EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23236152	Evolutionarily conserved protein ERH controls CENP-E mRNA splicing and is required for the survival of KRAS mutant cancer cells.	Proc Natl Acad Sci U S A	2012 Dec 26	Weng MT	doi: 10.1073/pnas.1207673110
24928852	Chemogenetic evaluation of the mitotic kinesin CENP-E reveals a critical role in triple-negative breast cancer.	Mol Cancer Ther	2014 Aug	Kung PP	doi: 10.1158/1535-7163.MCT-14-0083-T

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr4	103145315	Missense_Mutation	novel	K1531R	0.42
ACC	chr4	103161409	Nonsense_Mutation	novel	E631*	0.11
ACC	chr4	103110954	Missense_Mutation	novel	G2533V	0.48
ACC	chr4	103145088	Missense_Mutation	novel	D1607Y	0.39
ACC	chr4	103159131	Missense_Mutation	novel	M827K	0.49
ACC	chr4	103181375	Nonsense_Mutation	novel	R349*	0.31
BLCA	chr4	103153166	Missense_Mutation	novel	E1040Q	0.4
BLCA	chr4	103195227	Missense_Mutation	novel	D122H	0.11
BLCA	chr4	103136338	Missense_Mutation	novel	E2109Q	0.16
BLCA	chr4	103145080	Silent	novel	L1609L	0.26
BLCA	chr4	103114552	Frame_Shift_Ins	novel	*E2481Dfs19**	0.11
BLCA	chr4	103161448	Missense_Mutation	novel	E618K	0.43
BLCA	chr4	103182774	Silent	NA	L317L	0.16
BLCA	chr4	103123068	Missense_Mutation	NA	E2316Q	0.51
BLCA	chr4	103159145	Missense_Mutation	NA	F822L	0.12
BLCA	chr4	103194442	Splice_Site	novel	X187_splice	0.22
BLCA	chr4	103139900	Silent	NA	L2031L	0.33
BLCA	chr4	103158812	Silent	rs758479628	L892L	0.31
BLCA	chr4	103146047	Missense_Mutation	novel	T1399A	0.51
BLCA	chr4	103159147	Missense_Mutation	novel	F822V	0.52
BLCA	chr4	103160634	Silent	novel	L759L	0.42
BLCA	chr4	103161215	Missense_Mutation	novel	D668N	0.28
BLCA	chr4	103153220	Missense_Mutation	novel	E1022K	0.82
BLCA	chr4	103148930	Nonsense_Mutation	NA	E1253*	0.31
BLCA	chr4	103146035	Missense_Mutation	rs377439303	V1403M	0.16
BLCA	chr4	103116653	Missense_Mutation	novel	E2456K	0.2
BLCA	chr4	103161164	Missense_Mutation	NA	D685N	0.27
BLCA	chr4	103161252	Splice_Site	NA	X656_splice	0.22
BLCA	chr4	103181369	Nonsense_Mutation	novel	E351*	0.2
BLCA	chr4	103145827	Splice_Site	NA	X1471_splice	0.22
BLCA	chr4	103148968	Missense_Mutation	novel	A1240V	0.25
BRCA	chr4	103140884	Missense_Mutation	NA	R1895I	0.32
BRCA	chr4	103159182	Missense_Mutation	rs779464384	S810L	0.37
BRCA	chr4	103145609	Silent	NA	L1496L	0.38
BRCA	chr4	103198325	5'UTR	novel		0.29
BRCA	chr4	103144594	Missense_Mutation	NA	Y1628H	0.26
BRCA	chr4	103163481	Missense_Mutation	NA	E574Q	0.27
BRCA	chr4	103139866	Nonsense_Mutation	NA	E2043*	0.45
BRCA	chr4	103145617	Missense_Mutation	novel	I1493T	0.08
BRCA	chr4	103141009	Missense_Mutation	novel	K1853N	0.08
BRCA	chr4	103194654	Missense_Mutation	NA	E170K	0.21
BRCA	chr4	103176955	Missense_Mutation	NA	N445T	0.18
BRCA	chr4	103158433	Missense_Mutation	rs201196207	R967Q	0.12
BRCA	chr4	103195182	Missense_Mutation	NA	E137K	0.14
BRCA	chr4	103174795	Missense_Mutation	novel	E530Q	0.13
BRCA	chr4	103138416	Missense_Mutation	NA	R2080G	0.18
BRCA	chr4	103139881	Missense_Mutation	NA	A2038P	0.23
BRCA	chr4	103141039	Silent	novel	Q1843Q	0.1
BRCA	chr4	103145226	Missense_Mutation	NA	D1561N	0.22
BRCA	chr4	103144529	Missense_Mutation	NA	L1649F	0.22
BRCA	chr4	103148966	Missense_Mutation	NA	H1241Y	0.2
BRCA	chr4	103153144	Missense_Mutation	NA	S1047Y	0.12
BRCA	chr4	103174856	Missense_Mutation	NA	N509K	0.21
BRCA	chr4	103145579	Missense_Mutation	NA	E1506Q	0.16
BRCA	chr4	103145984	Missense_Mutation	NA	E1420Q	0.15
BRCA	chr4	103140811	Splice_Region	novel		0.24
BRCA	chr4	103183273	Missense_Mutation	novel	E254V	0.08
BRCA	chr4	103149344	In_Frame_Ins	novel	Q1154delinsLIKE	0.05
BRCA	chr4	103158768	Frame_Shift_Ins	novel	*E907Gfs12**	0.06
BRCA	chr4	103158770	Nonsense_Mutation	novel	*E907Tfs5**	0.04
BRCA	chr4	103140073	Missense_Mutation	NA	E1974Q	0.11
BRCA	chr4	103146061	Missense_Mutation	novel	E1394V	0.1
BRCA	chr4	103140402	Nonsense_Mutation	novel	Q1923*	0.03
