EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26775597	Overexpression of KIF23 predicts clinical outcome in primary lung cancer patients.	Lung Cancer	2016 Feb	Kato T	doi: 10.1016/j.lungcan.2015.11.018

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr15	69429178	Missense_Mutation	novel	R346Q	0.22
BLCA	chr15	69444799	Nonsense_Mutation	novel	Q797*	0.29
BLCA	chr15	69444887	Missense_Mutation	NA	S826F	0.43
BLCA	chr15	69436184	Missense_Mutation	novel	R440T	0.24
BLCA	chr15	69436638	Missense_Mutation	novel	E491Q	0.31
BLCA	chr15	69429189	Missense_Mutation	NA	E350K	0.42
BLCA	chr15	69444859	Missense_Mutation	NA	D817N	0.17
BLCA	chr15	69436146	Missense_Mutation	rs149564859	M427I	0.25
BLCA	chr15	69422005	Silent	rs766423729	T110T	0.37
BLCA	chr15	69440433	Silent	novel	R671R	0.54
BLCA	chr15	69426167	Missense_Mutation	rs763331945	E278Q	0.17
BLCA	chr15	69417504	Missense_Mutation	rs187707408	Y68C	0.3
BLCA	chr15	69440812	Silent	novel	L704L	0.4
BLCA	chr15	69429189	Missense_Mutation	NA	E350K	0.75
BLCA	chr15	69440404	Missense_Mutation	novel	K662E	0.59
BRCA	chr15	69423187	Missense_Mutation	NA	M198V	0.31
BRCA	chr15	69440886	Missense_Mutation	NA	W729S	0.27
BRCA	chr15	69415991	Splice_Region	novel		0.64
BRCA	chr15	69438395	Frame_Shift_Del	novel	E569*	0.23
BRCA	chr15	69426334	Splice_Site	novel	X283_splice	0.09
BRCA	chr15	69445041	Missense_Mutation	NA	K877N	0.09
BRCA	chr15	69439950	Missense_Mutation	rs771100209	R587H	0.28
CESC	chr15	69439909	Silent	NA	E573E	0.35
CESC	chr15	69425297	Intron	novel		0.23
CESC	chr15	69421680	Missense_Mutation	NA	H82Y	0.14
CESC	chr15	69448042	3'UTR	novel		0.23
CESC	chr15	69438354	Missense_Mutation	NA	Q554H	0.11
CESC	chr15	69426155	Missense_Mutation	NA	E274K	0.2
CESC	chr15	69422405	Missense_Mutation	novel	A178V	0.49
CESC	chr15	69435508	Silent	rs556904790	T366T	0.32
CESC	chr15	69444883	Missense_Mutation	NA	A825T	0.32
CESC	chr15	69414412	5'UTR	novel		0.55
COAD	chr15	69447826	3'UTR	novel		0.03
COAD	chr15	69423190	Missense_Mutation	novel	I199V	0.07
COAD	chr15	69447830	3'UTR	novel		0.08
COAD	chr15	69445043	Splice_Site	novel	X877_splice	0.4
COAD	chr15	69435729	Frame_Shift_Ins	NA	N414*	0.3
COAD	chr15	69444848	Missense_Mutation	rs191196584	R813H	0.39
COAD	chr15	69444826	Missense_Mutation	NA	R806C	0.46
COAD	chr15	69440850	Missense_Mutation	NA	C717Y	0.47
COAD	chr15	69440313	Silent	NA	R631R	0.26
COAD	chr15	69436673	Silent	NA	E502E	0.16
COAD	chr15	69426168	Missense_Mutation	NA	E278A	0.21
GBM	chr15	69436634	Silent	novel	N489N	0.4
GBM	chr15	69417475	Silent	novel	E58E	0.04
GBM	chr15	69422386	Missense_Mutation	novel	E172K	0.48
HNSC	chr15	69440838	Missense_Mutation	rs370717019	R713H	0.39
HNSC	chr15	69426425	Missense_Mutation	novel	P313S	0.18
HNSC	chr15	69435690	Missense_Mutation	novel	F397L	0.29
HNSC	chr15	69436716	Missense_Mutation	novel	K517E	0.79
HNSC	chr15	69446868	Splice_Region	novel		0.13
HNSC	chr15	69440438	Missense_Mutation	NA	R673Q	0.13
HNSC	chr15	69441023	Missense_Mutation	novel	E775Q	0.1
HNSC	chr15	69446886	Missense_Mutation	novel	E938K	0.16
HNSC	chr15	69421733	Silent	rs370109100	D99D	0.1
HNSC	chr15	69446942	Splice_Site	novel	X956_splice	0.16
KIRC	chr15	69446048	Frame_Shift_Ins	novel	*Q891Lfs7**	0.04
KIRC	chr15	69446050	Missense_Mutation	novel	Q891H	0.03
LAML	chr15	69423178	Missense_Mutation	novel	F195V	0.07
LGG	chr15	69439936	Silent	novel	Y582Y	0.28
