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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
24217660Mdm2 SNP309 G-variant is associated with invasive growth of human urinary bladder cancer.Pathobiology2014Hitzenbichler Fdoi: 10.1159/000355976
12138177Transcriptional regulation of the mdm2 oncogene by p53 requires TRRAP acetyltransferase complexes.Mol Cell Biol2002 AugArd PG-
26476535Interaction between p53 codon 72 and MDM2 309T>G polymorphisms and the risk of hepatocellular carcinoma.Tumour Biol2016 MarQiu Mdoi: 10.1007/s13277-015-4222-4
15734740Relief of p53-mediated telomerase suppression by p73.J Biol Chem2005 Apr 29Toh WH-
19541936NOLC1, an enhancer of nasopharyngeal carcinoma progression, is essential for TP53 to regulate MDM2 expression.Am J Pathol2009 JulHwang YCdoi: 10.2353/ajpath.2009.080931
17848574MDM2 chaperones the p53 tumor suppressor.J Biol Chem2007 Nov 9Wawrzynow B-
24632578Combined effects of genetic variants of the PTEN, AKT1, MDM2 and p53 genes on the risk of nasopharyngeal carcinoma.PLoS One2014 Mar 14Zhang Xdoi: 10.1371/journal.pone.0092135
19379464Murine double-minute 2 homolog single nucleotide polymorphism 309 and the risk of gynecologic cancer.Hum Cell2009 MayUeda Mdoi: 10.1111/j.1749-0774.2009.00068.x.
20358297ARLTS1, MDM2 and RAD51 gene variations are associated with familial breast cancer.Mol Biol Rep2011 JanAkisik Edoi: 10.1007/s11033-010-0113-3
21667122Association of the germline TP53 R72P and MDM2 SNP309 variants with breast cancer survival in specific breast tumor subgroups.Breast Cancer Res Treat2011 Novvan den Broek AJdoi: 10.1007/s10549-011-1615-y
23210739Association of MDM2 and p53 polymorphisms with the advancement of cervical carcinoma.DNA Cell Biol2013 JanSinghal Pdoi: 10.1089/dna.2012.1718
26796597MDM2 gene amplification in esophageal carcinoma.Oncol Rep2016 AprMichalk Mdoi: 10.3892/or.2016.4578
25136862MicroRNA-410 suppresses migration and invasion by targeting MDM2 in gastric cancer.PLoS One2014 Aug 19Shen Jdoi: 10.1371/journal.pone.0104510
28741571RP-MDM2-p53 Pathway: Linking Ribosomal Biogenesis and Tumor Surveillance.Trends Cancer2016 AprLiu Ydoi: 10.1016/j.trecan.2016.03.002
18487080Combined effects of MDM2 SNP 309 and p53 mutation on oral squamous cell carcinomas associated with areca quid chewing.Oral Oncol2009 JanHuang SFdoi: 10.1016/j.oraloncology.2008.03.006
28692049Mdm2 selectively suppresses DNA damage arising from inhibition of topoisomerase II independent of p53.Oncogene2017 Nov 2Senturk JCdoi: 10.1038/onc.2017.229
29651441STAT1, IGF1, RAC1, and MDM2 Are Associated with Recurrence of Giant Cell Tumor of Bone.J Immunol Res2018 Jan 31Chen Sdoi: 10.1155/2018/4564328
25176350Several fusion genes identified by whole transcriptome sequencing in a spindle cell sarcoma with rearrangements of chromosome arm 12q and MDM2 amplification.Int J Oncol2014 NovPanagopoulos Idoi: 10.3892/ijo.2014.2605
12150820Alternative and aberrant splicing of MDM2 mRNA in human cancer.Cancer Cell2002 JulBartel F-
26431163Mdm2 inhibition confers protection of p53-proficient cells from the cytotoxic effects of Wee1 inhibitors.Oncotarget2015 Oct 20Li Ydoi: 10.18632/oncotarget.5891.
26840476ASSOCIATION BETWEEN MURINE DOUBLE MINUTE 2 - T309G polymorphism and recurrence of hepatocellular carcinoma after surgical treatment.Arq Gastroenterol2015 DecTeixeira UFdoi: 10.1590/S0004-28032015000400014.
24361594DNAJB1 stabilizes MDM2 and contributes to cancer cell proliferation in a p53-dependent manner.Biochim Biophys Acta2014 JanQi Mdoi: 10.1016/j.bbagrm.2013.12.003
20708156Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase.Cancer Cell2010 Aug 9Inuzuka Hdoi: 10.1016/j.ccr.2010.06.015.
21986500MDM2 regulates vascular endothelial growth factor mRNA stabilization in hypoxia.Mol Cell Biol2011 DecZhou Sdoi: 10.1128/MCB.06085-11
18809412Intrinsically unstructured domains of Arf and Hdm2 form bimolecular oligomeric structures in vitro and in vivo.J Mol Biol2008 Dec 5Sivakolundu SGdoi: 10.1016/j.jmb.2008.09.019
24240108HDM2 regulation by AURKA promotes cell survival in gastric cancer.Clin Cancer Res2014 Jan 1Sehdev Vdoi: 10.1158/1078-0432.CCR-13-1187
20849851Counteracting MDM2-induced HIPK2 downregulation restores HIPK2/p53 apoptotic signaling in cancer cells.FEBS Lett2010 Oct 8Nardinocchi Ldoi: 10.1016/j.febslet.2010.09.018
19946469Alterations in gene expression and sensitivity to genotoxic stress following HdmX or Hdm2 knockdown in human tumor cells harboring wild-type p53.Aging (Albany NY)2009 JanHeminger K-
18607552MDM2 mRNA expression in the p53 pathway may predict the potential of invasion and liver metastasis in colorectal cancer.Dis Colon Rectum2008 SepKondo Idoi: 10.1007/s10350-008-9382-5
18572327Relationship of Ki67, TP53, MDM-2 and BCL-2 expressions with WHO 1973 and WHO/ISUP grades, tumor category and overall patient survival in urothelial tumors of the bladder.Pathol Res Pract2008Gonul IIdoi: 10.1016/j.prp.2008.03.011
22939400The MDM2 SNP309 G allele is not preferentially amplified in bone and soft tissue tumors.Cancer Genet2012 SepMertens Fdoi: 10.1016/j.cancergen.2012.06.001.
17846171A novel role for IGF-1R in p53-mediated apoptosis through translational modulation of the p53-Mdm2 feedback loop.J Cell Biol2007 Sep 10Xiong L-
15448710MDM2 expression in EBV-infected nasopharyngeal carcinoma cells.Lab Invest2004 DecWu HC-
17827408MDM2 SNP309 and cancer risk: a combined analysis.Carcinogenesis2007 NovWilkening S-
25605253Selective inhibition of histone deacetylase 2 induces p53-dependent survivin downregulation through MDM2 proteasomal degradation.Oncotarget2015 Sep 22Seo SKdoi: 10.18632/oncotarget.3100.
22699518Sensitivity of MDM2 amplification and unexpected multiple faint alphoid 12 (alpha 12 satellite sequences) signals in atypical lipomatous tumor.Mod Pathol2012 OctKashima Tdoi: 10.1038/modpathol.2012.90
17139261p53 mediates the negative regulation of MDM2 by orphan receptor TR3.EMBO J2006 Dec 13Zhao BX-
18519749Impact of a single nucleotide polymorphism in the MDM2 gene on neuroblastoma development and aggressiveness: results of a pilot study on 239 patients.Clin Cancer Res2008 Jun 1Cattelani Sdoi: 10.1158/1078-0432.CCR-07-4725.
16479015Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.Mol Cell Biol2006 MarDing Y-
23786219A potent small-molecule inhibitor of the MDM2-p53 interaction (MI-888) achieved complete and durable tumor regression in mice.J Med Chem2013 Jul 11Zhao Ydoi: 10.1021/jm4005708
22397410Golgi-SNARE GS28 potentiates cisplatin-induced apoptosis by forming GS28-MDM2-p53 complexes and by preventing the ubiquitination and degradation of p53.Biochem J2012 Jun 1Sun NKdoi: 10.1042/BJ20112223.
27129219HBP1-mediated Regulation of p21 Protein through the Mdm2/p53 and TCF4/EZH2 Pathways and Its Impact on Cell Senescence and Tumorigenesis.J Biol Chem2016 Jun 10Chen Ydoi: 10.1074/jbc.M116.714147
23802716Synthesis, in vitro, and in cell studies of a new series of [indoline-3,2'-thiazolidine]-based p53 modulators.J Med Chem2013 Jul 11Bertamino Adoi: 10.1021/jm400311n
18504050Identification of HDM2 as a regulator of VEGF expression in cancer cells.Life Sci2008 Jun 20Narasimhan Mdoi: 10.1016/j.lfs.2008.04.004
19752772MDM2 SNP309 associates with accelerated pancreatic adenocarcinoma formation.Pancreas2010 JanGrochola LFdoi: 10.1097/MPA.0b013e3181b9f105.
20528739Regulation of the p53 tumor suppressor pathway: the problems and promises of studying Mdm2's E3 ligase function.Crit Rev Eukaryot Gene Expr2010Clegg HV-
18356162Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 binding.J Biol Chem2008 May 16Lopez-Pajares Vdoi: 10.1074/jbc.M710030200
24413081Regulation of Mdm2 protein stability and the p53 response by NEDD4-1 E3 ligase.Oncogene2015 Jan 15Xu Cdoi: 10.1038/onc.2013.557
23060298Gastrointestinal stromal tumors: clinical significance of p53 expression, MDM2 amplification, and KIT mutation status.Appl Immunohistochem Mol Morphol2013 JulWallander MLdoi: 10.1097/PAI.0b013e31826ea7c0.
26138282Microsecond simulations of mdm2 and its complex with p53 yield insight into force field accuracy and conformational dynamics.Proteins2015 SepPantelopulos GAdoi: 10.1002/prot.24852
26070072Significant Differences in the Development of Acquired Resistance to the MDM2 Inhibitor SAR405838 between In Vitro and In Vivo Drug Treatment.PLoS One2015 Jun 12Hoffman-Luca CGdoi: 10.1371/journal.pone.0128807
18234968The oncoprotein SS18-SSX1 promotes p53 ubiquitination and degradation by enhancing HDM2 stability.Mol Cancer Res2008 JanD'Arcy Pdoi: 10.1158/1541-7786.MCR-07-0176.
12208736The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2.Cancer Res2002 Sep 1Leung KM-
16738062p19ras brings a new twist to the regulation of p73 by Mdm2.Sci STKE2006 May 30Harms KL-
15720184MDM2 is a central node in the p53 pathway: 12 years and counting.Curr Cancer Drug Targets2005 FebBond GL-
16027727Rescue of Mdm4-deficient mice by Mdm2 reveals functional overlap of Mdm2 and Mdm4 in development.Oncogene2005 Nov 24Steinman HA-
20881839Automated brightfield dual-color in situ hybridization for detection of mouse double minute 2 gene amplification in sarcomas.Appl Immunohistochem Mol Morphol2011 JanZhang Wdoi: 10.1097/PAI.0b013e3181ee8e14.
22333590Mutational analysis of Mdm2 C-terminal tail suggests an evolutionarily conserved role of its length in Mdm2 activity toward p53 and indicates structural differences between Mdm2 homodimers and Mdm2/MdmX heterodimers.Cell Cycle2012 Mar 1Dolezelova Pdoi: 10.4161/cc.11.5.19445
26482041Preclinical Efficacy of the MDM2 Inhibitor RG7112 in MDM2-Amplified and TP53 Wild-type Glioblastomas.Clin Cancer Res2016 Mar 1Verreault Mdoi: 10.1158/1078-0432.CCR-15-1015
18086778MDM2 promoter polymorphism SNP309 contributes to tumor susceptibility: evidence from 21 case-control studies.Cancer Epidemiol Biomarkers Prev2007 DecHu Z-
25915849Mdm2 overexpression and p73 loss exacerbate genomic instability and dampen apoptosis, resulting in B-cell lymphoma.Oncogene2016 Jan 21Riley MFdoi: 10.1038/onc.2015.88
15943041A comparative study of P53/MDM2 genes alterations and P53/MDM2 proteins immunoreactivity in liver cirrhosis and hepatocellular carcinoma.J Exp Clin Cancer Res2005 MarJablkowski M-
22510592Combination of radiotherapy and adenovirus-mediated p53 gene therapy for MDM2-overexpressing hepatocellular carcinoma.J Radiat Res2012Koom WS-
20431480Liposarcomas with mixed well-differentiated and pleomorphic features: a clinicopathologic study of 12 cases.Am J Surg Pathol2010 JunBoland JMdoi: 10.1097/PAS.0b013e3181dbf2f7.
20849854Overexpression of SCYL1-BP1 stabilizes functional p53 by suppressing MDM2-mediated ubiquitination.FEBS Lett2010 Oct 22Yan Jdoi: 10.1016/j.febslet.2010.09.019
22095636Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation.Hepatology2012 AprEmbade Ndoi: 10.1002/hep.24795
22200978RNA interference against MDM2 suppresses tumor growth and metastasis in pancreatic carcinoma SW1990HM cells.Mol Cell Biochem2014 FebShi Wdoi: 10.1007/s11010-011-1208-4
23506010Pleomorphic fibroma and dermal atypical lipomatous tumor: are they related?J Cutan Pathol2013 AprAl-Zaid Tdoi: 10.1111/cup.12095.
23438693Mdm2 increases cellular invasiveness by binding to and stabilizing the Slug mRNA.Cancer Lett2013 Jul 28Jung CHdoi: 10.1016/j.canlet.2013.02.035
23391506Stress response of glioblastoma cells mediated by miR-17-5p targeting PTEN and the passenger strand miR-17-3p targeting MDM2.Oncotarget2012 DecLi H-
17671677Overexpression of small ubiquitin-related modifier-1 and sumoylated Mdm2 in oral squamous cell carcinoma: possible involvement in tumor proliferation and prognosis.Int J Oncol2007 SepKatayama A-
26802432Aberrant splicing of the DMP1-ARF-MDM2-p53 pathway in cancer.Int J Cancer2016 Jul 1Inoue Kdoi: 10.1002/ijc.30003
21317535Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers.J Clin Invest2011 MarZhao Rdoi: 10.1172/JCI44111
26984736Downregulation of LRRC8A protects human ovarian and alveolar carcinoma cells against Cisplatin-induced expression of p53, MDM2, p21Waf1/Cip1, and Caspase-9/-3 activation.Am J Physiol Cell Physiol2016 Jun 1Sorensen BHdoi: 10.1152/ajpcell.00256.2015
27485527MicroRNA-610 is downregulated in glioma cells, and inhibits proliferation and motility by directly targeting MDM2.Mol Med Rep2016 SepYan Ydoi: 10.3892/mmr.2016.5559
27508976MDM2 and CDK4 Immunohistochemistry: Should It Be Used in Problematic Differentiated Lipomatous Tumors?: A New Perspective.Am J Surg Pathol2016 DecClay MR-
28592528HDM2 Promotes NEDDylation of Hepatitis B Virus HBx To Enhance Its Stability and Function.J Virol2017 Jul 27Liu Ndoi: 10.1128/JVI.00340-17
27264869Chromatin-Bound MDM2 Regulates Serine Metabolism and Redox Homeostasis Independently of p53.Mol Cell2016 Jun 16Riscal Rdoi: 10.1016/j.molcel.2016.04.033