BRCA	chr4	103174858	Missense_Mutation	NA	N509D	0.13
BRCA	chr4	103143304	Nonsense_Mutation	NA	E1750*	0.42
BRCA	chr4	103145285	Missense_Mutation	novel	S1541N	0.1
CESC	chr4	103147607	Missense_Mutation	rs771685356	V1295M	0.22
CESC	chr4	103159222	Missense_Mutation	NA	E797K	0.12
CESC	chr4	103163494	Nonsense_Mutation	novel	Y569*	0.21
CESC	chr4	103146023	Nonsense_Mutation	NA	E1407*	0.26
CESC	chr4	103139860	Frame_Shift_Del	novel	*R2045Efs23**	0.08
CESC	chr4	103114498	Missense_Mutation	NA	L2499F	0.14
CESC	chr4	103161445	Missense_Mutation	NA	D619N	0.22
CESC	chr4	103174811	Missense_Mutation	novel	M524I	0.1
CESC	chr4	103180465	Missense_Mutation	novel	S363Y	0.2
CESC	chr4	103140058	Frame_Shift_Ins	novel	*E1979Rfs6**	0.25
CESC	chr4	103148907	Missense_Mutation	novel	E1260D	0.23
CESC	chr4	103145139	Missense_Mutation	novel	K1590E	0.16
CESC	chr4	103144375	Missense_Mutation	novel	E1701Q	0.22
CESC	chr4	103198310	Missense_Mutation	novel	E4K	0.31
CESC	chr4	103182790	Missense_Mutation	novel	S312F	0.06
CESC	chr4	103140312	Missense_Mutation	novel	Q1953E	0.3
CESC	chr4	103144616	Missense_Mutation	novel	M1620I	0.46
CHOL	chr4	103110984	Missense_Mutation	novel	P2523H	0.07
CHOL	chr4	103163176	Silent	novel	Q601Q	0.16
COAD	chr4	103108812	Missense_Mutation	NA	L2668I	0.35
COAD	chr4	103136356	Missense_Mutation	NA	L2103F	0.37
COAD	chr4	103159035	Missense_Mutation	NA	S859L	0.24
COAD	chr4	103151291	Silent	novel	A1108A	0.29
COAD	chr4	103111010	Splice_Region	novel	V2514V	0.28
COAD	chr4	103148886	Missense_Mutation	novel	N1267K	0.26
COAD	chr4	103110884	Missense_Mutation	NA	I2556M	0.38
COAD	chr4	103116590	Nonsense_Mutation	novel	E2477*	0.06
COAD	chr4	103176963	Missense_Mutation	novel	I442M	0.35
COAD	chr4	103132782	Missense_Mutation	rs544326830	R2279C	0.29
COAD	chr4	103139993	Silent	NA	E2000E	0.19
COAD	chr4	103176957	Silent	novel	T444T	0.21
COAD	chr4	103108928	Missense_Mutation	rs141321114	R2629Q	0.36
COAD	chr4	103138416	Frame_Shift_Del	NA	*R2080Gfs3**	0.3
COAD	chr4	103148984	Nonsense_Mutation	NA	E1235*	0.34
COAD	chr4	103153242	Silent	rs779763209	G1014G	0.33
COAD	chr4	103108939	Silent	rs141957526	Q2625Q	0.27
COAD	chr4	103140329	Missense_Mutation	NA	I1947N	0.26
COAD	chr4	103147584	Missense_Mutation	novel	Q1302H	0.34
COAD	chr4	103161375	Missense_Mutation	NA	A642V	0.24
COAD	chr4	103106296	Missense_Mutation	novel	E2678K	0.04
COAD	chr4	103140380	Missense_Mutation	rs115310306	R1930H	0.36
COAD	chr4	103159200	Missense_Mutation	NA	D804G	0.34
COAD	chr4	103144456	Missense_Mutation	novel	L1674V	0.17
COAD	chr4	103153238	Missense_Mutation	NA	D1016H	0.4
COAD	chr4	103153251	Splice_Site	rs111987461	X1012_splice	0.4
COAD	chr4	103140887	Missense_Mutation	NA	L1894R	0.18
COAD	chr4	103108821	Missense_Mutation	rs758197733	S2665G	0.11
COAD	chr4	103148967	Silent	rs771019272	A1240A	0.37
COAD	chr4	103180470	Splice_Site	novel	X362_splice	0.16
COAD	chr4	103194654	Missense_Mutation	NA	E170K	0.27
COAD	chr4	103146013	Missense_Mutation	NA	K1410I	0.58
COAD	chr4	103147644	Splice_Region	NA	I1282I	0.31
COAD	chr4	103108862	Missense_Mutation	NA	S2651Y	0.13
COAD	chr4	103132746	Frame_Shift_Ins	novel	*K2291Hfs13**	0.04
COAD	chr4	103136302	Frame_Shift_Ins	novel	*S2121Efs18**	0.05
COAD	chr4	103159235	Frame_Shift_Ins	novel	*Q792Hfs16**	0.04
ESCA	chr4	103194393	Missense_Mutation	novel	S203F	0.72
ESCA	chr4	103195134	Missense_Mutation	novel	I153V	0.67
ESCA	chr4	103176006	Missense_Mutation	novel	T478R	0.38
ESCA	chr4	103144377	Missense_Mutation	novel	V1700A	0.39
ESCA	chr4	103145313	Missense_Mutation	novel	E1532K	0.33
GBM	chr4	103144462	Nonsense_Mutation	novel	Q1672*	0.06
GBM	chr4	103122984	Missense_Mutation	NA	K2344E	0.3
GBM	chr4	103158652	Missense_Mutation	NA	D946N	0.41
GBM	chr4	103144482	Missense_Mutation	rs781248304	T1665M	0.17
GBM	chr4	103159088	Silent	rs550951923	E841E	0.12
GBM	chr4	103108888	Silent	NA	S2642S	0.06
GBM	chr4	103122990	Silent	novel	L2342L	0.08
