EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28748856	The Short Isoform of Nuclear Mitotic Apparatus Protein 1 Functions as a Putative Tumor Suppressor.	Chin Med J (Engl)	2017 Aug 5	Qin WS	doi: 10.4103/0366-6999.211535.
18331640	Comprehensive analysis of NuMA variation in breast cancer.	BMC Cancer	2008 Mar 10	Kilpivaara O	doi: 10.1186/1471-2407-8-71.
24976592	Factors influencing false-positive results for nuclear matrix protein 22.	Eur Urol	2014 Nov	Behrens T	doi: 10.1016/j.eururo.2014.06.014
15684076	Association of the NuMA region on chromosome 11q13 with breast cancer susceptibility.	Proc Natl Acad Sci U S A	2005 Feb 8	Kammerer S	-
25451259	Identification and characterization of novel NuMA isoforms.	Biochem Biophys Res Commun	2014 Nov 21	Wu J	doi: 10.1016/j.bbrc.2014.10.104

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr11	72007411	Silent	rs575875975	D1747D	0.96
BLCA	chr11	72015040	Missense_Mutation	NA	Q821H	0.11
BLCA	chr11	72006047	Missense_Mutation	novel	G1894R	0.26
BLCA	chr11	72003909	Missense_Mutation	novel	A2105V	0.31
BLCA	chr11	72013822	Missense_Mutation	novel	I1227M	0.07
BLCA	chr11	72008821	Nonsense_Mutation	NA	R1695*	0.17
BLCA	chr11	72017806	Silent	NA	L334L	0.38
BLCA	chr11	72023121	Missense_Mutation	novel	E79Q	0.24
BLCA	chr11	72016132	Silent	rs752944008	F457F	0.51
BLCA	chr11	72023141	Missense_Mutation	novel	R72Q	0.4
BLCA	chr11	72015823	Silent	NA	L560L	0.16
BLCA	chr11	72004746	Missense_Mutation	rs754124730	R1967Q	0.33
BLCA	chr11	72015295	Silent	novel	I736I	0.5
BLCA	chr11	72015291	Missense_Mutation	novel	E738Q	0.36
BLCA	chr11	72013044	Missense_Mutation	novel	A1487T	0.32
BLCA	chr11	72015078	Missense_Mutation	novel	E809K	0.16
BLCA	chr11	72014677	Silent	NA	A942A	0.21
BLCA	chr11	72018941	Silent	novel	I208I	0.58
BLCA	chr11	72003450	3'UTR	novel		0.13
BLCA	chr11	72018506	Silent	novel	Q250Q	0.14
BLCA	chr11	72013472	Missense_Mutation	rs762061842	S1344F	0.09
BLCA	chr11	72018466	Silent	novel	L264L	0.17
BLCA	chr11	72015612	Missense_Mutation	rs746813048	R631W	0.21
BLCA	chr11	72035973	Splice_Region	rs758022093		0.84
BLCA	chr11	72006149	Silent	novel	L1860L	0.2
BRCA	chr11	72006226	Missense_Mutation	rs141331520	S1834L	0.18
BRCA	chr11	72015838	Missense_Mutation	NA	Q555H	0.36
BRCA	chr11	72015364	Silent	NA	V713V	0.37
BRCA	chr11	72013934	Missense_Mutation	rs375662470	R1190Q	0.17
BRCA	chr11	72018843	Missense_Mutation	rs763169605	R241H	0.38
BRCA	chr11	72013650	Missense_Mutation	rs778957434	E1285K	0.55
BRCA	chr11	72013551	Missense_Mutation	novel	Q1318E	0.14
BRCA	chr11	72014343	Missense_Mutation	novel	H1054Y	0.1
BRCA	chr11	72014053	Silent	NA	L1150L	0.5
BRCA	chr11	72018400	Missense_Mutation	novel	E286Q	0.13
BRCA	chr11	72015639	Nonsense_Mutation	NA	Q622*	0.19
BRCA	chr11	72015719	Missense_Mutation	rs371974605	S595F	0.46
BRCA	chr11	72016029	Missense_Mutation	NA	H492Y	0.4
BRCA	chr11	72014886	Missense_Mutation	rs1053601	E873K	0.29
BRCA	chr11	72014673	Frame_Shift_Del	novel	*E936Qfs45**	0.17
BRCA	chr11	72005244	Silent	NA	L1940L	0.57
BRCA	chr11	72016156	Silent	NA	K449K	0.41
BRCA	chr11	72003419	3'UTR	novel		0.47
CESC	chr11	72013943	Missense_Mutation	rs749408043	S1187L	0.47
CESC	chr11	72004768	Missense_Mutation	novel	D1960N	0.59
CESC	chr11	72007999	Intron	novel		0.5
CESC	chr11	72014732	Missense_Mutation	rs750257826	R924H	0.4
CESC	chr11	72008716	Missense_Mutation	NA	E1730K	0.39
CESC	chr11	72015029	Missense_Mutation	novel	A825V	0.21
CESC	chr11	72015450	Nonsense_Mutation	novel	Q685*	0.31
CESC	chr11	72013183	Silent	novel	L1440L	0.52
COAD	chr11	72013860	Missense_Mutation	novel	R1215W	0.33
COAD	chr11	72014966	Missense_Mutation	rs528980398	R846H	0.35
COAD	chr11	72015462	Missense_Mutation	rs368335812	R681W	0.32
COAD	chr11	72004747	Nonsense_Mutation	NA	R1967*	0.39
COAD	chr11	72014543	Missense_Mutation	NA	A987V	0.44
COAD	chr11	72017782	Missense_Mutation	novel	N342D	0.31
COAD	chr11	72004313	Missense_Mutation	NA	R2012H	0.26
COAD	chr11	72014304	Missense_Mutation	novel	A1067S	0.25
COAD	chr11	72014943	Missense_Mutation	novel	E854K	0.29
COAD	chr11	72014605	Silent	rs751091506	A966A	0.39
