EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26071407	Tumor-induced inflammation in mammary adipose tissue stimulates a vicious cycle of autotaxin expression and breast cancer progression.	FASEB J	2015 Sep	Benesch MG	doi: 10.1096/fj.15-274480
25277122	Interaction of platelet-derived autotaxin with tumor integrin αVβ3 controls metastasis of breast cancer cells to bone.	Blood	2014 Nov 13	Leblanc R	doi: 10.1182/blood-2014-04-568683
18337445	Positive feedback between vascular endothelial growth factor-A and autotaxin in ovarian cancer cells.	Mol Cancer Res	2008 Mar	Ptaszynska MM	doi: 10.1158/1541-7786.MCR-07-0143.
17013094	Autotaxin stimulates urokinase-type plasminogen activator expression through phosphoinositide 3-kinase-Akt-nuclear [corrected] factor kappa B signaling cascade in human melanoma cells.	Melanoma Res	2006 Oct	Lee J	-
18249559	Scalable purification and characterization of the extracellular domain of human autotaxin from prokaryotic cells.	Protein Expr Purif	2008 May	Haga A	doi: 10.1016/j.pep.2007.12.008
30396320	Promotion of cell-invasive activity through the induction of LPA receptor-1 in pancreatic cancer cells.	J Recept Signal Transduct Res	2018 Aug	Fukushima K	doi: 10.1080/10799893.2018.1531889
16627485	Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine to lysophosphatidic acid.	J Biol Chem	2006 Jun 23	Kishi Y	-
22700442	Serum autotaxin is not a useful biomarker for ovarian cancer.	Lipids	2012 Sep	Nakamura K	doi: 10.1007/s11745-012-3691-0
21439952	Specific increase in serum autotaxin activity in patients with pancreatic cancer.	Clin Biochem	2011 Jun	Nakai Y	doi: 10.1016/j.clinbiochem.2011.03.128
28347252	The critical role and potential target of the autotaxin/lysophosphatidate axis in pancreatic cancer.	Tumour Biol	2017 Mar	Quan M	doi: 10.1177/1010428317694544.
19477432	Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases.	Cancer Cell	2009 Jun 2	Liu S	doi: 10.1016/j.ccr.2009.03.027.
19506801	Autotaxin.	Cell Mol Life Sci	2009 Sep	Boutin JA	doi: 10.1007/s00018-009-0056-9
12498389	Expression of autotaxin (NPP-2) is closely linked to invasiveness of breast cancer cells.	Clin Exp Metastasis	2002	Yang SY	-
26391552	Understanding the Multifaceted Role of Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) and its Altered Behaviour in Human Diseases.	Curr Mol Med	2015	Cholia RP	-
20888793	Autotaxin: a protein with two faces.	Biochem Biophys Res Commun	2010 Oct 29	Tania M	doi: 10.1016/j.bbrc.2010.09.114
19549252	Expression of autotaxin and acylglycerol kinase in prostate cancer: association with cancer development and progression.	Cancer Sci	2009 Sep	Nouh MA	doi: 10.1111/j.1349-7006.2009.01234.x
25195735	The role and therapeutic potential of the autotaxin-lysophosphatidate signalling axis in breast cancer.	Biochem J	2014 Oct 1	Teo K	doi: 10.1042/BJ20140680.
16356477	The candidate tumor suppressor CST6 alters the gene expression profile of human breast carcinoma cells: down-regulation of the potent mitogenic, motogenic, and angiogenic factor autotaxin.	Biochem Biophys Res Commun	2006 Feb 3	Song J	-
26037280	Autotaxin is an inflammatory mediator and therapeutic target in thyroid cancer.	Endocr Relat Cancer	2015 Aug	Benesch MG	doi: 10.1530/ERC-15-0045
21765444	Cholera toxin inhibits human hepatocarcinoma cell proliferation in vitro via suppressing ATX/LPA axis.	Acta Pharmacol Sin	2011 Aug	Xia Q	doi: 10.1038/aps.2011.31
25896349	Regulation of autotaxin expression and secretion by lysophosphatidate and sphingosine 1-phosphate.	J Lipid Res	2015 Jun	Benesch MG	doi: 10.1194/jlr.M057661
26800320	Autotaxin Regulates Maintenance of Ovarian Cancer Stem Cells through Lysophosphatidic Acid-Mediated Autocrine Mechanism.	Stem Cells	2016 Mar	Seo EJ	doi: 10.1002/stem.2279
22140473	Stat3 mediates expression of autotaxin in breast cancer.	PLoS One	2011	Azare J	doi: 10.1371/journal.pone.0027851
20623382	Immunohistochemical detection of autotaxin (ATX)/lysophospholipase D (lysoPLD) in submucosal invasive colorectal cancer.	J Gastrointest Cancer	2011 Dec	Kazama S	doi: 10.1007/s12029-010-9186-4.
23258351	Short hairpin RNA targeting autotaxin reduces human gastric carcinoma AGS cell proliferative, migratory and invasive capabilities in vitro and causes tumor regression in vivo.	Oncol Rep	2013 Mar	Chen Z	doi: 10.3892/or.2012.2204
27784781	Autotaxin Expression Is Regulated at the Post-transcriptional Level by the RNA-binding Proteins HuR and AUF1.	J Biol Chem	2016 Dec 9	Sun S	-
29328374	ATXLPA axis facilitates estrogeninduced endometrial cancer cell proliferation via MAPK/ERK signaling pathway.	Mol Med Rep	2018 Mar	Zhang G	doi: 10.3892/mmr.2018.8392
30374843	Autotaxin is a novel molecular identifier of type I endometrial cancer.	Med Oncol	2018 Oct 29	Mazzocca A	doi: 10.1007/s12032-018-1222-4.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr8	119582582	Missense_Mutation	novel	A522P	0.27
ACC	chr8	119569327	Missense_Mutation	rs753919036	R654Q	0.07
BLCA	chr8	119638463	Missense_Mutation	novel	I33N	0.22
BLCA	chr8	119616350	Missense_Mutation	novel	N231I	0.15
BLCA	chr8	119586229	Missense_Mutation	NA	E442Q	0.29
BLCA	chr8	119607928	Missense_Mutation	novel	W276L	0.16
