EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
19580345	Acute lymphoblastic leukemia-derived dendritic cells express tumor associated antigens: PNPT1, PMPCB, RHAMM, BSG and ERCC1.	Neoplasma	2009	Luczynski W	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr2	55680882	Missense_Mutation	novel	E164K	0.36
BLCA	chr2	55693772	Missense_Mutation	novel	D18N	0.24
BLCA	chr2	55693724	Missense_Mutation	novel	Q34K	0.33
BLCA	chr2	55656140	Missense_Mutation	rs146990953	E478Q	0.08
BLCA	chr2	55654899	Splice_Site	NA	X499_splice	0.28
BLCA	chr2	55671334	Missense_Mutation	novel	E321K	0.42
BLCA	chr2	55672990	Missense_Mutation	NA	Q257K	0.14
BLCA	chr2	55643160	Splice_Region	novel	I689I	0.08
BLCA	chr2	55636354	Missense_Mutation	novel	M745I	0.33
BLCA	chr2	55647376	Missense_Mutation	novel	E525K	0.21
BRCA	chr2	55643387	Missense_Mutation	NA	V649I	0.31
BRCA	chr2	55640631	Missense_Mutation	rs765249456	R715Q	0.1
BRCA	chr2	55693808	Missense_Mutation	novel	Y6D	0.25
BRCA	chr2	55686432	Missense_Mutation	NA	A79T	0.28
BRCA	chr2	55667019	Missense_Mutation	rs757766273	S383L	0.13
BRCA	chr2	55672920	Missense_Mutation	rs143022417	S280L	0.27
CESC	chr2	55679739	Nonsense_Mutation	NA	E208*	0.42	KH_1
CESC	chr2	55645382	Nonsense_Mutation	NA	R597*	0.49
CESC	chr2	55679765	Missense_Mutation	novel	E199G	0.47	KH_1
CESC	chr2	55636132	3'UTR	novel		0.43
CESC	chr2	55647414	Missense_Mutation	novel	G512A	0.22
COAD	chr2	55679787	Nonsense_Mutation	NA	R192*	0.32	KH_1
COAD	chr2	55693715	Missense_Mutation	NA	A37S	0.38
COAD	chr2	55646289	Frame_Shift_Del	novel	*I570Lfs2**	0.2
COAD	chr2	55636343	Missense_Mutation	NA	R749Q	0.25
COAD	chr2	55687661	Missense_Mutation	novel	G69D	0.33
COAD	chr2	55640663	Silent	rs145069656	A704A	0.41
COAD	chr2	55646279	Missense_Mutation	NA	E573G	0.18
COAD	chr2	55673062	Missense_Mutation	NA	A233T	0.37	KH_1
COAD	chr2	55679777	Missense_Mutation	NA	I195K	0.47	KH_1
COAD	chr2	55671336	Missense_Mutation	rs200555807	T320M	0.26
COAD	chr2	55693864	5'Flank	rs531376073		0.1
COAD	chr2	55667028	Missense_Mutation	novel	L380P	0.04
ESCA	chr2	55684951	Missense_Mutation	novel	R132Q	0.5
GBM	chr2	55646298	Missense_Mutation	NA	P567S	0.09
GBM	chr2	55686424	Missense_Mutation	novel	M81I	0.23
GBM	chr2	55647347	Missense_Mutation	NA	L534F	0.32
HNSC	chr2	55672952	Silent	novel	T269T	0.19
HNSC	chr2	55687649	Missense_Mutation	novel	V73A	0.16
HNSC	chr2	55693808	Missense_Mutation	novel	Y6H	0.17
HNSC	chr2	55672939	Nonsense_Mutation	novel	Q274*	0.23
HNSC	chr2	55646280	Missense_Mutation	novel	E573Q	0.18
KIRP	chr2	55643363	Missense_Mutation	rs766570634	M657V	0.39
KIRP	chr2	55680869	Missense_Mutation	NA	L168P	0.26
KIRP	chr2	55636331	Missense_Mutation	novel	Q753R	0.4
KIRP	chr2	55672897	Missense_Mutation	novel	H288D	0.4
LIHC	chr2	55683809	Silent	NA	P143P	0.45
LIHC	chr2	55644706	In_Frame_Del	novel	Q611_V612del	0.2
LUAD	chr2	55667050	Nonsense_Mutation	NA	E373*	0.17
LUAD	chr2	55680882	Nonsense_Mutation	novel	E164*	0.18
LUAD	chr2	55693877	5'Flank	NA		0.59
LUAD	chr2	55640652	Missense_Mutation	novel	H708R	0.31
LUAD	chr2	55646414	Splice_Site	NA	X558_splice	0.39
LUAD	chr2	55647391	Nonsense_Mutation	NA	E520*	0.21
LUAD	chr2	55666992	Missense_Mutation	NA	Q392L	0.12
LUAD	chr2	55693873	5'Flank	novel		0.26
LUAD	chr2	55684997	Missense_Mutation	NA	L117V	0.56
LUAD	chr2	55685024	Missense_Mutation	novel	A108S	0.14
LUAD	chr2	55647424	Missense_Mutation	NA	V509L	0.15
LUSC	chr2	55693753	Missense_Mutation	NA	P24Q	0.26
LUSC	chr2	55680733	Missense_Mutation	novel	I182V	0.27
LUSC	chr2	55643215	Splice_Site	NA	X672_splice	0.52
LUSC	chr2	55672007	Silent	rs149239772	Y302Y	0.2
LUSC	chr2	55693679	Missense_Mutation	novel	V49L	0.2
LUSC	chr2	55672000	Missense_Mutation	novel	D305Y	0.32
LUSC	chr2	55683804	Missense_Mutation	novel	G145V	0.36
OV	chr2	55667018	Silent	novel	S383S	0.04
OV	chr2	55671340	Missense_Mutation	novel	D319H	0.41
PAAD	chr2	55640635	Missense_Mutation	novel	Q714K	0.04
PAAD	chr2	55644683	Missense_Mutation	novel	F620L	0.13
PAAD	chr2	55647367	Missense_Mutation	rs766817661	R528C	0.14
PCPG	chr2	55673000	Silent	novel	Q253Q	0.3
READ	chr2	55667067	Missense_Mutation	NA	L367H	0.43
READ	chr2	55656186	Missense_Mutation	NA	I462M	0.31
READ	chr2	55645364	Missense_Mutation	novel	N603H	0.33
READ	chr2	55679732	Missense_Mutation	novel	S210Y	0.41	KH_1
SARC	chr2	55654929	Frame_Shift_Del	novel	*C489Lfs5**	0.22
SARC	chr2	55660176	Missense_Mutation	novel	N422S	0.27
SKCM	chr2	55680730	Missense_Mutation	rs745631221	P183S	0.4
SKCM	chr2	55667055	Missense_Mutation	rs538251642	S371N	0.49
SKCM	chr2	55686389	Missense_Mutation	NA	S93F	0.2
SKCM	chr2	55667029	Missense_Mutation	NA	L380V	0.28
SKCM	chr2	55686416	Missense_Mutation	rs145552327	A84V	0.24
SKCM	chr2	55693757	Silent	NA	L23L	0.36
SKCM	chr2	55693876	5'Flank	NA		0.33
SKCM	chr2	55685009	Missense_Mutation	NA	P113S	0.51
SKCM	chr2	55693876	5'Flank	NA		0.29
SKCM	chr2	55660172	Silent	NA	F423F	0.54
SKCM	chr2	55685009	Missense_Mutation	NA	P113S	0.49
