EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr9	127665278	Missense_Mutation	novel	L204I	0.17
BLCA	chr9	127675840	Missense_Mutation	NA	I383F	0.23
BLCA	chr9	127669937	Missense_Mutation	novel	K314N	0.06
BLCA	chr9	127663322	Silent	rs753725349	L183L	0.71
BLCA	chr9	127658431	Missense_Mutation	novel	L76V	0.39
BLCA	chr9	127660075	Frame_Shift_Del	novel	*K98Nfs22**	0.21
BLCA	chr9	127663335	Missense_Mutation	novel	P187Q	0.13
BLCA	chr9	127660033	Missense_Mutation	rs34830702	V84I	0.3
BLCA	chr9	127672093	Nonsense_Mutation	NA	Q336*	0.2
BLCA	chr9	127658431	Missense_Mutation	novel	L76V	0.17
BRCA	chr9	127678511	Silent	rs770793946	P480P	0.32
BRCA	chr9	127663342	Splice_Site	novel	X190_splice	0.18
BRCA	chr9	127668106	Missense_Mutation	NA	A274V	0.28
BRCA	chr9	127661182	Missense_Mutation	NA	A136T	0.17
BRCA	chr9	127665273	Missense_Mutation	NA	A202D	0.16
BRCA	chr9	127692374	3'UTR	rs184910296		0.35
CESC	chr9	127663429	Intron	novel		0.5
CESC	chr9	127663430	Intron	NA		0.5
CESC	chr9	127676641	Splice_Region	novel		0.52
CESC	chr9	127653730	Nonsense_Mutation	NA	Q35*	0.26
CESC	chr9	127666261	Frame_Shift_Del	novel	*Y254Mfs23**	0.29
CESC	chr9	127665311	Missense_Mutation	NA	D215N	0.23
CESC	chr9	127660061	Missense_Mutation	novel	D93G	0.35
CESC	chr9	127663270	Missense_Mutation	novel	K165N	0.41
CESC	chr9	127692414	3'UTR	novel		0.34
CESC	chr9	127666206	Missense_Mutation	rs794727970	R235Q	0.19
CESC	chr9	127695097	3'Flank	NA		0.34
COAD	chr9	127678446	Missense_Mutation	rs750968891	R459W	0.38
COAD	chr9	127691034	3'UTR	novel		0.24
COAD	chr9	127678446	Missense_Mutation	rs750968891	R459W	0.46
COAD	chr9	127675913	Missense_Mutation	NA	I407T	0.27
COAD	chr9	127668174	Missense_Mutation	NA	A297T	0.26
COAD	chr9	127690852	Missense_Mutation	novel	S594G	0.05
COAD	chr9	127668098	Silent	NA	I271I	0.33
COAD	chr9	127658448	Missense_Mutation	novel	E81D	0.1
COAD	chr9	127669920	Missense_Mutation	NA	D309Y	0.18
COAD	chr9	127682509	Missense_Mutation	rs796053373	R551C	0.2
COAD	chr9	127663304	Missense_Mutation	NA	A177T	0.26
COAD	chr9	127690869	3'UTR	rs562655664		0.51
ESCA	chr9	127692511	3'UTR	novel		0.17
ESCA	chr9	127682424	Nonsense_Mutation	novel	W522*	0.5
GBM	chr9	127666281	Missense_Mutation	novel	E260A	0.06
HNSC	chr9	127665258	Missense_Mutation	novel	D197V	0.3
HNSC	chr9	127651640	Missense_Mutation	novel	K25N	0.22
HNSC	chr9	127684368	Intron	novel		0.21
KIRC	chr9	127651619	Silent	NA	V18V	0.4
KIRP	chr9	127675858	Missense_Mutation	NA	A389T	0.24
LGG	chr9	127690883	3'UTR	rs575012484		0.1
LGG	chr9	127682452	Missense_Mutation	novel	R532C	0.43
LGG	chr9	127612380	5'UTR	novel		0.36
LIHC	chr9	127612321	5'UTR	novel		0.41
LIHC	chr9	127661101	Splice_Site	novel	X109_splice	0.11
LIHC	chr9	127658426	Missense_Mutation	novel	V74A	0.24
LIHC	chr9	127672061	Missense_Mutation	novel	R325Q	0.49
LIHC	chr9	127666234	Silent	NA	L244L	0.3
LIHC	chr9	127680206	Missense_Mutation	NA	T504I	0.78
LUAD	chr9	127658419	Missense_Mutation	novel	E72Q	0.09
