EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25514464	A novel antisense long noncoding RNA regulates the expression of MDC1 in bladder cancer.	Oncotarget	2015 Jan 1	Xue Y	-
25934801	MDC1 functionally identified as an androgen receptor co-activator participates in suppression of prostate cancer.	Nucleic Acids Res	2015 May 26	Wang C	doi: 10.1093/nar/gkv394
26247734	Silencing NFBD1/MDC1 enhances the radiosensitivity of human nasopharyngeal cancer CNE1 cells and results in tumor growth inhibition.	Cell Death Dis	2015 Aug 6	Wang Z	doi: 10.1038/cddis.2015.214.
18635967	Differential regulation of centrosome integrity by DNA damage response proteins.	Cell Cycle	2008 Jul 15	Rai R	-
12551934	NFBD1, like 53BP1, is an early and redundant transducer mediating Chk2 phosphorylation in response to DNA damage.	J Biol Chem	2003 Mar 14	Peng A	-
21853275	NFBD1/MDC1 is a protein of oncogenic potential in human cervical cancer.	Mol Cell Biochem	2012 Jan	Yuan C	doi: 10.1007/s11010-011-1027-7
20364298	Growth inhibition, morphology change, and cell cycle alterations in NFBD1-depleted human esophageal cancer cells.	Mol Cell Biochem	2010 Sep	Yang Z	doi: 10.1007/s11010-010-0460-3
25198518	A Newfound association between MDC1 functional polymorphism and lung cancer risk in Chinese.	PLoS One	2014 Sep 8	Wang B	doi: 10.1371/journal.pone.0106794
20521098	Mediator of DNA damage checkpoint protein 1 (MDC1) expression as a prognostic marker for nodal recurrence in early-stage breast cancer patients treated with breast-conserving surgery and radiation therapy.	Breast Cancer Res Treat	2011 Apr	Patel AN	doi: 10.1007/s10549-010-0960-6
25592380	MDC1 promotes ovarian cancer metastasis by inducing epithelial-mesenchymal transition.	Tumour Biol	2015 Jun	Liu X	doi: 10.1007/s13277-015-3063-5
29545602	LRH1 enhances cell resistance to chemotherapy by transcriptionally activating MDC1 expression and attenuating DNA damage in human breast cancer.	Oncogene	2018 Jun	Wang S	doi: 10.1038/s41388-018-0193-4

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr6	30703141	Missense_Mutation	rs148600920	R1943Q	0.09
BLCA	chr6	30712906	Missense_Mutation	novel	P346S	0.3
BLCA	chr6	30705910	Silent	NA	E1091E	0.12
BLCA	chr6	30712910	Silent	NA	V344V	0.12
BLCA	chr6	30715172	Missense_Mutation	rs758314552	E2K	0.49
BLCA	chr6	30702754	Missense_Mutation	NA	E1997K	0.07
BLCA	chr6	30708236	Silent	novel	P781P	0.06
BLCA	chr6	30713971	Missense_Mutation	novel	D117N	0.23
BLCA	chr6	30707738	Silent	NA	Q947Q	0.17
BLCA	chr6	30700340	3'UTR	novel		0.52
BLCA	chr6	30706056	Missense_Mutation	NA	P1043S	0.58
BLCA	chr6	30708255	Missense_Mutation	novel	Y775C	0.09
BLCA	chr6	30707956	Missense_Mutation	novel	D875H	0.19
BLCA	chr6	30713294	Missense_Mutation	novel	L216F	0.08
BLCA	chr6	30704188	Frame_Shift_Del	novel	*T1666Qfs10**	0.22
BLCA	chr6	30707693	Silent	novel	A962A	0.17
BLCA	chr6	30703867	Silent	novel	E1772E	0.37
BLCA	chr6	30713987	Silent	NA	V111V	0.19
BLCA	chr6	30703527	Frame_Shift_Ins	novel	*T1858Nfs30**	0.58
BLCA	chr6	30704369	Missense_Mutation	NA	S1605C	0.5
BLCA	chr6	30706071	Missense_Mutation	NA	L1038V	0.53
BLCA	chr6	30707450	Silent	novel	L1006L	0.09
BLCA	chr6	30704810	Missense_Mutation	NA	S1458C	0.22
BLCA	chr6	30704777	Missense_Mutation	NA	P1469H	0.45
BLCA	chr6	30706096	Splice_Region	rs149848514	G1029G	0.46