STAD	chr2	55645415	Silent	rs750328203	L586L	0.4
STAD	chr2	55693677	Silent	NA	V49V	0.08
STAD	chr2	55680719	Silent	NA	G186G	0.34
STAD	chr2	55643409	Silent	rs779794474	Q641Q	0.1
STAD	chr2	55672920	Missense_Mutation	rs143022417	S280L	0.27
STAD	chr2	55643395	Missense_Mutation	rs758915545	T646M	0.23
THYM	chr2	55693876	5'Flank	novel		0.41
UCEC	chr2	55645382	Nonsense_Mutation	NA	R597*	0.2
UCEC	chr2	55660160	Silent	rs779101982	Y427Y	0.11
UCEC	chr2	55656317	Nonsense_Mutation	novel	E447*	0.28
UCEC	chr2	55647394	Missense_Mutation	NA	P519T	0.43
UCEC	chr2	55640700	Missense_Mutation	novel	T692I	0.39
UCEC	chr2	55686377	Missense_Mutation	novel	P97L	0.32
UCEC	chr2	55636190	3'UTR	novel		0.39
UCEC	chr2	55656313	Missense_Mutation	NA	L448R	0.45
UCEC	chr2	55656176	Missense_Mutation	NA	F466V	0.23
UCEC	chr2	55693808	Missense_Mutation	novel	Y6N	0.38
UCEC	chr2	55679732	Missense_Mutation	novel	S210Y	0.21	KH_1
UCEC	chr2	55660175	Frame_Shift_Ins	novel	*N422Kfs14**	0.32
UCEC	chr2	55683818	Silent	novel	P140P	0.23
UCEC	chr2	55644684	Missense_Mutation	NA	F620C	0.32
UCEC	chr2	55636259	Missense_Mutation	novel	Q777R	0.28
UCEC	chr2	55647375	Missense_Mutation	NA	E525A	0.52
UCEC	chr2	55679764	Silent	novel	E199E	0.48
UCEC	chr2	55679739	Nonsense_Mutation	NA	E208*	0.56	KH_1
UCEC	chr2	55636161	3'UTR	novel		0.28
UCEC	chr2	55636343	Missense_Mutation	NA	R749Q	0.11
UCEC	chr2	55644684	Missense_Mutation	NA	F620C	0.2
UCEC	chr2	55643329	Missense_Mutation	novel	C668Y	0.22
UCEC	chr2	55667094	Splice_Site	novel	X358_splice	0.29
UCEC	chr2	55637564	Silent	rs777128850	G728G	0.33
UCEC	chr2	55645361	Missense_Mutation	novel	G604R	0.43
UCEC	chr2	55671325	Missense_Mutation	novel	L324I	0.38
UCEC	chr2	55680852	Splice_Region	novel		0.47
UCEC	chr2	55671365	Silent	novel	D310D	0.33
UCEC	chr2	55645417	Missense_Mutation	rs766238633	I585T	0.35
UCEC	chr2	55656317	Nonsense_Mutation	novel	E447*	0.19
UCEC	chr2	55673004	Missense_Mutation	novel	T252N	0.16
UCEC	chr2	55660165	Missense_Mutation	novel	H426Y	0.3
UCEC	chr2	55656151	Missense_Mutation	novel	S474F	0.38
UCS	chr2	55645429	Missense_Mutation	novel	A581V	0.29

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	DEL	0.0243	0.08832
PAAD	DEL	0.0598	0.2014

Survival Analysis

Cancer	P-value	Q-value
SARC	0.024	Kaplan-Meier Survival Analysis
ACC	0.00099	Kaplan-Meier Survival Analysis
HNSC	0.029	Kaplan-Meier Survival Analysis
LUSC	0.014	Kaplan-Meier Survival Analysis
PAAD	0.00011	Kaplan-Meier Survival Analysis
CESC	0.028	Kaplan-Meier Survival Analysis
KICH	0.0034	Kaplan-Meier Survival Analysis
UCEC	0.00045	Kaplan-Meier Survival Analysis
GBM	0.004	Kaplan-Meier Survival Analysis
LIHC	0.00011	Kaplan-Meier Survival Analysis
LGG	0.00034	Kaplan-Meier Survival Analysis

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000138035 (Gene tree)
Gene ID: 87178
Gene Symbol: PNPT1
Alias: PNPase|OLD35|old-35|DFNB70
Full Name: polyribonucleotide nucleotidyltransferase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 59,848 bases
Position: chr2:55,634,063-55,693,910
Accession: 23166
RBP type: canonical RBP
Summary: The protein encoded by this gene belongs to the evolutionary conserved polynucleotide phosphorylase family comprised of phosphate dependent 3'-to-5' exoribonucleases implicated in RNA processing and degradation. This enzyme is predominantly localized in the mitochondrial intermembrane space and is involved in import of RNA to mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency-13 and autosomal recessive nonsyndromic deafness-70. Related pseudogenes are found on chromosomes 3 and 7. [provided by RefSeq, Dec 2012]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000400646	KH_1	PF00013.29	1.7e-07	1	1
ENSP00000400646	RNase_PH	PF01138.21	7.8e-40	1	2
ENSP00000400646	RNase_PH	PF01138.21	7.8e-40	2	2
ENSP00000400646	PNPase	PF03726.14	1.6e-07	1	1
ENSP00000400646	S1	PF00575.23	0.00016	1	1
ENSP00000400646	RNase_PH_C	PF03725.15	2.1e-16	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
14963263	A mutation in polynucleotide phosphorylase from Escherichia coli impairing RNA binding and degradosome stability.	Nucleic Acids Res	2004 Feb 12	Regonesi ME	-
9211914	The mechanism of preferential degradation of polyadenylated RNA in the chloroplast. The exoribonuclease 100RNP/polynucleotide phosphorylase displays high binding affinity for poly(A) sequence.	J Biol Chem	1997 Jul 11	Lisitsky I	-
22210891	Crystal structure of human polynucleotide phosphorylase: insights into its domain function in RNA binding and degradation.	Nucleic Acids Res	2012 May	Lin CL	doi: 10.1093/nar/gkr1281
26438818	CsrA Participates in a PNPase Autoregulatory Mechanism by Selectively Repressing Translation of pnp Transcripts That Have Been Previously Processed by RNase III and PNPase.	J Bacteriol	2015 Dec	Park H	doi: 10.1128/JB.00721-15
9106202	RNase E: still a wonderfully mysterious enzyme.	Mol Microbiol	1997 Mar	Cohen SN	-
