| 21680534 | Aberrant methylation of RARbeta2 and APC genes in voided urine as molecular markers for early detection of bilharzial and nonbilharzial bladder cancer. | Cancer Epidemiol Biomarkers Prev | 2011 Aug | Eissa S | doi: 10.1158/1055-9965.EPI-11-0237 |
| 23874531 | Methylation of APC and GSTP1 in non-neoplastic tissue adjacent to prostate tumour and mortality from prostate cancer. | PLoS One | 2013 Jul 9 | Richiardi L | doi: 10.1371/journal.pone.0068162 |
| 19615284 | [Correlation of BRCA1 and APC aberrant methylation with the response to anthracycline-based neoadjuvant chemotherapy in primary breast cancer]. | Zhonghua Zhong Liu Za Zhi | 2009 Apr | Yuan P | - |
| 20696900 | PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice. | Proc Natl Acad Sci U S A | 2010 Aug 24 | Poulogiannis G | doi: 10.1073/pnas.1009941107 |
| 23299921 | APC gene hypermethylation and prostate cancer: a systematic review and meta-analysis. | Eur J Hum Genet | 2013 Sep | Chen Y | doi: 10.1038/ejhg.2012.281 |
| 23087084 | miR-106b downregulates adenomatous polyposis coli and promotes cell proliferation in human hepatocellular carcinoma. | Carcinogenesis | 2013 Jan | Shen G | doi: 10.1093/carcin/bgs320 |
| 19307944 | Prognostic significance of interaction between somatic APC mutations and 5-fluorouracil adjuvant chemotherapy in Taiwanese colorectal cancer subjects. | Am J Clin Oncol | 2009 Apr | Chen SP | doi: 10.1097/COC.0b013e318181f959. |
| 22528324 | Genetic variations in stem cell-related genes and colorectal cancer prognosis. | J Gastrointest Cancer | 2012 Dec | Yang H | doi: 10.1007/s12029-012-9388-z. |
| 26421687 | The APC I1307K allele conveys a significant increased risk for cancer. | Int J Cancer | 2016 Mar 15 | Leshno A | doi: 10.1002/ijc.29876 |
| 24005794 | Ultrasensitive detection of unknown colon cancer-initiating mutations using the example of the Adenomatous polyposis coli gene. | Cancer Prev Res (Phila) | 2013 Sep | Gerecke C | doi: 10.1158/1940-6207.CAPR-13-0145. |
| 16184469 | Meat and fish consumption, APC gene mutations and hMLH1 expression in colon and rectal cancer: a prospective cohort study (The Netherlands). | Cancer Causes Control | 2005 Nov | L??chtenborg M | - |
| 23504555 | Analysis of the methylation patterns of the p16 INK4A, p15 INK4B, and APC genes in gastric adenocarcinoma patients from a Brazilian population. | Tumour Biol | 2013 Aug | do Nascimento Borges B | doi: 10.1007/s13277-013-0742-y |
| 22324744 | DNA alterations of microsatellite DNA, p53, APC and K-ras in Chinese colorectal cancer patients. | Eur J Clin Invest | 2012 Jul | Xu XM | doi: 10.1111/j.1365-2362.2011.02641.x |
| 12093899 | Mutations in APC, Kirsten-ras, and p53--alternative genetic pathways to colorectal cancer. | Proc Natl Acad Sci U S A | 2002 Jul 9 | Smith G | - |
| 11751382 | Evidence that APC regulates survivin expression: a possible mechanism contributing to the stem cell origin of colon cancer. | Cancer Res | 2001 Dec 15 | Zhang T | - |
| 23393221 | Regulation of APC and AXIN2 expression by intestinal tumor suppressor CDX2 in colon cancer cells. | Carcinogenesis | 2013 Jun | Olsen AK | doi: 10.1093/carcin/bgt037 |
| 25738352 | Correlation between the expression of DNMT1, and GSTP1 and APC, and the methylation status of GSTP1 and APC in association with their clinical significance in prostate cancer. | Mol Med Rep | 2015 Jul | Zhang W | doi: 10.3892/mmr.2015.3402 |
| 26970738 | Copy number of the Adenomatous Polyposis Coli gene is not always neutral in sporadic colorectal cancers with loss of heterozygosity for the gene. | BMC Cancer | 2016 Mar 12 | Zauber P | doi: 10.1186/s12885-016-2243-z. |
| 18632633 | Regulation of the adenomatous polyposis coli gene by the miR-135 family in colorectal cancer. | Cancer Res | 2008 Jul 15 | Nagel R | doi: 10.1158/0008-5472.CAN-08-0951. |
| 22509309 | A common role for various human truncated adenomatous polyposis coli isoforms in the control of beta-catenin activity and cell proliferation. | PLoS One | 2012 | Chandra SH | doi: 10.1371/journal.pone.0034479 |
| 15375803 | Colorectal cancer prevention. | Curr Probl Cancer | 2004 Sep-Oct | Kauh J | - |
| 19584833 | DNA promoter hypermethylation of p16 and APC predicts neoplastic progression in Barrett's esophagus. | Am J Gastroenterol | 2009 Sep | Wang JS | doi: 10.1038/ajg.2009.300 |
| 21857949 | Role of heterozygous APC mutation in niche succession and initiation of colorectal cancer--a computational study. | PLoS One | 2011 | Sasikumar R | doi: 10.1371/journal.pone.0022720 |
| 18369740 | Somatic APC inactivation mechanisms in sporadic colorectal cancer cases in Hungary. | Pathol Oncol Res | 2008 Mar | K??mory E | doi: 10.1007/s12253-008-9019-y |
| 12647217 | Expressions of two adenomatous polyposis coli and E-cadherin proteins on human colorectal cancers. | Virchows Arch | 2003 Mar | Furuta K | - |
| 17556698 | The D1822V APC polymorphism interacts with fat, calcium, and fiber intakes in modulating the risk of colorectal cancer in Portuguese persons. | Am J Clin Nutr | 2007 Jun | Guerreiro CS | - |
| 17119068 | APC E1317Q is not associated with Colorectal Cancer in a population-based case-control study in Northern Israel. | Cancer Epidemiol Biomarkers Prev | 2006 Nov | Rozek LS | - |
| 24496450 | Regulation of the phosphorylation and nuclear import and export of β-catenin by APC and its cancer-related truncated form. | J Cell Sci | 2014 Apr 15 | Wang L | doi: 10.1242/jcs.131045 |
| 18612690 | Missense polymorphisms in the adenomatous polyposis coli gene and colorectal cancer risk. | Dis Colon Rectum | 2008 Oct | Cleary SP | doi: 10.1007/s10350-008-9356-7 |
| 24320611 | Physiological expression of the PI3K-activating mutation Pik3ca(H1047R) combines with Apc loss to promote development of invasive intestinal adenocarcinomas in mice. | Biochem J | 2014 Mar 1 | Hare LM | doi: 10.1042/BJ20131412. |
| 27983523 | CpG methylation of APC promoter 1A in sporadic and familial breast cancer patients. | Cancer Biomark | 2017 | Debouki-Joudi S | doi: 10.3233/CBM-160005. |
| 17704924 | Genetic alterations of APC, K-ras, p53, MSI, and MAGE in Korean colorectal cancer patients. | Int J Colorectal Dis | 2008 Jan | Jeon CH | - |
| 23773491 | The prognostic significance of APC gene mutation and miR-21 expression in advanced-stage colorectal cancer. | Colorectal Dis | 2013 Nov | Chen TH | doi: 10.1111/codi.12318. |
| 25417611 | Promoter hypermethylation of p16 and APC in gastrointestinal cancer patients. | Turk J Gastroenterol | 2014 Oct | Erdem B | doi: 10.5152/tjg.2014.4791. |
| 21302450 | [Expressions of APC and c-Myc and its implication on non-small cell lung cancer]. | Sichuan Da Xue Xue Bao Yi Xue Ban | 2010 Sep | Wang SF | - |
| 26320184 | Adenomatous polyposis coli mutants dominantly activate Hsf1-dependent cell stress pathways through inhibition of microtubule dynamics. | Oncotarget | 2015 Sep 22 | Davies AE | doi: 10.18632/oncotarget.4513. |
| 18841156 | Aberrant methylation of the Adenomatous Polyposis Coli (APC) gene promoter is associated with the inflammatory breast cancer phenotype. | Br J Cancer | 2008 Nov 18 | Van der Auwera I | doi: 10.1038/sj.bjc.6604705 |
| 22277732 | Increased plasma levels of the APC-interacting protein MAPRE1, LRG1, and IGFBP2 preceding a diagnosis of colorectal cancer in women. | Cancer Prev Res (Phila) | 2012 Apr | Ladd JJ | doi: 10.1158/1940-6207.CAPR-11-0412 |
