EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23444224	Functional genetic screens identify genes essential for tumor cell survival in head and neck and lung cancer.	Clin Cancer Res	2013 Apr 15	Martens-de Kemp SR	doi: 10.1158/1078-0432.CCR-12-2539
28011472	KIF11 Is Required for Spheroid Formation by Oesophageal and Colorectal Cancer Cells.	Anticancer Res	2017 Jan	Imai T	-
29115586	Characterization of KIF11 as a novel prognostic biomarker and therapeutic target for oral cancer.	Int J Oncol	2018 Jan	Daigo K	doi: 10.3892/ijo.2017.4181
25277178	Nuclear Eg5 (kinesin spindle protein) expression predicts docetaxel response and prostate cancer aggressiveness.	Oncotarget	2014 Sep 15	Wissing MD	-
21449971	Overexpression of Eg5 predicts unfavorable prognosis in non-muscle invasive bladder urothelial carcinoma.	Int J Urol	2011 Jun	Ding S	doi: 10.1111/j.1442-2042.2011.02751.x
19619321	KSP inhibitor ARRY-520 as a substitute for Paclitaxel in Type I ovarian cancer cells.	J Transl Med	2009 Jul 20	Kim KH	doi: 10.1186/1479-5876-7-63.
18512732	Effects of Eg5 knockdown on human prostate cancer xenograft growth and chemosensitivity.	Prostate	2008 Sep 1	Hayashi N	doi: 10.1002/pros.20783.
27459100	Overexpression of KIF11 in Gastric Cancer with Intestinal Mucin Phenotype.	Pathobiology	2017	Imai T	doi: 10.1159/000447303
27842896	Kinesin Family Member 11 mRNA Expression Predicts Prostate Cancer Aggressiveness.	Clin Genitourin Cancer	2017 Aug	Piao XM	doi: 10.1016/j.clgc.2016.10.005

