EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26311411	Myoferlin plays a key role in VEGFA secretion and impacts tumor-associated angiogenesis in human pancreas cancer.	Int J Cancer	2016 Feb 1	Fahmy K	doi: 10.1002/ijc.29820
22761893	Myoferlin depletion in breast cancer cells promotes mesenchymal to epithelial shape change and stalls invasion.	PLoS One	2012	Li R	doi: 10.1371/journal.pone.0039766
27432471	Quantitative proteomics identifies myoferlin as a novel regulator of A Disintegrin and Metalloproteinase 12 in HeLa cells.	J Proteomics	2016 Oct 4	Zhou Y	doi: 10.1016/j.jprot.2016.07.015
27845903	Myoferlin is a novel exosomal protein and functional regulator of cancer-derived exosomes.	Oncotarget	2016 Dec 13	Blomme A	doi: 10.18632/oncotarget.13276.
23864327	Myoferlin is a key regulator of EGFR activity in breast cancer.	Cancer Res	2013 Sep 1	Turtoi A	doi: 10.1158/0008-5472.CAN-13-1142
22135466	Mechanistic modeling of the effects of myoferlin on tumor cell invasion.	Proc Natl Acad Sci U S A	2011 Dec 13	Eisenberg MC	doi: 10.1073/pnas.1116327108
25631868	Myoferlin depletion elevates focal adhesion kinase and paxillin phosphorylation and enhances cell-matrix adhesion in breast cancer cells.	Am J Physiol Cell Physiol	2015 Apr 15	Blackstone BN	doi: 10.1152/ajpcell.00276.2014

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr10	93431419	Missense_Mutation	novel	Q112K	0.04
ACC	chr10	93343905	Missense_Mutation	rs201449564	R1426Q	0.94
BLCA	chr10	93313135	Missense_Mutation	rs199884146	P1925L	0.54
BLCA	chr10	93323311	Frame_Shift_Del	novel	*L1771Sfs41**	0.37
BLCA	chr10	93349933	Frame_Shift_Del	novel	*Q1320Rfs23**	0.39
BLCA	chr10	93381330	Missense_Mutation	novel	V589I	0.3
BLCA	chr10	93387862	Missense_Mutation	NA	L545F	0.04
BLCA	chr10	93310113	Missense_Mutation	novel	F2018L	0.24
BLCA	chr10	93353813	Missense_Mutation	NA	S1160L	0.25
BLCA	chr10	93373068	In_Frame_Del	novel	P773del	0.12
BLCA	chr10	93351209	Silent	novel	L1303L	0.15
BLCA	chr10	93379868	Silent	novel	R666R	0.14
BLCA	chr10	93381251	Missense_Mutation	NA	S615L	0.5
BLCA	chr10	93399414	Missense_Mutation	novel	E400G	0.18
BLCA	chr10	93351539	Missense_Mutation	novel	F1232L	0.3
BLCA	chr10	93310573	Missense_Mutation	novel	R1987L	0.3
BLCA	chr10	93313185	Silent	NA	H1908H	0.36
BLCA	chr10	93353884	Silent	novel	V1136V	0.11
BLCA	chr10	93361515	Missense_Mutation	novel	P971T	0.05
BLCA	chr10	93351829	Frame_Shift_Del	novel	*I1166Mfs10**	0.69
BLCA	chr10	93306903	3'UTR	novel		0.34
BLCA	chr10	93363981	Missense_Mutation	rs188501773	E950K	0.53
BLCA	chr10	93404038	Silent	novel	L276L	0.28
BLCA	chr10	93482284	5'Flank	novel		0.58
BLCA	chr10	93397246	Splice_Site	NA	X445_splice	0.17
BLCA	chr10	93482236	5'Flank	novel		0.38
BRCA	chr10	93313089	Silent	NA	L1940L	0.14
BRCA	chr10	93426095	Missense_Mutation	rs557119618	G137R	0.17
BRCA	chr10	93319963	Missense_Mutation	NA	R1836T	0.55
BRCA	chr10	93313152	Missense_Mutation	NA	C1919W	0.15
BRCA	chr10	93313043	Nonsense_Mutation	novel	K1956*	0.5
BRCA	chr10	93328881	Silent	novel	L1671L	0.08
BRCA	chr10	93325841	Silent	rs772814311	Q1752Q	0.49
BRCA	chr10	93328909	Missense_Mutation	NA	S1662C	0.19
BRCA	chr10	93351752	Silent	rs769006926	F1192F	0.28
BRCA	chr10	93387813	Missense_Mutation	NA	D561G	0.27
BRCA	chr10	93351773	Silent	rs368030537	T1185T	0.47
BRCA	chr10	93353868	Missense_Mutation	rs543442746	R1142C	0.33
BRCA	chr10	93399445	Missense_Mutation	novel	D390H	0.29
BRCA	chr10	93333902	Silent	novel	R1525R	0.25
BRCA	chr10	93369670	Missense_Mutation	NA	G855A	0.26
BRCA	chr10	93310079	Missense_Mutation	rs369733924	G2030S	0.24
CESC	chr10	93328862	Nonsense_Mutation	NA	Q1678*	0.13
CESC	chr10	93335984	Silent	rs763946104	T1500T	0.4
CESC	chr10	93323163	Missense_Mutation	rs558864109	R1791C	0.36
CESC	chr10	93363997	Silent	rs757352331	G944G	0.22
CESC	chr10	93369768	Frame_Shift_Ins	novel	*E823Rfs15**	0.38
CESC	chr10	93369770	Nonsense_Mutation	novel	Q822*	0.38
CESC	chr10	93316811	Splice_Region	novel	E1867E	0.41
CESC	chr10	93355721	Missense_Mutation	rs777087223	E1104K	0.46
CESC	chr10	93369678	Silent	rs780131150	F852F	0.39