| 15943410 | APC, K-ras, and p53 gene mutations in colorectal cancer patients: correlation to clinicopathologic features and postoperative surveillance. | Am Surg | 2005 Apr | Hsieh JS | - |
| 15020226 | MUC1 can interact with adenomatous polyposis coli in breast cancer. | Biochem Biophys Res Commun | 2004 Apr 2 | Hattrup CL | - |
| 17854661 | How the I1307K adenomatous polyposis coli gene variant contributes in the assessment of risk of colorectal cancer, but not stomach cancer, in a Turkish population. | Cancer Genet Cytogenet | 2007 Sep | Dundar M | - |
| 21207416 | Association of tissue promoter methylation levels of APC, TGFβ2, HOXD3 and RASSF1A with prostate cancer progression. | Int J Cancer | 2011 Nov 15 | Liu L | doi: 10.1002/ijc.25908 |
| 20371677 | Long interspersed nuclear element 1 hypomethylation is a marker of poor prognosis in stage IA non-small cell lung cancer. | Clin Cancer Res | 2010 Apr 15 | Saito K | doi: 10.1158/1078-0432.CCR-09-2819 |
| 26314409 | Association of APC I1307K and E1317Q polymorphisms with colorectal cancer among Egyptian subjects. | Fam Cancer | 2016 Jan | Abdel-Malak C | doi: 10.1007/s10689-015-9834-8. |
| 25025473 | Mutations of C-reactive protein (CRP) -286 SNP, APC and p53 in colorectal cancer: implication for a CRP-Wnt crosstalk. | PLoS One | 2014 Jul 15 | Su HX | doi: 10.1371/journal.pone.0102418 |
| 25684670 | Aberrant methylation of APC and RARβ2 genes in breast cancer patients. | IUBMB Life | 2015 Jan | Swellam M | doi: 10.1002/iub.1346 |
| 12800196 | Epigenetic and genetic alterations of APC and CDH1 genes in lobular breast cancer: relationships with abnormal E-cadherin and catenin expression and microsatellite instability. | Int J Cancer | 2003 Aug 20 | Sarri?? D | - |
| 19777185 | Association analysis of Wnt pathway genes on prostate-specific antigen recurrence after radical prostatectomy. | Ann Surg Oncol | 2010 Jan | Huang SP | doi: 10.1245/s10434-009-0698-8 |
| 19470943 | Promoter methylation in APC, RUNX3, and GSTP1 and mortality in prostate cancer patients. | J Clin Oncol | 2009 Jul 1 | Richiardi L | doi: 10.1200/JCO.2008.18.2485 |
| 24078348 | An analysis of polymorphisms within the Wnt signaling pathway in relation to ovarian cancer risk in a Polish population. | Mol Diagn Ther | 2014 Feb | Mostowska A | - |
| 17562262 | [Methylation status and protein expression of adenomatous polyposis coli (APC) gene in breast cancer]. | Ai Zheng | 2007 Jun | Liu Z | - |
| 16450383 | Truncated APC is required for cell proliferation and DNA replication. | Int J Cancer | 2006 Jul 1 | Schneikert J | - |
| 24549056 | Attenuated familial adenomatous polyposis manifests as autosomal dominant late-onset colorectal cancer. | Eur J Hum Genet | 2014 Nov | Ibrahim A | doi: 10.1038/ejhg.2014.20 |
| 15548520 | Tumor suppressor APC blocks DNA polymerase beta-dependent strand displacement synthesis during long patch but not short patch base excision repair and increases sensitivity to methylmethane sulfonate. | J Biol Chem | 2005 Feb 25 | Narayan S | - |
| 24747657 | Clinical validation of an epigenetic assay to predict negative histopathological results in repeat prostate biopsies. | J Urol | 2014 Oct | Partin AW | doi: 10.1016/j.juro.2014.04.013 |
| 19945765 | DNA hypermethylation of tumors from non-small cell lung cancer (NSCLC) patients is associated with gender and histologic type. | Lung Cancer | 2010 Aug | Hawes SE | doi: 10.1016/j.lungcan.2009.11.002 |
| 17653897 | May the APC gene somatic mutations in tumor tissues influence the clinical features of Chinese sporadic colorectal cancers? | Acta Oncol | 2007 | Liu X | - |
| 22077694 | Evaluation of GSTP1 and APC methylation as indicators for repeat biopsy in a high-risk cohort of men with negative initial prostate biopsies. | BJU Int | 2012 Jul | Trock BJ | doi: 10.1111/j.1464-410X.2011.10718.x |
| 16710723 | The AAPC case, with an early onset of colorectal cancer. | Int J Colorectal Dis | 2007 Apr | Plawski A | - |
| 21279955 | Association of APC and MCC polymorphisms with increased breast cancer risk in an Indian population. | Int J Biol Markers | 2011 Jan-Mar | Mukherjee N | - |
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| 17960617 | Promoter hypermethylation in circulating blood cells identifies prostate cancer progression. | Int J Cancer | 2008 Feb 15 | Roupr??t M | - |
| 25210923 | The association between DNA copy number aberrations at chromosome 5q22 and gastric cancer. | PLoS One | 2014 Sep 11 | Tsai PC | doi: 10.1371/journal.pone.0106624 |
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| 15768050 | The tumor suppressor adenomatous polyposis coli gene is associated with susceptibility to schizophrenia. | Mol Psychiatry | 2005 Jul | Cui DH | - |
| 20056645 | Association of mitotic regulation pathway polymorphisms with pancreatic cancer risk and outcome. | Cancer Epidemiol Biomarkers Prev | 2010 Jan | Couch FJ | doi: 10.1158/1055-9965.EPI-09-0629. |
| 19515250 | A mitotic recombination map proximal to the APC locus on chromosome 5q and assessment of influences on colorectal cancer risk. | BMC Med Genet | 2009 Jun 10 | Howarth K | doi: 10.1186/1471-2350-10-54. |
| 19309276 | The association of methylation in the promoter of APC and MGMT and the prognosis of Taiwanese CRC patients. | Genet Test Mol Biomarkers | 2009 Feb | Chen SP | doi: 10.1089/gtmb.2008.0045. |
| 27595705 | miR-582-5P induces colorectal cancer cell proliferation by targeting adenomatous polyposis coli. | World J Surg Oncol | 2016 Sep 6 | Shu Z | doi: 10.1186/s12957-016-0984-4. |
| 27748282 | Epigenetic regulation of APC in the molecular pathogenesis of gallbladder cancer. | Indian J Med Res | 2016 May | Tekcham DS | doi: 10.4103/0971-5916.191792. |
| 27835699 | Gasdermin C Is Upregulated by Inactivation of Transforming Growth Factor β Receptor Type II in the Presence of Mutated Apc, Promoting Colorectal Cancer Proliferation. | PLoS One | 2016 Nov 11 | Miguchi M | doi: 10.1371/journal.pone.0166422 |
| 28179481 | APC Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer. | Mol Cancer Ther | 2017 Apr | Tanaka N | doi: 10.1158/1535-7163.MCT-16-0578 |
| 28164568 | Methylation Analysis of BRCA1 and APC in Breast Cancer and It's Relationship to Clinicopathological Features. | Clin Lab | 2016 Dec 1 | Shakeri H | doi: 10.7754/Clin.Lab.2016.160418. |
| 28497891 | Does adenomatous polyposis coli gene promoter 1A methylation increase non-small cell lung cancer risk? A meta-analysis. | Thorac Cancer | 2017 Sep | Hu B | doi: 10.1111/1759-7714.12450 |
| 28866416 | Upregulation of miR-3607 promotes lung adenocarcinoma proliferation by suppressing APC expression. | Biomed Pharmacother | 2017 Nov | Lin Y | doi: 10.1016/j.biopha.2017.08.052 |
| 29115417 | Wnt/β | Mol Med Rep | 2018 Jan | Ayala-Calvillo E | doi: 10.3892/mmr.2017.7853 |
| 29297603 | APC gene promoter aberrant methylation in serum as a biomarker for breast cancer diagnosis: A meta-analysis. | Thorac Cancer | 2018 Feb | Qian X | doi: 10.1111/1759-7714.12580 |
| 30376837 | APC gene is modulated by hsa-miR-135b-5p in both diffuse and intestinal gastric cancer subtypes. | BMC Cancer | 2018 Oct 30 | Magalh | doi: 10.1186/s12885-018-4980-7. |
| 30134915 | LINC01133 as ceRNA inhibits gastric cancer progression by sponging miR-106a-3p to regulate APC expression and the Wnt/β-catenin pathway. | Mol Cancer | 2018 Aug 22 | Yang XZ | doi: 10.1186/s12943-018-0874-1. |
| 30414835 | Role of adenomatous polyposis coli (APC) gene mutations in the pathogenesis of colorectal cancer; current status and perspectives. | Biochimie | 2019 Feb | Aghabozorgi AS | doi: 10.1016/j.biochi.2018.11.003 |
