EuRBPDB

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Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26721396	EGFR phosphorylates FAM129B to promote Ras activation.	Proc Natl Acad Sci U S A	2016 Jan 19	Ji H	doi: 10.1073/pnas.1517112113

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr9	127578944	5'UTR	novel		0.26
BLCA	chr9	127508134	In_Frame_Del	novel	S500del	0.15
BLCA	chr9	127507260	Missense_Mutation	NA	S609L	0.52
BLCA	chr9	127506782	3'UTR	novel		0.26
BLCA	chr9	127517911	Missense_Mutation	NA	P207R	0.53
BLCA	chr9	127517886	Missense_Mutation	NA	M215I	0.45
BRCA	chr9	127508523	Missense_Mutation	rs749442375	V445M	0.48
BRCA	chr9	127508175	Missense_Mutation	novel	V487E	0.33
BRCA	chr9	127523823	Missense_Mutation	NA	A149T	0.23
BRCA	chr9	127508154	Missense_Mutation	novel	E494G	0.07
BRCA	chr9	127527307	Missense_Mutation	rs769941762	R68C	0.41
CESC	chr9	127505495	3'UTR	novel		0.32
CESC	chr9	127517890	Missense_Mutation	novel	R214H	0.41
CESC	chr9	127507317	Missense_Mutation	novel	G590D	0.4
CESC	chr9	127508156	Silent	novel	R493R	0.33
CESC	chr9	127506631	3'UTR	novel		0.39
COAD	chr9	127517890	Missense_Mutation	novel	R214H	0.42
COAD	chr9	127527246	Missense_Mutation	rs549746967	R88H	0.39
COAD	chr9	127507029	Missense_Mutation	novel	A686V	0.38
COAD	chr9	127517010	Missense_Mutation	NA	A274T	0.27
COAD	chr9	127506676	3'UTR	novel		0.56
COAD	chr9	127508129	Silent	rs749991895	P502P	0.53
COAD	chr9	127527193	Splice_Site	novel	X105_splice	0.29
COAD	chr9	127523733	Missense_Mutation	NA	E179K	0.19
COAD	chr9	127531700	Missense_Mutation	rs773683224	R45H	0.33
COAD	chr9	127531761	Missense_Mutation	NA	L25M	0.24
COAD	chr9	127507899	Missense_Mutation	novel	V541A	0.1
COAD	chr9	127523840	Missense_Mutation	rs550046797	T143M	0.19
COAD	chr9	127525056	Splice_Site	novel	X141_splice	0.2
COAD	chr9	127507891	Missense_Mutation	novel	T544A	0.08
COAD	chr9	127516975	Silent	rs371948570	A285A	0.36
COAD	chr9	127517891	Missense_Mutation	rs756590981	R214C	0.16
ESCA	chr9	127507008	Missense_Mutation	rs368592407	P693L	0.17
ESCA	chr9	127506921	Missense_Mutation	novel	Q722L	0.5
ESCA	chr9	127527238	Missense_Mutation	novel	L91F	0.27
ESCA	chr9	127523819	Missense_Mutation	novel	P150L	0.55
GBM	chr9	127527250	Missense_Mutation	novel	N87D	0.32
GBM	chr9	127507368	Missense_Mutation	novel	N573T	0.18
GBM	chr9	127508189	Silent	rs144943149	Y482Y	0.18
GBM	chr9	127531729	Silent	novel	Q35Q	0.2
GBM	chr9	127509045	Silent	novel	G416G	0.21
GBM	chr9	127507174	Missense_Mutation	novel	S638C	0.46
GBM	chr9	127527301	Missense_Mutation	rs541599134	V70I	0.34
GBM	chr9	127510173	Silent	rs770588471	N378N	0.43
GBM	chr9	127510157	Nonsense_Mutation	novel	K384*	0.16
GBM	chr9	127508482	Silent	novel	K458K	0.3
HNSC	chr9	127507892	Missense_Mutation	novel	Q543H	0.13
HNSC	chr9	127510176	Silent	novel	I377I	0.41
HNSC	chr9	127508516	Missense_Mutation	rs780212910	T447M	0.2
HNSC	chr9	127516887	Missense_Mutation	novel	S315A	0.04
HNSC	chr9	127507260	Missense_Mutation	NA	S609L	0.1
KIRC	chr9	127525121	Missense_Mutation	NA	A120T	0.07
KIRC	chr9	127525134	Silent	rs370542607	A115A	0.77
LGG	chr9	127508173	Missense_Mutation	rs772145640	R488W	0.09
LGG	chr9	127523694	Missense_Mutation	rs773593282	R192W	0.18
LGG	chr9	127531700	Missense_Mutation	rs773683224	R45H	0.17
LIHC	chr9	127516981	Silent	NA	A283A	0.39
LIHC	chr9	127508978	Missense_Mutation	NA	E439K	0.11
LUAD	chr9	127506782	3'UTR	novel		0.74
LUAD	chr9	127523690	Missense_Mutation	NA	H193R	0.2
LUAD	chr9	127527296	Silent	novel	F71F	0.08
LUAD	chr9	127508469	Nonsense_Mutation	novel	E463*	0.1
LUSC	chr9	127507980	Splice_Site	novel	X515_splice	0.3
LUSC	chr9	127507307	Silent	rs755056956	Y593Y	0.09
LUSC	chr9	127516859	Missense_Mutation	NA	R324P	0.24
LUSC	chr9	127525130	Missense_Mutation	NA	I117V	0.24
LUSC	chr9	127507343	Silent	novel	L581L	0.41
LUSC	chr9	127527220	Missense_Mutation	rs370720142	G97W	0.4
LUSC	chr9	127531702	Missense_Mutation	NA	M44I	0.78
OV	chr9	127516958	Nonsense_Mutation	novel	*L291delinsHLLVTDFYHV**	0.1
OV	chr9	127509057	Silent	NA	L412L	0.3
OV	chr9	127531767	Missense_Mutation	novel	K23E	0.08
OV	chr9	127510208	Missense_Mutation	novel	K367Q	0.16
PAAD	chr9	127510251	Silent	novel	V352V	0.19
PAAD	chr9	127507100	Silent	novel	R662R	0.13
PAAD	chr9	127507101	Missense_Mutation	rs374739971	R662Q	0.13
