EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr2	215349752	3'UTR	novel		0.6
BLCA	chr2	215349147	Silent	rs771134346	L519L	0.28
BLCA	chr2	215312476	Intron	novel		0.34
BLCA	chr2	215312601	Silent	NA	L41L	0.35
BLCA	chr2	215326135	Silent	novel	L176L	0.15
BLCA	chr2	215332501	Missense_Mutation	novel	P270A	0.16
BLCA	chr2	215312376	Intron	novel		0.11
BLCA	chr2	215336068	Missense_Mutation	NA	E348K	0.43
BLCA	chr2	215346884	Silent	novel	V482V	0.13
BLCA	chr2	215312467	Intron	novel		0.37
BRCA	chr2	215332400	Frame_Shift_Ins	novel	*F237Ifs45**	0.14
BRCA	chr2	215312530	Missense_Mutation	NA	V18M	0.36
CESC	chr2	215346815	Silent	novel	G459G	0.39
CESC	chr2	215346843	Missense_Mutation	novel	H469Y	0.28
CESC	chr2	215332477	Missense_Mutation	rs150438200	A262T	0.57
CESC	chr2	215336053	Missense_Mutation	novel	A343T	0.17
CESC	chr2	215349601	Silent	rs762375034	C575C	0.1
CESC	chr2	215326132	Silent	novel	A175A	0.12
CESC	chr2	215349198	Missense_Mutation	novel	I536M	0.53
COAD	chr2	215332428	Silent	rs556427086	N245N	0.15
COAD	chr2	215349604	Silent	rs750485941	D576D	0.48
COAD	chr2	215326122	Missense_Mutation	rs766526084	R172H	0.21
COAD	chr2	215349732	3'UTR	novel		0.33
COAD	chr2	215326010	Missense_Mutation	NA	A135T	0.22
COAD	chr2	215349139	Frame_Shift_Del	NA	*E517Rfs11**	0.32
COAD	chr2	215326028	Nonsense_Mutation	rs774939270	R141*	0.27
COAD	chr2	215326891	Missense_Mutation	rs549649169	V201I	0.29
COAD	chr2	215349566	Missense_Mutation	rs149999349	G564S	0.33
COAD	chr2	215349169	Missense_Mutation	novel	W527R	0.13
COAD	chr2	215326835	Missense_Mutation	NA	T182R	0.35
COAD	chr2	215346823	Missense_Mutation	NA	A462V	0.16
COAD	chr2	215312549	Missense_Mutation	NA	L24P	0.33
COAD	chr2	215312476	Intron	novel		0.22
COAD	chr2	215338815	Nonsense_Mutation	rs200150457	R379*	0.27
COAD	chr2	215312380	Intron	novel		0.16
COAD	chr2	215338816	Missense_Mutation	rs199518893	R379Q	0.19
ESCA	chr2	215319728	Missense_Mutation	rs759249668	I96T	0.2
GBM	chr2	215326924	Missense_Mutation	novel	P212T	0.04
GBM	chr2	215334957	Missense_Mutation	novel	L321V	0.66
GBM	chr2	215349109	Missense_Mutation	novel	K507Q	0.07
HNSC	chr2	215312376	Intron	novel		0.23
HNSC	chr2	215326942	Missense_Mutation	novel	Q218K	0.23
HNSC	chr2	215349566	Missense_Mutation	novel	G564C	0.31
HNSC	chr2	215326122	Missense_Mutation	novel	R172L	0.23
HNSC	chr2	215318193	Missense_Mutation	NA	L61F	0.17
HNSC	chr2	215346837	Missense_Mutation	novel	L467V	0.18
HNSC	chr2	215312470	Intron	novel		0.22
KIRC	chr2	215326011	Missense_Mutation	novel	A135G	0.16
KIRC	chr2	215319688	Nonsense_Mutation	NA	E83*	0.31
KIRC	chr2	215346935	Silent	NA	I499I	0.37
KIRC	chr2	215333361	Frame_Shift_Del	novel	*G276Efs66**	0.09
KIRP	chr2	215349111	Missense_Mutation	novel	K507N	0.37
LGG	chr2	215344865	Silent	rs553792539	N438N	0.33
LIHC	chr2	215332496	Missense_Mutation	novel	V268A	0.34
LIHC	chr2	215312297	Intron	novel		0.56
LIHC	chr2	215333424	Missense_Mutation	novel	T297S	0.18
LUAD	chr2	215349157	Nonsense_Mutation	NA	E523*	0.47
LUAD	chr2	215332499	Missense_Mutation	NA	S269I	0.49
