EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28176245	Effect of annexin A7 suppression on the apoptosis of gastric cancer cells.	Mol Cell Biochem	2017 May	Ye W	doi: 10.1007/s11010-016-2934-4
20190808	Role of multi-hnRNP nuclear complex in regulation of tumor suppressor ANXA7 in prostate cancer cells.	Oncogene	2010 Apr 29	Torosyan Y	doi: 10.1038/onc.2010.2
24865424	Lineage-specific splicing of a brain-enriched alternative exon promotes glioblastoma progression.	J Clin Invest	2014 Jul	Ferrarese R	doi: 10.1172/JCI68836
17018618	Distinct effects of annexin A7 and p53 on arachidonate lipoxygenation in prostate cancer cells involve 5-lipoxygenase transcription.	Cancer Res	2006 Oct 1	Torosyan Y	-
19602687	Monosomy of chromosome 10 associated with dysregulation of epidermal growth factor signaling in glioblastomas.	JAMA	2009 Jul 15	Yadav AK	doi: 10.1001/jama.2009.1022.
27807828	ANXA7-GTPase as Tumor Suppressor: Mechanisms and Therapeutic Opportunities.	Methods Mol Biol	2017	Leighton X	-
25400735	Expression of annexin A7 and its clinical significance in differentiation and metastasis of gastric carcinoma.	Int J Clin Exp Pathol	2014 Sep 15	Yuan HF	-
18449914	The significance of ANXA7 expression and its correlation with poor cellular differentiation and enhanced metastatic potential of gastric cancer.	J Surg Oncol	2008 Jun 1	Hsu PI	doi: 10.1002/jso.21046.
25339368	microRNA-155 promotes the proliferation of prostate cancer cells by targeting annexin 7.	Mol Med Rep	2015 Jan	Cai ZK	doi: 10.3892/mmr.2014.2744
29970503	High ANXA7 Potentiates Eucalyptol Toxicity in Hormone-refractory Prostate Cancer.	Anticancer Res	2018 Jul	Leighton X	doi: 10.21873/anticanres.12667.
30321230	Tissue microarray analysis delineate potential prognostic role of Annexin A7 in prostate cancer progression.	PLoS One	2018 Oct 15	Leighton X	doi: 10.1371/journal.pone.0205837

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr10	73376218	Splice_Site	novel	X449_splice	0.18
BLCA	chr10	73388333	Missense_Mutation	rs370894790	R195C	0.6
BLCA	chr10	73378977	Nonsense_Mutation	novel	Y426*	0.26
BLCA	chr10	73398201	Missense_Mutation	novel	G80E	0.42
BLCA	chr10	73376218	Splice_Site	novel	X449_splice	0.22
BRCA	chr10	73376157	Missense_Mutation	rs182716602	M469V	0.3
BRCA	chr10	73387731	Silent	NA	Q219Q	0.38
CESC	chr10	73383606	Missense_Mutation	rs769213073	D262N	0.2
CESC	chr10	73388360	Missense_Mutation	rs142735473	D186N	0.38
COAD	chr10	73380195	Missense_Mutation	rs770697765	R331C	0.41
COAD	chr10	73379921	Missense_Mutation	rs778139210	R397C	0.42
COAD	chr10	73397171	Silent	novel	P121P	0.33
COAD	chr10	73376076	3'UTR	NA		0.58
COAD	chr10	73379909	Missense_Mutation	rs765172371	G401R	0.31
COAD	chr10	73376187	Missense_Mutation	rs146521289	A459T	0.44
ESCA	chr10	73383326	Missense_Mutation	novel	R278L	0.19
GBM	chr10	73378912	Missense_Mutation	novel	E448G	0.31
GBM	chr10	73383613	Silent	rs113051613	T259T	0.24
HNSC	chr10	73397188	Missense_Mutation	NA	G116C	0.19
HNSC	chr10	73380063	Nonsense_Mutation	NA	Q375*	0.23
HNSC	chr10	73378967	Nonsense_Mutation	novel	K430*	0.1
HNSC	chr10	73398348	Missense_Mutation	novel	Q31R	0.4
KIRC	chr10	73396063	Missense_Mutation	NA	S161F	0.24
KIRP	chr10	73396538	Missense_Mutation	novel	Q139P	0.41
KIRP	chr10	73387727	Missense_Mutation	novel	Q221K	0.27
LAML	chr10	73380072	Missense_Mutation	novel	S372C	0.12
LGG	chr10	73388364	Missense_Mutation	NA	N184K	0.32
LIHC	chr10	73387705	Missense_Mutation	NA	K228M	0.13
LIHC	chr10	73387694	Missense_Mutation	rs750509037	G232S	0.17
LUAD	chr10	73398205	Missense_Mutation	novel	G79W	0.18
LUAD	chr10	73380084	Missense_Mutation	novel	L368F	0.23
LUAD	chr10	73387738	Missense_Mutation	rs369628555	N217S	0.26
