EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
17540176The tumor suppressor PP2A Abeta regulates the RalA GTPase.Cell2007 Jun 1Sablina AA-
17343570Mutation analysis of the tumor suppressor gene PPP2R1B in human cervical cancer.Int J Gynecol Cancer2007 Jul-AugYeh LS-
26247730MicroRNA-587 antagonizes 5-FU-induced apoptosis and confers drug resistance by regulating PPP2R1B expression in colorectal cancer.Cell Death Dis2015 Aug 6Zhang Ydoi: 10.1038/cddis.2015.200.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr11111766287SilentnovelI25I0.07
BLCAchr11111766271Missense_Mutationrs199554698E31K0.16
BLCAchr11111765344Missense_MutationNAL52P0.35
BLCAchr11111765335Missense_MutationnovelG55E0.3
BLCAchr11111766320SilentnovelA14A0.17
BLCAchr11111755299Frame_Shift_InsnovelS280Ffs*100.26
BLCAchr11111743447Missense_MutationNAV495I0.08
BLCAchr111117375323'Flanknovel0.23
BLCAchr11111766304Missense_Mutationrs201793048D20H0.13
BLCAchr11111743496SilentNAL478L0.36
BLCAchr11111766320SilentnovelA14A0.3
BRCAchr11111726970Missense_MutationNAD667H0.24
BRCAchr111117414103'UTRrs3706715560.88
CESCchr111117664215'UTRnovel0.05
CESCchr11111755328Silentrs782639209R270R0.2
CESCchr11111755092Splice_RegionnovelL282L0.25
CESCchr11111764847Missense_MutationnovelF88L0.51
CESCchr11111766268Missense_MutationnovelL32F0.39
CESCchr111117415473'UTRnovel0.24
CESCchr11111764811SilentNAC100C0.6
COADchr11111747983Missense_MutationNAS457F0.4
COADchr11111743463Missense_MutationNAW489C0.12
COADchr11111752207Missense_MutationNAR430S0.35
COADchr111117414983'UTRnovel0.17
COADchr11111755329Missense_Mutationrs781839059R270H0.34
COADchr11111742107SilentNAL579L0.3
COADchr11111754516Missense_MutationNAI338F0.24
DLBCchr11111742634In_Frame_DelnovelT530del0.13
ESCAchr11111764907Splice_SitenovelX69_splice0.45
GBMchr11111742568Missense_Mutationrs367938997N551S0.3
GBMchr111117375023'Flanknovel0.1
GBMchr11111755030Missense_MutationnovelL303R0.13
GBMchr11111755440Missense_Mutationrs564797917R233H0.36
GBMchr11111759891Missense_MutationnovelK200N0.05
GBMchr11111759811Missense_MutationnovelD227G0.06
GBMchr111117414793'UTRnovel0.5
GBMchr11111742533Missense_MutationnovelL563I0.39
GBMchr11111764885Frame_Shift_DelnovelE76Rfs*40.05
GBMchr11111743432Missense_MutationnovelV500L0.21
HNSCchr11111765315Missense_MutationnovelE62K0.12
HNSCchr11111753556Missense_MutationnovelQ351E0.21
HNSCchr11111759910Missense_MutationnovelR194P0.1
HNSCchr11111765349In_Frame_InsnovelI50dup0.26
KIRCchr11111753526Frame_Shift_DelnovelI361Yfs*140.3
KIRCchr11111755005SilentNAR311R0.05
KIRCchr11111766266SilentnovelL32L0.28
KIRCchr11111753488SilentNAT373T0.36
KIRPchr111117663995'UTRnovel0.2
KIRPchr11111743421Missense_MutationnovelN503K0.05
LAMLchr11111760962SilentnovelT132T0.34
LAMLchr11111753541Missense_MutationnovelA356T0.11
LGGchr11111742664Missense_MutationnovelA519V0.31
LIHCchr111117414993'UTRnovel0.21
LIHCchr11111753473SilentNAL378L0.2
LIHCchr11111742563Missense_MutationnovelA553T0.11
LIHCchr11111765358SilentNAL47L0.17
LIHCchr11111752221Missense_MutationnovelD426H0.8
LUADchr11111765332Missense_MutationNAV56A0.4
LUADchr11111752228SilentNAL423L0.22
LUADchr11111765357Missense_MutationNAS48P0.07
LUADchr11111755299Missense_MutationnovelS280L0.18
LUADchr11111754549Missense_MutationnovelI327F0.24
LUSCchr11111742105SilentnovelL579L0.14
LUSCchr11111766339Missense_MutationNAG8V0.54
LUSCchr11111747982SilentNAS457S0.2
LUSCchr11111726997Missense_MutationNAE658K0.46
LUSCchr11111755441Missense_Mutationrs376765814R233C0.11
LUSCchr11111754539Missense_MutationnovelR330T0.37
LUSCchr111117375033'Flanknovel0.13