LUAD	chr2	215318193	Missense_Mutation	NA	L61F	0.12
LUAD	chr2	215344778	Splice_Site	novel	X410_splice	0.17
LUAD	chr2	215326978	Missense_Mutation	novel	V230I	0.09
LUAD	chr2	215332429	Missense_Mutation	rs776539487	A246T	0.49
LUAD	chr2	215349665	3'UTR	novel		0.17
LUAD	chr2	215312420	Intron	novel		0.2
LUSC	chr2	215336075	Missense_Mutation	novel	A350G	0.1
LUSC	chr2	215326880	Missense_Mutation	novel	Y197C	0.47
LUSC	chr2	215326135	Missense_Mutation	novel	L176F	0.13
LUSC	chr2	215338847	Silent	novel	K389K	0.2
LUSC	chr2	215326878	Missense_Mutation	NA	Q196H	0.27
LUSC	chr2	215326066	Silent	NA	V153V	0.11
LUSC	chr2	215312415	Intron	novel		0.15
LUSC	chr2	215344865	Silent	rs553792539	N438N	0.14
LUSC	chr2	215333458	Splice_Site	novel	X308_splice	0.13
LUSC	chr2	215336106	Silent	novel	G360G	0.27
LUSC	chr2	215333454	Missense_Mutation	novel	R307G	0.31
LUSC	chr2	215319715	Missense_Mutation	novel	D92N	0.11
OV	chr2	215338830	Missense_Mutation	NA	L384F	0.32
OV	chr2	215336061	Silent	NA	G345G	0.32
OV	chr2	215312579	Missense_Mutation	NA	S34F	0.54
OV	chr2	215326091	Missense_Mutation	novel	E162Q	0.31
OV	chr2	215326955	Missense_Mutation	novel	L222Q	0.22
OV	chr2	215349632	Missense_Mutation	novel	N586H	0.08
PAAD	chr2	215326028	Silent	novel	R141R	0.04
PAAD	chr2	215346830	Nonsense_Mutation	novel	Y464*	0.3
PRAD	chr2	215346765	Missense_Mutation	rs201074610	G443S	0.2
PRAD	chr2	215333438	Silent	rs372300174	A301A	0.35
PRAD	chr2	215325275	Missense_Mutation	novel	T109A	0.39
PRAD	chr2	215312582	Missense_Mutation	NA	G35E	0.18
PRAD	chr2	215346922	Missense_Mutation	novel	V495A	0.39
PRAD	chr2	215349545	Missense_Mutation	novel	A557T	0.12
READ	chr2	215344790	Silent	novel	S413S	0.07
READ	chr2	215312411	Intron	novel		0.29
SARC	chr2	215332491	Silent	novel	K266K	0.11
SKCM	chr2	215325328	Splice_Region	NA	I126I	0.35
SKCM	chr2	215332472	Missense_Mutation	rs750765780	P260L	0.43
SKCM	chr2	215336119	Missense_Mutation	rs779389808	L365F	0.39
SKCM	chr2	215349136	Missense_Mutation	NA	P516S	0.44
SKCM	chr2	215319685	Missense_Mutation	NA	P82S	0.24
SKCM	chr2	215332424	Missense_Mutation	NA	L244S	0.41
STAD	chr2	215312477	Intron	rs771601710		0.37
STAD	chr2	215344797	Nonsense_Mutation	rs556853914	R416*	0.43
STAD	chr2	215326891	Missense_Mutation	rs549649169	V201I	0.26
STAD	chr2	215332416	Silent	rs143393493	C241C	0.27
STAD	chr2	215349555	Missense_Mutation	rs372018177	A560V	0.3
STAD	chr2	215333451	Missense_Mutation	NA	A306T	0.05
STAD	chr2	215349695	3'UTR	novel		0.18
STAD	chr2	215349732	3'UTR	novel		0.33
STAD	chr2	215318217	Silent	NA	H69H	0.05
THCA	chr2	215319724	Nonsense_Mutation	novel	*L95Qfs6**	0.15
THCA	chr2	215349752	3'UTR	novel		0.32
UCEC	chr2	215326075	Silent	rs199801475	T156T	0.21
UCEC	chr2	215338816	Missense_Mutation	rs199518893	R379Q	0.3
UCEC	chr2	215326075	Silent	rs199801475	T156T	0.18
UCEC	chr2	215333438	Silent	rs372300174	A301A	0.38
UCEC	chr2	215336079	Missense_Mutation	novel	L351F	0.04
UCEC	chr2	215346863	Silent	rs779889028	S475S	0.43