BRCA	chr6	30704005	Silent	rs746237964	A1726A	0.04
BRCA	chr6	30705507	Missense_Mutation	NA	Q1226E	0.04
BRCA	chr6	30705898	Silent	NA	S1095S	0.26
BRCA	chr6	30703925	Nonsense_Mutation	NA	S1753*	0.12
BRCA	chr6	30711945	Missense_Mutation	novel	A666V	0.08
BRCA	chr6	30711948	Missense_Mutation	NA	G665E	0.54
BRCA	chr6	30704205	Missense_Mutation	NA	L1660F	0.56
BRCA	chr6	30705396	Missense_Mutation	NA	E1263Q	0.4
BRCA	chr6	30704778	Missense_Mutation	NA	P1469S	0.14
CESC	chr6	30712978	Nonsense_Mutation	novel	Q322*	0.24
CESC	chr6	30700412	3'UTR	novel		0.6
CESC	chr6	30713915	Silent	NA	V135V	0.32
CESC	chr6	30713158	Nonsense_Mutation	NA	Q262*	0.39
CESC	chr6	30704400	Missense_Mutation	rs762832250	R1595W	0.17
CESC	chr6	30703659	Missense_Mutation	NA	E1842K	0.18
CESC	chr6	30708165	Missense_Mutation	rs745970640	R805K	0.5
CESC	chr6	30712813	Missense_Mutation	novel	D377H	0.58
CESC	chr6	30713706	Missense_Mutation	novel	E177K	0.36
CESC	chr6	30712662	Nonsense_Mutation	NA	W427*	0.47
CESC	chr6	30703464	Missense_Mutation	rs763451532	R1879H	0.37
CESC	chr6	30708266	Silent	novel	H771H	0.34
CESC	chr6	30712997	Silent	novel	E315E	0.34
CESC	chr6	30712198	Missense_Mutation	novel	E582Q	0.17
CESC	chr6	30712729	Missense_Mutation	novel	D405Y	0.42
CESC	chr6	30713913	Missense_Mutation	NA	S136C	0.14
CESC	chr6	30704210	Missense_Mutation	novel	S1658F	0.44
CESC	chr6	30707637	Missense_Mutation	NA	S981L	0.36
CESC	chr6	30713238	Nonsense_Mutation	novel	S235*	0.41
CESC	chr6	30704832	Missense_Mutation	NA	T1451A	0.25
CESC	chr6	30705384	Missense_Mutation	NA	Q1267E	0.11
COAD	chr6	30713686	Frame_Shift_Del	novel	*K183Nfs9**	0.26
COAD	chr6	30700336	3'UTR	novel		0.35
COAD	chr6	30703532	Silent	rs745466962	V1856V	0.27
COAD	chr6	30705534	Nonsense_Mutation	NA	R1217*	0.44
COAD	chr6	30712084	Missense_Mutation	NA	A620T	0.29
COAD	chr6	30712031	Silent	NA	D637D	0.36
COAD	chr6	30705070	Silent	NA	P1371P	0.15
COAD	chr6	30705153	Missense_Mutation	NA	P1344T	0.3
COAD	chr6	30705274	Frame_Shift_Del	NA	*K1304Sfs57**	0.38
COAD	chr6	30713685	Frame_Shift_Ins	NA	*S184Ifs14**	0.32
COAD	chr6	30704906	Missense_Mutation	NA	P1426H	0.3
COAD	chr6	30712764	Missense_Mutation	novel	K393R	0.06
COAD	chr6	30704621	Missense_Mutation	rs753841715	R1521Q	0.42
COAD	chr6	30707456	Splice_Site	novel	X1005_splice	0.04
COAD	chr6	30713976	Missense_Mutation	NA	L115P	0.07
COAD	chr6	30705015	Missense_Mutation	rs144566920	R1390W	0.1
COAD	chr6	30712026	Missense_Mutation	NA	P639L	0.22
COAD	chr6	30705895	Silent	NA	S1096S	0.21
COAD	chr6	30703986	Missense_Mutation	rs747463459	L1733F	0.33
COAD	chr6	30708140	Silent	NA	V813V	0.36
COAD	chr6	30703472	Missense_Mutation	rs2239885	I1876M	0.2
COAD	chr6	30708001	Nonsense_Mutation	NA	E860*	0.2
COAD	chr6	30704044	Silent	NA	E1713E	0.4
COAD	chr6	30711718	Missense_Mutation	NA	D693Y	0.37
ESCA	chr6	30705893	In_Frame_Del	novel	S1096_E1097del	0.18
ESCA	chr6	30708220	Missense_Mutation	rs148637924	G787R	0.5
ESCA	chr6	30703810	Silent	rs557483176	V1791V	0.35
ESCA	chr6	30712254	Missense_Mutation	novel	L563H	0.59
ESCA	chr6	30704485	Missense_Mutation	novel	K1566N	0.38
ESCA	chr6	30712071	Missense_Mutation	rs746258696	G624A	0.35
ESCA	chr6	30712765	Missense_Mutation	novel	K393E	0.09
ESCA	chr6	30712278	Missense_Mutation	novel	A555V	0.2
GBM	chr6	30712324	Missense_Mutation	novel	K540Q	0.09
GBM	chr6	30703747	Missense_Mutation	NA	K1812N	0.46
