EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
17540176	The tumor suppressor PP2A Abeta regulates the RalA GTPase.	Cell	2007 Jun 1	Sablina AA	-
17343570	Mutation analysis of the tumor suppressor gene PPP2R1B in human cervical cancer.	Int J Gynecol Cancer	2007 Jul-Aug	Yeh LS	-
26247730	MicroRNA-587 antagonizes 5-FU-induced apoptosis and confers drug resistance by regulating PPP2R1B expression in colorectal cancer.	Cell Death Dis	2015 Aug 6	Zhang Y	doi: 10.1038/cddis.2015.200.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr11	111766287	Silent	novel	I25I	0.07
BLCA	chr11	111766271	Missense_Mutation	rs199554698	E31K	0.16
BLCA	chr11	111765344	Missense_Mutation	NA	L52P	0.35
BLCA	chr11	111765335	Missense_Mutation	novel	G55E	0.3
BLCA	chr11	111766320	Silent	novel	A14A	0.17
BLCA	chr11	111755299	Frame_Shift_Ins	novel	*S280Ffs10**	0.26
BLCA	chr11	111743447	Missense_Mutation	NA	V495I	0.08
BLCA	chr11	111737532	3'Flank	novel		0.23
BLCA	chr11	111766304	Missense_Mutation	rs201793048	D20H	0.13
BLCA	chr11	111743496	Silent	NA	L478L	0.36
BLCA	chr11	111766320	Silent	novel	A14A	0.3
BRCA	chr11	111726970	Missense_Mutation	NA	D667H	0.24
BRCA	chr11	111741410	3'UTR	rs370671556		0.88
CESC	chr11	111766421	5'UTR	novel		0.05
CESC	chr11	111755328	Silent	rs782639209	R270R	0.2
CESC	chr11	111755092	Splice_Region	novel	L282L	0.25
CESC	chr11	111764847	Missense_Mutation	novel	F88L	0.51
CESC	chr11	111766268	Missense_Mutation	novel	L32F	0.39
CESC	chr11	111741547	3'UTR	novel		0.24
CESC	chr11	111764811	Silent	NA	C100C	0.6
COAD	chr11	111747983	Missense_Mutation	NA	S457F	0.4
COAD	chr11	111743463	Missense_Mutation	NA	W489C	0.12
COAD	chr11	111752207	Missense_Mutation	NA	R430S	0.35
COAD	chr11	111741498	3'UTR	novel		0.17
COAD	chr11	111755329	Missense_Mutation	rs781839059	R270H	0.34
COAD	chr11	111742107	Silent	NA	L579L	0.3
COAD	chr11	111754516	Missense_Mutation	NA	I338F	0.24
DLBC	chr11	111742634	In_Frame_Del	novel	T530del	0.13
ESCA	chr11	111764907	Splice_Site	novel	X69_splice	0.45
GBM	chr11	111742568	Missense_Mutation	rs367938997	N551S	0.3
GBM	chr11	111737502	3'Flank	novel		0.1
GBM	chr11	111755030	Missense_Mutation	novel	L303R	0.13
GBM	chr11	111755440	Missense_Mutation	rs564797917	R233H	0.36
GBM	chr11	111759891	Missense_Mutation	novel	K200N	0.05
GBM	chr11	111759811	Missense_Mutation	novel	D227G	0.06
GBM	chr11	111741479	3'UTR	novel		0.5
GBM	chr11	111742533	Missense_Mutation	novel	L563I	0.39
GBM	chr11	111764885	Frame_Shift_Del	novel	*E76Rfs4**	0.05
GBM	chr11	111743432	Missense_Mutation	novel	V500L	0.21
HNSC	chr11	111765315	Missense_Mutation	novel	E62K	0.12
HNSC	chr11	111753556	Missense_Mutation	novel	Q351E	0.21
HNSC	chr11	111759910	Missense_Mutation	novel	R194P	0.1
HNSC	chr11	111765349	In_Frame_Ins	novel	I50dup	0.26
KIRC	chr11	111753526	Frame_Shift_Del	novel	*I361Yfs14**	0.3
KIRC	chr11	111755005	Silent	NA	R311R	0.05
KIRC	chr11	111766266	Silent	novel	L32L	0.28
KIRC	chr11	111753488	Silent	NA	T373T	0.36
KIRP	chr11	111766399	5'UTR	novel		0.2
KIRP	chr11	111743421	Missense_Mutation	novel	N503K	0.05
LAML	chr11	111760962	Silent	novel	T132T	0.34
LAML	chr11	111753541	Missense_Mutation	novel	A356T	0.11
LGG	chr11	111742664	Missense_Mutation	novel	A519V	0.31
