EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr22153497523'UTRnovel0.6
BLCAchr2215349147Silentrs771134346L519L0.28
BLCAchr2215312476Intronnovel0.34
BLCAchr2215312601SilentNAL41L0.35
BLCAchr2215326135SilentnovelL176L0.15
BLCAchr2215332501Missense_MutationnovelP270A0.16
BLCAchr2215312376Intronnovel0.11
BLCAchr2215336068Missense_MutationNAE348K0.43
BLCAchr2215346884SilentnovelV482V0.13
BLCAchr2215312467Intronnovel0.37
BRCAchr2215332400Frame_Shift_InsnovelF237Ifs*450.14
BRCAchr2215312530Missense_MutationNAV18M0.36
CESCchr2215346815SilentnovelG459G0.39
CESCchr2215346843Missense_MutationnovelH469Y0.28
CESCchr2215332477Missense_Mutationrs150438200A262T0.57
CESCchr2215336053Missense_MutationnovelA343T0.17
CESCchr2215349601Silentrs762375034C575C0.1
CESCchr2215326132SilentnovelA175A0.12
CESCchr2215349198Missense_MutationnovelI536M0.53
COADchr2215332428Silentrs556427086N245N0.15
COADchr2215349604Silentrs750485941D576D0.48
COADchr2215326122Missense_Mutationrs766526084R172H0.21
COADchr22153497323'UTRnovel0.33
COADchr2215326010Missense_MutationNAA135T0.22
COADchr2215349139Frame_Shift_DelNAE517Rfs*110.32
COADchr2215326028Nonsense_Mutationrs774939270R141*0.27
COADchr2215326891Missense_Mutationrs549649169V201I0.29
COADchr2215349566Missense_Mutationrs149999349G564S0.33
COADchr2215349169Missense_MutationnovelW527R0.13
COADchr2215326835Missense_MutationNAT182R0.35
COADchr2215346823Missense_MutationNAA462V0.16
COADchr2215312549Missense_MutationNAL24P0.33
COADchr2215312476Intronnovel0.22
COADchr2215338815Nonsense_Mutationrs200150457R379*0.27
COADchr2215312380Intronnovel0.16
COADchr2215338816Missense_Mutationrs199518893R379Q0.19
ESCAchr2215319728Missense_Mutationrs759249668I96T0.2
GBMchr2215326924Missense_MutationnovelP212T0.04
GBMchr2215334957Missense_MutationnovelL321V0.66
GBMchr2215349109Missense_MutationnovelK507Q0.07
HNSCchr2215312376Intronnovel0.23
HNSCchr2215326942Missense_MutationnovelQ218K0.23
HNSCchr2215349566Missense_MutationnovelG564C0.31
HNSCchr2215326122Missense_MutationnovelR172L0.23
HNSCchr2215318193Missense_MutationNAL61F0.17
HNSCchr2215346837Missense_MutationnovelL467V0.18
HNSCchr2215312470Intronnovel0.22
KIRCchr2215326011Missense_MutationnovelA135G0.16
KIRCchr2215319688Nonsense_MutationNAE83*0.31
KIRCchr2215346935SilentNAI499I0.37
KIRCchr2215333361Frame_Shift_DelnovelG276Efs*660.09
KIRPchr2215349111Missense_MutationnovelK507N0.37
LGGchr2215344865Silentrs553792539N438N0.33
LIHCchr2215332496Missense_MutationnovelV268A0.34
LIHCchr2215312297Intronnovel0.56
LIHCchr2215333424Missense_MutationnovelT297S0.18
LUADchr2215349157Nonsense_MutationNAE523*0.47
LUADchr2215332499Missense_MutationNAS269I0.49
LUADchr2215318193Missense_MutationNAL61F0.12
LUADchr2215344778Splice_SitenovelX410_splice0.17
LUADchr2215326978Missense_MutationnovelV230I0.09
LUADchr2215332429Missense_Mutationrs776539487A246T0.49
LUADchr22153496653'UTRnovel0.17
LUADchr2215312420Intronnovel0.2
LUSCchr2215336075Missense_MutationnovelA350G0.1
LUSCchr2215326880Missense_MutationnovelY197C0.47
LUSCchr2215326135Missense_MutationnovelL176F0.13
LUSCchr2215338847SilentnovelK389K0.2
LUSCchr2215326878Missense_MutationNAQ196H0.27
LUSCchr2215326066SilentNAV153V0.11
LUSCchr2215312415Intronnovel0.15
LUSCchr2215344865Silentrs553792539N438N0.14
LUSCchr2215333458Splice_SitenovelX308_splice0.13
LUSCchr2215336106SilentnovelG360G0.27
LUSCchr2215333454Missense_MutationnovelR307G0.31
