EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26554377	Down-Regulation of Nucleolar and Spindle-Associated Protein 1 (NUSAP1) Expression Suppresses Tumor and Cell Proliferation and Enhances Anti-Tumor Effect of Paclitaxel in Oral Squamous Cell Carcinoma.	PLoS One	2015 Nov 10	Okamoto A	doi: 10.1371/journal.pone.0142252
20053754	Antibodies specifically target AML antigen NuSAP1 after allogeneic bone marrow transplantation.	Blood	2010 Mar 11	Wadia PP	doi: 10.1182/blood-2009-03-211375
29853313	High NUSAP1 expression predicts poor prognosis in colon cancer.	Pathol Res Pract	2018 Jul	Liu Z	doi: 10.1016/j.prp.2018.05.017
30678687	Nucleolar and spindle associated protein 1 promotes metastasis of cervical carcinoma cells by activating Wnt/β-catenin signaling.	J Exp Clin Cancer Res	2019 Jan 24	Li H	doi: 10.1186/s13046-019-1037-y.
22349817	Increased expression of NuSAP in recurrent prostate cancer is mediated by E2F1.	Oncogene	2013 Jan 3	Gulzar ZG	doi: 10.1038/onc.2012.27
26485712	High Levels of Nucleolar Spindle-Associated Protein and Reduced Levels of BRCA1 Expression Predict Poor Prognosis in Triple-Negative Breast Cancer.	PLoS One	2015 Oct 20	Chen L	doi: 10.1371/journal.pone.0140572
23405241	Mitosis is a source of potential markers for screening and survival and therapeutic targets in cervical cancer.	PLoS One	2013	Espinosa AM	doi: 10.1371/journal.pone.0055975
29608915	NUSAP1 gene silencing inhibits cell proliferation, migration and invasion through inhibiting DNMT1 gene expression in human colorectal cancer.	Exp Cell Res	2018 Jun 15	Han G	doi: 10.1016/j.yexcr.2018.03.039