| Cancer | Chr | Position | Mutation Type | dbSNP | Protein-change | Allele Freq | RBD |
|---|---|---|---|---|---|---|---|
| ACC | chr5 | 112843222 | Missense_Mutation | novel | R2543K | 0.4 | |
| ACC | chr5 | 112767342 | Missense_Mutation | novel | N125S | 0.41 | |
| ACC | chr5 | 112839898 | Missense_Mutation | novel | R1435T | 0.26 | |
| BLCA | chr5 | 112842204 | Nonsense_Mutation | NA | R2204* | 0.15 | |
| BLCA | chr5 | 112841942 | Frame_Shift_Del | novel | Q2117Yfs*15 | 0.29 | |
| BLCA | chr5 | 112838026 | Missense_Mutation | novel | S811L | 0.72 | |
| BLCA | chr5 | 112838187 | Missense_Mutation | rs192620988 | P865S | 0.81 | |
| BLCA | chr5 | 112844062 | Missense_Mutation | novel | T2823R | 0.47 | |
| BLCA | chr5 | 112843979 | Silent | novel | A2795A | 0.24 | |
| BLCA | chr5 | 112841829 | Missense_Mutation | novel | D2079H | 0.22 | |
| BLCA | chr5 | 112819284 | Nonsense_Mutation | novel | E418* | 0.54 | |
| BLCA | chr5 | 112838544 | Nonsense_Mutation | NA | E984* | 0.82 | |
| BLCA | chr5 | 112838841 | Missense_Mutation | novel | D1083H | 0.7 | |
| BLCA | chr5 | 112842144 | Missense_Mutation | novel | E2184Q | 0.23 | |
| BLCA | chr5 | 112767374 | Missense_Mutation | novel | E136K | 0.06 | |
| BLCA | chr5 | 112837891 | Missense_Mutation | rs200339830 | A766V | 0.55 | |
| BLCA | chr5 | 112840693 | Missense_Mutation | novel | A1700V | 0.36 | |
| BLCA | chr5 | 112843079 | Silent | novel | T2495T | 0.46 | |
| BLCA | chr5 | 112843235 | Nonsense_Mutation | novel | W2547* | 0.08 | |
| BLCA | chr5 | 112838891 | Silent | novel | V1099V | 0.27 | |
| BLCA | chr5 | 112843140 | Missense_Mutation | novel | E2516Q | 0.38 | |
| BLCA | chr5 | 112841547 | Missense_Mutation | novel | E1985K | 0.2 | |
| BLCA | chr5 | 112840527 | Missense_Mutation | NA | E1645Q | 0.04 | |
| BLCA | chr5 | 112838521 | Missense_Mutation | novel | R976K | 0.4 | |
| BLCA | chr5 | 112839812 | Missense_Mutation | novel | Q1406H | 0.3 | |
| BLCA | chr5 | 112839060 | Nonsense_Mutation | NA | E1156* | 0.23 | |
| BLCA | chr5 | 112838855 | Silent | novel | L1087L | 0.11 | |
| BLCA | chr5 | 112843062 | Missense_Mutation | rs538230198 | D2490N | 0.12 | |
| BLCA | chr5 | 112838805 | Nonsense_Mutation | NA | Q1071* | 0.11 | |
| BLCA | chr5 | 112767291 | Missense_Mutation | novel | G108A | 0.4 | |
| BLCA | chr5 | 112767374 | Nonsense_Mutation | NA | E136* | 0.69 | |
| BLCA | chr5 | 112839477 | Missense_Mutation | novel | E1295K | 0.32 | |
| BLCA | chr5 | 112775709 | Missense_Mutation | NA | R168T | 0.32 | |
| BLCA | chr5 | 112840311 | Missense_Mutation | novel | E1573Q | 0.34 | |
| BRCA | chr5 | 112843346 | Frame_Shift_Del | NA | S2586Vfs*7 | 0.45 | |
| BRCA | chr5 | 112819013 | Frame_Shift_Del | NA | D328Mfs*8 | 0.8 | |
| BRCA | chr5 | 112843933 | Missense_Mutation | NA | R2780T | 0.12 | |
| BRCA | chr5 | 112840951 | Missense_Mutation | NA | R1786M | 0.49 | |
| BRCA | chr5 | 112841648 | Silent | NA | P2018P | 0.39 | |
| BRCA | chr5 | 112841405 | Silent | NA | S1937S | 0.19 | |
| BRCA | chr5 | 112839405 | Missense_Mutation | NA | F1271I | 0.18 | |
| BRCA | chr5 | 112819115 | Missense_Mutation | novel | H361Q | 0.05 | |
| BRCA | chr5 | 112842027 | Missense_Mutation | novel | G2145R | 0.07 | |
| BRCA | chr5 | 112843117 | Missense_Mutation | novel | P2508L | 0.07 | |
| BRCA | chr5 | 112839751 | Missense_Mutation | novel | R1386K | 0.26 | |
| BRCA | chr5 | 112843509 | Missense_Mutation | novel | E2639Q | 0.04 | |
| BRCA | chr5 | 112841586 | Missense_Mutation | NA | E1998K | 0.12 | |
| BRCA | chr5 | 112828932 | Missense_Mutation | NA | S568N | 0.54 | |
| BRCA | chr5 | 112844038 | Missense_Mutation | NA | K2815R | 0.1 | |
| BRCA | chr5 | 112837799 | Silent | rs141001261 | A735A | 0.59 | |
| BRCA | chr5 | 112840770 | Missense_Mutation | NA | E1726Q | 0.29 | |
| BRCA | chr5 | 112844043 | Missense_Mutation | NA | D2817H | 0.23 | |
| BRCA | chr5 | 112767293 | Nonsense_Mutation | NA | E109* | 0.1 | |
| BRCA | chr5 | 112819257 | Missense_Mutation | NA | L409I | 0.25 | |
| BRCA | chr5 | 112839691 | Missense_Mutation | NA | A1366V | 0.26 | |
| BRCA | chr5 | 112839793 | Missense_Mutation | rs267600319 | S1400L | 0.15 | |
| BRCA | chr5 | 112841009 | Missense_Mutation | NA | F1805L | 0.12 | |
| BRCA | chr5 | 112842262 | Nonsense_Mutation | NA | S2223* | 0.23 | |
| BRCA | chr5 | 112842889 | Missense_Mutation | novel | S2432L | 0.09 | |
| BRCA | chr5 | 112792447 | Missense_Mutation | rs76685252 | R216Q | 0.18 | |
| BRCA | chr5 | 112839387 | Missense_Mutation | NA | E1265Q | 0.34 | |
| BRCA | chr5 | 112839760 | Missense_Mutation | NA | S1389F | 0.29 | |
| BRCA | chr5 | 112843589 | Silent | NA | P2665P | 0.38 | |
| BRCA | chr5 | 112839344 | Missense_Mutation | NA | K1250N | 0.39 | |
| BRCA | chr5 | 112837979 | Silent | rs80188155 | L795L | 0.27 | |
| CESC | chr5 | 112792445 | Splice_Site | NA | X216_splice | 0.29 | |
| CESC | chr5 | 112841692 | Missense_Mutation | NA | D2033G | 0.24 | |
| CESC | chr5 | 112843654 | Missense_Mutation | rs144746572 | S2687L | 0.11 | |
| CESC | chr5 | 112839003 | Missense_Mutation | NA | D1137N | 0.39 | |
| CESC | chr5 | 112839003 | Missense_Mutation | NA | D1137H | 0.11 | |
| CESC | chr5 | 112815556 | Missense_Mutation | novel | S299C | 0.11 | |
| CESC | chr5 | 112827194 | Nonsense_Mutation | rs137854580 | R499* | 0.26 | |
| CESC | chr5 | 112837592 | Silent | novel | L666L | 0.41 | |
| CESC | chr5 | 112839247 | Missense_Mutation | rs377640390 | T1218M | 0.42 | |
| CESC | chr5 | 112839942 | Nonsense_Mutation | rs121913332 | R1450* | 0.41 | |
| CESC | chr5 | 112842321 | Missense_Mutation | rs773539706 | T2243A | 0.4 | |
| CESC | chr5 | 112842909 | Missense_Mutation | NA | R2439C | 0.43 | |
| CESC | chr5 | 112821958 | Missense_Mutation | novel | D459H | 0.12 | |
| CESC | chr5 | 112842458 | Silent | novel | Q2288Q | 0.32 | |
| CESC | chr5 | 112801278 | Splice_Site | NA | X244_splice | 0.26 | |
| CESC | chr5 | 112838346 | Missense_Mutation | novel | E918K | 0.31 | |
| CESC | chr5 | 112839039 | Missense_Mutation | rs371117193 | E1149K | 0.22 | |
| CESC | chr5 | 112840224 | Missense_Mutation | NA | E1544Q | 0.29 | |
| CHOL | chr5 | 112839833 | Frame_Shift_Del | NA | V1414* | 0.75 | |
| COAD | chr5 | 112839783 | Nonsense_Mutation | NA | E1397* | 0.58 | |
| COAD | chr5 | 112838571 | Nonsense_Mutation | NA | K993* | 0.43 | |
| COAD | chr5 | 112840057 | Frame_Shift_Del | novel | L1488Ffs*17 | 0.27 | |
| COAD | chr5 | 112839839 | Frame_Shift_Ins | novel | I1417Hfs*6 | 0.53 | |
| COAD | chr5 | 112827194 | Nonsense_Mutation | rs137854580 | R499* | 0.38 | |
| COAD | chr5 | 112839510 | Nonsense_Mutation | rs121913462 | E1306* | 0.38 | |
| COAD | chr5 | 112755025 | Frame_Shift_Ins | novel | E46Lfs*25 | 0.06 | |
| COAD | chr5 | 112837993 | Frame_Shift_Del | NA | F801Lfs*19 | 0.31 | |
| COAD | chr5 | 112840319 | Frame_Shift_Del | novel | E1576Kfs*74 | 0.61 | |
| COAD | chr5 | 112839496 | Frame_Shift_Del | NA | L1302Cfs*3 | 0.77 | |
| COAD | chr5 | 112839649 | Frame_Shift_Del | NA | E1353Nfs*62 | 0.5 | |
| COAD | chr5 | 112827248 | Splice_Site | novel | X516_splice | 0.24 | |
| COAD | chr5 | 112839883 | Frame_Shift_Del | NA | M1431Cfs*42 | 0.4 | |
| COAD | chr5 | 112839583 | Frame_Shift_Del | novel | P1330Qfs*11 | 0.22 | |
| COAD | chr5 | 112815564 | Nonsense_Mutation | rs137854568 | R302* | 0.35 | |
| COAD | chr5 | 112840254 | Frame_Shift_Ins | NA | T1556Nfs*3 | 0.38 | |
| COAD | chr5 | 112839726 | Nonsense_Mutation | rs121913329 | Q1378* | 0.85 | |