GBM	chr4	103158787	Missense_Mutation	novel	S901A	0.33
GBM	chr4	103161115	Missense_Mutation	novel	T701I	0.37
GBM	chr4	103147403	Missense_Mutation	NA	V1363F	0.34
HNSC	chr4	103159124	Missense_Mutation	novel	F829L	0.28
HNSC	chr4	103133776	Silent	novel	Q2213Q	0.72
HNSC	chr4	103120156	Missense_Mutation	novel	V2441I	0.35
HNSC	chr4	103161204	Missense_Mutation	novel	L671F	0.12
HNSC	chr4	103149134	Missense_Mutation	novel	R1224T	0.34
HNSC	chr4	103141070	Missense_Mutation	novel	I1833T	0.18
HNSC	chr4	103194242	Missense_Mutation	novel	K227T	0.19
HNSC	chr4	103147577	Missense_Mutation	rs750498079	M1305V	0.53
HNSC	chr4	103145296	Missense_Mutation	novel	I1537M	0.45
HNSC	chr4	103136253	Missense_Mutation	NA	R2137K	0.09
HNSC	chr4	103158824	Silent	novel	E888E	0.24
HNSC	chr4	103108914	Missense_Mutation	novel	P2634S	0.11
HNSC	chr4	103133769	Nonsense_Mutation	novel	Q2216*	0.24
HNSC	chr4	103149272	Missense_Mutation	novel	E1178V	0.51
HNSC	chr4	103140865	Silent	novel	L1901L	0.04
HNSC	chr4	103106129	3'UTR	novel		0.31
HNSC	chr4	103139796	Missense_Mutation	novel	I2066K	0.48
HNSC	chr4	103158406	Missense_Mutation	novel	H976L	0.7
KICH	chr4	103180352	Missense_Mutation	novel	L401V	0.16
KIRC	chr4	103141095	Missense_Mutation	NA	L1825I	0.06
KIRC	chr4	103133783	Missense_Mutation	NA	K2211R	0.22
KIRC	chr4	103159079	Missense_Mutation	NA	N844K	0.09
KIRC	chr4	103160659	Missense_Mutation	novel	S751F	0.25
KIRC	chr4	103182892	Splice_Site	novel	X278_splice	0.23
KIRP	chr4	103195139	Missense_Mutation	novel	P151L	0.14
KIRP	chr4	103143340	Missense_Mutation	NA	D1738H	0.21
KIRP	chr4	103195973	Missense_Mutation	rs758681737	H102Y	0.18
KIRP	chr4	103195962	Silent	NA	V105V	0.2
KIRP	chr4	103149170	Missense_Mutation	NA	F1212Y	0.24
KIRP	chr4	103120314	Frame_Shift_Del	novel	*N2388Ifs18**	0.32
KIRP	chr4	103160648	Missense_Mutation	NA	E755K	0.44
KIRP	chr4	103144598	Frame_Shift_Del	novel	*E1627Nfs7**	0.15
LAML	chr4	103161115	Missense_Mutation	novel	T701I	0.07
LAML	chr4	103153203	Missense_Mutation	rs755920648	Q1027H	0.17
LGG	chr4	103145228	Missense_Mutation	novel	K1560R	0.21
LGG	chr4	103108862	Missense_Mutation	novel	S2651C	0.1
LGG	chr4	103132801	Frame_Shift_Ins	novel	*L2272Ffs10**	0.31
LGG	chr4	103159191	Missense_Mutation	novel	T807I	0.43
LGG	chr4	103141750	Missense_Mutation	novel	K1821N	0.06
LIHC	chr4	103198336	5'UTR	novel		0.49
LIHC	chr4	103158382	Missense_Mutation	NA	K984I	0.85
LIHC	chr4	103139791	Missense_Mutation	NA	R2068G	0.68
LIHC	chr4	103132721	Missense_Mutation	NA	V2299E	0.39
LIHC	chr4	103145121	Nonsense_Mutation	novel	K1596*	0.16
LIHC	chr4	103145298	Missense_Mutation	NA	I1537V	0.28
LIHC	chr4	103144556	Silent	NA	Q1640Q	0.57
LIHC	chr4	103198349	5'UTR	novel		0.32
LIHC	chr4	103140035	Missense_Mutation	novel	K1986N	0.37
LIHC	chr4	103144461	Missense_Mutation	novel	Q1672R	0.41
LIHC	chr4	103163487	Missense_Mutation	NA	D572Y	0.23
LUAD	chr4	103149404	Missense_Mutation	NA	Q1134L	0.25
LUAD	chr4	103161343	Nonsense_Mutation	novel	E653*	0.16
LUAD	chr4	103146092	Missense_Mutation	NA	S1384G	0.28
LUAD	chr4	103106268	Missense_Mutation	novel	W2687L	0.33
LUAD	chr4	103140038	Silent	novel	V1985V	0.19
LUAD	chr4	103180329	Silent	novel	T408T	0.2
LUAD	chr4	103140296	Missense_Mutation	novel	Q1958P	0.1
LUAD	chr4	103120190	Missense_Mutation	NA	N2429K	0.21
LUAD	chr4	103195213	Silent	novel	L126L	0.24
LUAD	chr4	103195111	Splice_Region	novel		0.09
LUAD	chr4	103153095	Missense_Mutation	rs775291777	I1063M	0.1
LUAD	chr4	103141009	Silent	novel	K1853K	0.1
LUAD	chr4	103139847	Missense_Mutation	NA	E2049G	0.33
LUAD	chr4	103138377	Missense_Mutation	novel	L2093M	0.14
LUAD	chr4	103108838	Missense_Mutation	novel	R2659L	0.31
LUAD	chr4	103160748	Missense_Mutation	NA	K721N	0.13
LUAD	chr4	103149404	Missense_Mutation	NA	Q1134L	0.21
LUAD	chr4	103110872	Missense_Mutation	novel	K2560N	0.09
LUAD	chr4	103145110	Missense_Mutation	novel	Q1599H	0.6
LUAD	chr4	103163203	Silent	NA	K592K	0.22
LUAD	chr4	103144375	Nonsense_Mutation	novel	E1701*	0.23