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr15	41332976	Missense_Mutation	NA	E7Q	0.23
BLCA	chr15	41349167	Missense_Mutation	novel	E78Q	0.24
BLCA	chr15	41375780	Missense_Mutation	novel	D359H	0.09
BLCA	chr15	41356089	Missense_Mutation	NA	D167Y	0.23
BLCA	chr15	41365539	Silent	NA	L266L	0.18
BLCA	chr15	41365568	Missense_Mutation	novel	S276C	0.53
BLCA	chr15	41365448	Missense_Mutation	NA	R236T	0.57
BLCA	chr15	41365435	Missense_Mutation	novel	P232A	0.3
BRCA	chr15	41332989	Missense_Mutation	NA	S11C	0.26
BRCA	chr15	41380221	3'UTR	novel		0.06
CESC	chr15	41375731	Missense_Mutation	novel	L342F	0.26
CESC	chr15	41332976	Missense_Mutation	rs745709236	E7K	0.13
CESC	chr15	41371561	Missense_Mutation	rs748216021	R295C	0.27
CESC	chr15	41351062	Silent	NA	L127L	0.24
CESC	chr15	41332865	5'Flank	NA		0.71
COAD	chr15	41349172	Silent	novel	R79R	0.09
COAD	chr15	41332850	5'Flank	novel		0.41
COAD	chr15	41380244	3'UTR	novel		0.31
COAD	chr15	41365555	Missense_Mutation	novel	R272C	0.18
COAD	chr15	41365520	Missense_Mutation	NA	S260T	0.16
HNSC	chr15	41349169	Silent	novel	E78E	0.15
HNSC	chr15	41351117	Missense_Mutation	novel	A146T	0.2
KIRP	chr15	41365528	Missense_Mutation	NA	T263A	0.39
KIRP	chr15	41380447	3'Flank	novel		0.42
KIRP	chr15	41377297	Nonsense_Mutation	NA	Q409*	0.36
LGG	chr15	41375766	Missense_Mutation	novel	K354R	0.12
LIHC	chr15	41365400	Splice_Site	novel	X221_splice	0.46
LIHC	chr15	41332829	5'Flank	novel		0.26
LUAD	chr15	41332963	Missense_Mutation	novel	I2M	0.15
LUAD	chr15	41365579	Missense_Mutation	novel	T280A	0.82
LUAD	chr15	41365469	Missense_Mutation	NA	S243Y	0.52
LUAD	chr15	41375776	Silent	novel	V357V	0.29
LUSC	chr15	41375826	Missense_Mutation	NA	K374T	0.13
LUSC	chr15	41358196	Missense_Mutation	NA	D200H	0.19
LUSC	chr15	41371676	Missense_Mutation	novel	S333F	0.18
OV	chr15	41349183	Missense_Mutation	NA	G83D	0.13
OV	chr15	41365560	Silent	novel	S273S	0.31
PAAD	chr15	41365503	Silent	novel	R254R	0.18
READ	chr15	41332906	5'UTR	novel		0.42
READ	chr15	41351029	Missense_Mutation	novel	F116L	0.44
SKCM	chr15	41351036	Missense_Mutation	NA	H119Y	0.33
SKCM	chr15	41351065	Missense_Mutation	NA	R128S	0.37
SKCM	chr15	41351062	Silent	NA	L127L	0.52
STAD	chr15	41375745	Missense_Mutation	NA	T347M	0.35
STAD	chr15	41358214	Missense_Mutation	rs773154411	K206E	0.21
STAD	chr15	41349221	Missense_Mutation	rs775051382	R96C	0.28
STAD	chr15	41358249	Silent	NA	N217N	0.23
TGCT	chr15	41332909	5'UTR	novel		0.32
THYM	chr15	41332920	5'UTR	novel		0.32
UCEC	chr15	41351011	Missense_Mutation	NA	I110M	0.3
UCEC	chr15	41332920	5'UTR	novel		0.33
UCEC	chr15	41380124	Nonsense_Mutation	NA	R422*	0.33
UCEC	chr15	41351130	Splice_Site	novel	X150_splice	0.46
UCEC	chr15	41380190	3'UTR	novel		0.45
UCEC	chr15	41375795	Silent	novel	L364L	0.2
UCEC	chr15	41365558	Missense_Mutation	NA	S273T	0.24
UCEC	chr15	41349147	Missense_Mutation	NA	I71N	0.23
UCEC	chr15	41380125	Missense_Mutation	rs370147837	R422Q	0.42
UCEC	chr15	41365524	Missense_Mutation	NA	Q261H	0.24
UCEC	chr15	41380114	Silent	rs187207613	R418R	0.2
UCEC	chr15	41365486	Nonsense_Mutation	rs202144126	R249*	0.26
UCEC	chr15	41351093	Missense_Mutation	rs189325557	D138H	0.2
UCEC	chr15	41356080	Missense_Mutation	novel	L164I	0.3
UCEC	chr15	41371606	Missense_Mutation	rs574269860	V310M	0.38
UCEC	chr15	41351081	Missense_Mutation	novel	P134S	0.13
UCEC	chr15	41371566	Silent	novel	S296S	0.24
UCEC	chr15	41377245	Missense_Mutation	NA	Q391H	0.23
UCEC	chr15	41332915	5'UTR	novel		0.46

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.2333	0.079424
CESC	DEL	0.2	0.00049652
COAD	DEL	0.3548	2.3878e-07
GBM	DEL	0.2184	3.453e-12
HNSC	DEL	0.1724	0.11567
KICH	AMP	0.2727	0.21756
KIRP	DEL	0.1076	0.2062
LUAD	DEL	0.3953	6.8561e-07
MESO	DEL	0.3103	4.5411e-10
PAAD	DEL	0.1304	0.13216
READ	DEL	0.4424	0.025797
SARC	DEL	0.2023	0.18974
STAD	DEL	0.195	3.2335e-05
UCEC	DEL	0.2393	7.1012e-08