27597521Differential diagnosis of atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma: utility of p16 in combination with MDM2 and CDK4 immunohistochemistry.Hum Pathol2017 JanKammerer-Jacquet SFdoi: 10.1016/j.humpath.2016.08.009
26973248Scaffold protein FHL2 facilitates MDM2-mediated degradation of IER3 to regulate proliferation of cervical cancer cells.Oncogene2016 Sep 29Jin Hdoi: 10.1038/onc.2016.54
27036047Period2 downregulation inhibits glioma cell apoptosis by activating the MDM2-TP53 pathway.Oncotarget2016 May 10Zhanfeng Ndoi: 10.18632/oncotarget.8439.
27550999Therapeutic Inhibition of the MDM2-p53 Interaction Prevents Recurrence of Adenoid Cystic Carcinomas.Clin Cancer Res2017 Feb 15Nor Fdoi: 10.1158/1078-0432.CCR-16-1235
28035066Estradiol shows anti-skin cancer activities through decreasing MDM2 expression.Oncotarget2017 Jan 31Li Ldoi: 10.18632/oncotarget.14275.
28351930Hyperprogressors after Immunotherapy: Analysis of Genomic Alterations Associated with Accelerated Growth Rate.Clin Cancer Res2017 Aug 1Kato Sdoi: 10.1158/1078-0432.CCR-16-3133
29793321Micro RNA-518 inhibits gastric cancer cell growth by inducing apoptosis via targeting MDM2.Biomed Pharmacother2018 JanFeng Cdoi: 10.1016/j.biopha.2017.11.091
28892044A novel mouse model of rhabdomyosarcoma underscores the dichotomy of MDM2-ALT1 function in vivo.Oncogene2018 Jan 4Comiskey DF Jrdoi: 10.1038/onc.2017.282
30544386Association between MDM2 SNP309 and endometrial cancer risk: A PRISMA-compliant meta-analysis.Medicine (Baltimore)2018 DecZou Xdoi: 10.1097/MD.0000000000013273.
29309298Clarifying the Distinction Between Malignant Peripheral Nerve Sheath Tumor and Dedifferentiated Liposarcoma: A Critical Reappraisal of the Diagnostic Utility of MDM2 and H3K27me3 Status.Am J Surg Pathol2018 MayMakise Ndoi: 10.1097/PAS.0000000000001014.
30454706Combinatory inhibition of TRIM65 and MDM2 in lung cancer cells.Biochem Biophys Res Commun2018 Nov 30Chen Gdoi: 10.1016/j.bbrc.2018.10.130
21761395Identification of spliced variants of the proto-oncogene HDM2 in colorectal cancer.Cancer2012 Feb 15Yu Zdoi: 10.1002/cncr.26330
21656578Effects of MDM2 promoter polymorphisms and p53 codon 72 polymorphism on risk and age at onset of squamous cell carcinoma of the head and neck.Mol Carcinog2011 SepYu Hdoi: 10.1002/mc.20806
16934800Differential response between the p53 ubiquitin-protein ligases Pirh2 and MdM2 following DNA damage in human cancer cells.Exp Cell Res2006 Oct 15Duan W-
25326024A 40-bp insertion/deletion polymorphism of Murine Double Minute2 (MDM2) increased the risk of breast cancer in Zahedan, Southeast Iran.Iran Biomed J2014Hashemi M-
24777531USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses.Nat Immunol2014 JunZou Qdoi: 10.1038/ni.2885
26553387Clinical significance of TP53 (R72P) and MDM2 (T309G) polymorphisms in breast cancer patients.Clin Transl Oncol2016 JulYadav Pdoi: 10.1007/s12094-015-1425-5
18577987Mdm2-SNP309 polymorphism in prostate cancer: no evidence for association with increased risk or histopathological tumour characteristics.Br J Cancer2008 Jul 8Stoehr Rdoi: 10.1038/sj.bjc.6604441
25431177Influence of MDM2 SNP309 and SNP285 status on the risk of cancer in the breast, prostate, lung and colon.Int J Cancer2015 Jul 1Gansmo LBdoi: 10.1002/ijc.29358
24882579miR-339-5p regulates the p53 tumor-suppressor pathway by targeting MDM2.Oncogene2015 Apr 9Jansson MDdoi: 10.1038/onc.2014.130
26945408Is MDM2 SNP309 Variation a Risk Factor for Head and Neck Carcinoma?: An Updated Meta-Analysis Based on 11,552 Individuals.Medicine (Baltimore)2016 MarZhuo Xdoi: 10.1097/MD.0000000000002948.
27573292Inhibition of FOXQ1 induces apoptosis and suppresses proliferation in prostate cancer cells by controlling BCL11A/MDM2 expression.Oncol Rep2016 OctZhang Xdoi: 10.3892/or.2016.5018
21305319Joint effects of germ-line TP53 mutation, MDM2 SNP309, and gender on cancer risk in family studies of Li-Fraumeni syndrome.Hum Genet2011 JunWu CCdoi: 10.1007/s00439-011-0957-1
21316605The MDM2 promoter SNP285C/309G haplotype diminishes Sp1 transcription factor binding and reduces risk for breast and ovarian cancer in Caucasians.Cancer Cell2011 Feb 15Knappskog Sdoi: 10.1016/j.ccr.2010.12.019.
22729912Individual and combined effects of MDM2 SNP309 and TP53 Arg72Pro on breast cancer risk: an updated meta-analysis.Mol Biol Rep2012 SepCheng Hdoi: 10.1007/s11033-012-1800-z
19492228Cigarette smoking, MDM2 SNP309, gene-environment interactions, and lung cancer risk: a meta-analysis.J Toxicol Environ Health A2009Bai Jdoi: 10.1080/15287390902840930.
18332869Retinoblastoma protein modulates gankyrin-MDM2 in regulation of p53 stability and chemosensitivity in cancer cells.Oncogene2008 Jul 3Qiu Wdoi: 10.1038/onc.2008.43
26229107The oncoprotein HBXIP modulates the feedback loop of MDM2/p53 to enhance the growth of breast cancer.J Biol Chem2015 Sep 11Li Hdoi: 10.1074/jbc.M115.658468
27171940The MDM2 T309G polymorphism and risk of lung cancer: an updated meta-analysis of 10,186 cases and 14,155 controls.Panminerva Med2016 DecTian X-
27194168The Role of MDM2 Amplification and Overexpression in Tumorigenesis.Cold Spring Harb Perspect Med2016 Jun 1Oliner JDdoi: 10.1101/cshperspect.a026336.
28158999MDM2 promoter polymorphism del1518 (rs3730485) and its impact on endometrial and ovarian cancer risk.BMC Cancer2017 Feb 3Gansmo LBdoi: 10.1186/s12885-017-3094-y.
28498468MicroRNA-379-5p plays a tumor-suppressive role in human bladder cancer growth and metastasis by directly targeting MDM2.Oncol Rep2017 JunWu Ddoi: 10.3892/or.2017.5607
29480845Association of rs2279744 and rs117039649 promoter polymorphism with the risk of gynecological cancer: A meta-analysis of case-control studies.Medicine (Baltimore)2018 JanZhang Jdoi: 10.1097/MD.0000000000009554.
28667029Association of the Del1518 Promoter (rs3730485) Polymorphism in the MDM2 Gene with Breast Cancer in a Mexican Population.Ann Clin Lab Sci2017 MayGallegos-Arreola MP-
28784612Early-Stage Metastasis Requires Mdm2 and Not p53 Gain of Function.Mol Cancer Res2017 NovHauck PMdoi: 10.1158/1541-7786.MCR-17-0174
27624283MDM2 promoter SNP55 (rs2870820) affects risk of colon cancer but not breast-, lung-, or prostate cancer.Sci Rep2016 Sep 14Helwa Rdoi: 10.1038/srep33153.
30244662The Study of MDM2 rs937283 Variant and Cancer Susceptibility in a Central Chinese Population.Technol Cancer Res Treat2018 Jan 1Chen Bdoi: 10.1177/1533033818801550.
21444629Synergistic suppression of prostatic cancer cells by coexpression of both murine double minute 2 small interfering RNA and wild-type p53 gene in vitro and in vivo.J Pharmacol Exp Ther2011 JulJi Kdoi: 10.1124/jpet.111.180364
25201199Splice variants of MDM2 in oncogenesis.Subcell Biochem2014Rosso Mdoi: 10.1007/978-94-017-9211-0_14.
24236052MDM2 promotes invasion and metastasis in invasive ductal breast carcinoma by inducing matrix metalloproteinase-9.PLoS One2013 Nov 13Chen Xdoi: 10.1371/journal.pone.0078794
20370686Reactivation of p53 by novel MDM2 inhibitors: implications for pancreatic cancer therapy.Curr Cancer Drug Targets2010 MayAzmi AS-
21477265A single-nucleotide polymorphism in the TP53 and MDM-2 gene modifies breast cancer risk in an ethnic Arab population.Fundam Clin Pharmacol2012 JunAlshatwi AAdoi: 10.1111/j.1472-8206.2011.00939.x
23045280Prognostic value of the hDMP1-ARF-Hdm2-p53 pathway in breast cancer.Oncogene2013 Aug 29Maglic Ddoi: 10.1038/onc.2012.423
26411689LncRNA HOTAIR Enhances the Androgen-Receptor-Mediated Transcriptional Program and Drives Castration-Resistant Prostate Cancer.Cell Rep2015 Oct 6Zhang Adoi: 10.1016/j.celrep.2015.08.069
22266832Impact of MDM2 polymorphism: increased risk of developing colorectal cancer and a poor prognosis in the Tunisian population.Eur J Gastroenterol Hepatol2012 MarChaar Idoi: 10.1097/MEG.0b013e32834bdf84.
21877955Involvement of single-nucleotide polymorphisms in predisposition to head and neck cancer in Saudi Arabia.Genet Test Mol Biomarkers2012 FebAl-Hadyan KSdoi: 10.1089/gtmb.2011.0126
26350565The cholesterol metabolite 27-hydroxycholesterol regulates p53 activity and increases cell proliferation via MDM2 in breast cancer cells.Mol Cell Biochem2015 DecRaza Sdoi: 10.1007/s11010-015-2551-7
25479941Genetic association of single nucleotide polymorphisms in P53 pathway with gastric cancer risk in a Chinese Han population.Med Oncol2015 JanWu GCdoi: 10.1007/s12032-014-0401-1
23359199Association between MDM2 SNP309 polymorphism and endometrial cancer risk in Polish women.Pol J Pathol2012 DecZajac A-
20503107MDM2 309 T/G polymorphism is associated with colorectal cancer risk especially in Asians: a meta-analysis.Med Oncol2011 DecFang Fdoi: 10.1007/s12032-010-9577-1
18281248MDM2 SNP309 G allele increases risk but the T allele is associated with earlier onset age of sporadic breast cancers in the Chinese population.Carcinogenesis2008 AprLum SSdoi: 10.1093/carcin/bgn024
16825434Tumour selection advantage of non-dominant negative P53 mutations in homozygotic MDM2-SNP309 colorectal cancer cells.J Med Genet2007 JanAlazzouzi H-
25987086MDM2 (RS769412) G>A Polymorphism in Cigarette Smokers: a Clue for the Susceptibility to Smoking and Lung Cancer Risk.Asian Pac J Cancer Prev2015Ahmad D-
22716509Murine double minute 2 promoter SNP309 polymorphism and prostate cancer risk: a meta-analysis.Int J Urol2012 OctLiu Gdoi: 10.1111/j.1442-2042.2012.03067.x
24423195MDM2 SNP309 polymorphism contributes to endometrial cancer susceptibility: evidence from a meta-analysis.J Exp Clin Cancer Res2013 Nov 3Peng Qdoi: 10.1186/1756-9966-32-85.
19590949Differential effects of MDM2 SNP309 polymorphism on breast cancer risk along with race: a meta-analysis.Breast Cancer Res Treat2010 FebEconomopoulos KPdoi: 10.1007/s10549-009-0467-1
19144119Results based on 124 cases of breast cancer and 97 controls from Taiwan suggest that the single nucleotide polymorphism (SNP309) in the MDM2 gene promoter is associated with earlier onset and increased risk of breast cancer.BMC Cancer2009 Jan 13Sun YFdoi: 10.1186/1471-2407-9-13.
18023538No association between SNP309 promoter polymorphism in the MDM2 and cervical cancer in a study from northeastern Brazil.Cancer Detect Prev2007Meissner Rde V-
17094469MDM2 T309G polymorphism is associated with bladder cancer.Anticancer Res2006 Sep-OctOnat OE-
16496380Association of a functional polymorphism in the promoter of the MDM2 gene with risk of nonsmall cell lung cancer.Int J Cancer2006 Aug 1Lind H-
17957785Genetic polymorphisms of MDM2, cumulative cigarette smoking and nonsmall cell lung cancer risk.Int J Cancer2008 Feb 15Liu G-
20875869Association between polymorphisms of TP53 and MDM2 and prostate cancer risk in southern Chinese.Cancer Genet Cytogenet2010 Oct 15Xu Bdoi: 10.1016/j.cancergencyto.2010.02.014.
23624782Association of MDM2 SNP309 and TP53 Arg72Pro polymorphisms with risk of endometrial cancer.Oncol Rep2013 JulYoneda Tdoi: 10.3892/or.2013.2433
24870800A functional SNP in the MDM2 promoter mediates E2F1 affinity to modulate cyclin D1 expression in tumor cell proliferation.Asian Pac J Cancer Prev2014Yang ZH-
22744426Polymorphisms in TP53 and MDM2 contribute to higher risk of colorectal cancer in Chinese population: a hospital-based, case-control study.Mol Biol Rep2012 OctZhang Ydoi: 10.1007/s11033-012-1831-5
21479369Involvement of p53 R72P polymorphism in the association of MDM2-SNP309 with breast cancer.Oncol Rep2011 JunLeu JDdoi: 10.3892/or.2011.1254
16434608No association between the MDM2 -309 T/G promoter polymorphism and breast cancer in African-Americans or Whites.Cancer Epidemiol Biomarkers Prev2006 JanMillikan RC-
19062713[Impact of PI3K /Akt /mdm2 signaling pathway on the sensitivity of gastric cancer cell line SGC7901 to doxorubicin].Zhonghua Zhong Liu Za Zhi2008 JulAi YW-
18317451Protein kinase C epsilon confers resistance of MCF-7 cells to TRAIL by Akt-dependent activation of Hdm2 and downregulation of p53.Oncogene2008 Jun 26Shankar Edoi: 10.1038/onc.2008.39
23870475Expression and significance of p53 and mdm2 in patients with leukoplakia cancer.Asian Pac J Trop Med2013 OctCui JJdoi: 10.1016/S1995-7645(13)60147-9.
17620186P53 and MDM2 isoforms in blood from lung cancer patients.Exp Lung Res2007 Jun-JulGonzalez-Avila G-
26281353[Multifunctionality of MDM2 protein and its role in genomic instability of cancer cells].Postepy Biochem2015Maluszek M-
26625797Correlation between Patterns of Mdm2 SNIP 309 and Histopathological Severity of Helicobacter pylori Associated Gastritis in Thailand.Asian Pac J Cancer Prev2015Tongtawee T-
25672611Association of p53 and mdm2 in the development and progression of non-small cell lung cancer.Tumour Biol2015 JulJavid Jdoi: 10.1007/s13277-015-3208-6
24293392MDM2 rs2279744 polymorphism and endometrial cancer: a meta-analysis.Tumour Biol2014 AprWang LHdoi: 10.1007/s13277-013-1413-8
18519798A novel functional polymorphism C1797G in the MDM2 promoter is associated with risk of bladder cancer in a Chinese population.Clin Cancer Res2008 Jun 1Wang Mdoi: 10.1158/1078-0432.CCR-07-5155.