GBM	chr6	30705612	Nonsense_Mutation	novel	K1191*	0.06
GBM	chr6	30713151	Nonsense_Mutation	novel	L264*	0.09
GBM	chr6	30704374	Silent	novel	R1603R	0.12
GBM	chr6	30712048	Missense_Mutation	novel	A632P	0.08
GBM	chr6	30703980	Missense_Mutation	novel	A1735T	0.28
GBM	chr6	30708203	Missense_Mutation	novel	E792D	0.57
GBM	chr6	30712878	Missense_Mutation	novel	G355E	0.22
GBM	chr6	30706096	Splice_Region	rs149848514	G1029G	0.39
GBM	chr6	30712303	Missense_Mutation	novel	G547R	0.05
GBM	chr6	30715094	Missense_Mutation	rs763377150	V28M	0.19
GBM	chr6	30707944	Missense_Mutation	NA	E879Q	0.29
GBM	chr6	30712724	Silent	rs764506177	D406D	0.09
HNSC	chr6	30704542	Silent	novel	V1547V	0.19
HNSC	chr6	30705425	Missense_Mutation	novel	S1253Y	0.19
HNSC	chr6	30713956	Missense_Mutation	novel	L122F	0.72
HNSC	chr6	30714053	Silent	NA	L89L	0.79
HNSC	chr6	30703650	Missense_Mutation	rs780332704	D1845N	0.28
HNSC	chr6	30706042	Silent	novel	A1047A	0.43
HNSC	chr6	30712882	Missense_Mutation	novel	H354Y	0.14
HNSC	chr6	30707795	Silent	rs773539522	C928C	0.24
HNSC	chr6	30705660	Missense_Mutation	novel	D1175Y	0.31
HNSC	chr6	30703955	Missense_Mutation	novel	S1743C	0.22
HNSC	chr6	30703885	Silent	novel	S1766S	0.58
HNSC	chr6	30712567	Missense_Mutation	rs777255794	E459K	0.22
HNSC	chr6	30713919	Missense_Mutation	novel	D134V	0.25
HNSC	chr6	30704864	Missense_Mutation	novel	S1440F	0.05
HNSC	chr6	30704993	Missense_Mutation	novel	N1397I	0.28
HNSC	chr6	30713979	Missense_Mutation	rs61748587	R114H	0.29
HNSC	chr6	30706017	Nonsense_Mutation	novel	Q1056*	0.16
HNSC	chr6	30700593	Missense_Mutation	novel	H2048N	0.07
KICH	chr6	30704367	Missense_Mutation	novel	V1606F	0.61
KIRC	chr6	30712373	Silent	NA	T523T	0.24
KIRC	chr6	30713712	Missense_Mutation	novel	L175V	0.29
KIRP	chr6	30713057	Silent	novel	P295P	0.45
KIRP	chr6	30712216	Missense_Mutation	NA	D576N	0.21
KIRP	chr6	30713236	Missense_Mutation	NA	A236S	0.06
KIRP	chr6	30713897	Silent	novel	S141S	0.43
LAML	chr6	30712175	Silent	novel	A589A	0.08
LAML	chr6	30707788	Missense_Mutation	novel	A931T	0.05
LAML	chr6	30704189	Missense_Mutation	novel	P1665L	0.04
LAML	chr6	30713920	Frame_Shift_Del	novel	*D134Mfs12**	0.12
LGG	chr6	30705989	Missense_Mutation	novel	P1065L	0.43
LGG	chr6	30704744	Missense_Mutation	novel	R1480I	0.08
LGG	chr6	30707711	Missense_Mutation	novel	Q956H	0.07
LGG	chr6	30712104	Missense_Mutation	novel	A613V	0.16
LGG	chr6	30712397	Silent	novel	A515A	0.42
LGG	chr6	30712889	Missense_Mutation	novel	K351N	0.39
LGG	chr6	30700540	Silent	novel	L2065L	0.36
LGG	chr6	30711671	Silent	NA	L708L	0.05
LIHC	chr6	30700227	3'UTR	novel		0.24
LIHC	chr6	30700503	Frame_Shift_Ins	novel	*A2078Rfs59**	0.06
LIHC	chr6	30700543	Silent	novel	F2064F	0.27
LIHC	chr6	30705637	Silent	NA	P1182P	0.32
LIHC	chr6	30703909	Missense_Mutation	NA	W1758C	0.37
LIHC	chr6	30704797	Missense_Mutation	NA	D1462E	0.34
LIHC	chr6	30712269	Frame_Shift_Del	novel	*G558Dfs10**	0.23
LIHC	chr6	30711454	Missense_Mutation	NA	P727S	0.37
LUAD	chr6	30705602	Missense_Mutation	NA	S1194C	0.21
LUAD	chr6	30707770	Missense_Mutation	NA	V937L	0.29
LUAD	chr6	30708161	Silent	novel	G806G	0.08
LUAD	chr6	30703537	Missense_Mutation	novel	D1855Y	0.05
LUAD	chr6	30704427	Nonsense_Mutation	NA	Q1586*	0.31
LUAD	chr6	30703501	Missense_Mutation	novel	D1867N	0.05
LUAD	chr6	30707799	Missense_Mutation	novel	E927V	0.1