| COAD | chr5 | 112792446 | Nonsense_Mutation | rs62619935 | R216* | 0.51 | |
| COAD | chr5 | 112839693 | Nonsense_Mutation | rs121913328 | Q1367* | 0.7 | |
| COAD | chr5 | 112819112 | Frame_Shift_Del | novel | H361Wfs*3 | 0.6 | |
| COAD | chr5 | 112840254 | Frame_Shift_Ins | NA | T1556Nfs*3 | 0.74 | |
| COAD | chr5 | 112819238 | Frame_Shift_Del | NA | E403Kfs*51 | 0.39 | |
| COAD | chr5 | 112754895 | Missense_Mutation | NA | A2D | 0.41 | |
| COAD | chr5 | 112827972 | Missense_Mutation | NA | A531V | 0.3 | |
| COAD | chr5 | 112828919 | Nonsense_Mutation | rs137854574 | R564* | 0.3 | |
| COAD | chr5 | 112834968 | Silent | rs370783137 | S587S | 0.44 | |
| COAD | chr5 | 112839942 | Nonsense_Mutation | rs121913332 | R1450* | 0.39 | |
| COAD | chr5 | 112840580 | Silent | NA | I1662I | 0.45 | |
| COAD | chr5 | 112842880 | Missense_Mutation | NA | S2429F | 0.38 | |
| COAD | chr5 | 112839769 | Nonsense_Mutation | rs786204170 | S1392* | 0.38 | |
| COAD | chr5 | 112828899 | Missense_Mutation | NA | V557A | 0.19 | |
| COAD | chr5 | 112839855 | Frame_Shift_Del | NA | S1421Vfs*52 | 0.51 | |
| COAD | chr5 | 112801339 | Nonsense_Mutation | NA | Q264* | 0.31 | |
| COAD | chr5 | 112839924 | Nonsense_Mutation | NA | Q1444* | 0.4 | |
| COAD | chr5 | 112839952 | Frame_Shift_Ins | NA | K1454Lfs*20 | 0.81 | |
| COAD | chr5 | 112838415 | Nonsense_Mutation | NA | E941* | 0.24 | |
| COAD | chr5 | 112839899 | Frame_Shift_Ins | NA | S1436Rfs*38 | 0.42 | |
| COAD | chr5 | 112827194 | Nonsense_Mutation | rs137854580 | R499* | 0.42 | |
| COAD | chr5 | 112839945 | Nonsense_Mutation | NA | E1451* | 0.34 | |
| COAD | chr5 | 112815564 | Nonsense_Mutation | rs137854568 | R302* | 0.37 | |
| COAD | chr5 | 112839501 | Nonsense_Mutation | NA | Q1303* | 0.12 | |
| COAD | chr5 | 112819026 | Nonsense_Mutation | rs775126020 | R332* | 0.9 | |
| COAD | chr5 | 112840239 | Nonsense_Mutation | NA | Q1549* | 0.87 | |
| COAD | chr5 | 112843803 | Missense_Mutation | novel | E2737Q | 0.43 | |
| COAD | chr5 | 112839812 | Frame_Shift_Del | NA | S1407Vfs*8 | 0.39 | |
| COAD | chr5 | 112827132 | Frame_Shift_Ins | NA | L479Ifs*6 | 0.45 | |
| COAD | chr5 | 112839529 | Frame_Shift_Ins | NA | T1313Nfs*2 | 0.51 | |
| COAD | chr5 | 112839924 | Nonsense_Mutation | NA | Q1444* | 0.63 | |
| COAD | chr5 | 112839942 | Nonsense_Mutation | rs121913332 | R1450* | 0.44 | |
| COAD | chr5 | 112839208 | Frame_Shift_Del | novel | S1205Tfs*60 | 0.36 | |
| COAD | chr5 | 112839726 | Nonsense_Mutation | rs121913329 | Q1378* | 0.7 | |
| COAD | chr5 | 112839465 | Nonsense_Mutation | NA | Q1291* | 0.26 | |
| COAD | chr5 | 112838399 | Nonsense_Mutation | rs137854575 | Y935* | 0.45 | |
| COAD | chr5 | 112839942 | Nonsense_Mutation | rs121913332 | R1450* | 0.28 | |
| COAD | chr5 | 112766334 | Frame_Shift_Ins | NA | Q50Tfs*7 | 0.18 | |
| COAD | chr5 | 112838220 | Nonsense_Mutation | rs121913333 | R876* | 0.68 | |
| COAD | chr5 | 112840254 | Frame_Shift_Ins | NA | T1556Nfs*3 | 0.79 | |
| COAD | chr5 | 112838697 | Nonsense_Mutation | NA | Q1035* | 0.4 | |
| COAD | chr5 | 112839504 | Frame_Shift_Ins | novel | A1305Sfs*10 | 0.24 | |
| COAD | chr5 | 112827194 | Nonsense_Mutation | rs137854580 | R499* | 0.31 | |
| COAD | chr5 | 112827194 | Nonsense_Mutation | rs137854580 | R499* | 0.19 | |
| COAD | chr5 | 112840069 | Frame_Shift_Del | NA | T1493Rfs*14 | 0.49 | |
| COAD | chr5 | 112828919 | Nonsense_Mutation | rs137854574 | R564* | 0.27 | |
| COAD | chr5 | 112840333 | Frame_Shift_Del | novel | S1581Lfs*69 | 0.34 | |
| COAD | chr5 | 112839604 | Frame_Shift_Del | NA | L1337Pfs*4 | 0.82 | |
| COAD | chr5 | 112842240 | Missense_Mutation | novel | P2216S | 0.15 | |
| COAD | chr5 | 112801351 | Nonsense_Mutation | novel | E268* | 0.83 | |
| COAD | chr5 | 112839324 | Nonsense_Mutation | NA | Q1244* | 0.64 | |
| COAD | chr5 | 112839219 | Nonsense_Mutation | NA | E1209* | 0.35 | |
| COAD | chr5 | 112839082 | Frame_Shift_Del | NA | S1163Tfs*2 | 0.41 | |
| COAD | chr5 | 112840312 | Frame_Shift_Del | NA | I1574Yfs*2 | 0.36 | |
| COAD | chr5 | 112815507 | Nonsense_Mutation | rs786201856 | R283* | 0.26 | |
| COAD | chr5 | 112839519 | Nonsense_Mutation | NA | E1309* | 0.21 | |
| COAD | chr5 | 112838934 | Nonsense_Mutation | rs121913331 | R1114* | 0.41 | |
| COAD | chr5 | 112839899 | Frame_Shift_Del | NA | S1436Vfs*37 | 0.37 | |
| COAD | chr5 | 112775711 | Frame_Shift_Del | novel | D170Vfs*4 | 0.3 | |
| COAD | chr5 | 112839436 | Nonsense_Mutation | NA | S1281* | 0.41 | |
| COAD | chr5 | 112839538 | Nonsense_Mutation | NA | S1315* | 0.88 | |
| COAD | chr5 | 112837586 | Silent | novel | T664T | 0.3 | |
| COAD | chr5 | 112838934 | Nonsense_Mutation | rs121913331 | R1114* | 0.26 | |
| COAD | chr5 | 112842303 | Nonsense_Mutation | rs768922431 | R2237* | 0.22 | |
| COAD | chr5 | 112843945 | Missense_Mutation | novel | F2784C | 0.28 | |
| COAD | chr5 | 112838769 | Nonsense_Mutation | NA | E1059* | 0.2 | |
| COAD | chr5 | 112792446 | Nonsense_Mutation | rs62619935 | R216* | 0.52 | |
| COAD | chr5 | 112842672 | Missense_Mutation | novel | G2360S | 0.52 | |
| COAD | chr5 | 112828889 | Nonsense_Mutation | rs137854573 | R554* | 0.28 | |
| COAD | chr5 | 112775652 | Missense_Mutation | novel | D149G | 0.1 | |
| COAD | chr5 | 112839519 | Nonsense_Mutation | NA | E1309* | 0.26 | |
| COAD | chr5 | 112841680 | Missense_Mutation | novel | S2029Y | 0.24 | |
| COAD | chr5 | 112837702 | Missense_Mutation | novel | A703E | 0.34 | |
| COAD | chr5 | 112838361 | Nonsense_Mutation | NA | R923* | 0.25 | |
| COAD | chr5 | 112839942 | Nonsense_Mutation | rs121913332 | R1450* | 0.38 | |
| COAD | chr5 | 112792494 | Nonsense_Mutation | rs397515734 | R232* | 0.18 | |
| COAD | chr5 | 112835080 | Frame_Shift_Del | NA | N627Lfs*2 | 0.45 | |
| COAD | chr5 | 112839403 | Frame_Shift_Ins | novel | S1272Ffs*4 | 0.15 | |
| COAD | chr5 | 112840051 | Frame_Shift_Del | novel | T1487Yfs*18 | 0.1 | |
| COAD | chr5 | 112840059 | Frame_Shift_Ins | novel | H1490Nfs*25 | 0.21 | |
| COAD | chr5 | 112780895 | Nonsense_Mutation | rs587781392 | R213* | 0.33 | |
| COAD | chr5 | 112839783 | Nonsense_Mutation | NA | E1397* | 0.44 | |
| COAD | chr5 | 112780895 | Nonsense_Mutation | rs587781392 | R213* | 0.25 | |
| COAD | chr5 | 112839879 | Nonsense_Mutation | rs74535574 | Q1429* | 0.29 | |
| COAD | chr5 | 112819037 | Silent | rs3797704 | L335L | 0.26 | |
| COAD | chr5 | 112841617 | Missense_Mutation | novel | A2008V | 0.17 | |
| COAD | chr5 | 112815531 | Frame_Shift_Ins | NA | L292Ffs*4 | 0.26 | |
| COAD | chr5 | 112828967 | Frame_Shift_Del | NA | K581Rfs*9 | 0.38 | |
| COAD | chr5 | 112835125 | Missense_Mutation | NA | R640W | 0.37 | |
| COAD | chr5 | 112838220 | Nonsense_Mutation | rs121913333 | R876* | 0.35 | |
| COAD | chr5 | 112839942 | Nonsense_Mutation | rs121913332 | R1450* | 0.47 | |
| COAD | chr5 | 112840330 | Frame_Shift_Del | NA | I1580Lfs*69 | 0.59 | |
| COAD | chr5 | 112838600 | Silent | rs72541810 | A1002A | 0.52 | |
| COAD | chr5 | 112838934 | Nonsense_Mutation | rs121913331 | R1114* | 0.23 | |
| COAD | chr5 | 112840254 | Frame_Shift_Ins | NA | T1556Nfs*3 | 0.3 | |
| COAD | chr5 | 112838483 | Frame_Shift_Del | NA | L964* | 0.44 | |
| COAD | chr5 | 112839856 | Frame_Shift_Del | NA | S1421Mfs*52 | 0.67 | |
| COAD | chr5 | 112838220 | Nonsense_Mutation | rs121913333 | R876* | 0.34 | |
| COAD | chr5 | 112840331 | Frame_Shift_Ins | NA | I1580Nfs*11 | 0.36 | |
| COAD | chr5 | 112815579 | Frame_Shift_Del | NA | H307Ifs*29 | 0.68 | |
| COAD | chr5 | 112839787 | Frame_Shift_Del | NA | S1398Ifs*17 | 0.86 | |