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr10	92637452	Silent	novel	L689L	0.07
BLCA	chr10	92613422	Missense_Mutation	novel	D279N	0.22
BLCA	chr10	92645599	Missense_Mutation	NA	S835C	0.4
BLCA	chr10	92645499	Missense_Mutation	NA	D802N	0.17
BLCA	chr10	92606626	Missense_Mutation	novel	G73E	0.27
BLCA	chr10	92609146	Missense_Mutation	NA	L172V	0.2
BRCA	chr10	92628878	Missense_Mutation	NA	E430Q	0.48
BRCA	chr10	92645586	Missense_Mutation	novel	E831K	0.28
BRCA	chr10	92633718	Missense_Mutation	NA	V600F	0.28
BRCA	chr10	92637305	Missense_Mutation	novel	D666G	0.26
BRCA	chr10	92637199	Missense_Mutation	NA	D631N	0.37
BRCA	chr10	92606656	Missense_Mutation	NA	R83Q	0.29
BRCA	chr10	92628851	Nonsense_Mutation	novel	E421*	0.09
BRCA	chr10	92606362	Missense_Mutation	NA	D59N	0.32
CESC	chr10	92593441	Frame_Shift_Ins	novel	*V23Rfs7**	0.14
CESC	chr10	92633724	Missense_Mutation	NA	Q602E	0.36
CESC	chr10	92609020	Missense_Mutation	NA	D130H	0.33
CESC	chr10	92639799	Silent	rs147721514	L722L	0.39
CESC	chr10	92637480	Missense_Mutation	NA	E699K	0.61
CESC	chr10	92637531	Nonsense_Mutation	novel	Q716*	0.06
CESC	chr10	92630227	Missense_Mutation	NA	D453H	0.5
COAD	chr10	92633728	Missense_Mutation	NA	I603S	0.49
COAD	chr10	92648302	Missense_Mutation	novel	F880V	0.33
COAD	chr10	92653837	3'UTR	novel		0.08
COAD	chr10	92606715	Missense_Mutation	novel	A103S	0.27
COAD	chr10	92650507	Missense_Mutation	novel	P1010Q	0.04
COAD	chr10	92613107	Missense_Mutation	novel	V256I	0.17
COAD	chr10	92606690	Silent	novel	I94I	0.25
COAD	chr10	92630248	Nonsense_Mutation	NA	E460*	0.19
COAD	chr10	92593380	Missense_Mutation	NA	A2V	0.36
COAD	chr10	92609477	Frame_Shift_Ins	novel	*T223Sfs8**	0.14
COAD	chr10	92637397	Frame_Shift_Del	NA	*K673Rfs3**	0.12
ESCA	chr10	92593290	5'UTR	novel		0.89
ESCA	chr10	92648269	Missense_Mutation	rs149407589	R869C	0.08
ESCA	chr10	92613553	Missense_Mutation	novel	D322E	0.18
GBM	chr10	92653784	Silent	rs774629346	Q1053Q	0.26
GBM	chr10	92628864	Missense_Mutation	novel	K425I	0.51
GBM	chr10	92653741	Missense_Mutation	novel	T1039K	0.1
HNSC	chr10	92593428	Missense_Mutation	novel	N18S	0.22
HNSC	chr10	92616821	Missense_Mutation	rs780485814	A373T	0.16
KIRC	chr10	92637294	Missense_Mutation	NA	L662F	0.29
KIRC	chr10	92613115	Silent	rs749542461	I258I	0.2
KIRC	chr10	92645485	Missense_Mutation	NA	S797F	0.05
LGG	chr10	92639870	Missense_Mutation	novel	P746Q	0.4
LIHC	chr10	92609395	Missense_Mutation	NA	I195T	0.17
LIHC	chr10	92616784	Silent	NA	L360L	0.13
LIHC	chr10	92613502	Missense_Mutation	novel	R305S	0.45
LUAD	chr10	92621452	Missense_Mutation	rs751835131	Y399C	0.26
LUAD	chr10	92628849	Missense_Mutation	NA	V420E	0.16
LUAD	chr10	92633684	Silent	novel	S588S	0.2
LUAD	chr10	92630212	Missense_Mutation	NA	D448N	0.17
LUAD	chr10	92609024	Missense_Mutation	NA	P131L	0.4
LUSC	chr10	92621385	Missense_Mutation	NA	E377Q	0.43
LUSC	chr10	92632547	Missense_Mutation	novel	R519P	0.18
LUSC	chr10	92649905	Silent	NA	L947L	0.56
LUSC	chr10	92650449	Missense_Mutation	NA	L991V	0.61
LUSC	chr10	92607173	Missense_Mutation	novel	G108A	0.52
OV	chr10	92633785	Missense_Mutation	novel	Q622R	0.46
PAAD	chr10	92613417	Missense_Mutation	novel	A277V	0.18
PAAD	chr10	92621425	Missense_Mutation	novel	A390D	0.07
PRAD	chr10	92645493	Missense_Mutation	NA	H800Y	0.08
PRAD	chr10	92630303	Missense_Mutation	NA	E478G	0.11
PRAD	chr10	92653779	Missense_Mutation	NA	A1052P	0.12
PRAD	chr10	92593321	5'UTR	novel		0.4
PRAD	chr10	92609045	Missense_Mutation	novel	R138H	0.43
READ	chr10	92630248	Nonsense_Mutation	NA	E460*	0.25
READ	chr10	92645554	Missense_Mutation	NA	E820A	0.22
READ	chr10	92609096	Missense_Mutation	novel	S155L	0.26
READ	chr10	92653927	3'UTR	novel		0.3
READ	chr10	92648239	Missense_Mutation	NA	S859R	0.19
READ	chr10	92609062	Missense_Mutation	NA	F144I	0.35
SKCM	chr10	92650512	Missense_Mutation	novel	F1012I	0.25
SKCM	chr10	92632664	Missense_Mutation	novel	A558V	0.34
SKCM	chr10	92637503	Silent	novel	N706N	0.32
SKCM	chr10	92637504	Silent	novel	L707L	0.31
SKCM	chr10	92632531	Missense_Mutation	novel	H514Y	0.11
SKCM	chr10	92613455	Nonsense_Mutation	NA	Q290*	0.37
SKCM	chr10	92613599	Missense_Mutation	NA	P338S	0.38