LIHC	chr11	111741499	3'UTR	novel		0.21
LIHC	chr11	111753473	Silent	NA	L378L	0.2
LIHC	chr11	111742563	Missense_Mutation	novel	A553T	0.11
LIHC	chr11	111765358	Silent	NA	L47L	0.17
LIHC	chr11	111752221	Missense_Mutation	novel	D426H	0.8
LUAD	chr11	111765332	Missense_Mutation	NA	V56A	0.4
LUAD	chr11	111752228	Silent	NA	L423L	0.22
LUAD	chr11	111765357	Missense_Mutation	NA	S48P	0.07
LUAD	chr11	111755299	Missense_Mutation	novel	S280L	0.18
LUAD	chr11	111754549	Missense_Mutation	novel	I327F	0.24
LUSC	chr11	111742105	Silent	novel	L579L	0.14
LUSC	chr11	111766339	Missense_Mutation	NA	G8V	0.54
LUSC	chr11	111747982	Silent	NA	S457S	0.2
LUSC	chr11	111726997	Missense_Mutation	NA	E658K	0.46
LUSC	chr11	111755441	Missense_Mutation	rs376765814	R233C	0.11
LUSC	chr11	111754539	Missense_Mutation	novel	R330T	0.37
LUSC	chr11	111737503	3'Flank	novel		0.13
OV	chr11	111747999	Missense_Mutation	NA	D452H	0.48
PAAD	chr11	111755441	Missense_Mutation	rs376765814	R233C	0.15
PAAD	chr11	111753498	Missense_Mutation	novel	K370R	0.16
PAAD	chr11	111743466	Missense_Mutation	novel	E488D	0.18
PAAD	chr11	111752270	Silent	novel	I409I	0.2
PRAD	chr11	111754503	Missense_Mutation	NA	I342R	0.41
PRAD	chr11	111754533	Missense_Mutation	novel	T332I	0.32
READ	chr11	111748007	Missense_Mutation	NA	E449A	0.17
READ	chr11	111748003	Missense_Mutation	novel	F450L	0.19
SKCM	chr11	111755324	Missense_Mutation	rs781882991	R272C	0.28
SKCM	chr11	111760990	Missense_Mutation	novel	S123F	0.64
SKCM	chr11	111752324	Silent	rs782707375	D391D	0.34
SKCM	chr11	111765380	Missense_Mutation	NA	R40Q	0.67
SKCM	chr11	111753471	Missense_Mutation	novel	P379L	0.21
SKCM	chr11	111753472	Missense_Mutation	novel	P379S	0.21
SKCM	chr11	111765319	Silent	novel	R60R	0.16
SKCM	chr11	111765320	Missense_Mutation	novel	R60Q	0.15
SKCM	chr11	111765385	Splice_Site	novel	X39_splice	0.43
SKCM	chr11	111755048	Missense_Mutation	novel	P297L	0.19
STAD	chr11	111742052	Splice_Site	novel	X597_splice	0.43
STAD	chr11	111742107	Silent	NA	L579L	0.29
STAD	chr11	111754539	Missense_Mutation	novel	R330I	0.16
STAD	chr11	111742580	Missense_Mutation	NA	N547I	0.21
STAD	chr11	111759856	Frame_Shift_Del	NA	*D211Vfs2**	0.38
STAD	chr11	111752197	Missense_Mutation	novel	A434T	0.08
STAD	chr11	111761009	Missense_Mutation	rs782083920	R117C	0.22
STAD	chr11	111752296	Missense_Mutation	NA	D401Y	0.13
STAD	chr11	111727016	Silent	NA	L651L	0.24
STAD	chr11	111748012	Splice_Region	NA	G447G	0.26
STAD	chr11	111761028	Silent	NA	T110T	0.16
STAD	chr11	111742118	Missense_Mutation	NA	V575A	0.18
STAD	chr11	111754533	Missense_Mutation	NA	T332S	0.08
UCEC	chr11	111742066	Missense_Mutation	novel	Q592H	0.28
UCEC	chr11	111760875	Silent	novel	G161G	0.12
UCEC	chr11	111737455	3'Flank	NA		0.27
UCEC	chr11	111766249	Missense_Mutation	NA	Q38R	0.26
UCEC	chr11	111741561	3'UTR	novel		0.14
UCEC	chr11	111747983	Missense_Mutation	NA	S457F	0.44
UCEC	chr11	111760994	Nonsense_Mutation	NA	E122*	0.42
UCEC	chr11	111752189	Silent	NA	I436I	0.33
UCEC	chr11	111741380	3'UTR	rs553623756		0.42
UCEC	chr11	111753449	Missense_Mutation	novel	K386N	0.37
UCEC	chr11	111753568	Missense_Mutation	novel	S347A	0.17
UCEC	chr11	111743453	Missense_Mutation	novel	T493A	0.08