COAD	chr11	72005349	Missense_Mutation	rs760554948	G1905S	0.22
COAD	chr11	72015612	Silent	novel	R631R	0.38
COAD	chr11	72014555	Missense_Mutation	rs761219488	R983Q	0.22
COAD	chr11	72004749	Missense_Mutation	rs754982600	R1966H	0.31
COAD	chr11	72007357	Frame_Shift_Del	NA	*K1766Rfs2**	0.39
COAD	chr11	72015852	Missense_Mutation	novel	H551Y	0.37
COAD	chr11	72019496	Splice_Region	novel	N194N	0.42
COAD	chr11	72009004	Missense_Mutation	rs748328523	R1674H	0.28
COAD	chr11	72016519	Missense_Mutation	novel	E377D	0.27
COAD	chr11	72004748	Silent	NA	R1966R	0.33
COAD	chr11	72009345	Missense_Mutation	rs201665542	R1588C	0.22
COAD	chr11	72015670	In_Frame_Del	novel	K611del	0.12
COAD	chr11	72013745	Missense_Mutation	rs763363698	R1253Q	0.26
COAD	chr11	72007340	Missense_Mutation	novel	E1771G	0.24
COAD	chr11	72014246	Missense_Mutation	novel	T1086I	0.08
COAD	chr11	72004749	Missense_Mutation	rs754982600	R1966H	0.44
COAD	chr11	72022373	Missense_Mutation	NA	P113H	0.3
COAD	chr11	72024333	Missense_Mutation	rs766682349	Q50R	0.27
COAD	chr11	72003466	3'UTR	novel		0.2
COAD	chr11	72008691	Missense_Mutation	novel	T1738S	0.19
COAD	chr11	72007295	Frame_Shift_Ins	NA	*L1786Pfs18**	0.23
COAD	chr11	72014199	Missense_Mutation	rs140741340	A1102T	0.09
COAD	chr11	72008486	Intron	novel		1
COAD	chr11	72009004	Missense_Mutation	rs748328523	R1674H	0.33
COAD	chr11	72014199	Missense_Mutation	rs140741340	A1102T	0.52
COAD	chr11	72035919	Frame_Shift_Del	NA	*A9Lfs7**	0.32
COAD	chr11	72015115	Silent	NA	Q796Q	0.13
ESCA	chr11	72007311	Missense_Mutation	rs529393250	R1781W	0.31
ESCA	chr11	72008080	Intron	novel		0.09
ESCA	chr11	72019616	Splice_Region	novel	A154A	0.37
ESCA	chr11	72015337	Frame_Shift_Ins	novel	*R723Afs16**	0.47
ESCA	chr11	72006067	Missense_Mutation	novel	S1887F	0.08
GBM	chr11	72024286	Missense_Mutation	novel	S66C	0.11
GBM	chr11	72017621	Intron	novel		0.18
GBM	chr11	72019559	Missense_Mutation	novel	H173Q	0.06
GBM	chr11	72004713	Missense_Mutation	novel	G1978D	0.53
GBM	chr11	72007509	Intron	novel		0.14
GBM	chr11	72009186	Splice_Site	novel	X1614_splice	0.22
GBM	chr11	72016192	Missense_Mutation	novel	E437D	0.21
GBM	chr11	72016509	Missense_Mutation	NA	E381K	0.05
GBM	chr11	72015272	Frame_Shift_Ins	novel	*R744Lfs8**	0.14
GBM	chr11	72006225	Silent	rs763350835	S1834S	0.39
GBM	chr11	72012428	Frame_Shift_Ins	novel	*E1541Dfs9**	0.06
GBM	chr11	72010831	Silent	novel	L1558L	0.14
GBM	chr11	72022362	Missense_Mutation	novel	E117K	0.07
GBM	chr11	72006059	Missense_Mutation	rs767774866	G1890R	0.38
GBM	chr11	72013012	Missense_Mutation	novel	E1497D	0.25
GBM	chr11	72018975	Missense_Mutation	novel	L197H	0.08
GBM	chr11	72017779	Nonsense_Mutation	novel	E343*	0.04
GBM	chr11	72017630	Intron	novel		0.53
HNSC	chr11	72004027	Missense_Mutation	rs745630935	R2066W	0.15
HNSC	chr11	72013542	Missense_Mutation	rs754313223	R1321C	0.26
HNSC	chr11	72012949	Missense_Mutation	novel	K1518N	0.26
HNSC	chr11	72012399	Splice_Site	rs767195243	X1550_splice	0.18
HNSC	chr11	72010803	Nonsense_Mutation	novel	Q1568*	0.23
HNSC	chr11	72016257	Frame_Shift_Del	novel	*L415Kfs3**	0.25
HNSC	chr11	72013828	Silent	novel	S1225S	0.24
HNSC	chr11	72014715	Nonsense_Mutation	novel	Q930*	0.28
HNSC	chr11	72013416	Missense_Mutation	novel	A1363T	0.31
HNSC	chr11	72014768	Missense_Mutation	novel	T912S	0.52
HNSC	chr11	72018858	Missense_Mutation	novel	E236V	0.17
HNSC	chr11	72021247	Silent	rs141785503	D139D	0.09
HNSC	chr11	72013887	Missense_Mutation	novel	E1206Q	0.07
HNSC	chr11	72013802	In_Frame_Ins	novel	E1233dup	0.21
HNSC	chr11	72018289	Missense_Mutation	novel	R291L	0.32
HNSC	chr11	72019578	Missense_Mutation	novel	E167G	0.38
HNSC	chr11	72006225	Silent	rs763350835	S1834S	0.11
HNSC	chr11	72014146	Silent	novel	G1119G	0.33
HNSC	chr11	72018832	Missense_Mutation	NA	T245A	0.3
HNSC	chr11	72013602	In_Frame_Del	rs779991584	V1294_E1300del	0.19
HNSC	chr11	72014093	Missense_Mutation	novel	Q1137P	0.22
HNSC	chr11	72003466	3'UTR	novel		0.16
KIRC	chr11	72013380	Missense_Mutation	NA	A1375T	0.41
KIRC	chr11	72022347	Missense_Mutation	novel	K122E	0.45
KIRP	chr11	72005315	Missense_Mutation	novel	D1916G	0.48