| COAD | chr5 | 112780895 | Nonsense_Mutation | rs587781392 | R213* | 0.76 | |
| COAD | chr5 | 112839799 | Frame_Shift_Del | novel | S1403Mfs*13 | 0.05 | |
| COAD | chr5 | 112835166 | Splice_Site | NA | X653_splice | 0.2 | |
| COAD | chr5 | 112839978 | Frame_Shift_Ins | NA | S1465Rfs*9 | 0.38 | |
| COAD | chr5 | 112828889 | Nonsense_Mutation | rs137854573 | R554* | 0.43 | |
| COAD | chr5 | 112839942 | Nonsense_Mutation | rs121913332 | R1450* | 0.35 | |
| COAD | chr5 | 112840023 | Nonsense_Mutation | NA | Q1477* | 0.57 | |
| COAD | chr5 | 112838007 | Nonsense_Mutation | rs587779783 | R805* | 0.38 | |
| COAD | chr5 | 112840055 | Frame_Shift_Del | NA | L1488Yfs*19 | 0.4 | |
| COAD | chr5 | 112839796 | Frame_Shift_Del | NA | I1401Mfs*14 | 0.73 | |
| COAD | chr5 | 112819236 | Missense_Mutation | NA | R402C | 0.26 | |
| COAD | chr5 | 112839654 | Frame_Shift_Del | NA | S1355Lfs*60 | 0.53 | |
| COAD | chr5 | 112835065 | Frame_Shift_Del | novel | Y622Gfs*7 | 0.38 | |
| COAD | chr5 | 112839673 | Missense_Mutation | novel | S1360C | 0.36 | |
| COAD | chr5 | 112780895 | Nonsense_Mutation | rs587781392 | R213* | 0.57 | |
| COAD | chr5 | 112839625 | Nonsense_Mutation | NA | S1344* | 0.19 | |
| COAD | chr5 | 112839465 | Nonsense_Mutation | NA | Q1291* | 0.5 | |
| COAD | chr5 | 112792446 | Nonsense_Mutation | rs62619935 | R216* | 0.67 | |
| COAD | chr5 | 112815507 | Nonsense_Mutation | rs786201856 | R283* | 0.41 | |
| COAD | chr5 | 112838134 | Frame_Shift_Del | NA | D849Ifs*12 | 0.47 | |
| COAD | chr5 | 112839644 | Frame_Shift_Ins | NA | A1351Gfs*3 | 0.81 | |
| COAD | chr5 | 112839210 | Missense_Mutation | NA | S1206G | 0.21 | |
| COAD | chr5 | 112838934 | Nonsense_Mutation | rs121913331 | R1114* | 0.53 | |
| COAD | chr5 | 112839875 | Frame_Shift_Ins | NA | Q1429Dfs*45 | 0.42 | |
| COAD | chr5 | 112839574 | Nonsense_Mutation | NA | S1327* | 0.35 | |
| COAD | chr5 | 112838778 | Nonsense_Mutation | NA | Q1062* | 0.28 | |
| COAD | chr5 | 112840059 | Frame_Shift_Del | NA | L1489Yfs*18 | 0.26 | |
| COAD | chr5 | 112780895 | Nonsense_Mutation | rs587781392 | R213* | 0.47 | |
| COAD | chr5 | 112838422 | Nonsense_Mutation | NA | S943* | 0.13 | |
| COAD | chr5 | 112839833 | Frame_Shift_Del | NA | V1414* | 0.73 | |
| COAD | chr5 | 112838934 | Nonsense_Mutation | rs121913331 | R1114* | 0.24 | |
| COAD | chr5 | 112840059 | Frame_Shift_Del | NA | L1489Yfs*18 | 0.26 | |
| COAD | chr5 | 112839474 | Nonsense_Mutation | NA | Q1294* | 0.76 | |
| COAD | chr5 | 112780814 | Nonsense_Mutation | novel | R186* | 0.55 | |
| COAD | chr5 | 112839585 | Nonsense_Mutation | NA | R1331* | 0.36 | |
| COAD | chr5 | 112835166 | Splice_Site | NA | X653_splice | 0.36 | |
| COAD | chr5 | 112839942 | Nonsense_Mutation | rs121913332 | R1450* | 0.3 | |
| COAD | chr5 | 112840254 | Frame_Shift_Ins | NA | T1556Nfs*3 | 0.76 | |
| COAD | chr5 | 112840049 | Frame_Shift_Del | NA | D1486Ifs*21 | 0.84 | |
| COAD | chr5 | 112792489 | Missense_Mutation | rs587780545 | R230H | 0.34 | |
| COAD | chr5 | 112838220 | Nonsense_Mutation | rs121913333 | R876* | 0.43 | |
| COAD | chr5 | 112839833 | Frame_Shift_Del | NA | V1414* | 0.35 | |
| COAD | chr5 | 112827194 | Nonsense_Mutation | rs137854580 | R499* | 0.46 | |
| COAD | chr5 | 112839294 | Missense_Mutation | novel | S1234G | 0.39 | |
| COAD | chr5 | 112840254 | Frame_Shift_Ins | NA | T1556Nfs*3 | 0.46 | |
| COAD | chr5 | 112837903 | Nonsense_Mutation | novel | S770* | 0.37 | |
| COAD | chr5 | 112840186 | Frame_Shift_Del | novel | N1531Rfs*31 | 0.18 | |
| COAD | chr5 | 112838473 | Frame_Shift_Ins | NA | N961Kfs*5 | 0.45 | |
| COAD | chr5 | 112839827 | Frame_Shift_Del | NA | S1411Rfs*4 | 0.42 | |
| COAD | chr5 | 112780895 | Nonsense_Mutation | rs587781392 | R213* | 0.42 | |
| COAD | chr5 | 112839549 | Frame_Shift_Del | NA | P1319Lfs*2 | 0.37 | |
| COAD | chr5 | 112839951 | Frame_Shift_Del | NA | P1453Lfs*20 | 0.16 | |
| COAD | chr5 | 112839701 | Silent | NA | P1369P | 0.63 | |
| COAD | chr5 | 112839942 | Nonsense_Mutation | rs121913332 | R1450* | 0.71 | |
| COAD | chr5 | 112838220 | Nonsense_Mutation | rs121913333 | R876* | 0.35 | |
| COAD | chr5 | 112839714 | Nonsense_Mutation | NA | E1374* | 0.34 | |
| COAD | chr5 | 112838420 | Frame_Shift_Del | NA | S943Qfs*12 | 0.23 | |
| COAD | chr5 | 112839896 | Frame_Shift_Del | NA | R1435Lfs*31 | 0.38 | |
| COAD | chr5 | 112815564 | Nonsense_Mutation | rs137854568 | R302* | 0.31 | |
| COAD | chr5 | 112828007 | Splice_Site | novel | X542_splice | 0.18 | |
| COAD | chr5 | 112839942 | Nonsense_Mutation | rs121913332 | R1450* | 0.2 | |
| COAD | chr5 | 112838934 | Nonsense_Mutation | rs121913331 | R1114* | 0.49 | |
| COAD | chr5 | 112838220 | Nonsense_Mutation | rs121913333 | R876* | 0.44 | |
| COAD | chr5 | 112839942 | Nonsense_Mutation | rs121913332 | R1450* | 0.08 | |
| COAD | chr5 | 112792515 | Frame_Shift_Del | novel | A239Qfs*54 | 0.25 | |
| COAD | chr5 | 112838934 | Nonsense_Mutation | rs121913331 | R1114* | 0.43 | |
| COAD | chr5 | 112837691 | Nonsense_Mutation | NA | W699* | 0.79 | |
| COAD | chr5 | 112780895 | Nonsense_Mutation | rs587781392 | R213* | 0.61 | |
| COAD | chr5 | 112780828 | Frame_Shift_Ins | NA | Y191Lfs*2 | 0.38 | |
| COAD | chr5 | 112839474 | Nonsense_Mutation | NA | Q1294* | 0.31 | |
| COAD | chr5 | 112792446 | Nonsense_Mutation | rs62619935 | R216* | 0.43 | |
| COAD | chr5 | 112839726 | Nonsense_Mutation | rs121913329 | Q1378* | 0.36 | |
| COAD | chr5 | 112839714 | Nonsense_Mutation | NA | E1374* | 0.89 | |
| COAD | chr5 | 112838007 | Nonsense_Mutation | rs587779783 | R805* | 0.19 | |
| COAD | chr5 | 112838364 | Nonsense_Mutation | NA | R924* | 0.21 | |
| COAD | chr5 | 112839942 | Nonsense_Mutation | rs121913332 | R1450* | 0.45 | |
| COAD | chr5 | 112827137 | Nonsense_Mutation | NA | Q480* | 0.47 | |
| COAD | chr5 | 112840055 | Frame_Shift_Del | NA | L1488Yfs*19 | 0.43 | |
| COAD | chr5 | 112840049 | Frame_Shift_Del | NA | D1486Ifs*21 | 0.67 | |
| COAD | chr5 | 112827947 | Nonsense_Mutation | novel | K523* | 0.24 | |
| COAD | chr5 | 112839979 | Frame_Shift_Del | NA | E1464Vfs*8 | 0.22 | |
| COAD | chr5 | 112819266 | Nonsense_Mutation | NA | Q412* | 0.46 | |
| COAD | chr5 | 112840091 | Frame_Shift_Ins | NA | S1501Ffs*13 | 0.5 | |
| COAD | chr5 | 112840707 | Missense_Mutation | NA | T1705P | 0.23 | |
| COAD | chr5 | 112838134 | Frame_Shift_Del | NA | D849Ifs*12 | 0.58 | |
| COAD | chr5 | 112819301 | Nonsense_Mutation | novel | W423* | 0.42 | |
| COAD | chr5 | 112839653 | Frame_Shift_Ins | NA | S1355Ffs*62 | 0.37 | |
| COAD | chr5 | 112838399 | Nonsense_Mutation | rs137854575 | Y935* | 0.4 | |
| COAD | chr5 | 112839933 | Nonsense_Mutation | NA | Q1447* | 0.25 | |
| COAD | chr5 | 112839978 | Frame_Shift_Ins | NA | S1465Rfs*9 | 0.3 | |
| COAD | chr5 | 112839469 | Missense_Mutation | rs371113837 | T1292M | 0.49 | |
| COAD | chr5 | 112780895 | Nonsense_Mutation | rs587781392 | R213* | 0.16 | |
| COAD | chr5 | 112839942 | Nonsense_Mutation | rs121913332 | R1450* | 0.2 | |
| COAD | chr5 | 112780895 | Nonsense_Mutation | rs587781392 | R213* | 0.12 | |
| COAD | chr5 | 112839556 | Frame_Shift_Ins | novel | E1322Rfs*10 | 0.15 | |
| COAD | chr5 | 112839558 | Missense_Mutation | novel | E1322Q | 0.15 | |
| COAD | chr5 | 112835083 | Frame_Shift_Del | novel | N627Lfs*2 | 0.66 | |
| COAD | chr5 | 112827999 | Frame_Shift_Ins | novel | Q541Tfs*19 | 0.63 | |
| COAD | chr5 | 112780895 | Nonsense_Mutation | rs587781392 | R213* | 0.36 | |
| COAD | chr5 | 112828919 | Nonsense_Mutation | rs137854574 | R564* | 0.75 | |
| COAD | chr5 | 112839478 | Frame_Shift_Del | NA | A1296Qfs*9 | 0.88 | |