LUSCchr2215319715Missense_MutationnovelD92N0.11
OVchr2215338830Missense_MutationNAL384F0.32
OVchr2215336061SilentNAG345G0.32
OVchr2215312579Missense_MutationNAS34F0.54
OVchr2215326091Missense_MutationnovelE162Q0.31
OVchr2215326955Missense_MutationnovelL222Q0.22
OVchr2215349632Missense_MutationnovelN586H0.08
PAADchr2215326028SilentnovelR141R0.04
PAADchr2215346830Nonsense_MutationnovelY464*0.3
PRADchr2215346765Missense_Mutationrs201074610G443S0.2
PRADchr2215333438Silentrs372300174A301A0.35
PRADchr2215325275Missense_MutationnovelT109A0.39
PRADchr2215312582Missense_MutationNAG35E0.18
PRADchr2215346922Missense_MutationnovelV495A0.39
PRADchr2215349545Missense_MutationnovelA557T0.12
READchr2215344790SilentnovelS413S0.07
READchr2215312411Intronnovel0.29
SARCchr2215332491SilentnovelK266K0.11
SKCMchr2215325328Splice_RegionNAI126I0.35
SKCMchr2215332472Missense_Mutationrs750765780P260L0.43
SKCMchr2215336119Missense_Mutationrs779389808L365F0.39
SKCMchr2215349136Missense_MutationNAP516S0.44
SKCMchr2215319685Missense_MutationNAP82S0.24
SKCMchr2215332424Missense_MutationNAL244S0.41
STADchr2215312477Intronrs7716017100.37
STADchr2215344797Nonsense_Mutationrs556853914R416*0.43
STADchr2215326891Missense_Mutationrs549649169V201I0.26
STADchr2215332416Silentrs143393493C241C0.27
STADchr2215349555Missense_Mutationrs372018177A560V0.3
STADchr2215333451Missense_MutationNAA306T0.05
STADchr22153496953'UTRnovel0.18
STADchr22153497323'UTRnovel0.33
STADchr2215318217SilentNAH69H0.05
THCAchr2215319724Nonsense_MutationnovelL95Qfs*60.15
THCAchr22153497523'UTRnovel0.32
UCECchr2215326075Silentrs199801475T156T0.21
UCECchr2215338816Missense_Mutationrs199518893R379Q0.3
UCECchr2215326075Silentrs199801475T156T0.18
UCECchr2215333438Silentrs372300174A301A0.38
UCECchr2215336079Missense_MutationnovelL351F0.04
UCECchr2215346863Silentrs779889028S475S0.43
UCECchr2215336059Nonsense_MutationnovelG345*0.44
UCECchr2215338803Nonsense_MutationnovelE375*0.31
UCECchr2215333389Missense_MutationnovelK285R0.04
UCECchr2215338816Missense_Mutationrs199518893R379Q0.19
UCECchr2215336071Missense_MutationNAE349K0.15
UCECchr2215325274Missense_MutationnovelK108N0.06
UCECchr22153497083'UTRnovel0.26
UCECchr2215346823Missense_MutationNAA462V0.45
UCECchr2215336079SilentNAL351L0.14
UCECchr2215346883Missense_MutationnovelV482A0.44
UCECchr22153496763'UTRnovel0.27
UCECchr2215333420SilentnovelT295T0.41
UCECchr2215349547SilentNAA557A0.32
UCECchr2215344829Missense_MutationnovelK426N0.15
UCECchr2215332416Silentrs143393493C241C0.44
UCECchr2215346878Silentrs778454270T480T0.29
UCECchr22153497323'UTRnovel0.43
UCECchr2215346912Missense_Mutationrs771474223D492N0.53
UCECchr2215346928Missense_MutationnovelG497E0.4
UCECchr2215338865SilentNAV395V0.31
UCECchr2215336117Missense_MutationnovelV364A0.53
UCECchr2215318163SilentnovelV51V0.09
UCECchr2215326024Silentrs775773173H139H0.41
UCECchr2215346791Silentrs745674268R451R0.03
UCECchr2215312501Missense_MutationnovelL8S0.3
UCECchr2215318163SilentnovelV51V0.24
UCECchr2215312398Intronnovel0.29
UCECchr2215326891Missense_Mutationrs549649169V201I0.37
UCECchr2215318196Silentrs777126703G62G0.3
UCECchr2215346857SilentnovelV473V0.22
UCECchr2215326932SilentnovelQ214Q0.14
UCECchr2215338895SilentnovelT405T0.17
UCECchr2215349630Missense_MutationnovelT585M0.4
UCECchr2215318178SilentnovelG56G0.41
UCECchr2215333379Missense_MutationNAD282Y0.12
UCECchr22153497063'UTRrs7683147550.31
UCECchr2215326898Missense_MutationnovelQ203R0.38