16237005	Function of the conserved S1 and KH domains in polynucleotide phosphorylase.	J Bacteriol	2005 Nov	Stickney LM	-
20090900	Crystal structure of the S. solfataricus archaeal exosome reveals conformational flexibility in the RNA-binding ring.	PLoS One	2010 Jan 15	Lu C	doi: 10.1371/journal.pone.0008739.
20114069	Nucleic acid and protein factors involved in Escherichia coli polynucleotide phosphorylase function on RNA.	Biochimie	2010 May	Fernandez-Ramirez F	doi: 10.1016/j.biochi.2010.01.004
17514363	The PNPase, exosome and RNA helicases as the building components of evolutionarily-conserved RNA degradation machines.	J Biomed Sci	2007 Jul	Lin-Chao S	-
17337072	The KH and S1 domains of Escherichia coli polynucleotide phosphorylase are necessary for autoregulation and growth at low temperature.	Biochim Biophys Acta	2007 Mar	Matus-Ortega ME	-
26973625	Polynucleotide Phosphorylase Regulates Multiple Virulence Factors and the Stabilities of Small RNAs RsmY/Z in Pseudomonas aeruginosa.	Front Microbiol	2016 Mar 2	Chen R	doi: 10.3389/fmicb.2016.00247
26598710	Direct observation of processive exoribonuclease motion using optical tweezers.	Proc Natl Acad Sci U S A	2015 Dec 8	Fazal FM	doi: 10.1073/pnas.1514028112
28376742	Polynucleotide phosphorylase is implicated in homologous recombination and DNA repair in Escherichia coli.	BMC Microbiol	2017 Apr 4	Carzaniga T	doi: 10.1186/s12866-017-0980-z.
30020492	Crystal structure of dimeric human PNPase reveals why disease-linked mutants suffer from low RNA import and degradation activities.	Nucleic Acids Res	2018 Sep 19	Golzarroshan B	doi: 10.1093/nar/gky642.
2432069	Nucleotide sequence of the pnp gene of Escherichia coli encoding polynucleotide phosphorylase. Homology of the primary structure of the protein with the RNA-binding domain of ribosomal protein S1.	J Biol Chem	1987 Jan 5	Regnier P	-
1383091	Translational initiation factors IF-1 and eIF-2 alpha share an RNA-binding motif with prokaryotic ribosomal protein S1 and polynucleotide phosphorylase.	Gene	1992 Sep 21	Gribskov M	-
9651346	Polynucleotide phosphorylase is a component of a novel plant poly(A) polymerase.	J Biol Chem	1998 Jul 10	Li QS	-
9179491	Comparison between the Escherichia coli and Bacillus subtilis genomes suggests that a major function of polynucleotide phosphorylase is to synthesize CDP.	DNA Res	1997 Feb 28	Danchin A	-
8113187	Characterization of a cell division gene from Bacillus subtilis that is required for vegetative and sporulation septum formation.	J Bacteriol	1994 Mar	Levin PA	-
12162954	Mutational analysis of polynucleotide phosphorylase from Escherichia coli.	J Mol Biol	2002 Aug 16	Jarrige A	-
12101094	A complex prediction: three-dimensional model of the yeast exosome.	EMBO Rep	2002 Jul	Aloy P	-
12035760	The Escherichia coli RNA degradosome: structure, function and relationship in other ribonucleolytic multienzyme complexes.	Biochem Soc Trans	2002 Apr	Carpousis AJ	-
11080643	A duplicated fold is the structural basis for polynucleotide phosphorylase catalytic activity, processivity, and regulation.	Structure	2000 Nov 15	Symmons MF	-
16055741	Defining the domains of human polynucleotide phosphorylase (hPNPaseOLD-35) mediating cellular senescence.	Mol Cell Biol	2005 Aug	Sarkar D	-
15509583	Modulation of yersinia type three secretion system by the S1 domain of polynucleotide phosphorylase.	J Biol Chem	2005 Jan 7	Rosenzweig JA	-
19509288	Human mitochondrial SUV3 and polynucleotide phosphorylase form a 330-kDa heteropentamer to cooperatively degrade double-stranded RNA with a 3'-to-5' directionality.	J Biol Chem	2009 Jul 31	Wang DD	doi: 10.1074/jbc.M109.009605
18083836	Analysis of the human polynucleotide phosphorylase (PNPase) reveals differences in RNA binding and response to phosphate compared to its bacterial and chloroplast counterparts.	RNA	2008 Feb	Portnoy V	-
17966418	Polynucleotide phosphorylase and the T3SS.	Adv Exp Med Biol	2007	Rosenzweig JA	-
17391372	Polynucleotide phosphorylase independently controls virulence factor expression levels and export in Yersinia spp.	FEMS Microbiol Lett	2007 May	Rosenzweig JA	-
17242308	The role of the S1 domain in exoribonucleolytic activity: substrate specificity and multimerization.	RNA	2007 Mar	Amblar M	-
17084501	Genetic analysis of polynucleotide phosphorylase structure and functions.	Biochimie	2007 Jan	Briani F	-
23457244	S1 and KH domains of polynucleotide phosphorylase determine the efficiency of RNA binding and autoregulation.	J Bacteriol	2013 May	Wong AG	doi: 10.1128/JB.00062-13
25825432	RNase III-Independent Autogenous Regulation of Escherichia coli Polynucleotide Phosphorylase via Translational Repression.	J Bacteriol	2015 Jun	Carzaniga T	doi: 10.1128/JB.00105-15
28835257	Long noncoding RNAs coordinate functions between mitochondria and the nucleus.	Epigenetics Chromatin	2017 Aug 23	Dong Y	doi: 10.1186/s13072-017-0149-x.