BLCA	chr8	119562854	Splice_Region	novel		0.29
BLCA	chr8	119626634	Missense_Mutation	novel	R75G	0.07
BLCA	chr8	119570744	Missense_Mutation	novel	F626L	0.21
BLCA	chr8	119619297	Silent	rs200364301	S142S	0.29
BLCA	chr8	119619287	Missense_Mutation	novel	D146H	0.27
BLCA	chr8	119616323	Frame_Shift_Ins	novel	*A240Vfs37**	0.05
BLCA	chr8	119616325	Frame_Shift_Ins	novel	*D239Efs32**	0.04
BLCA	chr8	119564870	Silent	rs547371219	F739F	0.12
BLCA	chr8	119586290	Silent	novel	F421F	0.06
BLCA	chr8	119593849	Silent	novel	P328P	0.08
BLCA	chr8	119607975	Splice_Region	NA	L260L	0.53
BLCA	chr8	119626716	Silent	novel	L47L	0.36
BLCA	chr8	119638772	Silent	rs761158154	R3R	0.33
BLCA	chr8	119616274	Silent	novel	G256G	0.32
BRCA	chr8	119584011	Missense_Mutation	NA	C469F	0.2
BRCA	chr8	119557528	Missense_Mutation	NA	E862G	0.51	Endonuclease_NS
BRCA	chr8	119590528	Missense_Mutation	NA	S395F	0.19
BRCA	chr8	119586259	Missense_Mutation	NA	R432C	0.29
BRCA	chr8	119595876	Intron	NA		0.21
BRCA	chr8	119593836	Missense_Mutation	novel	D333N	0.35
BRCA	chr8	119586263	Silent	NA	P430P	0.21
BRCA	chr8	119582464	Missense_Mutation	novel	S561F	0.25
BRCA	chr8	119617215	Missense_Mutation	rs746187066	M202I	0.18
BRCA	chr8	119569276	Missense_Mutation	NA	K671T	0.15	Endonuclease_NS
BRCA	chr8	119590532	Nonsense_Mutation	NA	R394*	0.14
BRCA	chr8	119595902	Intron	NA		0.32
BRCA	chr8	119638466	Missense_Mutation	rs746442526	R32Q	0.25
BRCA	chr8	119590601	Missense_Mutation	NA	E371Q	0.18
BRCA	chr8	119582548	Missense_Mutation	NA	H533R	0.18
CESC	chr8	119569367	Missense_Mutation	NA	E641Q	0.14
CESC	chr8	119557569	Missense_Mutation	NA	E848D	0.22	Endonuclease_NS
CESC	chr8	119584017	Missense_Mutation	rs567059238	G467E	0.31
CESC	chr8	119562999	Missense_Mutation	novel	S760N	0.17	Endonuclease_NS
CESC	chr8	119583747	Missense_Mutation	novel	E505K	0.37
CESC	chr8	119616353	Missense_Mutation	NA	G230V	0.26
CESC	chr8	119593751	Splice_Site	novel	X361_splice	0.34
CESC	chr8	119570828	Silent	NA	L598L	0.33
CESC	chr8	119638503	Missense_Mutation	rs775542252	V20I	0.24
CESC	chr8	119621492	Missense_Mutation	novel	R107T	0.42
CESC	chr8	119583985	Missense_Mutation	novel	D478H	0.47
CESC	chr8	119616312	Silent	rs767223101	L244L	0.2
COAD	chr8	119590606	Missense_Mutation	NA	R369I	0.41
COAD	chr8	119596000	Intron	NA		0.38
COAD	chr8	119584005	Frame_Shift_Del	NA	*F471Sfs19**	0.34
COAD	chr8	119590618	Missense_Mutation	novel	V365A	0.12
COAD	chr8	119590532	Nonsense_Mutation	NA	R394*	0.28
COAD	chr8	119582600	Missense_Mutation	NA	L516I	0.21
COAD	chr8	119595896	Intron	novel		0.44
COAD	chr8	119619296	Missense_Mutation	novel	H143N	0.06
COAD	chr8	119601416	Missense_Mutation	novel	T294A	0.18
COAD	chr8	119595851	Intron	NA		0.39
COAD	chr8	119590592	Missense_Mutation	novel	S374G	0.08
COAD	chr8	119569356	Silent	rs566612458	S644S	0.41
COAD	chr8	119617556	Missense_Mutation	rs767465276	R163C	0.37
COAD	chr8	119557631	Missense_Mutation	rs752514086	R828C	0.27	Endonuclease_NS
COAD	chr8	119569297	Missense_Mutation	novel	S664N	0.07	Endonuclease_NS
COAD	chr8	119586192	Missense_Mutation	NA	V454A	0.19
COAD	chr8	119593831	Missense_Mutation	novel	K334N	0.16
COAD	chr8	119626617	Missense_Mutation	novel	C80W	0.24
COAD	chr8	119595905	Intron	NA		0.25
COAD	chr8	119626574	Missense_Mutation	NA	L95V	0.38
COAD	chr8	119601450	Silent	rs367992382	H282H	0.22
DLBC	chr8	119619249	Silent	novel	P158P	0.44
ESCA	chr8	119595924	Intron	novel		0.17
ESCA	chr8	119564891	Silent	rs755611358	N732N	0.26
GBM	chr8	119638819	5'UTR	novel		0.14
GBM	chr8	119557590	Silent	NA	K841K	0.4
GBM	chr8	119638425	Missense_Mutation	novel	V46L	0.12
GBM	chr8	119617556	Missense_Mutation	rs767465276	R163C	0.23
GBM	chr8	119586224	Silent	novel	D443D	0.15
GBM	chr8	119586288	Missense_Mutation	rs750980378	K422R	0.18
GBM	chr8	119586205	Missense_Mutation	NA	R450C	0.42
GBM	chr8	119595865	Intron	rs759168793		0.23
GBM	chr8	119595970	Intron	novel		0.1
GBM	chr8	119617519	Missense_Mutation	rs776304212	R175H	0.47
GBM	chr8	119616276	Missense_Mutation	NA	G256R	0.11
HNSC	chr8	119617496	Missense_Mutation	novel	S183C	0.27
HNSC	chr8	119595891	Intron	novel		0.35
HNSC	chr8	119564904	Missense_Mutation	novel	R728K	0.29	Endonuclease_NS
HNSC	chr8	119583719	Missense_Mutation	novel	C514S	0.13
HNSC	chr8	119617539	Missense_Mutation	novel	I168M	0.31
HNSC	chr8	119583964	Nonsense_Mutation	novel	Q485*	0.25
HNSC	chr8	119557656	Silent	novel	L819L	0.09
HNSC	chr8	119638467	Missense_Mutation	rs138726849	R32G	0.15
HNSC	chr8	119621486	Missense_Mutation	novel	G109E	0.15
HNSC	chr8	119593773	Missense_Mutation	rs563432387	V354I	0.08
HNSC	chr8	119590504	Splice_Site	novel	X403_splice	0.41
HNSC	chr8	119617222	Missense_Mutation	NA	P200L	0.13
KICH	chr8	119593761	Missense_Mutation	NA	G358R	0.32
KICH	chr8	119616303	Nonsense_Mutation	rs776028490	R247*	0.34
KIRC	chr8	119564904	Missense_Mutation	novel	R728I	0.04	Endonuclease_NS
KIRC	chr8	119638832	5'UTR	rs779811974		0.43
KIRC	chr8	119621463	Missense_Mutation	NA	A117S	0.17
KIRC	chr8	119557665	Silent	novel	V816V	0.34
KIRP	chr8	119638816	5'UTR	novel		0.39
LAML	chr8	119593789	Silent	novel	L348L	0.15
LAML	chr8	119562882	Missense_Mutation	rs745564919	R799Q	0.13	Endonuclease_NS
LGG	chr8	119616268	Missense_Mutation	NA	Q258H	0.13
LGG	chr8	119584043	Silent	NA	P458P	0.52
