EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
22155184	β-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cells.	Gastroenterology	2012 Mar	Satow R	doi: 10.1053/j.gastro.2011.11.041
20699642	Regulation of the PML tumor suppressor in drug-induced senescence of human normal and cancer cells by JAK/STAT-mediated signaling.	Cell Cycle	2010 Aug 1	Hubackova S	doi: 10.4161/cc.9.15.12521
18039859	Degradation of the tumor suppressor PML by Pin1 contributes to the cancer phenotype of breast cancer MDA-MB-231 cells.	Mol Cell Biol	2008 Feb	Reineke EL	-
28691927	Ubiquitination of tumor suppressor PML regulates prometastatic and immunosuppressive tumor microenvironment.	J Clin Invest	2017 Aug 1	Wang YT	doi: 10.1172/JCI89957
18856066	[Increase of BIRC5 gene expression in non-small cell lung cancer and esophageal squamous cell carcinoma does not correlate with expression of genes SMAC/DIABLO and PML encoding its inhibitors].	Mol Biol (Mosk)	2008 Jul-Aug	Vashlia NA	-
26510911	Arsenic trioxide disrupts glioma stem cells via promoting PML degradation to inhibit tumor growth.	Oncotarget	2015 Nov 10	Zhou W	doi: 10.18632/oncotarget.5836.
14970276	Loss of the tumor suppressor PML in human cancers of multiple histologic origins.	J Natl Cancer Inst	2004 Feb 18	Gurrieri C	-
27545895	PML at Mitochondria-Associated Membranes Is Critical for the Repression of Autophagy and Cancer Development.	Cell Rep	2016 Aug 30	Missiroli S	doi: 10.1016/j.celrep.2016.07.082
24038216	The tumor suppressor gene DAPK2 is induced by the myeloid transcription factors PU.1 and C/EBPα during granulocytic differentiation but repressed by PML-RARα in APL.	J Leukoc Biol	2014 Jan	Humbert M	doi: 10.1189/jlb.1112608
25908860	PML induces compaction, TRF2 depletion and DNA damage signaling at telomeres and promotes their alternative lengthening.	J Cell Sci	2015 May 15	Osterwald S	doi: 10.1242/jcs.148296
25457157	Prognostic significance of promyelocytic leukemia expression in gastrointestinal stromal tumor; integrated proteomic and transcriptomic analysis.	Cancer Sci	2015 Jan	Ichikawa H	doi: 10.1111/cas.12565
19111660	PML, YAP, and p73 are components of a proapoptotic autoregulatory feedback loop.	Mol Cell	2008 Dec 26	Lapi E	doi: 10.1016/j.molcel.2008.11.019.
21840486	A Cullin3-KLHL20 Ubiquitin ligase-dependent pathway targets PML to potentiate HIF-1 signaling and prostate cancer progression.	Cancer Cell	2011 Aug 16	Yuan WC	doi: 10.1016/j.ccr.2011.07.008.
16924230	Apoptin is modified by SUMO conjugation and targeted to promyelocytic leukemia protein nuclear bodies.	Oncogene	2007 Mar 8	Janssen K	-
17428679	PML protein association with specific nucleolar structures differs in normal, tumor and senescent human cells.	J Struct Biol	2007 Jul	Janderov??-Rossmeislov?? L	-
21803845	PMLRARα binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo.	Blood	2011 Sep 15	Tao RH	doi: 10.1182/blood-2011-04-349670
15273249	Promyelocytic leukemia is a direct inhibitor of SAPK2/p38 mitogen-activated protein kinase.	J Biol Chem	2004 Sep 24	Shin J	-
19339552	Cell-cycle regulation and dynamics of cytoplasmic compartments containing the promyelocytic leukemia protein and nucleoporins.	J Cell Sci	2009 Apr 15	Jul-Larsen A	doi: 10.1242/jcs.040840.
26041820	PML/RARα-Regulated miR-181a/b Cluster Targets the Tumor Suppressor RASSF1A in Acute Promyelocytic Leukemia.	Cancer Res	2015 Aug 15	Bruer-Hartmann D	doi: 10.1158/0008-5472.CAN-14-3521
22906876	Association of promyelocytic leukemia protein with expression of IL-6 and resistance to treatment in multiple myeloma.	Acta Haematol	2012	Ohgiya D	doi: 10.1159/000339486
23430110	Selective inhibition of the NLRP3 inflammasome by targeting to promyelocytic leukemia protein in mouse and human.	Blood	2013 Apr 18	Lo YH	doi: 10.1182/blood-2012-05-432104
22167334	No evidence for PML-RARa bcr1 fusion gene in colorectal cancer.	Mol Biol Rep	2012 May	Herreros-Villanueva M	doi: 10.1007/s11033-011-1337-6
17441430	[Expression of PML in carcinogenesis of laryngocarcinoma and nasopharyngeal carcinoma].	Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi	2007 Feb	Chen W	-
18566754	CK2 mediates phosphorylation and ubiquitin-mediated degradation of the PML tumor suppressor.	Mol Cell Biochem	2008 Sep	Scaglioni PP	doi: 10.1007/s11010-008-9812-7
27553708	Stratification and therapeutic potential of PML in metastatic breast cancer.	Nat Commun	2016 Aug 24	Mart??n-Mart??n N	doi: 10.1038/ncomms12595.
