EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
29848298	IFI44L is a novel tumor suppressor in human hepatocellular carcinoma affecting cancer stemness, metastasis, and drug resistance via regulating met/Src signaling pathway.	BMC Cancer	2018 May 30	Huang WC	doi: 10.1186/s12885-018-4529-9.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr1	78637154	Frame_Shift_Ins	novel	*M335Nfs25**	0.31	MMR_HSR1
BLCA	chr1	78641783	Missense_Mutation	NA	E445K	0.28
BLCA	chr1	78635350	Missense_Mutation	novel	S246F	0.29	MMR_HSR1
BLCA	chr1	78635358	Missense_Mutation	NA	D249Y	0.46	MMR_HSR1
BLCA	chr1	78641082	Frame_Shift_Ins	novel	*L372Ffs5**	0.43
BLCA	chr1	78637089	Missense_Mutation	NA	L312V	0.18	MMR_HSR1
BLCA	chr1	78627987	Missense_Mutation	NA	L24F	0.56
BRCA	chr1	78641498	Missense_Mutation	NA	A405P	0.17
BRCA	chr1	78635417	Silent	novel	G268G	0.05
BRCA	chr1	78628177	Frame_Shift_Ins	novel	*Q88Lfs21**	0.18
CESC	chr1	78628359	Silent	novel	R148R	0.53
CESC	chr1	78641074	Nonsense_Mutation	NA	Q368*	0.13
COAD	chr1	78637061	Silent	NA	E302E	0.17
COAD	chr1	78635372	Silent	NA	G253G	0.23
COAD	chr1	78627962	Missense_Mutation	rs768684222	R16H	0.57
COAD	chr1	78641588	Missense_Mutation	NA	D435Y	0.23
COAD	chr1	78637131	Missense_Mutation	NA	N326D	0.25	MMR_HSR1
COAD	chr1	78629878	Missense_Mutation	rs761494321	A229D	0.1	MMR_HSR1
COAD	chr1	78641791	Silent	rs200301854	A447A	0.1
COAD	chr1	78628259	Missense_Mutation	NA	R115H	0.36
COAD	chr1	78637061	Silent	NA	E302E	0.12
COAD	chr1	78641952	3'UTR	novel		0.37
COAD	chr1	78628292	Missense_Mutation	rs546691087	R126Q	0.48
COAD	chr1	78641064	Silent	novel	S364S	0.19
ESCA	chr1	78628157	Missense_Mutation	rs75343387	D81V	0.27
ESCA	chr1	78641808	Nonstop_Mutation	novel	453Lext5	0.35
ESCA	chr1	78641533	Silent	novel	I416I	0.08
ESCA	chr1	78629850	Missense_Mutation	rs770941163	I220V	0.35	MMR_HSR1
GBM	chr1	78628970	Silent	NA	D166D	0.42
GBM	chr1	78628266	Silent	rs200570011	S117S	0.29
GBM	chr1	78641046	Silent	novel	T358T	0.15
GBM	chr1	78641849	3'UTR	novel		0.39
GBM	chr1	78629718	Splice_Site	novel	X176_splice	0.09
GBM	chr1	78628343	Missense_Mutation	novel	R143M	0.08
GBM	chr1	78635398	In_Frame_Del	novel	T263_Y291del	0.06	MMR_HSR1
HNSC	chr1	78629827	Frame_Shift_Ins	novel	*N215Qfs20**	0.24	MMR_HSR1
HNSC	chr1	78641808	Nonstop_Mutation	novel	453Sext5	0.35
HNSC	chr1	78628312	Missense_Mutation	novel	D133Y	0.28
HNSC	chr1	78641071	Missense_Mutation	novel	L367I	0.67
HNSC	chr1	78628052	Missense_Mutation	rs149202070	R46H	0.35
HNSC	chr1	78628260	Silent	rs756432982	R115R	0.29
KIRC	chr1	78635481	In_Frame_Del	novel	R290_Q292del	0.11	MMR_HSR1
KIRC	chr1	78629897	Nonsense_Mutation	novel	*T236Cfs2**	0.04	MMR_HSR1
LGG	chr1	78629838	Missense_Mutation	novel	S216T	0.08	MMR_HSR1
LGG	chr1	78629839	Nonsense_Mutation	novel	V217*	0.08	MMR_HSR1