UCEC	chr11	111765352	Silent	novel	T49T	0.07
UCEC	chr11	111754531	Missense_Mutation	rs782434436	I333V	0.23
UCEC	chr11	111755376	Silent	novel	T254T	0.37
UCEC	chr11	111759907	Missense_Mutation	rs371282382	R195H	0.38
UCEC	chr11	111727043	Silent	novel	Q642Q	0.33
UCEC	chr11	111741465	3'UTR	novel		0.29
UCEC	chr11	111726995	Missense_Mutation	novel	E658D	0.47
UCEC	chr11	111741414	3'UTR	novel		0.32
UCEC	chr11	111742098	Missense_Mutation	novel	D582Y	0.4
UCEC	chr11	111741465	3'UTR	novel		0.34
UCEC	chr11	111727023	Missense_Mutation	novel	D649G	0.31
UCEC	chr11	111765303	Missense_Mutation	novel	F66L	0.22
UCEC	chr11	111755328	Silent	rs782639209	R270R	0.36
UCEC	chr11	111754543	Missense_Mutation	novel	D329Y	0.15
UCEC	chr11	111741413	3'UTR	novel		0.43
UCEC	chr11	111755051	Missense_Mutation	novel	I296T	0.27
UCEC	chr11	111755007	Missense_Mutation	rs782673348	R311W	0.41
UCEC	chr11	111759837	Silent	NA	V218V	0.28
UCEC	chr11	111742145	Splice_Site	novel	X566_splice	0.28
UCEC	chr11	111742633	Silent	novel	T529T	0.38
UCEC	chr11	111741465	3'UTR	novel		0.25
UCEC	chr11	111747957	Missense_Mutation	novel	H466Y	0.43
UCEC	chr11	111759907	Missense_Mutation	rs371282382	R195H	0.23
UCEC	chr11	111760882	Missense_Mutation	novel	A159V	0.52
UCEC	chr11	111761220	Intron	novel		0.5
UCEC	chr11	111764854	Missense_Mutation	novel	G86E	0.2
UCEC	chr11	111765306	Missense_Mutation	novel	P65S	0.14
UCEC	chr11	111741466	3'UTR	novel		0.59
UCEC	chr11	111741519	3'UTR	novel		0.4
UCEC	chr11	111755407	Missense_Mutation	novel	A244V	0.45
UCEC	chr11	111760865	Missense_Mutation	novel	V165I	0.38
UCEC	chr11	111741135	3'UTR	novel		0.65
UCEC	chr11	111752268	Missense_Mutation	rs530683430	R410H	0.38
UCEC	chr11	111741338	3'UTR	novel		0.28
UCEC	chr11	111752330	Missense_Mutation	novel	C389W	0.23
UVM	chr11	111765340	Silent	novel	A53A	0.49

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.2892	0.00015732
BRCA	DEL	0.4583	7.1709e-58
CESC	DEL	0.4983	1.0762e-32
CHOL	DEL	0.3056	0.048655
ESCA	AMP	0.1141	0.018342
HNSC	DEL	0.41	1.8879e-21
KIRP	DEL	0.1042	2.839e-05
LIHC	DEL	0.1973	0.00030497
LUAD	DEL	0.1725	4.2393e-06
MESO	DEL	0.1609	0.0023183
PRAD	DEL	0.0732	0.00026046
READ	DEL	0.2061	0.054114
SARC	DEL	0.4319	1.8105e-09
STAD	DEL	0.1497	8.3734e-05
TGCT	DEL	0.7667	0.21504
UCS	DEL	0.3929	0.086462

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.002	Kaplan-Meier Survival Analysis
SARC	0.0082	Kaplan-Meier Survival Analysis
ACC	0.037	Kaplan-Meier Survival Analysis
KIRP	0.023	Kaplan-Meier Survival Analysis
READ	0.0081	Kaplan-Meier Survival Analysis
UCEC	0.0023	Kaplan-Meier Survival Analysis
LIHC	0.0012	Kaplan-Meier Survival Analysis
LGG	0.0012	Kaplan-Meier Survival Analysis
LUAD	0.025	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000137713 (Gene tree)
Gene ID: 5519
Gene Symbol: PPP2R1B
Alias: PR65B|PP2A-Abeta
Full Name: protein phosphatase 2 scaffold subunit Abeta
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 71,372 bases
Position: chr11:111,695,074-111,766,445
Accession: 9303
RBP type: non-canonical RBP
Summary: This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000341980	PPP2R1B-202	1953	-	ENSP00000343317	556 (aa)	-	P30154
