EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
23159356The correlation between insulin-like growth factor II mRNA binding protein 3 expression in hepatocellular carcinoma and prognosis.Hepatogastroenterology2013 MayChen LT-
22495359IMP3, NESP55, TTF-1 and CDX2 serve as an immunohistochemical panel in the distinction among small-cell carcinoma, gastrointestinal carcinoid, and pancreatic endocrine tumor metastasized to the liver.Appl Immunohistochem Mol Morphol2012 DecDenby KSdoi: 10.1097/PAI.0b013e3182494009.
19788446IMP-3 expression in melanocytic lesions.J Cutan Pathol2010 MarYu Ldoi: 10.1111/j.1600-0560.2009.01428.x
25982283IMP3 promotes stem-like properties in triple-negative breast cancer by regulating SLUG.Oncogene2016 Mar 3Samanta Sdoi: 10.1038/onc.2015.164
18802962RNA-binding protein insulin-like growth factor II mRNA-binding protein 3 expression promotes tumor invasion and predicts early recurrence and poor prognosis in hepatocellular carcinoma.Hepatology2008 OctJeng YMdoi: 10.1002/hep.22459.
23647076Insulin-like growth factor II mRNA-binding protein 3 expression promotes tumor formation and invasion and predicts poor prognosis in oral squamous cell carcinoma.J Oral Pathol Med2011 OctLin CYdoi: 10.1111/j.1600-0714.2011.01019.x
26353850IMP3 Is Strongly Expressed in Malignant Phyllodes Tumors of the Breast: An Immunohistochemical Study.Int J Surg Pathol2016 FebBellezza Gdoi: 10.1177/1066896915603119
17784873Identification of human leukocyte antigen-A24-restricted epitope peptides derived from gene products upregulated in lung and esophageal cancers as novel targets for immunotherapy.Cancer Sci2007 NovSuda T-
21917080Insulin-like growth factor II mRNA-binding protein 3 expression predicts unfavorable prognosis in patients with neuroblastoma.Cancer Sci2011 DecChen STdoi: 10.1111/j.1349-7006.2011.02100.x
22166630IMP3 is a novel biomarker to predict metastasis and prognosis of gastric adenocarcinoma: a retrospective study.Chin Med J (Engl)2010 DecWang L-
24411949Insulin-like growth factor II messenger RNA-binding protein 3 expression in gastrointestinal mesenchymal tumors.Hum Pathol2014 MarYamamoto Hdoi: 10.1016/j.humpath.2013.10.010
19192721Expression of insulin-like growth factor-II mRNA binding protein 3 (IMP3) in osteosarcoma.Oncol Res2008Do SI-
22555177Increased tumor cell proliferation in mantle cell lymphoma is associated with elevated insulin-like growth factor 2 mRNA-binding protein 3 expression.Mod Pathol2012 SepHartmann EMdoi: 10.1038/modpathol.2012.84
26608347IMP3 Predicts Invasion and Prognosis in Human Lung Adenocarcinoma.Lung2016 FebYan Jdoi: 10.1007/s00408-015-9829-0
17521698Extrapulmonary small cell carcinomas express K homology domain containing protein overexpressed in cancer, but carcinoid tumors do not.Hum Pathol2007 AugSimon R-
25740666Expression of IMP3 and IGF2 in giant cell tumor of spine is associated with tumor recurrence and angiogenesis.Clin Transl Oncol2015 JulZhang Kdoi: 10.1007/s12094-015-1280-4
24135846Expression of insulin-like growth factor II mRNA-binding protein 3 (IMP3) in sacral chordoma.J Neurooncol2014 JanZhou Mdoi: 10.1007/s11060-013-1274-4
28381175Expression profile, clinical significance, and biological function of insulin-like growth factor 2 messenger RNA-binding proteins in non-small cell lung cancer.Tumour Biol2017 AprShi Rdoi: 10.1177/1010428317695928.
27137988Insulin-like growth factor II messenger RNA-binding protein-3 is an indicator of malignant phyllodes tumor of the breast.Hum Pathol2016 SepTakizawa Kdoi: 10.1016/j.humpath.2016.04.007
25183049Expression and clinical significance of IMP3 in microdissected premalignant and malignant pancreatic lesions.Clin Transl Oncol2015 MarWang BJdoi: 10.1007/s12094-014-1216-4
19672661IMP3 is a novel prognostic marker that correlates with colon cancer progression and pathogenesis.Ann Surg Oncol2009 DecLi Ddoi: 10.1245/s10434-009-0648-5.
18835627Merkel cell carcinoma expresses K homology domain-containing protein overexpressed in cancer similar to other high-grade neuroendocrine carcinomas.Hum Pathol2009 FebPryor JGdoi: 10.1016/j.humpath.2008.07.009
18337447Enhanced expression of Rab27A gene by breast cancer cells promoting invasiveness and the metastasis potential by secretion of insulin-like growth factor-II.Mol Cancer Res2008 MarWang JSdoi: 10.1158/1541-7786.MCR-07-0162.
19620937IMP3 expression in human ovarian cancer is associated with improved survival.Int J Gynecol Pathol2009 MayNoske Adoi: 10.1097/PGP.0b013e318189a724.
23812426Post-transcriptional regulation of cyclins D1, D3 and G1 and proliferation of human cancer cells depend on IMP-3 nuclear localization.Oncogene2014 May 29Rivera Vargas Tdoi: 10.1038/onc.2013.252
26617820IMP3 expression in biopsy specimens of colorectal cancer predicts lymph node metastasis and TNM stage.Int J Clin Exp Pathol2015 Sep 1Wei Q-
25216519IGF2BP3-mediated translation in cell protrusions promotes cell invasiveness and metastasis of pancreatic cancer.Oncotarget2014 Aug 30Taniuchi K-
22266872Regulation of IMP3 by EGFR signaling and repression by ERβ: implications for triple-negative breast cancer.Oncogene2012 Nov 1Samanta Sdoi: 10.1038/onc.2011.620
21997684IMP3, a new biomarker to predict progression of cervical intraepithelial neoplasia into invasive cancer.Am J Surg Pathol2011 NovLu Ddoi: 10.1097/PAS.0b013e31823272d4.
24615121Prognostic value of tissue and circulating levels of IMP3 in prostate cancer.Int J Cancer2014 Oct 1Szarvas Tdoi: 10.1002/ijc.28808
26510428MicroRNA-129-1 acts as tumour suppressor and induces cell cycle arrest of GBM cancer cells through targeting IGF2BP3 and MAPK1.J Med Genet2016 JanKouhkan Fdoi: 10.1136/jmedgenet-2015-103225
19427669IMP3 expression in non-small cell lung cancer.Hum Pathol2009 AugBellezza Gdoi: 10.1016/j.humpath.2009.03.019
19357927Diffuse expression of RNA-binding protein IMP3 predicts high-stage lymph node metastasis and poor prognosis in colorectal adenocarcinoma.Ann Surg Oncol2009 JunYuan RHdoi: 10.1245/s10434-009-0446-0
20591150Insulin-like growth factor II mRNA binding protein 3 (IMP3) is overexpressed in prostate cancer and correlates with higher Gleason scores.BMC Cancer2010 Jun 30Ikenberg Kdoi: 10.1186/1471-2407-10-341.
27840950IMP-3 protects the mRNAs of cyclins D1 and D3 from GW182/AGO2-dependent translational repression.Int J Oncol2016 DecDeforzh Edoi: 10.3892/ijo.2016.3750
28412210IMP3 expression in biopsy specimens as a diagnostic biomarker for colorectal cancer.Hum Pathol2017 JunWei Qdoi: 10.1016/j.humpath.2017.03.013
26158423Overexpression of the RNA-binding proteins Lin28B and IGF2BP3 (IMP3) is associated with chemoresistance and poor disease outcome in ovarian cancer.Br J Cancer2015 Jul 28Hsu KFdoi: 10.1038/bjc.2015.254
28193878THADA fusion is a mechanism of IGF2BP3 activation and IGF1R signaling in thyroid cancer.Proc Natl Acad Sci U S A2017 Feb 28Panebianco Fdoi: 10.1073/pnas.1614265114
29217458IMP2 and IMP3 cooperate to promote the metastasis of triple-negative breast cancer through destabilization of progesterone receptor.Cancer Lett2018 Feb 28Kim HYdoi: 10.1016/j.canlet.2017.11.039