LUSC	chr10	73398222	Missense_Mutation	novel	P73L	0.25
LUSC	chr10	73398243	Missense_Mutation	novel	Y66F	0.26
LUSC	chr10	73383315	Missense_Mutation	novel	E282Q	0.1
LUSC	chr10	73398227	Silent	NA	G71G	0.16
LUSC	chr10	73379010	Silent	novel	L415L	0.24
LUSC	chr10	73387744	Missense_Mutation	rs770294831	R215H	0.16
OV	chr10	73396547	Missense_Mutation	NA	P136R	0.27
OV	chr10	73397158	Splice_Site	novel	X120_splice	0.13
OV	chr10	73378944	Silent	novel	S437S	0.04
PAAD	chr10	73397172	Missense_Mutation	novel	P121L	0.31
PRAD	chr10	73380109	Silent	rs138551538	T359T	0.11
READ	chr10	73383606	Missense_Mutation	rs769213073	D262N	0.34
READ	chr10	73380194	Missense_Mutation	rs10159690	R331H	0.59
READ	chr10	73376060	3'UTR	novel		0.33
SARC	chr10	73396527	Missense_Mutation	novel	P143A	0.58
SKCM	chr10	73383283	Silent	rs139287762	I292I	0.2
SKCM	chr10	73398241	Missense_Mutation	NA	P67S	0.41
SKCM	chr10	73376170	Silent	NA	K464K	0.52
SKCM	chr10	73397268	Missense_Mutation	NA	P89L	0.13
SKCM	chr10	73398358	Missense_Mutation	novel	P28S	0.32
SKCM	chr10	73398291	Missense_Mutation	NA	P50L	0.59
SKCM	chr10	73383662	Frame_Shift_Del	NA	L243*	0.36
SKCM	chr10	73397254	Nonsense_Mutation	novel	G94*	0.31
SKCM	chr10	73397255	Missense_Mutation	novel	F93L	0.33
STAD	chr10	73400826	Missense_Mutation	novel	Y11H	0.17
STAD	chr10	73383304	Silent	novel	C285C	0.29
STAD	chr10	73383246	Nonsense_Mutation	rs763704857	R305*	0.19
THCA	chr10	73396105	Nonsense_Mutation	novel	*N147Tfs5**	0.15
THCA	chr10	73378968	Missense_Mutation	novel	M429I	0.4
UCEC	chr10	73383237	Missense_Mutation	rs760138152	E308Q	0.24
UCEC	chr10	73388333	Missense_Mutation	rs370894790	R195C	0.28
UCEC	chr10	73383198	Missense_Mutation	rs763284965	R321C	0.11
UCEC	chr10	73376187	Missense_Mutation	rs146521289	A459T	0.3
UCEC	chr10	73380083	Missense_Mutation	novel	L368R	0.12
UCEC	chr10	73387769	Missense_Mutation	novel	A207T	0.35
UCEC	chr10	73376053	3'UTR	novel		0.22
UCEC	chr10	73376050	3'UTR	novel		0.41
UCEC	chr10	73379945	Nonsense_Mutation	rs772606696	R389*	0.28
UCEC	chr10	73376187	Missense_Mutation	rs146521289	A459T	0.48
UCEC	chr10	73398184	Missense_Mutation	rs370055787	G86R	0.53
UCEC	chr10	73380200	Missense_Mutation	novel	G329E	0.32
UCEC	chr10	73380109	Silent	rs138551538	T359T	0.25
UCEC	chr10	73396100	Missense_Mutation	novel	D149Y	0.35
UCEC	chr10	73375993	3'UTR	novel		0.45
UCEC	chr10	73388360	Missense_Mutation	rs142735473	D186N	0.43
UCEC	chr10	73376060	3'UTR	novel		0.36
UCEC	chr10	73396063	Missense_Mutation	novel	S161Y	0.13
UCEC	chr10	73383327	Missense_Mutation	rs775887772	R278C	0.5
UCEC	chr10	73398356	Silent	NA	P28P	0.3
UCEC	chr10	73383347	Splice_Site	novel	X272_splice	0.63
UCEC	chr10	73397162	Splice_Site	NA	X124_splice	0.45
UCEC	chr10	73378918	Missense_Mutation	NA	R446Q	0.41
UCEC	chr10	73396045	Missense_Mutation	novel	E167G	0.05
UCEC	chr10	73397226	Missense_Mutation	novel	S103Y	0.26
UCEC	chr10	73387744	Missense_Mutation	rs770294831	R215H	0.2
UCEC	chr10	73388347	Missense_Mutation	novel	D190V	0.22
UCEC	chr10	73396087	Missense_Mutation	novel	S153F	0.13
UCEC	chr10	73397204	Silent	NA	S110S	0.24
UCEC	chr10	73375997	3'UTR	novel		0.47
UCEC	chr10	73398254	Silent	rs375225097	A62A	0.55

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1	0.19593
READ	AMP	0.0485	0.13718
THCA	DEL	0.022	0.011063

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
SARC	0.027	Kaplan-Meier Survival Analysis
UCS	0.05	Kaplan-Meier Survival Analysis
SKCM	0.00011	Kaplan-Meier Survival Analysis
KIRP	0.0018	Kaplan-Meier Survival Analysis
BLCA	0.027	Kaplan-Meier Survival Analysis
UVM	0.0025	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000138279 (Gene tree)
Gene ID: 310
Gene Symbol: ANXA7
Alias: ANX7
Full Name: annexin A7