LUAD	chr9	127675921	Missense_Mutation	novel	L410F	0.19
LUAD	chr9	127658440	Missense_Mutation	NA	P79A	0.11
LUAD	chr9	127658433	Silent	novel	L76L	0.08
LUAD	chr9	127668097	Missense_Mutation	NA	I271T	0.24
LUAD	chr9	127666214	Missense_Mutation	NA	D238H	0.6
LUAD	chr9	127690909	3'UTR	novel		0.1
LUAD	chr9	127669932	Missense_Mutation	NA	S313C	0.2
LUSC	chr9	127668110	Silent	NA	R275R	0.11
LUSC	chr9	127651613	Missense_Mutation	novel	H16Q	0.56
LUSC	chr9	127668122	Silent	novel	V279V	0.26
OV	chr9	127661166	Silent	NA	L130L	0.17
OV	chr9	127690850	Missense_Mutation	NA	S593N	0.37
OV	chr9	127691200	3'UTR	novel		0.5
PAAD	chr9	127663335	Missense_Mutation	novel	P187L	0.19
PAAD	chr9	127668108	Missense_Mutation	rs780641675	R275W	0.14
PAAD	chr9	127680194	Missense_Mutation	novel	P500R	0.08
PRAD	chr9	127675811	Missense_Mutation	novel	A373V	0.42
PRAD	chr9	127675899	Silent	rs780284511	Y402Y	0.09
READ	chr9	127684486	Intron	novel		0.16
READ	chr9	127690940	3'UTR	novel		0.19
SARC	chr9	127676745	Missense_Mutation	rs150259704	V451I	0.31
SARC	chr9	127675842	Silent	novel	I383I	0.21
SARC	chr9	127675873	Silent	novel	L394L	0.21
SARC	chr9	127675929	Missense_Mutation	novel	I412M	0.21
SKCM	chr9	127666225	Silent	novel	S241S	0.34
SKCM	chr9	127666198	Silent	novel	I232I	0.5
SKCM	chr9	127663212	Missense_Mutation	novel	S146F	0.48
SKCM	chr9	127663349	Missense_Mutation	NA	R192W	0.16
SKCM	chr9	127660080	Silent	rs149736085	Y99Y	0.85
SKCM	chr9	127661114	Missense_Mutation	NA	A113V	0.29
SKCM	chr9	127682478	Silent	NA	F540F	0.19
SKCM	chr9	127672070	Missense_Mutation	novel	S328F	0.3
STAD	chr9	127675816	Missense_Mutation	novel	G375S	0.28
STAD	chr9	127676736	Missense_Mutation	NA	V448M	0.22
STAD	chr9	127680234	Silent	rs751251068	T513T	0.2
STAD	chr9	127690869	3'UTR	rs562655664		0.29
STAD	chr9	127612343	5'UTR	novel		0.44
STAD	chr9	127675929	Frame_Shift_Ins	novel	*L414Ffs24**	0.24
STAD	chr9	127660090	Missense_Mutation	novel	H103Y	0.37
STAD	chr9	127690856	Frame_Shift_Del	rs752807764		0.2
STAD	chr9	127660040	Missense_Mutation	novel	S86C	0.13
STAD	chr9	127676650	Missense_Mutation	rs748965227	T419M	0.33
STAD	chr9	127653759	Silent	rs373660650	C44C	0.31
STAD	chr9	127653759	Silent	rs373660650	C44C	0.21
STAD	chr9	127653794	Missense_Mutation	NA	T56M	0.49
STAD	chr9	127668174	Missense_Mutation	NA	A297T	0.23
UCEC	chr9	127669920	Missense_Mutation	NA	D309Y	0.28
UCEC	chr9	127691069	3'UTR	novel		0.21
UCEC	chr9	127695022	3'Flank	novel		0.07
UCEC	chr9	127690800	Missense_Mutation	NA	Q576H	0.3
UCEC	chr9	127680235	Missense_Mutation	novel	A514T	0.38
UCEC	chr9	127682445	Silent	rs573931063	G529G	0.34
UCEC	chr9	127668093	Missense_Mutation	rs146566779	G270S	0.14
UCEC	chr9	127692389	3'UTR	novel		0.44
UCEC	chr9	127680224	Missense_Mutation	NA	F510C	0.44
UCEC	chr9	127692030	3'UTR	novel		0.53
UCEC	chr9	127691057	3'UTR	novel		0.39
UCEC	chr9	127682411	Missense_Mutation	novel	R518H	0.44
UCEC	chr9	127692320	3'UTR	novel		0.46
UCEC	chr9	127612426	Missense_Mutation	novel	A8V	0.45