CESC	chr10	93404068	Silent	novel	Y266Y	0.38
CESC	chr10	93347632	Missense_Mutation	rs766655843	V1412I	0.32
CESC	chr10	93351821	Silent	novel	L1169L	0.27
CESC	chr10	93353859	Missense_Mutation	NA	V1145I	0.17
CESC	chr10	93361538	Missense_Mutation	NA	S963L	0.42
CESC	chr10	93478199	Intron	novel		0.27
CESC	chr10	93478213	Intron	NA		0.34
CESC	chr10	93351742	Missense_Mutation	novel	E1196Q	0.36
CESC	chr10	93431502	Missense_Mutation	rs200304153	A84V	0.21
COAD	chr10	93310063	Missense_Mutation	novel	L2035H	0.47
COAD	chr10	93363998	Frame_Shift_Del	NA	*G944Afs24**	0.38
COAD	chr10	93482117	Silent	NA	V26V	0.34
COAD	chr10	93329803	Nonsense_Mutation	NA	E1615*	0.33
COAD	chr10	93482187	Missense_Mutation	rs185721667	R3Q	0.48
COAD	chr10	93310043	Missense_Mutation	NA	A2042T	0.14
COAD	chr10	93310568	Missense_Mutation	rs756750552	E1989K	0.32
COAD	chr10	93347731	Missense_Mutation	novel	D1379N	0.25
COAD	chr10	93333762	Missense_Mutation	novel	G1572D	0.29
COAD	chr10	93381263	Missense_Mutation	novel	K611T	0.22
COAD	chr10	93325946	Missense_Mutation	novel	H1717Q	0.45
COAD	chr10	93392942	Silent	rs11187410	S477S	0.34
COAD	chr10	93353891	Splice_Region	rs749035035		0.46
COAD	chr10	93351550	Nonsense_Mutation	rs751178586	R1229*	0.52
COAD	chr10	93431502	Missense_Mutation	rs200304153	A84V	0.33
COAD	chr10	93374897	Nonsense_Mutation	rs780482700	R723*	0.31
COAD	chr10	93306783	3'UTR	novel		0.56
COAD	chr10	93409731	Frame_Shift_Del	NA	*E148Kfs38**	0.31
COAD	chr10	93329785	Frame_Shift_Del	NA	*S1621Lfs14**	0.18
COAD	chr10	93361544	Missense_Mutation	NA	A961V	0.47
COAD	chr10	93313163	Missense_Mutation	NA	P1916S	0.26
COAD	chr10	93323338	Silent	NA	V1764V	0.28
COAD	chr10	93397232	Intron	novel		0.14
COAD	chr10	93369732	Silent	NA	L834L	0.19
COAD	chr10	93399393	Frame_Shift_Del	rs752546951	*K407Rfs6**	0.08
COAD	chr10	93482234	5'Flank	novel		0.44
COAD	chr10	93374888	Silent	novel	R726R	0.17
COAD	chr10	93353890	Splice_Region	rs775303908		0.47
COAD	chr10	93482292	5'Flank	novel		0.4
COAD	chr10	93351566	Missense_Mutation	NA	K1223N	0.11
COAD	chr10	93325861	Missense_Mutation	novel	T1746A	0.08
COAD	chr10	93356778	Missense_Mutation	novel	K1064R	0.09
COAD	chr10	93359879	Missense_Mutation	rs370328569	R1025Q	0.22
COAD	chr10	93313190	Missense_Mutation	rs138208183	R1907C	0.41
COAD	chr10	93482282	5'Flank	novel		0.31
COAD	chr10	93319898	Missense_Mutation	rs771346954	E1858K	0.33
COAD	chr10	93343891	Missense_Mutation	rs775970286	E1431K	0.12
COAD	chr10	93456927	Missense_Mutation	NA	K33N	0.26
COAD	chr10	93366454	Missense_Mutation	novel	E897D	0.34
COAD	chr10	93323138	Missense_Mutation	NA	D1799G	0.21
COAD	chr10	93351751	Missense_Mutation	rs375965848	D1193N	0.13
COAD	chr10	93353890	Splice_Region	rs775303908		0.28
COAD	chr10	93310041	Silent	rs747850850	A2042A	0.48
COAD	chr10	93310618	Missense_Mutation	novel	I1972T	0.05
COAD	chr10	93381361	Silent	novel	A578A	0.26
COAD	chr10	93347687	Silent	rs199976582	T1393T	0.18
DLBC	chr10	93329730	Missense_Mutation	rs773089825	I1639T	0.44
ESCA	chr10	93310611	Missense_Mutation	novel	N1974K	0.46
ESCA	chr10	93325909	Missense_Mutation	rs777800718	H1730Y	0.13
GBM	chr10	93366502	Silent	novel	G881G	0.46
GBM	chr10	93374922	Silent	rs372347097	N714N	0.75
GBM	chr10	93389092	Missense_Mutation	NA	Y507H	0.64
GBM	chr10	93313108	Missense_Mutation	novel	K1934I	0.16
GBM	chr10	93359835	Missense_Mutation	novel	R1040G	0.06
GBM	chr10	93320003	Missense_Mutation	novel	G1823C	0.07
GBM	chr10	93310568	Missense_Mutation	rs756750552	E1989K	0.23
GBM	chr10	93313158	Silent	novel	E1917E	0.2
GBM	chr10	93319883	Missense_Mutation	rs780830520	V1863I	0.43
GBM	chr10	93328823	Missense_Mutation	novel	L1691I	0.2
GBM	chr10	93343891	Missense_Mutation	rs775970286	E1431K	0.48
GBM	chr10	93356739	Missense_Mutation	novel	R1077M	0.41
GBM	chr10	93363987	Missense_Mutation	novel	P948S	0.44
GBM	chr10	93409604	Missense_Mutation	rs374976050	R190Q	0.24
GBM	chr10	93482248	5'Flank	novel		0.35
GBM	chr10	93351456	Frame_Shift_Del	novel	*C1260Sfs6**	0.51
GBM	chr10	93351710	Silent	novel	Q1206Q	0.56
GBM	chr10	93351717	Missense_Mutation	novel	V1204D	0.19
