EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
22406481Utility of p63 and high molecular weight cytokeratin in the distinction between urothelial carcinoma with prostatic stromal invasion and urothelial carcinoma with colonisation of prostatic ducts and acini.Pathology2012 AprChastain ECdoi: 10.1097/PAT.0b013e3283511c73.
18296695Identification of CKAP4/p63 as a major substrate of the palmitoyl acyltransferase DHHC2, a putative tumor suppressor, using a novel proteomics method.Mol Cell Proteomics2008 JulZhang Jdoi: 10.1074/mcp.M800069-MCP200
27322059CKAP4 is a Dickkopf1 receptor and is involved in tumor progression.J Clin Invest2016 Jul 1Kimura Hdoi: 10.1172/JCI84658
19144824Palmitoylation of cytoskeleton associated protein 4 by DHHC2 regulates antiproliferative factor-mediated signaling.Mol Biol Cell2009 MarPlaney SLdoi: 10.1091/mbc.E08-08-0849

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr12106239204SilentNAV543V0.18
BLCAchr12106239950Missense_MutationNAE295K0.29
BLCAchr12106240337Missense_MutationnovelQ166E0.14
BLCAchr12106239208Missense_MutationNAS542L0.07
BLCAchr12106240205Nonsense_MutationnovelE210*0.17
BRCAchr12106239849SilentnovelL328L0.17
BRCAchr121062380933'UTRnovel0.11
BRCAchr12106239728Missense_MutationNAE369Q0.15
BRCAchr12106239344Missense_MutationnovelP497T0.2
CESCchr121062390043'UTRrs3730763030.15
CESCchr12106240009Missense_MutationNAS275F0.4
CESCchr12106239342SilentNAP497P0.34
CESCchr12106240068SilentNAF255F0.1
CESCchr121062383083'UTRnovel0.41
COADchr12106239739Missense_Mutationrs141394460R365H0.2
COADchr12106240229Missense_Mutationrs376479872E202K0.21
COADchr121062389693'UTRnovel0.25
COADchr121062390033'UTRrs2006760080.39
COADchr12106239645Silentrs758624024S396S0.37
ESCAchr121062383713'UTRnovel0.14
ESCAchr121062383543'UTRnovel0.25
GBMchr12106239353Missense_MutationnovelG494C0.28
GBMchr12106239473Missense_Mutationrs749256244R454C0.34
GBMchr121062390043'UTRrs3730763030.38
GBMchr121062389623'UTRnovel0.45
HNSCchr12106239547Missense_MutationnovelR429P0.06
HNSCchr12106239265Missense_Mutationrs374979802R523L0.34
HNSCchr12106239366SilentnovelL489L0.26
HNSCchr121062389183'UTRnovel0.3
KIRCchr12106239926Missense_MutationNAR303G0.38
KIRPchr12106239715Missense_MutationnovelL373R0.29
LAMLchr12106239156Missense_MutationnovelS559R0.04
LAMLchr12106239548Missense_MutationNAR429C0.35
LGGchr12106239646Missense_Mutationrs375178726S396L0.48
LUADchr12106239203Missense_MutationNAS544G0.41
LUADchr12106239302Missense_MutationnovelH511N0.21
LUADchr121062389293'UTRnovel0.12
LUADchr12106239611Nonsense_MutationNAG408*0.5
LUADchr12106240244Missense_MutationnovelV197I0.18
LUADchr12106239485Missense_MutationnovelA450S0.23
LUADchr12106239678Silentrs371266776H385H0.38
LUADchr12106239944Nonsense_MutationnovelQ297*0.26
LUADchr12106239785Nonsense_MutationnovelQ350*0.23
LUADchr12106239623Missense_MutationNAQ404E0.41
LUSCchr121062388833'UTRnovel0.13
LUSCchr12106239093Missense_MutationnovelL580F0.25
LUSCchr12106239790Missense_MutationNAA348V0.42
LUSCchr12106240160Missense_Mutationrs767034363A225T0.14
LUSCchr12106240316Nonsense_MutationnovelE173*0.12
OVchr12106239596Missense_MutationnovelL413V0.04
OVchr12106239906SilentnovelA309A0.14
OVchr12106239988Missense_MutationnovelN282S0.06
OVchr12106239645SilentNAS396S0.8
OVchr12106247510SilentNAL114L1
PAADchr12106239948Missense_MutationnovelE295D0.18
PRADchr121062390023'UTRrs3763625160.19
PRADchr12106239893Missense_MutationnovelL314I0.37
READchr12106239781Missense_MutationnovelA351G0.15
READchr12106239352Missense_MutationNAG494V0.06
READchr12106239854Missense_Mutationrs769777070E327K0.37