LUAD	chr6	30715072	Missense_Mutation	rs372848423	H35R	0.2
LUAD	chr6	30704894	Missense_Mutation	rs755458710	S1430C	0.09
LUAD	chr6	30711874	Missense_Mutation	novel	D690H	0.08
LUAD	chr6	30705828	Missense_Mutation	novel	P1119T	0.05
LUAD	chr6	30707604	Missense_Mutation	novel	G992V	0.19
LUAD	chr6	30704583	Missense_Mutation	NA	A1534S	0.18
LUAD	chr6	30708358	Splice_Site	NA	X741_splice	0.59
LUAD	chr6	30708011	Missense_Mutation	NA	K856N	0.28
LUAD	chr6	30708163	Missense_Mutation	NA	G806W	0.31
LUAD	chr6	30706017	Missense_Mutation	novel	Q1056E	0.22
LUAD	chr6	30713975	Silent	novel	L115L	0.28
LUAD	chr6	30704154	Missense_Mutation	novel	Q1677E	0.07
LUAD	chr6	30708168	Missense_Mutation	NA	G804V	0.25
LUAD	chr6	30703231	Missense_Mutation	novel	G1913V	0.48
LUAD	chr6	30704977	Silent	NA	K1402K	0.23
LUAD	chr6	30711426	Missense_Mutation	NA	S736I	0.23
LUAD	chr6	30712339	Missense_Mutation	NA	I535V	0.13
LUSC	chr6	30704919	Nonsense_Mutation	novel	Q1422*	0.33
LUSC	chr6	30704525	Missense_Mutation	NA	S1553F	0.16
LUSC	chr6	30703959	Missense_Mutation	novel	C1742R	0.29
LUSC	chr6	30712227	Missense_Mutation	rs749854538	P572L	0.27
LUSC	chr6	30703900	Silent	NA	V1761V	0.05
LUSC	chr6	30704088	Missense_Mutation	novel	E1699Q	0.19
LUSC	chr6	30703449	Missense_Mutation	novel	T1884S	0.05
LUSC	chr6	30704785	Silent	NA	T1466T	0.27
LUSC	chr6	30704810	Missense_Mutation	NA	S1458Y	0.09
LUSC	chr6	30705772	Silent	NA	V1137V	0.11
LUSC	chr6	30704936	Missense_Mutation	NA	P1416L	0.84
LUSC	chr6	30705088	Silent	NA	S1365S	0.31
LUSC	chr6	30712249	Frame_Shift_Del	novel	*V565Yfs3**	0.11
LUSC	chr6	30705245	Missense_Mutation	novel	R1313K	0.22
LUSC	chr6	30703982	Missense_Mutation	NA	A1734V	0.19
LUSC	chr6	30703184	Missense_Mutation	novel	D1929N	0.42
LUSC	chr6	30707394	Missense_Mutation	novel	K1025M	0.2
LUSC	chr6	30700594	Silent	NA	P2047P	0.06
MESO	chr6	30704331	Nonsense_Mutation	novel	E1618*	0.2
OV	chr6	30700603	Missense_Mutation	novel	Q2044H	0.06
OV	chr6	30712855	Missense_Mutation	NA	A363P	0.27
OV	chr6	30714179	Missense_Mutation	novel	F47L	0.04
OV	chr6	30704219	Missense_Mutation	NA	P1655R	0.43
OV	chr6	30712544	Missense_Mutation	novel	N466K	0.11
OV	chr6	30712585	Missense_Mutation	novel	S453G	0.05
OV	chr6	30712788	Missense_Mutation	novel	A385V	0.05
PAAD	chr6	30700432	3'UTR	novel		0.16
PCPG	chr6	30704581	Silent	novel	A1534A	0.15
PCPG	chr6	30712234	Missense_Mutation	novel	A570T	0.09
PRAD	chr6	30703141	Missense_Mutation	rs148600920	R1943Q	0.08
PRAD	chr6	30705987	Frame_Shift_Del	novel	*L1066Ffs50**	0.25
PRAD	chr6	30712507	Missense_Mutation	novel	A479T	0.38
PRAD	chr6	30713040	Missense_Mutation	novel	T301I	0.32
READ	chr6	30708270	Missense_Mutation	rs529970009	T770M	0.43
READ	chr6	30703270	Missense_Mutation	NA	V1900A	0.27
READ	chr6	30703730	Missense_Mutation	NA	M1818T	0.24
READ	chr6	30700432	3'UTR	rs767500271		0.49
READ	chr6	30704940	Missense_Mutation	rs200570441	E1415K	0.41
READ	chr6	30704999	Missense_Mutation	NA	R1395I	0.15
SARC	chr6	30703769	Missense_Mutation	novel	P1805H	0.12
SKCM	chr6	30714019	Silent	NA	L101L	0.34
SKCM	chr6	30712928	Silent	novel	I338I	0.42
SKCM	chr6	30712567	Missense_Mutation	rs777255794	E459K	0.27
SKCM	chr6	30704122	Frame_Shift_Del	novel	*R1685Nfs12**	0.34
SKCM	chr6	30705072	Missense_Mutation	NA	P1371S	0.14
SKCM	chr6	30712531	Missense_Mutation	novel	L471F	0.26
SKCM	chr6	30704932	Silent	novel	S1417S	0.45