LGG	chr15	69435507	Missense_Mutation	rs377663038	T366M	0.21
LGG	chr15	69422012	Missense_Mutation	NA	V113M	0.1
LUAD	chr15	69444901	Missense_Mutation	NA	E831K	0.31
LUAD	chr15	69429178	Missense_Mutation	novel	R346Q	0.11
LUAD	chr15	69441046	Frame_Shift_Ins	novel	*E783Tfs19**	0.08
LUAD	chr15	69444848	Missense_Mutation	novel	R813L	0.24
LUAD	chr15	69417458	Missense_Mutation	NA	Q53K	0.32
LUAD	chr15	69429146	Missense_Mutation	NA	L335F	0.24
LUSC	chr15	69439994	Nonsense_Mutation	novel	R602*	0.68
LUSC	chr15	69422361	Missense_Mutation	novel	I163M	0.21
LUSC	chr15	69447823	3'UTR	novel		0.55
LUSC	chr15	69422039	Missense_Mutation	rs200683749	M122V	0.2
LUSC	chr15	69417397	Silent	NA	V32V	0.25
LUSC	chr15	69440959	Silent	novel	P753P	0.11
LUSC	chr15	69446893	Missense_Mutation	novel	R940T	0.18
LUSC	chr15	69423202	Missense_Mutation	NA	E203Q	0.36
LUSC	chr15	69422103	Frame_Shift_Del	novel	*G144Ifs4**	0.24
OV	chr15	69447989	3'UTR	novel		0.26
PAAD	chr15	69426411	Missense_Mutation	novel	K308T	0.21
PAAD	chr15	69438389	Missense_Mutation	novel	K566T	0.04
PRAD	chr15	69436208	Missense_Mutation	rs776179725	G448D	0.4
READ	chr15	69414384	5'UTR	novel		0.17
READ	chr15	69426145	Silent	novel	V270V	0.38
READ	chr15	69444826	Missense_Mutation	NA	R806C	0.17
SARC	chr15	69448240	3'UTR	novel		0.19
SARC	chr15	69440438	Missense_Mutation	NA	R673Q	0.28
SKCM	chr15	69440900	Missense_Mutation	rs559197892	P734S	0.53
SKCM	chr15	69447839	3'UTR	novel		0.4
SKCM	chr15	69435529	Silent	NA	V373V	0.46
SKCM	chr15	69444845	Missense_Mutation	NA	S812L	0.1
SKCM	chr15	69440000	Missense_Mutation	NA	F604L	0.21
SKCM	chr15	69438362	Missense_Mutation	NA	E557A	0.26
SKCM	chr15	69440473	Missense_Mutation	NA	P685S	0.29
SKCM	chr15	69440431	Missense_Mutation	rs377162847	R671W	0.49
SKCM	chr15	69422416	Missense_Mutation	novel	P182S	0.19
SKCM	chr15	69435729	Silent	rs751960615	I410I	0.44
SKCM	chr15	69426381	Missense_Mutation	novel	S298F	0.33
SKCM	chr15	69440796	Missense_Mutation	rs548372407	S699F	0.09
STAD	chr15	69435727	Missense_Mutation	NA	I410V	0.26
STAD	chr15	69416025	Frame_Shift_Del	novel	*S18Pfs27**	0.26
STAD	chr15	69417459	Missense_Mutation	NA	Q53R	0.47
STAD	chr15	69440312	Missense_Mutation	NA	R631H	0.23
STAD	chr15	69440942	Missense_Mutation	rs747635090	R748C	0.49
STAD	chr15	69440979	Missense_Mutation	novel	I760S	0.1
STAD	chr15	69435664	Nonsense_Mutation	NA	R389*	0.22
STAD	chr15	69436580	Silent	rs747697382	D471D	0.24
STAD	chr15	69444827	Missense_Mutation	rs763116733	R806H	0.25
STAD	chr15	69447857	3'UTR	novel		0.28
STAD	chr15	69440438	Missense_Mutation	NA	R673Q	0.19
STAD	chr15	69436616	Silent	NA	C483C	0.21
THCA	chr15	69426124	Silent	novel	A263A	0.08
THCA	chr15	69416010	Missense_Mutation	rs773977730	R10W	0.15
UCEC	chr15	69444832	Nonsense_Mutation	NA	R808*	0.35
UCEC	chr15	69422124	Missense_Mutation	NA	R150L	0.32
UCEC	chr15	69423162	Silent	novel	R189R	0.47
UCEC	chr15	69426370	Missense_Mutation	NA	L294F	0.36
UCEC	chr15	69422027	Missense_Mutation	novel	K118Q	0.08
UCEC	chr15	69444899	Missense_Mutation	novel	T830I	0.3
UCEC	chr15	69421673	Silent	novel	F79F	0.43
UCEC	chr15	69440850	Missense_Mutation	NA	C717Y	0.32
UCEC	chr15	69422017	Silent	rs544467574	T114T	0.4
UCEC	chr15	69444849	Silent	novel	R813R	0.38
UCEC	chr15	69421740	Missense_Mutation	novel	H102N	0.29
UCEC	chr15	69422124	Missense_Mutation	NA	R150Q	0.21