KIRP	chr11	72012945	Missense_Mutation	NA	L1520M	0.34
KIRP	chr11	72009054	Silent	novel	H1657H	0.45
KIRP	chr11	72013236	Missense_Mutation	NA	A1423T	0.19
KIRP	chr11	72022390	Frame_Shift_Del	novel	M108*	0.3
LAML	chr11	72010785	Splice_Site	rs775465564	X1573_splice	0.13
LGG	chr11	72007223	Missense_Mutation	rs769008478	R1810H	0.15
LGG	chr11	72014482	Silent	rs752250707	A1007A	0.3
LGG	chr11	72009055	Missense_Mutation	NA	H1657R	0.38
LGG	chr11	72004292	Missense_Mutation	rs781306551	R2019Q	0.35
LGG	chr11	72014385	Missense_Mutation	rs754504305	E1040K	0.35
LGG	chr11	72015649	Missense_Mutation	novel	E618D	0.09
LGG	chr11	72018499	Missense_Mutation	novel	M253V	0.13
LIHC	chr11	72004096	Splice_Site	novel	X2042_splice	0.21
LIHC	chr11	72010787	Missense_Mutation	NA	K1573T	0.13
LIHC	chr11	72010787	Missense_Mutation	NA	K1573T	0.39
LIHC	chr11	72014385	Missense_Mutation	rs754504305	E1040K	0.4
LIHC	chr11	72015163	Silent	novel	A780A	0.38
LIHC	chr11	72015165	Frame_Shift_Del	novel	*A777Lfs31**	0.38
LIHC	chr11	72010796	Frame_Shift_Del	novel	*Q1563Rfs3**	0.08
LUAD	chr11	72006171	Frame_Shift_Del	novel	*A1846Vfs58**	0.06
LUAD	chr11	72013959	Missense_Mutation	rs772480322	Q1182E	0.06
LUAD	chr11	72014371	Frame_Shift_Del	novel	*E1044Vfs52**	0.15
LUAD	chr11	72006055	Frame_Shift_Del	novel	*A1889Gfs44**	0.46
LUAD	chr11	72004242	Missense_Mutation	novel	P2036S	0.06
LUAD	chr11	72004036	Missense_Mutation	novel	L2063V	0.22
LUAD	chr11	72014286	Missense_Mutation	NA	E1073K	0.19
LUAD	chr11	72008835	Missense_Mutation	NA	A1690G	0.09
LUAD	chr11	72008698	Missense_Mutation	novel	S1736G	0.46
LUAD	chr11	72017645	Intron	novel		0.15
LUAD	chr11	72013610	Missense_Mutation	NA	R1298L	0.33
LUAD	chr11	72022353	Missense_Mutation	rs746018990	E120Q	0.05
LUAD	chr11	72015195	Nonsense_Mutation	novel	R770*	0.3
LUAD	chr11	72015303	Missense_Mutation	novel	R734C	0.2
LUAD	chr11	72006248	Missense_Mutation	NA	E1827Q	0.1
LUAD	chr11	72015996	Silent	NA	L503L	0.12
LUAD	chr11	72014342	Missense_Mutation	rs773008059	H1054L	0.04
LUSC	chr11	72013587	Frame_Shift_Del	novel	*V1306Wfs10**	0.19
LUSC	chr11	72004033	Missense_Mutation	novel	L2064V	0.37
LUSC	chr11	72018289	Missense_Mutation	rs764087833	R291Q	0.07
LUSC	chr11	72013435	Silent	novel	L1356L	0.25
LUSC	chr11	72015847	Missense_Mutation	NA	Q552H	0.19
LUSC	chr11	72014199	Missense_Mutation	rs140741340	A1102T	0.11
LUSC	chr11	72013369	Silent	rs755017712	E1378E	0.2
LUSC	chr11	72014024	Missense_Mutation	rs762820306	R1160Q	0.14
LUSC	chr11	72008737	Missense_Mutation	NA	D1723H	0.2
LUSC	chr11	72018209	Nonsense_Mutation	novel	E318*	0.3
LUSC	chr11	72014078	Missense_Mutation	novel	Q1142R	0.17
LUSC	chr11	72013017	Nonsense_Mutation	NA	R1496*	0.15
LUSC	chr11	72014452	Missense_Mutation	novel	Q1017H	0.37
LUSC	chr11	72013192	Silent	NA	L1437L	0.17
LUSC	chr11	72015443	Missense_Mutation	novel	A687V	0.18
LUSC	chr11	72015444	Missense_Mutation	novel	A687P	0.49
OV	chr11	72021278	Missense_Mutation	novel	V129A	0.2
OV	chr11	72007356	Frame_Shift_Ins	NA	*K1766Qfs38**	0.11
OV	chr11	72003976	Missense_Mutation	novel	G2083R	0.12
OV	chr11	72015174	Frame_Shift_Del	novel	*A777Pfs34**	0.17
OV	chr11	72013921	Frame_Shift_Del	novel	*F1195Sfs43**	0.13
OV	chr11	72013680	Missense_Mutation	NA	E1275K	0.39
OV	chr11	72014548	Silent	NA	R985R	0.49
OV	chr11	72018962	Frame_Shift_Ins	novel	*A202Sfs6**	0.16
OV	chr11	72007325	Missense_Mutation	novel	T1776S	0.15
OV	chr11	72015701	Missense_Mutation	rs548451727	A601V	0.24
OV	chr11	72015315	In_Frame_Del	NA	A725_L729del	0.29
OV	chr11	72012438	Missense_Mutation	novel	E1538G	0.06
OV	chr11	72013518	Missense_Mutation	novel	L1329V	0.1
OV	chr11	72013212	Missense_Mutation	rs370967498	A1431T	0.43
OV	chr11	72016179	Missense_Mutation	NA	E442K	0.18
OV	chr11	72017656	Intron	novel		0.38
OV	chr11	72013301	Missense_Mutation	rs200459440	R1401Q	0.08
PAAD	chr11	72009108	Missense_Mutation	novel	E1639D	0.16
PAAD	chr11	72015928	Silent	novel	K525K	0.21
PAAD	chr11	72024298	Missense_Mutation	novel	D62N	0.2
PCPG	chr11	72004316	Frame_Shift_Del	novel	*P2011Hfs4**	0.31
PRAD	chr11	72016143	Missense_Mutation	rs766430228	R454W	0.09