SKCM	chr6	30703215	Silent	NA	G1918G	0.24
SKCM	chr6	30711968	Silent	rs138559048	S658S	0.33
SKCM	chr6	30702826	Missense_Mutation	NA	P1973S	0.21
SKCM	chr6	30704807	Missense_Mutation	NA	T1459I	0.4
SKCM	chr6	30712961	Silent	rs757177695	I327I	0.1
SKCM	chr6	30713300	Silent	NA	F214F	0.13
SKCM	chr6	30713082	Missense_Mutation	NA	V287A	0.07
SKCM	chr6	30700571	Missense_Mutation	novel	V2055A	0.3
SKCM	chr6	30705803	Missense_Mutation	rs749393075	P1127L	0.38
SKCM	chr6	30702576	Missense_Mutation	rs754632799	P2027S	0.13
SKCM	chr6	30705953	Missense_Mutation	novel	T1077I	0.2
SKCM	chr6	30704910	Missense_Mutation	novel	T1425A	0.17
SKCM	chr6	30703833	Missense_Mutation	NA	H1784Y	0.17
SKCM	chr6	30703687	Silent	novel	V1832V	0.15
SKCM	chr6	30711716	Missense_Mutation	novel	D693E	0.06
SKCM	chr6	30712471	Missense_Mutation	NA	P491S	0.5
SKCM	chr6	30704809	Silent	NA	S1458S	0.19
SKCM	chr6	30704055	Missense_Mutation	NA	I1710F	0.44
SKCM	chr6	30705905	Missense_Mutation	rs372811207	P1093L	0.28
SKCM	chr6	30712751	Silent	novel	S397S	0.38
SKCM	chr6	30712752	Missense_Mutation	novel	S397F	0.36
SKCM	chr6	30704825	Missense_Mutation	NA	P1453L	0.48
SKCM	chr6	30708314	Silent	NA	F755F	0.24
SKCM	chr6	30707723	Silent	novel	E952E	0.11
SKCM	chr6	30704245	Silent	novel	S1646S	0.43
SKCM	chr6	30704246	Missense_Mutation	novel	S1646F	0.42
SKCM	chr6	30708296	Silent	NA	E761E	0.44
SKCM	chr6	30703724	Missense_Mutation	NA	S1820L	0.81
SKCM	chr6	30700578	Silent	NA	L2053L	0.06
SKCM	chr6	30705081	Missense_Mutation	NA	P1368S	0.07
SKCM	chr6	30703198	Missense_Mutation	NA	S1924F	0.26
SKCM	chr6	30713337	Missense_Mutation	NA	S202F	0.37
SKCM	chr6	30705768	Missense_Mutation	NA	P1139S	0.41
SKCM	chr6	30703788	Missense_Mutation	novel	F1799L	0.25
SKCM	chr6	30704051	Missense_Mutation	novel	S1711F	0.33
SKCM	chr6	30715115	Missense_Mutation	novel	S21R	0.17
SKCM	chr6	30715116	Silent	novel	S20S	0.17
SKCM	chr6	30712857	Missense_Mutation	NA	G362V	0.14
SKCM	chr6	30705898	Silent	NA	S1095S	0.33
SKCM	chr6	30713092	Missense_Mutation	novel	P284S	0.25
SKCM	chr6	30713654	Missense_Mutation	NA	P194L	0.58
SKCM	chr6	30711471	Missense_Mutation	novel	A721V	0.39
SKCM	chr6	30704076	Missense_Mutation	NA	P1703S	0.37
SKCM	chr6	30715062	Missense_Mutation	novel	S38R	0.21
SKCM	chr6	30715176	Splice_Region	novel		0.36
STAD	chr6	30712251	Missense_Mutation	novel	V564A	0.12
STAD	chr6	30712692	Missense_Mutation	rs771893736	A417V	0.48
STAD	chr6	30705200	Missense_Mutation	NA	T1328I	0.18
STAD	chr6	30714055	Missense_Mutation	NA	L89I	0.18
STAD	chr6	30703228	Frame_Shift_Del	novel	*G1914Efs57**	0.22
STAD	chr6	30705014	Missense_Mutation	rs747316218	R1390Q	0.3
STAD	chr6	30705894	Nonsense_Mutation	NA	E1097*	0.2
STAD	chr6	30712315	Missense_Mutation	rs751432651	V543M	0.28
STAD	chr6	30707662	Frame_Shift_Del	novel	*A973Rfs25**	0.42
STAD	chr6	30712827	Missense_Mutation	NA	S372T	0.35
STAD	chr6	30707393	In_Frame_Del	NA	K1025del	0.32
STAD	chr6	30705487	Missense_Mutation	NA	K1232N	0.37
STAD	chr6	30704252	Missense_Mutation	novel	R1644M	0.38
STAD	chr6	30705260	Missense_Mutation	rs201814179	R1308Q	0.38
STAD	chr6	30703731	Missense_Mutation	NA	M1818V	0.22
STAD	chr6	30704443	Silent	NA	P1580P	0.16
STAD	chr6	30704104	Silent	rs187724951	P1693P	0.2
STAD	chr6	30708006	Missense_Mutation	NA	D858G	0.38
STAD	chr6	30700265	3'UTR	novel		0.38
STAD	chr6	30703527	Missense_Mutation	NA	T1858I	0.24