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 38,983 bases
Position: chr10:73,375,101-73,414,083
Accession: 545
RBP type: non-canonical RBP
Summary: Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins.The Annexin VII gene contains 14 exons and spans approximately 34 kb of DNA. An alternatively spliced cassette exon results in two mRNA transcripts of 2.0 and 2.4 kb which are predicted to generate two protein isoforms differing in their N-terminal domain. The alternative splicing event is tissue specific and the mRNA containing the cassette exon is prevalent in brain, heart and skeletal muscle. The transcripts also differ in their 3'-non coding regions by the use of two alternative poly(A) signals. Annexin VII encodes a protein with a molecular weight of approximately 51 kDa with a unique, highly hydrophobic N-terminal domain of 167 amino acids and a conserved C-terminal region of 299 amino acids. The latter domain is composed of alternating hydrophobic and hydrophilic segments. Structural analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties, including voltage-sensitive calcium channel activity, ion selectivity and membrane fusion. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000372921	ANXA7-202	2452	XM_017016163	ENSP00000362012	466 (aa)	XP_016871652	P20073
ENST00000463788	ANXA7-204	739	-	-	- (aa)	-	-
ENST00000372919	ANXA7-201	2174	XM_017016162	ENSP00000362010	488 (aa)	XP_016871651	P20073
ENST00000394847	ANXA7-203	648	-	ENSP00000378317	144 (aa)	-	B9ZVT2
ENST00000492380	ANXA7-205	843	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000138279's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000138279's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000138279	ANXA7	96	81.210	ENSMUSG00000021814	Anxa7	100	89.535	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005178	integrin binding	21873635.	IBA	Function
GO:0005178	integrin binding	24007983.	IPI	Function
GO:0005509	calcium ion binding	-	IEA	Function
GO:0005515	protein binding	9268363.12445460.17699613.18256029.	IPI	Function
GO:0005544	calcium-dependent phospholipid binding	21873635.	IBA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	10672515.	IDA	Component
GO:0005635	nuclear envelope	-	IEA	Component
GO:0005789	endoplasmic reticulum membrane	10672515.	IDA	Component
GO:0005829	cytosol	-	IEA	Component
GO:0005886	plasma membrane	-	IEA	Component
GO:0006874	cellular calcium ion homeostasis	21873635.	IBA	Process
GO:0006914	autophagy	24007983.	IMP	Process
GO:0007599	hemostasis	-	IEA	Process
GO:0008283	cell proliferation	-	IEA	Process
GO:0008360	regulation of cell shape	-	IEA	Process
GO:0009651	response to salt stress	-	IEA	Process
GO:0009992	cellular water homeostasis	-	IEA	Process
GO:0010629	negative regulation of gene expression	24007983.	IMP	Process
GO:0014070	response to organic cyclic compound	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0030855	epithelial cell differentiation	21873635.	IBA	Process
GO:0030855	epithelial cell differentiation	21492153.	IEP	Process
GO:0035176	social behavior	21531385.	IEP	Process
GO:0042584	chromaffin granule membrane	21873635.	IBA	Component
GO:0042584	chromaffin granule membrane	9268363.	IDA	Component
GO:0042802	identical protein binding	21873635.	IBA	Function
GO:0048306	calcium-dependent protein binding	21873635.	IBA	Function
GO:0048306	calcium-dependent protein binding	12445460.	IPI	Function
GO:0051592	response to calcium ion	21873635.	IBA	Process
GO:0061025	membrane fusion	-	IEA	Process
GO:0062023	collagen-containing extracellular matrix	25037231.	HDA	Component
GO:0070062	extracellular exosome	19056867.19199708.20458337.23533145.	HDA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.