PRAD	chr11	72008784	Frame_Shift_Del	novel	L1707*	0.21
PRAD	chr11	72014732	Missense_Mutation	rs750257826	R924H	0.07
PRAD	chr11	72007402	Silent	novel	S1750S	0.11
PRAD	chr11	72014199	Missense_Mutation	rs140741340	A1102T	0.38
PRAD	chr11	72014481	Missense_Mutation	rs757741335	R1008W	0.31
PRAD	chr11	72014944	Missense_Mutation	novel	K853N	0.15
READ	chr11	72012399	Splice_Site	novel	X1550_splice	0.05
READ	chr11	72014006	Missense_Mutation	NA	T1166I	0.28
READ	chr11	72014007	Missense_Mutation	NA	T1166P	0.28
READ	chr11	72013569	Missense_Mutation	novel	R1312W	0.28
READ	chr11	72015855	Missense_Mutation	rs779257804	R550C	0.28
READ	chr11	72004749	Missense_Mutation	rs754982600	R1966H	0.38
READ	chr11	72008642	Intron	novel		0.39
READ	chr11	72017760	Missense_Mutation	novel	S349I	0.21
READ	chr11	72016509	Missense_Mutation	NA	E381K	0.25
SARC	chr11	72004000	Missense_Mutation	novel	K2075Q	0.21
SKCM	chr11	72014656	Silent	rs771495481	P949P	0.52
SKCM	chr11	72016525	Silent	NA	C375C	0.27
SKCM	chr11	72013393	Silent	novel	L1370L	0.23
SKCM	chr11	72013437	Silent	NA	L1356L	0.31
SKCM	chr11	72016242	Missense_Mutation	NA	E421K	0.53
SKCM	chr11	72019548	Missense_Mutation	NA	R177T	0.1
SKCM	chr11	72005233	Splice_Region	novel	R1943R	0.25
SKCM	chr11	72015432	Missense_Mutation	novel	E691K	0.54
SKCM	chr11	72010818	Nonsense_Mutation	NA	Q1563*	0.15
SKCM	chr11	72021214	Silent	NA	F150F	0.43
SKCM	chr11	72004773	Missense_Mutation	NA	T1958S	0.46
SKCM	chr11	72009144	Silent	NA	Q1627Q	0.1
SKCM	chr11	72014655	Missense_Mutation	rs773373258	E950K	0.13
SKCM	chr11	72023125	Silent	novel	S77S	0.23
SKCM	chr11	72006074	Missense_Mutation	rs745625793	R1885C	0.48
SKCM	chr11	72012986	Missense_Mutation	NA	E1506G	0.38
SKCM	chr11	72004299	Nonsense_Mutation	rs763458607	R2017*	0.31
SKCM	chr11	72007424	Missense_Mutation	novel	R1743H	0.14
SKCM	chr11	72004071	Missense_Mutation	NA	S2051N	0.46
SKCM	chr11	72016470	Silent	NA	L394L	0.42
SKCM	chr11	72015868	Silent	NA	A545A	0.08
STAD	chr11	72007357	Frame_Shift_Del	NA	*K1766Rfs2**	0.21
STAD	chr11	72014199	Missense_Mutation	rs140741340	A1102T	0.21
STAD	chr11	72007523	Intron	novel		0.17
STAD	chr11	72007525	Intron	novel		0.18
STAD	chr11	72006044	Frame_Shift_Del	novel	*A1895Pfs40**	0.29
STAD	chr11	72016000	Silent	rs777949805	A501A	0.16
STAD	chr11	72013952	Missense_Mutation	NA	A1184V	0.36
STAD	chr11	72015248	Missense_Mutation	rs771552205	R752Q	0.5
STAD	chr11	72004067	Silent	NA	I2052I	0.39
STAD	chr11	72009079	Missense_Mutation	rs762537230	R1649Q	0.39
STAD	chr11	72015534	Missense_Mutation	NA	A657T	0.32
STAD	chr11	72013223	Missense_Mutation	NA	R1427Q	0.23
STAD	chr11	72016467	Missense_Mutation	NA	S395P	0.14
STAD	chr11	72009004	Missense_Mutation	rs748328523	R1674H	0.35
STAD	chr11	72018270	Silent	novel	K297K	0.37
STAD	chr11	72005266	Frame_Shift_Ins	novel	*H1933Tfs22**	0.52
STAD	chr11	72015665	Missense_Mutation	NA	K613T	0.27
STAD	chr11	72029213	Silent	novel	I40I	0.11
STAD	chr11	72013647	Missense_Mutation	rs775941295	R1286C	0.2
STAD	chr11	72012428	Missense_Mutation	novel	E1541D	0.29
STAD	chr11	72018394	Splice_Site	NA	X287_splice	0.25
STAD	chr11	72022354	Missense_Mutation	NA	F119L	0.23
STAD	chr11	72003462	3'UTR	novel		0.27
STAD	chr11	72004090	Missense_Mutation	rs113245212	R2045C	0.27
STAD	chr11	72013144	Frame_Shift_Del	NA	*L1454Wfs54**	0.14
STAD	chr11	72015445	Frame_Shift_Del	novel	*A687Qfs25**	0.14
STAD	chr11	72008748	Missense_Mutation	NA	D1719G	0.27
STAD	chr11	72009283	Silent	rs143949849	E1608E	0.24
STAD	chr11	72017714	In_Frame_Del	novel	K364del	0.33
STAD	chr11	72009065	Missense_Mutation	rs746224697	R1654W	0.46
STAD	chr11	72013017	Nonsense_Mutation	NA	R1496*	0.1
STAD	chr11	72015654	Silent	novel	L617L	0.2
STAD	chr11	72013193	Missense_Mutation	NA	L1437P	0.13
STAD	chr11	72003982	Missense_Mutation	rs149006752	R2081C	0.27
STAD	chr11	72013826	Missense_Mutation	NA	L1226P	0.1
STAD	chr11	72021247	Silent	rs141785503	D139D	0.3
STAD	chr11	72018930	Missense_Mutation	novel	P212L	0.24
STAD	chr11	72022398	Missense_Mutation	NA	H105N	0.34
STAD	chr11	72003490	3'UTR	rs535524721		0.27
STAD	chr11	72015631	Silent	NA	L624L	0.16