UCEC	chr9	127661141	Missense_Mutation	rs773885228	R122Q	0.52
UCEC	chr9	127672060	Missense_Mutation	novel	R325W	0.42
UCEC	chr9	127682509	Missense_Mutation	rs796053373	R551C	0.4
UCEC	chr9	127692170	3'UTR	novel		0.25
UCEC	chr9	127673258	Missense_Mutation	NA	E369D	0.25
UCEC	chr9	127675864	Missense_Mutation	rs751520067	V391I	0.47
UCEC	chr9	127682560	Missense_Mutation	novel	G568R	0.38
UCEC	chr9	127653795	Splice_Region	NA	T56T	0.18
UCEC	chr9	127675864	Missense_Mutation	rs751520067	V391I	0.23
UCEC	chr9	127665272	Missense_Mutation	NA	A202T	0.17
UCEC	chr9	127676732	Silent	rs752950410	L446L	0.21
UCEC	chr9	127658395	Missense_Mutation	rs760033783	R64C	0.4
UCEC	chr9	127666165	Splice_Site	NA	X222_splice	0.29
UCEC	chr9	127651614	Missense_Mutation	novel	D17Y	0.54
UCEC	chr9	127675876	Missense_Mutation	novel	L395M	0.4
UCEC	chr9	127692535	3'UTR	novel		0.47
UCEC	chr9	127663305	Missense_Mutation	novel	A177V	0.31
UCEC	chr9	127693254	3'Flank	novel		0.31
UCEC	chr9	127668098	Silent	NA	I271I	0.33
UCEC	chr9	127663210	Nonsense_Mutation	NA	Y145*	0.26
UCEC	chr9	127663271	Missense_Mutation	novel	N166H	0.49
UCEC	chr9	127676719	Missense_Mutation	novel	N442S	0.33
UCEC	chr9	127678457	Silent	rs201146381	P462P	0.42
UCEC	chr9	127669937	Missense_Mutation	novel	K314N	0.5
UCEC	chr9	127663349	Missense_Mutation	NA	R192W	0.34
UCEC	chr9	127682510	Missense_Mutation	NA	R551H	0.2
UCEC	chr9	127692511	3'UTR	novel		0.1
UCEC	chr9	127684410	Intron	novel		0.67
UCEC	chr9	127668138	Missense_Mutation	NA	D285Y	0.28
UCEC	chr9	127692695	3'UTR	novel		0.26
UCEC	chr9	127676697	Missense_Mutation	NA	E435K	0.06
UCEC	chr9	127690821	Missense_Mutation	novel	K583N	0.05
UCEC	chr9	127658397	Silent	novel	R64R	0.64
UCEC	chr9	127676735	Silent	rs367980635	G447G	0.42
UCEC	chr9	127661183	Missense_Mutation	novel	A136V	0.16
UCEC	chr9	127668132	Missense_Mutation	rs587777310	E283K	0.19
UCEC	chr9	127668134	Silent	novel	E283E	0.18
UCEC	chr9	127684415	Intron	novel		0.15
UCEC	chr9	127675913	Missense_Mutation	novel	I407S	0.32
UCEC	chr9	127668174	Missense_Mutation	NA	A297T	0.31
UCEC	chr9	127680170	Missense_Mutation	novel	D492G	0.07

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CHOL	DEL	0.4167	0.067545
LAML	DEL	0.0052	0.24147
LGG	AMP	0.0624	0.21332
LIHC	DEL	0.2486	0.12467
PRAD	AMP	0.0833	0.059049
THCA	DEL	0.0401	0.24038
THYM	DEL	0.0163	0.022012
UCS	DEL	0.5536	0.089783

Survival Analysis

Cancer	P-value	Q-value
THYM	0.039	Kaplan-Meier Survival Analysis
KIRC	0.00015	Kaplan-Meier Survival Analysis
ACC	0.0036	Kaplan-Meier Survival Analysis
UCS	0.0019	Kaplan-Meier Survival Analysis
HNSC	0.00022	Kaplan-Meier Survival Analysis
PRAD	0.019	Kaplan-Meier Survival Analysis
LUSC	0.0012	Kaplan-Meier Survival Analysis
BRCA	0.014	Kaplan-Meier Survival Analysis
PAAD	0.00064	Kaplan-Meier Survival Analysis
BLCA	0.00032	Kaplan-Meier Survival Analysis
READ	0.0093	Kaplan-Meier Survival Analysis
UCEC	0.00041	Kaplan-Meier Survival Analysis
LIHC	0.0013	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