17538168MDM2 polymorphism, survival, and histology in early-stage non-small-cell lung cancer.J Clin Oncol2007 Jun 1Heist RS-
21478269Functional inactivation of endogenous MDM2 and CHIP by HSP90 causes aberrant stabilization of mutant p53 in human cancer cells.Mol Cancer Res2011 MayLi Ddoi: 10.1158/1541-7786.MCR-10-0534
19470936MDM2 and Ki-67 predict for distant metastasis and mortality in men treated with radiotherapy and androgen deprivation for prostate cancer: RTOG 92-02.J Clin Oncol2009 Jul 1Khor LYdoi: 10.1200/JCO.2008.19.8267
23451111MDM2 SNP309 rs2279744 polymorphism and gastric cancer risk: a meta-analysis.PLoS One2013Ma Ydoi: 10.1371/journal.pone.0056918
25227851Effects of p53 codon 72 and MDM2 SNP309 polymorphisms on gastric cancer risk among the Iranian population.Asian Pac J Cancer Prev2014Moradi MT-
19751436Interaction of Helicobacter pylori with genetic variants in the MDM2 promoter, is associated with gastric cancer susceptibility in Chinese patients.Helicobacter2009 OctWang Xdoi: 10.1111/j.1523-5378.2009.00712.x.
19526525MDM2 SNP309 genotype influences survival of metastatic but not of localized neuroblastoma.Pediatr Blood Cancer2009 OctPerfumo Cdoi: 10.1002/pbc.22132.
16152608Genetic variants in the MDM2 promoter and lung cancer risk in a Chinese population.Int J Cancer2006 Mar 1Hu Z-
18313915MDM2 SNP309 G allele decreases risk but does not affect onset age or survival of Chinese leukaemia patients.Eur J Cancer2008 MarPhang BHdoi: 10.1016/j.ejca.2008.02.007
11859876Overexpression of MDM2 oncoprotein correlates with possession of estrogen receptor alpha and lack of MDM2 mRNA splice variants in human breast cancer.Breast Cancer Res Treat2002 JanHori M-
22310835Possible implication of Mdm2 as a prognostic marker in invasive laryngeal carcinoma.Eur Arch Otorhinolaryngol2012 JulHassumi-Fukasawa MKdoi: 10.1007/s00405-012-1937-3
22558411MDM2 promoter SNP344T>A (rs1196333) status does not affect cancer risk.PLoS One2012Knappskog Sdoi: 10.1371/journal.pone.0036263
20822933Are cell cycle and apoptosis genes associated with prostate cancer risk in North Indian population?Urol Oncol2012 SepMandal RKdoi: 10.1016/j.urolonc.2010.05.006
21867960MDM2 SNP309 contributes to tumor susceptibility: a meta-analysis.J Genet Genomics2011 Aug 20Wo Xdoi: 10.1016/j.jgg.2011.07.005
18953830[Genetic polymorphism in MDM2 is associated with susceptibility to colorectal cancer in a Chinese population].Zhonghua Zhong Liu Za Zhi2008 MayLiu JN-
19707196The TP53 Arg72Pro and MDM2 309G>T polymorphisms are not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers.Br J Cancer2009 Oct 20Sinilnikova OMdoi: 10.1038/sj.bjc.6605279
12750288p53-independent activation of the hdm2-P2 promoter through multiple transcription factor response elements results in elevated hdm2 expression in estrogen receptor alpha-positive breast cancer cells.Cancer Res2003 May 15Phelps M-
16883576A downstream kinase of the mammalian target of rapamycin, p70S6K1, regulates human double minute 2 protein phosphorylation and stability.J Cell Physiol2006 NovFang J-
22938470Association between MDM2 promoter SNP309 T/G polymorphism and liver cancer risk - a meta-analysis.Asian Pac J Cancer Prev2012Ma HB-
27569097MDM2 344T>A polymorphism; could it be a predictive marker of anthracycline resistance?J BUON2016 May-JunArfaoui A-
17638920Interaction of P53 Arg72Pro and MDM2 T309G polymorphisms and their associations with risk of gastric cardia cancer.Carcinogenesis2007 SepYang M-
21539745MDM2 antagonists boost antitumor effect of androgen withdrawal: implications for therapy of prostate cancer.Mol Cancer2011 May 3Tovar Cdoi: 10.1186/1476-4598-10-49.
16478747Association between MDM2-SNP309 and age at colorectal cancer diagnosis according to p53 mutation status.J Natl Cancer Inst2006 Feb 15Menin C-
17719241Association of polymorphism in MDM-2 and p53 genes with breast cancer risk in Indian women.Ann Epidemiol2008 JanSingh V-
25110100Mathematical simulation of p53-Mdm2 protein biological system regulation.Bull Exp Biol Med2014 AugVoropaeva OFdoi: 10.1007/s10517-014-2608-8
25241153Study of MDM2 and SUMO-1 expression in actinic cheilitis and lip cancer.Arch Dermatol Res2014 NovOliveira Alves MGdoi: 10.1007/s00403-014-1500-8
25070969MDM2 oncogene, E3 ubiquitin protein ligase T309G polymorphism and risk of oesophageal or gastric cancer: meta-analysis of 15 studies.J Int Med Res2014 OctShen Wdoi: 10.1177/0300060514527910
21770737MDM2 SNP309 polymorphism and colorectal cancer risk: a meta-analysis.DNA Cell Biol2012 MarCao Xdoi: 10.1089/dna.2011.1338
19020940Polymorphisms of p16, p27, p73, and MDM2 modulate response and survival of pancreatic cancer patients treated with preoperative chemoradiation.Ann Surg Oncol2009 FebChen Jdoi: 10.1245/s10434-008-0220-8
17909070Do MDM2 SNP309 and TP53 R72P interact in breast cancer susceptibility? A large pooled series from the breast cancer association consortium.Cancer Res2007 Oct 1Schmidt MK-
25316267TP53 and MDM2 polymorphisms and the risk of endometrial cancer in postmenopausal women.Med Oncol2014 NovZajac Adoi: 10.1007/s12032-014-0286-z
17013834Combined effects of p73 and MDM2 polymorphisms on the risk of lung cancer.Mol Carcinog2007 FebJun HJ-
23679294Association between MDM2 SNP309 T>G and risk of gastric cancer: a meta-analysis.Asian Pac J Cancer Prev2013Tian X-
24823443HAUSP, a novel deubiquitinase for Rb - MDM2 the critical regulator.FEBS J2014 JulBhattacharya Sdoi: 10.1111/febs.12843
26977010MDM2 and PSMA Play Inhibitory Roles in Metastatic Breast Cancer Cells Through Regulation of Matrix Metalloproteinases.Anticancer Res2016 MarBradbury R-
18292944CARF (collaborator of ARF) interacts with HDM2: evidence for a novel regulatory feedback regulation of CARF-p53-HDM2-p21WAF1 pathway.Int J Oncol2008 MarHasan MK-
21547352MDM2 SNP309 is associated with endometrial cancer susceptibility: a meta-analysis.Hum Cell2011 JunLi Ydoi: 10.1007/s13577-011-0013-4
19941740Frequency and prognostic significance of murine double minute protein-2 overexpression and p53 gene mutations in childhood acute lymphoblastic leukemia.Hematology2009 DecHendy OMdoi: 10.1179/102453309X12473408860389.
22487911MDM2 SNP285 does not antagonize the effect of SNP309 in lung cancer.Int J Cancer2012 Dec 1Ryan BMdoi: 10.1002/ijc.27573
26320449MDM2 and TP53 Polymorphisms as Predictive Markers for Head and Neck Cancer in Northeast Indian Population: Effect of Gene-Gene and Gene-Environment Interactions.Asian Pac J Cancer Prev2015Bhowmik A-
21706156MDM2 SNP309 and TP53 R72P associated with severe and febrile neutropenia in breast cancer patients treated with 5-FU/epirubicin/cyclophosphamide.Breast Cancer Res Treat2012 AprOkishiro Mdoi: 10.1007/s10549-011-1637-5
19411066Regulation of XIAP translation and induction by MDM2 following irradiation.Cancer Cell2009 May 5Gu Ldoi: 10.1016/j.ccr.2009.03.002.
18234963TAp73 alpha increases p53 tumor suppressor activity in thyroid cancer cells via the inhibition of Mdm2-mediated degradation.Mol Cancer Res2008 JanMalaguarnera Rdoi: 10.1158/1541-7786.MCR-07-0005.
19346994Clinicopathological correlations of cyclooxygenase-2, MDM2, and p53 expressions in surgically resectable pancreatic invasive ductal adenocarcinoma.Pancreas2009 JulHermanova Mdoi: 10.1097/MPA.0b013e31819fef8b.
21725850MDM2 SNP309 polymorphism and breast cancer risk: a meta-analysis.Mol Biol Rep2012 AprZhao Edoi: 10.1007/s11033-011-1119-1
21080085MDM2 is overexpressed and regulated by the eukaryotic translation initiation factor 4E (eIF4E) in human squamous cell carcinoma of esophagus.Ann Surg Oncol2011 MayHsu HSdoi: 10.1245/s10434-010-1428-y
25074979MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer.Sci Signal2014 Jul 29Thirumurthi Udoi: 10.1126/scisignal.2005076.
19193430Polymorphisms in TP53 and MDM2 combined are associated with high grade endometrial cancer.Gynecol Oncol2009 AprAshton KAdoi: 10.1016/j.ygyno.2008.12.036
23423487Effect of TP53 codon 72 and MDM2 SNP309 polymorphisms on survival of gastric cancer among patients who receiving 5-fluorouracil-based postoperative adjuvant chemotherapy.Cancer Chemother Pharmacol2013 AprWang Sdoi: 10.1007/s00280-013-2103-3
18804411MDM2 SNP309 does not confer an increased risk to oral squamous cell carcinoma but may modulate the age of disease onset.Oral Oncol2009 JunHamid Sdoi: 10.1016/j.oraloncology.2008.06.003
24289472The clinicopathological significance and relationship of Gli1, MDM2 and p53 expression in resectable pancreatic cancer.Histopathology2014 MarSheng Wdoi: 10.1111/his.12273
18828900MDM2 SNP309 is associated with high grade node positive breast tumours and is in linkage disequilibrium with a novel MDM2 intron 1 polymorphism.BMC Cancer2008 Oct 1Paulin FEdoi: 10.1186/1471-2407-8-281.
19264476MDM2 309 T/G polymorphism is associated with lung cancer risk among Asians.Eur J Cancer2009 JulGui XHdoi: 10.1016/j.ejca.2009.02.002
14522887Tumor promotion by Mdm2 splice variants unable to bind p53.Cancer Res2003 Sep 15Fridman JS-
21229604Role of the MDM2 SNP309 polymorphism in the initiation and early age of onset of nasopharyngeal carcinoma.Mol Carcinog2011 FebSousa Hdoi: 10.1002/mc.20689
18348658No association of MDM2 T309G polymorphism with susceptibility to Korean gastric cancer patients.Neoplasma2008Cho YG-
22844496Association of MDM2 SNP309 variation with lung cancer risk: evidence from 7196 cases and 8456 controls.PLoS One2012Zhuo Wdoi: 10.1371/journal.pone.0041546
21051533TP53 R72P and MDM2 SNP309 polymorphisms and colorectal cancer risk: the Fukuoka Colorectal Cancer Study.Jpn J Clin Oncol2011 FebJoshi AMdoi: 10.1093/jjco/hyq200
24844868Current evidence on the relationship between murine double minute 2 T309G polymorphism and esophageal cancer susceptibility.Dis Esophagus2015 Aug-SepChen Bdoi: 10.1111/dote.12240
26151241Overexpression of microRNA125a3p effectively inhibits the cell growth and invasion of lung cancer cells by regulating the mouse double minute 2 homolog/p53 signaling pathway.Mol Med Rep2015 OctLi Sdoi: 10.3892/mmr.2015.4038
16287156Genetic polymorphisms in cell cycle regulatory genes MDM2 and TP53 are associated with susceptibility to lung cancer.Hum Mutat2006 JanZhang X-
26840028microRNA-1827 represses MDM2 to positively regulate tumor suppressor p53 and suppress tumorigenesis.Oncotarget2016 Feb 23Zhang Cdoi: 10.18632/oncotarget.7088.
26373042Polymorphisms in NEIL-2, APE-1, CYP2E1 and MDM2 Genes are Independent Predictors of Gastric Cancer Risk in a Northern Jiangsu Population (China).J Nanosci Nanotechnol2015 JulElingarami S-
27015167Murine Double Minute 2 SNP T309G Polymorphism and Urinary Tract Cancer Risk: A Meta-Analysis.Medicine (Baltimore)2016 MarDing Hdoi: 10.1097/MD.0000000000002941.
17116689Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation.Mol Cell Biol2007 FebLindstrom MS-
22914606Relationship between MDM2 and p53 alterations in colorectal cancer and their involvement and prognostic value in the Tunisian population.Appl Immunohistochem Mol Morphol2013 MayChaar Idoi: 10.1097/PAI.0b013e31825f4e20.
18547962MDM2SNP309 does not associate with elevated MDM2 protein expression or breast cancer risk.Oncology2008Krekac Ddoi: 10.1159/000139135
19671680MDM2 controls the timely expression of cyclin A to regulate the cell cycle.Mol Cancer Res2009 AugFrum Rdoi: 10.1158/1541-7786.MCR-08-0334
17003841The single-nucleotide polymorphism 309 in the MDM2 gene contributes to the Li-Fraumeni syndrome and related phenotypes.Eur J Hum Genet2007 JanRuijs MW-
11894120Antisense anti-MDM2 mixed-backbone oligonucleotides enhance therapeutic efficacy of topoisomerase I inhibitor irinotecan in nude mice bearing human cancer xenografts: In vivo activity and mechanisms.Int J Oncol2002 AprWang H-
18355939EGFR, TTF-1 and Mdm2 expression in stage III non-small cell lung cancer: a positive association.Lung Cancer2008 OctBerghmans Tdoi: 10.1016/j.lungcan.2008.02.003
19955655TGF-beta1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer.J Clin Invest2010 JanAraki Sdoi: 10.1172/JCI39194
25271042Effects of MDM2 promoter polymorphisms on the development of cervical neoplasia in a Southeastern Brazilian population.Biomarkers2014 DecVargas-Torres SLdoi: 10.3109/1354750X.2014.962614
20080680Anticancer peptide PNC-27 adopts an HDM-2-binding conformation and kills cancer cells by binding to HDM-2 in their membranes.Proc Natl Acad Sci U S A2010 Feb 2Sarafraz-Yazdi Edoi: 10.1073/pnas.0909364107
24377582Meta-analysis of the MDM2 T309G polymorphism and gastric cancer risk.Asian Pac J Cancer Prev2014 JanSong B-
19764997Association of TP53 and MDM2 polymorphisms with survival in bladder cancer patients treated with chemoradiotherapy.Cancer Sci2009 DecShinohara Adoi: 10.1111/j.1349-7006.2009.01331.x
25016295Identification of a new class of MDM2 inhibitor that inhibits growth of orthotopic pancreatic tumors in mice.Gastroenterology2014 OctWang Wdoi: 10.1053/j.gastro.2014.07.001