LIHC	chr1	78637111	Missense_Mutation	novel	V319A	0.25	MMR_HSR1
LIHC	chr1	78641450	Missense_Mutation	novel	K389E	0.05
LIHC	chr1	78629771	Missense_Mutation	novel	D193E	0.42
LUAD	chr1	78641510	Missense_Mutation	novel	E409Q	0.11
LUAD	chr1	78641600	Missense_Mutation	NA	E439Q	0.1
LUAD	chr1	78637076	Silent	NA	I307I	0.16
LUAD	chr1	78635431	Missense_Mutation	novel	G273A	0.35	MMR_HSR1
LUAD	chr1	78628052	Missense_Mutation	novel	R46L	0.06
LUAD	chr1	78635381	Silent	novel	L256L	0.15
LUAD	chr1	78641790	Missense_Mutation	NA	A447G	0.49
LUAD	chr1	78628981	Missense_Mutation	NA	R170M	0.55
LUAD	chr1	78637078	Frame_Shift_Del	novel	*S309Lfs4**	0.08	MMR_HSR1
LUAD	chr1	78628222	Missense_Mutation	novel	T103A	0.1
LUAD	chr1	78641510	Nonsense_Mutation	novel	E409*	0.38
LUAD	chr1	78627987	Missense_Mutation	novel	L24F	0.34
LUAD	chr1	78641520	Missense_Mutation	novel	P412H	0.33
LUAD	chr1	78628228	Frame_Shift_Del	novel	*P105Qfs28**	0.38
LUAD	chr1	78641025	Silent	novel	I351I	0.55
LUAD	chr1	78641878	3'UTR	novel		0.22
LUAD	chr1	78628950	Splice_Site	novel	X160_splice	0.36
LUAD	chr1	78628951	Missense_Mutation	novel	G160V	0.38
LUAD	chr1	78635336	Splice_Site	novel	X242_splice	0.19
LUAD	chr1	78641808	Nonstop_Mutation	novel	453Lext5	0.22
LUAD	chr1	78635439	Missense_Mutation	NA	M276L	0.06	MMR_HSR1
LUSC	chr1	78641492	Missense_Mutation	NA	N403Y	0.29
LUSC	chr1	78629844	Missense_Mutation	NA	K218Q	0.24	MMR_HSR1
LUSC	chr1	78628182	Silent	novel	K89K	0.32
LUSC	chr1	78641893	3'UTR	novel		0.36
LUSC	chr1	78635481	Nonsense_Mutation	NA	R290*	0.12	MMR_HSR1
LUSC	chr1	78635427	Missense_Mutation	rs575130272	A272T	0.4	MMR_HSR1
LUSC	chr1	78629748	Missense_Mutation	NA	R186G	0.15
LUSC	chr1	78641465	Missense_Mutation	NA	P394S	0.22
LUSC	chr1	78641594	Missense_Mutation	novel	P437S	0.69
LUSC	chr1	78641890	3'UTR	novel		0.28
LUSC	chr1	78627987	Missense_Mutation	NA	L24F	0.46
LUSC	chr1	78641585	Nonsense_Mutation	novel	E434*	0.09
MESO	chr1	78629769	Missense_Mutation	novel	D193N	0.56
OV	chr1	78628051	Missense_Mutation	NA	R46C	0.25
OV	chr1	78628970	Missense_Mutation	NA	D166E	0.12
OV	chr1	78641098	Frame_Shift_Del	novel	*R376Dfs3**	0.04
OV	chr1	78627962	Missense_Mutation	NA	R16P	0.28
PAAD	chr1	78628979	Missense_Mutation	novel	K169N	0.1
PAAD	chr1	78637120	Missense_Mutation	novel	V322D	0.24	MMR_HSR1
PAAD	chr1	78628160	Missense_Mutation	rs781138097	S82F	0.03
PRAD	chr1	78641824	3'UTR	novel		0.06
READ	chr1	78628051	Missense_Mutation	NA	R46C	0.12
READ	chr1	78627939	Silent	novel	T8T	0.3
READ	chr1	78635336	Splice_Site	novel	X242_splice	0.42
READ	chr1	78642077	3'UTR	novel		0.4
READ	chr1	78628971	Missense_Mutation	NA	D167N	0.29
SARC	chr1	78637166	Frame_Shift_Del	novel	V339*	0.51	MMR_HSR1
SARC	chr1	78637170	Missense_Mutation	novel	V339L	0.5	MMR_HSR1
SARC	chr1	78629822	Missense_Mutation	novel	K210N	0.11	MMR_HSR1