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr723346058Missense_MutationnovelE275K0.16
BLCAchr723343752Missense_MutationnovelR348K0.14
BLCAchr723351308Missense_MutationNAS227C0.23
BLCAchr723351465Missense_MutationnovelG175R0.19
BLCAchr723313540SilentnovelI503I0.09
BLCAchr7234701755'UTRnovel0.25
BLCAchr7233123233'UTRnovel0.3
BLCAchr723361585Missense_MutationnovelS117L0.29KH_1
BLCAchr723469958Silentrs371773798L51L0.16
BLCAchr723342124SilentnovelG381G0.14
BRCAchr723470027SilentnovelP28P0.07
BRCAchr723343846Nonsense_MutationNAE317*0.23
BRCAchr723415298Intronnovel0.37
BRCAchr723345983Nonsense_MutationNAK300*0.47
BRCAchr723470048SilentnovelI21I0.05
BRCAchr723415421Intronnovel0.14
BRCAchr723312370Missense_Mutationrs141308145R578W0.21
BRCAchr723351553SilentNAE145E0.22
CESCchr723313562Missense_MutationNAS496C0.11
CESCchr723469950Missense_MutationnovelI54T0.39
CESCchr723313643Missense_MutationNAR469I0.5
CESCchr723317709Missense_MutationnovelA442V0.28
CESCchr723312404SilentnovelQ566Q0.07
CESCchr723317653Missense_MutationnovelE461K0.2
CESCchr723346013Missense_MutationNAR290C0.47
CESCchr723415458Intronnovel0.14
CESCchr723347689Silentrs756431557S243S0.71
COADchr7233122913'UTRnovel0.34
COADchr723347699Missense_MutationNAA240D0.4
COADchr723342083Missense_MutationnovelP395L0.08
COADchr723319165SilentnovelL431L0.24
COADchr7234701445'UTRrs7603597230.48
COADchr723312747Missense_MutationnovelF543L0.38
COADchr723468534Nonsense_MutationnovelE62*0.25
COADchr723351316Missense_MutationNAQ224H0.36
COADchr723317677Missense_MutationNAM453L0.26
COADchr723345981Missense_MutationNAK300N0.17
COADchr723468534Missense_MutationNAE62K0.14
COADchr723342130SilentnovelT379T0.36
COADchr723351483Nonsense_MutationNAR169*0.21
COADchr723351510Missense_Mutationrs145484983A160T0.1
ESCAchr723361556Missense_MutationnovelS127A0.27KH_1
ESCAchr723415214Intronnovel0.4
GBMchr723345998Nonsense_MutationnovelE295*0.24
GBMchr723469976SilentNAP45P0.24
GBMchr723347615Missense_MutationnovelA268D0.08
GBMchr723470004Missense_MutationnovelK36R0.21
HNSCchr7233122933'UTRnovel0.3
HNSCchr723470092Missense_MutationnovelG7R0.34
HNSCchr7233122973'UTRnovel0.16
HNSCchr723343842Nonsense_MutationnovelL318*0.52
HNSCchr723351469SilentnovelG173G0.24
KIRCchr723468511Missense_MutationNAE69D0.26
KIRPchr723312733Splice_SitenovelX547_splice0.5
KIRPchr723312734Splice_SitenovelX547_splice0.51
KIRPchr723317651Missense_MutationnovelE461D0.42
LAMLchr7233123423'UTRnovel0.04
LGGchr7233122903'UTRrs7734269380.58
LGGchr723342154Silentrs777472952N371N0.41
LIHCchr723351402Missense_MutationNAL196M0.49
LIHCchr723313636SilentNAY471Y0.49
LIHCchr723469976SilentNAP45P0.26
LIHCchr723351481SilentnovelR169R0.18
LIHCchr723470005Nonsense_MutationNAK36*0.38
LUADchr723351472SilentnovelR172R0.16
LUADchr723319189Missense_MutationNAK423N0.26
LUADchr723470022Missense_MutationNAS30W0.05
LUADchr723343839Missense_MutationNAT319K0.22
LUADchr723319238Missense_MutationNAT407S0.31
LUADchr7234701705'UTRnovel0.28
LUADchr723361583Missense_Mutationrs267601463E118K0.05KH_1
LUADchr723470093SilentNAI6I0.18
LUADchr723347725SilentNAV231V0.2
LUADchr7233122353'UTRnovel0.19
LUADchr723351344Missense_MutationNAG215V0.31
LUADchr723319185Missense_MutationnovelG425C0.33
LUADchr723342083Missense_MutationnovelP395H0.43
LUADchr723312397Missense_MutationNAL569M0.23
LUADchr723343723Missense_MutationnovelM358L0.24
LUADchr723346035Missense_MutationnovelL282F0.2
LUSCchr723361580Missense_MutationnovelT119A0.16KH_1
LUSCchr723342098Missense_MutationnovelP390L0.43
LUSCchr723415424Intronnovel0.38
LUSCchr7233122913'UTRnovel0.14
LUSCchr723345968Missense_Mutationrs375047828D305Y0.14
LUSCchr723351421SilentNAS189S0.32
LUSCchr723345974Missense_MutationnovelE303Q0.24
LUSCchr723342116Missense_MutationnovelP384L0.22
LUSCchr723361549Frame_Shift_DelnovelK129Rfs*80.19KH_1
LUSCchr723317653Missense_Mutationrs775406714E461Q0.17
OVchr723351446Missense_MutationNAR181M0.32
OVchr723319197Missense_MutationnovelI421L0.08
OVchr723418776Splice_RegionnovelE95E0.33
OVchr723347616Missense_MutationnovelA268S0.06
OVchr723343772SilentNAE341E0.11
OVchr723351317Frame_Shift_DelnovelK223Dfs*40.05
OVchr723342085SilentNAT394T0.25
OVchr723345985Frame_Shift_InsnovelL299Rfs*20.05
PAADchr723418794SilentnovelP89P0.13
PRADchr7233122913'UTRnovel0.33
READchr723346041Missense_MutationnovelK280N0.36
READchr723347708Missense_Mutationrs202212306A237V0.4
SARCchr723470062Missense_MutationnovelD17Y0.12
SARCchr723415468Intronnovel0.53
SARCchr7233120883'UTRnovel0.26
SKCMchr723361720Nonsense_MutationNAQ103*0.34KH_1
SKCMchr723361707Missense_MutationNAV107G0.52KH_1
SKCMchr723418804Missense_Mutationrs764971109R86Q0.59KH_1
SKCMchr723342171Missense_MutationNAP366S0.34
SKCMchr723345940Missense_MutationNAP314L0.21
SKCMchr723345941Missense_MutationnovelP314S0.35
SKCMchr723351545Missense_MutationNAT148I0.17KH_1
SKCMchr723313525Missense_MutationnovelK508N0.3
SKCMchr723312381Missense_MutationNAP574H0.35
SKCMchr723351578Missense_MutationnovelD137A0.32KH_1
SKCMchr723351579Missense_MutationnovelD137N0.32KH_1
SKCMchr723342105Missense_MutationNAG388R0.17
SKCMchr723361714Missense_MutationNAG105R0.59KH_1
SKCMchr723312425SilentNAQ559Q0.36
STADchr723345976Frame_Shift_InsNAI302Nfs*20.38
STADchr723319136Splice_SitenovelX440_splice0.18
STADchr723418792Missense_MutationnovelP90H0.19KH_1
STADchr723469973SilentNAD46D0.43
STADchr723469973SilentNAD46D0.41
STADchr7234701445'UTRrs7603597230.44
STADchr723312450Missense_MutationNAR551I0.34
STADchr723345976Missense_MutationNAI302N0.4
STADchr723319239Missense_MutationnovelT407A0.45
STADchr723468499SilentnovelS73S0.37
STADchr723319256Splice_SitenovelX402_splice0.24
STADchr723345977Frame_Shift_DelNAI302Lfs*170.34
STADchr723312398SilentNAA568A0.26
STADchr723347689Silentrs756431557S243S0.11
STADchr7234701295'UTRrs7743769890.45
THYMchr7233119073'UTRnovel0.09
UCECchr7233122603'UTRnovel0.32
UCECchr723343818Missense_Mutationrs199566927T326N0.35
UCECchr723347679Missense_Mutationrs758058585L247F0.34
UCECchr723313643Missense_MutationNAR469I0.06
UCECchr723468534Missense_MutationNAE62K0.38
UCECchr723319183SilentnovelG425G0.44
UCECchr7233122893'UTRnovel0.42
UCECchr723414890Intronnovel0.05
UCECchr723343758Missense_MutationNAK346T0.44
UCECchr723343725Missense_MutationnovelS357Y0.43
UCECchr7233117513'UTRnovel0.27
UCECchr723346033Missense_MutationnovelA283V0.28
UCECchr723319243Silentrs768566146T405T0.36
UCECchr723415020Intronnovel0.39
UCECchr7233122843'UTRnovel0.27
UCECchr723347637Missense_MutationnovelL261M0.24
UCECchr7233122593'UTRnovel0.21
UCECchr723319193Missense_MutationNAG422D0.27
UCECchr723418795Missense_MutationnovelP89L0.16KH_1
UCECchr723470082Missense_Mutationrs768186705S10N0.22
UCECchr7233117503'UTRnovel0.56
UCECchr723361687Splice_Regionnovel0.24
UCECchr7233113713'UTRnovel0.4
UCECchr723319155Missense_MutationnovelA435T0.3
UCECchr723351342Missense_MutationNAA216T0.23
UCECchr723414678Intronnovel0.2
UCECchr723414872Intronnovel0.22
UCECchr7233117513'UTRnovel0.27
UCECchr7233123353'UTRnovel0.3
UCECchr723346012Missense_MutationnovelR290H0.26
UCECchr723418805Nonsense_MutationnovelR86*0.29KH_1
UCECchr723312780SilentnovelN532N0.2
UCECchr723347655Missense_MutationnovelA255T0.39
UCECchr7233121283'UTRnovel0.45
UCECchr723415447Intronnovel0.49
UCECchr723414729Intronnovel0.6
UCECchr7233117513'UTRnovel0.39
UCECchr723313618Missense_MutationnovelE477D0.38
UCECchr723345975SilentNAI302I0.44
UCECchr723469989Missense_MutationnovelF41C0.29
UCECchr723345977Frame_Shift_DelNAI302Lfs*170.16
UCECchr7234701295'UTRrs7743769890.42
UCECchr7233119293'UTRnovel0.32
UCECchr723415340Intronnovel0.43
UCECchr723415229Intronnovel0.42
UCECchr723415311Intronnovel0.34
UCECchr7233123323'UTRnovel0.19
UCECchr723317704Missense_MutationnovelA444T0.35
UCECchr723415080Intronnovel0.09
UCECchr723313641Missense_MutationNAI470L0.46
UCECchr723313631Missense_MutationNAK473T0.36
UCECchr7233122913'UTRnovel0.28
UCECchr723347708Missense_Mutationrs202212306A237V0.48
UCECchr723351532SilentnovelA152A0.28
UCECchr7233117503'UTRnovel0.48
UCECchr723415282Intronnovel0.41
UCECchr7233117513'UTRnovel0.24
UCECchr7233114183'UTRnovel0.18
UCECchr723347708Missense_Mutationrs202212306A237V0.31
UCECchr723361738Missense_MutationnovelL97M0.34KH_1
UCECchr723414872Intronnovel0.19
UCECchr723319243Silentrs768566146T405T0.41
UCECchr723347632Missense_MutationnovelE262D0.4
UCECchr723351476Missense_Mutationrs370236925R171H0.33
UCECchr723351578Missense_MutationnovelD137G0.36KH_1
UCSchr723351541SilentnovelL149L0.33
UCSchr723347680Silentrs751315844I246I0.34