STAD	chr6	30704645	Missense_Mutation	rs148973631	R1513Q	0.39
STAD	chr6	30708298	Missense_Mutation	novel	E761K	0.46
STAD	chr6	30702795	Missense_Mutation	NA	L1983P	0.08
STAD	chr6	30712993	Missense_Mutation	NA	H317Y	0.11
STAD	chr6	30702829	Missense_Mutation	NA	D1972N	0.06
STAD	chr6	30703171	Missense_Mutation	rs536243116	R1933Q	0.18
STAD	chr6	30713686	Frame_Shift_Del	novel	*K183Nfs9**	0.47
STAD	chr6	30706046	Missense_Mutation	novel	P1046L	0.4
STAD	chr6	30700447	3'UTR	rs772354979		0.3
STAD	chr6	30707427	Missense_Mutation	NA	A1014V	0.17
STAD	chr6	30712009	Missense_Mutation	NA	L645I	0.14
STAD	chr6	30713251	Missense_Mutation	NA	E231K	0.4
STAD	chr6	30703850	Missense_Mutation	NA	L1778R	0.36
STAD	chr6	30705769	Silent	NA	T1138T	0.25
STAD	chr6	30704645	Missense_Mutation	rs148973631	R1513Q	0.29
STAD	chr6	30705948	Missense_Mutation	rs78556678	R1079C	0.28
STAD	chr6	30704175	Missense_Mutation	rs200530869	V1670I	0.15
STAD	chr6	30712069	Frame_Shift_Del	novel	*A625Pfs31**	0.26
STAD	chr6	30713325	Missense_Mutation	novel	G206D	0.41
THCA	chr6	30703674	Frame_Shift_Del	novel	*V1837Dfs50**	0.38
UCEC	chr6	30705788	Missense_Mutation	novel	S1132C	0.16
UCEC	chr6	30704008	Missense_Mutation	novel	R1725S	0.16
UCEC	chr6	30707723	Missense_Mutation	novel	E952D	0.19
UCEC	chr6	30712258	Silent	novel	L562L	0.49
UCEC	chr6	30704676	Missense_Mutation	novel	D1503H	0.33
UCEC	chr6	30703639	Missense_Mutation	NA	E1848D	0.34
UCEC	chr6	30706079	Missense_Mutation	NA	D1035A	0.33
UCEC	chr6	30708281	Missense_Mutation	novel	Q766H	0.06
UCEC	chr6	30713188	Missense_Mutation	novel	V252I	0.34
UCEC	chr6	30704282	Missense_Mutation	rs770716446	T1634I	0.25
UCEC	chr6	30703913	Missense_Mutation	NA	R1757I	0.43
UCEC	chr6	30703704	Missense_Mutation	novel	P1827S	0.17
UCEC	chr6	30705491	Missense_Mutation	rs771197050	R1231I	0.37
UCEC	chr6	30705230	Missense_Mutation	novel	S1318F	0.31
UCEC	chr6	30706056	Missense_Mutation	NA	P1043S	0.41
UCEC	chr6	30705221	Missense_Mutation	rs747924943	T1321I	0.13
UCEC	chr6	30712969	Missense_Mutation	novel	G325C	0.39
UCEC	chr6	30705922	Missense_Mutation	novel	Q1087H	0.43
UCEC	chr6	30715045	Missense_Mutation	novel	E44A	0.48
UCEC	chr6	30704879	Missense_Mutation	novel	G1435D	0.23
UCEC	chr6	30704994	Missense_Mutation	NA	N1397H	0.45
UCEC	chr6	30703751	Missense_Mutation	rs368708770	R1811H	0.25
UCEC	chr6	30704744	Missense_Mutation	NA	R1480K	0.23
UCEC	chr6	30705772	Silent	NA	V1137V	0.23
UCEC	chr6	30707575	In_Frame_Ins	novel	S988_R1001dup	0.68
UCEC	chr6	30713203	Nonsense_Mutation	novel	Q247*	0.42
UCEC	chr6	30712229	Nonsense_Mutation	novel	W571*	0.17
UCEC	chr6	30704587	Silent	rs771369050	P1532P	0.38
UCEC	chr6	30704939	Missense_Mutation	novel	E1415G	0.07
UCEC	chr6	30705562	Silent	novel	L1207L	0.32
UCEC	chr6	30713819	Nonsense_Mutation	novel	S168*	0.08
UCEC	chr6	30708071	Missense_Mutation	novel	E836D	0.41
UCEC	chr6	30708124	Nonsense_Mutation	novel	E819*	0.4
UCEC	chr6	30707688	Missense_Mutation	novel	S964N	0.29
UCEC	chr6	30714060	Missense_Mutation	novel	P87H	0.43
UCEC	chr6	30713038	Missense_Mutation	novel	D302Y	0.25
UCEC	chr6	30705618	Nonsense_Mutation	novel	G1189*	0.37
UCEC	chr6	30706095	Missense_Mutation	rs771933981	D1030N	0.35
UCEC	chr6	30705125	Missense_Mutation	rs768639435	S1353N	0.41
UCEC	chr6	30705523	Silent	novel	T1220T	0.39
UCEC	chr6	30712612	Nonsense_Mutation	novel	R444*	0.11