21126315	Analysis of the RNA degradosome complex in Vibrio angustum S14.	FEBS J	2010 Dec	Erce MA	doi: 10.1111/j.1742-4658.2010.07934.x.
23560592	Distinctive effects of domain deletions on the manganese-dependent DNA polymerase and DNA phosphorylase activities of Mycobacterium smegmatis polynucleotide phosphorylase.	Biochemistry	2013 Apr 30	Unciuleac MC	doi: 10.1021/bi400281w
9732274	Ribonuclease E organizes the protein interactions in the Escherichia coli RNA degradosome.	Genes Dev	1998 Sep 1	Vanzo NF	-
17507374	Initiation of decay of Bacillus subtilis trp leader RNA.	J Biol Chem	2007 Jul 13	Deikus G	-
21063756	The crystal structure of hexamer RraA from Pseudomonas aeruginosa reveals six conserved protein-protein interaction sites.	Protein J	2010 Nov	Tang J	doi: 10.1007/s10930-010-9293-x.
2459106	Stabilization of discrete mRNA breakdown products in ams pnp rnb multiple mutants of Escherichia coli K-12.	J Bacteriol	1988 Oct	Arraiano CM	-
14945	Effects of polyamines on the degradation of ribonucleic acids by polynucleotide phosphorylase of Micrococcus luteus.	J Biochem	1977 Feb	Igarashi K	-
11502194	Specific binding of 8-oxoguanine-containing RNA to polynucleotide phosphorylase protein.	Biochemistry	2001 Aug 21	Hayakawa H	-
11390393	Escherichia coli poly(A)-binding proteins that interact with components of degradosomes or impede RNA decay mediated by polynucleotide phosphorylase and RNase E.	J Biol Chem	2001 Aug 24	Feng Y	-
11134527	RNA degradosomes exist in vivo in Escherichia coli as multicomponent complexes associated with the cytoplasmic membrane via the N-terminal region of ribonuclease E.	Proc Natl Acad Sci U S A	2001 Jan 2	Liou GG	-
18306177	SsrA genes of streptomycetes and association of proteins to the tmRNA during development and cellular differentiation.	Proteomics	2008 Apr	Mikulik K	doi: 10.1002/pmic.200700560.
24075876	A conserved loop in polynucleotide phosphorylase (PNPase) essential for both RNA and ADP/phosphate binding.	Biochimie	2014 Feb	Carzaniga T	doi: 10.1016/j.biochi.2013.09.018

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000415374	PNPT1-202	3308	-	ENSP00000393953	783 (aa)	-	Q8TCS8
ENST00000415489	PNPT1-203	555	-	ENSP00000411057	139 (aa)	-	H7C3C5
ENST00000481066	PNPT1-206	1281	-	-	- (aa)	-	-
ENST00000447944	PNPT1-205	4411	XM_005264629	ENSP00000400646	783 (aa)	XP_005264686	Q8TCS8
ENST00000429805	PNPT1-204	583	-	ENSP00000411994	71 (aa)	-	F8WBI3
ENST00000260604	PNPT1-201	3596	-	ENSP00000260604	179 (aa)	-	H7BXF6
ENST00000625249	PNPT1-207	216	-	ENSP00000486227	71 (aa)	-	F8WBI3

Gene Model

Click here to download ENSG00000138035's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03018	RNA degradation	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000138035	Heart Failure	2.9347593E-004	-
ENSG00000138035	Blood Pressure	5.821e-006	19060910
ENSG00000138035	Blood Pressure	2.677e-005	19060910
ENSG00000138035	Blood Pressure	9.378e-006	19060910
ENSG00000138035	Blood Pressure	1.4e-005	19060910
ENSG00000138035	Body Weight	2.6980000E-005	-
ENSG00000138035	Body Weight	2.1730000E-005	-
ENSG00000138035	Body Weight	7.5780000E-005	-
ENSG00000138035	Body Weight	5.4190000E-005	-
ENSG00000138035	Nutritional and Metabolic Diseases	2.6640000E-005	-
ENSG00000138035	Cholesterol, LDL	4.9860000E-005	-
ENSG00000138035	Platelet Function Tests	5.8360505E-006	-
ENSG00000138035	Platelet Function Tests	7.2638000E-006	-
ENSG00000138035	Child Development Disorders, Pervasive	4.7078500E-005	-
ENSG00000138035	Respiratory Function Tests	2.1665000E-008	21946350
ENSG00000138035	Respiratory Function Tests	2.2117000E-008	21946350
ENSG00000138035	Respiratory Function Tests	1.7882000E-008	21946350
ENSG00000138035	Respiratory Function Tests	2.1456000E-008	21946350
ENSG00000138035	Respiratory Function Tests	2.0981000E-008	21946350
ENSG00000138035	Body Height	4E-8	20881960
ENSG00000138035	Amyotrophic Lateral Sclerosis	1E-6	19451621
ENSG00000138035	Immunoglobulins	5E-6	23382691
ENSG00000138035	Body Height	1E-25	25429064
ENSG00000138035	3-hydroxy-1-methylpropylmercapturic acid	4E-7	26053186
ENSG00000138035	Smoking	4E-7	26053186