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCAMP0.53330.24436
CESCAMP0.11530.0058042
LGGAMP0.20080.19963
LUADAMP0.45540.17291
PAADAMP0.18480.20695
PAADDEL0.00540.13216
PRADAMP0.14430.02772
THCADEL0.0020.27619

Survival Analysis
CancerP-value Q-value
KIRC0.00011

Kaplan-Meier Survival Analysis

SARC0.00044

Kaplan-Meier Survival Analysis

MESO0.00011

Kaplan-Meier Survival Analysis

ACC0.0082

Kaplan-Meier Survival Analysis

HNSC0.047

Kaplan-Meier Survival Analysis

LUSC0.037

Kaplan-Meier Survival Analysis

COAD0.047

Kaplan-Meier Survival Analysis

PAAD0.0001

Kaplan-Meier Survival Analysis

BLCA0.0032

Kaplan-Meier Survival Analysis

LAML0.00057

Kaplan-Meier Survival Analysis

KICH0.019

Kaplan-Meier Survival Analysis

UCEC0.0085

Kaplan-Meier Survival Analysis

LIHC0.01

Kaplan-Meier Survival Analysis

THCA0.013

Kaplan-Meier Survival Analysis

LUAD0.0014

Kaplan-Meier Survival Analysis

UVM0.0041

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBDs
  • RBPome
  • PRI
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Paralogs
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000136231 (Gene tree)
Gene ID
10643
Gene Symbol
IGF2BP3
Alias
IMP-3|CT98|IMP3
Full Name
insulin like growth factor 2 mRNA binding protein 3
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
160,319 bases
Position
chr7:23,310,209-23,470,527
Accession
28868
RBP type
canonical RBP
Summary
The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000258729KH_1PF00013.292.4e-5614
ENSP00000258729KH_1PF00013.292.4e-5624
ENSP00000258729KH_1PF00013.292.4e-5634
ENSP00000258729KH_1PF00013.292.4e-5644
ENSP00000480267KH_1PF00013.298.8e-2812
ENSP00000480267KH_1PF00013.298.8e-2822
ENSP00000258729RRM_1PF00076.221e-1712
ENSP00000258729RRM_1PF00076.221e-1722
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8
Protein-RNA interaction(RNA-Binding Site)
Click here to download all RNA binding sites