LGG	chr8	119595989	Intron	novel		0.27
LGG	chr8	119600750	Splice_Region	novel	R300R	0.25
LIHC	chr8	119562888	Missense_Mutation	novel	P797R	0.46	Endonuclease_NS
LIHC	chr8	119582574	Silent	NA	N524N	0.37
LIHC	chr8	119616311	Missense_Mutation	NA	L244Q	0.48
LUAD	chr8	119621427	Missense_Mutation	novel	D129Y	0.15
LUAD	chr8	119590528	Missense_Mutation	NA	S395Y	0.65
LUAD	chr8	119563014	Splice_Site	novel	X755_splice	0.19
LUAD	chr8	119601429	Missense_Mutation	novel	I289M	0.27
LUAD	chr8	119595907	Intron	NA		0.25
LUAD	chr8	119595973	Intron	novel		0.47
LUAD	chr8	119626701	Missense_Mutation	NA	W52C	0.08
LUAD	chr8	119582448	Silent	NA	G566G	0.15
LUAD	chr8	119557664	Missense_Mutation	NA	E817K	0.04	Endonuclease_NS
LUAD	chr8	119638817	5'UTR	novel		0.1
LUAD	chr8	119617242	Missense_Mutation	NA	R193S	0.2
LUAD	chr8	119568237	Nonsense_Mutation	novel	*P690Hfs7**	0.03	Endonuclease_NS
LUAD	chr8	119569307	Missense_Mutation	novel	P661T	0.27
LUAD	chr8	119626572	Silent	NA	L95L	0.21
LUAD	chr8	119601409	Missense_Mutation	NA	P296Q	0.55
LUAD	chr8	119619304	Missense_Mutation	NA	G140E	0.06
LUAD	chr8	119583959	Splice_Region	novel		0.23
LUAD	chr8	119582497	Missense_Mutation	novel	R550T	0.25
LUAD	chr8	119601411	Silent	novel	L295L	0.14
LUAD	chr8	119601413	Missense_Mutation	novel	L295M	0.14
LUAD	chr8	119600682	Missense_Mutation	NA	P323H	0.14
LUAD	chr8	119584044	Missense_Mutation	NA	P458L	0.09
LUAD	chr8	119564953	Frame_Shift_Del	novel	*V712Sfs10**	0.24	Endonuclease_NS
LUAD	chr8	119562868	Nonsense_Mutation	novel	E804*	0.45	Endonuclease_NS
LUAD	chr8	119580116	Missense_Mutation	novel	E594Q	0.42
LUAD	chr8	119593774	Missense_Mutation	novel	N353K	0.09
LUAD	chr8	119568206	Silent	novel	T700T	0.14
LUAD	chr8	119617231	Missense_Mutation	NA	T197I	0.21
LUAD	chr8	119563013	Nonsense_Mutation	novel	*Y756Wfs4**	0.09	Endonuclease_NS
LUAD	chr8	119570843	Splice_Region	novel		0.11
LUSC	chr8	119616314	Missense_Mutation	NA	H243R	0.27
LUSC	chr8	119638812	5'UTR	novel		0.67
LUSC	chr8	119557573	Missense_Mutation	novel	P847Q	0.41	Endonuclease_NS
LUSC	chr8	119616378	Missense_Mutation	NA	Y222H	0.65
LUSC	chr8	119586234	Missense_Mutation	novel	R440K	0.29
LUSC	chr8	119582517	Silent	NA	T543T	0.18
LUSC	chr8	119582585	Missense_Mutation	rs752537154	P521S	0.27
LUSC	chr8	119564955	Missense_Mutation	novel	R711Q	0.23	Endonuclease_NS
LUSC	chr8	119582507	Missense_Mutation	novel	E547K	0.42
LUSC	chr8	119595849	Intron	novel		0.08
LUSC	chr8	119621435	Missense_Mutation	NA	A126G	0.42
LUSC	chr8	119580120	Silent	NA	T592T	0.3
LUSC	chr8	119557545	Silent	NA	L856L	0.15
LUSC	chr8	119580141	Silent	novel	R585R	0.16
LUSC	chr8	119586197	Missense_Mutation	novel	W452C	0.07
LUSC	chr8	119586204	Missense_Mutation	novel	R450L	0.37
LUSC	chr8	119569257	Silent	NA	S677S	0.43
LUSC	chr8	119590625	Missense_Mutation	NA	E363K	0.38
LUSC	chr8	119557683	Silent	novel	E810E	0.25
LUSC	chr8	119582493	Silent	novel	P551P	0.5
LUSC	chr8	119607965	Missense_Mutation	novel	A264P	0.54
LUSC	chr8	119593758	Missense_Mutation	NA	D359N	0.19
LUSC	chr8	119582484	Silent	novel	P554P	0.43
LUSC	chr8	119601445	Missense_Mutation	novel	R284L	0.18
LUSC	chr8	119593756	Missense_Mutation	novel	D359E	0.06
LUSC	chr8	119600745	Nonsense_Mutation	novel	S302*	0.15
LUSC	chr8	119601451	Missense_Mutation	novel	H282R	0.12
LUSC	chr8	119582579	Missense_Mutation	NA	P523A	0.11
LUSC	chr8	119583728	Missense_Mutation	novel	N511I	0.06
LUSC	chr8	119557640	Missense_Mutation	novel	A825P	0.24	Endonuclease_NS
LUSC	chr8	119562883	Missense_Mutation	rs370024218	R799W	0.24	Endonuclease_NS
OV	chr8	119616386	Splice_Site	novel	X220_splice	0.26
OV	chr8	119638486	Nonsense_Mutation	novel	C25*	0.06
OV	chr8	119562916	Missense_Mutation	NA	P788T	0.13	Endonuclease_NS
OV	chr8	119562879	Missense_Mutation	novel	P800L	0.23	Endonuclease_NS
OV	chr8	119563010	Nonsense_Mutation	novel	Y756*	0.05	Endonuclease_NS
OV	chr8	119562883	Missense_Mutation	rs370024218	R799W	0.39	Endonuclease_NS
OV	chr8	119617468	Missense_Mutation	novel	L192Q	0.18
OV	chr8	119583769	Nonsense_Mutation	novel	Y497*	0.24
OV	chr8	119621518	Splice_Region	NA	A98A	0.14
PAAD	chr8	119557689	Missense_Mutation	rs780642132	S808R	0.16	Endonuclease_NS
PAAD	chr8	119562889	Missense_Mutation	novel	P797S	0.17	Endonuclease_NS
PAAD	chr8	119569328	Missense_Mutation	rs138793770	R654W	0.16
PAAD	chr8	119621404	Silent	novel	V136V	0.31
PRAD	chr8	119562871	Nonsense_Mutation	NA	E803*	0.05	Endonuclease_NS
PRAD	chr8	119595866	Intron	rs142695308		0.04
PRAD	chr8	119586197	Nonsense_Mutation	novel	W452*	0.32
PRAD	chr8	119619297	Silent	rs200364301	S142S	0.31
READ	chr8	119562872	Silent	rs61740048	N802N	0.53
READ	chr8	119590532	Nonsense_Mutation	NA	R394*	0.41
READ	chr8	119570844	Splice_Region	novel		0.63
READ	chr8	119586304	Missense_Mutation	novel	P417T	0.04
READ	chr8	119593858	Missense_Mutation	novel	M325I	0.43
READ	chr8	119617536	Missense_Mutation	novel	F169L	0.38
READ	chr8	119638425	Missense_Mutation	NA	V46M	0.34
READ	chr8	119563003	Missense_Mutation	NA	G759S	0.43	Endonuclease_NS
READ	chr8	119595899	Intron	NA		0.17
READ	chr8	119595998	Intron	NA		0.35
READ	chr8	119621466	Missense_Mutation	NA	N116H	0.5
SARC	chr8	119586288	Frame_Shift_Del	novel	*K422Sfs4**	0.26
SARC	chr8	119617210	Missense_Mutation	rs754090722	P204L	0.33