25122426DNMT3B overexpression by deregulation of FOXO3a-mediated transcription repression and MDM2 overexpression in lung cancer.J Thorac Oncol2014 SepYang YCdoi: 10.1097/JTO.0000000000000240.
16203772p53 codon 72 and MDM2 SNP309 polymorphisms and age of colorectal cancer onset in Lynch syndrome.Clin Cancer Res2005 Oct 1Sotamaa K-
20219101Effect of MDM2 SNP309 and p53 codon 72 polymorphisms on lung cancer risk and survival among non-smoking Chinese women in Singapore.BMC Cancer2010 Mar 10Chua HWdoi: 10.1186/1471-2407-10-88.
14729628p53 activation in chronic radiation-treated breast cancer cells: regulation of MDM2/p14ARF.Cancer Res2004 Jan 1Xia L-
17717065Reduced Mcm2 expression results in severe stem/progenitor cell deficiency and cancer.Stem Cells2007 DecPruitt SC-
12450795Transformation of normal human cells in the absence of telomerase activation.Cancer Cell2002 NovSeger YR-
17387621The p53 Arg72Pro and MDM2 -309 polymorphisms and risk of breast cancer in the nurses' health studies.Cancer Causes Control2007 AugCox DG-
26514489Genetic Polymorphism of MDM2 SNP309 in Patients with Helicobacter Pylori-Associated Gastritis.Asian Pac J Cancer Prev2015Tongtawee T-
17545525A polymorphism in HDM2 (SNP309) associates with early onset in superficial tumors, TP53 mutations, and poor outcome in invasive bladder cancer.Clin Cancer Res2007 Jun 1Sanchez-Carbayo M-
19509552Association of p73 and MDM2 polymorphisms with the risk of epithelial ovarian cancer in Chinese women.Int J Gynecol Cancer2009 MayKang Sdoi: 10.1111/IGC.0b013e3181a130ab.
25842826[Association of polymorphic markers Arg72Pro of TP53 and T309g of MDM2 genes with non small cell lung cancer in Russians of Moscow region].Mol Biol (Mosk)2014 Jan-FebLoginov VI-
25280518Triptolide induces apoptosis of gastric cancer cells via inhibiting the overexpression of MDM2.Med Oncol2014 NovWang BYdoi: 10.1007/s12032-014-0270-7
25537146TP53 Arg 72Pro and MDM2 SNP309 polymorphisms and colorectal cancer risk: a west Algerian population study.Pathol Oncol Res2015 JulAbderrahmane Rdoi: 10.1007/s12253-014-9867-6
21268124MDM2 SNP309 contributes to non-small cell lung cancer survival in Chinese.Mol Carcinog2011 JunDong Jdoi: 10.1002/mc.20727
19448627p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug.Nat Cell Biol2009 JunWang SPdoi: 10.1038/ncb1875
25649770Interaction between p53 mutation and a somatic HDMX biomarker better defines metastatic potential in breast cancer.Cancer Res2015 Feb 15Grawenda AMdoi: 10.1158/0008-5472.CAN-14-2637
24792886Common variant on MDM2 contributes to endometrial cancer susceptibility: evidence based on 7 studies.Tumour Biol2014 AugZhao Ydoi: 10.1007/s13277-014-1886-0
20832750A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development.Cancer Cell2010 Sep 14Post SMdoi: 10.1016/j.ccr.2010.07.010.
19874399Polymorphisms of p53 codon 72 and MDM2 promoter 309 and the risk of endometrial cancer.Hum Cell2009 NovNunobiki Odoi: 10.1111/j.1749-0774.2009.00075.x.
25119589Association between murine double minute 2 T309G polymorphism and risk of liver cancer.Tumour Biol2014 NovTang Tdoi: 10.1007/s13277-014-2432-9
27825169Inhibition of MDM2 Re-Sensitizes Rapamycin Resistant Renal Cancer Cells via the Activation of p53.Cell Physiol Biochem2016Tian X-
24532430MDM2 SNP309 variation increases cervical cancer risk among Asians.Tumour Biol2014 JunZhuo Xdoi: 10.1007/s13277-014-1695-5
19029954Hdm2 is regulated by K-Ras and mediates p53-independent functions in pancreatic cancer cells.Oncogene2009 Feb 5Sui Xdoi: 10.1038/onc.2008.423
15492852Alteration of the MDM2-p73-P14ARF pathway related to tumour progression during urinary bladder carcinogenesis.Int J Mol Med2004 NovSchlott T-
22467100Murine double minute clone 2,309T/G and 285G/C promoter single nucleotide polymorphism as a risk factor for breast cancer: a Polish experience.Int J Biol Markers2012 Jul 19Piotrowski Pdoi: 10.5301/JBM.2012.9140.
23383041The MDM2 309T>G polymorphism and ovarian cancer risk: a meta-analysis of 1534 cases and 2211 controls.PLoS One2013Ma YYdoi: 10.1371/journal.pone.0055019
23881403Cooperation among Numb, MDM2 and p53 in the development and progression of pancreatic cancer.Cell Tissue Res2013 NovSheng Wdoi: 10.1007/s00441-013-1679-6
20855462Single-nucleotide polymorphisms in p53 pathway and aggressiveness of prostate cancer in a Caucasian population.Clin Cancer Res2010 Nov 1Sun Tdoi: 10.1158/1078-0432.CCR-10-1261
11956627Distinct promoter usage of mdm2 gene in human breast cancer.Oncol Rep2002 May-JunOkumura N-
19523862No evidence for association of the MDM2-309 T/G promoter polymorphism with prostate cancer outcomes.Urol Oncol2011 May-JunJaboin JJdoi: 10.1016/j.urolonc.2009.03.031
19945467Downregulation of p53 by phosphatase of regenerating liver 3 is mediated by MDM2 and PIRH2.Life Sci2010 Jan 2Min SHdoi: 10.1016/j.lfs.2009.11.010
24098760An updated meta-analysis on the association of MDM2 SNP309 polymorphism with colorectal cancer risk.PLoS One2013 Sep 30Qin Xdoi: 10.1371/journal.pone.0076031
19639206The significance of MDM2 SNP309 and p53 Arg72Pro in young women with breast cancer.Oncol Rep2009 SepLang A-
24292333Subcellular localization of Mdm2 expression and prognosis of breast cancer.Int J Clin Oncol2014 OctPark HSdoi: 10.1007/s10147-013-0639-1
15714438Alternative splicing of MDM2 mRNA in lung carcinomas and lung cell lines.Environ Mol Mutagen2005 JulWeng MW-
26317544KMT Set7/9 affects genotoxic stress response via the Mdm2 axis.Oncotarget2015 Sep 22Lezina Ldoi: 10.18632/oncotarget.4584.
27890964Association of the MDM2 SNP285 Polymorphism with Cancer Susceptibility: A Meta-Analysis.Dis Markers2016Wang P-
22330136Loss of microRNA-143/145 disturbs cellular growth and apoptosis of human epithelial cancers by impairing the MDM2-p53 feedback loop.Oncogene2013 Jan 3Zhang Jdoi: 10.1038/onc.2012.28
21504894MDM2 interacts with NME2 (non-metastatic cells 2, protein) and suppresses the ability of NME2 to negatively regulate cell motility.Carcinogenesis2011 AugPolanski Rdoi: 10.1093/carcin/bgr070
21602883Aging mice have increased chromosome instability that is exacerbated by elevated Mdm2 expression.Oncogene2011 Nov 17Lushnikova Tdoi: 10.1038/onc.2011.172
25040988The MDM2 SNP309T>G polymorphism increases bladder cancer risk among Caucasians: a meta-analysis.Asian Pac J Cancer Prev2014Wang HG-
20200430TP53, MDM2, NQO1, and susceptibility to cervical cancer.Cancer Epidemiol Biomarkers Prev2010 MarHu Xdoi: 10.1158/1055-9965.EPI-09-0886
20021639Combined effects of single nucleotide polymorphisms TP53 R72P and MDM2 SNP309, and p53 expression on survival of breast cancer patients.Breast Cancer Res2009Schmidt MKdoi: 10.1186/bcr2460
23039163Effect of the MDM2 promoter polymorphisms SNP309T>G and SNP285G>C on the risk of ovarian cancer in BRCA1 mutation carriers.BMC Cancer2012 Oct 5Bjornslett Mdoi: 10.1186/1471-2407-12-454.
19941079Associations of MDM2 SNP309, transcriptional activity, mRNA expression, and survival in stage I non-small-cell lung cancer patients with wild-type p53 tumors.Ann Surg Oncol2010 AprChien WPdoi: 10.1245/s10434-009-0853-2
23167337Meta-analysis of associations between the MDM2-T309G polymorphism and prostate cancer risk.Asian Pac J Cancer Prev2012Chen T-
25001177Netrin-1 promoted pancreatic cancer cell proliferation by upregulation of Mdm2.Tumour Biol2014 OctHuang Qdoi: 10.1007/s13277-014-2195-3
25201204Lung cancer stem cells, p53 mutations and MDM2.Subcell Biochem2014Gadepalli VSdoi: 10.1007/978-94-017-9211-0_19.
24147044Endogenous human MDM2-C is highly expressed in human cancers and functions as a p53-independent growth activator.PLoS One2013 Oct 11Okoro DRdoi: 10.1371/journal.pone.0077643
22349818Coordinate regulation of estrogen receptor β degradation by Mdm2 and CREB-binding protein in response to growth signals.Oncogene2013 Jan 3Sanchez Mdoi: 10.1038/onc.2012.19
27798881Expression of the p53 Inhibitors MDM2 and MDM4 as Outcome Predictor in Muscle-invasive Bladder Cancer.Anticancer Res2016 OctKriegmair MC-
25637791Heat shock protein gp96 decreases p53 stability by regulating Mdm2 E3 ligase activity in liver cancer.Cancer Lett2015 Apr 10Wu Bdoi: 10.1016/j.canlet.2015.01.034
25327560Population distribution and ancestry of the cancer protective MDM2 SNP285 (rs117039649).Oncotarget2014 Sep 30Knappskog S-
27604213Relationship Between Murine Double Minute 2 (MDM2) T309G Polymorphism and Endometrial Cancer Risk: A Meta-Analysis.Med Sci Monit2016 Sep 8Xue Z-
28406480WDR79 promotes the proliferation of non-small cell lung cancer cells via USP7-mediated regulation of the Mdm2-p53 pathway.Cell Death Dis2017 Apr 13Sun Ydoi: 10.1038/cddis.2017.162.
276934582-Methoxy-5((3,4,5-trimethosyphenyl)seleninyl) phenol inhibits MDM2 and induces apoptosis in breast cancer cells through a p53-independent pathway.Cancer Lett2016 Dec 1Xu Jdoi: 10.1016/j.canlet.2016.09.011
27130667Long non-coding RNA LOC572558 inhibits bladder cancer cell proliferation and tumor growth by regulating the AKT-MDM2-p53 signaling axis.Cancer Lett2016 Oct 1Zhu Ydoi: 10.1016/j.canlet.2016.04.030
27617579FKBP12 enhances sensitivity to chemotherapy-induced cancer cell apoptosis by inhibiting MDM2.Oncogene2017 Mar 23Liu Tdoi: 10.1038/onc.2016.331
26956143Evaluation of TP53 Pro72Arg and MDM2 SNP285-SNP309 polymorphisms in an Italian cohort of LFS suggestive patients lacking identifiable TP53 germline mutations.Fam Cancer2016 OctPonti Fdoi: 10.1007/s10689-016-9895-3.
28817834MDM2 promotes epithelial-mesenchymal transition and metastasis of ovarian cancer SKOV3 cells.Br J Cancer2017 Oct 10Chen Ydoi: 10.1038/bjc.2017.265
27957778Assessment of TP53 Polymorphisms and MDM2 SNP309 in Premenopausal Breast Cancer Risk.Hum Mutat2017 MarSamuel Ndoi: 10.1002/humu.23154
29175211Nutlin sensitizes lung carcinoma cells to interferon-alpha treatment in MDM2-dependent but p53-independent manner.Biochem Biophys Res Commun2018 Jan 1Shuvalov Odoi: 10.1016/j.bbrc.2017.11.118
26025918MDM2 and P53 polymorphisms contribute together to the risk and survival of prostate cancer.Oncotarget2016 May 31Xue Ldoi: 10.18632/oncotarget.3923.
27184007Mouse double minute 2 (MDM2) upregulates Snail expression and induces epithelial-to-mesenchymal transition in breast cancer cells in vitro and in vivo.Oncotarget2016 Jun 14Lu Xdoi: 10.18632/oncotarget.9287.
27259273MDM2 knockdown mediated by a triazine-modified dendrimer in the treatment of non-small cell lung cancer.Oncotarget2016 Jul 12Huang Qdoi: 10.18632/oncotarget.9768.
27081698Associations between the MDM2 promoter P1 polymorphism del1518 (rs3730485) and incidence of cancer of the breast, lung, colon and prostate.Oncotarget2016 May 10Gansmo LBdoi: 10.18632/oncotarget.8705.
26993775PIM1 destabilization activates a p53-dependent response to ribosomal stress in cancer cells.Oncotarget2016 Apr 26Sagar Vdoi: 10.18632/oncotarget.8070.
27004407Triptolide has anticancer and chemosensitization effects by down-regulating Akt activation through the MDM2/REST pathway in human breast cancer.Oncotarget2016 Apr 26Xiong Jdoi: 10.18632/oncotarget.8207.
28418896NFkB is essential for activin-induced colorectal cancer migration via upregulation of PI3K-MDM2 pathway.Oncotarget2017 Jun 6Jana Adoi: 10.18632/oncotarget.16343.
28567715MDMX is a prognostic factor for non-small cell lung cancer and regulates its sensitivity to cisplatin.Cell Oncol (Dordr)2017 AugZhao Hdoi: 10.1007/s13402-017-0325-9
29096752The association between murine double minute 2 (MDM2) rs2279744 and endometrial cancer risk in a Chinese Han population.Cell Mol Biol (Noisy-le-grand)2017 Oct 31Wu JPdoi: 10.14715/cmb/2017.63.10.20.
29699057Significant Association of the MDM2 T309G Polymorphism with Breast Cancer Risk in a Turkish PopulationAsian Pac J Cancer Prev2018 Apr 27Yilmaz M-
28800790miR-641 Functions as a Tumor Suppressor by Targeting MDM2 in Human Lung Cancer.Oncol Res2018 Jun 11Kong Qdoi: 10.3727/096504017X15021536183490
29734849Antiproliferative and apoptosis-induction studies of 5-hydroxy 3',4',7-trimethoxyflavone in human breast cancer cells MCF-7: an in vitro and in silico approach.J Recept Signal Transduct Res2018 JunSudha Adoi: 10.1080/10799893.2018.1468780
29777315The MDM2 rs937283 A>G variant significantly increases the risk of lung and gastric cancer in Chinese population.Int J Clin Oncol2018 OctChen Bdoi: 10.1007/s10147-018-1295-2
30194081Contribution of Murine Double Minute 2 Genotypes to Colorectal Cancer Risk in Taiwan.Cancer Genomics Proteomics2018 Sep-OctYueh TCdoi: 10.21873/cgp.20099.
29755129Molecular mechanism of the TP53-MDM2-AR-AKT signalling network regulation by USP12.Oncogene2018 AugMcClurg ULdoi: 10.1038/s41388-018-0283-3
26719543IMPORTANCE OF APOPTOSIS MARKERS (MDM2, BCL-2 AND Bax) IN BENIGN PROSTATIC HYPERPLASIA AND PROSTATE CANCER.Georgian Med News2015 DecSaker Z-