UCEC	chr6	30712821	Missense_Mutation	novel	A374V	0.36
UCEC	chr6	30715128	Missense_Mutation	novel	E16D	0.35
UCEC	chr6	30705484	Frame_Shift_Ins	novel	*N1233Kfs2**	0.27
UCEC	chr6	30705755	Missense_Mutation	novel	S1143Y	0.12
UCEC	chr6	30707661	Missense_Mutation	rs780670990	A973V	0.37
UCEC	chr6	30712968	Missense_Mutation	novel	G325D	0.58
UCEC	chr6	30713235	Missense_Mutation	NA	A236V	0.53
UCEC	chr6	30704044	Silent	NA	E1713E	0.14
UCEC	chr6	30708001	Nonsense_Mutation	NA	E860*	0.22
UCEC	chr6	30703174	Missense_Mutation	rs761516200	R1932H	0.24
UCEC	chr6	30704586	Missense_Mutation	rs372525319	A1533T	0.39
UCEC	chr6	30708064	Silent	novel	L839L	0.42
UCEC	chr6	30700553	Missense_Mutation	rs773327966	S2061L	0.66
UCEC	chr6	30708160	Missense_Mutation	NA	R807G	0.11
UCEC	chr6	30707404	Missense_Mutation	novel	A1022T	0.09
UCEC	chr6	30700271	3'UTR	novel		0.43
UCEC	chr6	30705017	Missense_Mutation	NA	S1389Y	0.38
UCEC	chr6	30707959	Missense_Mutation	novel	S874P	0.26
UCEC	chr6	30708296	Missense_Mutation	novel	E761D	0.42
UCEC	chr6	30712981	Missense_Mutation	novel	A321T	0.24
UCEC	chr6	30704630	Missense_Mutation	novel	R1518I	0.39
UCEC	chr6	30705326	Missense_Mutation	novel	P1286L	0.35
UCEC	chr6	30705991	Silent	rs576365258	P1064P	0.32
UCEC	chr6	30715112	Missense_Mutation	novel	E22K	0.42
UCEC	chr6	30704806	Silent	novel	T1459T	0.35
UCEC	chr6	30705152	Frame_Shift_Del	novel	*P1344Lfs17**	0.39
UCEC	chr6	30705686	Missense_Mutation	NA	P1166H	0.49
UCEC	chr6	30708273	Missense_Mutation	NA	D769G	0.24
UCEC	chr6	30713022	Missense_Mutation	novel	S307N	0.05
UCEC	chr6	30713806	Missense_Mutation	NA	V172I	0.18
UCEC	chr6	30700393	3'UTR	novel		0.11
UCEC	chr6	30700589	Missense_Mutation	novel	C2049Y	0.16
UCEC	chr6	30705191	Missense_Mutation	novel	E1331A	0.09
UCEC	chr6	30705860	Missense_Mutation	NA	R1108I	0.25
UCEC	chr6	30704773	Silent	rs547516755	T1470T	0.39
UCEC	chr6	30712171	Missense_Mutation	novel	V591L	0.26
UCEC	chr6	30712489	Missense_Mutation	novel	S485P	0.2
UCEC	chr6	30712885	Missense_Mutation	novel	F353L	0.2
UCEC	chr6	30706023	Missense_Mutation	NA	N1054D	0.38
UCEC	chr6	30700433	3'UTR	rs773278323		0.36
UCEC	chr6	30705143	Missense_Mutation	novel	T1347I	0.38
UCEC	chr6	30707630	Silent	rs553159423	P983P	0.31
UCEC	chr6	30705017	Missense_Mutation	NA	S1389Y	0.48
UCEC	chr6	30704126	Missense_Mutation	rs758783364	S1686Y	0.25
UCEC	chr6	30705232	Silent	NA	S1317S	0.25
UCEC	chr6	30700317	3'UTR	novel		0.22
UCEC	chr6	30702829	Missense_Mutation	NA	D1972N	0.37
UCEC	chr6	30704006	Missense_Mutation	novel	A1726V	0.2
UCEC	chr6	30715094	Missense_Mutation	rs763377150	V28M	0.39
UCEC	chr6	30714080	Silent	novel	I80I	0.48
UCEC	chr6	30712842	Missense_Mutation	rs768028369	A367V	0.43
UCEC	chr6	30704415	Missense_Mutation	novel	P1590T	0.11
UCEC	chr6	30712739	Silent	NA	N401N	0.06
UCEC	chr6	30703957	Nonsense_Mutation	novel	C1742*	0.43
UCEC	chr6	30705494	Missense_Mutation	novel	G1230E	0.38
UCEC	chr6	30705854	Missense_Mutation	rs199905318	R1110Q	0.11
UCEC	chr6	30707629	Missense_Mutation	rs201740735	V984I	0.44
UCEC	chr6	30712754	Silent	novel	A396A	0.36
UCEC	chr6	30714178	Missense_Mutation	novel	P48S	0.19

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0028	Kaplan-Meier Survival Analysis
SARC	0.00044	Kaplan-Meier Survival Analysis
ACC	0.00018	Kaplan-Meier Survival Analysis
SKCM	0.00011	Kaplan-Meier Survival Analysis