SKCM	chr10	92649911	Missense_Mutation	NA	D949E	0.13
SKCM	chr10	92637212	Missense_Mutation	rs777764323	S635L	0.11
SKCM	chr10	92650458	Missense_Mutation	NA	E994K	0.07
STAD	chr10	92653668	Frame_Shift_Del	novel	*K1016Nfs52**	0.38
STAD	chr10	92649852	Frame_Shift_Del	novel	*S931Lfs11**	0.39
STAD	chr10	92645537	Missense_Mutation	NA	E814D	0.54
STAD	chr10	92606717	Splice_Site	rs527562872	X103_splice	0.21
STAD	chr10	92613399	Missense_Mutation	NA	N271S	0.23
STAD	chr10	92613088	Silent	novel	T249T	0.22
STAD	chr10	92628861	Frame_Shift_Del	novel	*I426Lfs8**	0.32
STAD	chr10	92649988	Splice_Site	NA	X974_splice	0.2
THCA	chr10	92609477	In_Frame_Ins	novel	T222_T223insSIRLVKTH	0.04
UCEC	chr10	92637397	Frame_Shift_Del	NA	*K673Rfs3**	0.23
UCEC	chr10	92628851	Nonsense_Mutation	novel	E421*	0.05
UCEC	chr10	92630340	Missense_Mutation	NA	E490D	0.25
UCEC	chr10	92632590	Missense_Mutation	novel	I533M	0.46
UCEC	chr10	92633673	Missense_Mutation	novel	A585T	0.3
UCEC	chr10	92645485	Missense_Mutation	NA	S797F	0.3
UCEC	chr10	92633737	Missense_Mutation	rs201259912	M606T	0.14
UCEC	chr10	92606375	Missense_Mutation	novel	R63M	0.06
UCEC	chr10	92639898	Missense_Mutation	novel	Q755H	0.38
UCEC	chr10	92639837	Missense_Mutation	novel	A735V	0.49
UCEC	chr10	92654920	3'UTR	novel		0.32
UCEC	chr10	92632489	Missense_Mutation	NA	L500F	0.16
UCEC	chr10	92637495	Missense_Mutation	novel	C704G	0.47
UCEC	chr10	92593428	Missense_Mutation	novel	N18S	0.09
UCEC	chr10	92630358	Silent	novel	A496A	0.2
UCEC	chr10	92645481	Nonsense_Mutation	NA	E796*	0.41
UCEC	chr10	92606682	Nonsense_Mutation	novel	E92*	0.38
UCEC	chr10	92654906	3'UTR	novel		0.43
UCEC	chr10	92630204	Missense_Mutation	novel	N445T	0.27
UCEC	chr10	92649883	Missense_Mutation	novel	R940K	0.35
UCEC	chr10	92609196	Silent	novel	P188P	0.29
UCEC	chr10	92654931	3'UTR	novel		0.38
UCEC	chr10	92606701	Missense_Mutation	novel	N98T	0.49
UCEC	chr10	92609133	Silent	novel	E167E	0.36
UCEC	chr10	92648316	Missense_Mutation	rs147512917	M884I	0.41
UCEC	chr10	92606296	Missense_Mutation	rs754165708	A37T	0.19
UCEC	chr10	92628869	Missense_Mutation	novel	G427S	0.38
UCEC	chr10	92637195	Missense_Mutation	novel	K629N	0.43
UCEC	chr10	92637397	Frame_Shift_Del	NA	*K673Rfs3**	0.31
UCEC	chr10	92645643	Splice_Site	NA	X849_splice	0.55
UCEC	chr10	92616815	Frame_Shift_Del	novel	*A373Lfs10**	0.22
UCEC	chr10	92633737	Missense_Mutation	rs201259912	M606T	0.49
UCEC	chr10	92606707	Missense_Mutation	novel	T100N	0.23
UCEC	chr10	92621396	Silent	novel	E380E	0.17
UCEC	chr10	92654824	3'UTR	novel		0.5
UCEC	chr10	92609198	Missense_Mutation	novel	R189H	0.49
UCEC	chr10	92621392	Missense_Mutation	novel	T379M	0.3
UCEC	chr10	92628866	Missense_Mutation	novel	I426L	0.44
UCEC	chr10	92637467	Missense_Mutation	novel	I694M	0.38
UCEC	chr10	92650460	Missense_Mutation	novel	E994D	0.39
UCEC	chr10	92637253	Frame_Shift_Del	novel	*K649Nfs3**	0.27
UCEC	chr10	92653824	3'UTR	novel		0.22
UCEC	chr10	92650411	Missense_Mutation	novel	V978E	0.26
UCEC	chr10	92606717	Splice_Site	rs527562872	X103_splice	0.17
UCEC	chr10	92648211	Splice_Site	novel	X850_splice	0.38
UCEC	chr10	92650410	Missense_Mutation	novel	V978I	0.25
UCEC	chr10	92628868	Missense_Mutation	NA	I426M	0.37
UCEC	chr10	92648373	Missense_Mutation	NA	K903N	0.57
UCEC	chr10	92648373	Missense_Mutation	NA	K903N	0.3
UCEC	chr10	92637397	Frame_Shift_Del	NA	*K673Rfs3**	0.21
UCEC	chr10	92609428	Missense_Mutation	NA	N206S	0.22
UCEC	chr10	92609447	Missense_Mutation	novel	Q212H	0.31
UCEC	chr10	92654935	3'UTR	novel		0.32
UCEC	chr10	92606711	Silent	novel	I101I	0.2
UCEC	chr10	92639828	Missense_Mutation	novel	R732K	0.41
UCEC	chr10	92616775	Missense_Mutation	novel	K357N	0.27
UCEC	chr10	92639865	Missense_Mutation	novel	Q744H	0.37
UCEC	chr10	92648364	Missense_Mutation	novel	E900D	0.41
UCEC	chr10	92650460	Silent	novel	E994E	0.47
UCEC	chr10	92630274	Silent	novel	L468L	0.34
UCEC	chr10	92633712	Missense_Mutation	novel	T598A	0.48
UCEC	chr10	92655027	3'UTR	novel		0.37
UCS	chr10	92609453	Missense_Mutation	novel	L214F	0.08
UCS	chr10	92648397	Silent	novel	C911C	0.25
UCS	chr10	92609510	Splice_Site	novel	X233_splice	0.31
UCS	chr10	92637438	Missense_Mutation	novel	N685D	0.38