LUAD	chr4	103158326	Missense_Mutation	novel	E1003Q	0.29
LUAD	chr4	103182789	Silent	novel	S312S	0.16
LUAD	chr4	103116657	Silent	novel	K2454K	0.1
LUAD	chr4	103116659	Nonsense_Mutation	novel	K2454*	0.11
LUAD	chr4	103106235	Missense_Mutation	novel	C2698F	0.19
LUAD	chr4	103149396	Nonsense_Mutation	novel	Q1137*	0.35
LUAD	chr4	103106191	3'UTR	novel		0.08
LUAD	chr4	103146044	Missense_Mutation	NA	T1400A	0.15
LUAD	chr4	103145972	Missense_Mutation	NA	L1424V	0.1
LUAD	chr4	103161434	Missense_Mutation	novel	Q622H	0.19
LUAD	chr4	103145668	Missense_Mutation	novel	E1476V	0.17
LUAD	chr4	103180438	Missense_Mutation	NA	E372V	0.13
LUAD	chr4	103195206	Missense_Mutation	NA	V129L	0.42
LUSC	chr4	103122917	Missense_Mutation	novel	N2366I	0.36
LUSC	chr4	103145111	Missense_Mutation	novel	Q1599L	0.24
LUSC	chr4	103145888	Missense_Mutation	novel	E1452Q	0.34
LUSC	chr4	103122891	Missense_Mutation	novel	A2375T	0.09
LUSC	chr4	103143340	Missense_Mutation	NA	D1738H	0.34
LUSC	chr4	103141832	Missense_Mutation	NA	R1794T	0.25
LUSC	chr4	103110917	Silent	NA	L2545L	0.16
LUSC	chr4	103158299	Splice_Site	novel	X1011_splice	0.39
LUSC	chr4	103108902	Missense_Mutation	NA	E2638Q	0.1
LUSC	chr4	103147422	Silent	NA	T1356T	0.12
LUSC	chr4	103123054	Missense_Mutation	NA	R2320S	0.36
LUSC	chr4	103158825	Missense_Mutation	novel	E888V	0.25
LUSC	chr4	103161349	Missense_Mutation	NA	L651M	0.12
LUSC	chr4	103141826	Missense_Mutation	novel	I1796T	0.28
LUSC	chr4	103133697	Nonsense_Mutation	NA	E2240*	0.26
LUSC	chr4	103145913	Silent	novel	E1443E	0.19
LUSC	chr4	103151275	Missense_Mutation	novel	E1114Q	0.14
LUSC	chr4	103160759	Missense_Mutation	novel	L718M	0.62
LUSC	chr4	103180357	Missense_Mutation	novel	R399L	0.09
LUSC	chr4	103133803	Missense_Mutation	novel	K2204N	0.14
LUSC	chr4	103180421	Nonsense_Mutation	novel	Q378*	0.16
LUSC	chr4	103163134	Splice_Region	novel		0.26
LUSC	chr4	103174796	Missense_Mutation	NA	K529N	0.84
LUSC	chr4	103116672	Silent	novel	G2449G	0.25
LUSC	chr4	103153226	Missense_Mutation	novel	D1020H	0.4
LUSC	chr4	103160655	Silent	novel	L752L	0.13
LUSC	chr4	103146023	Nonsense_Mutation	NA	E1407*	0.2
LUSC	chr4	103140852	Missense_Mutation	rs767613874	D1906Y	0.13
LUSC	chr4	103160781	Splice_Site	novel	X711_splice	0.45
LUSC	chr4	103140001	Missense_Mutation	novel	E1998Q	0.44
LUSC	chr4	103145127	Missense_Mutation	NA	E1594K	0.2
LUSC	chr4	103182812	Missense_Mutation	novel	I305V	0.04
LUSC	chr4	103116612	Silent	novel	L2469L	0.19
LUSC	chr4	103120297	Missense_Mutation	novel	K2394E	0.1
LUSC	chr4	103176993	Missense_Mutation	novel	K432N	0.32
LUSC	chr4	103144345	Missense_Mutation	novel	E1711K	0.45
OV	chr4	103116603	Missense_Mutation	NA	M2472I	0.2
OV	chr4	103159224	Frame_Shift_Ins	novel	*E796Gfs13**	0.22
OV	chr4	103145596	Frame_Shift_Del	novel	*N1499Ifs15**	0.07
OV	chr4	103136160	Missense_Mutation	novel	R2168I	0.11
OV	chr4	103108880	Missense_Mutation	NA	F2645S	0.51
OV	chr4	103196765	Missense_Mutation	novel	N48H	0.07
OV	chr4	103133845	Silent	NA	S2190S	0.26
OV	chr4	103114500	Silent	rs202097843	L2499L	0.33
OV	chr4	103182857	Nonsense_Mutation	NA	R290*	0.7
PAAD	chr4	103120327	Nonsense_Mutation	rs267599968	R2384*	0.16
PAAD	chr4	103153243	Missense_Mutation	novel	G1014D	0.13
PRAD	chr4	103144481	Silent	NA	T1665T	0.19
PRAD	chr4	103109065	Missense_Mutation	NA	E2583D	0.07
PRAD	chr4	103147491	Silent	rs745496238	L1333L	0.56
PRAD	chr4	103120238	Silent	NA	V2413V	0.19
PRAD	chr4	103122870	Splice_Site	novel	X2381_splice	0.13
PRAD	chr4	103108913	Missense_Mutation	novel	P2634H	0.38
READ	chr4	103108929	Missense_Mutation	rs187303852	R2629W	0.39
READ	chr4	103145844	Silent	NA	K1466K	0.34
READ	chr4	103110949	Missense_Mutation	rs756483643	G2535S	0.31
READ	chr4	103108940	Missense_Mutation	rs772361306	Q2625R	0.28
READ	chr4	103147454	Missense_Mutation	NA	S1346A	0.2
READ	chr4	103108839	Missense_Mutation	rs774765853	R2659C	0.42
READ	chr4	103149204	Nonsense_Mutation	novel	E1201*	0.37