OVchr11111747999Missense_MutationNAD452H0.48
PAADchr11111755441Missense_Mutationrs376765814R233C0.15
PAADchr11111753498Missense_MutationnovelK370R0.16
PAADchr11111743466Missense_MutationnovelE488D0.18
PAADchr11111752270SilentnovelI409I0.2
PRADchr11111754503Missense_MutationNAI342R0.41
PRADchr11111754533Missense_MutationnovelT332I0.32
READchr11111748007Missense_MutationNAE449A0.17
READchr11111748003Missense_MutationnovelF450L0.19
SKCMchr11111755324Missense_Mutationrs781882991R272C0.28
SKCMchr11111760990Missense_MutationnovelS123F0.64
SKCMchr11111752324Silentrs782707375D391D0.34
SKCMchr11111765380Missense_MutationNAR40Q0.67
SKCMchr11111753471Missense_MutationnovelP379L0.21
SKCMchr11111753472Missense_MutationnovelP379S0.21
SKCMchr11111765319SilentnovelR60R0.16
SKCMchr11111765320Missense_MutationnovelR60Q0.15
SKCMchr11111765385Splice_SitenovelX39_splice0.43
SKCMchr11111755048Missense_MutationnovelP297L0.19
STADchr11111742052Splice_SitenovelX597_splice0.43
STADchr11111742107SilentNAL579L0.29
STADchr11111754539Missense_MutationnovelR330I0.16
STADchr11111742580Missense_MutationNAN547I0.21
STADchr11111759856Frame_Shift_DelNAD211Vfs*20.38
STADchr11111752197Missense_MutationnovelA434T0.08
STADchr11111761009Missense_Mutationrs782083920R117C0.22
STADchr11111752296Missense_MutationNAD401Y0.13
STADchr11111727016SilentNAL651L0.24
STADchr11111748012Splice_RegionNAG447G0.26
STADchr11111761028SilentNAT110T0.16
STADchr11111742118Missense_MutationNAV575A0.18
STADchr11111754533Missense_MutationNAT332S0.08
UCECchr11111742066Missense_MutationnovelQ592H0.28
UCECchr11111760875SilentnovelG161G0.12
UCECchr111117374553'FlankNA0.27
UCECchr11111766249Missense_MutationNAQ38R0.26
UCECchr111117415613'UTRnovel0.14
UCECchr11111747983Missense_MutationNAS457F0.44
UCECchr11111760994Nonsense_MutationNAE122*0.42
UCECchr11111752189SilentNAI436I0.33
UCECchr111117413803'UTRrs5536237560.42
UCECchr11111753449Missense_MutationnovelK386N0.37
UCECchr11111753568Missense_MutationnovelS347A0.17
UCECchr11111743453Missense_MutationnovelT493A0.08
UCECchr11111765352SilentnovelT49T0.07
UCECchr11111754531Missense_Mutationrs782434436I333V0.23
UCECchr11111755376SilentnovelT254T0.37
UCECchr11111759907Missense_Mutationrs371282382R195H0.38
UCECchr11111727043SilentnovelQ642Q0.33
UCECchr111117414653'UTRnovel0.29
UCECchr11111726995Missense_MutationnovelE658D0.47
UCECchr111117414143'UTRnovel0.32
UCECchr11111742098Missense_MutationnovelD582Y0.4
UCECchr111117414653'UTRnovel0.34
UCECchr11111727023Missense_MutationnovelD649G0.31
UCECchr11111765303Missense_MutationnovelF66L0.22
UCECchr11111755328Silentrs782639209R270R0.36
UCECchr11111754543Missense_MutationnovelD329Y0.15
UCECchr111117414133'UTRnovel0.43
UCECchr11111755051Missense_MutationnovelI296T0.27
UCECchr11111755007Missense_Mutationrs782673348R311W0.41
UCECchr11111759837SilentNAV218V0.28
UCECchr11111742145Splice_SitenovelX566_splice0.28
UCECchr11111742633SilentnovelT529T0.38
UCECchr111117414653'UTRnovel0.25
UCECchr11111747957Missense_MutationnovelH466Y0.43
UCECchr11111759907Missense_Mutationrs371282382R195H0.23
UCECchr11111760882Missense_MutationnovelA159V0.52
UCECchr11111761220Intronnovel0.5
UCECchr11111764854Missense_MutationnovelG86E0.2
UCECchr11111765306Missense_MutationnovelP65S0.14
UCECchr111117414663'UTRnovel0.59
UCECchr111117415193'UTRnovel0.4
UCECchr11111755407Missense_MutationnovelA244V0.45
UCECchr11111760865Missense_MutationnovelV165I0.38
UCECchr111117411353'UTRnovel0.65
UCECchr11111752268Missense_Mutationrs530683430R410H0.38
UCECchr111117413383'UTRnovel0.28
UCECchr11111752330Missense_MutationnovelC389W0.23
UVMchr11111765340SilentnovelA53A0.49