ENSG00000138035	Hernia, Inguinal	1E-17	26686553

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000138035	rs6739788	2	55635220	?	Hypothyroidism	30595370			EFO_0004705

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000138035's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000138035	PNPT1	95	78.457	ENSAPOG00000005581	PNPT1	99	77.880	Acanthochromis_polyacanthus
ENSG00000138035	PNPT1	99	94.057	ENSAMEG00000003772	PNPT1	99	93.997	Ailuropoda_melanoleuca
ENSG00000138035	PNPT1	92	79.224	ENSACIG00000010140	PNPT1	99	79.224	Amphilophus_citrinellus
ENSG00000138035	PNPT1	97	78.068	ENSAOCG00000020109	PNPT1	99	78.068	Amphiprion_ocellaris
ENSG00000138035	PNPT1	94	77.642	ENSAPEG00000002299	PNPT1	99	77.642	Amphiprion_percula
ENSG00000138035	PNPT1	96	78.515	ENSATEG00000011164	PNPT1	98	78.515	Anabas_testudineus
ENSG00000138035	PNPT1	94	81.929	ENSAPLG00000002885	PNPT1	100	81.929	Anas_platyrhynchos
ENSG00000138035	PNPT1	99	79.040	ENSACAG00000003692	PNPT1	99	79.040	Anolis_carolinensis
ENSG00000138035	PNPT1	99	95.613	ENSANAG00000023709	PNPT1	99	95.652	Aotus_nancymaae
ENSG00000138035	PNPT1	97	77.749	ENSACLG00000024267	PNPT1	99	77.749	Astatotilapia_calliptera
ENSG00000138035	PNPT1	91	78.947	ENSAMXG00000042321	PNPT1	99	78.947	Astyanax_mexicanus
ENSG00000138035	PNPT1	99	91.979	ENSBTAG00000008909	PNPT1	99	91.816	Bos_taurus
ENSG00000138035	PNPT1	91	42.244	WBGene00015266	BE0003N10.1	96	42.244	Caenorhabditis_elegans
ENSG00000138035	PNPT1	99	96.164	ENSCJAG00000009740	PNPT1	99	96.164	Callithrix_jacchus
ENSG00000138035	PNPT1	99	88.205	ENSCAFG00000002891	PNPT1	99	88.213	Canis_familiaris
ENSG00000138035	PNPT1	99	93.920	ENSCAFG00020026841	PNPT1	99	93.862	Canis_lupus_dingo
ENSG00000138035	PNPT1	99	88.486	ENSCHIG00000025034	PNPT1	99	88.363	Capra_hircus
ENSG00000138035	PNPT1	99	93.806	ENSTSYG00000006536	PNPT1	99	93.862	Carlito_syrichta
ENSG00000138035	PNPT1	91	72.992	ENSCAPG00000013300	PNPT1	99	73.114	Cavia_aperea
ENSG00000138035	PNPT1	99	92.000	ENSCPOG00000011008	PNPT1	99	91.944	Cavia_porcellus
ENSG00000138035	PNPT1	99	95.484	ENSCCAG00000037909	PNPT1	99	95.524	Cebus_capucinus
ENSG00000138035	PNPT1	100	96.296	ENSCATG00000031551	PNPT1	100	96.296	Cercocebus_atys
ENSG00000138035	PNPT1	99	72.129	ENSCATG00000036442	-	99	71.923	Cercocebus_atys
ENSG00000138035	PNPT1	99	92.516	ENSCLAG00000006240	PNPT1	99	92.583	Chinchilla_lanigera
ENSG00000138035	PNPT1	100	97.449	ENSCSAG00000014324	PNPT1	100	97.449	Chlorocebus_sabaeus
ENSG00000138035	PNPT1	86	93.277	ENSCHOG00000007360	PNPT1	99	82.418	Choloepus_hoffmanni
ENSG00000138035	PNPT1	99	80.779	ENSCPBG00000020856	PNPT1	99	80.779	Chrysemys_picta_bellii
ENSG00000138035	PNPT1	100	97.318	ENSCANG00000034019	PNPT1	100	97.318	Colobus_angolensis_palliatus
ENSG00000138035	PNPT1	99	74.264	ENSCANG00000028159	-	99	74.838	Colobus_angolensis_palliatus
ENSG00000138035	PNPT1	99	90.781	ENSCGRG00001012245	Pnpt1	99	90.863	Cricetulus_griseus_chok1gshd
ENSG00000138035	PNPT1	99	91.355	ENSCGRG00000007624	Pnpt1	99	91.432	Cricetulus_griseus_crigri
ENSG00000138035	PNPT1	91	76.371	ENSCSEG00000000809	PNPT1	99	76.371	Cynoglossus_semilaevis
ENSG00000138035	PNPT1	77	81.884	ENSCVAG00000010037	PNPT1	96	81.884	Cyprinodon_variegatus
ENSG00000138035	PNPT1	99	92.129	ENSDNOG00000046753	PNPT1	99	92.199	Dasypus_novemcinctus
ENSG00000138035	PNPT1	99	91.979	ENSDORG00000011409	Pnpt1	99	91.816	Dipodomys_ordii
ENSG00000138035	PNPT1	93	57.337	FBgn0039846	PNPase	95	57.337	Drosophila_melanogaster
ENSG00000138035	PNPT1	86	87.395	ENSETEG00000001582	-	99	68.327	Echinops_telfairi
ENSG00000138035	PNPT1	92	55.201	ENSEBUG00000010305	PNPT1	94	55.201	Eptatretus_burgeri
ENSG00000138035	PNPT1	99	94.567	ENSEASG00005001974	PNPT1	99	94.501	Equus_asinus_asinus
ENSG00000138035	PNPT1	99	94.567	ENSECAG00000020058	PNPT1	98	95.205	Equus_caballus
ENSG00000138035	PNPT1	96	86.628	ENSEEUG00000015610	PNPT1	99	82.293	Erinaceus_europaeus
ENSG00000138035	PNPT1	97	77.023	ENSELUG00000004795	PNPT1	99	77.023	Esox_lucius
ENSG00000138035	PNPT1	99	94.696	ENSFCAG00000013236	PNPT1	99	94.501	Felis_catus
ENSG00000138035	PNPT1	93	81.731	ENSFALG00000011214	PNPT1	100	81.731	Ficedula_albicollis
ENSG00000138035	PNPT1	99	90.921	ENSFDAG00000017446	PNPT1	100	90.921	Fukomys_damarensis