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr1268839643Missense_MutationnovelE430Q0.49
ACCchr1268816848Nonsense_MutationnovelR71*0.33
BLCAchr1268824392Missense_MutationnovelE130K0.05
BLCAchr1268813586SilentNAL44L0.35
BLCAchr1268835968Nonsense_MutationnovelS275*0.08
BLCAchr1268839844Missense_MutationnovelP497A0.39
BLCAchr1268835881Missense_MutationnovelS246L0.33
BRCAchr1268839349Missense_Mutationrs773519801R332C0.1
BRCAchr1268836723Missense_MutationnovelE298K0.16
BRCAchr1268808481Missense_MutationNAV2L0.87
CESCchr1268816908Missense_MutationNAL91V0.32
CESCchr12688082685'UTRnovel0.22
CESCchr12688082905'UTRnovel0.23
COADchr1268828877Missense_MutationNAE210D0.4
COADchr1268839725Missense_MutationNAV457A0.38
COADchr1268835925Missense_Mutationrs549965230D261N0.08
COADchr1268839393Missense_MutationNAE346D0.32
COADchr1268839838Missense_MutationNAY495H0.24
COADchr1268839382Missense_MutationNAD343N0.27
COADchr1268836745Frame_Shift_InsnovelL305Ffs*160.09
COADchr12688084475'UTRnovel0.29
ESCAchr1268839764Missense_MutationNAC470Y0.22
ESCAchr12688084725'UTRnovel0.21
ESCAchr1268835876SilentnovelQ244Q0.13
GBMchr1268824384Missense_MutationnovelS127F0.43
GBMchr1268836740Missense_MutationnovelI303M0.05
GBMchr1268839396SilentnovelI347I0.09
HNSCchr1268835920Missense_MutationnovelS259Y0.42
HNSCchr1268839691Missense_MutationnovelI446V0.07
HNSCchr1268809245Missense_MutationnovelG18R0.35
KIRCchr1268836739Splice_SitenovelX303_splice0.08
LGGchr1268828867Missense_MutationnovelV207E0.47
LGGchr1268816889SilentnovelS84S0.42
LGGchr1268816916Silentrs764994410G93G0.42
LGGchr1268836741Missense_Mutationrs755429424S304P0.38
LIHCchr1268839303Missense_Mutationrs778582378E316D0.48
LIHCchr1268813586SilentNAL44L0.06
LUADchr1268839616Missense_MutationNAE421Q0.33
LUADchr12688398523'UTRnovel0.21
LUADchr1268824362Splice_SiteNAX120_splice0.3
LUADchr1268816893Missense_MutationNAD86Y0.5
LUADchr1268824586Missense_MutationnovelP153H0.3
LUADchr1268824552Splice_Regionnovel0.22
LUADchr1268836699Missense_MutationnovelG290W0.06
LUSCchr1268824406Frame_Shift_DelnovelH134Qfs*730.38
LUSCchr1268824565Missense_MutationNAQ146P0.26
LUSCchr1268839694Missense_MutationNAC447S0.12
LUSCchr1268839553Frame_Shift_DelnovelY400Ffs*70.08
OVchr1268839690SilentNAV445V0.89
OVchr1268824403SilentnovelC133C0.06
PAADchr1268828900Missense_MutationnovelS218I0.09
PAADchr1268824404Missense_MutationnovelH134D0.15
READchr1268835844Missense_MutationNAV234L0.25
SARCchr1268828879Missense_MutationnovelI211T0.45
SARCchr1268835835Missense_MutationnovelD231N0.12
SARCchr1268835832Missense_MutationnovelL230F0.05
SKCMchr1268813572Missense_MutationnovelL40F0.34zf-RanBP
SKCMchr1268835835Missense_MutationnovelD231N0.19
STADchr1268839397Frame_Shift_DelnovelS348Qfs*170.16
STADchr1268828918Missense_Mutationrs755256189T224M0.32
STADchr1268828918Missense_Mutationrs755256189T224M0.22
STADchr1268809215Missense_MutationNAC8R0.08
STADchr1268839460Frame_Shift_DelnovelT371Lfs*20.11
STADchr1268836684Missense_MutationNAT285P0.17
STADchr12688398593'UTRnovel0.1
STADchr1268839519SilentNAI388I0.18
THCAchr1268839382Frame_Shift_InsnovelD343Vfs*70.04
UCECchr1268828925Silentrs748376263S226S0.35
UCECchr12688399433'UTRnovel0.27
UCECchr1268828925Silentrs748376263S226S0.26
UCECchr1268816849Missense_MutationNAR71Q0.28
UCECchr1268828812Missense_MutationNAR189C0.32
UCECchr1268835946Missense_MutationnovelS268G0.11
UCECchr1268839593Missense_MutationNAS413N0.34
UCECchr1268828925Silentrs748376263S226S0.4
UCECchr12688399693'UTRnovel0.18
UCECchr1268839360Missense_MutationnovelW335C0.31
UCECchr12688400613'UTRnovel0.22
UCECchr1268839816SilentNAP487P0.41
UCECchr12688083105'UTRnovel0.63
UCECchr12688398673'UTRnovel0.23
UCECchr1268839674Missense_MutationnovelA440V0.29
UCECchr1268839310Frame_Shift_DelNAL321Ffs*520.46
UCECchr1268839795SilentnovelP480P0.13
UCECchr1268836721Missense_MutationNAF297S0.41
UCECchr12688084385'UTRnovel0.5
UCECchr12688398743'UTRnovel0.38
UCECchr1268835986Splice_SitenovelX280_splice0.24
UCECchr12688399663'UTRnovel0.25
UCECchr1268835909SilentNAF255F0.15
UCECchr12688399143'UTRnovel0.66
UCECchr1268824370Silentrs376611439S122S0.47
UCECchr1268828868SilentnovelV207V0.41
UCECchr12688398703'UTRnovel0.34
UCECchr1268824634Missense_MutationnovelR169I0.16
UCECchr1268839372SilentnovelD339D0.35
UCECchr1268839717SilentnovelG454G0.36
UCECchr12688399643'UTRnovel0.28
UCECchr1268828924Missense_MutationnovelS226L0.56
UCECchr1268809239Missense_MutationnovelT16A0.46