READ	chr4	103149270	Missense_Mutation	novel	T1179A	0.36
READ	chr4	103151305	Nonsense_Mutation	NA	E1104*	0.12
READ	chr4	103158875	Missense_Mutation	NA	K871N	0.45
READ	chr4	103180403	Missense_Mutation	novel	D384Y	0.38
READ	chr4	103123073	Missense_Mutation	novel	S2314L	0.04
READ	chr4	103109000	Missense_Mutation	novel	S2605Y	0.09
READ	chr4	103110884	Missense_Mutation	NA	I2556M	0.32
SARC	chr4	103159234	Missense_Mutation	novel	G793R	0.17
SARC	chr4	103149396	Missense_Mutation	novel	Q1137E	0.33
SARC	chr4	103139903	Silent	novel	S2030S	0.29
SARC	chr4	103140840	Missense_Mutation	novel	E1910K	0.48
SARC	chr4	103153216	Missense_Mutation	novel	A1023D	0.1
SARC	chr4	103163521	Silent	novel	K560K	0.21
SKCM	chr4	103148865	Silent	novel	S1274S	0.4
SKCM	chr4	103149200	Missense_Mutation	NA	R1202K	0.22
SKCM	chr4	103114484	Missense_Mutation	novel	R2504K	0.19
SKCM	chr4	103158765	Missense_Mutation	NA	R908K	0.34
SKCM	chr4	103158778	Missense_Mutation	NA	Q904K	0.43
SKCM	chr4	103147446	Silent	novel	T1348T	0.09
SKCM	chr4	103147447	Missense_Mutation	novel	T1348I	0.09
SKCM	chr4	103141860	Missense_Mutation	NA	E1785K	0.41
SKCM	chr4	103159008	Splice_Site	NA	X867_splice	0.29
SKCM	chr4	103138438	Missense_Mutation	novel	N2072K	0.25
SKCM	chr4	103196175	Nonsense_Mutation	novel	Q76*	0.36
SKCM	chr4	103122908	Missense_Mutation	rs780652836	P2369L	0.19
SKCM	chr4	103136229	Missense_Mutation	NA	P2145H	0.28
SKCM	chr4	103140818	Missense_Mutation	NA	A1917V	0.38
SKCM	chr4	103160671	Missense_Mutation	NA	S747L	0.13
SKCM	chr4	103108805	Missense_Mutation	NA	P2670L	0.5
SKCM	chr4	103158631	Missense_Mutation	NA	H953Y	0.43
SKCM	chr4	103122933	Missense_Mutation	NA	P2361S	0.58
SKCM	chr4	103140348	Missense_Mutation	novel	D1941N	0.26
SKCM	chr4	103132864	Silent	novel	F2251F	0.4
SKCM	chr4	103140889	Missense_Mutation	novel	N1893K	0.95
SKCM	chr4	103158880	Missense_Mutation	novel	Y870H	0.23
SKCM	chr4	103174873	Missense_Mutation	NA	R504C	0.5
SKCM	chr4	103132895	Missense_Mutation	NA	E2241G	0.32
SKCM	chr4	103148866	Missense_Mutation	rs779588591	S1274F	0.25
SKCM	chr4	103108839	Missense_Mutation	rs774765853	R2659C	0.79
SKCM	chr4	103108817	Missense_Mutation	novel	L2666S	0.53
SKCM	chr4	103195230	Missense_Mutation	novel	P121S	0.18
SKCM	chr4	103159056	Missense_Mutation	NA	K852I	0.14
SKCM	chr4	103140032	Frame_Shift_Del	novel	*D1988Mfs4**	0.29
SKCM	chr4	103146036	Silent	NA	I1402I	0.27
SKCM	chr4	103145094	Missense_Mutation	novel	E1605K	0.36
SKCM	chr4	103145136	Missense_Mutation	NA	E1591K	0.31
SKCM	chr4	103144375	Missense_Mutation	rs772375325	E1701K	0.24
SKCM	chr4	103123064	Missense_Mutation	novel	F2317C	0.16
SKCM	chr4	103159153	Missense_Mutation	NA	Q820E	0.33
SKCM	chr4	103108839	Missense_Mutation	rs774765853	R2659C	0.24
SKCM	chr4	103148845	Missense_Mutation	novel	E1281A	1
SKCM	chr4	103136171	Missense_Mutation	NA	M2164I	0.43
SKCM	chr4	103145986	Missense_Mutation	rs756176401	I1419T	0.12
SKCM	chr4	103160682	Silent	NA	V743V	0.16
SKCM	chr4	103136291	Silent	rs777063765	L2124L	0.17
SKCM	chr4	103141853	Missense_Mutation	NA	Q1787R	0.55
SKCM	chr4	103145968	Missense_Mutation	rs113334734	G1425E	0.24
SKCM	chr4	103145572	Missense_Mutation	NA	S1508L	0.17
SKCM	chr4	103158873	Missense_Mutation	NA	T872I	0.21
SKCM	chr4	103163530	Silent	rs575353274	S557S	0.44
SKCM	chr4	103176949	Missense_Mutation	novel	T447I	0.53
SKCM	chr4	103106215	3'UTR	NA		0.32
SKCM	chr4	103158673	Missense_Mutation	novel	E939K	0.24
SKCM	chr4	103163191	Missense_Mutation	NA	E596D	0.44
SKCM	chr4	103144480	Missense_Mutation	NA	E1666K	0.4
SKCM	chr4	103145656	Missense_Mutation	novel	K1480R	0.41
SKCM	chr4	103149168	Missense_Mutation	novel	E1213K	0.33
SKCM	chr4	103163531	Missense_Mutation	novel	S557L	0.4
SKCM	chr4	103158862	Nonsense_Mutation	NA	Q876*	0.3
SKCM	chr4	103145835	Silent	NA	V1469V	0.42
STAD	chr4	103158773	Silent	novel	T905T	0.07
STAD	chr4	103144567	Missense_Mutation	NA	N1637D	0.3