| COAD | chr5 | 112839942 | Nonsense_Mutation | rs121913332 | R1450* | 0.68 | |
| COAD | chr5 | 112780788 | Splice_Site | novel | X178_splice | 0.2 | |
| COAD | chr5 | 112838697 | Nonsense_Mutation | NA | Q1035* | 0.31 | |
| COAD | chr5 | 112819074 | Nonsense_Mutation | NA | R348* | 0.34 | |
| COAD | chr5 | 112828919 | Nonsense_Mutation | rs137854574 | R564* | 0.35 | |
| COAD | chr5 | 112838220 | Nonsense_Mutation | rs121913333 | R876* | 0.28 | |
| COAD | chr5 | 112839942 | Nonsense_Mutation | rs121913332 | R1450* | 0.28 | |
| COAD | chr5 | 112838399 | Nonsense_Mutation | rs137854575 | Y935* | 0.27 | |
| COAD | chr5 | 112792494 | Nonsense_Mutation | rs397515734 | R232* | 0.77 | |
| COAD | chr5 | 112815507 | Nonsense_Mutation | rs786201856 | R283* | 0.47 | |
| COAD | chr5 | 112839726 | Nonsense_Mutation | rs121913329 | Q1378* | 0.57 | |
| COAD | chr5 | 112775705 | Frame_Shift_Del | novel | R168Efs*2 | 0.45 | |
| COAD | chr5 | 112839757 | Frame_Shift_Ins | novel | V1390Ffs*6 | 0.39 | |
| COAD | chr5 | 112839163 | Frame_Shift_Del | novel | S1190Yfs*75 | 0.47 | |
| COAD | chr5 | 112838415 | Nonsense_Mutation | NA | E941* | 0.24 | |
| COAD | chr5 | 112840059 | Frame_Shift_Ins | novel | H1490Yfs*18 | 0.48 | |
| COAD | chr5 | 112839979 | Frame_Shift_Del | NA | E1464Vfs*8 | 0.32 | |
| COAD | chr5 | 112837863 | Frame_Shift_Ins | novel | A759Sfs*16 | 0.2 | |
| COAD | chr5 | 112839942 | Nonsense_Mutation | rs121913332 | R1450* | 0.26 | |
| COAD | chr5 | 112838397 | Nonsense_Mutation | NA | Y935* | 0.42 | |
| COAD | chr5 | 112839654 | Frame_Shift_Del | NA | S1355Lfs*60 | 0.67 | |
| COAD | chr5 | 112839474 | Nonsense_Mutation | NA | Q1294* | 0.24 | |
| COAD | chr5 | 112819245 | Nonsense_Mutation | rs587779780 | R405* | 0.37 | |
| COAD | chr5 | 112840262 | Frame_Shift_Del | novel | I1557* | 0.43 | |
| COAD | chr5 | 112838715 | Nonsense_Mutation | NA | Q1041* | 0.65 | |
| COAD | chr5 | 112838220 | Nonsense_Mutation | rs121913333 | R876* | 0.66 | |
| COAD | chr5 | 112840323 | Frame_Shift_Ins | novel | C1578Mfs*13 | 0.68 | |
| COAD | chr5 | 112837921 | Frame_Shift_Del | novel | D777Kfs*8 | 0.3 | |
| COAD | chr5 | 112839833 | Frame_Shift_Del | NA | V1414* | 0.18 | |
| COAD | chr5 | 112819345 | Splice_Site | NA | X438_splice | 0.89 | |
| COAD | chr5 | 112839942 | Nonsense_Mutation | rs121913332 | R1450* | 0.51 | |
| COAD | chr5 | 112839726 | Nonsense_Mutation | rs121913329 | Q1378* | 0.76 | |
| COAD | chr5 | 112838220 | Nonsense_Mutation | rs121913333 | R876* | 0.14 | |
| COAD | chr5 | 112839954 | Frame_Shift_Del | NA | N1455Ifs*18 | 0.15 | |
| COAD | chr5 | 112792446 | Nonsense_Mutation | rs62619935 | R216* | 0.8 | |
| COAD | chr5 | 112839918 | Frame_Shift_Del | NA | P1442Lfs*31 | 0.41 | |
| COAD | chr5 | 112838007 | Nonsense_Mutation | rs587779783 | R805* | 0.4 | |
| COAD | chr5 | 112840194 | Frame_Shift_Del | novel | N1535Mfs*30 | 0.28 | |
| COAD | chr5 | 112838399 | Nonsense_Mutation | rs137854575 | Y935* | 0.21 | |
| COAD | chr5 | 112839879 | Nonsense_Mutation | rs74535574 | Q1429* | 0.53 | |
| COAD | chr5 | 112838290 | Frame_Shift_Del | NA | T899Ifs*12 | 0.4 | |
| COAD | chr5 | 112792445 | Splice_Site | NA | X216_splice | 0.15 | |
| COAD | chr5 | 112838751 | Frame_Shift_Del | novel | K1053Nfs*3 | 0.39 | |
| COAD | chr5 | 112839999 | Nonsense_Mutation | NA | Q1469* | 0.78 | |
| COAD | chr5 | 112840255 | Frame_Shift_Del | NA | T1556Lfs*9 | 0.61 | |
| COAD | chr5 | 112819026 | Nonsense_Mutation | rs775126020 | R332* | 0.61 | |
| COAD | chr5 | 112839627 | Nonsense_Mutation | NA | E1345* | 0.55 | |
| COAD | chr5 | 112838420 | Frame_Shift_Del | NA | S943Qfs*12 | 0.33 | |
| COAD | chr5 | 112839810 | Nonsense_Mutation | rs587782518 | Q1406* | 0.21 | |
| COAD | chr5 | 112838914 | Missense_Mutation | NA | A1107V | 0.16 | |
| COAD | chr5 | 112801278 | Splice_Site | NA | X244_splice | 0.26 | |
| COAD | chr5 | 112839931 | Frame_Shift_Del | novel | Q1447Sfs*24 | 0.77 | |
| COAD | chr5 | 112834969 | Missense_Mutation | rs372416031 | V588I | 0.15 | |
| COAD | chr5 | 112828004 | Nonsense_Mutation | NA | Q542* | 0.21 | |
| COAD | chr5 | 112838300 | Frame_Shift_Ins | novel | D903Sfs*2 | 0.4 | |
| COAD | chr5 | 112838346 | Nonsense_Mutation | NA | E918* | 0.4 | |
| COAD | chr5 | 112840058 | Frame_Shift_Del | NA | L1489Kfs*19 | 0.34 | |
| COAD | chr5 | 112838397 | Nonsense_Mutation | NA | Y935* | 0.22 | |
| COAD | chr5 | 112840064 | Frame_Shift_Del | NA | F1491Lfs*16 | 0.27 | |
| COAD | chr5 | 112839558 | Nonsense_Mutation | NA | E1322* | 0.6 | |
| COAD | chr5 | 112839816 | Nonsense_Mutation | NA | E1408* | 0.85 | |
| COAD | chr5 | 112838220 | Nonsense_Mutation | rs121913333 | R876* | 0.36 | |
| COAD | chr5 | 112840247 | Frame_Shift_Del | NA | E1552Qfs*12 | 0.31 | |
| COAD | chr5 | 112792446 | Nonsense_Mutation | rs62619935 | R216* | 0.42 | |
| COAD | chr5 | 112792446 | Nonsense_Mutation | rs62619935 | R216* | 0.29 | |
| COAD | chr5 | 112838526 | Nonsense_Mutation | NA | Q978* | 0.24 | |
| COAD | chr5 | 112839702 | Nonsense_Mutation | NA | K1370* | 0.43 | |
| COAD | chr5 | 112839340 | Frame_Shift_Del | novel | C1249Sfs*16 | 0.59 | |
| COAD | chr5 | 112792467 | Nonsense_Mutation | novel | Q223* | 0.21 | |
| COAD | chr5 | 112839942 | Nonsense_Mutation | rs121913332 | R1450* | 0.52 | |
| COAD | chr5 | 112838220 | Nonsense_Mutation | rs121913333 | R876* | 0.51 | |
| COAD | chr5 | 112838942 | Silent | NA | G1116G | 0.48 | |
| COAD | chr5 | 112839519 | Nonsense_Mutation | NA | E1309* | 0.24 | |
| COAD | chr5 | 112827194 | Nonsense_Mutation | rs137854580 | R499* | 0.81 | |
| COAD | chr5 | 112815564 | Nonsense_Mutation | rs137854568 | R302* | 0.42 | |
| COAD | chr5 | 112839538 | Nonsense_Mutation | NA | S1315* | 0.86 | |
| COAD | chr5 | 112842303 | Nonsense_Mutation | rs768922431 | R2237* | 0.31 | |
| COAD | chr5 | 112838007 | Nonsense_Mutation | rs587779783 | R805* | 0.38 | |
| COAD | chr5 | 112839714 | Nonsense_Mutation | NA | E1374* | 0.41 | |
| COAD | chr5 | 112839726 | Nonsense_Mutation | rs121913329 | Q1378* | 0.66 | |
| COAD | chr5 | 112839452 | Frame_Shift_Ins | NA | G1288* | 0.58 | |
| COAD | chr5 | 112838095 | Missense_Mutation | novel | S834F | 0.84 | |
| COAD | chr5 | 112838100 | Frame_Shift_Del | novel | S836Lfs*3 | 0.82 | |
| COAD | chr5 | 112837819 | Frame_Shift_Del | novel | M743Cfs*18 | 0.29 | |
| COAD | chr5 | 112827194 | Nonsense_Mutation | rs137854580 | R499* | 0.17 | |
| COAD | chr5 | 112839990 | Nonsense_Mutation | NA | G1466* | 0.2 | |
| COAD | chr5 | 112821978 | Silent | NA | A465A | 0.3 | |
| COAD | chr5 | 112838934 | Nonsense_Mutation | rs121913331 | R1114* | 0.65 | |
| COAD | chr5 | 112828889 | Nonsense_Mutation | rs137854573 | R554* | 0.31 | |
| COAD | chr5 | 112837679 | Missense_Mutation | novel | Q695H | 0.15 | |
| COAD | chr5 | 112843240 | Missense_Mutation | rs199558585 | R2549H | 0.09 | |
| COAD | chr5 | 112839240 | Nonsense_Mutation | NA | E1216* | 0.42 | |
| COAD | chr5 | 112839999 | Nonsense_Mutation | NA | Q1469* | 0.24 | |
| COAD | chr5 | 112840073 | Frame_Shift_Del | NA | E1494Kfs*13 | 0.84 | |
| COAD | chr5 | 112840074 | Missense_Mutation | NA | E1494K | 0.84 | |
| COAD | chr5 | 112839784 | Frame_Shift_Del | NA | E1397Gfs*18 | 0.76 | |
| COAD | chr5 | 112839524 | Frame_Shift_Del | NA | I1311Lfs*10 | 0.45 | |
| COAD | chr5 | 112780895 | Nonsense_Mutation | rs587781392 | R213* | 0.31 | |
| COAD | chr5 | 112839511 | Frame_Shift_Del | novel | I1307Rfs*6 | 0.12 | |
| COAD | chr5 | 112839444 | Nonsense_Mutation | NA | E1284* | 0.34 | |
