EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
30277841	Assessment of CEP55, PLK1 and FOXM1 expression in patients with bladder cancer in comparison with healthy individuals.	Cancer Invest	2018	Seyedabadi S	doi: 10.1080/07357907.2018.1514504
26902787	Lentivirus-mediated knockdown of CEP55 suppresses cell proliferation of breast cancer cells.	Biosci Trends	2016 Feb	Wang Y	doi: 10.5582/bst.2016.01010
20400365	Downstream targets of FOXM1: CEP55 and HELLS are cancer progression markers of head and neck squamous cell carcinoma.	Oral Oncol	2010 Jul	Waseem A	doi: 10.1016/j.oraloncology.2010.03.022
26615423	Upregulation of centrosomal protein 55 is associated with unfavorable prognosis and tumor invasion in epithelial ovarian carcinoma.	Tumour Biol	2016 May	Zhang W	doi: 10.1007/s13277-015-4419-6
29750778	Correlations Between mRNA Levels of Centrosomal Protein 55 (CEP55) and Clinical Features of Patients with Lung Cancer.	Med Sci Monit	2018 May 11	Ma XP	doi: 10.12659/MSM.907266.
28724890	Centrosomal protein 55 activates NF-??B signalling and promotes pancreatic cancer cells aggressiveness.	Sci Rep	2017 Jul 19	Peng T	doi: 10.1038/s41598-017-06132-z.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr10	93528007	Missense_Mutation	NA	E417K	0.31
BLCA	chr10	93516951	Missense_Mutation	novel	E232D	0.39
BLCA	chr10	93507030	Missense_Mutation	NA	H168D	0.22
BLCA	chr10	93503342	Missense_Mutation	novel	R138L	0.12
BLCA	chr10	93515438	Missense_Mutation	novel	D188N	0.24
BLCA	chr10	93515537	Missense_Mutation	NA	K221E	0.21
BLCA	chr10	93516948	Silent	novel	E231E	0.7
BLCA	chr10	93528057	Silent	novel	L433L	0.31
BLCA	chr10	93518889	Missense_Mutation	rs752455356	Y336H	0.61
BLCA	chr10	93517161	Silent	novel	E302E	0.29
BRCA	chr10	93519744	Silent	NA	Q376Q	0.2
BRCA	chr10	93500109	Frame_Shift_Del	novel	*S21Yfs18**	0.16
BRCA	chr10	93528093	Frame_Shift_Ins	novel	*Q446Pfs6**	0.36
BRCA	chr10	93516987	Frame_Shift_Del	NA	*D247Ifs9**	0.29
CESC	chr10	93500120	Silent	rs765024195	S23S	0.44
CESC	chr10	93503155	Missense_Mutation	NA	Q76E	0.16
COAD	chr10	93503296	Nonsense_Mutation	novel	E123delinsVS**	0.05
COAD	chr10	93517171	Missense_Mutation	NA	K306Q	0.35
COAD	chr10	93528168	3'UTR	novel		0.39
COAD	chr10	93515500	Missense_Mutation	novel	K208N	0.06
COAD	chr10	93515493	Missense_Mutation	novel	E206G	0.23
COAD	chr10	93516987	Frame_Shift_Del	NA	*D247Ifs9**	0.25
COAD	chr10	93503231	Missense_Mutation	NA	L101P	0.39
COAD	chr10	93517052	Missense_Mutation	rs749800886	R266Q	0.13
COAD	chr10	93503208	Silent	NA	A93A	0.16
COAD	chr10	93517052	Missense_Mutation	rs749800886	R266Q	0.19
COAD	chr10	93503252	Missense_Mutation	NA	T108R	0.23
ESCA	chr10	93527969	Missense_Mutation	novel	A404V	0.06
GBM	chr10	93516970	Missense_Mutation	rs767877691	D239N	0.38
GBM	chr10	93519770	Missense_Mutation	rs578017409	R385Q	0.29
GBM	chr10	93516941	Missense_Mutation	novel	L229R	0.71
HNSC	chr10	93517073	Missense_Mutation	novel	Q273L	0.17
HNSC	chr10	93528051	Silent	rs747409579	A431A	0.25
HNSC	chr10	93517006	Missense_Mutation	novel	E251K	0.1
LGG	chr10	93516970	Missense_Mutation	rs767877691	D239N	0.27
LIHC	chr10	93500132	Missense_Mutation	NA	L27F	0.8
LUAD	chr10	93517123	Missense_Mutation	novel	D290H	0.16