SKCM	chr1	78635398	Missense_Mutation	NA	D262V	0.25	MMR_HSR1
SKCM	chr1	78627955	Missense_Mutation	NA	H14Y	0.31
SKCM	chr1	78641918	3'UTR	novel		0.25
SKCM	chr1	78628111	Missense_Mutation	novel	L66F	0.18
SKCM	chr1	78628395	Splice_Site	novel	X160_splice	0.27
SKCM	chr1	78635442	Missense_Mutation	rs777051846	D277N	0.14	MMR_HSR1
SKCM	chr1	78628320	Missense_Mutation	NA	M135I	0.29
SKCM	chr1	78629875	Missense_Mutation	NA	Q228L	0.45	MMR_HSR1
SKCM	chr1	78628265	Missense_Mutation	rs370772828	S117L	0.86
SKCM	chr1	78635425	Missense_Mutation	NA	G271E	0.21	MMR_HSR1
SKCM	chr1	78628273	Missense_Mutation	rs777441989	D120N	0.25
STAD	chr1	78637174	Missense_Mutation	NA	K340R	0.39	MMR_HSR1
STAD	chr1	78629836	Missense_Mutation	novel	N215I	0.08	MMR_HSR1
STAD	chr1	78628168	Missense_Mutation	NA	F85L	0.11
STAD	chr1	78641976	3'UTR	novel		0.29
STAD	chr1	78641446	Silent	novel	V387V	0.43
STAD	chr1	78635362	Frame_Shift_Ins	novel	*N252Kfs11**	0.17	MMR_HSR1
STAD	chr1	78628254	Silent	NA	V113V	0.09
STAD	chr1	78635428	Missense_Mutation	novel	A272E	0.13	MMR_HSR1
STAD	chr1	78637108	Missense_Mutation	rs374146000	C318Y	0.15	MMR_HSR1
STAD	chr1	78629913	Missense_Mutation	rs780019224	R241W	0.26	MMR_HSR1
STAD	chr1	78641517	Missense_Mutation	NA	D411G	0.29
STAD	chr1	78627957	Missense_Mutation	NA	H14Q	0.25
STAD	chr1	78628388	Missense_Mutation	NA	V158A	0.09
STAD	chr1	78627961	Missense_Mutation	rs369648433	R16C	0.19
STAD	chr1	78629739	Missense_Mutation	NA	A183T	0.46
TGCT	chr1	78641818	3'UTR	novel		0.31
THCA	chr1	78629839	Missense_Mutation	novel	S216L	0.02	MMR_HSR1
UCEC	chr1	78628291	Nonsense_Mutation	rs770275936	R126*	0.1
UCEC	chr1	78628252	Missense_Mutation	novel	V113M	0.32
UCEC	chr1	78637099	Missense_Mutation	novel	R315M	0.2	MMR_HSR1
UCEC	chr1	78628204	Nonsense_Mutation	NA	E97*	0.36
UCEC	chr1	78629853	Missense_Mutation	novel	F221V	0.4	MMR_HSR1
UCEC	chr1	78628103	Missense_Mutation	novel	A63V	0.31
UCEC	chr1	78629787	Missense_Mutation	rs202037753	R199C	0.15	MMR_HSR1
UCEC	chr1	78628981	Missense_Mutation	NA	R170M	0.17
UCEC	chr1	78629822	Silent	rs139856302	K210K	0.17
UCEC	chr1	78628177	Frame_Shift_Ins	novel	*Q88Lfs21**	0.04
UCEC	chr1	78642041	3'UTR	novel		0.12
UCEC	chr1	78641941	3'UTR	novel		0.34
UCEC	chr1	78629768	Silent	NA	A192A	0.21
UCEC	chr1	78635358	Missense_Mutation	NA	D249Y	0.16	MMR_HSR1
UCEC	chr1	78641117	Missense_Mutation	NA	S382N	0.35
UCEC	chr1	78628118	Missense_Mutation	novel	N68T	0.4
UCEC	chr1	78629787	Missense_Mutation	rs202037753	R199C	0.42	MMR_HSR1
UCEC	chr1	78628356	Silent	novel	H147H	0.23
UCEC	chr1	78641876	3'UTR	novel		0.16
UCEC	chr1	78641551	Silent	NA	L422L	0.15
UCEC	chr1	78637159	Missense_Mutation	novel	M335R	0.14	MMR_HSR1
UCEC	chr1	78628266	Silent	rs200570011	S117S	0.17
UCEC	chr1	78627926	Missense_Mutation	novel	T4I	0.31
UCEC	chr1	78628322	Missense_Mutation	novel	I136T	0.38