UCEC	chr15	69447931	3'UTR	novel		0.07
UCEC	chr15	69440053	Silent	NA	T621T	0.17
UCEC	chr15	69426397	Silent	novel	S303S	0.17
UCEC	chr15	69440311	Missense_Mutation	novel	R631S	0.13
UCEC	chr15	69414416	5'UTR	novel		0.25
UCEC	chr15	69444882	Silent	rs200472874	P824P	0.5
UCEC	chr15	69448121	3'UTR	novel		0.3
UCEC	chr15	69440854	Silent	novel	S718S	0.27
UCEC	chr15	69435729	Silent	rs751960615	I410I	0.57
UCEC	chr15	69435704	Missense_Mutation	novel	D402G	0.36
UCEC	chr15	69417492	Missense_Mutation	rs757158186	R64Q	0.37
UCEC	chr15	69436707	Missense_Mutation	NA	E514K	0.1
UCEC	chr15	69446931	Missense_Mutation	novel	A953T	0.57
UCEC	chr15	69448141	3'UTR	novel		0.36
UCEC	chr15	69422124	Missense_Mutation	NA	R150Q	0.3
UCEC	chr15	69439995	Missense_Mutation	rs560577725	R602Q	0.11
UCEC	chr15	69440937	Missense_Mutation	novel	A746V	0.23
UCEC	chr15	69448247	3'UTR	novel		0.07
UCEC	chr15	69446896	Missense_Mutation	NA	A941V	0.29
UCEC	chr15	69447857	3'UTR	novel		0.46
UCEC	chr15	69426092	Missense_Mutation	novel	R253C	0.26
UCEC	chr15	69447793	Missense_Mutation	novel	R957C	0.42
UCEC	chr15	69440980	Silent	rs760870759	I760I	0.11
UCEC	chr15	69417492	Missense_Mutation	rs757158186	R64Q	0.38
UCEC	chr15	69438261	Missense_Mutation	NA	K523N	0.29
UCEC	chr15	69446931	Missense_Mutation	novel	A953T	0.17
UCEC	chr15	69440379	Silent	novel	Q653Q	0.28
UCEC	chr15	69448132	3'UTR	novel		0.12
UCEC	chr15	69447932	3'UTR	novel		0.06
UCEC	chr15	69429131	Missense_Mutation	novel	I330M	0.26
UCEC	chr15	69426351	Missense_Mutation	rs756964640	R288H	0.36
UCEC	chr15	69422124	Missense_Mutation	NA	R150Q	0.47
UCEC	chr15	69426350	Missense_Mutation	novel	R288C	0.48
UCEC	chr15	69438245	Splice_Region	novel		0.32
UCEC	chr15	69417508	Silent	novel	K69K	0.17
UCEC	chr15	69422123	Nonsense_Mutation	novel	R150*	0.17
UCEC	chr15	69435524	Missense_Mutation	novel	D372Y	0.2
UCEC	chr15	69446288	Missense_Mutation	rs550720473	R907Q	0.17
UCEC	chr15	69417399	Missense_Mutation	NA	R33H	0.21
UCEC	chr15	69436629	Missense_Mutation	novel	I488F	0.39
UCEC	chr15	69435732	Silent	novel	V411V	0.26
UCEC	chr15	69429204	Missense_Mutation	rs776621961	R355C	0.24
UCEC	chr15	69435769	Missense_Mutation	novel	L424V	0.43
UCEC	chr15	69439958	Nonsense_Mutation	novel	Q590*	0.14
UCEC	chr15	69444807	Missense_Mutation	novel	D799E	0.38
UCS	chr15	69423160	Nonsense_Mutation	novel	R189*	0.24

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
LGG	AMP	0.0175	0.19963
PAAD	AMP	0.0652	0.20695
PAAD	DEL	0.1087	0.13216

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0023	Kaplan-Meier Survival Analysis
STAD	0.034	Kaplan-Meier Survival Analysis
SARC	0.021	Kaplan-Meier Survival Analysis
ACC	0.00011	Kaplan-Meier Survival Analysis
SKCM	0.019	Kaplan-Meier Survival Analysis
PRAD	0.04	Kaplan-Meier Survival Analysis
KIRP	0.0001	Kaplan-Meier Survival Analysis
PAAD	0.0001	Kaplan-Meier Survival Analysis
PCPG	0.029	Kaplan-Meier Survival Analysis
READ	0.029	Kaplan-Meier Survival Analysis
KICH	0.00079	Kaplan-Meier Survival Analysis
UCEC	0.00053	Kaplan-Meier Survival Analysis
LIHC	0.00012	Kaplan-Meier Survival Analysis
CHOL	0.0036	Kaplan-Meier Survival Analysis
LUAD	0.0001	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000137807 (Gene tree)
Gene ID: 9493
Gene Symbol: KIF23
Alias: MKLP1|MKLP-1|KNSL5
Full Name: kinesin family member 23
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 34,182 bases