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.02220.20414
BLCAAMP0.24751.5107e-24
DLBCAMP0.20830.085003
GBMAMP0.14733.9138e-75
HNSCAMP0.13031.2936e-10
LUADAMP0.23644.4652e-18
LUSCAMP0.24350.00092392
PAADAMP0.11410.0061805
READDEL0.09090.064633
SARCAMP0.31911.6311e-75
SKCMAMP0.12269.9717e-11
TGCTAMP0.54670.00041421
UCSAMP0.26790.052337

Survival Analysis
CancerP-value Q-value
ACC0.041

Kaplan-Meier Survival Analysis

PRAD0.033

Kaplan-Meier Survival Analysis

COAD0.039

Kaplan-Meier Survival Analysis

CESC0.0025

Kaplan-Meier Survival Analysis

UCEC0.00011

Kaplan-Meier Survival Analysis

GBM0.04

Kaplan-Meier Survival Analysis

LGG0.0001

Kaplan-Meier Survival Analysis

UVM0.0098

Kaplan-Meier Survival Analysis

Drugs

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Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000135679 (Gene tree)
Gene ID
4193
Gene Symbol
MDM2
Alias
HDM2|MGC5370
Full Name
MDM2 proto-oncogene
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
42,519 bases
Position
chr12:68,808,168-68,850,686
Accession
6973
RBP type
canonical RBP
Summary
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000377062zf-RanBPPF00641.187.2e-0911
ENSP00000377064zf-RanBPPF00641.187.2e-0911
ENSP00000353611zf-RanBPPF00641.189e-0911
ENSP00000299252zf-RanBPPF00641.181e-0811
ENSP00000258148zf-RanBPPF00641.181.5e-0811
ENSP00000266624zf-RanBPPF00641.181.6e-0811
ENSP00000444430zf-RanBPPF00641.181.7e-0811
ENSP00000258149zf-RanBPPF00641.181.7e-0811
ENSP00000335096zf-RanBPPF00641.181.9e-0811
ENSP00000377065zf-RanBPPF00641.185.6e-0811