PAAD	chr9	127507186	Missense_Mutation	novel	P634S	0.18
PAAD	chr9	127508110	Missense_Mutation	rs765640749	A509T	0.15
PAAD	chr9	127508150	Silent	rs570624473	A495A	0.13
PRAD	chr9	127523744	Missense_Mutation	NA	M175T	0.24
PRAD	chr9	127531653	Missense_Mutation	rs371821621	R61C	0.35
PRAD	chr9	127506920	Missense_Mutation	novel	Q722H	0.44
PRAD	chr9	127523736	Missense_Mutation	novel	A178S	0.24
SARC	chr9	127516955	Missense_Mutation	novel	S292C	0.23
SKCM	chr9	127516915	Silent	NA	I305I	0.61
SKCM	chr9	127517835	Missense_Mutation	NA	N232K	0.28
SKCM	chr9	127523794	Silent	NA	F158F	0.17
SKCM	chr9	127509006	Silent	NA	F429F	0.25
SKCM	chr9	127506918	Missense_Mutation	NA	V723E	0.37
SKCM	chr9	127508165	Silent	NA	R490R	0.55
SKCM	chr9	127507011	Missense_Mutation	NA	S692L	0.47
SKCM	chr9	127527235	Missense_Mutation	rs776632695	V92M	0.29
SKCM	chr9	127506833	3'UTR	novel		0.39
SKCM	chr9	127506981	Frame_Shift_Ins	novel	*L702Pfs44**	0.17
SKCM	chr9	127508158	Missense_Mutation	NA	R493W	0.45
SKCM	chr9	127507026	Missense_Mutation	NA	A687G	0.82
SKCM	chr9	127516861	Silent	NA	I323I	0.25
SKCM	chr9	127525066	Missense_Mutation	NA	S138F	0.28
SKCM	chr9	127578967	5'UTR	novel		0.21
SKCM	chr9	127516961	Missense_Mutation	NA	V290G	0.55
SKCM	chr9	127525107	Silent	NA	I124I	0.17
SKCM	chr9	127508130	Missense_Mutation	rs762335780	P502L	0.33
SKCM	chr9	127507927	Silent	novel	L532L	0.27
STAD	chr9	127508998	Missense_Mutation	rs760512238	R432Q	0.16
STAD	chr9	127517911	Missense_Mutation	NA	P207H	0.17
STAD	chr9	127509095	Frame_Shift_Del	novel	L400*	0.39
STAD	chr9	127507969	Missense_Mutation	rs780940200	R518W	0.48
STAD	chr9	127516859	Missense_Mutation	rs778880991	R324Q	0.36
STAD	chr9	127523804	Missense_Mutation	novel	P155H	0.19
STAD	chr9	127506808	3'UTR	rs761835399		0.33
STAD	chr9	127506870	Missense_Mutation	NA	S739N	0.06
STAD	chr9	127527195	Missense_Mutation	rs527792182	A105V	0.5
STAD	chr9	127516990	Silent	novel	Y280Y	0.38
STAD	chr9	127527301	Missense_Mutation	rs541599134	V70I	0.17
STAD	chr9	127531769	Missense_Mutation	NA	G22E	0.15
STAD	chr9	127510167	Silent	rs372647854	G380G	0.23
STAD	chr9	127531700	Missense_Mutation	rs773683224	R45H	0.31
STAD	chr9	127509062	Missense_Mutation	NA	S411P	0.23
STAD	chr9	127507055	Silent	novel	P677P	0.3
STAD	chr9	127510286	Missense_Mutation	NA	P341S	0.27
STAD	chr9	127517124	Silent	NA	R266R	0.1
STAD	chr9	127509035	Nonsense_Mutation	NA	R420*	0.39
THCA	chr9	127516886	Missense_Mutation	NA	S315F	0.21
THCA	chr9	127508519	Missense_Mutation	NA	Y446C	0.06
UCEC	chr9	127525098	Silent	rs766348775	S127S	0.04
UCEC	chr9	127506561	3'UTR	novel		0.28
UCEC	chr9	127510181	Missense_Mutation	rs745730530	V376I	0.07
UCEC	chr9	127525138	Missense_Mutation	rs750582287	R114Q	0.43
UCEC	chr9	127508194	Missense_Mutation	NA	D481N	0.24
UCEC	chr9	127527235	Missense_Mutation	rs776632695	V92M	0.33
UCEC	chr9	127525123	Missense_Mutation	rs575722854	S119N	0.65
UCEC	chr9	127509105	Silent	rs546349539	A396A	0.29
UCEC	chr9	127523791	Silent	rs528460174	P159P	0.32
UCEC	chr9	127517157	Silent	rs200164544	P255P	0.52
UCEC	chr9	127508151	Missense_Mutation	NA	A495V	0.13
UCEC	chr9	127531660	Silent	novel	L58L	0.18
UCEC	chr9	127506919	Missense_Mutation	novel	V723M	0.33
UCEC	chr9	127506807	3'UTR	rs774322928		0.32
UCEC	chr9	127507356	Missense_Mutation	novel	N577S	0.33
UCEC	chr9	127523768	Missense_Mutation	rs559492611	A167V	0.38
UCEC	chr9	127507889	Silent	rs775455466	T544T	0.45
UCEC	chr9	127507909	Missense_Mutation	novel	E538K	0.63
UCEC	chr9	127531706	Missense_Mutation	NA	S43N	0.39
UCEC	chr9	127507296	Missense_Mutation	novel	G597D	0.5
UCEC	chr9	127505459	3'UTR	novel		0.42
UCEC	chr9	127505567	3'UTR	novel		0.63
UCEC	chr9	127508512	Silent	rs756098208	F448F	0.49
UCEC	chr9	127509015	Silent	rs753880584	T426T	0.42
UCEC	chr9	127508446	Silent	novel	Q470Q	0.38
UCEC	chr9	127517008	Silent	rs148413718	A274A	0.32
UCEC	chr9	127517825	Splice_Site	novel	X235_splice	0.48
UCEC	chr9	127516973	Missense_Mutation	rs749689723	R286H	0.38
UCEC	chr9	127509035	Nonsense_Mutation	NA	R420*	0.24
UCEC	chr9	127505459	3'UTR	novel		0.41
UCEC	chr9	127506768	3'UTR	novel		0.4
UCEC	chr9	127531700	Missense_Mutation	rs773683224	R45H	0.37
UCEC	chr9	127508523	Missense_Mutation	rs749442375	V445M	0.37
UCEC	chr9	127510334	Splice_Site	novel	X325_splice	0.41
UCEC	chr9	127510186	Missense_Mutation	novel	L374P	0.34