UCEC	chr2	215336059	Nonsense_Mutation	novel	G345*	0.44
UCEC	chr2	215338803	Nonsense_Mutation	novel	E375*	0.31
UCEC	chr2	215333389	Missense_Mutation	novel	K285R	0.04
UCEC	chr2	215338816	Missense_Mutation	rs199518893	R379Q	0.19
UCEC	chr2	215336071	Missense_Mutation	NA	E349K	0.15
UCEC	chr2	215325274	Missense_Mutation	novel	K108N	0.06
UCEC	chr2	215349708	3'UTR	novel		0.26
UCEC	chr2	215346823	Missense_Mutation	NA	A462V	0.45
UCEC	chr2	215336079	Silent	NA	L351L	0.14
UCEC	chr2	215346883	Missense_Mutation	novel	V482A	0.44
UCEC	chr2	215349676	3'UTR	novel		0.27
UCEC	chr2	215333420	Silent	novel	T295T	0.41
UCEC	chr2	215349547	Silent	NA	A557A	0.32
UCEC	chr2	215344829	Missense_Mutation	novel	K426N	0.15
UCEC	chr2	215332416	Silent	rs143393493	C241C	0.44
UCEC	chr2	215346878	Silent	rs778454270	T480T	0.29
UCEC	chr2	215349732	3'UTR	novel		0.43
UCEC	chr2	215346912	Missense_Mutation	rs771474223	D492N	0.53
UCEC	chr2	215346928	Missense_Mutation	novel	G497E	0.4
UCEC	chr2	215338865	Silent	NA	V395V	0.31
UCEC	chr2	215336117	Missense_Mutation	novel	V364A	0.53
UCEC	chr2	215318163	Silent	novel	V51V	0.09
UCEC	chr2	215326024	Silent	rs775773173	H139H	0.41
UCEC	chr2	215346791	Silent	rs745674268	R451R	0.03
UCEC	chr2	215312501	Missense_Mutation	novel	L8S	0.3
UCEC	chr2	215318163	Silent	novel	V51V	0.24
UCEC	chr2	215312398	Intron	novel		0.29
UCEC	chr2	215326891	Missense_Mutation	rs549649169	V201I	0.37
UCEC	chr2	215318196	Silent	rs777126703	G62G	0.3
UCEC	chr2	215346857	Silent	novel	V473V	0.22
UCEC	chr2	215326932	Silent	novel	Q214Q	0.14
UCEC	chr2	215338895	Silent	novel	T405T	0.17
UCEC	chr2	215349630	Missense_Mutation	novel	T585M	0.4
UCEC	chr2	215318178	Silent	novel	G56G	0.41
UCEC	chr2	215333379	Missense_Mutation	NA	D282Y	0.12
UCEC	chr2	215349706	3'UTR	rs768314755		0.31
UCEC	chr2	215326898	Missense_Mutation	novel	Q203R	0.38

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
HNSC	DEL	0.2146	1.278e-25
KIRP	DEL	0.0313	5.174e-05
LUSC	DEL	0.2375	1.3904e-19
MESO	DEL	0.1264	0.014499
PAAD	AMP	0.0707	0.1091
PAAD	DEL	0.038	0.2014
THCA	DEL	0.024	0.040844

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.015	Kaplan-Meier Survival Analysis
ACC	0.00043	Kaplan-Meier Survival Analysis
BRCA	0.037	Kaplan-Meier Survival Analysis
KIRP	0.00022	Kaplan-Meier Survival Analysis
PAAD	0.026	Kaplan-Meier Survival Analysis
BLCA	0.0087	Kaplan-Meier Survival Analysis
LAML	0.0067	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
CHOL	0.049	Kaplan-Meier Survival Analysis
THCA	0.0088	Kaplan-Meier Survival Analysis
LUAD	0.0024	Kaplan-Meier Survival Analysis
UVM	0.00052	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000138363 (Gene tree)
Gene ID: 471
Gene Symbol: ATIC
Alias: PURH|AICARFT|IMPCHASE
Full Name: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 37,957 bases
Position: chr2:215,311,817-215,349,773
Accession: 794
RBP type: non-canonical RBP
Summary: This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria. [provided by RefSeq, Sep 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