GBM	chr10	93323086	Nonsense_Mutation	novel	Y1816*	0.06
GBM	chr10	93366489	Missense_Mutation	novel	S886A	0.08
GBM	chr10	93351715	Missense_Mutation	novel	L1205I	0.19
GBM	chr10	93351749	Silent	novel	D1193D	0.06
GBM	chr10	93366552	Missense_Mutation	novel	E865Q	0.15
GBM	chr10	93359894	Missense_Mutation	rs761738450	R1020Q	0.26
GBM	chr10	93306937	3'UTR	novel		0.15
HNSC	chr10	93399466	Frame_Shift_Del	novel	*T380Nfs8**	0.2
HNSC	chr10	93319884	Silent	rs181874899	I1862I	0.33
HNSC	chr10	93409713	Missense_Mutation	novel	E154K	0.24
HNSC	chr10	93310047	Silent	rs772809321	F2040F	0.12
HNSC	chr10	93329806	Missense_Mutation	novel	Q1614E	0.47
HNSC	chr10	93431486	Missense_Mutation	novel	K89N	0.27
HNSC	chr10	93408910	Silent	rs776333850	R202R	0.31
HNSC	chr10	93409699	Silent	novel	D158D	0.03
KICH	chr10	93408813	Silent	novel	R235R	0.62
KIRC	chr10	93316769	Silent	NA	P1881P	0.25
KIRC	chr10	93379912	Missense_Mutation	NA	S651N	0.23
KIRC	chr10	93333803	Silent	NA	Y1558Y	0.09
KIRC	chr10	93389045	Missense_Mutation	NA	E522D	0.16
KIRC	chr10	93310041	Silent	rs747850850	A2042A	0.08
KIRP	chr10	93316754	Frame_Shift_Del	novel	*I1887Yfs16**	0.36
KIRP	chr10	93306968	Missense_Mutation	rs372520132	V2061M	0.47
LAML	chr10	93373066	Missense_Mutation	novel	D774V	0.13
LAML	chr10	93329785	Missense_Mutation	novel	S1621P	0.04
LAML	chr10	93372970	Missense_Mutation	NA	S806F	0.06
LGG	chr10	93306901	3'UTR	novel		0.11
LGG	chr10	93310598	Missense_Mutation	rs180931942	D1979N	0.7
LGG	chr10	93313050	Silent	rs192250227	Y1953Y	0.06
LGG	chr10	93431441	Silent	novel	I104I	0.4
LGG	chr10	93323092	Silent	novel	D1814D	0.28
LGG	chr10	93313050	Silent	rs192250227	Y1953Y	0.04
LGG	chr10	93366434	Missense_Mutation	novel	G904A	0.05
LGG	chr10	93351751	Missense_Mutation	rs375965848	D1193N	0.2
LGG	chr10	93409574	Missense_Mutation	novel	Q200R	0.06
LIHC	chr10	93482223	5'Flank	novel		0.46
LIHC	chr10	93349839	Missense_Mutation	novel	N1351S	0.29
LIHC	chr10	93374829	Silent	novel	T745T	0.32
LIHC	chr10	93401439	Nonsense_Mutation	rs199504349	R366*	0.29
LIHC	chr10	93351258	Missense_Mutation	rs553662967	A1287V	0.22
LIHC	chr10	93313144	Missense_Mutation	novel	D1922V	0.27
LIHC	chr10	93356746	Missense_Mutation	rs181998538	R1075C	0.04
LIHC	chr10	93356737	Nonsense_Mutation	NA	R1078*	0.07
LUAD	chr10	93361558	Splice_Site	novel	X957_splice	0.21
LUAD	chr10	93409669	Frame_Shift_Del	novel	*P169Qfs17**	0.41
LUAD	chr10	93310021	Missense_Mutation	novel	P2049Q	0.09
LUAD	chr10	93313096	Missense_Mutation	rs764412531	A1938G	0.15
LUAD	chr10	93456927	Missense_Mutation	NA	K33N	0.08
LUAD	chr10	93396152	Silent	novel	G469G	0.21
LUAD	chr10	93313075	Missense_Mutation	NA	S1945F	0.34
LUAD	chr10	93389137	Nonsense_Mutation	NA	E492*	0.46
LUAD	chr10	93381321	Missense_Mutation	novel	A592P	0.05
LUAD	chr10	93347664	Missense_Mutation	rs572212231	R1401L	0.31
LUAD	chr10	93313081	Missense_Mutation	novel	Q1943L	0.57
LUAD	chr10	93353864	Missense_Mutation	rs761250319	C1143S	0.42
LUAD	chr10	93355673	Missense_Mutation	novel	T1120S	0.28
LUAD	chr10	93351821	Silent	NA	L1169L	0.12
LUAD	chr10	93306984	Missense_Mutation	NA	K2055N	0.15
LUAD	chr10	93366528	Missense_Mutation	NA	K873E	0.22
LUAD	chr10	93364015	Silent	rs769327487	E938E	0.32
LUAD	chr10	93374852	Missense_Mutation	novel	V738M	0.42
LUAD	chr10	93381354	Missense_Mutation	NA	H581N	0.27
LUAD	chr10	93392929	Missense_Mutation	novel	A482P	0.23
LUAD	chr10	93408911	Missense_Mutation	rs555479300	R202H	0.15
LUAD	chr10	93402346	Splice_Region	rs181979817	G292G	0.23
LUAD	chr10	93356829	Missense_Mutation	NA	D1047G	0.31
LUAD	chr10	93369645	Missense_Mutation	novel	M863I	0.2
LUAD	chr10	93369755	Missense_Mutation	rs149848851	G827R	0.18
LUAD	chr10	93356827	Nonsense_Mutation	novel	Q1048*	0.36
LUAD	chr10	93397449	Missense_Mutation	rs760821493	T410I	0.12
LUAD	chr10	93408911	Missense_Mutation	rs555479300	R202H	0.12
LUSC	chr10	93351270	Missense_Mutation	novel	P1283L	0.29
LUSC	chr10	93366538	Silent	novel	L869L	0.12
LUSC	chr10	93351469	Nonsense_Mutation	novel	G1256*	0.26
LUSC	chr10	93325841	Silent	rs772814311	Q1752Q	0.13
LUSC	chr10	93319904	Missense_Mutation	novel	P1856T	0.39