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
23150764Splicing up mdm2 for cancer proteome diversity.Genes Cancer2012 MarOkoro DRdoi: 10.1177/1947601912455323.
8827714The MDM2 oncoprotein binds specifically to RNA through its RING finger domain.Mol Med1996 JulElenbaas B-
17671681MDM2 RNA binding is blocked by novel monoclonal antibody h-MDM2-F4-14.Int J Oncol2007 SepAnderson JJ-
22108807Recombinant human MDM2 oncoprotein shows sequence composition selectivity for binding to both RNA and DNA.Int J Oncol2012 MarChallen Cdoi: 10.3892/ijo.2011.1267
18257391Mouse and human La proteins differ in kinase substrate activity and activation mechanism for tRNA processing.Gene Expr2007Park JM-
9836595Metal and RNA binding properties of the hdm2 RING finger domain.Biochemistry1998 Dec 1Lai Z-
11925449The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo.J Biol Chem2002 Aug 9Shimizu H-
22103682Specific domains of nucleolin interact with Hdm2 and antagonize Hdm2-mediated p53 ubiquitination.FEBS J2012 FebBhatt Pdoi: 10.1111/j.1742-4658.2011.08430.x
9882094Metal and RNA binding properties of the hdm2 RING finger domain.Biochemistry1998 Dec 1Lai Z-
9278461Proteolytic cleavage of the mdm2 oncoprotein during apoptosis.J Biol Chem1997 Sep 5Chen L-
19106616The p53 mRNA-Mdm2 interaction.Cell Cycle2009 Jan 1Naski N-
21402775Cooperative role of the RNA-binding proteins Hzf and HuR in p53 activation.Mol Cell Biol2011 MayNakamura Hdoi: 10.1128/MCB.01424-10
23150762Concepts in MDM2 Signaling: Allosteric Regulation and Feedback Loops.Genes Cancer2012 MarPonnuswamy Adoi: 10.1177/1947601912454140.
23912475Regulation of Mdm2 mRNA stability by RNA-binding protein RNPC1.Oncotarget2013 AugZhang J-
28274247Gossypol has anti-cancer effects by dual-targeting MDM2 and VEGF in human breast cancer.Breast Cancer Res2017 Mar 9Xiong Jdoi: 10.1186/s13058-017-0818-5.
28984199Roles of alternative splicing in modulating transcriptional regulation.BMC Syst Biol2017 Oct 3Li Jdoi: 10.1186/s12918-017-0465-6.
17226766Concerted activation of the Mdm2 promoter by p72 RNA helicase and the coactivators p300 and P/CAF.J Cell Biochem2007 Aug 1Shin S-
10781812Mdm2 binding to a conformationally sensitive domain on p53 can be modulated by RNA.FEBS Lett2000 Apr 21Burch LR-
17212835Least-squares methods for identifying biochemical regulatory networks from noisy measurements.BMC Bioinformatics2007 Jan 10Kim J-
27317619Peptide-based tumor inhibitor encoding mitochondrial p14(ARF) is highly efficacious to diverse tumors.Cancer Sci2016 SepSaito Kdoi: 10.1111/cas.12991
28837642Hot-spot identification on a broad class of proteins and RNA suggest unifying principles of molecular recognition.PLoS One2017 Aug 24Kulp JL 3rddoi: 10.1371/journal.pone.0183327
9136986Conservation of structural domains and biochemical activities of the MDM2 protein from Xenopus laevis.Oncogene1997 Mar 27Marechal V-
17135243Abrogation of the transactivation activity of p53 by BCCIP down-regulation.J Biol Chem2007 Jan 19Meng X-
21399665The balance between rRNA and ribosomal protein synthesis up- and downregulates the tumour suppressor p53 in mammalian cells.Oncogene2011 Jul 21Donati Gdoi: 10.1038/onc.2011.48
26876197Heterozygous p53(V172F) mutation in cisplatin-resistant human tumor cells promotes MDM4 recruitment and decreases stability and transactivity of p53.Oncogene2016 Sep 8Xie Xdoi: 10.1038/onc.2016.12
23941244Differential gene expression profiles of PPP2R5C-siRNA-treated malignant T cells.DNA Cell Biol2013 OctChen Ydoi: 10.1089/dna.2013.2138
25888903Inhibition of MDM2 homodimerization by XIAP IRES stabilizes MDM2, influencing cancer cell survival.Mol Cancer2015 Mar 26Liu Tdoi: 10.1186/s12943-015-0334-0.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000537182MDM2-2241011-ENSP0000044345078 (aa)-F5H1M7
ENST00000544125MDM2-231649--- (aa)--
ENST00000350057MDM2-2061401XM_006719399ENSP00000266624466 (aa)XP_006719462J3KN53
ENST00000523991MDM2-222505-ENSP00000427828143 (aa)-E7EMW5
ENST00000540709MDM2-227502--- (aa)--
ENST00000543046MDM2-229432--- (aa)--
ENST00000493419MDM2-219577--- (aa)--
ENST00000539479MDM2-2252523XM_005268872ENSP00000444430491 (aa)XP_005268929Q00987
ENST00000393410MDM2-208732-ENSP00000377062243 (aa)-Q9H4C5
ENST00000546048MDM2-234363-ENSP0000044522278 (aa)-F5H1M7
ENST00000481186MDM2-2181056-ENSP0000043111035 (aa)-E5RJQ0
ENST00000393415MDM2-211842-ENSP00000377067256 (aa)-A7UKX8
ENST00000393413MDM2-210657-ENSP00000377065218 (aa)-Q00987
ENST00000393417MDM2-2131683-ENSP0000042902170 (aa)-Q8NDW1
ENST00000393416MDM2-212754-ENSP00000377068229 (aa)-E7EPE2
ENST00000393412MDM2-2091404-ENSP00000377064243 (aa)-Q9H4C5
ENST00000496959MDM2-220897-ENSP0000042969260 (aa)-Q96DS5
ENST00000536089MDM2-2231181-ENSP0000044402878 (aa)-F5H1M7
ENST00000540352MDM2-2261315-ENSP00000445030170 (aa)-F5H4Q8
ENST00000517852MDM2-221393-ENSP00000430257130 (aa)-Q9H4C3
ENST00000544561MDM2-232213-ENSP0000044184170 (aa)-F5GWH7
ENST00000258149MDM2-20212633-ENSP00000258149497 (aa)-Q00987
ENST00000360430MDM2-207891-ENSP00000353611296 (aa)-Q00987
ENST00000545204MDM2-233398-ENSP0000044459751 (aa)-F5GZB0
ENST00000258148MDM2-2011361-ENSP00000258148442 (aa)-G3XA89
ENST00000478070MDM2-217692-ENSP0000043090649 (aa)-E5RHE2
ENST00000311420MDM2-2041583-ENSP0000031074284 (aa)-J3QST1
ENST00000471946MDM2-216251--- (aa)--
ENST00000299252MDM2-203966-ENSP00000299252321 (aa)-Q00987
ENST00000348801MDM2-205798-ENSP00000335096265 (aa)-A0A0C4DFR5
ENST00000400501MDM2-214406--- (aa)--
ENST00000543323MDM2-230427-ENSP00000439238117 (aa)-A0A1B0GXJ6
ENST00000428863MDM2-2151037-ENSP00000410694243 (aa)-Q8TE47
ENST00000542502MDM2-2281127-ENSP0000044456684 (aa)-F5GZC3
Gene Model
Click here to download ENSG00000135679's gene model file
Pathways
Pathway IDPathway NameSource
hsa01522Endocrine resistanceKEGG
hsa01524Platinum drug resistanceKEGG
hsa04068FoxO signaling pathwayKEGG
hsa04110Cell cycleKEGG
hsa04115p53 signaling pathwayKEGG
hsa04120Ubiquitin mediated proteolysisKEGG
hsa04144EndocytosisKEGG
hsa04151PI3K-Akt signaling pathwayKEGG
hsa04218Cellular senescenceKEGG
hsa04625C-type lectin receptor signaling pathwayKEGG
hsa04919Thyroid hormone signaling pathwayKEGG
hsa05163Human cytomegalovirus infectionKEGG
hsa05165Human papillomavirus infectionKEGG
hsa05169Epstein-Barr virus infectionKEGG
hsa05200Pathways in cancerKEGG
hsa05202Transcriptional misregulation in cancerKEGG
hsa05203Viral carcinogenesisKEGG
hsa05205Proteoglycans in cancerKEGG
hsa05206MicroRNAs in cancerKEGG
hsa05214GliomaKEGG
hsa05215Prostate cancerKEGG
hsa05218MelanomaKEGG
hsa05219Bladder cancerKEGG
hsa05220Chronic myeloid leukemiaKEGG
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000135679rs37305901268826856?Mean corpuscular hemoglobin30595370EFO_0004527
ENSG00000135679rs731442101268847050?White blood cell count30595370EFO_0004308
ENSG00000135679rs37305901268826856?Red blood cell count30595370EFO_0004305
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000135679's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000135679MDM210098.901ENSAMEG00000008526MDM29994.929Ailuropoda_melanoleuca
ENSG00000135679MDM29930.285ENSAMEG00000001126MDM47356.977Ailuropoda_melanoleuca
ENSG00000135679MDM29984.211ENSAPLG00000011164MDM29966.870Anas_platyrhynchos
ENSG00000135679MDM29732.106ENSACAG00000007350-9932.724Anolis_carolinensis
ENSG00000135679MDM28875.862ENSACAG00000004204MDM28561.229Anolis_carolinensis
ENSG00000135679MDM29532.677ENSANAG00000036891MDM47355.172Aotus_nancymaae
ENSG00000135679MDM2100100.000ENSANAG00000027171-100100.000Aotus_nancymaae
ENSG00000135679MDM210098.901ENSBTAG00000010422MDM210093.902Bos_taurus
ENSG00000135679MDM29033.333ENSBTAG00000054094-8530.396Bos_taurus
ENSG00000135679MDM29344.615ENSBTAG00000006255MDM49932.094Bos_taurus
ENSG00000135679MDM29270.370ENSCJAG00000040017-10070.370Callithrix_jacchus
ENSG00000135679MDM210098.148ENSCJAG00000007464-8796.095Callithrix_jacchus
ENSG00000135679MDM29532.000ENSCJAG00000016986MDM47053.521Callithrix_jacchus
ENSG00000135679MDM2100100.000ENSCJAG00000042596-9995.494Callithrix_jacchus
ENSG00000135679MDM29532.724ENSCAFG00000009669MDM49632.790Canis_familiaris
ENSG00000135679MDM210098.901ENSCAFG00000000418MDM29492.647Canis_familiaris
ENSG00000135679MDM29132.500ENSCAFG00020005984MDM48031.142Canis_lupus_dingo
ENSG00000135679MDM210098.901ENSCAFG00020017002MDM210093.075Canis_lupus_dingo
ENSG00000135679MDM28947.619ENSCHIG00000010343-7260.000Capra_hircus
ENSG00000135679MDM210098.901ENSCHIG00000019939-10093.890Capra_hircus
ENSG00000135679MDM25330.409ENSCHIG00000027135-5545.652Capra_hircus
ENSG00000135679MDM28989.333ENSTSYG00000031248-9298.214Carlito_syrichta
ENSG00000135679MDM29432.311ENSTSYG00000010731MDM49231.315Carlito_syrichta
ENSG00000135679MDM28458.537ENSCAPG00000011380MDM49632.099Cavia_aperea
ENSG00000135679MDM29532.596ENSCPOG00000008227MDM49632.329Cavia_porcellus
ENSG00000135679MDM210096.154ENSCPOG00000004323MDM29989.796Cavia_porcellus
ENSG00000135679MDM2100100.000ENSCCAG00000006745-10098.148Cebus_capucinus
ENSG00000135679MDM29532.934ENSCCAG00000031000MDM47054.930Cebus_capucinus
ENSG00000135679MDM210093.827ENSCATG00000000265-10097.938Cercocebus_atys
ENSG00000135679MDM2100100.000ENSCATG00000045264-10099.476Cercocebus_atys
ENSG00000135679MDM29432.510ENSCATG00000027086MDM47054.930Cercocebus_atys
ENSG00000135679MDM29432.505ENSCLAG00000011995MDM49231.760Chinchilla_lanigera
ENSG00000135679MDM210094.505ENSCLAG00000009877MDM29890.408Chinchilla_lanigera
ENSG00000135679MDM2100100.000ENSCSAG00000004244MDM210099.185Chlorocebus_sabaeus
ENSG00000135679MDM29432.265ENSCSAG00000014561MDM47054.930Chlorocebus_sabaeus
ENSG00000135679MDM25354.430ENSCHOG00000013096-8650.000Choloepus_hoffmanni
ENSG00000135679MDM29034.799ENSCHOG00000008147-6634.799Choloepus_hoffmanni
ENSG00000135679MDM29487.879ENSCPBG00000013316MDM29969.574Chrysemys_picta_bellii
ENSG00000135679MDM210099.476ENSCANG00000034475MDM210099.476Colobus_angolensis_palliatus
ENSG00000135679MDM29032.491ENSCANG00000032288MDM48031.250Colobus_angolensis_palliatus
ENSG00000135679MDM28051.786ENSCGRG00001004339Mdm47058.571Cricetulus_griseus_chok1gshd
ENSG00000135679MDM210091.304ENSCGRG00001022261Mdm29984.082Cricetulus_griseus_chok1gshd
ENSG00000135679MDM28051.786ENSCGRG00000008463Mdm47058.571Cricetulus_griseus_crigri
ENSG00000135679MDM210091.304ENSCGRG00000017891Mdm29984.490Cricetulus_griseus_crigri
ENSG00000135679MDM210096.154ENSDNOG00000046929-9692.886Dasypus_novemcinctus
ENSG00000135679MDM28846.552ENSDNOG00000000842MDM49233.610Dasypus_novemcinctus
ENSG00000135679MDM210093.548ENSDORG00000007222Mdm29990.566Dipodomys_ordii
ENSG00000135679MDM28257.831ENSDORG00000006873Mdm47154.930Dipodomys_ordii
ENSG00000135679MDM28064.000ENSETEG00000011245MDM47064.000Echinops_telfairi
ENSG00000135679MDM210087.273ENSETEG00000011183MDM29971.805Echinops_telfairi
ENSG00000135679MDM29532.449ENSEASG00005011431MDM47455.682Equus_asinus_asinus
ENSG00000135679MDM210092.308ENSEASG00005008055-10083.707Equus_asinus_asinus
ENSG00000135679MDM29532.449ENSECAG00000004843MDM47455.682Equus_caballus
ENSG00000135679MDM210092.308ENSECAG00000013604MDM210083.707Equus_caballus
ENSG00000135679MDM210092.308ENSEEUG00000013849MDM210081.263Erinaceus_europaeus
ENSG00000135679MDM210038.571ENSEEUG00000013912MDM46249.074Erinaceus_europaeus
ENSG00000135679MDM29638.235ENSELUG00000011889mdm47152.113Esox_lucius
ENSG00000135679MDM210098.901ENSFCAG00000024456MDM210094.705Felis_catus
ENSG00000135679MDM28355.682ENSFCAG00000014851MDM49631.911Felis_catus
ENSG00000135679MDM28158.025ENSFDAG00000021356MDM46854.930Fukomys_damarensis
ENSG00000135679MDM210096.703ENSFDAG00000007913-9890.726Fukomys_damarensis
ENSG00000135679MDM28252.381ENSGMOG00000016389mdm49230.316Gadus_morhua
ENSG00000135679MDM29789.231ENSGALG00000009942MDM29966.734Gallus_gallus
ENSG00000135679MDM210079.348ENSGAGG00000017565-8067.136Gopherus_agassizii
ENSG00000135679MDM29432.510ENSGGOG00000012957MDM47054.930Gorilla_gorilla
ENSG00000135679MDM2100100.000ENSGGOG00000012907MDM2100100.000Gorilla_gorilla
ENSG00000135679MDM29990.909ENSHGLG00000016066-9986.327Heterocephalus_glaber_female
ENSG00000135679MDM210096.703ENSHGLG00000000856-9991.057Heterocephalus_glaber_female
ENSG00000135679MDM29532.072ENSHGLG00000007642MDM49230.932Heterocephalus_glaber_female
ENSG00000135679MDM29995.455ENSHGLG00000020526-9788.367Heterocephalus_glaber_female
ENSG00000135679MDM29532.271ENSHGLG00100006704-9230.932Heterocephalus_glaber_male
ENSG00000135679MDM210096.703ENSHGLG00100000441-10090.187Heterocephalus_glaber_male
ENSG00000135679MDM29931.546ENSHCOG00000008924mdm49231.963Hippocampus_comes
ENSG00000135679MDM27750.000ENSIPUG00000024447mdm49231.315Ictalurus_punctatus
ENSG00000135679MDM29432.114ENSSTOG00000004184MDM49230.720Ictidomys_tridecemlineatus
ENSG00000135679MDM210096.154ENSSTOG00000014702-9993.061Ictidomys_tridecemlineatus
ENSG00000135679MDM28931.365ENSSTOG00000024007-6230.142Ictidomys_tridecemlineatus
ENSG00000135679MDM28354.444ENSJJAG00000017144Mdm47554.444Jaculus_jaculus
ENSG00000135679MDM29586.885ENSLACG00000010207MDM29961.460Latimeria_chalumnae
ENSG00000135679MDM28842.763ENSLAFG00000002169MDM47355.556Loxodonta_africana
ENSG00000135679MDM210095.604ENSLAFG00000005885MDM29987.195Loxodonta_africana
ENSG00000135679MDM2100100.000ENSMFAG00000042359MDM210099.476Macaca_fascicularis
ENSG00000135679MDM29530.388ENSMFAG00000033606MDM47254.098Macaca_fascicularis
ENSG00000135679MDM29530.968ENSMMUG00000011236MDM47254.098Macaca_mulatta
ENSG00000135679MDM2100100.000ENSMMUG00000014193MDM2100100.000Macaca_mulatta