ENSG00000138035	PNPT1	96	77.428	ENSFHEG00000006495	PNPT1	99	79.070	Fundulus_heteroclitus
ENSG00000138035	PNPT1	96	75.265	ENSGMOG00000006805	PNPT1	98	75.265	Gadus_morhua
ENSG00000138035	PNPT1	97	79.974	ENSGALG00000043545	PNPT1	95	79.974	Gallus_gallus
ENSG00000138035	PNPT1	95	78.162	ENSGAFG00000019681	PNPT1	98	78.532	Gambusia_affinis
ENSG00000138035	PNPT1	96	75.989	ENSGACG00000010840	PNPT1	98	75.989	Gasterosteus_aculeatus
ENSG00000138035	PNPT1	100	99.617	ENSGGOG00000006867	PNPT1	100	99.617	Gorilla_gorilla
ENSG00000138035	PNPT1	99	80.258	ENSGGOG00000041496	-	99	80.645	Gorilla_gorilla
ENSG00000138035	PNPT1	97	77.487	ENSHBUG00000013041	PNPT1	99	77.487	Haplochromis_burtoni
ENSG00000138035	PNPT1	89	82.808	ENSHGLG00000010054	-	95	82.808	Heterocephalus_glaber_female
ENSG00000138035	PNPT1	99	91.721	ENSHGLG00000007480	PNPT1	99	91.688	Heterocephalus_glaber_female
ENSG00000138035	PNPT1	99	77.620	ENSHGLG00100007397	-	99	77.749	Heterocephalus_glaber_male
ENSG00000138035	PNPT1	99	91.721	ENSHGLG00100010920	PNPT1	99	91.688	Heterocephalus_glaber_male
ENSG00000138035	PNPT1	92	65.103	ENSHCOG00000002817	PNPT1	98	65.103	Hippocampus_comes
ENSG00000138035	PNPT1	93	78.796	ENSIPUG00000014624	PNPT1	100	78.796	Ictalurus_punctatus
ENSG00000138035	PNPT1	99	92.967	ENSSTOG00000006304	PNPT1	99	92.967	Ictidomys_tridecemlineatus
ENSG00000138035	PNPT1	99	91.613	ENSJJAG00000019227	Pnpt1	99	91.688	Jaculus_jaculus
ENSG00000138035	PNPT1	96	77.249	ENSKMAG00000017389	PNPT1	98	77.249	Kryptolebias_marmoratus
ENSG00000138035	PNPT1	97	76.147	ENSLBEG00000027692	PNPT1	99	76.147	Labrus_bergylta
ENSG00000138035	PNPT1	90	80.309	ENSLACG00000011059	PNPT1	99	81.792	Latimeria_chalumnae
ENSG00000138035	PNPT1	95	78.104	ENSLOCG00000015375	PNPT1	94	78.104	Lepisosteus_oculatus
ENSG00000138035	PNPT1	96	89.535	ENSLAFG00000021462	PNPT1	99	85.350	Loxodonta_africana
ENSG00000138035	PNPT1	100	97.573	ENSMFAG00000001927	PNPT1	100	97.573	Macaca_fascicularis
ENSG00000138035	PNPT1	87	97.129	ENSMMUG00000007003	PNPT1	100	97.129	Macaca_mulatta
ENSG00000138035	PNPT1	95	97.297	ENSMNEG00000038589	PNPT1	100	98.217	Macaca_nemestrina
ENSG00000138035	PNPT1	99	70.294	ENSMLEG00000028524	-	100	70.115	Mandrillus_leucophaeus
ENSG00000138035	PNPT1	100	94.253	ENSMLEG00000038706	PNPT1	100	94.253	Mandrillus_leucophaeus
ENSG00000138035	PNPT1	93	75.034	ENSMAMG00000021954	PNPT1	95	75.034	Mastacembelus_armatus
ENSG00000138035	PNPT1	97	77.749	ENSMZEG00005027363	PNPT1	99	77.749	Maylandia_zebra
ENSG00000138035	PNPT1	94	81.992	ENSMGAG00000001952	PNPT1	100	81.992	Meleagris_gallopavo
ENSG00000138035	PNPT1	99	90.863	ENSMAUG00000013652	Pnpt1	99	90.863	Mesocricetus_auratus
ENSG00000138035	PNPT1	99	94.757	ENSMICG00000009369	PNPT1	99	94.757	Microcebus_murinus
ENSG00000138035	PNPT1	99	91.753	ENSMOCG00000002820	Pnpt1	99	91.592	Microtus_ochrogaster
ENSG00000138035	PNPT1	91	75.657	ENSMMOG00000007480	PNPT1	99	75.657	Mola_mola
ENSG00000138035	PNPT1	99	84.852	ENSMODG00000001984	PNPT1	99	84.860	Monodelphis_domestica
ENSG00000138035	PNPT1	96	77.807	ENSMALG00000018484	PNPT1	98	77.807	Monopterus_albus
ENSG00000138035	PNPT1	98	92.288	MGP_CAROLIEiJ_G0016153	Pnpt1	99	91.944	Mus_caroli
ENSG00000138035	PNPT1	98	91.623	ENSMUSG00000020464	Pnpt1	99	91.049	Mus_musculus
ENSG00000138035	PNPT1	99	91.742	MGP_PahariEiJ_G0016737	Pnpt1	99	91.816	Mus_pahari
ENSG00000138035	PNPT1	100	91.443	MGP_SPRETEiJ_G0016996	Pnpt1	99	93.048	Mus_spretus
ENSG00000138035	PNPT1	99	93.806	ENSMPUG00000002353	PNPT1	99	93.750	Mustela_putorius_furo
ENSG00000138035	PNPT1	99	92.010	ENSMLUG00000003886	PNPT1	99	91.847	Myotis_lucifugus
ENSG00000138035	PNPT1	92	70.303	ENSNGAG00000015678	-	96	73.370	Nannospalax_galili
ENSG00000138035	PNPT1	99	93.661	ENSNGAG00000020856	-	99	93.223	Nannospalax_galili
ENSG00000138035	PNPT1	86	75.630	ENSNBRG00000012517	PNPT1	87	76.980	Neolamprologus_brichardi
ENSG00000138035	PNPT1	100	95.658	ENSNLEG00000009354	PNPT1	100	95.658	Nomascus_leucogenys
ENSG00000138035	PNPT1	92	84.157	ENSNLEG00000003327	-	99	84.157	Nomascus_leucogenys
ENSG00000138035	PNPT1	100	89.400	ENSOPRG00000010232	-	100	89.400	Ochotona_princeps