LUAD	chr10	93519688	Missense_Mutation	rs777977691	A358T	0.27
LUAD	chr10	93503301	Missense_Mutation	novel	E124D	0.31
LUAD	chr10	93528216	3'UTR	novel		0.2
LUAD	chr10	93528217	3'UTR	novel		0.2
LUAD	chr10	93515542	Missense_Mutation	novel	K222N	0.08
LUAD	chr10	93517159	Nonsense_Mutation	NA	E302*	0.24
LUSC	chr10	93500119	Missense_Mutation	NA	S23F	0.41
LUSC	chr10	93517185	Silent	novel	E310E	0.16
LUSC	chr10	93515427	Missense_Mutation	novel	W184L	0.34
LUSC	chr10	93528219	3'UTR	novel		0.5
LUSC	chr10	93517067	Missense_Mutation	NA	E271G	0.46
OV	chr10	93528181	3'UTR	novel		0.07
READ	chr10	93503145	Missense_Mutation	novel	K72N	0.4
READ	chr10	93519720	Silent	rs370915787	L368L	0.4
SKCM	chr10	93503119	Nonsense_Mutation	rs146596670	R64*	0.21
SKCM	chr10	93515524	Silent	novel	L216L	0.32
SKCM	chr10	93527959	Missense_Mutation	novel	H401Y	0.42
SKCM	chr10	93517004	Missense_Mutation	NA	V250A	0.27
SKCM	chr10	93519763	Missense_Mutation	NA	E383K	0.2
SKCM	chr10	93500119	Missense_Mutation	NA	S23F	0.8
STAD	chr10	93500139	Frame_Shift_Del	novel	L30*	0.09
STAD	chr10	93515445	Missense_Mutation	novel	Q190P	0.08
STAD	chr10	93516987	Frame_Shift_Del	NA	*D247Ifs9**	0.37
STAD	chr10	93528068	Missense_Mutation	NA	L437P	0.15
STAD	chr10	93517075	Missense_Mutation	NA	K274E	0.1
UCEC	chr10	93516970	Missense_Mutation	rs767877691	D239N	0.34
UCEC	chr10	93503296	Missense_Mutation	novel	E123K	0.4
UCEC	chr10	93500120	Silent	rs765024195	S23S	0.27
UCEC	chr10	93517185	Missense_Mutation	NA	E310D	0.42
UCEC	chr10	93500073	Missense_Mutation	novel	D8Y	0.09
UCEC	chr10	93528253	3'UTR	novel		0.5
UCEC	chr10	93506987	Splice_Site	novel	X154_splice	0.28
UCEC	chr10	93517236	Silent	novel	E327E	0.57
UCEC	chr10	93503251	Missense_Mutation	novel	T108P	0.18
UCEC	chr10	93528240	3'UTR	novel		0.29
UCEC	chr10	93519863	Intron	novel		0.07
UCEC	chr10	93516970	Missense_Mutation	rs767877691	D239N	0.26
UCEC	chr10	93517196	Missense_Mutation	novel	A314V	0.27
UCEC	chr10	93515535	Frame_Shift_Ins	novel	*P223Afs2**	0.3
UCEC	chr10	93516970	Missense_Mutation	rs767877691	D239N	0.46
UCEC	chr10	93517088	Missense_Mutation	novel	N278T	0.5
UCEC	chr10	93515507	Missense_Mutation	NA	T211A	0.27
UCEC	chr10	93519757	Missense_Mutation	NA	L381I	0.81
UCEC	chr10	93515479	Missense_Mutation	novel	K201N	0.28
UCEC	chr10	93503342	Missense_Mutation	rs370361002	R138Q	0.39
UCEC	chr10	93516986	Frame_Shift_Ins	novel	*D247Rfs3**	0.37
UCEC	chr10	93519684	Missense_Mutation	novel	M356I	0.24
UCEC	chr10	93528227	3'UTR	novel		0.4
UCEC	chr10	93515502	Missense_Mutation	rs199775989	T209M	0.24
UCEC	chr10	93516987	Frame_Shift_Del	NA	*D247Ifs9**	0.38
UCEC	chr10	93503308	Missense_Mutation	rs199894468	V127I	0.33
UCEC	chr10	93517065	Nonsense_Mutation	novel	*N278Kfs2**	0.04
UCEC	chr10	93517185	Missense_Mutation	NA	E310D	0.38
UCEC	chr10	93519743	Missense_Mutation	novel	Q376R	0.53
UCEC	chr10	93528162	3'UTR	novel		0.37
UCEC	chr10	93519779	Missense_Mutation	novel	R388I	0.27
UCEC	chr10	93503174	Missense_Mutation	novel	K82T	0.37
UCEC	chr10	93516970	Missense_Mutation	rs767877691	D239N	0.2
UCEC	chr10	93517164	Missense_Mutation	novel	K303N	0.21
UCEC	chr10	93503185	Nonsense_Mutation	rs141458677	R86*	0.34
UCS	chr10	93503119	Nonsense_Mutation	rs146596670	R64*	0.45
UCS	chr10	93503342	Missense_Mutation	rs370361002	R138Q	0.32