Position: chr15:69,414,246-69,448,427
Accession: 6392
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
30195762	LncRNA UCA1, Upregulated in CRC Biopsies and Downregulated in Serum Exosomes, Controls mRNA Expression by RNA-RNA Interactions.	Mol Ther Nucleic Acids	2018 Sep 7	Barbagallo C	doi: 10.1016/j.omtn.2018.05.009

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000558585	KIF23-206	2296	-	-	- (aa)	-	-
ENST00000643966	KIF23-214	3446	-	ENSP00000494167	283 (aa)	-	A0A2R8Y531
ENST00000560125	KIF23-212	532	-	-	- (aa)	-	-
ENST00000558303	KIF23-204	1766	-	-	- (aa)	-	-
ENST00000352331	KIF23-202	3351	-	ENSP00000304978	856 (aa)	-	Q02241
ENST00000559279	KIF23-207	3129	XM_005254799	ENSP00000453386	810 (aa)	XP_005254856	A0A2U3TZL8
ENST00000559283	KIF23-208	1081	-	-	- (aa)	-	-
ENST00000558346	KIF23-205	1656	-	ENSP00000453576	371 (aa)	-	H0YME6
ENST00000561089	KIF23-213	2743	-	ENSP00000453629	109 (aa)	-	H0YMJ4
ENST00000260363	KIF23-201	3723	XM_011522239	ENSP00000260363	960 (aa)	XP_011520541	Q02241
ENST00000395392	KIF23-203	3357	-	ENSP00000378790	952 (aa)	-	H7BYN4
ENST00000559456	KIF23-209	1282	-	-	- (aa)	-	-
ENST00000560042	KIF23-211	565	-	-	- (aa)	-	-
ENST00000647715	KIF23-215	3620	XM_005254796	ENSP00000497065	960 (aa)	XP_005254853	UPI0000072141
ENST00000559944	KIF23-210	674	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000137807's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa05206	MicroRNAs in cancer	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000137807's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000022	mitotic spindle elongation	1406973.	TAS	Process
GO:0000281	mitotic cytokinesis	15843429.16236794.	IMP	Process
GO:0000915	actomyosin contractile ring assembly	-	IEA	Process
GO:0003777	microtubule motor activity	21873635.	IBA	Function
GO:0005515	protein binding	11782313.14676191.15161933.15197175.16236794.16431929.18201571.18329369.19468300.20451386.22522702.22580824.22750944.26496610.27528609.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	11782313.15197175.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005813	centrosome	20186884.	IDA	Component
GO:0005819	spindle	15197175.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005871	kinesin complex	21873635.	IBA	Component
GO:0005874	microtubule	21873635.	IBA	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	-	TAS	Process
GO:0007018	microtubule-based movement	21873635.	IBA	Process
GO:0007018	microtubule-based movement	-	TAS	Process
GO:0008017	microtubule binding	21873635.	IBA	Function
GO:0008017	microtubule binding	11782313.	IDA	Function
GO:0016887	ATPase activity	21873635.	IBA	Function
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	-	TAS	Process
GO:0030496	midbody	11782313.15197175.15843429.20186884.	IDA	Component
GO:0032467	positive regulation of cytokinesis	16103226.	IMP	Process
GO:0045171	intercellular bridge	-	IEA	Component
GO:0051256	mitotic spindle midzone assembly	21873635.	IBA	Process
GO:0051256	mitotic spindle midzone assembly	16103226.	IMP	Process
GO:0072383	plus-end-directed vesicle transport along microtubule	-	IEA	Process
GO:0072686	mitotic spindle	16236794.	IDA	Component
GO:0090543	Flemming body	-	IEA	Component
GO:0097149	centralspindlin complex	11782313.16236794.	IDA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.