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
22465430Igf2bp1 is required for full induction of Ptgs2 mRNA in colonic mesenchymal stem cells in mice.Gastroenterology2012 JulManieri NAdoi: 10.1053/j.gastro.2012.03.037
18547613Expression of RNA-binding protein IMP3 (KOC) in benign urothelium and urothelial tumors.Hum Pathol2008 AugLi Ldoi: 10.1016/j.humpath.2007.12.012
21838610Insulin-like growth factor II-messenger RNA-binding protein-3 and lung cancer.Biotech Histochem2012 JanFindeis-Hosey JJdoi: 10.3109/10520295.2011.591831
31118463Combinatorial recognition of clustered RNA elements by the multidomain RNA-binding protein IMP3.Nat Commun2019 May 22Schneider Tdoi: 10.1038/s41467-019-09769-8.
22536444PKCα binds G3BP2 and regulates stress granule formation following cellular stress.PLoS One2012Kobayashi Tdoi: 10.1371/journal.pone.0035820
20178612Insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) overexpression in pancreatic ductal adenocarcinoma correlates with poor survival.BMC Cancer2010 Feb 23Schaeffer DFdoi: 10.1186/1471-2407-10-59.
29212181Insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) promotes lung tumorigenesis via attenuating p53 stability.Oncotarget2017 Sep 27Zhao Wdoi: 10.18632/oncotarget.21280
23640942Subcellular localization and RNP formation of IGF2BPs (IGF2 mRNA-binding proteins) is modulated by distinct RNA-binding domains.Biol Chem2013 AugWachter Kdoi: 10.1515/hsz-2013-0111.
28481226Neonatal expression of RNA-binding protein IGF2BP3 regulates the human fetal-adult megakaryocyte transition.J Clin Invest2017 Jun 1Elagib KEdoi: 10.1172/JCI88936
30135093Structural basis of IMP3 RRM12 recognition of RNA.RNA2018 DecJia Mdoi: 10.1261/rna.065649.118
16049158Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer.Reproduction2005 AugHammer NA-
23069990Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression?Cell Mol Life Sci2013 AugBell JLdoi: 10.1007/s00018-012-1186-z
19357927Diffuse expression of RNA-binding protein IMP3 predicts high-stage lymph node metastasis and poor prognosis in colorectal adenocarcinoma.Ann Surg Oncol2009 JunYuan RHdoi: 10.1245/s10434-009-0446-0
19192721Expression of insulin-like growth factor-II mRNA binding protein 3 (IMP3) in osteosarcoma.Oncol Res2008Do SI-
18802962RNA-binding protein insulin-like growth factor II mRNA-binding protein 3 expression promotes tumor invasion and predicts early recurrence and poor prognosis in hepatocellular carcinoma.Hepatology2008 OctJeng YMdoi: 10.1002/hep.22459.
18499984Use of IMP3 in identification of carcinoma in fine needle aspiration biopsies of pancreas.Acta Cytol2008 Mar-AprYantiss RK-
21757716RNA-binding protein insulin-like growth factor mRNA-binding protein 3 (IMP-3) promotes cell survival via insulin-like growth factor II signaling after ionizing radiation.J Biol Chem2011 Sep 9Liao Bdoi: 10.1074/jbc.M111.263913
23246869Expression of insulin-like growth factor II mRNA-binding protein 3 predicts early recurrence and poor prognosis in intrahepatic cholangiocarcinoma.Int J Surg2013Chen YLdoi: 10.1016/j.ijsu.2012.11.021
24135846Expression of insulin-like growth factor II mRNA-binding protein 3 (IMP3) in sacral chordoma.J Neurooncol2014 JanZhou Mdoi: 10.1007/s11060-013-1274-4
23647076Insulin-like growth factor II mRNA-binding protein 3 expression promotes tumor formation and invasion and predicts poor prognosis in oral squamous cell carcinoma.J Oral Pathol Med2011 OctLin CYdoi: 10.1111/j.1600-0714.2011.01019.x
27510448CircRNA-protein complexes: IMP3 protein component defines subfamily of circRNPs.Sci Rep2016 Aug 11Schneider Tdoi: 10.1038/srep31313.
26796627Insulin-Like Growth Factor II mRNA-Binding Protein 3 Expression Correlates with Poor Prognosis in Acral Lentiginous Melanoma.PLoS One2016 Jan 21Sheen YSdoi: 10.1371/journal.pone.0147431
25794352RELB Alters Proliferation of Human Pluripotent Stem Cells via IMP3- and LIN28-Mediated Modulation of the Expression of IGF2 and Other Cell-Cycle Regulators.Stem Cells Dev2015 Aug 15Thakar NYdoi: 10.1089/scd.2014.0587
28465487IGF2 mRNA binding protein 3 (IMP3) promotes glioma cell migration by enhancing the translation of RELA/p65.Oncotarget2017 Jun 20Bhargava Sdoi: 10.18632/oncotarget.17118.
12806623Transgenic overexpression of the oncofetal RNA binding protein KOC leads to remodeling of the exocrine pancreas.Gastroenterology2003 JunWagner M-
11713986A family of IGF-II mRNA binding proteins (IMP) involved in RNA trafficking.Scand J Clin Lab Invest Suppl2001Nielsen FC-
11465943Autoimmune responses to mRNA binding proteins p62 and Koc in diverse malignancies.Clin Immunol2001 AugZhang JY-
15753088The RNA-binding protein IMP-3 is a translational activator of insulin-like growth factor II leader-3 mRNA during proliferation of human K562 leukemia cells.J Biol Chem2005 May 6Liao B-
15601260VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins.Biol Cell2005 JanYisraeli JK-
16814207Analysis of RNA-binding protein IMP3 to predict metastasis and prognosis of renal-cell carcinoma: a retrospective study.Lancet Oncol2006 JulJiang Z-
20060157IMP3/L523S, a novel immunocytochemical marker that distinguishes benign and malignant cells: the expression profiles of IMP3/L523S in effusion cytology.Hum Pathol2010 MayIkeda Kdoi: 10.1016/j.humpath.2009.04.030
18835627Merkel cell carcinoma expresses K homology domain-containing protein overexpressed in cancer similar to other high-grade neuroendocrine carcinomas.Hum Pathol2009 FebPryor JGdoi: 10.1016/j.humpath.2008.07.009
17521698Extrapulmonary small cell carcinomas express K homology domain containing protein overexpressed in cancer, but carcinoid tumors do not.Hum Pathol2007 AugSimon R-
22840368Insulin-like growth factor 2 messenger RNA binding protein 3 (IGF2BP3) is a marker of unfavourable prognosis in colorectal cancer.Eur J Cancer2012 DecLochhead Pdoi: 10.1016/j.ejca.2012.06.021
22646265Reevaluation and identification of the best immunohistochemical panel (pVHL, Maspin, S100P, IMP-3) for ductal adenocarcinoma of the pancreas.Arch Pathol Lab Med2012 JunLiu Hdoi: 10.5858/arpa.2011-0326-OA.
21809995The oncofetal protein IMP3: a novel molecular marker to predict aggressive meningioma.Arch Pathol Lab Med2011 AugHao Sdoi: 10.5858/2009-0652-OAR2.
21613208Insulin growth factor-2 binding protein 3 (IGF2BP3) is a glioblastoma-specific marker that activates phosphatidylinositol 3-kinase/mitogen-activated protein kinase (PI3K/MAPK) pathways by modulating IGF-2.J Biol Chem2011 Jul 22Suvasini Rdoi: 10.1074/jbc.M110.178012
25499221KIF20A-mediated RNA granule transport system promotes the invasiveness of pancreatic cancer cells.Neoplasia2014 DecTaniuchi Kdoi: 10.1016/j.neo.2014.10.007.
24713990Oncofetal protein IMP3, a new cancer biomarker.Adv Anat Pathol2014 MayGong Ydoi: 10.1097/PAP.0000000000000021.
24615121Prognostic value of tissue and circulating levels of IMP3 in prostate cancer.Int J Cancer2014 Oct 1Szarvas Tdoi: 10.1002/ijc.28808
24411949Insulin-like growth factor II messenger RNA-binding protein 3 expression in gastrointestinal mesenchymal tumors.Hum Pathol2014 MarYamamoto Hdoi: 10.1016/j.humpath.2013.10.010
24388440Insulin-like growth factor messenger RNA-binding protein 3 expression helps prognostication in patients with upper tract urothelial carcinoma.Eur Urol2014 AugLee DJdoi: 10.1016/j.eururo.2013.12.008
24343741Comparative immunohistochemical analysis of IMP3, GLUT1, EMA, CD146, and desmin for distinguishing malignant mesothelioma from reactive mesothelial cells.Am J Clin Pathol2014 JanMinato Hdoi: 10.1309/AJCP5KNL7QTELLYI.