STAD	chr4	103108879	Frame_Shift_Del	novel	*F2645Lfs22**	0.33
STAD	chr4	103116665	Missense_Mutation	novel	P2452S	0.29
STAD	chr4	103182840	Silent	NA	S295S	0.26
STAD	chr4	103159035	Missense_Mutation	NA	S859L	0.27
STAD	chr4	103160746	Missense_Mutation	NA	I722S	0.33
STAD	chr4	103176900	Splice_Region	NA	E463E	0.52
STAD	chr4	103195209	Missense_Mutation	NA	R128C	0.3
STAD	chr4	103196250	Missense_Mutation	NA	R51C	0.29
STAD	chr4	103148898	Frame_Shift_Ins	novel	*Q1264Nfs7**	0.07
STAD	chr4	103138429	Silent	NA	V2075V	0.04
STAD	chr4	103159183	Missense_Mutation	NA	S810P	0.08
STAD	chr4	103180442	Missense_Mutation	NA	M371V	0.08
STAD	chr4	103185820	Silent	NA	T245T	0.09
STAD	chr4	103133752	Silent	novel	V2221V	0.17
STAD	chr4	103145848	Missense_Mutation	NA	I1465T	0.24
STAD	chr4	103144531	Missense_Mutation	novel	L1649M	0.27
STAD	chr4	103180365	Silent	novel	N396N	0.07
STAD	chr4	103144575	Missense_Mutation	NA	T1634I	0.26
STAD	chr4	103195226	Missense_Mutation	novel	D122A	0.16
STAD	chr4	103145286	Missense_Mutation	NA	S1541G	0.28
STAD	chr4	103145901	Silent	rs114566933	L1447L	0.28
STAD	chr4	103108888	Silent	NA	S2642S	0.13
STAD	chr4	103158860	Missense_Mutation	novel	Q876H	0.1
STAD	chr4	103183221	Silent	NA	K271K	0.22
STAD	chr4	103146010	Missense_Mutation	NA	P1411H	0.25
STAD	chr4	103145253	Nonsense_Mutation	novel	Q1552*	0.32
THCA	chr4	103149280	Frame_Shift_Del	novel	*E1175Dfs21**	0.07
UCEC	chr4	103158427	Missense_Mutation	rs754690682	A969V	0.27
UCEC	chr4	103160748	Silent	NA	K721K	0.31
UCEC	chr4	103108839	Missense_Mutation	rs774765853	R2659C	0.3
UCEC	chr4	103139871	Missense_Mutation	NA	R2041I	0.33
UCEC	chr4	103147635	Silent	NA	L1285L	0.25
UCEC	chr4	103122953	Missense_Mutation	novel	A2354V	0.41
UCEC	chr4	103133708	Missense_Mutation	novel	D2236G	0.38
UCEC	chr4	103149350	Missense_Mutation	novel	E1152G	0.43
UCEC	chr4	103159182	Missense_Mutation	rs779464384	S810L	0.37
UCEC	chr4	103158433	Missense_Mutation	rs201196207	R967Q	0.29
UCEC	chr4	103132818	Nonsense_Mutation	rs760219934	E2267*	0.12
UCEC	chr4	103136353	Missense_Mutation	NA	L2104V	0.38
UCEC	chr4	103140381	Missense_Mutation	rs780081164	R1930C	0.31
UCEC	chr4	103158628	Missense_Mutation	rs201814347	D954N	0.29
UCEC	chr4	103194654	Nonsense_Mutation	NA	E170*	0.32
UCEC	chr4	103120230	Missense_Mutation	novel	D2416G	0.52
UCEC	chr4	103158634	Missense_Mutation	novel	I952V	0.36
UCEC	chr4	103114488	Missense_Mutation	NA	L2503I	0.42
UCEC	chr4	103136184	Missense_Mutation	novel	Q2160L	0.03
UCEC	chr4	103139870	Silent	NA	R2041R	0.23
UCEC	chr4	103183241	Missense_Mutation	novel	L265V	0.4
UCEC	chr4	103148886	Silent	novel	N1267N	0.48
UCEC	chr4	103159182	Missense_Mutation	rs779464384	S810L	0.18
UCEC	chr4	103109040	Missense_Mutation	novel	L2592F	0.2
UCEC	chr4	103148915	Missense_Mutation	rs200458836	V1258I	0.37
UCEC	chr4	103159121	Missense_Mutation	novel	E830D	0.58
UCEC	chr4	103147453	Missense_Mutation	novel	S1346Y	0.22
UCEC	chr4	103120289	Silent	NA	S2396S	0.12
UCEC	chr4	103132711	Missense_Mutation	NA	F2302L	0.18
UCEC	chr4	103140381	Missense_Mutation	rs780081164	R1930C	0.27
UCEC	chr4	103158853	Missense_Mutation	NA	T879A	0.23
UCEC	chr4	103196167	Silent	novel	Y78Y	0.05
UCEC	chr4	103108889	Missense_Mutation	NA	S2642Y	0.19
UCEC	chr4	103140254	Splice_Site	NA	X1971_splice	0.17
UCEC	chr4	103145528	Missense_Mutation	novel	N1523D	0.35
UCEC	chr4	103132806	Missense_Mutation	NA	F2271I	0.39
UCEC	chr4	103114528	Nonsense_Mutation	novel	*V2489_E2490insFSNGTQT**	0.07
UCEC	chr4	103114530	Missense_Mutation	novel	V2489L	0.01
UCEC	chr4	103141062	Missense_Mutation	NA	K1836E	0.27
UCEC	chr4	103158850	Missense_Mutation	rs773744712	R880C	0.21
UCEC	chr4	103158629	Silent	novel	H953H	0.19
UCEC	chr4	103174838	Missense_Mutation	novel	E515D	0.22
UCEC	chr4	103159145	Missense_Mutation	novel	F822L	0.48
UCEC	chr4	103132879	Missense_Mutation	NA	F2246L	0.41
UCEC	chr4	103145882	Missense_Mutation	NA	L1454I	0.51
UCEC	chr4	103158781	Missense_Mutation	NA	L903M	0.47