SKCM	chr8	119617534	Missense_Mutation	NA	S170F	0.24
SKCM	chr8	119607960	Silent	NA	T265T	0.17
SKCM	chr8	119569306	Missense_Mutation	rs375770524	P661L	0.35
SKCM	chr8	119590532	Nonsense_Mutation	NA	R394*	0.35
SKCM	chr8	119638794	5'UTR	novel		0.42
SKCM	chr8	119590532	Nonsense_Mutation	NA	R394*	0.21
SKCM	chr8	119595942	Intron	NA		0.43
SKCM	chr8	119626705	Missense_Mutation	NA	P51L	0.28
SKCM	chr8	119638520	Missense_Mutation	NA	S14F	0.19
SKCM	chr8	119557457	3'Flank	novel		0.36
SKCM	chr8	119557496	3'Flank	novel		0.11
SKCM	chr8	119617191	Silent	NA	T210T	0.42
SKCM	chr8	119600692	Missense_Mutation	novel	P320S	0.07
SKCM	chr8	119580116	Missense_Mutation	novel	E594K	0.46
SKCM	chr8	119593809	Missense_Mutation	novel	G342R	0.48
SKCM	chr8	119595907	Intron	NA		0.38
SKCM	chr8	119617534	Missense_Mutation	NA	S170F	0.31
SKCM	chr8	119562911	Silent	NA	L789L	0.44
STAD	chr8	119595921	Intron	novel		0.04
STAD	chr8	119600742	Missense_Mutation	NA	V303A	0.22
STAD	chr8	119569359	Silent	novel	S643S	0.07
STAD	chr8	119582582	Missense_Mutation	rs764975897	A522T	0.13
STAD	chr8	119601460	Missense_Mutation	NA	V279A	0.17
STAD	chr8	119569284	Missense_Mutation	novel	L668F	0.05	Endonuclease_NS
STAD	chr8	119626704	Frame_Shift_Del	novel	*W52Gfs44**	0.25
STAD	chr8	119570821	Nonsense_Mutation	rs764313249	R601*	0.15
STAD	chr8	119600723	Silent	novel	E309E	0.27
STAD	chr8	119607965	Missense_Mutation	novel	A264T	0.25
STAD	chr8	119595865	Intron	rs759168793		0.23
STAD	chr8	119595948	Intron	novel		0.29
STAD	chr8	119583774	Missense_Mutation	NA	K496E	0.13
STAD	chr8	119638448	Missense_Mutation	NA	G38E	0.1
STAD	chr8	119564895	Missense_Mutation	NA	V731G	0.1	Endonuclease_NS
STAD	chr8	119569341	Silent	NA	L649L	0.22
STAD	chr8	119583960	Splice_Site	NA	X485_splice	0.04
STAD	chr8	119586246	Missense_Mutation	NA	A436V	0.17
STAD	chr8	119586305	Frame_Shift_Del	novel	*K416Nfs10**	0.1
THCA	chr8	119562969	Missense_Mutation	NA	S770N	0.1	Endonuclease_NS
THCA	chr8	119638492	Silent	NA	N23N	0.23
THCA	chr8	119562872	Missense_Mutation	NA	N802K	0.09	Endonuclease_NS
UCEC	chr8	119562918	Missense_Mutation	NA	G787V	0.4	Endonuclease_NS
UCEC	chr8	119619297	Silent	rs200364301	S142S	0.3
UCEC	chr8	119638499	Missense_Mutation	NA	G21E	0.35
UCEC	chr8	119562931	Missense_Mutation	rs201911203	D783N	0.31	Endonuclease_NS
UCEC	chr8	119582594	Missense_Mutation	novel	G518R	0.06
UCEC	chr8	119600748	Missense_Mutation	novel	P301H	0.16
UCEC	chr8	119621461	Silent	novel	A117A	0.3
UCEC	chr8	119621469	Nonsense_Mutation	NA	E115*	0.26
UCEC	chr8	119590537	Missense_Mutation	NA	R392I	0.38
UCEC	chr8	119619297	Silent	rs200364301	S142S	0.42
UCEC	chr8	119590609	Missense_Mutation	NA	D368G	0.19
UCEC	chr8	119596000	Intron	NA		0.07
UCEC	chr8	119616309	Nonsense_Mutation	rs761562708	R245*	0.34
UCEC	chr8	119593827	Missense_Mutation	novel	V336L	0.48
UCEC	chr8	119583739	Silent	rs145038215	I507I	0.44
UCEC	chr8	119586303	In_Frame_Ins	novel	P417delinsHTHT	0.04
UCEC	chr8	119562924	Missense_Mutation	NA	C785Y	0.31	Endonuclease_NS
UCEC	chr8	119638466	Missense_Mutation	rs746442526	R32Q	0.24
UCEC	chr8	119593854	Missense_Mutation	novel	N327H	0.48
UCEC	chr8	119617498	Missense_Mutation	rs757880591	G182D	0.43
UCEC	chr8	119583800	Missense_Mutation	novel	V487A	0.45
UCEC	chr8	119638791	5'UTR	novel		0.16
UCEC	chr8	119586234	Missense_Mutation	novel	R440I	0.82
UCEC	chr8	119593762	Silent	rs747280674	V357V	0.24
UCEC	chr8	119564891	Silent	rs755611358	N732N	0.33
UCEC	chr8	119593847	Splice_Site	novel	X325_splice	0.04
UCEC	chr8	119569247	Missense_Mutation	novel	L681I	0.37	Endonuclease_NS
UCEC	chr8	119569260	Missense_Mutation	novel	M676I	0.31	Endonuclease_NS
UCEC	chr8	119583964	Nonsense_Mutation	novel	Q485*	0.44
UCEC	chr8	119557493	3'Flank	novel		0.2
UCEC	chr8	119586303	Frame_Shift_Ins	novel	*P417Hfs11**	0.06
UCEC	chr8	119564921	Missense_Mutation	NA	K722N	0.38	Endonuclease_NS
UCEC	chr8	119590537	Missense_Mutation	NA	R392I	0.43
UCEC	chr8	119617506	Missense_Mutation	NA	M179I	0.35
UCEC	chr8	119587073	Missense_Mutation	novel	D404Y	0.38
UCEC	chr8	119616298	Missense_Mutation	novel	E248D	0.29
UCEC	chr8	119619257	Nonsense_Mutation	novel	E156*	0.35
UCEC	chr8	119638466	Missense_Mutation	rs746442526	R32Q	0.24
UCEC	chr8	119626668	Silent	novel	C63C	0.15
UCEC	chr8	119570814	Missense_Mutation	NA	A603V	0.28
UCEC	chr8	119557661	Nonsense_Mutation	novel	E818*	0.46	Endonuclease_NS
UCEC	chr8	119590606	Missense_Mutation	NA	R369I	0.16
UCEC	chr8	119595965	Intron	novel		0.22
UCEC	chr8	119619297	Silent	rs200364301	S142S	0.42
UCEC	chr8	119626688	Missense_Mutation	rs771405069	G57R	0.25
UCEC	chr8	119621459	Missense_Mutation	NA	C118Y	0.1
UCEC	chr8	119557533	Silent	rs529559244	E860E	0.4
UCEC	chr8	119595865	Intron	rs759168793		0.32
UCEC	chr8	119601425	Nonsense_Mutation	novel	Q291*	0.22
UCEC	chr8	119586201	Missense_Mutation	novel	R451I	0.08
UCEC	chr8	119557661	Nonsense_Mutation	novel	E818*	0.28	Endonuclease_NS
UCEC	chr8	119580143	Missense_Mutation	rs147145968	R585W	0.41
UCEC	chr8	119595902	Intron	NA		0.33
UCEC	chr8	119600711	Missense_Mutation	NA	F313L	0.14
UCEC	chr8	119619297	Silent	rs200364301	S142S	0.36
UCEC	chr8	119621484	Nonsense_Mutation	NA	E110*	0.21
UCEC	chr8	119638459	Missense_Mutation	novel	K34N	0.36