10801888	Binding of PurH to a muscle-specific splicing enhancer functionally correlates with exon inclusion in vivo.	J Biol Chem	2000 Jul 7	Ryan KJ	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000478734	ATIC-212	486	-	-	- (aa)	-	-
ENST00000427397	ATIC-204	1046	-	ENSP00000394317	43 (aa)	-	F2Z3E8
ENST00000443953	ATIC-207	2187	-	ENSP00000406792	43 (aa)	-	F2Z3E8
ENST00000444305	ATIC-208	569	-	ENSP00000388675	84 (aa)	-	F8WEF0
ENST00000446622	ATIC-209	615	-	-	- (aa)	-	-
ENST00000479093	ATIC-213	772	-	-	- (aa)	-	-
ENST00000488712	ATIC-214	744	-	-	- (aa)	-	-
ENST00000467388	ATIC-211	714	-	-	- (aa)	-	-
ENST00000236959	ATIC-201	2213	XM_017004187	ENSP00000236959	592 (aa)	XP_016859676	P31939
ENST00000413174	ATIC-202	695	-	ENSP00000402393	170 (aa)	-	C9JLK0
ENST00000435675	ATIC-205	2275	XM_024452919	ENSP00000415935	591 (aa)	XP_024308687	P31939
ENST00000426233	ATIC-203	713	-	ENSP00000401936	231 (aa)	-	H7C1S2
ENST00000459796	ATIC-210	847	-	-	- (aa)	-	-
ENST00000442048	ATIC-206	442	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000138363's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00230	Purine metabolism	KEGG
hsa00670	One carbon pool by folate	KEGG
hsa01100	Metabolic pathways	KEGG
hsa01523	Antifolate resistance	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000138363	Body Height	9.5950000E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000138363's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000138363	ATIC	100	70.608	FBgn0039241	CG11089	100	70.608	Drosophila_melanogaster
ENSG00000138363	ATIC	100	91.176	ENSMUSG00000026192	Atic	100	91.047	Mus_musculus
ENSG00000138363	ATIC	99	61.630	YMR120C		99	61.630	Saccharomyces_cerevisiae
ENSG00000138363	ATIC	99	61.765	YLR028C		99	61.329	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003360	brainstem development	-	IEA	Process
GO:0003937	IMP cyclohydrolase activity	-	IEA	Function
GO:0004643	phosphoribosylaminoimidazolecarboxamide formyltransferase activity	-	IEA	Function
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0006139	nucleobase-containing compound metabolic process	8567683.	TAS	Process
GO:0006189	'de novo' IMP biosynthetic process	-	IEA	Process
GO:0009116	nucleoside metabolic process	-	IEA	Process
GO:0009168	purine ribonucleoside monophosphate biosynthetic process	-	TAS	Process
GO:0010035	response to inorganic substance	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0021549	cerebellum development	-	IEA	Process
GO:0021987	cerebral cortex development	-	IEA	Process
GO:0031100	animal organ regeneration	-	IEA	Process
GO:0042803	protein homodimerization activity	14756553.14966129.	IPI	Function
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0046452	dihydrofolate metabolic process	-	IEA	Process
GO:0046654	tetrahydrofolate biosynthetic process	-	IEA	Process
GO:0070062	extracellular exosome	19056867.20458337.23533145.	HDA	Component
GO:0098761	cellular response to interleukin-7	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.