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1	0.19593
CHOL	DEL	0.1667	0.048655
COAD	DEL	0.1707	9.4741e-07
MESO	DEL	0.2644	0.00015289
PAAD	DEL	0.1304	0.169
READ	DEL	0.2485	0.014135
THCA	DEL	0.018	0.011063
THYM	DEL	0.0325	0.10563
UCS	DEL	0.2857	0.1218

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0074	Kaplan-Meier Survival Analysis
KIRC	0.00011	Kaplan-Meier Survival Analysis
STAD	0.00075	Kaplan-Meier Survival Analysis
MESO	0.00015	Kaplan-Meier Survival Analysis
ACC	0.00017	Kaplan-Meier Survival Analysis
LUSC	0.013	Kaplan-Meier Survival Analysis
KIRP	0.00013	Kaplan-Meier Survival Analysis
PAAD	0.00011	Kaplan-Meier Survival Analysis
PCPG	0.034	Kaplan-Meier Survival Analysis
CESC	0.017	Kaplan-Meier Survival Analysis
KICH	0.0015	Kaplan-Meier Survival Analysis
LIHC	0.00011	Kaplan-Meier Survival Analysis
LUAD	0.0001	Kaplan-Meier Survival Analysis
UVM	0.016	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000138180 (Gene tree)
Gene ID: 55165
Gene Symbol: CEP55
Alias: FLJ10540|CT111|C10orf3
Full Name: centrosomal protein 55
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 32,483 bases
Position: chr10:93,496,612-93,529,094
Accession: 1161
RBP type: non-canonical RBP
Summary: (Centrosomal Protein 55) is a Protein Coding gene. Diseases associated with CEP55 include Multinucleated Neurons, Anhydramnios, Renal Dysplasia, Cerebellar Hypoplasia, And Hydranencephaly and Meckel Syndrome, Type 1. Among its related pathways are DNA Damage and Cytoskeletal Signaling.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000445435	CEP55-202	747	-	ENSP00000389150	208 (aa)	-	H0Y432
ENST00000496302	CEP55-203	710	-	-	- (aa)	-	-
ENST00000371485	CEP55-201	2638	XM_011539918	ENSP00000360540	464 (aa)	XP_011538220	Q53EZ4

Gene Model

Click here to download ENSG00000138180's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000138180	Glomerular Filtration Rate	1.2719533E-005	-
ENSG00000138180	Glomerular Filtration Rate	8.7220442E-005	-
ENSG00000138180	Glomerular Filtration Rate	8.1242576E-005	-
ENSG00000138180	Platelet Function Tests	4.5925000E-006	-
ENSG00000138180	Platelet Function Tests	1.4019000E-006	-
ENSG00000138180	Platelet Function Tests	1.5923000E-005	-
ENSG00000138180	Platelet Function Tests	1.5923000E-005	-
ENSG00000138180	Platelet Function Tests	1.4892000E-005	-
ENSG00000138180	Bronchodilator Agents	3E-6	26634245
ENSG00000138180	Lung Volume Measurements	3E-6	26634245
ENSG00000138180	Bronchodilator Agents	3E-6	26634245
ENSG00000138180	Lung Volume Measurements	3E-6	26634245

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000138180	rs10882258	10	93515133	?	Lobe attachment (rater-scored or self-reported)	29198719			EFO_0007667

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000138180's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000281	mitotic cytokinesis	21873635.	IBA	Process
GO:0000281	mitotic cytokinesis	19638580.	IGI	Process
GO:0005515	protein binding	16189514.17853893.18940611.19549727.20176808.21516116.25416956.25910212.26638075.26871637.27107012.	IPI	Function
GO:0005813	centrosome	20186884.21399614.	IDA	Component
GO:0005814	centriole	-	IEA	Component
GO:0005815	microtubule organizing center	-	IDA	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0006997	nucleus organization	20616062.	IMP	Process
GO:0007080	mitotic metaphase plate congression	20616062.	IMP	Process
GO:0014066	regulation of phosphatidylinositol 3-kinase signaling	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0030496	midbody	21873635.	IBA	Component
GO:0030496	midbody	20186884.21310966.28264986.	IDA	Component
GO:0032154	cleavage furrow	-	IEA	Component
GO:0045171	intercellular bridge	-	IEA	Component
GO:0045184	establishment of protein localization	21873635.	IBA	Process
GO:0045184	establishment of protein localization	23045692.	IMP	Process
GO:0061952	midbody abscission	20616062.	IMP	Process
GO:0072001	renal system development	28264986.	IMP	Process
GO:0090543	Flemming body	18641129.	IDA	Component
GO:1904888	cranial skeletal system development	28264986.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.