| COAD | chr5 | 112840182 | Nonsense_Mutation | NA | E1530* | 0.37 | |
| COAD | chr5 | 112838544 | Nonsense_Mutation | NA | E984* | 0.13 | |
| COAD | chr5 | 112839978 | Frame_Shift_Ins | NA | S1465Rfs*9 | 0.24 | |
| COAD | chr5 | 112838295 | Nonsense_Mutation | NA | Q901* | 0.41 | |
| COAD | chr5 | 112839833 | Frame_Shift_Del | NA | V1414* | 0.39 | |
| COAD | chr5 | 112839547 | Frame_Shift_Ins | novel | P1319Lfs*3 | 0.27 | |
| COAD | chr5 | 112838346 | Nonsense_Mutation | NA | E918* | 0.19 | |
| COAD | chr5 | 112839549 | Frame_Shift_Del | NA | P1319Lfs*2 | 0.26 | |
| COAD | chr5 | 112840189 | Missense_Mutation | novel | D1532G | 0.16 | |
| COAD | chr5 | 112838544 | Nonsense_Mutation | NA | E984* | 0.17 | |
| COAD | chr5 | 112840075 | Frame_Shift_Ins | novel | T1496Kfs*19 | 0.17 | |
| COAD | chr5 | 112839627 | Nonsense_Mutation | NA | E1345* | 0.81 | |
| COAD | chr5 | 112839693 | Nonsense_Mutation | rs121913328 | Q1367* | 0.13 | |
| COAD | chr5 | 112839942 | Nonsense_Mutation | rs121913332 | R1450* | 0.24 | |
| COAD | chr5 | 112840063 | Frame_Shift_Ins | NA | A1492Cfs*22 | 0.19 | |
| COAD | chr5 | 112838220 | Nonsense_Mutation | rs121913333 | R876* | 0.25 | |
| COAD | chr5 | 112840059 | Frame_Shift_Del | NA | L1489Yfs*18 | 0.28 | |
| COAD | chr5 | 112841332 | Missense_Mutation | novel | I1913T | 0.3 | |
| COAD | chr5 | 112838215 | Nonsense_Mutation | novel | S874* | 0.19 | |
| COAD | chr5 | 112839816 | Nonsense_Mutation | NA | E1408* | 0.38 | |
| COAD | chr5 | 112837863 | Nonsense_Mutation | NA | Q757* | 0.51 | |
| COAD | chr5 | 112840069 | Frame_Shift_Del | NA | T1493Rfs*14 | 0.2 | |
| COAD | chr5 | 112775678 | Frame_Shift_Del | novel | Y158Ifs*12 | 0.67 | |
| COAD | chr5 | 112792445 | Splice_Site | rs78847145 | X216_splice | 0.18 | |
| COAD | chr5 | 112837933 | Frame_Shift_Ins | novel | H785Qfs*6 | 0.49 | |
| COAD | chr5 | 112839835 | Frame_Shift_Del | NA | V1414Efs*5 | 0.58 | |
| COAD | chr5 | 112819074 | Nonsense_Mutation | NA | R348* | 0.09 | |
| COAD | chr5 | 112838008 | Missense_Mutation | rs200593940 | R805Q | 0.15 | |
| COAD | chr5 | 112839769 | Nonsense_Mutation | rs786204170 | S1392* | 0.18 | |
| COAD | chr5 | 112839942 | Nonsense_Mutation | rs121913332 | R1450* | 0.17 | |
| COAD | chr5 | 112840300 | Missense_Mutation | NA | D1569A | 0.11 | |
| COAD | chr5 | 112842514 | Missense_Mutation | NA | S2307L | 0.21 | |
| COAD | chr5 | 112844040 | Nonsense_Mutation | NA | R2816* | 0.22 | |
| COAD | chr5 | 112838007 | Nonsense_Mutation | rs587779783 | R805* | 0.48 | |
| COAD | chr5 | 112839950 | Frame_Shift_Del | NA | P1453Lfs*20 | 0.43 | |
| COAD | chr5 | 112792446 | Nonsense_Mutation | rs62619935 | R216* | 0.3 | |
| COAD | chr5 | 112839651 | Nonsense_Mutation | NA | E1353* | 0.26 | |
| COAD | chr5 | 112838413 | Nonsense_Mutation | NA | S940* | 0.17 | |
| COAD | chr5 | 112837900 | Nonsense_Mutation | novel | L769* | 0.56 | |
| COAD | chr5 | 112839627 | Nonsense_Mutation | NA | E1345* | 0.31 | |
| COAD | chr5 | 112839783 | Nonsense_Mutation | NA | E1397* | 0.88 | |
| COAD | chr5 | 112838397 | Nonsense_Mutation | NA | Y935* | 0.45 | |
| COAD | chr5 | 112839661 | Nonsense_Mutation | NA | S1356* | 0.41 | |
| COAD | chr5 | 112838140 | Frame_Shift_Ins | novel | R854Vfs*10 | 0.3 | |
| COAD | chr5 | 112839816 | Nonsense_Mutation | NA | E1408* | 0.3 | |
| COAD | chr5 | 112834979 | Missense_Mutation | novel | A591V | 0.38 | |
| COAD | chr5 | 112839175 | Nonsense_Mutation | NA | S1194* | 0.37 | |
| COAD | chr5 | 112840254 | Frame_Shift_Ins | NA | T1556Nfs*3 | 0.26 | |
| COAD | chr5 | 112842303 | Nonsense_Mutation | rs768922431 | R2237* | 0.26 | |
| COAD | chr5 | 112842514 | Missense_Mutation | NA | S2307L | 0.26 | |
| COAD | chr5 | 112835063 | Missense_Mutation | novel | T619N | 0.07 | |
| COAD | chr5 | 112838134 | Frame_Shift_Del | NA | D849Ifs*12 | 0.35 | |
| COAD | chr5 | 112840131 | Nonsense_Mutation | NA | E1513* | 0.36 | |
| COAD | chr5 | 112841716 | Missense_Mutation | novel | E2041G | 0.04 | |
| COAD | chr5 | 112842065 | Missense_Mutation | novel | K2157N | 0.07 | |
| COAD | chr5 | 112792504 | Nonsense_Mutation | NA | L235* | 0.34 | |
| COAD | chr5 | 112839606 | Nonsense_Mutation | rs121913327 | Q1338* | 0.47 | |
| COAD | chr5 | 112792494 | Nonsense_Mutation | rs397515734 | R232* | 0.81 | |
| COAD | chr5 | 112819261 | Nonsense_Mutation | novel | L410* | 0.64 | |
| COAD | chr5 | 112838569 | Frame_Shift_Ins | NA | K993* | 0.18 | |
| COAD | chr5 | 112780895 | Nonsense_Mutation | rs587781392 | R213* | 0.19 | |
| COAD | chr5 | 112840063 | Frame_Shift_Ins | NA | A1492Cfs*22 | 0.39 | |
| COAD | chr5 | 112839741 | Frame_Shift_Ins | NA | M1383Ifs*3 | 0.64 | |
| COAD | chr5 | 112792494 | Nonsense_Mutation | rs397515734 | R232* | 0.36 | |
| COAD | chr5 | 112839171 | Nonsense_Mutation | NA | Q1193* | 0.4 | |
| COAD | chr5 | 112838934 | Nonsense_Mutation | rs121913331 | R1114* | 0.19 | |
| COAD | chr5 | 112839909 | Frame_Shift_Del | NA | P1439Lfs*34 | 0.25 | |
| COAD | chr5 | 112837885 | Nonsense_Mutation | NA | L764* | 0.28 | |
| COAD | chr5 | 112840254 | Frame_Shift_Ins | NA | T1556Nfs*3 | 0.32 | |
| COAD | chr5 | 112828919 | Nonsense_Mutation | rs137854574 | R564* | 0.45 | |
| COAD | chr5 | 112839793 | Frame_Shift_Del | NA | S1400* | 0.45 | |
| COAD | chr5 | 112839816 | Nonsense_Mutation | NA | E1408* | 0.66 | |
| COAD | chr5 | 112838934 | Nonsense_Mutation | rs121913331 | R1114* | 0.31 | |
| COAD | chr5 | 112841063 | Missense_Mutation | novel | F1823L | 0.07 | |
| COAD | chr5 | 112839783 | Nonsense_Mutation | NA | E1397* | 0.57 | |
| COAD | chr5 | 112838331 | Frame_Shift_Del | novel | H913Ifs*3 | 0.31 | |
| COAD | chr5 | 112839942 | Nonsense_Mutation | rs121913332 | R1450* | 0.53 | |
| COAD | chr5 | 112839096 | Nonsense_Mutation | NA | E1168* | 0.5 | |
| COAD | chr5 | 112839908 | Frame_Shift_Del | NA | P1439Lfs*34 | 0.34 | |
| COAD | chr5 | 112840068 | Frame_Shift_Del | NA | A1492Pfs*15 | 0.69 | |
| COAD | chr5 | 112839834 | Missense_Mutation | NA | V1414L | 0.31 | |
| COAD | chr5 | 112839835 | Missense_Mutation | NA | V1414G | 0.32 | |
| COAD | chr5 | 112827107 | Splice_Site | NA | X470_splice | 0.36 | |
| COAD | chr5 | 112839942 | Nonsense_Mutation | rs121913332 | R1450* | 0.28 | |
| COAD | chr5 | 112838399 | Nonsense_Mutation | rs137854575 | Y935* | 0.38 | |
| COAD | chr5 | 112839931 | Frame_Shift_Del | NA | A1446Vfs*27 | 0.38 | |
| COAD | chr5 | 112838397 | Nonsense_Mutation | NA | Y935* | 0.35 | |
| COAD | chr5 | 112815564 | Nonsense_Mutation | rs137854568 | R302* | 0.44 | |
| COAD | chr5 | 112839693 | Nonsense_Mutation | rs121913328 | Q1367* | 0.55 | |
| COAD | chr5 | 112839436 | Nonsense_Mutation | NA | S1281* | 0.26 | |
| COAD | chr5 | 112839816 | Nonsense_Mutation | NA | E1408* | 0.29 | |
| COAD | chr5 | 112842169 | Missense_Mutation | NA | K2192T | 0.2 | |
| COAD | chr5 | 112843995 | Missense_Mutation | novel | R2801W | 0.07 | |
| COAD | chr5 | 112838007 | Nonsense_Mutation | rs587779783 | R805* | 0.34 | |
| COAD | chr5 | 112839942 | Nonsense_Mutation | rs121913332 | R1450* | 0.31 | |
| COAD | chr5 | 112839844 | Frame_Shift_Ins | NA | S1419* | 0.33 | |
| COAD | chr5 | 112835166 | Splice_Site | NA | X653_splice | 0.38 | |
| COAD | chr5 | 112792494 | Nonsense_Mutation | rs397515734 | R232* | 0.49 | |
| COAD | chr5 | 112755020 | Missense_Mutation | NA | M44V | 0.17 | |
| COAD | chr5 | 112838793 | Frame_Shift_Ins | novel | Q1067Lfs*14 | 0.06 | |
| COAD | chr5 | 112838794 | Frame_Shift_Ins | novel | Q1067Hfs*64 | 0.06 | |