STAD	chr11	72014732	Missense_Mutation	rs750257826	R924H	0.18
STAD	chr11	72018451	Missense_Mutation	NA	A269T	0.27
STAD	chr11	72007357	Frame_Shift_Del	NA	*K1766Rfs2**	0.13
STAD	chr11	72014332	Silent	rs748155458	T1057T	0.32
STAD	chr11	72014733	Missense_Mutation	rs747075799	R924C	0.27
TGCT	chr11	72004057	Missense_Mutation	novel	P2056S	0.1
THCA	chr11	72023135	Missense_Mutation	NA	H74R	0.39
UCEC	chr11	72013763	Frame_Shift_Ins	novel	*E1247Gfs56**	0.25
UCEC	chr11	72016509	Missense_Mutation	NA	E381K	0.36
UCEC	chr11	72006082	Missense_Mutation	novel	S1882N	0.52
UCEC	chr11	72010834	Silent	novel	K1557K	0.2
UCEC	chr11	72012978	Missense_Mutation	novel	T1509P	0.29
UCEC	chr11	72015330	Missense_Mutation	novel	A725T	0.33
UCEC	chr11	72015598	Missense_Mutation	novel	Q635H	0.16
UCEC	chr11	72013035	Missense_Mutation	rs778315290	R1490C	0.5
UCEC	chr11	72018946	Missense_Mutation	novel	D207N	0.22
UCEC	chr11	72014294	Missense_Mutation	rs150368936	R1070H	0.14
UCEC	chr11	72016131	Missense_Mutation	NA	E458K	0.3
UCEC	chr11	72018204	Missense_Mutation	NA	E319D	0.13
UCEC	chr11	72013734	Missense_Mutation	novel	A1257T	0.58
UCEC	chr11	72002912	3'UTR	novel		0.5
UCEC	chr11	72018954	Missense_Mutation	novel	P204H	0.31
UCEC	chr11	72003455	3'UTR	novel		0.52
UCEC	chr11	72017591	Intron	novel		0.4
UCEC	chr11	72003353	3'UTR	novel		0.39
UCEC	chr11	72003354	3'UTR	novel		0.38
UCEC	chr11	72007266	Missense_Mutation	novel	V1796I	0.5
UCEC	chr11	72013699	Silent	novel	R1268R	0.38
UCEC	chr11	72016131	Missense_Mutation	NA	E458K	0.47
UCEC	chr11	72019614	Missense_Mutation	novel	P155H	0.47
UCEC	chr11	72021220	Missense_Mutation	novel	E148D	0.25
UCEC	chr11	72004021	Missense_Mutation	NA	A2068S	0.38
UCEC	chr11	72014805	Missense_Mutation	novel	D900Y	0.09
UCEC	chr11	72016496	Missense_Mutation	NA	G385V	0.37
UCEC	chr11	72007248	Frame_Shift_Del	novel	*L1798Vfs18**	0.32
UCEC	chr11	72009049	Missense_Mutation	NA	L1659P	0.44
UCEC	chr11	72013517	Missense_Mutation	NA	L1329S	0.35
UCEC	chr11	72018394	Splice_Site	NA	X287_splice	0.42
UCEC	chr11	72014866	Silent	novel	A879A	0.56
UCEC	chr11	72013760	Missense_Mutation	NA	S1248I	0.27
UCEC	chr11	72004280	Missense_Mutation	rs377424025	R2023H	0.2
UCEC	chr11	72015952	Missense_Mutation	novel	Q517H	0.19
UCEC	chr11	72014052	Missense_Mutation	rs770425635	E1151K	0.5
UCEC	chr11	72015907	Silent	NA	Q532Q	0.15
UCEC	chr11	72023094	Silent	NA	L88L	0.36
UCEC	chr11	72013053	Missense_Mutation	rs771295685	R1484C	0.08
UCEC	chr11	72017498	Intron	novel		0.56
UCEC	chr11	72012945	Missense_Mutation	NA	L1520M	0.44
UCEC	chr11	72014428	Silent	novel	A1025A	0.44
UCEC	chr11	72016019	Missense_Mutation	rs781752597	R495Q	0.47
UCEC	chr11	72013501	Silent	novel	E1334E	0.37
UCEC	chr11	72014949	Missense_Mutation	novel	A852T	0.08
UCEC	chr11	72007362	Missense_Mutation	novel	P1764T	0.28
UCEC	chr11	72007363	Silent	novel	L1763L	0.27
UCEC	chr11	72007276	Silent	novel	S1792S	0.19
UCEC	chr11	72014034	Missense_Mutation	rs748699666	R1157W	0.2
UCEC	chr11	72015375	Missense_Mutation	novel	S710P	0.41
UCEC	chr11	72018200	Missense_Mutation	novel	G321R	0.25
UCEC	chr11	72019614	Missense_Mutation	novel	P155H	0.28
UCEC	chr11	72014043	Missense_Mutation	rs61740456	R1154W	0.56
UCEC	chr11	72016177	Silent	NA	E442E	0.32
UCEC	chr11	72012902	Missense_Mutation	novel	T1534I	0.16
UCEC	chr11	72013056	Missense_Mutation	rs567118433	V1483I	0.33
UCEC	chr11	72006098	Missense_Mutation	rs148430833	R1877C	0.49
UCEC	chr11	72013487	Missense_Mutation	novel	K1339T	0.15
UCEC	chr11	72018226	Missense_Mutation	novel	K312R	0.33
UCEC	chr11	72013089	Missense_Mutation	novel	A1472T	0.42
UCEC	chr11	72007424	Missense_Mutation	novel	R1743H	0.6
UCEC	chr11	72014326	Missense_Mutation	novel	K1059N	0.31
UCEC	chr11	72005271	Frame_Shift_Ins	novel	*P1931Sfs5**	0.44
UCEC	chr11	72015095	Missense_Mutation	novel	C803Y	0.15
UCEC	chr11	72003009	3'UTR	novel		0.62
UCEC	chr11	72014370	Missense_Mutation	novel	F1045L	0.06
UCEC	chr11	72014930	Missense_Mutation	novel	G858A	0.3
UCEC	chr11	72015145	Silent	novel	R786R	0.42
UCEC	chr11	72003465	3'UTR	novel		0.31
UCEC	chr11	72005348	Missense_Mutation	novel	G1905D	0.1