CHOL	0.03	Kaplan-Meier Survival Analysis
LUAD	0.00044	Kaplan-Meier Survival Analysis
OV	0.0068	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000136854 (Gene tree)
Gene ID: 6812
Gene Symbol: STXBP1
Alias: hUNC18|MUNC18-1|UNC18|rbSec1
Full Name: syntaxin binding protein 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 116,658 bases
Position: chr9:127,579,370-127,696,027
Accession: 11444
RBP type: non-canonical RBP
Summary: This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000627871	STXBP1-210	538	-	ENSP00000485895	100 (aa)	-	A0A0D9SEP9
ENST00000373299	STXBP1-201	3765	-	ENSP00000362396	594 (aa)	-	P61764
ENST00000636962	STXBP1-216	2918	-	ENSP00000489762	574 (aa)	-	A0A1B0GWF2
ENST00000637173	STXBP1-218	4193	-	ENSP00000490519	580 (aa)	-	A0A0D9SG72
ENST00000496504	STXBP1-205	591	-	ENSP00000485361	75 (aa)	-	A0A096LP33
ENST00000626539	STXBP1-209	3840	-	ENSP00000487211	580 (aa)	-	A0A0D9SG72
ENST00000637521	STXBP1-220	2068	-	ENSP00000489791	589 (aa)	-	A0A1B0GTP9
ENST00000637464	STXBP1-219	4893	-	ENSP00000489655	55 (aa)	-	A0A1B0GTD8
ENST00000494254	STXBP1-204	563	-	ENSP00000485397	119 (aa)	-	A0A096LP52
ENST00000635950	STXBP1-214	2771	-	ENSP00000490903	574 (aa)	-	A0A1B0GWF2
ENST00000626333	STXBP1-207	667	-	ENSP00000486814	147 (aa)	-	A0A0D9SFQ7
ENST00000647107	STXBP1-222	1843	-	ENSP00000494727	580 (aa)	-	A0A2R8Y5D4
ENST00000626416	STXBP1-208	3700	-	-	- (aa)	-	-
ENST00000637060	STXBP1-217	3825	-	ENSP00000490674	112 (aa)	-	A0A1B0GVV9
ENST00000625363	STXBP1-206	550	-	ENSP00000486944	149 (aa)	-	A0A0D9SFW6
ENST00000636509	STXBP1-215	3894	-	ENSP00000490810	360 (aa)	-	A0A1B0GW76
ENST00000628638	STXBP1-211	581	-	-	- (aa)	-	-
ENST00000373302	STXBP1-202	3967	-	ENSP00000362399	603 (aa)	-	P61764
ENST00000628768	STXBP1-212	2582	-	-	- (aa)	-	-
ENST00000630492	STXBP1-213	572	-	ENSP00000485680	102 (aa)	-	A0A0D9SEH5
ENST00000476182	STXBP1-203	566	-	ENSP00000490199	22 (aa)	-	A0A1B0GUQ2
ENST00000637953	STXBP1-221	3925	-	ENSP00000490613	577 (aa)	-	A0A1B0GVQ5

Gene Model

Click here to download ENSG00000136854's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04721	Synaptic vesicle cycle	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000136854	rs10819303	9	127630675	A	Educational attainment (MTAG)	30038396	[0.0056-0.0106] unit decrease	0.0081	EFO_0004784
ENSG00000136854	rs10819303	9	127630675	A	Highest math class taken (MTAG)	30038396	[0.0063-0.0129] unit decrease	0.0096	EFO_0004875
ENSG00000136854	rs2039204	9	127608828	A	Educational attainment (years of education)	30038396	[0.0055-0.0109] unit increase	0.0082	EFO_0004784
ENSG00000136854	rs1573178	9	127610208	T	Educational attainment (years of education)	30038396	[0.006-0.0114] unit decrease	0.0087	EFO_0004784

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000136854's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000149	SNARE binding	-	ISS	Function
GO:0002576	platelet degranulation	12773094.	IMP	Process