UCEC	chr4	103159035	Missense_Mutation	NA	S859L	0.5
UCEC	chr4	103163153	Missense_Mutation	novel	D609G	0.1
UCEC	chr4	103141100	Missense_Mutation	NA	Q1823R	0.48
UCEC	chr4	103136175	Missense_Mutation	rs759827260	S2163F	0.41
UCEC	chr4	103141766	Missense_Mutation	novel	A1816V	0.09
UCEC	chr4	103132711	Missense_Mutation	NA	F2302L	0.47
UCEC	chr4	103136299	Missense_Mutation	novel	L2122I	0.29
UCEC	chr4	103133719	Missense_Mutation	novel	N2232K	0.21
UCEC	chr4	103139818	Missense_Mutation	novel	I2059V	0.3
UCEC	chr4	103161235	Missense_Mutation	novel	T661I	0.33
UCEC	chr4	103108867	Silent	novel	S2649S	0.27
UCEC	chr4	103147453	Missense_Mutation	novel	S1346F	0.34
UCEC	chr4	103147599	Silent	novel	E1297E	0.04
UCEC	chr4	103174741	Missense_Mutation	novel	Q548K	0.39
UCEC	chr4	103194616	Missense_Mutation	novel	I182M	0.34
UCEC	chr4	103140299	Missense_Mutation	novel	I1957T	0.17
UCEC	chr4	103145323	Missense_Mutation	novel	I1528M	0.39
UCEC	chr4	103146036	Silent	NA	I1402I	0.34
UCEC	chr4	103148916	Silent	rs751590849	S1257S	0.48
UCEC	chr4	103138444	Silent	novel	R2070R	0.25
UCEC	chr4	103109071	Silent	novel	S2581S	0.13
UCEC	chr4	103144482	Missense_Mutation	rs781248304	T1665M	0.43
UCEC	chr4	103147453	Missense_Mutation	novel	S1346Y	0.47
UCEC	chr4	103145238	Missense_Mutation	rs749051815	R1557C	0.51
UCEC	chr4	103151320	Nonsense_Mutation	novel	E1099*	0.49
UCEC	chr4	103153167	Silent	novel	I1039I	0.52
UCEC	chr4	103158783	Missense_Mutation	novel	T902M	0.16
UCEC	chr4	103174819	Nonsense_Mutation	novel	E522*	0.38
UCEC	chr4	103114528	Frame_Shift_Ins	novel	*E2490Qfs14**	0.05
UCEC	chr4	103149268	Nonsense_Mutation	novel	*T1179_E1180insSFQVYLETKHI**	0.06
UCEC	chr4	103158720	In_Frame_Ins	novel	E922_E923insGNPLCNGLNFKLQQTLE	0.04
UCEC	chr4	103182834	Silent	novel	G297G	0.47
UCEC	chr4	103122873	Nonsense_Mutation	novel	E2381*	0.08
UCEC	chr4	103140007	Frame_Shift_Del	NA	*I1996Lfs7**	0.41
UCEC	chr4	103122888	Missense_Mutation	rs777495974	T2376A	0.49
UCEC	chr4	103139911	Missense_Mutation	novel	H2028N	0.37
UCEC	chr4	103140375	Missense_Mutation	novel	L1932I	0.5
UCEC	chr4	103144363	Missense_Mutation	novel	L1705F	0.5
UCEC	chr4	103145962	Missense_Mutation	novel	S1427F	0.27
UCEC	chr4	103153122	Silent	novel	E1054E	0.08
UCEC	chr4	103175978	Silent	novel	A487A	0.39
UCEC	chr4	103182818	Missense_Mutation	rs115429647	R303C	0.25
UCEC	chr4	103120287	Missense_Mutation	novel	A2397V	0.2
UCEC	chr4	103138413	Missense_Mutation	novel	L2081V	0.13
UCEC	chr4	103141905	Silent	novel	L1770L	0.1
UCEC	chr4	103145123	Missense_Mutation	novel	M1595R	0.19
UCEC	chr4	103196250	Missense_Mutation	NA	R51C	0.17
UCEC	chr4	103109081	Missense_Mutation	novel	Q2578R	0.45
UCEC	chr4	103147634	Missense_Mutation	NA	H1286Y	0.54
UCEC	chr4	103148916	Silent	rs751590849	S1257S	0.4
UCEC	chr4	103180330	Missense_Mutation	rs778023977	T408M	0.31
UCEC	chr4	103148915	Missense_Mutation	rs200458836	V1258I	0.29
UCEC	chr4	103144482	Missense_Mutation	rs781248304	T1665M	0.23
UCEC	chr4	103133883	Missense_Mutation	NA	S2178G	0.11
UCEC	chr4	103114528	Frame_Shift_Ins	novel	*E2490Lfs39**	0.05
UCEC	chr4	103194653	Missense_Mutation	novel	E170A	0.5
UCEC	chr4	103160693	Missense_Mutation	rs756823638	R740W	0.29
UCEC	chr4	103174831	Nonsense_Mutation	novel	R518*	0.36
UCEC	chr4	103159035	Missense_Mutation	NA	S859L	0.22
UCEC	chr4	103136199	Missense_Mutation	novel	L2155R	0.08
UCEC	chr4	103151258	Silent	novel	C1119C	0.1
UCEC	chr4	103153128	Missense_Mutation	novel	K1052N	0.16
UCEC	chr4	103139958	Missense_Mutation	novel	S2012F	0.34
UCEC	chr4	103145902	Missense_Mutation	novel	L1447P	0.3
UCEC	chr4	103183256	Nonsense_Mutation	novel	R260*	0.2
UCEC	chr4	103109060	Frame_Shift_Ins	novel	*K2585Ifs12**	0.04
UCEC	chr4	103109062	Frame_Shift_Ins	novel	*K2585Nfs10**	0.03
UCEC	chr4	103181382	In_Frame_Ins	novel	K346delinsNL	0.05
UCEC	chr4	103181383	Nonsense_Mutation	novel	K346delinsISNYAILLDC*	0.05
UCEC	chr4	103132756	Frame_Shift_Ins	novel	*N2287Kfs8**	0.28