23808460Clinical implications of current developments in genitourinary pathology.Arch Pathol Lab Med2013 JulZhou AGdoi: 10.5858/arpa.2012-0210-RA.
23597774Insulin-like growth factor II messenger RNA-binding protein-3 is a valuable diagnostic and prognostic marker of intraductal papillary mucinous neoplasm.Hum Pathol2013 SepMorimatsu Kdoi: 10.1016/j.humpath.2012.12.020
23465280Expression of the oncofetal protein IGF2BP3 in endometrial clear cell carcinoma: assessment of frequency and significance.Hum Pathol2013 AugFadare Odoi: 10.1016/j.humpath.2012.12.003
26982091The RNA binding protein IMP3 facilitates tumor immune escape by downregulating the stress-induced ligands ULPB2 and MICB.Elife2016 Mar 16Schmiedel Ddoi: 10.7554/eLife.13426.
26974154RNA-binding protein IGF2BP3 targeting of oncogenic transcripts promotes hematopoietic progenitor proliferation.J Clin Invest2016 Apr 1Palanichamy JKdoi: 10.1172/JCI80046
26379850Diagnostic value of IMP3 in pancreatic cancer: a meta-analysis.Int J Clin Exp Med2015 Jul 15Wang Q-
26158423Overexpression of the RNA-binding proteins Lin28B and IGF2BP3 (IMP3) is associated with chemoresistance and poor disease outcome in ovarian cancer.Br J Cancer2015 Jul 28Hsu KFdoi: 10.1038/bjc.2015.254
28381175Expression profile, clinical significance, and biological function of insulin-like growth factor 2 messenger RNA-binding proteins in non-small cell lung cancer.Tumour Biol2017 AprShi Rdoi: 10.1177/1010428317695928.
27900001Expression of glucose transporter-1 is correlated with hypoxia-inducible factor 1α and malignant potential in pancreatic neuroendocrine tumors.Oncol Lett2016 NovFujino M-
29077232Insulin-like growth factor II messenger RNA-binding protein-3 is an independent prognostic factor in uterine leiomyosarcoma.Histopathology2018 AprYasutake Ndoi: 10.1111/his.13422
29114069BAG3 directly stabilizes Hexokinase 2 mRNA and promotes aerobic glycolysis in pancreatic cancer cells.J Cell Biol2017 Dec 4An MXdoi: 10.1083/jcb.201701064
27438513IMP3 Immunohistochemical Expression Remains Consistent Among All Grades of Gastrointestinal Neuroendocrine Tumors.Appl Immunohistochem Mol Morphol2018 AprAgostini-Vulaj Ddoi: 10.1097/PAI.0000000000000416.
29703820Insulin-Like Growth Factor 2 mRNA-Binding Protein 3 is a Novel Post-Transcriptional Regulator of Ewing Sarcoma Malignancy.Clin Cancer Res2018 Aug 1Mancarella Cdoi: 10.1158/1078-0432.CCR-17-2602
30098092Measurement of telomere length in cells from pleural effusion: Asbestos exposure causes telomere shortening in pleural mesothelial cells.Pathol Int2018 SepAida Sdoi: 10.1111/pin.12710
30670575Dysregulated activation of fetal liver programme in acute liver failure.Gut2019 JunHyun Jdoi: 10.1136/gutjnl-2018-317603
30895618Increased IGF2BP3 expression promotes the aggressive phenotypes of colorectal cancer cells in vitro and vivo.J Cell Physiol2019 AugXu Wdoi: 10.1002/jcp.28483
30951723Loss of Gsdf leads to a dysregulation of Igf2bp3-mediated oocyte development in medaka.Gen Comp Endocrinol2019 Jun 1Wu Xdoi: 10.1016/j.ygcen.2019.04.001
31277094IMP3 is a biomarker for non-muscle-invasive urothelial carcinoma of the bladder associated with an aggressive phenotype.Medicine (Baltimore)2019 JulYang Fdoi: 10.1097/MD.0000000000016009.
30797711Blockade of miR-3614 maturation by IGF2BP3 increases TRIM25 expression and promotes breast cancer cell proliferation.EBioMedicine2019 MarWang Zdoi: 10.1016/j.ebiom.2018.12.061
19734845Diagnostic utility of IMP3 in segregating metastatic melanoma from benign nevi in lymph nodes.Mod Pathol2009 DecMentrikoski MJdoi: 10.1038/modpathol.2009.128
18204432IMP-3 is a novel progression marker in malignant melanoma.Mod Pathol2008 AprPryor JGdoi: 10.1038/modpathol.3801016
30243807The expression and biological information analysis of miR-375-3p in head and neck squamous cell carcinoma based on 1825 samples from GEO, TCGA, and peer-reviewed publications.Pathol Res Pract2018 NovCen WNdoi: 10.1016/j.prp.2018.09.010
19698973IMP-3 is differentially expressed in normal and neoplastic lymphoid tissue.Hum Pathol2009 DecKing RLdoi: 10.1016/j.humpath.2009.05.003
22012575Oncofetal protein, IMP-3, a potential marker for prediction of postoperative peritoneal dissemination in gastric adenocarcinoma.J Surg Oncol2012 Jun 15Okada Kdoi: 10.1002/jso.22108
25176620IMP3 expression is associated with poor survival in cervical squamous cell carcinoma.Hum Pathol2014 NovWei Qdoi: 10.1016/j.humpath.2014.07.006
23845468IMP3 as a supplemental diagnostic marker for Hodgkin lymphoma.Hum Pathol2013 OctTang Hdoi: 10.1016/j.humpath.2013.04.011
26624896Positive Surgical Margin, HPV Persistence, and Expression of Both TPX2 and PD-L1 Are Associated with Persistence/Recurrence of Cervical Intraepithelial Neoplasia after Cervical Conization.PLoS One2015 Dec 1Zhang Hdoi: 10.1371/journal.pone.0142868
29731738Insulin-Like Growth Factor 2 mRNA-Binding Protein 3 Influences Sensitivity to Anti-IGF System Agents Through the Translational Regulation of IGF1R.Front Endocrinol (Lausanne)2018 Apr 20Mancarella Cdoi: 10.3389/fendo.2018.00178
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000619562IGF2BP3-2182126-ENSP00000480267198 (aa)-O00425
ENST00000497563IGF2BP3-216657--- (aa)--
ENST00000498363IGF2BP3-217529--- (aa)--
ENST00000421467IGF2BP3-2022988-ENSP0000039593681 (aa)-F8WD15
ENST00000467592IGF2BP3-205600--- (aa)--
ENST00000465058IGF2BP3-203534--- (aa)--
ENST00000479504IGF2BP3-211559--- (aa)--
ENST00000476938IGF2BP3-210500--- (aa)--
ENST00000258729IGF2BP3-2014250XM_006715639ENSP00000258729579 (aa)XP_006715702O00425
ENST00000480547IGF2BP3-212596--- (aa)--
ENST00000468005IGF2BP3-2062948--- (aa)--
ENST00000492771IGF2BP3-214564--- (aa)--
ENST00000491719IGF2BP3-213800--- (aa)--
ENST00000474105IGF2BP3-209663--- (aa)--
ENST00000468263IGF2BP3-207706--- (aa)--
ENST00000466809IGF2BP3-204588--- (aa)--
ENST00000495009IGF2BP3-215452--- (aa)--
ENST00000469723IGF2BP3-208556--- (aa)--
Gene Model
Click here to download ENSG00000136231's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000136231Body Mass Index4.5725990E-005-
ENSG00000136231Body Mass Index5.0777281E-005-
ENSG00000136231Body Height2E-1420881960
ENSG00000136231Hip2E-825673412
ENSG00000136231Body Mass Index2E-825673412
ENSG00000136231Body Height4E-2625282103
ENSG00000136231Body Height5E-1023563607
ENSG00000136231Personality5E-623903073
ENSG00000136231Hip1E-825673412
ENSG00000136231Body Mass Index1E-825673412
ENSG00000136231Body Height8E-825281659
ENSG00000136231Immunoglobulins2E-623382691
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000136231rs11765649723439394TBirth weight27680694[0.018-0.034] unit increase0.0258EFO_0004344
ENSG00000136231rs12534093723463355AHeight20881960[NR] unit decrease0.034EFO_0004339
ENSG00000136231rs12534093723463355AInfant length25281659[0.040-0.088] unit decrease0.064EFO_0006785
ENSG00000136231rs11763760723440848CIgG glycosylation23382691[0.11-0.26] unit decrease0.1815EFO_0005193
ENSG00000136231rs6957923723443066GHeight23563607[NR]1.14EFO_0004339
ENSG00000136231rs375092723381148CPersonality dimensions23903073[-0.078-0.118] unit increase0.02EFO_0004365
ENSG00000136231rs11769806723440513?General cognitive ability29844566z-score increase4.526EFO_0004337
ENSG00000136231rs118003225723469676?Lung function (FVC)30595370EFO_0004312
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000136231's network