LUSC	chr10	93387906	Missense_Mutation	novel	G530V	0.71
LUSC	chr10	93333787	Missense_Mutation	NA	E1564Q	0.19
LUSC	chr10	93369760	Frame_Shift_Del	rs776353584	*N825Tfs12**	0.18
LUSC	chr10	93325862	Missense_Mutation	novel	R1745S	0.52
LUSC	chr10	93366481	Silent	NA	V888V	0.33
LUSC	chr10	93366482	Missense_Mutation	NA	V888G	0.33
LUSC	chr10	93337880	Missense_Mutation	novel	Y1458H	0.19
LUSC	chr10	93404034	Missense_Mutation	novel	G278W	0.39
LUSC	chr10	93306947	3'UTR	novel		0.32
LUSC	chr10	93363998	Frame_Shift_Del	NA	*G944Afs24**	0.08
OV	chr10	93364048	Silent	NA	H927H	0.36
OV	chr10	93329825	Missense_Mutation	novel	E1607D	0.06
OV	chr10	93381320	Missense_Mutation	novel	A592D	0.08
OV	chr10	93329715	Missense_Mutation	rs372110838	R1644Q	0.1
OV	chr10	93396202	Frame_Shift_Del	novel	V453*	0.11
OV	chr10	93356800	Missense_Mutation	rs748524728	I1057V	0.77
OV	chr10	93374917	Frame_Shift_Ins	NA	*T716Nfs20**	0.36
OV	chr10	93379868	Missense_Mutation	rs372369806	R666W	0.19
OV	chr10	93316737	In_Frame_Ins	novel	K1892delinsTE	0.04
PAAD	chr10	93323109	Missense_Mutation	novel	G1809R	0.13
PRAD	chr10	93329686	Missense_Mutation	rs200675152	G1654S	0.08
PRAD	chr10	93399493	Missense_Mutation	NA	D374N	0.31
PRAD	chr10	93310549	Missense_Mutation	NA	K1995M	0.22
PRAD	chr10	93313174	Frame_Shift_Del	novel	*P1912Lfs12**	0.58
PRAD	chr10	93343909	Missense_Mutation	novel	C1425R	0.52
PRAD	chr10	93373009	Missense_Mutation	rs766831576	A793V	0.46
READ	chr10	93361506	Missense_Mutation	NA	E974K	0.32
READ	chr10	93363968	Missense_Mutation	rs555130930	T954M	0.25
READ	chr10	93328906	Missense_Mutation	NA	G1663A	0.59
READ	chr10	93329745	Missense_Mutation	rs762684800	V1634A	0.23
READ	chr10	93409581	Missense_Mutation	NA	D198N	0.29
READ	chr10	93335961	Missense_Mutation	NA	S1508L	0.11
READ	chr10	93359917	Missense_Mutation	NA	E1012D	0.36
READ	chr10	93392956	Splice_Site	novel	X473_splice	0.39
READ	chr10	93313148	Missense_Mutation	novel	L1921V	0.29
READ	chr10	93329797	Missense_Mutation	NA	D1617Y	0.5
SARC	chr10	93397288	Frame_Shift_Del	novel	*P432Lfs7**	0.11
SARC	chr10	93397420	Missense_Mutation	novel	E420K	0.41
SARC	chr10	93408864	Missense_Mutation	novel	P218T	0.08
SKCM	chr10	93387857	Silent	NA	E546E	0.22
SKCM	chr10	93374838	Silent	rs761252874	S742S	0.24
SKCM	chr10	93356785	Missense_Mutation	NA	H1062Y	0.26
SKCM	chr10	93323327	Missense_Mutation	NA	P1768L	0.21
SKCM	chr10	93366440	Missense_Mutation	novel	P902L	0.14
SKCM	chr10	93356755	Missense_Mutation	rs201916621	R1072C	0.3
SKCM	chr10	93343891	Missense_Mutation	rs775970286	E1431K	0.4
SKCM	chr10	93351751	Missense_Mutation	rs375965848	D1193N	0.34
SKCM	chr10	93366546	Nonsense_Mutation	novel	Q867*	0.33
SKCM	chr10	93310034	Missense_Mutation	NA	L2045F	0.4
SKCM	chr10	93372970	Missense_Mutation	NA	S806F	0.06
SKCM	chr10	93399431	Silent	rs752348119	L394L	0.32
SKCM	chr10	93351550	Nonsense_Mutation	rs751178586	R1229*	0.07
SKCM	chr10	93397406	Silent	novel	V424V	0.3
SKCM	chr10	93337859	Missense_Mutation	NA	E1465K	0.23
SKCM	chr10	93316787	Silent	rs771670858	T1875T	0.13
SKCM	chr10	93313135	Missense_Mutation	rs199884146	P1925L	0.72
SKCM	chr10	93313136	Missense_Mutation	novel	P1925T	0.72
SKCM	chr10	93387822	Missense_Mutation	NA	S558L	0.47
SKCM	chr10	93328824	Silent	NA	I1690I	0.35
SKCM	chr10	93369678	Silent	rs780131150	F852F	0.35
SKCM	chr10	93409651	Silent	rs752115954	S174S	0.4
SKCM	chr10	93337911	Splice_Region	novel	E1447E	0.4
SKCM	chr10	93306871	3'UTR	novel		0.35
SKCM	chr10	93335943	Missense_Mutation	NA	P1514R	0.05
SKCM	chr10	93316814	Splice_Site	NA	X1867_splice	0.26
SKCM	chr10	93431517	Splice_Site	NA	X79_splice	0.29
SKCM	chr10	93359977	Splice_Region	NA	G992G	0.35
SKCM	chr10	93409661	Missense_Mutation	NA	G171E	0.33
SKCM	chr10	93343891	Missense_Mutation	rs775970286	E1431K	0.41
SKCM	chr10	93366395	Missense_Mutation	novel	R917K	0.39
SKCM	chr10	93325898	Silent	rs748134478	R1733R	0.82
SKCM	chr10	93351824	Silent	NA	F1168F	0.76
SKCM	chr10	93325903	Missense_Mutation	novel	L1732F	0.4
SKCM	chr10	93351732	Missense_Mutation	rs772413387	G1199E	0.24
SKCM	chr10	93333779	Silent	NA	Q1566Q	0.16