ENSG00000138035	PNPT1	99	92.258	ENSODEG00000012137	PNPT1	99	92.327	Octodon_degus
ENSG00000138035	PNPT1	99	76.282	ENSONIG00000000983	PNPT1	99	76.282	Oreochromis_niloticus
ENSG00000138035	PNPT1	90	86.752	ENSOANG00000011178	PNPT1	99	86.752	Ornithorhynchus_anatinus
ENSG00000138035	PNPT1	99	93.943	ENSOCUG00000006889	PNPT1	99	93.870	Oryctolagus_cuniculus
ENSG00000138035	PNPT1	94	79.212	ENSORLG00000004335	PNPT1	92	79.212	Oryzias_latipes
ENSG00000138035	PNPT1	87	72.903	ENSORLG00020012923	-	74	72.903	Oryzias_latipes_hni
ENSG00000138035	PNPT1	94	78.940	ENSORLG00015018951	PNPT1	99	79.172	Oryzias_latipes_hsok
ENSG00000138035	PNPT1	66	87.288	ENSOMEG00000012385	-	100	87.288	Oryzias_melastigma
ENSG00000138035	PNPT1	100	91.635	ENSOGAG00000009840	PNPT1	100	91.635	Otolemur_garnettii
ENSG00000138035	PNPT1	99	92.119	ENSOARG00000002164	PNPT1	99	91.954	Ovis_aries
ENSG00000138035	PNPT1	90	99.684	ENSPPAG00000024705	PNPT1	100	99.684	Pan_paniscus
ENSG00000138035	PNPT1	99	77.041	ENSPPAG00000040514	-	99	76.982	Pan_paniscus
ENSG00000138035	PNPT1	99	94.955	ENSPPRG00000001366	PNPT1	99	94.757	Panthera_pardus
ENSG00000138035	PNPT1	99	94.825	ENSPTIG00000014915	PNPT1	99	94.629	Panthera_tigris_altaica
ENSG00000138035	PNPT1	99	77.390	ENSPTRG00000051411	-	99	77.332	Pan_troglodytes
ENSG00000138035	PNPT1	100	99.745	ENSPTRG00000011934	PNPT1	100	99.745	Pan_troglodytes
ENSG00000138035	PNPT1	100	97.701	ENSPANG00000022846	PNPT1	100	97.701	Papio_anubis
ENSG00000138035	PNPT1	99	75.189	ENSPKIG00000021612	PNPT1	99	75.895	Paramormyrops_kingsleyae
ENSG00000138035	PNPT1	96	82.157	ENSPSIG00000013120	PNPT1	98	82.157	Pelodiscus_sinensis
ENSG00000138035	PNPT1	94	60.000	ENSPMGG00000003699	-	97	60.000	Periophthalmus_magnuspinnatus
ENSG00000138035	PNPT1	99	90.955	ENSPEMG00000004284	Pnpt1	99	90.955	Peromyscus_maniculatus_bairdii
ENSG00000138035	PNPT1	92	74.242	ENSPMAG00000008932	PNPT1	98	74.242	Petromyzon_marinus
ENSG00000138035	PNPT1	99	85.476	ENSPCIG00000010236	PNPT1	99	85.441	Phascolarctos_cinereus
ENSG00000138035	PNPT1	95	78.562	ENSPFOG00000010229	PNPT1	98	78.562	Poecilia_formosa
ENSG00000138035	PNPT1	95	78.695	ENSPLAG00000009008	PNPT1	98	78.695	Poecilia_latipinna
ENSG00000138035	PNPT1	96	77.822	ENSPMEG00000004192	PNPT1	100	79.261	Poecilia_mexicana
ENSG00000138035	PNPT1	93	78.984	ENSPREG00000003072	PNPT1	100	78.984	Poecilia_reticulata
ENSG00000138035	PNPT1	100	98.340	ENSPPYG00000012399	PNPT1	100	98.340	Pongo_abelii
ENSG00000138035	PNPT1	92	83.773	ENSPCAG00000010806	PNPT1	99	83.906	Procavia_capensis
ENSG00000138035	PNPT1	92	82.711	ENSPCOG00000015664	PNPT1	99	82.711	Propithecus_coquereli
ENSG00000138035	PNPT1	96	93.023	ENSPVAG00000005379	PNPT1	89	79.116	Pteropus_vampyrus
ENSG00000138035	PNPT1	93	77.747	ENSPNYG00000000363	PNPT1	96	77.747	Pundamilia_nyererei
ENSG00000138035	PNPT1	95	81.041	ENSPNAG00000010891	PNPT1	97	81.041	Pygocentrus_nattereri
ENSG00000138035	PNPT1	97	91.963	ENSRNOG00000003600	Pnpt1	99	91.816	Rattus_norvegicus
ENSG00000138035	PNPT1	100	97.446	ENSRBIG00000043016	PNPT1	100	97.446	Rhinopithecus_bieti
ENSG00000138035	PNPT1	100	97.318	ENSRROG00000040537	PNPT1	100	97.318	Rhinopithecus_roxellana
ENSG00000138035	PNPT1	99	93.161	ENSSBOG00000032574	PNPT1	99	96.581	Saimiri_boliviensis_boliviensis
ENSG00000138035	PNPT1	86	85.714	ENSSHAG00000014040	PNPT1	99	87.805	Sarcophilus_harrisii
ENSG00000138035	PNPT1	93	72.452	ENSSFOG00015017596	PNPT1	95	72.452	Scleropages_formosus
ENSG00000138035	PNPT1	95	77.493	ENSSMAG00000018471	PNPT1	99	76.923	Scophthalmus_maximus
ENSG00000138035	PNPT1	95	78.869	ENSSDUG00000018584	PNPT1	96	79.060	Seriola_dumerili
ENSG00000138035	PNPT1	95	78.735	ENSSLDG00000023385	PNPT1	99	77.266	Seriola_lalandi_dorsalis
ENSG00000138035	PNPT1	86	84.694	ENSSARG00000012819	PNPT1	87	84.848	Sorex_araneus
ENSG00000138035	PNPT1	99	77.806	ENSSPUG00000011785	PNPT1	100	77.806	Sphenodon_punctatus
ENSG00000138035	PNPT1	95	76.565	ENSSPAG00000016880	PNPT1	98	76.565	Stegastes_partitus
ENSG00000138035	PNPT1	99	92.885	ENSSSCG00000031882	PNPT1	99	92.839	Sus_scrofa
ENSG00000138035	PNPT1	93	81.918	ENSTGUG00000006908	PNPT1	100	81.918	Taeniopygia_guttata
ENSG00000138035	PNPT1	95	76.070	ENSTRUG00000005495	PNPT1	99	75.393	Takifugu_rubripes