SARCchr121062382123'UTRnovel0.26
SARCchr12106239698Nonsense_MutationnovelQ379*0.14
SARCchr12106239840SilentnovelL331L0.26
SARCchr12106239842Missense_MutationnovelL331F0.26
SKCMchr12106239567Silentrs761457456S422S0.17
SKCMchr12106239568Missense_MutationNAS422F0.18
SKCMchr12106239646Missense_Mutationrs375178726S396L0.08
SKCMchr12106240342Missense_MutationnovelS164F0.18
SKCMchr12106240311SilentnovelS174S0.13
SKCMchr12106239517Missense_MutationNAS439F0.1
SKCMchr12106239702SilentnovelL377L0.26
SKCMchr12106240068SilentNAF255F0.35
SKCMchr12106239762SilentNAL357L0.37
SKCMchr121062389383'UTRnovel0.94
SKCMchr121062389553'UTRnovel0.39
SKCMchr121062389193'UTRnovel0.52
SKCMchr12106239525Silentrs751356737S436S0.23
SKCMchr12106239568Missense_MutationNAS422F0.41
SKCMchr12106239568Missense_MutationNAS422F0.3
SKCMchr12106239523Missense_MutationnovelL437H0.29
SKCMchr12106240137SilentnovelS232S0.29
SKCMchr12106239747Silentrs763063503S362S0.68
STADchr12106240145Missense_MutationNAF230V0.19
STADchr12106239501Silentrs112234315H444H0.33
STADchr121062390033'UTRrs2006760080.19
STADchr12106239928Missense_MutationnovelS302F0.43
STADchr121062390043'UTRrs3730763030.12
STADchr12106239436Missense_MutationNAD466V0.13
STADchr121062389693'UTRnovel0.21
STADchr12106239550Missense_MutationNAA428V0.27
STADchr12106239857Missense_Mutationrs200500476R326C0.29
STADchr12106240141Missense_MutationNAT231M0.09
STADchr12106239946Missense_MutationNAI296T0.31
STADchr12106239232Frame_Shift_DelnovelS534Ffs*30.3
STADchr12106240048Missense_MutationNAS262N0.38
STADchr12106239463Missense_MutationnovelG457V0.09
STADchr12106239809Missense_MutationNAA342T0.17
TGCTchr12106247491Missense_MutationnovelA121T0.21
THCAchr12106239927SilentNAS302S0.15
UCECchr12106239254Missense_MutationnovelQ527E0.13
UCECchr121062388393'UTRNA0.26
UCECchr121062382353'UTRnovel0.36
UCECchr121062390213'UTRnovel0.44
UCECchr12106239500Missense_Mutationrs546309777E445K0.39
UCECchr12106239806Missense_Mutationrs764573182D343N0.5
UCECchr121062381083'UTRnovel0.37
UCECchr12106239672Silentrs149785649P387P0.55
UCECchr121062381743'UTRnovel0.48
UCECchr12106240280Missense_MutationNAL185I0.21
UCECchr12106239035Missense_Mutationrs773178493E600K0.12
UCECchr12106239238Missense_MutationNAR532I0.24
UCECchr12106239721Missense_Mutationrs747208266R371Q0.3
UCECchr12106239383Missense_Mutationrs771014402G484S0.29
UCECchr12106240244Missense_MutationnovelV197F0.32
UCECchr12106239774Silentrs778463864T353T0.31
UCECchr12106240185Silentrs373289408S216S0.43
UCECchr121062382233'UTRnovel0.4
UCECchr12106239455Missense_MutationnovelS460P0.55
UCECchr12106240111Missense_MutationnovelL241P0.27
UCECchr12106240157Missense_MutationNAR226W0.38
UCECchr12106239182Nonsense_MutationnovelK551*0.22
UCECchr12106240238Missense_MutationnovelR199W0.24
UCECchr121062380803'UTRnovel0.43
UCECchr12106239035Missense_Mutationrs773178493E600K0.34
UCECchr12106240311SilentNAS174S0.35
UCECchr12106239131Nonsense_MutationnovelE568*0.36
UCECchr12106239035Missense_Mutationrs773178493E600K0.22
UCECchr12106239911Missense_MutationnovelE308K0.26
UCECchr12106240185Silentrs373289408S216S0.48
UCECchr121062380173'UTRnovel0.58
UCECchr12106239208Missense_MutationNAS542L0.45
UCECchr12106239277Missense_MutationnovelA519D0.47
UCECchr12106239120SilentNAE571E0.24
UCECchr12106240044Missense_MutationnovelQ263H0.1
UCECchr12106239502Missense_MutationnovelH444L0.45
UCECchr12106239861Missense_MutationNAE324D0.28
UCECchr12106239923Nonsense_MutationNAE304*0.32
UCECchr121062390013'UTRrs7731271160.39
UCECchr12106240131Missense_MutationnovelE234D0.13
UCSchr12106240131Missense_MutationnovelE234D0.38