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CHOL	DEL	0.4167	0.067545
LAML	DEL	0.0052	0.24147
LGG	AMP	0.0624	0.21332
LIHC	DEL	0.2514	0.12467
PRAD	AMP	0.0833	0.059049
THCA	DEL	0.0401	0.24038
THYM	DEL	0.0163	0.022012
UCS	DEL	0.5357	0.089783

Survival Analysis

Cancer	P-value	Q-value
STAD	0.0084	Kaplan-Meier Survival Analysis
MESO	0.00017	Kaplan-Meier Survival Analysis
UCS	0.04	Kaplan-Meier Survival Analysis
SKCM	0.0044	Kaplan-Meier Survival Analysis
LUSC	0.0047	Kaplan-Meier Survival Analysis
BRCA	0.015	Kaplan-Meier Survival Analysis
COAD	0.032	Kaplan-Meier Survival Analysis
PAAD	0.00077	Kaplan-Meier Survival Analysis
BLCA	0.004	Kaplan-Meier Survival Analysis
LAML	0.0084	Kaplan-Meier Survival Analysis
KICH	0.037	Kaplan-Meier Survival Analysis
GBM	0.016	Kaplan-Meier Survival Analysis
LIHC	0.05	Kaplan-Meier Survival Analysis
LGG	0.012	Kaplan-Meier Survival Analysis
LUAD	0.0087	Kaplan-Meier Survival Analysis
UVM	0.021	Kaplan-Meier Survival Analysis
OV	0.0066	Kaplan-Meier Survival Analysis