UCEC	chr8	119586305	Frame_Shift_Del	novel	*K416Nfs10**	0.24
UCEC	chr8	119569368	Frame_Shift_Ins	novel	*E641Dfs12**	0.07
UCEC	chr8	119582475	Missense_Mutation	novel	M557I	0.18
UCEC	chr8	119587070	Missense_Mutation	NA	P405S	0.13
UCEC	chr8	119557439	3'Flank	novel		0.45
UCEC	chr8	119572223	Intron	NA		0.49
UCEC	chr8	119595902	Intron	NA		0.48
UCEC	chr8	119557530	Silent	rs139553486	S861S	0.24
UCEC	chr8	119564921	Missense_Mutation	NA	K722N	0.34	Endonuclease_NS
UCEC	chr8	119582553	Silent	NA	L531L	0.34
UCEC	chr8	119584028	Missense_Mutation	NA	K463N	0.3
UCEC	chr8	119557307	3'Flank	novel		0.18
UCEC	chr8	119569331	Missense_Mutation	rs748275252	V653I	0.2
UCEC	chr8	119626708	Missense_Mutation	novel	S50Y	0.23
UCEC	chr8	119572194	Intron	novel		0.39
UCEC	chr8	119564956	Splice_Site	NA	X711_splice	0.13
UCEC	chr8	119569328	Missense_Mutation	rs138793770	R654W	0.41
UCEC	chr8	119586275	Missense_Mutation	novel	K426N	0.06
UCEC	chr8	119569253	Missense_Mutation	NA	G679R	0.31	Endonuclease_NS
UCEC	chr8	119557398	3'Flank	novel		0.27
UCEC	chr8	119557630	Missense_Mutation	rs759316715	R828H	0.25	Endonuclease_NS
UCS	chr8	119587069	Missense_Mutation	novel	P405R	0.26

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	AMP	0.2083	0.018626
KIRC	AMP	0.1174	0.15559
LGG	AMP	0.1676	6.7949e-16
LIHC	AMP	0.6135	1.1795e-21
SARC	AMP	0.2763	0.18425
SKCM	AMP	0.4441	2.8957e-05
TGCT	AMP	0.5867	0.13696
THCA	DEL	0.01	0.038162
UVM	AMP	0.7375	8.8879e-13

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0019	Kaplan-Meier Survival Analysis
STAD	0.042	Kaplan-Meier Survival Analysis
SKCM	0.004	Kaplan-Meier Survival Analysis
LUSC	0.00065	Kaplan-Meier Survival Analysis
PAAD	0.0001	Kaplan-Meier Survival Analysis
PCPG	0.03	Kaplan-Meier Survival Analysis
LAML	0.0015	Kaplan-Meier Survival Analysis
KICH	0.02	Kaplan-Meier Survival Analysis
LIHC	0.037	Kaplan-Meier Survival Analysis
LGG	0.05	Kaplan-Meier Survival Analysis
LUAD	0.029	Kaplan-Meier Survival Analysis
UVM	0.00013	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000136960 (Gene tree)
Gene ID: 5168
Gene Symbol: ENPP2
Alias: ATX|PD-IALPHA|PDNP2
Full Name: ectonucleotide pyrophosphatase/phosphodiesterase 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 116,377 bases
Position: chr8:119,557,077-119,673,453
Accession: 3357
RBP type: canonical RBP
Summary: The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000429476	Endonuclease_NS	PF01223.23	5.7e-10	1	1
ENSP00000075322	Endonuclease_NS	PF01223.23	1.9e-09	1	1
ENSP00000403315	Endonuclease_NS	PF01223.23	2e-09	1	1
ENSP00000428291	Endonuclease_NS	PF01223.23	2e-09	1	1
ENSP00000259486	Endonuclease_NS	PF01223.23	2.1e-09	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
27784781	Autotaxin Expression Is Regulated at the Post-transcriptional Level by the RNA-binding Proteins HuR and AUF1.	J Biol Chem	2016 Dec 9	Sun S	-
21209002	TonEBP stimulates multiple cellular pathways for adaptation to hypertonic stress: organic osmolyte-dependent and -independent pathways.	Am J Physiol Renal Physiol	2011 Mar	Lee SD	doi: 10.1152/ajprenal.00227.2010

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000259486	ENPP2-202	3233	XM_006716584	ENSP00000259486	915 (aa)	XP_006716647	Q13822
ENST00000523861	ENPP2-209	3647	-	-	- (aa)	-	-
ENST00000520066	ENPP2-206	769	-	ENSP00000428304	245 (aa)	-	E5RJ49
ENST00000522826	ENPP2-208	2667	XM_017013572	ENSP00000428291	888 (aa)	XP_016869061	Q13822
ENST00000075322	ENPP2-201	2651	XM_017013575	ENSP00000075322	863 (aa)	XP_016869064	Q13822
ENST00000518958	ENPP2-205	991	-	ENSP00000429447	162 (aa)	-	E5RIB9
ENST00000427067	ENPP2-203	3271	XM_017013573	ENSP00000403315	884 (aa)	XP_016869062	E7EUF1
ENST00000522167	ENPP2-207	1695	-	ENSP00000429476	498 (aa)	-	E5RIA2
ENST00000518109	ENPP2-204	666	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000136960's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00565	Ether lipid metabolism	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000136960	Body Height	6E-6	21998595

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000136960	rs7007970	8	119635689	C	Height	21998595	[0.023-0.059] unit decrease	0.041	EFO_0004339
ENSG00000136960	rs10283100	8	119583783	?	Lung function (FVC)	30595370			EFO_0004312

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000136960's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000136960	ENPP2	100	69.400	ENSAPOG00000020360	enpp2	99	69.123	Acanthochromis_polyacanthus
ENSG00000136960	ENPP2	98	61.229	ENSAPOG00000000191	-	94	60.296	Acanthochromis_polyacanthus
ENSG00000136960	ENPP2	100	95.219	ENSAMEG00000004213	ENPP2	100	95.796	Ailuropoda_melanoleuca
ENSG00000136960	ENPP2	100	66.865	ENSACIG00000009963	enpp2	99	65.304	Amphilophus_citrinellus
ENSG00000136960	ENPP2	83	74.208	ENSACIG00000012098	-	93	74.208	Amphilophus_citrinellus
ENSG00000136960	ENPP2	100	69.062	ENSAOCG00000002592	enpp2	100	69.062	Amphiprion_ocellaris
ENSG00000136960	ENPP2	98	60.599	ENSAOCG00000009410	-	98	61.566	Amphiprion_ocellaris
ENSG00000136960	ENPP2	98	60.599	ENSAPEG00000010026	-	98	61.566	Amphiprion_percula
ENSG00000136960	ENPP2	100	69.062	ENSAPEG00000004627	enpp2	100	69.062	Amphiprion_percula
ENSG00000136960	ENPP2	100	69.600	ENSATEG00000024970	enpp2	96	78.481	Anabas_testudineus