ENST00000426998	PPP2R1B-204	1888	-	ENSP00000410671	603 (aa)	-	P30154
ENST00000393055	PPP2R1B-203	1525	-	ENSP00000376775	474 (aa)	-	P30154
ENST00000527614	PPP2R1B-206	5587	XM_017017961	ENSP00000437193	601 (aa)	XP_016873450	P30154
ENST00000531890	PPP2R1B-210	670	-	ENSP00000433598	224 (aa)	-	H0YDG7
ENST00000531373	PPP2R1B-209	553	-	ENSP00000434705	119 (aa)	-	E9PNM7
ENST00000534500	PPP2R1B-211	582	-	ENSP00000432666	83 (aa)	-	E9PPI5
ENST00000530787	PPP2R1B-208	131	-	-	- (aa)	-	-
ENST00000529672	PPP2R1B-207	874	-	-	- (aa)	-	-
ENST00000534521	PPP2R1B-212	2294	-	ENSP00000436626	135 (aa)	-	E9PHZ6
ENST00000311129	PPP2R1B-201	2082	XM_017017960	ENSP00000311344	667 (aa)	XP_016873449	P30154
ENST00000526287	PPP2R1B-205	101	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000137713's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03015	mRNA surveillance pathway	KEGG
hsa04071	Sphingolipid signaling pathway	KEGG
hsa04114	Oocyte meiosis	KEGG
hsa04151	PI3K-Akt signaling pathway	KEGG
hsa04152	AMPK signaling pathway	KEGG
hsa04261	Adrenergic signaling in cardiomyocytes	KEGG
hsa04350	TGF-beta signaling pathway	KEGG
hsa04390	Hippo signaling pathway	KEGG
hsa04530	Tight junction	KEGG
hsa04728	Dopaminergic synapse	KEGG
hsa04730	Long-term depression	KEGG
hsa05142	Chagas disease (American trypanosomiasis)	KEGG
hsa05160	Hepatitis C	KEGG
hsa05165	Human papillomavirus infection	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000137713	Myocardial Infarction	2.1990000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000137713	rs11213999	11	111763868	A	Facial wrinkles	29555444	[NR] z score decrease	5.04	HP_0009762
ENSG00000137713	rs4936675	11	111752364	?	Mean corpuscular hemoglobin	30595370			EFO_0004527
ENSG00000137713	rs643506	11	111765903	G	Breast cancer	29059683	[0.021-0.047] unit decrease	0.0344	EFO_0000305

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000137713's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000137713	PPP2R1B	79	85.106	WBGene00003901	paa-1	98	62.544	Caenorhabditis_elegans
ENSG00000137713	PPP2R1B	96	71.848	FBgn0260439	Pp2A-29B	98	72.021	Drosophila_melanogaster
ENSG00000137713	PPP2R1B	98	86.224	ENSG00000105568	PPP2R1A	99	86.403	Homo_sapiens
ENSG00000137713	PPP2R1B	97	96.207	ENSMUSG00000032058	Ppp2r1b	100	95.674	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000159	protein phosphatase type 2A complex	21873635.	IBA	Component
GO:0004722	protein serine/threonine phosphatase activity	21873635.	IBA	Function
GO:0005515	protein binding	8392071.16456541.17540176.18715871.18782753.19156129.21172653.23555304.26496610.28330616.	IPI	Function
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0006470	protein dephosphorylation	-	IEA	Process
GO:0019888	protein phosphatase regulator activity	21873635.	IBA	Function
GO:0043666	regulation of phosphoprotein phosphatase activity	-	IEA	Process
GO:0045121	membrane raft	21172653.	IDA	Component
GO:0060561	apoptotic process involved in morphogenesis	21172653.	IMP	Process
GO:0070062	extracellular exosome	23533145.	HDA	Component
GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	21172653.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.