SKCM	chr10	93316780	Nonsense_Mutation	rs779005999	R1878*	0.27
SKCM	chr10	93351824	Silent	NA	F1168F	0.3
SKCM	chr10	93387906	Missense_Mutation	novel	G530E	0.09
SKCM	chr10	93387907	Missense_Mutation	novel	G530R	0.1
SKCM	chr10	93313074	Silent	NA	S1945S	0.36
SKCM	chr10	93381295	Silent	novel	G600G	0.32
SKCM	chr10	93347732	Silent	NA	I1378I	0.26
SKCM	chr10	93361509	Missense_Mutation	NA	W973R	0.37
SKCM	chr10	93402246	Missense_Mutation	novel	G326R	0.15
SKCM	chr10	93310625	Missense_Mutation	NA	L1970M	0.29
SKCM	chr10	93347641	Missense_Mutation	NA	E1409K	0.42
SKCM	chr10	93351242	Missense_Mutation	NA	M1292I	0.94
SKCM	chr10	93316760	Silent	NA	I1884I	0.13
SKCM	chr10	93387867	Missense_Mutation	rs780055290	T543I	0.39
SKCM	chr10	93387868	Missense_Mutation	novel	T543S	0.41
SKCM	chr10	93319898	Missense_Mutation	rs771346954	E1858K	0.51
SKCM	chr10	93323281	Frame_Shift_Del	novel	*A1785Pfs8**	0.41
SKCM	chr10	93323358	Missense_Mutation	novel	G1758R	0.63
SKCM	chr10	93351227	Silent	novel	I1297I	0.39
SKCM	chr10	93401473	Silent	novel	A354A	0.71
SKCM	chr10	93401474	Missense_Mutation	rs369657488	A354V	0.69
STAD	chr10	93409604	Missense_Mutation	rs374976050	R190Q	0.13
STAD	chr10	93381232	Silent	novel	R621R	0.29
STAD	chr10	93396155	Silent	rs754821669	G468G	0.25
STAD	chr10	93351820	Missense_Mutation	NA	H1170N	0.28
STAD	chr10	93366500	Missense_Mutation	novel	R882H	0.26
STAD	chr10	93397405	Missense_Mutation	rs771328774	V425I	0.35
STAD	chr10	93351454	Missense_Mutation	rs370780451	G1261R	0.27
STAD	chr10	93359892	Nonsense_Mutation	rs766517143	R1021*	0.08
STAD	chr10	93310110	Silent	rs200914729	I2019I	0.2
STAD	chr10	93347736	Missense_Mutation	novel	V1377A	0.07
STAD	chr10	93335995	Missense_Mutation	NA	F1497L	0.34
STAD	chr10	93404212	Frame_Shift_Del	novel	*F246Sfs6**	0.14
STAD	chr10	93351707	Silent	NA	N1207N	0.07
STAD	chr10	93310102	Missense_Mutation	rs754851421	R2022H	0.3
STAD	chr10	93408793	Frame_Shift_Del	NA	*F241Lfs11**	0.26
STAD	chr10	93310078	Missense_Mutation	rs761081912	G2030D	0.34
STAD	chr10	93401419	Missense_Mutation	NA	Q372H	0.29
STAD	chr10	93351205	Frame_Shift_Del	novel	*R1298Sfs3**	0.41
STAD	chr10	93351454	Missense_Mutation	rs370780451	G1261R	0.31
STAD	chr10	93364045	Silent	rs375118316	T928T	0.38
STAD	chr10	93392929	Missense_Mutation	novel	A482T	0.35
STAD	chr10	93319878	Silent	rs372599186	A1864A	0.31
STAD	chr10	93351240	Missense_Mutation	NA	V1293A	0.11
STAD	chr10	93359883	Missense_Mutation	NA	V1024F	0.1
STAD	chr10	93396142	Missense_Mutation	NA	D473N	0.41
STAD	chr10	93359868	Missense_Mutation	novel	K1029E	0.17
STAD	chr10	93319924	Missense_Mutation	NA	V1849A	0.25
STAD	chr10	93333868	Missense_Mutation	novel	A1537S	0.13
STAD	chr10	93349871	Silent	rs368099572	S1340S	0.4
STAD	chr10	93337895	Missense_Mutation	NA	W1453R	0.21
STAD	chr10	93347702	Silent	NA	V1388V	0.37
STAD	chr10	93397269	Frame_Shift_Del	novel	I438*	0.28
STAD	chr10	93356746	Missense_Mutation	rs181998538	R1075C	0.23
STAD	chr10	93361472	Missense_Mutation	NA	N985S	0.06
STAD	chr10	93369699	Silent	novel	V845V	0.06
STAD	chr10	93408793	Frame_Shift_Del	NA	*F241Lfs11**	0.31
STAD	chr10	93359838	Missense_Mutation	NA	A1039T	0.28
THCA	chr10	93361496	Missense_Mutation	NA	D977G	0.4
THYM	chr10	93337861	Missense_Mutation	novel	H1464R	0.09
UCEC	chr10	93351258	Missense_Mutation	rs553662967	A1287V	0.3
UCEC	chr10	93361554	Missense_Mutation	rs200007562	G958S	0.27
UCEC	chr10	93325834	Missense_Mutation	NA	I1755V	0.55
UCEC	chr10	93306784	3'UTR	novel		0.32
UCEC	chr10	93399476	Silent	NA	Q379Q	0.36
UCEC	chr10	93310103	Missense_Mutation	novel	R2022C	0.43
UCEC	chr10	93316789	Missense_Mutation	novel	T1875P	0.11
UCEC	chr10	93347761	Missense_Mutation	novel	Y1369H	0.15
UCEC	chr10	93431502	Missense_Mutation	rs200304153	A84V	0.29
UCEC	chr10	93325870	Missense_Mutation	NA	E1743K	0.48
UCEC	chr10	93373018	Missense_Mutation	NA	R790Q	0.11
UCEC	chr10	93313118	Missense_Mutation	novel	N1931D	0.42
UCEC	chr10	93329678	Silent	novel	P1656P	0.41
UCEC	chr10	93408803	Missense_Mutation	novel	N238T	0.37
UCEC	chr10	93349944	Missense_Mutation	novel	M1316T	0.46
UCEC	chr10	93316752	Missense_Mutation	novel	I1887T	0.38