ENSG00000136960	ENPP2	99	62.251	ENSATEG00000014068	-	99	62.251	Anabas_testudineus
ENSG00000136960	ENPP2	100	83.297	ENSAPLG00000006897	ENPP2	100	83.297	Anas_platyrhynchos
ENSG00000136960	ENPP2	100	80.962	ENSACAG00000008571	ENPP2	100	78.753	Anolis_carolinensis
ENSG00000136960	ENPP2	100	97.012	ENSANAG00000026872	ENPP2	100	95.243	Aotus_nancymaae
ENSG00000136960	ENPP2	98	61.111	ENSACLG00000012318	-	98	61.111	Astatotilapia_calliptera
ENSG00000136960	ENPP2	100	68.072	ENSACLG00000004760	enpp2	99	67.409	Astatotilapia_calliptera
ENSG00000136960	ENPP2	99	60.385	ENSAMXG00000031220	-	99	62.914	Astyanax_mexicanus
ENSG00000136960	ENPP2	100	68.273	ENSAMXG00000007268	enpp2	99	68.038	Astyanax_mexicanus
ENSG00000136960	ENPP2	100	93.694	ENSBTAG00000013165	ENPP2	100	93.694	Bos_taurus
ENSG00000136960	ENPP2	100	97.172	ENSCJAG00000005628	ENPP2	100	97.172	Callithrix_jacchus
ENSG00000136960	ENPP2	100	95.608	ENSCAFG00000000865	ENPP2	100	95.608	Canis_familiaris
ENSG00000136960	ENPP2	100	95.738	ENSCAFG00020004366	ENPP2	100	95.738	Canis_lupus_dingo
ENSG00000136960	ENPP2	100	93.048	ENSCHIG00000018203	ENPP2	100	93.048	Capra_hircus
ENSG00000136960	ENPP2	100	96.016	ENSTSYG00000001901	ENPP2	100	95.944	Carlito_syrichta
ENSG00000136960	ENPP2	99	80.046	ENSCAPG00000013815	ENPP2	99	80.046	Cavia_aperea
ENSG00000136960	ENPP2	100	96.833	ENSCCAG00000029009	ENPP2	100	97.124	Cebus_capucinus
ENSG00000136960	ENPP2	100	99.126	ENSCATG00000041981	ENPP2	100	99.126	Cercocebus_atys
ENSG00000136960	ENPP2	100	94.622	ENSCLAG00000006503	ENPP2	100	93.224	Chinchilla_lanigera
ENSG00000136960	ENPP2	99	98.125	ENSCSAG00000010835	ENPP2	100	96.170	Chlorocebus_sabaeus
ENSG00000136960	ENPP2	99	86.250	ENSCHOG00000004509	ENPP2	91	92.937	Choloepus_hoffmanni
ENSG00000136960	ENPP2	99	84.977	ENSCPBG00000015362	ENPP2	99	84.977	Chrysemys_picta_bellii
ENSG00000136960	ENPP2	100	98.798	ENSCANG00000033876	ENPP2	100	98.798	Colobus_angolensis_palliatus
ENSG00000136960	ENPP2	100	92.700	ENSCGRG00001005486	Enpp2	100	92.700	Cricetulus_griseus_chok1gshd
ENSG00000136960	ENPP2	100	94.024	ENSCGRG00000011939	Enpp2	100	93.403	Cricetulus_griseus_crigri
ENSG00000136960	ENPP2	99	66.473	ENSCSEG00000010903	enpp2	98	67.754	Cynoglossus_semilaevis
ENSG00000136960	ENPP2	99	59.700	ENSCSEG00000018526	-	98	60.961	Cynoglossus_semilaevis
ENSG00000136960	ENPP2	99	56.313	ENSCVAG00000002583	-	98	59.927	Cyprinodon_variegatus
ENSG00000136960	ENPP2	100	59.082	ENSCVAG00000000682	enpp2	100	63.138	Cyprinodon_variegatus
ENSG00000136960	ENPP2	100	67.671	ENSDARG00000011257	enpp2	99	66.432	Danio_rerio
ENSG00000136960	ENPP2	100	93.511	ENSDNOG00000005336	ENPP2	100	93.511	Dasypus_novemcinctus
ENSG00000136960	ENPP2	100	95.045	ENSDORG00000004750	Enpp2	100	95.045	Dipodomys_ordii
ENSG00000136960	ENPP2	100	96.787	ENSEASG00005023034	ENPP2	100	96.175	Equus_asinus_asinus
ENSG00000136960	ENPP2	100	96.066	ENSECAG00000003776	ENPP2	100	96.066	Equus_caballus
ENSG00000136960	ENPP2	96	90.432	ENSEEUG00000000262	ENPP2	100	84.044	Erinaceus_europaeus
ENSG00000136960	ENPP2	99	63.902	ENSELUG00000018089	-	99	64.136	Esox_lucius
ENSG00000136960	ENPP2	100	62.124	ENSELUG00000023691	enpp2	97	68.914	Esox_lucius
ENSG00000136960	ENPP2	100	96.833	ENSFCAG00000010937	ENPP2	100	96.833	Felis_catus
ENSG00000136960	ENPP2	100	84.046	ENSFALG00000002338	ENPP2	100	84.046	Ficedula_albicollis
ENSG00000136960	ENPP2	100	89.759	ENSFDAG00000016931	ENPP2	100	89.943	Fukomys_damarensis
ENSG00000136960	ENPP2	94	61.444	ENSFHEG00000013336	-	96	61.444	Fundulus_heteroclitus
ENSG00000136960	ENPP2	100	83.565	ENSGALG00000032746	ENPP2	100	83.565	Gallus_gallus
ENSG00000136960	ENPP2	94	62.822	ENSGAFG00000001851	-	98	60.838	Gambusia_affinis
ENSG00000136960	ENPP2	99	60.047	ENSGACG00000009688	-	99	60.047	Gasterosteus_aculeatus
ENSG00000136960	ENPP2	100	68.600	ENSGACG00000004492	enpp2	99	70.988	Gasterosteus_aculeatus
ENSG00000136960	ENPP2	100	84.589	ENSGAGG00000002768	ENPP2	100	84.589	Gopherus_agassizii
ENSG00000136960	ENPP2	100	99.434	ENSGGOG00000002873	ENPP2	100	99.434	Gorilla_gorilla
ENSG00000136960	ENPP2	99	60.514	ENSHBUG00000005834	-	99	60.514	Haplochromis_burtoni
ENSG00000136960	ENPP2	100	68.200	ENSHBUG00000010934	enpp2	99	67.719	Haplochromis_burtoni
ENSG00000136960	ENPP2	100	92.972	ENSHGLG00000009011	ENPP2	100	90.820	Heterocephalus_glaber_female
ENSG00000136960	ENPP2	100	90.258	ENSHGLG00100007872	ENPP2	95	89.085	Heterocephalus_glaber_male
ENSG00000136960	ENPP2	100	60.714	ENSHCOG00000021118	enpp2	95	63.559	Hippocampus_comes
ENSG00000136960	ENPP2	100	65.530	ENSIPUG00000001082	ENPP2	99	66.515	Ictalurus_punctatus
ENSG00000136960	ENPP2	98	60.967	ENSIPUG00000007773	-	99	60.443	Ictalurus_punctatus
ENSG00000136960	ENPP2	100	96.509	ENSSTOG00000001935	ENPP2	100	96.509	Ictidomys_tridecemlineatus
ENSG00000136960	ENPP2	100	93.989	ENSJJAG00000001919	Enpp2	100	93.989	Jaculus_jaculus
ENSG00000136960	ENPP2	99	57.143	ENSKMAG00000007627	-	98	62.039	Kryptolebias_marmoratus
ENSG00000136960	ENPP2	96	62.244	ENSLBEG00000026306	-	98	60.488	Labrus_bergylta
ENSG00000136960	ENPP2	99	76.250	ENSLACG00000007935	ENPP2	100	74.302	Latimeria_chalumnae
ENSG00000136960	ENPP2	100	74.498	ENSLOCG00000009138	enpp2	99	63.353	Lepisosteus_oculatus