| COAD | chr5 | 112819346 | Splice_Site | novel | X438_splice | 0.86 | |
| COAD | chr5 | 112792494 | Nonsense_Mutation | rs397515734 | R232* | 0.32 | |
| COAD | chr5 | 112839465 | Nonsense_Mutation | NA | Q1291* | 0.23 | |
| COAD | chr5 | 112841229 | Missense_Mutation | rs587779799 | A1879S | 0.17 | |
| COAD | chr5 | 112780895 | Nonsense_Mutation | rs587781392 | R213* | 0.77 | |
| COAD | chr5 | 112840220 | Frame_Shift_Del | novel | E1544Nfs*21 | 0.05 | |
| COAD | chr5 | 112838330 | Frame_Shift_Del | NA | H913Qfs*39 | 0.23 | |
| COAD | chr5 | 112839942 | Nonsense_Mutation | rs121913332 | R1450* | 0.48 | |
| COAD | chr5 | 112780862 | Frame_Shift_Ins | NA | Q203Tfs*49 | 0.39 | |
| COAD | chr5 | 112819245 | Nonsense_Mutation | rs587779780 | R405* | 0.23 | |
| COAD | chr5 | 112815494 | Splice_Site | novel | X279_splice | 0.38 | |
| COAD | chr5 | 112839749 | Frame_Shift_Ins | NA | C1387* | 0.31 | |
| COAD | chr5 | 112838220 | Nonsense_Mutation | rs121913333 | R876* | 0.21 | |
| COAD | chr5 | 112840254 | Frame_Shift_Ins | NA | T1556Nfs*3 | 0.6 | |
| COAD | chr5 | 112839035 | Nonsense_Mutation | novel | Y1147* | 0.31 | |
| COAD | chr5 | 112828889 | Nonsense_Mutation | rs137854573 | R554* | 0.37 | |
| COAD | chr5 | 112838140 | Frame_Shift_Del | novel | D849Vfs*12 | 0.61 | |
| COAD | chr5 | 112838086 | Frame_Shift_Ins | novel | P832Tfs*12 | 0.16 | |
| COAD | chr5 | 112839897 | Frame_Shift_Del | NA | R1435Efs*38 | 0.41 | |
| COAD | chr5 | 112838413 | Nonsense_Mutation | NA | S940* | 0.39 | |
| COAD | chr5 | 112792494 | Nonsense_Mutation | rs397515734 | R232* | 0.25 | |
| COAD | chr5 | 112815507 | Nonsense_Mutation | rs786201856 | R283* | 0.23 | |
| COAD | chr5 | 112828919 | Nonsense_Mutation | rs137854574 | R564* | 0.39 | |
| COAD | chr5 | 112839783 | Nonsense_Mutation | NA | E1397* | 0.17 | |
| COAD | chr5 | 112792446 | Nonsense_Mutation | rs62619935 | R216* | 0.25 | |
| COAD | chr5 | 112839526 | Frame_Shift_Del | NA | I1311Rfs*3 | 0.46 | |
| COAD | chr5 | 112840254 | Frame_Shift_Ins | NA | T1556Nfs*3 | 0.44 | |
| COAD | chr5 | 112839908 | Frame_Shift_Del | NA | P1439Lfs*34 | 0.68 | |
| COAD | chr5 | 112834969 | Frame_Shift_Del | novel | V588Yfs*2 | 0.23 | |
| COAD | chr5 | 112839506 | Frame_Shift_Del | NA | I1304Mfs*4 | 0.28 | |
| COAD | chr5 | 112839519 | Nonsense_Mutation | NA | E1309* | 0.77 | |
| COAD | chr5 | 112838220 | Nonsense_Mutation | rs121913333 | R876* | 0.32 | |
| COAD | chr5 | 112840060 | Frame_Shift_Ins | NA | H1490Tfs*24 | 0.23 | |
| COAD | chr5 | 112840254 | Frame_Shift_Ins | NA | T1556Nfs*3 | 0.75 | |
| COAD | chr5 | 112838133 | Frame_Shift_Ins | NA | D849Rfs*2 | 0.3 | |
| COAD | chr5 | 112838740 | Nonsense_Mutation | NA | W1049* | 0.49 | |
| COAD | chr5 | 112839816 | Nonsense_Mutation | NA | E1408* | 0.44 | |
| COAD | chr5 | 112838415 | Nonsense_Mutation | NA | E941* | 0.75 | |
| COAD | chr5 | 112838422 | Nonsense_Mutation | NA | S943* | 0.29 | |
| COAD | chr5 | 112839879 | Nonsense_Mutation | rs74535574 | Q1429* | 0.22 | |
| COAD | chr5 | 112838415 | Nonsense_Mutation | NA | E941* | 0.48 | |
| COAD | chr5 | 112839909 | Frame_Shift_Del | NA | P1439Lfs*34 | 0.33 | |
| COAD | chr5 | 112837920 | Frame_Shift_Ins | novel | D777* | 0.37 | |
| COAD | chr5 | 112839702 | Nonsense_Mutation | NA | K1370* | 0.59 | |
| DLBC | chr5 | 112837797 | Missense_Mutation | novel | A735T | 0.3 | |
| ESCA | chr5 | 112841134 | Missense_Mutation | rs371686531 | T1847M | 0.33 | |
| ESCA | chr5 | 112840254 | Frame_Shift_Ins | NA | T1556Nfs*3 | 0.78 | |
| ESCA | chr5 | 112839976 | Frame_Shift_Del | NA | K1462Efs*6 | 0.28 | |
| ESCA | chr5 | 112815531 | Frame_Shift_Ins | NA | L292Ffs*4 | 0.55 | |
| ESCA | chr5 | 112835045 | Frame_Shift_Del | novel | A614Hfs*16 | 0.51 | |
| ESCA | chr5 | 112838307 | Missense_Mutation | novel | S905R | 0.23 | |
| ESCA | chr5 | 112819025 | Silent | rs148343173 | S331S | 0.34 | |
| ESCA | chr5 | 112819244 | Silent | novel | I404I | 0.33 | |
| ESCA | chr5 | 112840254 | Frame_Shift_Ins | NA | T1556Nfs*3 | 0.8 | |
| ESCA | chr5 | 112838571 | Missense_Mutation | NA | K993Q | 0.3 | |
| GBM | chr5 | 112839105 | Missense_Mutation | rs201830995 | R1171C | 0.27 | |
| GBM | chr5 | 112842299 | Frame_Shift_Ins | novel | V2236Sfs*44 | 0.03 | |
| GBM | chr5 | 112843231 | Missense_Mutation | novel | T2546I | 0.05 | |
| GBM | chr5 | 112839509 | Silent | novel | A1305A | 0.03 | |
| GBM | chr5 | 112838585 | Silent | NA | Y997Y | 0.48 | |
| GBM | chr5 | 112767242 | Missense_Mutation | novel | S92P | 0.61 | |
| GBM | chr5 | 112819128 | Missense_Mutation | novel | D366Y | 0.17 | |
| GBM | chr5 | 112838311 | Missense_Mutation | NA | S906Y | 0.5 | |
| GBM | chr5 | 112839989 | Silent | novel | S1465S | 0.18 | |
| GBM | chr5 | 112843870 | Missense_Mutation | rs538289470 | R2759H | 0.18 | |
| GBM | chr5 | 112839894 | Missense_Mutation | NA | S1434G | 0.36 | |
| GBM | chr5 | 112839292 | Missense_Mutation | novel | P1233R | 0.1 | |
| GBM | chr5 | 112839235 | Missense_Mutation | novel | S1214I | 0.03 | |
| GBM | chr5 | 112840936 | Missense_Mutation | novel | Q1781P | 0.05 | |
| GBM | chr5 | 112840173 | Frame_Shift_Ins | novel | P1527Hfs*6 | 0.12 | |
| GBM | chr5 | 112839249 | Missense_Mutation | NA | S1219T | 0.05 | |
| GBM | chr5 | 112839735 | Missense_Mutation | rs730881250 | P1381T | 0.32 | |
| GBM | chr5 | 112840151 | Frame_Shift_Del | novel | D1519Efs*4 | 0.11 | |
| GBM | chr5 | 112838635 | Missense_Mutation | novel | M1014T | 0.11 | |
| GBM | chr5 | 112838847 | Missense_Mutation | novel | K1085Q | 0.03 | |
| GBM | chr5 | 112838323 | Missense_Mutation | novel | T910N | 0.11 | |
| GBM | chr5 | 112837582 | Missense_Mutation | novel | Q663R | 0.05 | |
| GBM | chr5 | 112839899 | Missense_Mutation | novel | R1435S | 0.07 | |
| GBM | chr5 | 112843384 | Missense_Mutation | novel | G2597A | 0.15 | |
| HNSC | chr5 | 112838253 | Missense_Mutation | novel | I887F | 0.26 | |
| HNSC | chr5 | 112767374 | Missense_Mutation | novel | E136K | 0.13 | |
| HNSC | chr5 | 112840074 | Missense_Mutation | novel | E1494Q | 0.16 | |
| HNSC | chr5 | 112839518 | Silent | novel | K1308K | 0.86 | |
| HNSC | chr5 | 112838950 | Missense_Mutation | novel | H1119R | 0.09 | |
| HNSC | chr5 | 112767376 | Silent | novel | E136E | 0.12 | |
| HNSC | chr5 | 112839225 | Missense_Mutation | rs780084585 | M1211V | 0.15 | |
| HNSC | chr5 | 112841643 | Missense_Mutation | novel | T2017A | 0.27 | |
| HNSC | chr5 | 112815508 | Missense_Mutation | rs149154604 | R283Q | 0.39 | |
| HNSC | chr5 | 112840689 | Missense_Mutation | novel | E1699K | 0.21 | |
| HNSC | chr5 | 112841181 | In_Frame_Ins | novel | S1863delinsNLC | 0.11 | |
| HNSC | chr5 | 112839732 | Missense_Mutation | novel | T1380P | 0.28 | |
| HNSC | chr5 | 112841873 | Silent | novel | S2093S | 0.33 | |
| HNSC | chr5 | 112841373 | Missense_Mutation | novel | L1927F | 0.26 | |
| HNSC | chr5 | 112838679 | Missense_Mutation | novel | L1029I | 0.08 | |
| HNSC | chr5 | 112801329 | Missense_Mutation | novel | Q260H | 0.31 | |
| HNSC | chr5 | 112766410 | Splice_Region | novel | E74delinsAQ | 0.12 | |
| HNSC | chr5 | 112835024 | Nonsense_Mutation | novel | I606_C607insE* | 0.09 | |
| HNSC | chr5 | 112838119 | Missense_Mutation | NA | D842V | 0.27 | |
| HNSC | chr5 | 112840254 | Frame_Shift_Ins | NA | T1556Nfs*3 | 0.74 | |
| HNSC | chr5 | 112840149 | Frame_Shift_Del | NA | D1519Mfs*4 | 0.28 | |
| HNSC | chr5 | 112840290 | Missense_Mutation | novel | D1566Y | 0.12 | |
| HNSC | chr5 | 112840294 | Nonsense_Mutation | NA | S1567* | 0.68 | |
| HNSC | chr5 | 112841811 | Missense_Mutation | novel</ |