UCEC	chr1	78628160	Missense_Mutation	novel	S82Y	0.31
UCEC	chr1	78641967	3'UTR	novel		0.53
UCEC	chr1	78628077	Frame_Shift_Del	novel	*I56Afs6**	0.29
UCEC	chr1	78629897	Silent	NA	I235I	0.3
UCEC	chr1	78629725	Missense_Mutation	novel	R178I	0.1
UCEC	chr1	78628230	Frame_Shift_Del	novel	*I107Lfs26**	0.41
UCEC	chr1	78628056	Missense_Mutation	NA	Q47H	0.26
UCEC	chr1	78635437	Missense_Mutation	novel	C275Y	0.35	MMR_HSR1
UCEC	chr1	78641020	Splice_Site	novel	X350_splice	0.18
UCEC	chr1	78641527	Missense_Mutation	novel	K414N	0.21
UCEC	chr1	78627929	Missense_Mutation	rs375524121	T5I	0.1
UCEC	chr1	78637201	Missense_Mutation	novel	C349Y	0.36
UCEC	chr1	78628236	Silent	novel	I107I	0.31
UCEC	chr1	78641588	Missense_Mutation	NA	D435Y	0.48
UCEC	chr1	78637036	Missense_Mutation	NA	N294T	0.42	MMR_HSR1
UCEC	chr1	78628266	Silent	rs200570011	S117S	0.41
UCEC	chr1	78629787	Missense_Mutation	rs202037753	R199C	0.08	MMR_HSR1
UCEC	chr1	78641102	Missense_Mutation	novel	S377F	0.24
UCEC	chr1	78641551	Silent	NA	L422L	0.28
UCEC	chr1	78641111	Missense_Mutation	novel	S380Y	0.35
UCEC	chr1	78628305	Silent	novel	I130I	0.37
UCEC	chr1	78628052	Missense_Mutation	rs149202070	R46H	0.3
UCEC	chr1	78635379	Missense_Mutation	novel	L256M	0.23	MMR_HSR1

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
COAD	DEL	0.2461	0.00038973
STAD	DEL	0.1565	0.0040659
TGCT	AMP	0.1533	0.088103

Survival Analysis

Cancer	P-value	Q-value
SKCM	0.00012	Kaplan-Meier Survival Analysis
TGCT	0.026	Kaplan-Meier Survival Analysis
KIRP	0.016	Kaplan-Meier Survival Analysis
PAAD	0.00089	Kaplan-Meier Survival Analysis
UCEC	0.01	Kaplan-Meier Survival Analysis
GBM	0.0059	Kaplan-Meier Survival Analysis
LGG	0.00053	Kaplan-Meier Survival Analysis
UVM	0.016	Kaplan-Meier Survival Analysis
OV	0.0096	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000137959 (Gene tree)
Gene ID: 10964
Gene Symbol: IFI44L
Alias: GS3686|C1orf29
Full Name: interferon induced protein 44 like
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 26,224 bases
Position: chr1:78,619,922-78,646,145
Accession: 17817
RBP type: canonical RBP
Summary: IFI44L (Interferon Induced Protein 44 Like) is a Protein Coding gene. An important paralog of this gene is IFI44.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000359787	MMR_HSR1	PF01926.23	0.00025	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000370751	IFI44L-201	5874	XM_005270391	ENSP00000359787	452 (aa)	XP_005270448	Q53G44
ENST00000450498	IFI44L-202	849	-	ENSP00000400784	232 (aa)	-	H7C1K6
ENST00000462041	IFI44L-205	565	-	-	- (aa)	-	-
ENST00000476876	IFI44L-208	890	-	-	- (aa)	-	-
ENST00000486882	IFI44L-209	5152	-	-	- (aa)	-	-
ENST00000494910	IFI44L-210	664	-	-	- (aa)	-	-
ENST00000452835	IFI44L-203	554	-	ENSP00000409914	97 (aa)	-	C9JPJ0
ENST00000474002	IFI44L-206	928	-	-	- (aa)	-	-