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BLCADEL0.28920.00015732
BRCADEL0.45837.1709e-58
CESCDEL0.49831.0762e-32
CHOLDEL0.30560.048655
ESCAAMP0.11410.018342
HNSCDEL0.411.8879e-21
KIRPDEL0.10422.839e-05
LIHCDEL0.19730.00030497
LUADDEL0.17254.2393e-06
MESODEL0.16090.0023183
PRADDEL0.07320.00026046
READDEL0.20610.054114
SARCDEL0.43191.8105e-09
STADDEL0.14978.3734e-05
TGCTDEL0.76670.21504
UCSDEL0.39290.086462

Survival Analysis
CancerP-value Q-value
KIRC0.002

Kaplan-Meier Survival Analysis

SARC0.0082

Kaplan-Meier Survival Analysis

ACC0.037

Kaplan-Meier Survival Analysis

KIRP0.023

Kaplan-Meier Survival Analysis

READ0.0081

Kaplan-Meier Survival Analysis

UCEC0.0023

Kaplan-Meier Survival Analysis

LIHC0.0012

Kaplan-Meier Survival Analysis

LGG0.0012

Kaplan-Meier Survival Analysis

LUAD0.025

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000137713 (Gene tree)
Gene ID
5519
Gene Symbol
PPP2R1B
Alias
PR65B|PP2A-Abeta
Full Name
protein phosphatase 2 scaffold subunit Abeta
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Minus strand
Length
71,372 bases
Position
chr11:111,695,074-111,766,445
Accession
9303
RBP type
non-canonical RBP
Summary
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000341980PPP2R1B-2021953-ENSP00000343317556 (aa)-P30154
ENST00000426998PPP2R1B-2041888-ENSP00000410671603 (aa)-P30154
ENST00000393055PPP2R1B-2031525-ENSP00000376775474 (aa)-P30154
ENST00000527614PPP2R1B-2065587XM_017017961ENSP00000437193601 (aa)XP_016873450P30154
ENST00000531890PPP2R1B-210670-ENSP00000433598224 (aa)-H0YDG7
ENST00000531373PPP2R1B-209553-ENSP00000434705119 (aa)-E9PNM7
ENST00000534500PPP2R1B-211582-ENSP0000043266683 (aa)-E9PPI5
ENST00000530787PPP2R1B-208131--- (aa)--
ENST00000529672PPP2R1B-207874--- (aa)--
ENST00000534521PPP2R1B-2122294-ENSP00000436626135 (aa)-E9PHZ6
ENST00000311129PPP2R1B-2012082XM_017017960ENSP00000311344667 (aa)XP_016873449P30154
ENST00000526287PPP2R1B-205101--- (aa)--
Gene Model
Click here to download ENSG00000137713's gene model file
Pathways
Pathway IDPathway NameSource
hsa03015mRNA surveillance pathwayKEGG
hsa04071Sphingolipid signaling pathwayKEGG
hsa04114Oocyte meiosisKEGG
hsa04151PI3K-Akt signaling pathwayKEGG
hsa04152AMPK signaling pathwayKEGG
hsa04261Adrenergic signaling in cardiomyocytesKEGG
hsa04350TGF-beta signaling pathwayKEGG
hsa04390Hippo signaling pathwayKEGG
hsa04530Tight junctionKEGG
hsa04728Dopaminergic synapseKEGG
hsa04730Long-term depressionKEGG
hsa05142Chagas disease (American trypanosomiasis)KEGG
hsa05160Hepatitis CKEGG
hsa05165Human papillomavirus infectionKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000137713Myocardial Infarction2.1990000E-005-
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000137713rs1121399911111763868AFacial wrinkles29555444[NR] z score decrease5.04HP_0009762
ENSG00000137713rs493667511111752364?Mean corpuscular hemoglobin30595370EFO_0004527
ENSG00000137713rs64350611111765903GBreast cancer29059683[0.021-0.047] unit decrease0.0344EFO_0000305
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000137713's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000137713PPP2R1B7985.106WBGene00003901paa-19862.544Caenorhabditis_elegans
ENSG00000137713PPP2R1B9671.848FBgn0260439Pp2A-29B9872.021Drosophila_melanogaster
ENSG00000137713PPP2R1B9886.224ENSG00000105568PPP2R1A9986.403Homo_sapiens
ENSG00000137713PPP2R1B9796.207ENSMUSG00000032058Ppp2r1b10095.674Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000159protein phosphatase type 2A complex21873635.IBAComponent
GO:0004722protein serine/threonine phosphatase activity21873635.IBAFunction
GO:0005515protein binding8392071.16456541.17540176.18715871.18782753.19156129.21172653.23555304.26496610.28330616.IPIFunction
GO:0005737cytoplasm21873635.IBAComponent
GO:0006470protein dephosphorylation-IEAProcess
GO:0019888protein phosphatase regulator activity21873635.IBAFunction
GO:0043666regulation of phosphoprotein phosphatase activity-IEAProcess
GO:0045121membrane raft21172653.IDAComponent
GO:0060561apoptotic process involved in morphogenesis21172653.IMPProcess
GO:0070062extracellular exosome23533145.HDAComponent
GO:2001241positive regulation of extrinsic apoptotic signaling pathway in absence of ligand21172653.IMPProcess
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