UCEC	chr4	103145106	Missense_Mutation	NA	A1601T	0.34
UCEC	chr4	103196249	Missense_Mutation	NA	R51H	0.24
UCEC	chr4	103114528	Frame_Shift_Ins	novel	*E2490Ffs38**	0.08
UCEC	chr4	103139836	Frame_Shift_Del	novel	*M2053Wfs7**	0.37
UCEC	chr4	103148945	Nonsense_Mutation	novel	Q1248*	0.17
UCEC	chr4	103196817	Silent	novel	Y30Y	0.36
UCEC	chr4	103143372	Missense_Mutation	NA	H1727R	0.27
UCEC	chr4	103133794	Silent	rs748139732	E2207E	0.35
UCEC	chr4	103108839	Missense_Mutation	rs774765853	R2659C	0.35
UCEC	chr4	103147480	Missense_Mutation	NA	F1337C	0.07
UCEC	chr4	103149215	Missense_Mutation	rs770112551	S1197Y	0.41
UCEC	chr4	103195215	Missense_Mutation	NA	L126I	0.34
UCEC	chr4	103153166	Nonsense_Mutation	novel	E1040*	0.16
UCEC	chr4	103145212	Silent	novel	Q1565Q	0.11
UCEC	chr4	103144464	Missense_Mutation	NA	T1671I	0.37
UCEC	chr4	103147480	Missense_Mutation	NA	F1337C	0.31
UCEC	chr4	103148956	Missense_Mutation	NA	L1244R	0.35
UCEC	chr4	103153144	Missense_Mutation	NA	S1047Y	0.27
UCEC	chr4	103114528	Frame_Shift_Ins	novel	*E2490Qfs14**	0.03
UCEC	chr4	103141057	Frame_Shift_Del	NA	*D1838Mfs15**	0.44
UCEC	chr4	103177017	Silent	NA	C424C	0.3
UCEC	chr4	103195162	Silent	NA	L143L	0.25
UCEC	chr4	103195999	Frame_Shift_Ins	novel	*T93Nfs20**	0.32
UCEC	chr4	103122932	Missense_Mutation	novel	P2361L	0.36
UCEC	chr4	103139844	Missense_Mutation	novel	S2050Y	0.42
UCEC	chr4	103177034	Nonsense_Mutation	novel	R419*	0.31
UCEC	chr4	103196187	Missense_Mutation	rs138076049	D72N	0.51
UCEC	chr4	103106263	Missense_Mutation	novel	A2689T	0.43
UCEC	chr4	103110972	Missense_Mutation	novel	P2527L	0.32
UCEC	chr4	103136250	Missense_Mutation	novel	V2138G	0.22
UCEC	chr4	103139848	Nonsense_Mutation	novel	E2049*	0.31
UCEC	chr4	103161116	Missense_Mutation	novel	T701A	0.33
UCEC	chr4	103174873	Missense_Mutation	NA	R504C	0.38
UCEC	chr4	103182843	Missense_Mutation	novel	N294K	0.48
UCEC	chr4	103140007	Frame_Shift_Del	NA	*I1996Lfs7**	0.14
UCS	chr4	103139962	Missense_Mutation	novel	L2011V	0.33
UVM	chr4	103153171	Missense_Mutation	novel	I1038T	0.5
UVM	chr4	103141750	Missense_Mutation	novel	K1821N	0.6

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
LIHC	DEL	0.4324	7.0927e-07
LUAD	DEL	0.1919	0.050802
MESO	DEL	0.4023	0.075661

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0059	Kaplan-Meier Survival Analysis
KIRC	0.00014	Kaplan-Meier Survival Analysis
SARC	0.0035	Kaplan-Meier Survival Analysis
MESO	0.00018	Kaplan-Meier Survival Analysis
ACC	0.0001	Kaplan-Meier Survival Analysis
PRAD	0.023	Kaplan-Meier Survival Analysis
KIRP	0.00011	Kaplan-Meier Survival Analysis
COAD	0.026	Kaplan-Meier Survival Analysis
PAAD	0.0001	Kaplan-Meier Survival Analysis
PCPG	0.016	Kaplan-Meier Survival Analysis
KICH	0.0029	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
CHOL	0.05	Kaplan-Meier Survival Analysis
LUAD	0.0001	Kaplan-Meier Survival Analysis
UVM	0.012	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000138778 (Gene tree)
Gene ID: 1062
Gene Symbol: CENPE
Alias: KIF10|PPP1R61
Full Name: centromere protein E
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 92,604 bases
Position: chr4:103,105,806-103,198,409
Accession: 1856
RBP type: non-canonical RBP
Summary: Centrosome-associated protein E (CENPE) is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centrosome-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. This protein is required for stable spindle microtubule capture at kinetochores which is a necessary step in chromosome alignment during prometaphase. This protein also couples chromosome position to microtubule depolymerizing activity. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Nov 2014]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

EuRBPDB

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Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

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