UCEC	chr11	72013521	Nonsense_Mutation	novel	E1328*	0.39
UCEC	chr11	72013568	Missense_Mutation	novel	R1312Q	0.24
UCEC	chr11	72008175	Intron	novel		0.2
UCEC	chr11	72015017	Missense_Mutation	NA	A829V	0.08
UCEC	chr11	72035919	Frame_Shift_Del	NA	*A9Lfs7**	0.44
UCEC	chr11	72018428	Missense_Mutation	novel	K276N	0.42
UCEC	chr11	72019539	Missense_Mutation	rs754214935	R180H	0.33
UCEC	chr11	72013066	Missense_Mutation	novel	E1479D	0.36
UCEC	chr11	72013853	Missense_Mutation	rs769235612	R1217Q	0.41
UCEC	chr11	72003074	3'UTR	novel		0.28
UCEC	chr11	72014609	Missense_Mutation	novel	A965V	0.23
UCEC	chr11	72004089	Missense_Mutation	rs746494469	R2045H	0.38
UCEC	chr11	72004686	Missense_Mutation	rs374984536	R1987H	0.32
UCEC	chr11	72013916	Missense_Mutation	rs199732388	R1196H	0.34
UCEC	chr11	72014833	Missense_Mutation	novel	E890D	0.38
UCEC	chr11	72015018	Missense_Mutation	NA	A829T	0.66
UCEC	chr11	72004082	Silent	rs752230112	S2047S	0.27
UCEC	chr11	72013052	Missense_Mutation	NA	R1484H	0.19
UCEC	chr11	72029291	Splice_Site	novel	X15_splice	0.35
UCEC	chr11	72015466	Silent	novel	Q679Q	0.3
UCEC	chr11	72006085	Missense_Mutation	rs777276380	R1881H	0.15
UCEC	chr11	72014934	Missense_Mutation	NA	A857T	0.19
UCEC	chr11	72003235	3'UTR	novel		0.42
UCEC	chr11	72007224	Missense_Mutation	rs779168913	R1810C	0.53
UCEC	chr11	72003918	Missense_Mutation	novel	A2102V	0.07
UCEC	chr11	72006172	Missense_Mutation	novel	S1852Y	0.5
UCEC	chr11	72014800	Silent	rs561672347	D901D	0.25
UCEC	chr11	72013498	In_Frame_Del	novel	K1335del	0.23
UCEC	chr11	72015991	Silent	novel	T504T	0.18
UCEC	chr11	72004083	Missense_Mutation	rs142985752	S2047L	0.34
UCEC	chr11	72014199	Missense_Mutation	rs140741340	A1102T	0.16
UCEC	chr11	72015887	Missense_Mutation	NA	L539P	0.26
UCEC	chr11	72023068	Silent	NA	A96A	0.57
UCEC	chr11	72003305	3'UTR	novel		0.15
UCEC	chr11	72007357	Frame_Shift_Del	NA	*K1766Rfs2**	0.38
UCEC	chr11	72014732	Missense_Mutation	rs750257826	R924H	0.38
UCEC	chr11	72017498	Intron	novel		0.33
UCEC	chr11	72015091	Silent	NA	E804E	0.18
UCEC	chr11	72004281	Missense_Mutation	rs202117024	R2023C	0.16
UCEC	chr11	72005279	Missense_Mutation	rs752057618	R1928Q	0.43
UCEC	chr11	72008825	Missense_Mutation	novel	Q1693H	0.26
UCEC	chr11	72018289	Missense_Mutation	rs764087833	R291Q	0.22
UCEC	chr11	72035973	Splice_Region	rs758022093		0.16
UCEC	chr11	72015922	Silent	novel	Q527Q	0.33
UCEC	chr11	72014733	Missense_Mutation	rs747075799	R924C	0.19
UCEC	chr11	72013464	Nonsense_Mutation	NA	Q1347*	0.39
UCEC	chr11	72006213	Silent	novel	T1838T	0.21
UCEC	chr11	72014259	Missense_Mutation	novel	E1082K	0.4
UCEC	chr11	72014459	Missense_Mutation	novel	R1015H	0.4
UCEC	chr11	72014886	Missense_Mutation	rs1053601	E873K	0.31
UCEC	chr11	72015871	Missense_Mutation	novel	Q544H	0.38
UCS	chr11	72017664	Intron	novel		0.25

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ESCA	AMP	0.3315	0.018342
TGCT	DEL	0.7267	0.21504

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.004	Kaplan-Meier Survival Analysis
MESO	0.00033	Kaplan-Meier Survival Analysis
SKCM	0.039	Kaplan-Meier Survival Analysis
BRCA	0.031	Kaplan-Meier Survival Analysis
ESCA	0.045	Kaplan-Meier Survival Analysis
PAAD	0.011	Kaplan-Meier Survival Analysis
LGG	0.00011	Kaplan-Meier Survival Analysis
UVM	0.012	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000137497 (Gene tree)
Gene ID: 4926
Gene Symbol: NUMA1
Alias: N
Full Name: nuclear mitotic apparatus protein 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 77,830 bases
Position: chr11:72,002,864-72,080,693
Accession: 8059
RBP type: non-canonical RBP
Summary: This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
9112231	Antinuclear autoantibodies: probes for defining proteolytic events associated with apoptosis.	Mol Biol Rep	1996	Casiano CA	-
8760832	Selective cleavage of nuclear autoantigens during CD95 (Fas/APO-1)-mediated T cell apoptosis.	J Exp Med	1996 Aug 1	Casiano CA	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000534971	NUMA1-206	878	-	-	- (aa)	-	-
ENST00000541262	NUMA1-219	706	-	-	- (aa)	-	-
ENST00000544129	NUMA1-227	600	-	ENSP00000439092	159 (aa)	-	F5H2F3