* RBP PPI network refers to all genes directly bind to RBP
Paralogs
Ensembl IDGene SymbolCoverageIdentiy ParalogGene SymbolCoverageIdentiy
ENSG00000136231IGF2BP310072.899ENSG00000159217IGF2BP110073.846
ENSG00000136231IGF2BP35231.250ENSG00000088247KHSRP9531.250
ENSG00000136231IGF2BP36130.400ENSG00000197111PCBP29630.400
ENSG00000136231IGF2BP39665.530ENSG00000073792IGF2BP29865.144
ENSG00000136231IGF2BP38331.176ENSG00000183570PCBP39231.176
ENSG00000136231IGF2BP36132.800ENSG00000162613FUBP15332.800
ENSG00000136231IGF2BP38630.570ENSG00000139910NOVA16232.979
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000136231IGF2BP39866.958ENSAPOG00000007660igf2bp19467.657Acanthochromis_polyacanthus
ENSG00000136231IGF2BP310075.500ENSAPOG00000017377igf2bp310075.214Acanthochromis_polyacanthus
ENSG00000136231IGF2BP3100100.000ENSAMEG00000003485IGF2BP310098.273Ailuropoda_melanoleuca
ENSG00000136231IGF2BP38778.613ENSACIG00000013204igf2bp19667.298Amphilophus_citrinellus
ENSG00000136231IGF2BP39982.022ENSACIG00000001392igf2bp310074.359Amphilophus_citrinellus
ENSG00000136231IGF2BP39866.960ENSAOCG00000014106igf2bp19467.663Amphiprion_ocellaris
ENSG00000136231IGF2BP39972.500ENSAOCG00000015477-9972.500Amphiprion_ocellaris
ENSG00000136231IGF2BP39779.891ENSAOCG00000015936igf2bp39975.670Amphiprion_ocellaris
ENSG00000136231IGF2BP39866.960ENSAPEG00000021612igf2bp19467.663Amphiprion_percula
ENSG00000136231IGF2BP310075.000ENSAPEG00000018592igf2bp310075.000Amphiprion_percula
ENSG00000136231IGF2BP39877.551ENSATEG00000000681igf2bp39675.588Anabas_testudineus
ENSG00000136231IGF2BP39970.141ENSATEG00000009316igf2bp19570.141Anabas_testudineus
ENSG00000136231IGF2BP39987.778ENSAPLG00000013290IGF2BP310085.445Anas_platyrhynchos
ENSG00000136231IGF2BP39985.946ENSACAG00000013538IGF2BP310084.247Anolis_carolinensis
ENSG00000136231IGF2BP310096.296ENSANAG00000029824-10096.296Aotus_nancymaae
ENSG00000136231IGF2BP310098.990ENSANAG00000022059IGF2BP310098.791Aotus_nancymaae
ENSG00000136231IGF2BP39876.744ENSACLG00000003652igf2bp19376.744Astatotilapia_calliptera
ENSG00000136231IGF2BP39980.328ENSACLG00000000050igf2bp310074.450Astatotilapia_calliptera
ENSG00000136231IGF2BP39979.899ENSAMXG00000007453igf2bp310075.211Astyanax_mexicanus
ENSG00000136231IGF2BP39974.138ENSAMXG00000015877igf2bp19674.439Astyanax_mexicanus
ENSG00000136231IGF2BP310098.492ENSBTAG00000019406IGF2BP310097.586Bos_taurus
ENSG00000136231IGF2BP310099.495ENSCJAG00000001499IGF2BP310099.309Callithrix_jacchus
ENSG00000136231IGF2BP3100100.000ENSCAFG00000002766IGF2BP310098.618Canis_familiaris
ENSG00000136231IGF2BP3100100.000ENSCAFG00020002709IGF2BP310098.618Canis_lupus_dingo
ENSG00000136231IGF2BP310098.995ENSCHIG00000025829IGF2BP310097.414Capra_hircus
ENSG00000136231IGF2BP310099.495ENSTSYG00000012668IGF2BP310099.136Carlito_syrichta
ENSG00000136231IGF2BP39177.778ENSCAPG00000004374IGF2BP38584.807Cavia_aperea
ENSG00000136231IGF2BP310098.990ENSCPOG00000015070IGF2BP310098.269Cavia_porcellus
ENSG00000136231IGF2BP310099.495ENSCCAG00000027687IGF2BP310099.309Cebus_capucinus
ENSG00000136231IGF2BP3100100.000ENSCATG00000036018IGF2BP310099.827Cercocebus_atys
ENSG00000136231IGF2BP3100100.000ENSCLAG00000009835IGF2BP310098.791Chinchilla_lanigera
ENSG00000136231IGF2BP310099.495ENSCSAG00000014023IGF2BP310099.793Chlorocebus_sabaeus
ENSG00000136231IGF2BP310099.495ENSCHOG00000002341IGF2BP310089.119Choloepus_hoffmanni
ENSG00000136231IGF2BP310084.247ENSCPBG00000022464IGF2BP310084.760Chrysemys_picta_bellii
ENSG00000136231IGF2BP3100100.000ENSCANG00000036199IGF2BP310099.655Colobus_angolensis_palliatus
ENSG00000136231IGF2BP310098.485ENSCGRG00001011804Igf2bp310095.682Cricetulus_griseus_chok1gshd
ENSG00000136231IGF2BP310098.485ENSCGRG00000005626Igf2bp310096.538Cricetulus_griseus_crigri
ENSG00000136231IGF2BP39968.750ENSCSEG00000013968igf2bp19567.895Cynoglossus_semilaevis
ENSG00000136231IGF2BP39080.368ENSCSEG00000012106igf2bp310070.884Cynoglossus_semilaevis
ENSG00000136231IGF2BP39081.461ENSCVAG00000008891igf2bp310066.497Cyprinodon_variegatus
ENSG00000136231IGF2BP39667.949ENSCVAG00000018051igf2bp19462.681Cyprinodon_variegatus
ENSG00000136231IGF2BP39984.270ENSDARG00000010266igf2bp310077.055Danio_rerio
ENSG00000136231IGF2BP39974.611ENSDARG00000061478igf2bp19674.355Danio_rerio
ENSG00000136231IGF2BP310098.990ENSDNOG00000013164IGF2BP310098.341Dasypus_novemcinctus
ENSG00000136231IGF2BP3100100.000ENSDORG00000014185Igf2bp310098.273Dipodomys_ordii
ENSG00000136231IGF2BP39982.524ENSETEG00000015568IGF2BP310090.822Echinops_telfairi
ENSG00000136231IGF2BP39670.513ENSEBUG00000013440-9860.672Eptatretus_burgeri
ENSG00000136231IGF2BP39969.543ENSEBUG00000012796IGF2BP39965.820Eptatretus_burgeri
ENSG00000136231IGF2BP37960.510ENSEBUG00000005932-9052.475Eptatretus_burgeri
ENSG00000136231IGF2BP3100100.000ENSEASG00005021998IGF2BP310098.100Equus_asinus_asinus
ENSG00000136231IGF2BP3100100.000ENSECAG00000016797IGF2BP310098.100Equus_caballus
ENSG00000136231IGF2BP38891.489ENSEEUG00000004707IGF2BP38891.489Erinaceus_europaeus
ENSG00000136231IGF2BP39878.421ENSELUG00000005947igf2bp39973.045Esox_lucius
ENSG00000136231IGF2BP39873.592ENSELUG00000014974igf2bp19570.238Esox_lucius
ENSG00000136231IGF2BP3100100.000ENSFCAG00000030786IGF2BP310098.618Felis_catus
ENSG00000136231IGF2BP39987.293ENSFALG00000009615IGF2BP310084.178Ficedula_albicollis
ENSG00000136231IGF2BP3100100.000ENSFDAG00000008156IGF2BP310098.446Fukomys_damarensis
ENSG00000136231IGF2BP38880.392ENSFHEG00000000844igf2bp19972.101Fundulus_heteroclitus
ENSG00000136231IGF2BP39980.541ENSFHEG00000015920igf2bp310073.480Fundulus_heteroclitus
ENSG00000136231IGF2BP39871.025ENSGMOG00000019381igf2bp19971.378Gadus_morhua
ENSG00000136231IGF2BP39666.667ENSGMOG00000013764igf2bp38672.374Gadus_morhua
ENSG00000136231IGF2BP39987.778ENSGALG00000010961IGF2BP310085.274Gallus_gallus
ENSG00000136231IGF2BP38884.416ENSGAFG00000017992igf2bp39269.905Gambusia_affinis
ENSG00000136231IGF2BP39076.536ENSGAFG00000006445igf2bp19573.423Gambusia_affinis
ENSG00000136231IGF2BP39674.359ENSGACG00000006894igf2bp39967.925Gasterosteus_aculeatus
ENSG00000136231IGF2BP39872.968ENSGACG00000005318igf2bp19872.438Gasterosteus_aculeatus
ENSG00000136231IGF2BP39682.051ENSGAGG00000005791-10082.278Gopherus_agassizii