UCEC	chr10	93356745	Missense_Mutation	rs766420687	R1075H	0.35
UCEC	chr10	93319931	Nonsense_Mutation	rs374378517	R1847*	0.56
UCEC	chr10	93333876	Missense_Mutation	novel	S1534N	0.52
UCEC	chr10	93355656	Silent	novel	N1125N	0.42
UCEC	chr10	93347672	Silent	novel	D1398D	0.11
UCEC	chr10	93323086	Silent	rs201878661	Y1816Y	0.1
UCEC	chr10	93351257	Silent	rs777576271	A1287A	0.47
UCEC	chr10	93404170	Missense_Mutation	novel	I260S	0.43
UCEC	chr10	93408792	Frame_Shift_Ins	rs759480107	D242*	0.4
UCEC	chr10	93401529	Missense_Mutation	rs201829735	R336C	0.38
UCEC	chr10	93351752	Silent	rs769006926	F1192F	0.21
UCEC	chr10	93372973	Missense_Mutation	NA	A805V	0.21
UCEC	chr10	93316750	Missense_Mutation	NA	W1888R	0.37
UCEC	chr10	93404197	Missense_Mutation	NA	M251T	0.26
UCEC	chr10	93347665	Missense_Mutation	novel	R1401C	0.5
UCEC	chr10	93310110	Silent	rs200914729	I2019I	0.26
UCEC	chr10	93319930	Missense_Mutation	NA	R1847Q	0.12
UCEC	chr10	93337902	Silent	novel	I1450I	0.05
UCEC	chr10	93355702	Missense_Mutation	NA	S1110N	0.29
UCEC	chr10	93361555	Splice_Region	NA	N957N	0.15
UCEC	chr10	93316743	Missense_Mutation	novel	N1890S	0.19
UCEC	chr10	93351290	Silent	novel	G1276G	0.24
UCEC	chr10	93329716	Nonsense_Mutation	NA	R1644*	0.38
UCEC	chr10	93351751	Missense_Mutation	rs375965848	D1193N	0.39
UCEC	chr10	93359903	Missense_Mutation	NA	T1017S	0.23
UCEC	chr10	93374897	Nonsense_Mutation	rs780482700	R723*	0.48
UCEC	chr10	93355651	Missense_Mutation	novel	P1127L	0.15
UCEC	chr10	93356790	Missense_Mutation	novel	K1060T	0.48
UCEC	chr10	93452075	Missense_Mutation	novel	D71Y	0.24
UCEC	chr10	93351226	Missense_Mutation	novel	R1298G	0.17
UCEC	chr10	93351499	Missense_Mutation	novel	P1246S	0.28
UCEC	chr10	93389108	Silent	novel	P501P	0.24
UCEC	chr10	93347632	Missense_Mutation	rs766655843	V1412I	0.46
UCEC	chr10	93356772	Missense_Mutation	novel	R1066H	0.41
UCEC	chr10	93426096	Silent	rs762163573	S136S	0.5
UCEC	chr10	93482316	5'Flank	novel		0.43
UCEC	chr10	93355721	Missense_Mutation	rs777087223	E1104K	0.47
UCEC	chr10	93306784	3'UTR	novel		0.39
UCEC	chr10	93347679	Missense_Mutation	rs781611138	R1396H	0.46
UCEC	chr10	93333768	Missense_Mutation	novel	N1570S	0.52
UCEC	chr10	93337854	Frame_Shift_Del	novel	*K1466Nfs20**	0.52
UCEC	chr10	93359838	Missense_Mutation	NA	A1039T	0.42
UCEC	chr10	93363997	Silent	rs757352331	G944G	0.26
UCEC	chr10	93373018	Missense_Mutation	NA	R790Q	0.48
UCEC	chr10	93452075	Missense_Mutation	novel	D71Y	0.6
UCEC	chr10	93351688	Nonsense_Mutation	novel	E1214*	0.16
UCEC	chr10	93456916	Missense_Mutation	novel	K37T	0.63
UCEC	chr10	93361466	Missense_Mutation	rs371303456	A987V	0.41
UCEC	chr10	93379907	Missense_Mutation	NA	R653C	0.29
UCEC	chr10	93329715	Missense_Mutation	rs372110838	R1644Q	0.39
UCEC	chr10	93351524	Silent	novel	K1237K	0.27
UCEC	chr10	93389124	Missense_Mutation	novel	V496A	0.24
UCEC	chr10	93396142	Missense_Mutation	novel	D473Y	0.29
UCEC	chr10	93409647	Frame_Shift_Ins	novel	*A176Nfs24**	0.05
UCEC	chr10	93366548	Missense_Mutation	novel	N866T	0.16
UCEC	chr10	93310041	Silent	rs747850850	A2042A	0.46
UCEC	chr10	93373018	Missense_Mutation	NA	R790Q	0.36
UCEC	chr10	93313035	Silent	rs145908975	G1958G	0.07
UCEC	chr10	93359839	Silent	rs750971795	T1038T	0.24
UCEC	chr10	93366549	Missense_Mutation	novel	N866D	0.19
UCEC	chr10	93431517	Splice_Site	novel	X79_splice	0.33
UCEC	chr10	93478312	Intron	novel		0.31
UCEC	chr10	93306783	3'UTR	novel		0.33
UCEC	chr10	93313091	Missense_Mutation	novel	L1940I	0.4
UCEC	chr10	93316805	Silent	novel	F1869F	0.55
UCEC	chr10	93347767	Missense_Mutation	rs774761394	E1367K	0.43
UCEC	chr10	93353829	Missense_Mutation	novel	D1155Y	0.51
UCEC	chr10	93359894	Missense_Mutation	rs761738450	R1020Q	0.22
UCEC	chr10	93408910	Silent	novel	R202R	0.4
UCEC	chr10	93361470	Missense_Mutation	rs748167650	R986G	0.59
UCEC	chr10	93349893	Missense_Mutation	novel	C1333Y	0.42
UCEC	chr10	93351545	Silent	NA	S1230S	0.47
UCEC	chr10	93323089	Silent	novel	I1815I	0.05
UCEC	chr10	93387867	Missense_Mutation	rs780055290	T543I	0.25
UCEC	chr10	93392956	Splice_Site	novel	X473_splice	0.06
UCEC	chr10	93452075	Missense_Mutation	novel	D71Y	0.05