ENST00000476521	IFI44L-207	1162	-	-	- (aa)	-	-
ENST00000459784	IFI44L-204	745	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000137959's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000137959	Seizures, Febrile	1E-9	25344690
ENSG00000137959	Seizures, Febrile	6E-12	25344690

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000137959	rs273259	1	78628133	A	Febrile seizures	25344690	[1.27-1.59]	1.42	HP_0002373\|EFO_0006519
ENSG00000137959	rs273259	1	78628133	A	Febrile seizures (MMR vaccine-related)	25344690	[1.28-1.55]	1.41	EFO_0006519
ENSG00000137959	rs1333973	1	78628396	A	Immune response to measles vaccine (measles-specific neutralising antibody titre)	28289848			EFO_0004645
ENSG00000137959	rs1333973	1	78628396	A	Immune response to measles vaccine (measles-specific neutralising antibody titre)	28289848			EFO_0004645

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000137959's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000137959	IFI44L	99	82.040	ENSANAG00000025193	IFI44L	99	82.040	Aotus_nancymaae
ENSG00000137959	IFI44L	100	80.353	ENSCCAG00000034830	IFI44L	100	80.353	Cebus_capucinus
ENSG00000137959	IFI44L	100	91.753	ENSCATG00000030541	IFI44L	100	89.381	Cercocebus_atys
ENSG00000137959	IFI44L	100	91.753	ENSCSAG00000001407	IFI44L	100	88.496	Chlorocebus_sabaeus
ENSG00000137959	IFI44L	100	90.722	ENSCANG00000032603	IFI44L	100	89.602	Colobus_angolensis_palliatus
ENSG00000137959	IFI44L	97	61.435	ENSLAFG00000018293	IFI44L	100	61.435	Loxodonta_africana
ENSG00000137959	IFI44L	100	91.753	ENSMFAG00000035946	IFI44L	100	89.823	Macaca_fascicularis
ENSG00000137959	IFI44L	100	91.753	ENSMMUG00000001569	IFI44L	100	89.602	Macaca_mulatta
ENSG00000137959	IFI44L	100	91.753	ENSMNEG00000010138	IFI44L	100	90.044	Macaca_nemestrina
ENSG00000137959	IFI44L	100	90.722	ENSMLEG00000025798	IFI44L	100	89.381	Mandrillus_leucophaeus
ENSG00000137959	IFI44L	98	60.090	ENSOCUG00000024378	IFI44L	99	60.090	Oryctolagus_cuniculus
ENSG00000137959	IFI44L	100	91.753	ENSPANG00000009471	IFI44L	100	89.602	Papio_anubis
ENSG00000137959	IFI44L	100	95.876	ENSPPYG00000001215	IFI44L	100	93.805	Pongo_abelii
ENSG00000137959	IFI44L	98	54.402	ENSRNOG00000049994	Ifi44l	99	54.402	Rattus_norvegicus
ENSG00000137959	IFI44L	100	90.722	ENSRBIG00000028526	IFI44L	100	90.044	Rhinopithecus_bieti
ENSG00000137959	IFI44L	100	90.722	ENSRROG00000036097	IFI44L	100	90.265	Rhinopithecus_roxellana

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003674	molecular_function	-	ND	Function
GO:0005525	GTP binding	-	IEA	Function
GO:0005575	cellular_component	-	ND	Component
GO:0005737	cytoplasm	-	IEA	Component
GO:0006955	immune response	21873635.	IBA	Process
GO:0051607	defense response to virus	21478870.	IDA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.