ENSG00000136231IGF2BP39673.077ENSGAGG00000018500-10073.418Gopherus_agassizii
ENSG00000136231IGF2BP39088.889ENSGAGG00000005787-9082.623Gopherus_agassizii
ENSG00000136231IGF2BP310093.827ENSGGOG00000041475-10093.827Gorilla_gorilla
ENSG00000136231IGF2BP3100100.000ENSGGOG00000010286IGF2BP3100100.000Gorilla_gorilla
ENSG00000136231IGF2BP39871.002ENSHBUG00000009868igf2bp19574.094Haplochromis_burtoni
ENSG00000136231IGF2BP310075.169ENSHBUG00000018217igf2bp310074.536Haplochromis_burtoni
ENSG00000136231IGF2BP310099.495ENSHGLG00000013075IGF2BP310098.273Heterocephalus_glaber_female
ENSG00000136231IGF2BP310099.495ENSHGLG00100010458IGF2BP310098.273Heterocephalus_glaber_male
ENSG00000136231IGF2BP310075.377ENSHCOG00000000578igf2bp310069.244Hippocampus_comes
ENSG00000136231IGF2BP39874.956ENSIPUG00000002561igf2bp19575.439Ictalurus_punctatus
ENSG00000136231IGF2BP310079.293ENSIPUG00000006070igf2bp310073.658Ictalurus_punctatus
ENSG00000136231IGF2BP310099.495ENSSTOG00000008519IGF2BP310098.964Ictidomys_tridecemlineatus
ENSG00000136231IGF2BP310099.495ENSJJAG00000011174Igf2bp310097.582Jaculus_jaculus
ENSG00000136231IGF2BP39873.286ENSKMAG00000016694igf2bp19572.408Kryptolebias_marmoratus
ENSG00000136231IGF2BP39882.123ENSKMAG00000019838igf2bp310074.786Kryptolebias_marmoratus
ENSG00000136231IGF2BP39380.791ENSLBEG00000005339igf2bp39874.520Labrus_bergylta
ENSG00000136231IGF2BP39973.137ENSLBEG00000022004igf2bp19572.617Labrus_bergylta
ENSG00000136231IGF2BP38978.235ENSLACG00000016755igf2bp110073.715Latimeria_chalumnae
ENSG00000136231IGF2BP39886.034ENSLACG00000012967IGF2BP310076.923Latimeria_chalumnae
ENSG00000136231IGF2BP39886.111ENSLOCG00000011599igf2bp310076.898Lepisosteus_oculatus
ENSG00000136231IGF2BP39676.292ENSLOCG00000013497igf2bp19674.871Lepisosteus_oculatus
ENSG00000136231IGF2BP310099.497ENSLAFG00000011924IGF2BP310098.763Loxodonta_africana
ENSG00000136231IGF2BP3100100.000ENSMFAG00000002935IGF2BP310099.827Macaca_fascicularis
ENSG00000136231IGF2BP3100100.000ENSMMUG00000004839-100100.000Macaca_mulatta
ENSG00000136231IGF2BP3100100.000ENSMNEG00000029494IGF2BP310099.827Macaca_nemestrina
ENSG00000136231IGF2BP3100100.000ENSMLEG00000003021IGF2BP310099.827Mandrillus_leucophaeus
ENSG00000136231IGF2BP39875.214ENSMAMG00000001461igf2bp19475.783Mastacembelus_armatus
ENSG00000136231IGF2BP39782.682ENSMAMG00000008545igf2bp310071.380Mastacembelus_armatus
ENSG00000136231IGF2BP39876.744ENSMZEG00005023128igf2bp19376.744Maylandia_zebra
ENSG00000136231IGF2BP39085.535ENSMZEG00005009164igf2bp310074.324Maylandia_zebra
ENSG00000136231IGF2BP39987.778ENSMGAG00000010497IGF2BP310085.199Meleagris_gallopavo
ENSG00000136231IGF2BP310098.485ENSMAUG00000001831Igf2bp310095.682Mesocricetus_auratus
ENSG00000136231IGF2BP3100100.000ENSMICG00000013683IGF2BP310099.482Microcebus_murinus
ENSG00000136231IGF2BP310097.980ENSMOCG00000001740Igf2bp310095.337Microtus_ochrogaster
ENSG00000136231IGF2BP39981.921ENSMMOG00000020177igf2bp310072.743Mola_mola
ENSG00000136231IGF2BP39970.486ENSMMOG00000005518igf2bp19670.660Mola_mola
ENSG00000136231IGF2BP39679.487ENSMODG00000001014IGF2BP39373.984Monodelphis_domestica
ENSG00000136231IGF2BP39875.291ENSMALG00000001750igf2bp19375.291Monopterus_albus
ENSG00000136231IGF2BP310074.829ENSMALG00000020896igf2bp310074.099Monopterus_albus
ENSG00000136231IGF2BP310098.990MGP_CAROLIEiJ_G0028364Igf2bp310096.718Mus_caroli
ENSG00000136231IGF2BP310098.485ENSMUSG00000029814Igf2bp310096.546Mus_musculus
ENSG00000136231IGF2BP310099.495MGP_PahariEiJ_G0022114Igf2bp310096.891Mus_pahari
ENSG00000136231IGF2BP310098.485MGP_SPRETEiJ_G0029367Igf2bp310096.546Mus_spretus
ENSG00000136231IGF2BP310099.495ENSMPUG00000013527IGF2BP310098.100Mustela_putorius_furo
ENSG00000136231IGF2BP310089.091ENSMLUG00000008451IGF2BP310093.307Myotis_lucifugus
ENSG00000136231IGF2BP3100100.000ENSNGAG00000023578Igf2bp310097.927Nannospalax_galili
ENSG00000136231IGF2BP39975.568ENSNBRG00000009346igf2bp19575.568Neolamprologus_brichardi
ENSG00000136231IGF2BP39980.328ENSNBRG00000005961igf2bp310066.667Neolamprologus_brichardi
ENSG00000136231IGF2BP310085.542ENSNLEG00000034042-10078.929Nomascus_leucogenys
ENSG00000136231IGF2BP3100100.000ENSNLEG00000014780IGF2BP310097.952Nomascus_leucogenys
ENSG00000136231IGF2BP39577.922ENSMEUG00000012510IGF2BP38080.556Notamacropus_eugenii
ENSG00000136231IGF2BP39099.438ENSOPRG00000010494IGF2BP310081.400Ochotona_princeps
ENSG00000136231IGF2BP391100.000ENSODEG00000011195-9695.911Octodon_degus
ENSG00000136231IGF2BP310092.593ENSODEG00000009085-10092.593Octodon_degus
ENSG00000136231IGF2BP310074.454ENSONIG00000004506igf2bp310073.826Oreochromis_niloticus
ENSG00000136231IGF2BP39972.241ENSONIG00000006205igf2bp19673.103Oreochromis_niloticus
ENSG00000136231IGF2BP310084.812ENSOANG00000014203IGF2BP310085.324Ornithorhynchus_anatinus
ENSG00000136231IGF2BP39596.296ENSOCUG00000008976IGF2BP39996.552Oryctolagus_cuniculus
ENSG00000136231IGF2BP39872.583ENSORLG00000025629igf2bp19472.583Oryzias_latipes
ENSG00000136231IGF2BP39083.832ENSORLG00000004712igf2bp310075.510Oryzias_latipes
ENSG00000136231IGF2BP39872.583ENSORLG00020018835igf2bp19472.583Oryzias_latipes_hni
ENSG00000136231IGF2BP39785.714ENSORLG00020003562igf2bp310074.746Oryzias_latipes_hni
ENSG00000136231IGF2BP39872.408ENSORLG00015011181igf2bp19472.408Oryzias_latipes_hsok
ENSG00000136231IGF2BP39083.832ENSORLG00015015563igf2bp310075.468Oryzias_latipes_hsok
ENSG00000136231IGF2BP39876.163ENSOMEG00000012285igf2bp19376.163Oryzias_melastigma
ENSG00000136231IGF2BP39082.081ENSOMEG00000017916igf2bp310075.128Oryzias_melastigma
ENSG00000136231IGF2BP3100100.000ENSOGAG00000017159IGF2BP310099.655Otolemur_garnettii
ENSG00000136231IGF2BP310099.495ENSOARG00000012961IGF2BP310097.582Ovis_aries
ENSG00000136231IGF2BP39691.026ENSPPAG00000038016-10070.564Pan_paniscus
ENSG00000136231IGF2BP3100100.000ENSPPAG00000033809IGF2BP3100100.000Pan_paniscus
ENSG00000136231IGF2BP3100100.000ENSPPRG00000018062IGF2BP310098.618Panthera_pardus
ENSG00000136231IGF2BP3100100.000ENSPTIG00000006021IGF2BP310098.618Panthera_tigris_altaica
ENSG00000136231IGF2BP3100100.000ENSPTRG00000018986IGF2BP3100100.000Pan_troglodytes
ENSG00000136231IGF2BP39692.308ENSPTRG00000047422-10086.777Pan_troglodytes
ENSG00000136231IGF2BP3100100.000ENSPANG00000020534IGF2BP310099.827Papio_anubis