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000136830 (Gene tree)
Gene ID: 64855
Gene Symbol: FAM129B
Alias: DKFZP434H0820|FLJ13518|FLJ22151|FLJ22298|bA356B19.6|MINERVA|C9orf88
Full Name: family with sequence similarity 129 member B
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 73,670 bases
Position: chr9:127,505,338-127,579,007
Accession: 25282
RBP type: non-canonical RBP
Summary: (Family With Sequence Similarity 129 Member B) is a Protein Coding gene. Among its related pathways are MAP Kinase Signaling. An important paralog of this gene is FAM129A.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
27770549	Long noncoding RNA MEG3 induces cholestatic liver injury by interaction with PTBP1 to facilitate shp mRNA decay.	Hepatology	2017 Feb	Zhang L	doi: 10.1002/hep.28882

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000465154	FAM129B-203	483	-	-	- (aa)	-	-
ENST00000373312	FAM129B-201	3957	XM_011518925	ENSP00000362409	746 (aa)	XP_011517227	Q96TA1
ENST00000373314	FAM129B-202	3760	XM_005252135	ENSP00000362411	733 (aa)	XP_005252192	Q96TA1
ENST00000478917	FAM129B-206	362	-	-	- (aa)	-	-
ENST00000484348	FAM129B-207	654	-	-	- (aa)	-	-
ENST00000468379	FAM129B-204	828	-	-	- (aa)	-	-
ENST00000476091	FAM129B-205	386	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000136830's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000136830	Blood Pressure	4.2913770E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000136830	rs72767980	9	127558278	C	Heel bone mineral density	28869591	[0.023-0.041] unit decrease	0.0319678	EFO_0009270
ENSG00000136830	rs72767980	9	127558278	C	Heel bone mineral density	28869591	[0.028-0.054] unit decrease	0.0411468	EFO_0009270
ENSG00000136830	rs72767980	9	127558278	?	Heel bone mineral density	30048462	[0.023-0.034] unit decrease	0.0286656	EFO_0009270
ENSG00000136830	rs2491105	9	127558004	T	Heel bone mineral density	30598549	[0.019-0.027] unit decrease	0.0231404	EFO_0009270
ENSG00000136830	rs1891730	9	127546749	T	Systolic blood pressure	30224653	[0.13-0.23] mmHg decrease	0.1785	EFO_0006335
ENSG00000136830	rs2243558	9	127527336	?	Mean corpuscular hemoglobin	30595370			EFO_0004527
ENSG00000136830	rs2244843	9	127509387	?	White blood cell count	30595370			EFO_0004308
ENSG00000136830	rs72767980	9	127558278	?	Heel bone mineral density	30595370			EFO_0009270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000136830's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003713	transcription coactivator activity	17569660.	IDA	Function
GO:0005634	nucleus	14602737.	IDA	Component
GO:0005634	nucleus	21148485.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	14602737.18628527.	IDA	Component
GO:0005829	cytosol	21148485.	IDA	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0005912	adherens junction	21148485.	IDA	Component
GO:0007411	axon guidance	-	ISS	Process
GO:0008285	negative regulation of cell proliferation	14602737.17569660.20032057.20179190.	IDA	Process
GO:0016525	negative regulation of angiogenesis	-	ISS	Process
GO:0030154	cell differentiation	-	ISS	Process
GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway	-	ISS	Process
GO:0032274	gonadotropin secretion	14602737.	IEP	Process
GO:0032274	gonadotropin secretion	18628527.	IMP	Process
GO:0040019	positive regulation of embryonic development	-	ISS	Process
GO:0043066	negative regulation of apoptotic process	21148485.	IMP	Process
GO:0044029	hypomethylation of CpG island	-	ISS	Process
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0045746	negative regulation of Notch signaling pathway	-	ISS	Process
GO:0045892	negative regulation of transcription, DNA-templated	17569660.	IDA	Process
GO:0045893	positive regulation of transcription, DNA-templated	17569660.20032057.20179190.	IDA	Process
GO:0048743	positive regulation of skeletal muscle fiber development	-	ISS	Process
GO:0070062	extracellular exosome	19056867.23533145.	HDA	Component
GO:2000279	negative regulation of DNA biosynthetic process	14602737.17569660.20032057.	IDA	Process
GO:2000679	positive regulation of transcription regulatory region DNA binding	17569660.	IDA	Process

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.