ENSG00000136960	ENPP2	100	92.629	ENSLAFG00000017681	ENPP2	100	91.784	Loxodonta_africana
ENSG00000136960	ENPP2	100	99.126	ENSMFAG00000002827	ENPP2	100	99.126	Macaca_fascicularis
ENSG00000136960	ENPP2	100	99.126	ENSMMUG00000004903	ENPP2	100	99.126	Macaca_mulatta
ENSG00000136960	ENPP2	100	99.099	ENSMNEG00000031748	ENPP2	100	99.099	Macaca_nemestrina
ENSG00000136960	ENPP2	100	99.016	ENSMLEG00000034395	ENPP2	100	99.016	Mandrillus_leucophaeus
ENSG00000136960	ENPP2	98	61.493	ENSMAMG00000020070	-	98	61.493	Mastacembelus_armatus
ENSG00000136960	ENPP2	99	66.742	ENSMAMG00000005496	enpp2	100	66.071	Mastacembelus_armatus
ENSG00000136960	ENPP2	98	60.993	ENSMZEG00005027057	-	98	60.993	Maylandia_zebra
ENSG00000136960	ENPP2	100	64.484	ENSMZEG00005025368	enpp2	100	64.484	Maylandia_zebra
ENSG00000136960	ENPP2	100	81.777	ENSMGAG00000012517	ENPP2	100	81.777	Meleagris_gallopavo
ENSG00000136960	ENPP2	100	95.382	ENSMAUG00000014910	-	100	95.382	Mesocricetus_auratus
ENSG00000136960	ENPP2	100	97.219	ENSMICG00000017293	ENPP2	100	97.219	Microcebus_murinus
ENSG00000136960	ENPP2	100	94.322	ENSMOCG00000001571	Enpp2	100	94.322	Microtus_ochrogaster
ENSG00000136960	ENPP2	100	65.094	ENSMMOG00000003147	enpp2	95	68.957	Mola_mola
ENSG00000136960	ENPP2	94	61.444	ENSMMOG00000016269	-	98	61.444	Mola_mola
ENSG00000136960	ENPP2	100	88.446	ENSMODG00000003977	ENPP2	99	84.965	Monodelphis_domestica
ENSG00000136960	ENPP2	100	67.600	ENSMALG00000012515	enpp2	98	69.636	Monopterus_albus
ENSG00000136960	ENPP2	95	62.927	ENSMALG00000016025	-	98	61.244	Monopterus_albus
ENSG00000136960	ENPP2	100	94.779	MGP_CAROLIEiJ_G0019793	Enpp2	100	94.206	Mus_caroli
ENSG00000136960	ENPP2	100	94.578	ENSMUSG00000022425	Enpp2	100	94.098	Mus_musculus
ENSG00000136960	ENPP2	100	94.578	MGP_PahariEiJ_G0019803	Enpp2	100	93.989	Mus_pahari
ENSG00000136960	ENPP2	100	94.578	MGP_SPRETEiJ_G0020690	Enpp2	100	94.098	Mus_spretus
ENSG00000136960	ENPP2	100	92.872	ENSMPUG00000001034	ENPP2	100	92.872	Mustela_putorius_furo
ENSG00000136960	ENPP2	100	93.378	ENSMLUG00000006285	ENPP2	100	93.378	Myotis_lucifugus
ENSG00000136960	ENPP2	100	95.219	ENSNGAG00000021370	Enpp2	99	95.327	Nannospalax_galili
ENSG00000136960	ENPP2	94	58.228	ENSNBRG00000012061	enpp2	92	60.392	Neolamprologus_brichardi
ENSG00000136960	ENPP2	99	53.924	ENSNBRG00000023272	-	99	53.924	Neolamprologus_brichardi
ENSG00000136960	ENPP2	99	98.125	ENSNLEG00000004918	ENPP2	100	96.847	Nomascus_leucogenys
ENSG00000136960	ENPP2	100	93.227	ENSODEG00000001689	ENPP2	100	90.710	Octodon_degus
ENSG00000136960	ENPP2	95	61.137	ENSONIG00000007198	-	99	61.137	Oreochromis_niloticus
ENSG00000136960	ENPP2	100	68.400	ENSONIG00000007998	enpp2	100	67.723	Oreochromis_niloticus
ENSG00000136960	ENPP2	100	96.215	ENSOCUG00000013534	ENPP2	99	95.897	Oryctolagus_cuniculus
ENSG00000136960	ENPP2	99	59.887	ENSORLG00000000802	-	99	62.169	Oryzias_latipes
ENSG00000136960	ENPP2	99	59.774	ENSORLG00020013706	-	99	61.882	Oryzias_latipes_hni
ENSG00000136960	ENPP2	99	59.774	ENSORLG00015006774	-	99	60.698	Oryzias_latipes_hsok
ENSG00000136960	ENPP2	97	60.885	ENSOMEG00000012494	-	97	61.871	Oryzias_melastigma
ENSG00000136960	ENPP2	100	94.613	ENSOGAG00000007652	ENPP2	100	94.613	Otolemur_garnettii
ENSG00000136960	ENPP2	100	93.348	ENSOARG00000015457	ENPP2	100	93.348	Ovis_aries
ENSG00000136960	ENPP2	100	99.563	ENSPPAG00000031694	ENPP2	100	99.563	Pan_paniscus
ENSG00000136960	ENPP2	100	96.833	ENSPPRG00000024856	ENPP2	100	96.833	Panthera_pardus
ENSG00000136960	ENPP2	100	96.813	ENSPTIG00000015615	ENPP2	100	94.149	Panthera_tigris_altaica
ENSG00000136960	ENPP2	100	99.344	ENSPTRG00000020534	ENPP2	100	99.344	Pan_troglodytes
ENSG00000136960	ENPP2	100	99.126	ENSPANG00000016168	ENPP2	100	99.126	Papio_anubis
ENSG00000136960	ENPP2	100	71.486	ENSPKIG00000019314	enpp2	99	70.574	Paramormyrops_kingsleyae
ENSG00000136960	ENPP2	99	64.925	ENSPKIG00000024612	-	99	64.925	Paramormyrops_kingsleyae
ENSG00000136960	ENPP2	100	83.815	ENSPSIG00000015853	ENPP2	100	83.815	Pelodiscus_sinensis
ENSG00000136960	ENPP2	100	65.243	ENSPMGG00000011519	enpp2	97	67.836	Periophthalmus_magnuspinnatus
ENSG00000136960	ENPP2	100	93.825	ENSPEMG00000009296	Enpp2	100	91.257	Peromyscus_maniculatus_bairdii
ENSG00000136960	ENPP2	92	89.098	ENSPCIG00000011446	ENPP2	99	89.098	Phascolarctos_cinereus
ENSG00000136960	ENPP2	99	60.773	ENSPFOG00000002408	-	99	60.773	Poecilia_formosa
ENSG00000136960	ENPP2	100	66.925	ENSPFOG00000006857	enpp2	99	66.974	Poecilia_formosa
ENSG00000136960	ENPP2	100	67.331	ENSPLAG00000019375	enpp2	99	67.453	Poecilia_latipinna
ENSG00000136960	ENPP2	94	62.822	ENSPMEG00000020346	-	95	62.822	Poecilia_mexicana
ENSG00000136960	ENPP2	100	69.200	ENSPMEG00000023334	enpp2	100	68.033	Poecilia_mexicana
ENSG00000136960	ENPP2	99	60.422	ENSPREG00000021543	-	99	60.422	Poecilia_reticulata
ENSG00000136960	ENPP2	100	66.928	ENSPREG00000010633	enpp2	98	67.150	Poecilia_reticulata
ENSG00000136960	ENPP2	100	98.982	ENSPPYG00000018842	ENPP2	100	98.982	Pongo_abelii
ENSG00000136960	ENPP2	100	97.451	ENSPCOG00000015061	ENPP2	100	97.451	Propithecus_coquereli
ENSG00000136960	ENPP2	100	89.399	ENSPVAG00000003713	ENPP2	100	89.399	Pteropus_vampyrus
ENSG00000136960	ENPP2	99	60.514	ENSPNYG00000023702	-	99	60.514	Pundamilia_nyererei