GO:0003006	developmental process involved in reproduction	-	IEA	Process
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005515	protein binding	25416956.25910212.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	-	ISS	Component
GO:0005739	mitochondrion	-	ISS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005856	cytoskeleton	-	IEA	Component
GO:0005886	plasma membrane	12773094.	IDA	Component
GO:0005886	plasma membrane	-	ISS	Component
GO:0006904	vesicle docking involved in exocytosis	-	ISS	Process
GO:0007269	neurotransmitter secretion	-	TAS	Process
GO:0007274	neuromuscular synaptic transmission	-	IEA	Process
GO:0007412	axon target recognition	-	ISS	Process
GO:0010807	regulation of synaptic vesicle priming	-	ISS	Process
GO:0014047	glutamate secretion	-	TAS	Process
GO:0015031	protein transport	-	IEA	Process
GO:0016082	synaptic vesicle priming	-	IEA	Process
GO:0016188	synaptic vesicle maturation	-	ISS	Process
GO:0017075	syntaxin-1 binding	12730201.19748891.	IPI	Function
GO:0017075	syntaxin-1 binding	-	ISS	Function
GO:0019901	protein kinase binding	-	IEA	Function
GO:0019904	protein domain specific binding	-	IEA	Function
GO:0019905	syntaxin binding	12773094.	IPI	Function
GO:0030424	axon	-	IEA	Component
GO:0031091	platelet alpha granule	12773094.	IDA	Component
GO:0031333	negative regulation of protein complex assembly	-	IEA	Process
GO:0031630	regulation of synaptic vesicle fusion to presynaptic active zone membrane	15217342.	TAS	Process
GO:0032229	negative regulation of synaptic transmission, GABAergic	-	ISS	Process
GO:0032355	response to estradiol	-	IEA	Process
GO:0032991	protein-containing complex	-	ISS	Component
GO:0035542	regulation of SNARE complex assembly	15217342.	TAS	Process
GO:0042802	identical protein binding	-	ISS	Function
GO:0043274	phospholipase binding	-	IEA	Function
GO:0043306	positive regulation of mast cell degranulation	-	IEA	Process
GO:0043524	negative regulation of neuron apoptotic process	-	IEA	Process
GO:0045335	phagocytic vesicle	-	IEA	Component
GO:0045956	positive regulation of calcium ion-dependent exocytosis	-	IEA	Process
GO:0047485	protein N-terminus binding	-	IEA	Function
GO:0048471	perinuclear region of cytoplasm	-	IEA	Component
GO:0048787	presynaptic active zone membrane	-	IEA	Component
GO:0050821	protein stabilization	-	IEA	Process
GO:0060292	long-term synaptic depression	-	IEA	Process
GO:0070062	extracellular exosome	19056867.	HDA	Component
GO:0070527	platelet aggregation	12773094.	IMP	Process
GO:0071346	cellular response to interferon-gamma	-	IEA	Process
GO:0072659	protein localization to plasma membrane	17543282.	IDA	Process
GO:0098794	postsynapse	-	IEA	Component
GO:0098978	glutamatergic synapse	-	IEA	Component
GO:0099525	presynaptic dense core vesicle exocytosis	-	IEA	Process
GO:0106022	positive regulation of vesicle docking	-	IEA	Process
GO:1903296	positive regulation of glutamate secretion, neurotransmission	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.