UCEC	chr10	93399407	Silent	novel	S402S	0.29
UCEC	chr10	93409634	Missense_Mutation	rs140215599	R180Q	0.21
UCEC	chr10	93333254	Missense_Mutation	novel	Y1593F	0.27
UCEC	chr10	93478270	Intron	novel		0.36
UCEC	chr10	93356751	Missense_Mutation	rs755201286	R1073H	0.41
UCEC	chr10	93402318	Missense_Mutation	NA	L302V	0.44
UCEC	chr10	93320005	Missense_Mutation	novel	P1822H	0.38
UCEC	chr10	93333276	Frame_Shift_Ins	novel	*V1586Sfs3**	0.5
UCEC	chr10	93359932	Silent	novel	S1007S	0.43
UCEC	chr10	93409611	Missense_Mutation	novel	S188G	0.27
UCEC	chr10	93347768	Missense_Mutation	novel	E1366D	0.39
UCEC	chr10	93333277	Frame_Shift_Del	novel	*V1586Sfs23**	0.23
UCEC	chr10	93333311	Missense_Mutation	NA	C1574Y	0.46
UCEC	chr10	93399392	Frame_Shift_Ins	novel	*V408Gfs7**	0.38
UCEC	chr10	93306751	3'UTR	novel		0.38
UCEC	chr10	93351752	Missense_Mutation	NA	F1192L	0.49
UCEC	chr10	93310065	Silent	rs776068866	L2034L	0.41
UCEC	chr10	93355665	Silent	rs564047354	F1122F	0.31
UCEC	chr10	93306916	3'UTR	novel		0.32
UCEC	chr10	93335993	Missense_Mutation	NA	F1497L	0.31
UCEC	chr10	93355686	Silent	NA	K1115K	0.31
UCEC	chr10	93310165	Missense_Mutation	rs765341682	R2001Q	0.4
UCEC	chr10	93336025	Missense_Mutation	novel	N1487H	0.36
UCEC	chr10	93310586	Frame_Shift_Ins	novel	*A1983Rfs60**	0.01
UCEC	chr10	93337833	Missense_Mutation	novel	K1473N	0.22
UCEC	chr10	93381387	Nonsense_Mutation	rs375276858	R570*	0.31
UCEC	chr10	93401468	Missense_Mutation	rs758779569	R356Q	0.24
UCEC	chr10	93409705	Silent	novel	R156R	0.22
UCEC	chr10	93402260	Missense_Mutation	novel	F321C	0.42
UCEC	chr10	93408796	Missense_Mutation	novel	F240L	0.38
UCEC	chr10	93310567	Missense_Mutation	NA	E1989G	0.24
UCEC	chr10	93364013	Missense_Mutation	novel	S939N	0.12
UCEC	chr10	93374839	Missense_Mutation	NA	S742L	0.38
UCEC	chr10	93325940	Silent	rs762125809	H1719H	0.42
UCEC	chr10	93353867	Missense_Mutation	rs199761118	R1142H	0.38
UCEC	chr10	93359941	Silent	novel	K1004K	0.39
UCEC	chr10	93361466	Missense_Mutation	rs371303456	A987V	0.34
UCEC	chr10	93381387	Nonsense_Mutation	rs375276858	R570*	0.11
UCEC	chr10	93313036	Missense_Mutation	novel	G1958D	0.24
UCEC	chr10	93323109	Nonsense_Mutation	novel	G1809*	0.38
UCEC	chr10	93333303	Missense_Mutation	novel	Y1577H	0.26
UCEC	chr10	93333834	Missense_Mutation	novel	S1548N	0.39
UCS	chr10	93402875	Missense_Mutation	novel	V287F	0.24
UVM	chr10	93408846	Missense_Mutation	rs762578223	V224I	0.52
UVM	chr10	93431453	Silent	rs756928666	P100P	0.48
UVM	chr10	93351691	Missense_Mutation	novel	M1213L	0.4
UVM	chr10	93359880	Nonsense_Mutation	rs775643885	R1025*	0.21

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1	0.19593
CHOL	DEL	0.1667	0.048655
COAD	DEL	0.1707	9.4741e-07
MESO	DEL	0.2644	0.00015289
PAAD	DEL	0.1304	0.169
READ	DEL	0.2485	0.014135
THCA	DEL	0.018	0.011063
THYM	DEL	0.0325	0.10563
UCS	DEL	0.2857	0.1218

Survival Analysis

Cancer	P-value	Q-value
HNSC	0.0038	Kaplan-Meier Survival Analysis
SKCM	0.0058	Kaplan-Meier Survival Analysis
BRCA	0.038	Kaplan-Meier Survival Analysis
TGCT	0.047	Kaplan-Meier Survival Analysis
COAD	0.019	Kaplan-Meier Survival Analysis
PAAD	0.0002	Kaplan-Meier Survival Analysis
LAML	0.00012	Kaplan-Meier Survival Analysis
GBM	0.03	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.018	Kaplan-Meier Survival Analysis
UVM	0.046	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000138119 (Gene tree)
Gene ID: 26509
Gene Symbol: MYOF
Alias: KIAA1207|FER1L3
Full Name: myoferlin
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 176,058 bases
Position: chr10:93,306,429-93,482,486
Accession: 3656
RBP type: non-canonical RBP
Summary: Mutations in dysferlin, a protein associated with the plasma membrane, can cause muscle weakness that affects both proximal and distal muscles. The protein encoded by this gene is a type II membrane protein that is structurally similar to dysferlin. It is a member of the ferlin family and associates with both plasma and nuclear membranes. The protein contains C2 domains that play a role in calcium-mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. Two transcript variants encoding different isoforms have been found for this gene. Other possible variants have been detected, but their full-length nature has not been determined. [provided by RefSeq, Dec 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000475358	MYOF-207	483	-	-	- (aa)	-	-