ESCA	0.047	Kaplan-Meier Survival Analysis
PAAD	0.0029	Kaplan-Meier Survival Analysis
READ	0.0025	Kaplan-Meier Survival Analysis
KICH	0.0059	Kaplan-Meier Survival Analysis
UCEC	0.024	Kaplan-Meier Survival Analysis
LIHC	0.0023	Kaplan-Meier Survival Analysis
THCA	0.031	Kaplan-Meier Survival Analysis
UVM	0.0006	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000137337 (Gene tree)
Gene ID: 9656
Gene Symbol: MDC1
Alias: NFBD1|KIAA0170|Em:AB023051.5
Full Name: mediator of DNA damage checkpoint 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 18,160 bases
Position: chr6:30,699,807-30,717,966
Accession: 21163
RBP type: non-canonical RBP
Summary: The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
30668775	Tyrosine kinase c-Abl couples RNA polymerase II transcription to DNA double-strand breaks.	Nucleic Acids Res	2019 Apr 23	Burger K	doi: 10.1093/nar/gkz024.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000494654	MDC1-208	148	-	-	- (aa)	-	-
ENST00000417033	MDC1-203	916	-	ENSP00000408962	306 (aa)	-	H0Y6Z8
ENST00000613547	MDC1-209	830	-	ENSP00000483601	142 (aa)	-	A0A087X0R2
ENST00000376406	MDC1-201	7576	XM_005249492	ENSP00000365588	2089 (aa)	XP_005249549	Q14676
ENST00000489540	MDC1-206	1402	-	-	- (aa)	-	-
ENST00000416571	MDC1-202	582	-	ENSP00000400979	162 (aa)	-	A2AB05
ENST00000425072	MDC1-205	582	-	ENSP00000396989	126 (aa)	-	A2AB07
ENST00000492462	MDC1-207	819	-	-	- (aa)	-	-
ENST00000422266	MDC1-204	583	-	ENSP00000411310	113 (aa)	-	A2AB06

Gene Model

Click here to download ENSG00000137337's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000137337	Behcet Syndrome	3.61722547635187E-05	20622878
ENSG00000137337	Immunoglobulins	3E-6	23382691
ENSG00000137337	Immunoglobulins	8E-6	23382691
ENSG00000137337	Immunoglobulins	8E-6	23382691

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000137337	rs3094093	6	30711851	T	IgG glycosylation	23382691	[0.13-0.32] unit increase	0.2231	EFO_0005193
ENSG00000137337	rs3094093	6	30711851	T	IgG glycosylation	23382691	[0.14-0.33] unit increase	0.2336	EFO_0005193
ENSG00000137337	rs3094093	6	30711851	T	IgG glycosylation	23382691	[0.12-0.32] unit decrease	0.2214	EFO_0005193
ENSG00000137337	rs28986317	6	30704212	?	Tonsillectomy	28928442	[0.073-0.138] unit decrease	0.1053	EFO_0007924
ENSG00000137337	rs114566187	6	30703811	T	Macrophage Migration Inhibitory Factor levels	27989323	[0.083-0.185] SD units decrease	0.1337	EFO_0008221

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000137337's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	12607005.16186822.16377563.17525332.18001824.18001825.18583988.18678890.19234442.19804756.20159462.20224574.21293379.24240613.25064736.29656893.	IPI	Function
GO:0005634	nucleus	15604234.24217620.24550317.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005694	chromosome	-	ISS	Component
GO:0005925	focal adhesion	-	IDA	Component
GO:0006303	double-strand break repair via nonhomologous end joining	-	TAS	Process
GO:0008022	protein C-terminus binding	17577209.	IPI	Function
GO:0016604	nuclear body	-	IDA	Component
GO:0031573	intra-S DNA damage checkpoint	17577209.	TAS	Process
GO:0042802	identical protein binding	21293379.29656893.	IPI	Function
GO:0070975	FHA domain binding	20008512.	IPI	Function

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.