ENSG00000136231IGF2BP39678.036ENSPKIG00000012340igf2bp39878.571Paramormyrops_kingsleyae
ENSG00000136231IGF2BP39083.117ENSPKIG00000023239igf2bp19566.265Paramormyrops_kingsleyae
ENSG00000136231IGF2BP310081.538ENSPSIG00000014154IGF2BP310083.077Pelodiscus_sinensis
ENSG00000136231IGF2BP39180.864ENSPMGG00000004964igf2bp19465.905Periophthalmus_magnuspinnatus
ENSG00000136231IGF2BP39769.069ENSPMGG00000006092igf2bp39668.804Periophthalmus_magnuspinnatus
ENSG00000136231IGF2BP310098.990ENSPEMG00000023450Igf2bp310096.731Peromyscus_maniculatus_bairdii
ENSG00000136231IGF2BP37568.172ENSPMAG00000003229-10069.414Petromyzon_marinus
ENSG00000136231IGF2BP39465.193ENSPMAG00000005383igf2bp39754.461Petromyzon_marinus
ENSG00000136231IGF2BP39878.984ENSPCIG00000007929IGF2BP39378.109Phascolarctos_cinereus
ENSG00000136231IGF2BP39676.923ENSPFOG00000005971igf2bp310072.504Poecilia_formosa
ENSG00000136231IGF2BP39874.737ENSPFOG00000019586igf2bp19673.657Poecilia_formosa
ENSG00000136231IGF2BP39873.077ENSPLAG00000015205igf2bp19874.503Poecilia_latipinna
ENSG00000136231IGF2BP37586.577ENSPLAG00000009986-9178.191Poecilia_latipinna
ENSG00000136231IGF2BP39676.923ENSPLAG00000007777igf2bp310074.324Poecilia_latipinna
ENSG00000136231IGF2BP39874.737ENSPMEG00000005988igf2bp19673.657Poecilia_mexicana
ENSG00000136231IGF2BP38887.179ENSPMEG00000007820igf2bp310074.155Poecilia_mexicana
ENSG00000136231IGF2BP39874.737ENSPREG00000007009igf2bp19673.657Poecilia_reticulata
ENSG00000136231IGF2BP38887.179ENSPREG00000001808igf2bp310074.450Poecilia_reticulata
ENSG00000136231IGF2BP3100100.000ENSPPYG00000017730IGF2BP310097.755Pongo_abelii
ENSG00000136231IGF2BP37895.946ENSPCAG00000010067IGF2BP38795.946Procavia_capensis
ENSG00000136231IGF2BP3100100.000ENSPCOG00000010110IGF2BP310099.600Propithecus_coquereli
ENSG00000136231IGF2BP39698.718ENSPCOG00000016922-10098.734Propithecus_coquereli
ENSG00000136231IGF2BP3100100.000ENSPVAG00000011295IGF2BP310087.692Pteropus_vampyrus
ENSG00000136231IGF2BP39876.744ENSPNYG00000022740igf2bp19376.744Pundamilia_nyererei
ENSG00000136231IGF2BP39980.328ENSPNYG00000020180igf2bp310066.837Pundamilia_nyererei
ENSG00000136231IGF2BP39673.077ENSPNAG00000015781igf2bp19665.803Pygocentrus_nattereri
ENSG00000136231IGF2BP39983.889ENSPNAG00000000470igf2bp310075.510Pygocentrus_nattereri
ENSG00000136231IGF2BP310099.495ENSRNOG00000009052Igf2bp310096.891Rattus_norvegicus
ENSG00000136231IGF2BP3100100.000ENSRBIG00000033008IGF2BP310099.827Rhinopithecus_bieti
ENSG00000136231IGF2BP3100100.000ENSRROG00000035375IGF2BP310099.827Rhinopithecus_roxellana
ENSG00000136231IGF2BP310099.495ENSSBOG00000019579IGF2BP310099.309Saimiri_boliviensis_boliviensis
ENSG00000136231IGF2BP39678.205ENSSHAG00000006380-10078.481Sarcophilus_harrisii
ENSG00000136231IGF2BP38386.585ENSSHAG00000007163-9274.405Sarcophilus_harrisii
ENSG00000136231IGF2BP39674.194ENSSFOG00015002540igf2bp19672.997Scleropages_formosus
ENSG00000136231IGF2BP39877.971ENSSFOG00015005197igf2bp19477.971Scleropages_formosus
ENSG00000136231IGF2BP39982.222ENSSFOG00015014056igf2bp310077.148Scleropages_formosus
ENSG00000136231IGF2BP38478.443ENSSMAG00000016421igf2bp19068.102Scophthalmus_maximus
ENSG00000136231IGF2BP39878.010ENSSMAG00000014262igf2bp310074.359Scophthalmus_maximus
ENSG00000136231IGF2BP39873.721ENSSDUG00000023380igf2bp19573.721Seriola_dumerili
ENSG00000136231IGF2BP39780.682ENSSDUG00000005535igf2bp310075.171Seriola_dumerili
ENSG00000136231IGF2BP39876.163ENSSLDG00000011912igf2bp19476.163Seriola_lalandi_dorsalis
ENSG00000136231IGF2BP310075.214ENSSLDG00000025576igf2bp310075.214Seriola_lalandi_dorsalis
ENSG00000136231IGF2BP310094.554ENSSARG00000006568IGF2BP310088.550Sorex_araneus
ENSG00000136231IGF2BP39584.477ENSSPUG00000006162IGF2BP39784.657Sphenodon_punctatus
ENSG00000136231IGF2BP39871.178ENSSPAG00000008431igf2bp19671.404Stegastes_partitus
ENSG00000136231IGF2BP39881.921ENSSPAG00000004157igf2bp310066.952Stegastes_partitus
ENSG00000136231IGF2BP3100100.000ENSSSCG00000036695IGF2BP310098.324Sus_scrofa
ENSG00000136231IGF2BP39987.778ENSTGUG00000002773-10085.445Taeniopygia_guttata
ENSG00000136231IGF2BP39667.949ENSTRUG00000020496-9968.354Takifugu_rubripes
ENSG00000136231IGF2BP310073.504ENSTRUG00000006094igf2bp310073.504Takifugu_rubripes
ENSG00000136231IGF2BP39774.336ENSTNIG00000017755igf2bp39973.230Tetraodon_nigroviridis
ENSG00000136231IGF2BP39871.529ENSTNIG00000013986igf2bp19572.056Tetraodon_nigroviridis
ENSG00000136231IGF2BP310078.218ENSTBEG00000001170IGF2BP310078.053Tupaia_belangeri
ENSG00000136231IGF2BP3100100.000ENSTTRG00000008921IGF2BP310098.618Tursiops_truncatus
ENSG00000136231IGF2BP39693.590ENSUAMG00000024553-10093.671Ursus_americanus
ENSG00000136231IGF2BP310093.396ENSUAMG00000021770-9992.857Ursus_americanus
ENSG00000136231IGF2BP3100100.000ENSUMAG00000000428IGF2BP39996.032Ursus_maritimus
ENSG00000136231IGF2BP3100100.000ENSVPAG00000000613IGF2BP310099.231Vicugna_pacos
ENSG00000136231IGF2BP3100100.000ENSVVUG00000001063IGF2BP310098.618Vulpes_vulpes
ENSG00000136231IGF2BP39985.484ENSXETG00000007396igf2bp310081.940Xenopus_tropicalis
ENSG00000136231IGF2BP39787.179ENSXCOG00000000773igf2bp39767.776Xiphophorus_couchianus
ENSG00000136231IGF2BP39078.824ENSXCOG00000009912-9374.253Xiphophorus_couchianus
ENSG00000136231IGF2BP39667.949ENSXCOG00000009910-9968.354Xiphophorus_couchianus
ENSG00000136231IGF2BP39587.179ENSXMAG00000027959igf2bp310074.703Xiphophorus_maculatus
ENSG00000136231IGF2BP39874.561ENSXMAG00000003513igf2bp19673.484Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0003730mRNA 3'-UTR binding20080952.IDAFunction
GO:0005515protein binding17289661.IPIFunction
GO:0005634nucleus-IEAComponent
GO:0005737cytoplasm9891060.IDAComponent
GO:0005829cytosol-IDAComponent
GO:0005829cytosol-TASComponent
GO:0006412translation9891060.TASProcess
GO:0009653anatomical structure morphogenesis9891060.TASProcess
GO:0017148negative regulation of translation9891060.ISSProcess
GO:0042035regulation of cytokine biosynthetic process9891060.ICProcess
GO:0043488regulation of mRNA stability-TASProcess
GO:0045182translation regulator activity9891060.ISSFunction
GO:0048027mRNA 5'-UTR binding9891060.IDAFunction
GO:0051028mRNA transport-IEAProcess
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