ENSG00000138035	PNPT1	93	77.534	ENSTNIG00000007460	PNPT1	99	76.882	Tetraodon_nigroviridis
ENSG00000138035	PNPT1	97	73.988	ENSTBEG00000010788	PNPT1	99	64.158	Tupaia_belangeri
ENSG00000138035	PNPT1	93	93.544	ENSTTRG00000000029	PNPT1	99	93.544	Tursiops_truncatus
ENSG00000138035	PNPT1	92	95.957	ENSUAMG00000017133	PNPT1	99	95.789	Ursus_americanus
ENSG00000138035	PNPT1	99	94.567	ENSUMAG00000018844	PNPT1	99	94.501	Ursus_maritimus
ENSG00000138035	PNPT1	96	89.595	ENSVPAG00000007097	PNPT1	99	83.780	Vicugna_pacos
ENSG00000138035	PNPT1	99	93.661	ENSVVUG00000010034	PNPT1	99	93.606	Vulpes_vulpes
ENSG00000138035	PNPT1	95	79.892	ENSXETG00000006075	pnpt1	94	79.892	Xenopus_tropicalis
ENSG00000138035	PNPT1	92	80.417	ENSXCOG00000013381	PNPT1	97	80.417	Xiphophorus_couchianus
ENSG00000138035	PNPT1	95	78.429	ENSXMAG00000016907	PNPT1	98	80.278	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000175	3'-5'-exoribonuclease activity	21873635.	IBA	Function
GO:0000175	3'-5'-exoribonuclease activity	19509288.	IDA	Function
GO:0000957	mitochondrial RNA catabolic process	21873635.	IBA	Process
GO:0000957	mitochondrial RNA catabolic process	18501193.	IDA	Process
GO:0000958	mitochondrial mRNA catabolic process	21873635.	IBA	Process
GO:0000958	mitochondrial mRNA catabolic process	20691904.	IDA	Process
GO:0000962	positive regulation of mitochondrial RNA catabolic process	19509288.	IDA	Process
GO:0000963	mitochondrial RNA processing	21873635.	IBA	Process
GO:0000964	mitochondrial RNA 5'-end processing	18083837.	IMP	Process
GO:0000965	mitochondrial RNA 3'-end processing	21873635.	IBA	Process
GO:0000965	mitochondrial RNA 3'-end processing	18083837.	IMP	Process
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0004654	polyribonucleotide nucleotidyltransferase activity	21873635.	IBA	Function
GO:0004654	polyribonucleotide nucleotidyltransferase activity	18083836.	IDA	Function
GO:0005515	protein binding	16934922.	IPI	Function
GO:0005634	nucleus	-	IEA	Component
GO:0005737	cytoplasm	16055741.	IDA	Component
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005739	mitochondrion	16055741.19864255.20691904.	IDA	Component
GO:0005758	mitochondrial intermembrane space	16966381.	IDA	Component
GO:0005789	endoplasmic reticulum membrane	-	IEA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006401	RNA catabolic process	21873635.	IBA	Process
GO:0006401	RNA catabolic process	18083836.	IDA	Process
GO:0006402	mRNA catabolic process	12721301.16055741.	IDA	Process
GO:0008266	poly(U) RNA binding	18083836.	IDA	Function
GO:0034046	poly(G) binding	18083836.	IDA	Function
GO:0034599	cellular response to oxidative stress	18501193.	IDA	Process
GO:0035198	miRNA binding	20547861.	IDA	Function
GO:0035458	cellular response to interferon-beta	16410805.	IDA	Process
GO:0035927	RNA import into mitochondrion	20691904.	IDA	Process
GO:0035928	rRNA import into mitochondrion	20691904.	IDA	Process
GO:0042788	polysomal ribosome	-	IEA	Component
GO:0043457	regulation of cellular respiration	-	ISS	Process
GO:0043631	RNA polyadenylation	18083836.	IDA	Process
GO:0045025	mitochondrial degradosome	19509288.	IDA	Component
GO:0045926	negative regulation of growth	12721301.	IDA	Process
GO:0051260	protein homooligomerization	20691904.	IDA	Process
GO:0051591	response to cAMP	-	IEA	Process
GO:0060416	response to growth hormone	-	IEA	Process
GO:0061014	positive regulation of mRNA catabolic process	16410805.	IMP	Process
GO:0070207	protein homotrimerization	19509288.20691904.	IDA	Process
GO:0070584	mitochondrion morphogenesis	-	ISS	Process
GO:0071042	nuclear polyadenylation-dependent mRNA catabolic process	16934922.	IDA	Process
GO:0071850	mitotic cell cycle arrest	12721301.	IDA	Process
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	-	IEA	Process
GO:0097222	mitochondrial mRNA polyadenylation	18083837.	IMP	Process
GO:0097421	liver regeneration	-	IEA	Process
GO:2000627	positive regulation of miRNA catabolic process	20547861.	IDA	Process
GO:2000772	regulation of cellular senescence	16055741.	IDA	Process

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Note: to get the extension of tumor abbreviations.