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0035	Kaplan-Meier Survival Analysis
KIRC	0.0058	Kaplan-Meier Survival Analysis
STAD	0.046	Kaplan-Meier Survival Analysis
SARC	0.0056	Kaplan-Meier Survival Analysis
MESO	0.0001	Kaplan-Meier Survival Analysis
ACC	0.00028	Kaplan-Meier Survival Analysis
PRAD	0.033	Kaplan-Meier Survival Analysis
LUSC	0.036	Kaplan-Meier Survival Analysis
KIRP	0.00021	Kaplan-Meier Survival Analysis
PAAD	0.00019	Kaplan-Meier Survival Analysis
PCPG	0.039	Kaplan-Meier Survival Analysis
CESC	0.019	Kaplan-Meier Survival Analysis
KICH	0.016	Kaplan-Meier Survival Analysis
LIHC	0.0013	Kaplan-Meier Survival Analysis
LUAD	0.00011	Kaplan-Meier Survival Analysis
UVM	0.012	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000137804 (Gene tree)
Gene ID: 51203
Gene Symbol: NUSAP1
Alias: FLJ13421|LNP|ANKT|NuSAP1|SAPL|BM037|PRO0310p1|Q0310
Full Name: nucleolar and spindle associated protein 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 48,357 bases
Position: chr15:41,332,694-41,381,050
Accession: 18538
RBP type: non-canonical RBP
Summary: NUSAP1 is a nucleolar-spindle-associated protein that plays a role in spindle microtubule organization (Raemaekers et al., 2003 [PubMed 12963707]).[supplied by OMIM, Jun 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000559659	NUSAP1-209	529	-	-	- (aa)	-	-
ENST00000558582	NUSAP1-206	546	-	-	- (aa)	-	-
ENST00000559596	NUSAP1-208	1629	XM_006720559	ENSP00000453403	441 (aa)	XP_006720622	Q9BXS6
ENST00000560177	NUSAP1-210	2232	XM_006720560	ENSP00000453657	440 (aa)	XP_006720623	Q9BXS6
ENST00000560747	NUSAP1-212	2256	-	ENSP00000454097	439 (aa)	-	Q9BXS6
ENST00000450592	NUSAP1-203	1301	-	ENSP00000401014	378 (aa)	-	Q9BXS6
ENST00000414849	NUSAP1-202	2274	XM_005254428	ENSP00000400746	440 (aa)	XP_005254485	Q9BXS6
ENST00000558123	NUSAP1-205	1934	-	-	- (aa)	-	-
ENST00000557840	NUSAP1-204	416	-	ENSP00000453428	68 (aa)	-	H0YM18
ENST00000260359	NUSAP1-201	2409	XM_005254430	ENSP00000260359	426 (aa)	XP_005254487	Q9BXS6
ENST00000559046	NUSAP1-207	580	-	ENSP00000452725	76 (aa)	-	H0YKA7
ENST00000560318	NUSAP1-211	485	-	-	- (aa)	-	-
ENST00000560898	NUSAP1-213	708	-	ENSP00000453558	144 (aa)	-	H0YMD2

Gene Model

Click here to download ENSG00000137804's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000137804	Platelet Function Tests	6.5400000E-006	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000137804's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000137804	NUSAP1	94	60.798	ENSMUSG00000027306	Nusap1	99	61.384	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000070	mitotic sister chromatid segregation	12963707.	IDA	Process
GO:0000281	mitotic cytokinesis	21873635.	IBA	Process
GO:0000281	mitotic cytokinesis	12963707.	IDA	Process
GO:0003677	DNA binding	-	IEA	Function
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005694	chromosome	-	IEA	Component
GO:0005730	nucleolus	21873635.	IBA	Component
GO:0005737	cytoplasm	-	IEA	Component
GO:0005876	spindle microtubule	21873635.	IBA	Component
GO:0007076	mitotic chromosome condensation	21873635.	IBA	Process
GO:0007076	mitotic chromosome condensation	12963707.	IDA	Process
GO:0008017	microtubule binding	21873635.	IBA	Function
GO:0040001	establishment of mitotic spindle localization	21873635.	IBA	Process
GO:0040001	establishment of mitotic spindle localization	12963707.	IDA	Process
GO:0045840	positive regulation of mitotic nuclear division	12963707.	IDA	Process
GO:0072686	mitotic spindle	21873635.	IBA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.