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1	0.19593
CHOL	DEL	0.1667	0.048655
MESO	DEL	0.2529	0.00015289
PAAD	DEL	0.125	0.169
READ	DEL	0.2424	0.014135
THCA	DEL	0.02	0.011063
THYM	DEL	0.0325	0.10563
UCS	DEL	0.3036	0.1218

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0022	Kaplan-Meier Survival Analysis
KIRC	0.00081	Kaplan-Meier Survival Analysis
STAD	0.0078	Kaplan-Meier Survival Analysis
SARC	0.0021	Kaplan-Meier Survival Analysis
MESO	0.00023	Kaplan-Meier Survival Analysis
UCS	0.0088	Kaplan-Meier Survival Analysis
KIRP	0.0001	Kaplan-Meier Survival Analysis
PAAD	0.00045	Kaplan-Meier Survival Analysis
PCPG	0.026	Kaplan-Meier Survival Analysis
CESC	0.017	Kaplan-Meier Survival Analysis
KICH	0.023	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
CHOL	0.031	Kaplan-Meier Survival Analysis
LUAD	0.0001	Kaplan-Meier Survival Analysis
UVM	0.02	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000138160 (Gene tree)
Gene ID: 3832
Gene Symbol: KIF11
Alias: Eg5|HKSP|TRIP5|KNSL1
Full Name: kinesin family member 11
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 62,328 bases
Position: chr10:92,593,068-92,655,395
Accession: 6388
RBP type: non-canonical RBP
Summary: This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
25263096	The protective role of antifreeze protein 3 on the structure and function of mature mouse oocytes in vitrification.	Cryobiology	2014 Dec	Wen Y	doi: 10.1016/j.cryobiol.2014.09.006
20404347	Nucleophosmin/B23 inhibits Eg5-mediated microtubule depolymerization by inactivating its ATPase activity.	J Biol Chem	2010 Jun 18	Wang G	doi: 10.1074/jbc.M110.100396

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000260731	KIF11-201	4860	-	ENSP00000260731	1056 (aa)	-	P52732

Gene Model

Click here to download ENSG00000138160's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000138160	Hydrocortisone	2.9440000E-005	-
ENSG00000138160	Dehydroepiandrosterone	1.9140000E-005	-
ENSG00000138160	Blood Pressure	2.0213052E-005	-
ENSG00000138160	Blood Pressure	2.5195314E-006	-
ENSG00000138160	Arterial Pressure	1.0050030E-005	-
ENSG00000138160	Arterial Pressure	7.7929318E-007	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000138160	rs72811230	10	92648450	?	Tuberculosis	28928442	[0.13-0.29] unit increase	0.2065	EFO_0008407

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000138160's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000138160	KIF11	50	49.630	FBgn0004378	Klp61F	90	35.785	Drosophila_melanogaster

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000278	mitotic cell cycle	8548803.	TAS	Process
GO:0000922	spindle pole	14718566.	IDA	Component
GO:0003777	microtubule motor activity	21873635.	IBA	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005819	spindle	19001501.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005871	kinesin complex	21873635.	IBA	Component
GO:0005874	microtubule	21873635.	IBA	Component
GO:0005874	microtubule	21525035.	IDA	Component
GO:0005876	spindle microtubule	21873635.	IBA	Component
GO:0005876	spindle microtubule	14718566.	IDA	Component
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	-	TAS	Process
GO:0007018	microtubule-based movement	21873635.	IBA	Process
GO:0007018	microtubule-based movement	-	TAS	Process
GO:0007051	spindle organization	14718566.	IMP	Process
GO:0007052	mitotic spindle organization	8548803.	TAS	Process
GO:0007100	mitotic centrosome separation	-	IEA	Process
GO:0008017	microtubule binding	21873635.	IBA	Function
GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed	21873635.	IBA	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0016887	ATPase activity	21873635.	IBA	Function
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	-	TAS	Process
GO:0019901	protein kinase binding	19001501.	IPI	Function
GO:0032991	protein-containing complex	17707232.	IPI	Component
GO:0046602	regulation of mitotic centrosome separation	15843429.	IMP	Process
GO:0051301	cell division	-	IEA	Process
GO:0072686	mitotic spindle	-	IDA	Component
GO:0090307	mitotic spindle assembly	21873635.	IBA	Process
GO:0090307	mitotic spindle assembly	19001501.	IDA	Process
GO:0090307	mitotic spindle assembly	15843429.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.