ENSG00000136960	ENPP2	100	67.000	ENSPNYG00000014687	enpp2	99	66.825	Pundamilia_nyererei
ENSG00000136960	ENPP2	99	61.260	ENSPNAG00000002597	-	99	61.260	Pygocentrus_nattereri
ENSG00000136960	ENPP2	100	69.277	ENSPNAG00000001739	enpp2	98	68.921	Pygocentrus_nattereri
ENSG00000136960	ENPP2	99	88.750	ENSRNOG00000004089	Enpp2	100	84.820	Rattus_norvegicus
ENSG00000136960	ENPP2	100	98.907	ENSRBIG00000042701	ENPP2	100	98.907	Rhinopithecus_bieti
ENSG00000136960	ENPP2	100	98.874	ENSRROG00000025107	ENPP2	100	98.874	Rhinopithecus_roxellana
ENSG00000136960	ENPP2	100	96.719	ENSSBOG00000014187	ENPP2	100	96.719	Saimiri_boliviensis_boliviensis
ENSG00000136960	ENPP2	100	87.937	ENSSHAG00000017449	ENPP2	100	87.937	Sarcophilus_harrisii
ENSG00000136960	ENPP2	100	66.931	ENSSFOG00015000561	-	97	70.273	Scleropages_formosus
ENSG00000136960	ENPP2	100	72.289	ENSSFOG00015004691	enpp2	97	71.581	Scleropages_formosus
ENSG00000136960	ENPP2	98	61.967	ENSSMAG00000013835	-	98	61.967	Scophthalmus_maximus
ENSG00000136960	ENPP2	95	60.949	ENSSDUG00000012801	-	97	60.949	Seriola_dumerili
ENSG00000136960	ENPP2	100	69.400	ENSSDUG00000010456	ENPP2	100	68.800	Seriola_dumerili
ENSG00000136960	ENPP2	100	68.800	ENSSLDG00000022146	enpp2	98	71.149	Seriola_lalandi_dorsalis
ENSG00000136960	ENPP2	98	60.560	ENSSLDG00000019717	-	99	60.560	Seriola_lalandi_dorsalis
ENSG00000136960	ENPP2	100	80.765	ENSSPUG00000008607	ENPP2	100	80.765	Sphenodon_punctatus
ENSG00000136960	ENPP2	98	62.367	ENSSPAG00000022548	-	93	75.877	Stegastes_partitus
ENSG00000136960	ENPP2	100	69.800	ENSSPAG00000019787	enpp2	99	69.240	Stegastes_partitus
ENSG00000136960	ENPP2	100	96.267	ENSSSCG00000006001	ENPP2	100	96.066	Sus_scrofa
ENSG00000136960	ENPP2	100	83.734	ENSTGUG00000012352	-	100	83.734	Taeniopygia_guttata
ENSG00000136960	ENPP2	100	68.526	ENSTRUG00000013770	enpp2	100	69.259	Takifugu_rubripes
ENSG00000136960	ENPP2	94	58.072	ENSTRUG00000010731	-	95	58.072	Takifugu_rubripes
ENSG00000136960	ENPP2	93	60.732	ENSTNIG00000005380	-	99	60.732	Tetraodon_nigroviridis
ENSG00000136960	ENPP2	100	95.418	ENSTTRG00000013931	ENPP2	99	95.504	Tursiops_truncatus
ENSG00000136960	ENPP2	81	95.545	ENSUAMG00000009318	-	84	95.545	Ursus_americanus
ENSG00000136960	ENPP2	100	95.410	ENSUMAG00000020711	ENPP2	100	95.410	Ursus_maritimus
ENSG00000136960	ENPP2	100	92.022	ENSVPAG00000000765	ENPP2	100	92.022	Vicugna_pacos
ENSG00000136960	ENPP2	100	95.847	ENSVVUG00000015843	ENPP2	100	95.847	Vulpes_vulpes
ENSG00000136960	ENPP2	100	75.435	ENSXETG00000003134	enpp2	100	75.435	Xenopus_tropicalis
ENSG00000136960	ENPP2	99	56.800	ENSXCOG00000019203	-	98	54.446	Xiphophorus_couchianus
ENSG00000136960	ENPP2	100	66.267	ENSXMAG00000022227	enpp2	99	64.336	Xiphophorus_maculatus
ENSG00000136960	ENPP2	100	63.900	ENSXMAG00000020942	enpp2	99	62.202	Xiphophorus_maculatus
ENSG00000136960	ENPP2	94	62.331	ENSXMAG00000001408	-	88	62.331	Xiphophorus_maculatus
ENSG00000136960	ENPP2	100	64.930	ENSXMAG00000024423	enpp2	99	64.935	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003676	nucleic acid binding	-	IEA	Function
GO:0004528	phosphodiesterase I activity	21873635.	IBA	Function
GO:0004551	nucleotide diphosphatase activity	-	IEA	Function
GO:0004622	lysophospholipase activity	21873635.	IBA	Function
GO:0004622	lysophospholipase activity	15280042.21240271.26371182.	IDA	Function
GO:0005044	scavenger receptor activity	-	IEA	Function
GO:0005509	calcium ion binding	21873635.	IBA	Function
GO:0005509	calcium ion binding	26371182.	IDA	Function
GO:0005509	calcium ion binding	-	ISS	Function
GO:0005615	extracellular space	21873635.	IBA	Component
GO:0005615	extracellular space	15280042.26371182.	IDA	Component
GO:0005615	extracellular space	-	ISS	Component
GO:0005886	plasma membrane	8579579.	TAS	Component
GO:0006898	receptor-mediated endocytosis	-	IEA	Process
GO:0006935	chemotaxis	7982964.	NAS	Process
GO:0006955	immune response	-	IEA	Process
GO:0008134	transcription factor binding	8586446.	TAS	Function
GO:0008270	zinc ion binding	21873635.	IBA	Function
GO:0008270	zinc ion binding	26371182.	IDA	Function
GO:0008270	zinc ion binding	-	ISS	Function
GO:0009395	phospholipid catabolic process	15280042.26371182.	IDA	Process
GO:0010634	positive regulation of epithelial cell migration	18054784.	IGI	Process
GO:0010634	positive regulation of epithelial cell migration	18054784.	IMP	Process
GO:0016787	hydrolase activity	7982964.	TAS	Function
GO:0030247	polysaccharide binding	-	IEA	Function
GO:0030334	regulation of cell migration	1733949.	IDA	Process
GO:0034638	phosphatidylcholine catabolic process	21873635.	IBA	Process
GO:0034638	phosphatidylcholine catabolic process	21240271.	IDA	Process
GO:0045765	regulation of angiogenesis	-	IEA	Process
GO:0047391	alkylglycerophosphoethanolamine phosphodiesterase activity	21873635.	IBA	Function
GO:0048870	cell motility	1733949.	TAS	Process
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	18054784.	IDA	Process
GO:0090305	nucleic acid phosphodiester bond hydrolysis	-	IEA	Process
GO:2000394	positive regulation of lamellipodium morphogenesis	18054784.	IGI	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

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Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.