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
HNSCDEL0.21461.278e-25
KIRPDEL0.03135.174e-05
LUSCDEL0.23751.3904e-19
MESODEL0.12640.014499
PAADAMP0.07070.1091
PAADDEL0.0380.2014
THCADEL0.0240.040844

Survival Analysis
CancerP-value Q-value
KIRC0.015

Kaplan-Meier Survival Analysis

ACC0.00043

Kaplan-Meier Survival Analysis

BRCA0.037

Kaplan-Meier Survival Analysis

KIRP0.00022

Kaplan-Meier Survival Analysis

PAAD0.026

Kaplan-Meier Survival Analysis

BLCA0.0087

Kaplan-Meier Survival Analysis

LAML0.0067

Kaplan-Meier Survival Analysis

LIHC0.0001

Kaplan-Meier Survival Analysis

CHOL0.049

Kaplan-Meier Survival Analysis

THCA0.0088

Kaplan-Meier Survival Analysis

LUAD0.0024

Kaplan-Meier Survival Analysis

UVM0.00052

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000138363 (Gene tree)
Gene ID
471
Gene Symbol
ATIC
Alias
PURH|AICARFT|IMPCHASE
Full Name
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
37,957 bases
Position
chr2:215,311,817-215,349,773
Accession
794
RBP type
non-canonical RBP
Summary
This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria. [provided by RefSeq, Sep 2009]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
10801888Binding of PurH to a muscle-specific splicing enhancer functionally correlates with exon inclusion in vivo.J Biol Chem2000 Jul 7Ryan KJ-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000478734ATIC-212486--- (aa)--
ENST00000427397ATIC-2041046-ENSP0000039431743 (aa)-F2Z3E8
ENST00000443953ATIC-2072187-ENSP0000040679243 (aa)-F2Z3E8
ENST00000444305ATIC-208569-ENSP0000038867584 (aa)-F8WEF0
ENST00000446622ATIC-209615--- (aa)--
ENST00000479093ATIC-213772--- (aa)--
ENST00000488712ATIC-214744--- (aa)--
ENST00000467388ATIC-211714--- (aa)--
ENST00000236959ATIC-2012213XM_017004187ENSP00000236959592 (aa)XP_016859676P31939
ENST00000413174ATIC-202695-ENSP00000402393170 (aa)-C9JLK0
ENST00000435675ATIC-2052275XM_024452919ENSP00000415935591 (aa)XP_024308687P31939
ENST00000426233ATIC-203713-ENSP00000401936231 (aa)-H7C1S2
ENST00000459796ATIC-210847--- (aa)--
ENST00000442048ATIC-206442--- (aa)--
Gene Model
Click here to download ENSG00000138363's gene model file
Pathways
Pathway IDPathway NameSource
hsa00230Purine metabolismKEGG
hsa00670One carbon pool by folateKEGG
hsa01100Metabolic pathwaysKEGG
hsa01523Antifolate resistanceKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000138363Body Height9.5950000E-005-
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000138363's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000138363ATIC10070.608FBgn0039241CG1108910070.608Drosophila_melanogaster
ENSG00000138363ATIC10091.176ENSMUSG00000026192Atic10091.047Mus_musculus
ENSG00000138363ATIC9961.630YMR120C9961.630Saccharomyces_cerevisiae
ENSG00000138363ATIC9961.765YLR028C9961.329Saccharomyces_cerevisiae
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003360brainstem development-IEAProcess
GO:0003937IMP cyclohydrolase activity-IEAFunction
GO:0004643phosphoribosylaminoimidazolecarboxamide formyltransferase activity-IEAFunction
GO:0005829cytosol-IDAComponent
GO:0005829cytosol-TASComponent
GO:0005886plasma membrane-IDAComponent
GO:0006139nucleobase-containing compound metabolic process8567683.TASProcess
GO:0006189'de novo' IMP biosynthetic process-IEAProcess
GO:0009116nucleoside metabolic process-IEAProcess
GO:0009168purine ribonucleoside monophosphate biosynthetic process-TASProcess
GO:0010035response to inorganic substance-IEAProcess
GO:0016020membrane19946888.HDAComponent
GO:0021549cerebellum development-IEAProcess
GO:0021987cerebral cortex development-IEAProcess
GO:0031100animal organ regeneration-IEAProcess
GO:0042803protein homodimerization activity14756553.14966129.IPIFunction
GO:0045296cadherin binding25468996.HDAFunction
GO:0046452dihydrofolate metabolic process-IEAProcess
GO:0046654tetrahydrofolate biosynthetic process-IEAProcess
GO:0070062extracellular exosome19056867.20458337.23533145.HDAComponent
GO:0098761cellular response to interleukin-7-IEAProcess
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