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.03330.20414
CHOLDEL0.22220.067545
HNSCDEL0.06130.22646
LUADDEL0.14920.0059643
LUSCDEL0.09580.038823
PAADDEL0.18480.0030251
PRADAMP0.05690.016187
READDEL0.08480.064633
SKCMDEL0.19620.00079981

Survival Analysis
CancerP-value Q-value
STAD0.012

Kaplan-Meier Survival Analysis

SARC0.0025

Kaplan-Meier Survival Analysis

MESO0.00012

Kaplan-Meier Survival Analysis

ACC0.019

Kaplan-Meier Survival Analysis

SKCM0.043

Kaplan-Meier Survival Analysis

ESCA0.035

Kaplan-Meier Survival Analysis

KIRP0.0028

Kaplan-Meier Survival Analysis

BLCA0.025

Kaplan-Meier Survival Analysis

GBM0.0034

Kaplan-Meier Survival Analysis

LIHC0.0001

Kaplan-Meier Survival Analysis

LGG0.0001

Kaplan-Meier Survival Analysis

CHOL0.028

Kaplan-Meier Survival Analysis

THCA0.0087

Kaplan-Meier Survival Analysis

LUAD0.0001

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000136026 (Gene tree)
Gene ID
10970
Gene Symbol
CKAP4
Alias
P63|CLIMP-63|ERGIC-63
Full Name
cytoskeleton associated protein 4
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
66,403 bases
Position
chr12:106,237,877-106,304,279
Accession
16991
RBP type
non-canonical RBP
Summary
(Cytoskeleton Associated Protein 4) is a Protein Coding gene. Diseases associated with CKAP4 include Interstitial Cystitis and Cystitis. Among its related pathways are Protein processing in endoplasmic reticulum and Surfactant metabolism. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity. An important paralog of this gene is SMC4.
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNANascentRICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
30584103SENCR stabilizes vascular endothelial cell adherens junctions through interaction with CKAP4.Proc Natl Acad Sci U S A2019 Jan 8Lyu Qdoi: 10.1073/pnas.1810729116
18708633Role of P63 (CKAP4) in binding of surfactant protein-A to type II pneumocytes.Am J Physiol Lung Cell Mol Physiol2008 OctBates SRdoi: 10.1152/ajplung.90233.2008
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000553039CKAP4-203573-ENSP0000044924026 (aa)-F8VVU0
ENST00000552828CKAP4-202831--- (aa)--
ENST00000378026CKAP4-2013093-ENSP00000367265602 (aa)-Q07065
Gene Model
Click here to download ENSG00000136026's gene model file
Pathways
Pathway IDPathway NameSource
hsa04141Protein processing in endoplasmic reticulumKEGG
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000136026rs653926212106290987?General cognitive ability29844566z-score decrease4.631EFO_0004337
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000136026's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000136026CKAP410079.270ENSMUSG00000046841Ckap48682.341Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0005783endoplasmic reticulum21873635.IBAComponent
GO:0005783endoplasmic reticulum19401338.IDAComponent
GO:0005788endoplasmic reticulum lumen-TASComponent
GO:0005789endoplasmic reticulum membrane-IEAComponent
GO:0005791rough endoplasmic reticulum21873635.IBAComponent
GO:0005791rough endoplasmic reticulum24454821.IDAComponent
GO:0005811lipid droplet14741744.IDAComponent
GO:0005829cytosol-IDAComponent
GO:0005856cytoskeleton-IEAComponent
GO:0005886plasma membrane-TASComponent
GO:0016020membrane8314870.TASComponent
GO:0016021integral component of membrane-IEAComponent
GO:0016607nuclear speck-IDAComponent
GO:0035577azurophil granule membrane-TASComponent
GO:0035579specific granule membrane-TASComponent
GO:0036464cytoplasmic ribonucleoprotein granule-IDAComponent
GO:0042599lamellar body-TASComponent
GO:0043312neutrophil degranulation-TASProcess
GO:0043687post-translational protein modification-TASProcess
GO:0044267cellular protein metabolic process-TASProcess
GO:0048471perinuclear region of cytoplasm-IEAComponent
GO:0070062extracellular exosome19056867.HDAComponent
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