ENST00000485212	MYOF-208	697	-	-	- (aa)	-	-
ENST00000488645	MYOF-209	627	-	-	- (aa)	-	-
ENST00000359263	MYOF-202	6719	XM_005269693	ENSP00000352208	2061 (aa)	XP_005269750	Q9NZM1
ENST00000474161	MYOF-206	462	-	-	- (aa)	-	-
ENST00000463743	MYOF-205	4812	-	ENSP00000432708	1177 (aa)	-	H0YD14
ENST00000371488	MYOF-203	763	-	ENSP00000360543	160 (aa)	-	Q9NZM1
ENST00000371489	MYOF-204	1519	-	ENSP00000360544	445 (aa)	-	Q9NZM1
ENST00000358334	MYOF-201	6680	XM_005269694	ENSP00000351094	2048 (aa)	XP_005269751	Q9NZM1

Gene Model

Click here to download ENSG00000138119's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000138119	Platelet Count	1.6010000E-005	-
ENSG00000138119	Blood Pressure	1.4518357E-005	-
ENSG00000138119	Platelet Function Tests	1.9760652E-007	-
ENSG00000138119	Platelet Function Tests	3.4479588E-006	-
ENSG00000138119	Platelet Function Tests	8.0763907E-006	-
ENSG00000138119	Platelet Function Tests	3.8621463E-006	-
ENSG00000138119	Platelet Function Tests	3.8621463E-006	-
ENSG00000138119	Platelet Function Tests	3.7219937E-006	-
ENSG00000138119	Platelet Function Tests	8.6892534E-006	-
ENSG00000138119	Platelet Function Tests	4.1681734E-006	-
ENSG00000138119	Platelet Function Tests	4.1681734E-006	-
ENSG00000138119	Platelet Function Tests	6.7968138E-006	-
ENSG00000138119	Platelet Function Tests	1.1632000E-005	-
ENSG00000138119	Platelet Function Tests	7.1090000E-007	-
ENSG00000138119	Platelet Function Tests	1.8881000E-005	-
ENSG00000138119	Platelet Function Tests	3.6871000E-006	-
ENSG00000138119	Platelet Function Tests	7.2979000E-007	-
ENSG00000138119	Platelet Function Tests	3.1085000E-006	-
ENSG00000138119	Platelet Function Tests	1.9196000E-006	-
ENSG00000138119	Platelet Function Tests	9.5516000E-007	-
ENSG00000138119	Platelet Function Tests	2.1436000E-007	-
ENSG00000138119	Dextroamphetamine	5.0163000E-005	-
ENSG00000138119	Blood Pressure	1.7784316E-006	-
ENSG00000138119	Arterial Pressure	2.9165284E-006	-
ENSG00000138119	Gastrointestinal Microbiome	9E-6	26528553

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000138119	rs787665	10	93312779	?	Gut microbiome composition (summer)	26528553	[0.55-1.31] unit increase	0.9299066	EFO_0007753

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000138119's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000138119	MYOF	100	93.994	ENSMUSG00000048612	Myof	100	93.994	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001778	plasma membrane repair	-	ISS	Process
GO:0005515	protein binding	17185750.24687993.	IPI	Function
GO:0005543	phospholipid binding	11959863.	IDA	Function
GO:0005543	phospholipid binding	-	ISS	Function
GO:0005635	nuclear envelope	10607832.	TAS	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0005901	caveola	-	ISS	Component
GO:0006071	glycerol metabolic process	-	IEA	Process
GO:0006936	muscle contraction	10607832.	TAS	Process
GO:0007520	myoblast fusion	-	IEA	Process
GO:0008015	blood circulation	10607832.	TAS	Process
GO:0016021	integral component of membrane	-	IEA	Component
GO:0030659	cytoplasmic vesicle membrane	-	IEA	Component
GO:0030947	regulation of vascular endothelial growth factor receptor signaling pathway	-	IEA	Process
GO:0031410	cytoplasmic vesicle	11959863.	IDA	Component
GO:0031965	nuclear membrane	-	IEA	Component
GO:0033292	T-tubule organization	-	IEA	Process
GO:0034605	cellular response to heat	-	IEA	Process
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0048747	muscle fiber development	-	IEA	Process
GO:0070062	extracellular exosome	19056867.21362503.23533145.	HDA	Component

EuRBPDB

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Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

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Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.