ENST00000542977	NUMA1-223	2766	-	ENSP00000444880	851 (aa)	-	F5H4J1
ENST00000368959	NUMA1-204	583	-	ENSP00000357955	91 (aa)	-	F8W6T3
ENST00000537930	NUMA1-215	582	-	ENSP00000438589	159 (aa)	-	F5H2F3
ENST00000393695	NUMA1-205	7343	XM_006718564	ENSP00000377298	2115 (aa)	XP_006718627	Q14980
ENST00000535111	NUMA1-209	582	-	ENSP00000441674	61 (aa)	-	F5GWA2
ENST00000540626	NUMA1-217	2276	-	-	- (aa)	-	-
ENST00000543009	NUMA1-224	874	-	ENSP00000438821	174 (aa)	-	F5H3L6
ENST00000540588	NUMA1-216	216	-	-	- (aa)	-	-
ENST00000351960	NUMA1-201	3775	-	ENSP00000260051	979 (aa)	-	Q14980
ENST00000358965	NUMA1-202	7227	XM_017017830	ENSP00000351851	2101 (aa)	XP_016873319	Q14980
ENST00000535947	NUMA1-211	576	-	ENSP00000444175	146 (aa)	-	F5GZW1
ENST00000540843	NUMA1-218	1969	-	-	- (aa)	-	-
ENST00000366394	NUMA1-203	539	-	ENSP00000438318	75 (aa)	-	F5H073
ENST00000544238	NUMA1-228	792	-	ENSP00000442761	220 (aa)	-	F5H763
ENST00000534987	NUMA1-207	2211	-	-	- (aa)	-	-
ENST00000616538	NUMA1-233	6998	XM_011545065	ENSP00000481541	2099 (aa)	XP_011543367	A0A087WY61
ENST00000543450	NUMA1-225	3339	-	-	- (aa)	-	-
ENST00000543937	NUMA1-226	911	-	ENSP00000439759	201 (aa)	-	F5H0Z7
ENST00000546131	NUMA1-231	280	-	ENSP00000442331	56 (aa)	-	F5H7R5
ENST00000541641	NUMA1-221	589	-	ENSP00000441598	72 (aa)	-	F5GWK2
ENST00000546036	NUMA1-230	592	-	-	- (aa)	-	-
ENST00000537905	NUMA1-214	598	-	-	- (aa)	-	-
ENST00000541719	NUMA1-222	583	-	ENSP00000438331	82 (aa)	-	F5H068
ENST00000545721	NUMA1-229	2796	-	ENSP00000446396	353 (aa)	-	K4DIE0
ENST00000541584	NUMA1-220	3557	-	ENSP00000440954	964 (aa)	-	H0YFY6
ENST00000537217	NUMA1-213	2331	-	ENSP00000442936	691 (aa)	-	F5H6Y5
ENST00000535838	NUMA1-210	582	-	ENSP00000444831	59 (aa)	-	F5H4Y4
ENST00000620566	NUMA1-234	7012	XM_011545066	ENSP00000478624	2101 (aa)	XP_011543368	Q14980
ENST00000535087	NUMA1-208	606	-	ENSP00000439576	109 (aa)	-	F5H1L0
ENST00000613205	NUMA1-232	3940	-	ENSP00000480172	979 (aa)	-	Q14980
ENST00000536119	NUMA1-212	1686	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000137497's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000137497	Platelet Function Tests	3.8612500E-005	-
ENSG00000137497	Influenza A Virus, H1N1 Subtype	8E-17	26379185
ENSG00000137497	Serologic Tests	8E-7	25758998
ENSG00000137497	Chlamydial Pneumonia	8E-7	25758998

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000137497	rs7122209	11	72055128	C	Antibody level in response to infection	25758998	[NR] unit decrease	1.98	EFO_0007034\|EFO_0007035
ENSG00000137497	rs7116495	11	72051039	?	Severe influenza A (H1N1) infection	26379185			EFO_1001488

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000137497's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000137497	NUMA1	100	89.594	ENSMUSG00000066306	Numa1	99	89.295	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000132	establishment of mitotic spindle orientation	21873635.	IBA	Process
GO:0000132	establishment of mitotic spindle orientation	21816348.	IDA	Process
GO:0000132	establishment of mitotic spindle orientation	24996901.26765568.	IMP	Process
GO:0000132	establishment of mitotic spindle orientation	-	ISS	Process
GO:0000139	Golgi membrane	-	IEA	Component
GO:0000922	spindle pole	21873635.	IBA	Component
GO:0000922	spindle pole	14718566.18331714.23921553.	IDA	Component
GO:0001578	microtubule bundle formation	12445386.	IMP	Process
GO:0005198	structural molecule activity	1541630.	TAS	Function
GO:0005515	protein binding	11590136.11781568.12080061.12445386.15537540.16076287.17172455.20109190.21044950.21816348.22327364.23870127.24996901.25416956.26195665.27462074.	IPI	Function
GO:0005634	nucleus	1541636.23921553.27462074.	IDA	Component
GO:0005654	nucleoplasm	21873635.	IBA	Component
GO:0005654	nucleoplasm	10811826.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005694	chromosome	-	IEA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005813	centrosome	21873635.	IBA	Component
GO:0005813	centrosome	25657325.26562023.26765568.	IDA	Component
GO:0005819	spindle	7004645.	TAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005876	spindle microtubule	21873635.	IBA	Component