ENSG00000135679MDM2100100.000ENSMNEG00000041135MDM2100100.000Macaca_nemestrina
ENSG00000135679MDM29530.134ENSMNEG00000026547MDM47557.143Macaca_nemestrina
ENSG00000135679MDM29432.510ENSMLEG00000032041MDM47054.930Mandrillus_leucophaeus
ENSG00000135679MDM2100100.000ENSMLEG00000042099MDM2100100.000Mandrillus_leucophaeus
ENSG00000135679MDM28382.895ENSMGAG00000010513MDM29667.841Meleagris_gallopavo
ENSG00000135679MDM28831.841ENSMAUG00000017821-9030.222Mesocricetus_auratus
ENSG00000135679MDM28732.000ENSMAUG00000009703-8730.357Mesocricetus_auratus
ENSG00000135679MDM210092.308ENSMICG00000046928-9972.490Microcebus_murinus
ENSG00000135679MDM210095.604ENSMICG00000029037-10090.566Microcebus_murinus
ENSG00000135679MDM28158.025ENSMICG00000017021MDM47054.930Microcebus_murinus
ENSG00000135679MDM28357.303ENSMOCG00000002099Mdm47457.303Microtus_ochrogaster
ENSG00000135679MDM210096.154ENSMOCG00000008043Mdm29987.347Microtus_ochrogaster
ENSG00000135679MDM27456.627ENSMODG00000001605MDM49232.649Monodelphis_domestica
ENSG00000135679MDM29984.211ENSMODG00000007219-9976.016Monodelphis_domestica
ENSG00000135679MDM29930.000ENSMALG00000020663mdm46955.072Monopterus_albus
ENSG00000135679MDM29994.595MGP_CAROLIEiJ_G0015836Mdm29979.242Mus_caroli
ENSG00000135679MDM28051.786MGP_CAROLIEiJ_G0014593Mdm47458.427Mus_caroli
ENSG00000135679MDM210038.571ENSMUSG00000054387Mdm49632.024Mus_musculus
ENSG00000135679MDM29994.595ENSMUSG00000020184Mdm29980.847Mus_musculus
ENSG00000135679MDM29341.538MGP_PahariEiJ_G0027829Mdm47458.427Mus_pahari
ENSG00000135679MDM29994.595MGP_PahariEiJ_G0031251Mdm29980.677Mus_pahari
ENSG00000135679MDM29994.595MGP_SPRETEiJ_G0016659Mdm29981.377Mus_spretus
ENSG00000135679MDM210038.571MGP_SPRETEiJ_G0015400Mdm47458.427Mus_spretus
ENSG00000135679MDM210096.296ENSMPUG00000017505MDM210093.279Mustela_putorius_furo
ENSG00000135679MDM29930.346ENSMPUG00000011721MDM47454.545Mustela_putorius_furo
ENSG00000135679MDM210094.231ENSMLUG00000009997MDM29990.101Myotis_lucifugus
ENSG00000135679MDM28253.571ENSMLUG00000007129MDM46550.000Myotis_lucifugus
ENSG00000135679MDM28450.000ENSNGAG00000012344Mdm49930.962Nannospalax_galili
ENSG00000135679MDM210096.154ENSNGAG00000012154Mdm29988.776Nannospalax_galili
ENSG00000135679MDM29432.305ENSNLEG00000014271MDM47054.930Nomascus_leucogenys
ENSG00000135679MDM2100100.000ENSNLEG00000003757MDM2100100.000Nomascus_leucogenys
ENSG00000135679MDM27955.000ENSMEUG00000012624-8155.000Notamacropus_eugenii
ENSG00000135679MDM210096.154ENSOPRG00000009677MDM29985.510Ochotona_princeps
ENSG00000135679MDM29431.062ENSOPRG00000013878MDM45631.618Ochotona_princeps
ENSG00000135679MDM29431.967ENSODEG00000013499MDM49232.285Octodon_degus
ENSG00000135679MDM29977.444ENSODEG00000000416-9783.453Octodon_degus
ENSG00000135679MDM210094.231ENSODEG00000004028-9984.694Octodon_degus
ENSG00000135679MDM29986.275ENSODEG00000006648-9972.802Octodon_degus
ENSG00000135679MDM28756.140ENSOANG00000013464MDM49731.579Ornithorhynchus_anatinus
ENSG00000135679MDM29472.665ENSOANG00000005942MDM29972.851Ornithorhynchus_anatinus
ENSG00000135679MDM29889.820ENSOCUG00000011354-9986.708Oryctolagus_cuniculus
ENSG00000135679MDM28354.545ENSOCUG00000000005MDM47056.522Oryctolagus_cuniculus
ENSG00000135679MDM210097.802ENSOCUG00000010899-6493.535Oryctolagus_cuniculus
ENSG00000135679MDM29440.000ENSOGAG00000011679MDM49731.349Otolemur_garnettii
ENSG00000135679MDM210097.802ENSOGAG00000034779MDM210084.848Otolemur_garnettii
ENSG00000135679MDM210090.385ENSOGAG00000011845-10085.132Otolemur_garnettii
ENSG00000135679MDM29732.475ENSOARG00000002783-9932.277Ovis_aries
ENSG00000135679MDM210098.901ENSOARG00000013821-10093.483Ovis_aries
ENSG00000135679MDM210098.901ENSOARG00000000570-9993.333Ovis_aries
ENSG00000135679MDM29432.265ENSPPAG00000030518MDM47054.930Pan_paniscus
ENSG00000135679MDM2100100.000ENSPPAG00000032775MDM2100100.000Pan_paniscus
ENSG00000135679MDM28355.682ENSPPRG00000025076MDM49631.911Panthera_pardus
ENSG00000135679MDM210098.901ENSPPRG00000000082MDM210094.424Panthera_pardus
ENSG00000135679MDM28355.682ENSPTIG00000011372MDM49631.677Panthera_tigris_altaica
ENSG00000135679MDM210098.901ENSPTIG00000016929MDM210094.908Panthera_tigris_altaica
ENSG00000135679MDM29432.265ENSPTRG00000001889MDM47054.930Pan_troglodytes
ENSG00000135679MDM2100100.000ENSPTRG00000005203MDM2100100.000Pan_troglodytes
ENSG00000135679MDM29432.305ENSPANG00000008555MDM46954.930Papio_anubis
ENSG00000135679MDM2100100.000ENSPANG00000005563MDM210099.476Papio_anubis
ENSG00000135679MDM28382.895ENSPSIG00000016379-9968.468Pelodiscus_sinensis
ENSG00000135679MDM28447.619ENSPEMG00000018483Mdm49931.418Peromyscus_maniculatus_bairdii
ENSG00000135679MDM29431.772ENSPCIG00000017446MDM46956.338Phascolarctos_cinereus
ENSG00000135679MDM29987.179ENSPCIG00000005357-9977.597Phascolarctos_cinereus
ENSG00000135679MDM29432.305ENSPPYG00000000315MDM47054.930Pongo_abelii
ENSG00000135679MDM2100100.000ENSPPYG00000004754MDM210098.793Pongo_abelii
ENSG00000135679MDM26972.093ENSPCAG00000007019MDM46072.093Procavia_capensis
ENSG00000135679MDM210092.308ENSPCAG00000008949MDM29985.163Procavia_capensis
ENSG00000135679MDM29493.622ENSPCOG00000018521-10093.766Propithecus_coquereli
ENSG00000135679MDM29633.198ENSPCOG00000024397MDM49633.266Propithecus_coquereli
ENSG00000135679MDM29997.368ENSPVAG00000006202MDM29988.187Pteropus_vampyrus
ENSG00000135679MDM28156.790ENSPVAG00000005663MDM46855.738Pteropus_vampyrus
ENSG00000135679MDM28259.756ENSRNOG00000009696Mdm47058.571Rattus_norvegicus
ENSG00000135679MDM29993.243ENSRNOG00000006304Mdm29983.061Rattus_norvegicus
ENSG00000135679MDM2100100.000ENSRBIG00000028561MDM2100100.000Rhinopithecus_bieti
ENSG00000135679MDM29431.893ENSRBIG00000038824MDM47054.930Rhinopithecus_bieti
ENSG00000135679MDM2100100.000ENSRROG00000045589-10099.195Rhinopithecus_roxellana
ENSG00000135679MDM29431.893ENSRROG00000027771MDM47054.930Rhinopithecus_roxellana
ENSG00000135679MDM29532.207ENSSBOG00000036183-7054.930Saimiri_boliviensis_boliviensis
ENSG00000135679MDM29430.573ENSSBOG00000020446-9430.851Saimiri_boliviensis_boliviensis
ENSG00000135679MDM2100100.000ENSSBOG00000014544-100100.000Saimiri_boliviensis_boliviensis
ENSG00000135679MDM210070.370ENSSHAG00000000124-10066.587Sarcophilus_harrisii
ENSG00000135679MDM28257.831ENSSHAG00000007767MDM47257.831Sarcophilus_harrisii
ENSG00000135679MDM29985.897ENSSHAG00000010284-9974.141Sarcophilus_harrisii
ENSG00000135679MDM28348.000ENSSFOG00015001112mdm49231.857Scleropages_formosus
ENSG00000135679MDM210094.505ENSSARG00000005801MDM210085.918Sorex_araneus
ENSG00000135679MDM29731.944ENSSARG00000004179MDM47649.533Sorex_araneus
ENSG00000135679MDM29986.842ENSSPUG00000000964MDM29965.253Sphenodon_punctatus
ENSG00000135679MDM210097.802ENSSSCG00000000488MDM210093.483Sus_scrofa
ENSG00000135679MDM29531.984ENSSSCG00000015284MDM47355.682Sus_scrofa
ENSG00000135679MDM28388.158ENSTGUG00000006836MDM29768.433Taeniopygia_guttata
ENSG00000135679MDM29332.601ENSTGUG00000017483MDM48432.028Taeniopygia_guttata
ENSG00000135679MDM210090.576ENSTBEG00000013758MDM28188.889Tupaia_belangeri
ENSG00000135679MDM29482.460ENSTTRG00000015715MDM29182.965Tursiops_truncatus
ENSG00000135679MDM29532.851ENSTTRG00000012174MDM49632.851Tursiops_truncatus
ENSG00000135679MDM29930.285ENSUAMG00000007328MDM47356.977Ursus_americanus
ENSG00000135679MDM210098.901ENSUAMG00000018322-10096.226Ursus_americanus
ENSG00000135679MDM29531.377ENSUMAG00000003452MDM49531.440Ursus_maritimus
ENSG00000135679MDM210098.901ENSUMAG00000020757MDM210094.908Ursus_maritimus
ENSG00000135679MDM210097.531ENSVPAG00000007456MDM29988.187Vicugna_pacos
ENSG00000135679MDM28158.025ENSVPAG00000012034MDM47454.930Vicugna_pacos
ENSG00000135679MDM29532.724ENSVVUG00000014855MDM49632.106Vulpes_vulpes
ENSG00000135679MDM29878.481ENSXETG00000001434mdm29857.228Xenopus_tropicalis
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000122negative regulation of transcription by RNA polymerase II9271120.17310983.IDAProcess
GO:0001568blood vessel development-IEAProcess
GO:0001974blood vessel remodeling-IEAProcess
GO:0002027regulation of heart rate-IEAProcess
GO:0002039p53 binding9529249.15053879.20173098.25417702.IPIFunction
GO:0003181atrioventricular valve morphogenesis-IEAProcess
GO:0003203endocardial cushion morphogenesis-IEAProcess
GO:0003281ventricular septum development-IEAProcess
GO:0003283atrial septum development-IEAProcess
GO:0004842ubiquitin-protein transferase activity9450543.IDAFunction
GO:0004842ubiquitin-protein transferase activity20173098.IMPFunction
GO:0005515protein binding7791904.8875929.9271120.9529249.10196247.10608892.11178989.12740913.12915590.15144954.15195100.15313915.15314173.15364927.15604276.15878855.15916963.16023600.16173922.16374512.16402859.16432196.16474402.16845383.17006543.17080083.17110929.17139261.17159902.17170761.17237821.17268548.17290220.17310983.17347673.17373842.17438265.17470788.17875722.17909018.17936559.17984062.18172499.18191226.18309296.18316739.18332867.18485870.18548200.18560357.18566590.18583933.18952844.19015526.19098711.19166840.19166854.19218448.19234109.19249676.19255450.19369353.19372219.19411066.19483087.19656744.19713960.19833129.19879840.20173098.20181722.20195357.20591429.20598683.20708156.20713054.20856200.20871633.21132010.21170087.21333377.21399665.21460856.21726810.21857681.21988832.22056774.22085928.22103682.22124327.22493164.22510990.22575647.22653443.22659184.22819825.22869143.22902369.22975381.23092970.23260144.23397142.23507139.23776060.24207125.24667498.25241761.29997244.IPIFunction
GO:0005634nucleus10360174.29295817.IDAComponent
GO:0005634nucleus15314173.21726810.IMPComponent
GO:0005654nucleoplasm10707090.12915590.IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005730nucleolus10707090.22869143.IDAComponent
GO:0005730nucleolus11718560.IMPComponent
GO:0005737cytoplasm15314173.21726810.IMPComponent
GO:0005829cytosol-TASComponent
GO:0005886plasma membrane-TASComponent
GO:0006511ubiquitin-dependent protein catabolic process11278372.15314173.16173922.17310983.IDAProcess
GO:0006511ubiquitin-dependent protein catabolic process17237821.IGIProcess
GO:0006511ubiquitin-dependent protein catabolic process16479015.18560357.24506068.IMPProcess
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest21726810.IMPProcess
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest-TASProcess
GO:0007089traversing start control point of mitotic cell cycle-IEAProcess
GO:00080975S rRNA binding24120868.IDAFunction
GO:0008270zinc ion binding10722742.IDAFunction
GO:0008284positive regulation of cell proliferation7791904.TASProcess
GO:0010039response to iron ion-IEAProcess
GO:0010628positive regulation of gene expression-IEAProcess
GO:0010955negative regulation of protein processing-IEAProcess
GO:0010977negative regulation of neuron projection development-IEAProcess
GO:0016032viral process-IEAProcess
GO:0016567protein ubiquitination9450543.15878855.19656744.20153724.IDAProcess
GO:0016579protein deubiquitination-TASProcess
GO:0016604nuclear body10360174.IDAComponent
GO:0016874ligase activity17142452.IDAFunction
GO:0016925protein sumoylation-IEAProcess
GO:0018205peptidyl-lysine modification19372219.IMPProcess
GO:0019789SUMO transferase activity21900752.EXPFunction
GO:0019899enzyme binding15577914.17290220.18566590.20173098.IPIFunction
GO:0019904protein domain specific binding16479015.IPIFunction
GO:0030666endocytic vesicle membrane-TASComponent
GO:0031625ubiquitin protein ligase binding18382127.29295817.IPIFunction
GO:0031648protein destabilization9529249.10360174.15314173.IDAProcess
GO:0031648protein destabilization16479015.18560357.IMPProcess
GO:0032026response to magnesium ion-IEAProcess
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process11278372.IDAProcess
GO:0032991protein-containing complex9529249.17310983.IDAComponent
GO:0032991protein-containing complex11718560.15314173.16479015.IMPComponent
GO:0033612receptor serine/threonine kinase binding-IEAFunction
GO:0034504protein localization to nucleus10360174.IDAProcess
GO:0036369transcription factor catabolic process20181722.TASProcess
GO:0042176regulation of protein catabolic process9153395.IDAProcess
GO:0042220response to cocaine-IEAProcess
GO:0042802identical protein binding17159902.17936559.22493164.IPIFunction
GO:0042975peroxisome proliferator activated receptor binding-IEAFunction
GO:0043021ribonucleoprotein complex binding24120868.IDAFunction
GO:0043130ubiquitin binding29295817.IDAFunction
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process-IEAProcess
GO:0043278response to morphine-IEAProcess
GO:0043518negative regulation of DNA damage response, signal transduction by p53 class mediator9529249.10360174.IDAProcess
GO:0045184establishment of protein localization10360174.IDAProcess
GO:0045202synapse-IEAComponent
GO:0045472response to ether-IEAProcess
GO:0045892negative regulation of transcription, DNA-templated9271120.IDAProcess
GO:0045892negative regulation of transcription, DNA-templated16479015.25417702.IMPProcess
GO:0045931positive regulation of mitotic cell cycle17290220.IMPProcess
GO:0046677response to antibiotic20810912.IEPProcess
GO:0046827positive regulation of protein export from nucleus-IEAProcess
GO:0047485protein N-terminus binding11718560.IPIFunction
GO:0048545response to steroid hormone-IEAProcess
GO:0051603proteolysis involved in cellular protein catabolic process25417702.IMPProcess
GO:0051865protein autoubiquitination16479015.17237821.IMPProcess
GO:0060411cardiac septum morphogenesis-IEAProcess
GO:0061630ubiquitin protein ligase activity15314173.17310983.IDAFunction
GO:0061630ubiquitin protein ligase activity16479015.18560357.19372219.