GO:0005876	spindle microtubule	1541636.	IDA	Component
GO:0005938	cell cortex	23783028.	IDA	Component
GO:0006997	nucleus organization	1541630.	TAS	Process
GO:0007059	chromosome segregation	-	IEA	Process
GO:0008017	microtubule binding	11956313.12445386.27462074.	IDA	Function
GO:0008022	protein C-terminus binding	20109190.	IMP	Function
GO:0015631	tubulin binding	11956313.	IDA	Function
GO:0016328	lateral plasma membrane	-	IEA	Component
GO:0016363	nuclear matrix	7962183.11956313.	IDA	Component
GO:0019897	extrinsic component of plasma membrane	24371089.24996901.	IDA	Component
GO:0019904	protein domain specific binding	22074847.	IPI	Function
GO:0030425	dendrite	-	IEA	Component
GO:0030513	positive regulation of BMP signaling pathway	-	ISS	Process
GO:0030953	astral microtubule organization	12445386.	IDA	Process
GO:0030953	astral microtubule organization	12445386.	IMP	Process
GO:0031116	positive regulation of microtubule polymerization	12445386.	IMP	Process
GO:0031616	spindle pole centrosome	10811826.	IDA	Component
GO:0032388	positive regulation of intracellular transport	27462074.	IMP	Process
GO:0032991	protein-containing complex	22074847.	IDA	Component
GO:0032991	protein-containing complex	20109190.	IMP	Component
GO:0035091	phosphatidylinositol binding	24371089.24996901.	IDA	Function
GO:0035371	microtubule plus-end	26765568.	IDA	Component
GO:0036449	microtubule minus-end	26765568.	IDA	Component
GO:0043025	neuronal cell body	-	IEA	Component
GO:0044877	protein-containing complex binding	11590136.	IDA	Function
GO:0045618	positive regulation of keratinocyte differentiation	-	ISS	Process
GO:0051010	microtubule plus-end binding	26765568.	IDA	Function
GO:0051011	microtubule minus-end binding	26765568.	IDA	Function
GO:0051301	cell division	-	IEA	Process
GO:0051321	meiotic cell cycle	-	IEA	Process
GO:0051798	positive regulation of hair follicle development	-	ISS	Process
GO:0051984	positive regulation of chromosome segregation	24371089.	IMP	Process
GO:0055028	cortical microtubule	26765568.	IDA	Component
GO:0055048	anastral spindle assembly	25657325.	IMP	Process
GO:0060236	regulation of mitotic spindle organization	26195665.	IDA	Process
GO:0060236	regulation of mitotic spindle organization	11956313.17172455.23027904.24371089.	IMP	Process
GO:0061673	mitotic spindle astral microtubule	1541636.10811826.12445386.24996901.26562023.	IDA	Component
GO:0070062	extracellular exosome	18570454.	HDA	Component
GO:0070840	dynein complex binding	10811826.17172455.22327364.23027904.26195665.	IDA	Function
GO:0072686	mitotic spindle	10811826.26562023.27462074.	IDA	Component
GO:0090235	regulation of metaphase plate congression	27462074.	IMP	Process
GO:0097427	microtubule bundle	11956313.	IDA	Component
GO:0097431	mitotic spindle pole	1541636.7962183.10811826.11781568.11956313.16076287.21816348.22327364.23783028.23870127.24371089.24996901.25657325.26195665.27462074.	IDA	Component
GO:0097431	mitotic spindle pole	17172455.	IMP	Component
GO:0097575	lateral cell cortex	-	ISS	Component
GO:0097718	disordered domain specific binding	20109190.	IMP	Function
GO:0099738	cell cortex region	21816348.22327364.23870127.23921553.24371089.24996901.	IDA	Component
GO:1902365	positive regulation of protein localization to spindle pole body	16076287.	IDA	Process
GO:1902846	positive regulation of mitotic spindle elongation	23921553.	IMP	Process
GO:1904778	positive regulation of protein localization to cell cortex	22327364.23027904.23870127.23921553.24371089.24996901.	IMP	Process
GO:1905720	cytoplasmic microtubule bundle	12445386.	IDA	Component
GO:1905820	positive regulation of chromosome separation	23921553.	IMP	Process
GO:1905832	positive regulation of spindle assembly	27462074.	IMP	Process
GO:1990023	mitotic spindle midzone	10811826.	IDA	Component

EuRBPDB

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Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

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Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.