18024792	Chromatin modifications induced by PML-RARalpha repress critical targets in leukemogenesis as analyzed by ChIP-Chip.	Blood	2008 Mar 1	Hoemme C	-
19487292	Promyelocytic leukemia protein is required for gain of function by mutant p53.	Cancer Res	2009 Jun 1	Haupt S	doi: 10.1158/0008-5472.CAN-08-4010.
25032863	Deacetylation of the tumor suppressor protein PML regulates hydrogen peroxide-induced cell death.	Cell Death Dis	2014 Jul 17	Guan D	doi: 10.1038/cddis.2014.185.
22022583	Loss of the promyelocytic leukemia protein in gastric cancer: implications for IP-10 expression and tumor-infiltrating lymphocytes.	PLoS One	2011	Kim HJ	doi: 10.1371/journal.pone.0026264
18689862	Promyelocytic leukemia (PML) gene expression is a prognostic factor in ampullary cancer patients.	Ann Oncol	2009 Jan	Vincenzi B	doi: 10.1093/annonc/mdn558
22886304	A metabolic prosurvival role for PML in breast cancer.	J Clin Invest	2012 Sep	Carracedo A	doi: 10.1172/JCI62129
21042751	Telomerase suppression initiates PML-dependent p53 activation to inhibit bladder cancer cell growth.	Oncol Rep	2010 Dec	Xue Y	-
20625391	Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer.	PLoS One	2010 Jul 2	Hung MS	doi: 10.1371/journal.pone.0011418.
18298799	Modulation of M2-type pyruvate kinase activity by the cytoplasmic PML tumor suppressor protein.	Genes Cells	2008 Mar	Shimada N	doi: 10.1111/j.1365-2443.2008.01165.x.
25971581	Promyelocytic leukemia protein enhances apoptosis of gastric cancer cells through Yes-associated protein.	Tumour Biol	2015 Sep	Xu Z	doi: 10.1007/s13277-015-3539-3
24548562	PML tumour suppression and beyond: therapeutic implications.	FEBS Lett	2014 Aug 19	Gamell C	doi: 10.1016/j.febslet.2014.02.007
14715247	Androgen suppresses PML protein expression in prostate cancer CWR22R cells.	Biochem Biophys Res Commun	2004 Jan 30	Yang L	-
18716620	The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network.	Nature	2008 Oct 9	Song MS	doi: 10.1038/nature07290
19728758	Germline variants of the promyelocytic leukemia tumor suppressor gene in patients with familial cancer.	Neoplasma	2009	Plevova P	-
28332630	PML nuclear bodies contribute to the basal expression of the mTOR inhibitor DDIT4.	Sci Rep	2017 Mar 23	Salsman J	doi: 10.1038/srep45038.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr15	74043054	Silent	novel	T592T	0.13
ACC	chr15	74022967	Nonsense_Mutation	novel	Q248*	0.42
BLCA	chr15	74044505	Missense_Mutation	novel	E716K	0.28
BLCA	chr15	74036028	Intron	novel		0.25
BLCA	chr15	74024964	Intron	novel		0.4
BLCA	chr15	74034464	Intron	novel		0.27
BLCA	chr15	74035844	Intron	novel		0.06
BLCA	chr15	74024933	Splice_Region	novel		0.17
BLCA	chr15	73998298	Missense_Mutation	NA	E142Q	0.19
BLCA	chr15	74023312	Missense_Mutation	NA	E363K	0.07
BLCA	chr15	74035178	Intron	novel		0.61
BLCA	chr15	74035275	Intron	novel		0.49
BLCA	chr15	74044610	Missense_Mutation	rs760154145	R751C	0.37
BLCA	chr15	74044628	Missense_Mutation	NA	L757F	0.15
BLCA	chr15	74023312	Missense_Mutation	NA	E363K	0.33
BLCA	chr15	73998374	Missense_Mutation	novel	A167G	0.13
BLCA	chr15	74034566	Intron	novel		0.16
BRCA	chr15	74034426	Intron	novel		0.21
BRCA	chr15	74032574	Splice_Region	rs543631733	P419P	0.29
BRCA	chr15	74025286	Intron	novel		1
BRCA	chr15	74044537	Silent	novel	L726L	0.13
BRCA	chr15	74035130	Intron	novel		0.51
BRCA	chr15	74024901	Missense_Mutation	NA	P410A	0.26
BRCA	chr15	74034969	Intron	novel		0.19
BRCA	chr15	74034469	Intron	novel		0.26
BRCA	chr15	74036060	Intron	NA		0.12
BRCA	chr15	74035638	Intron	rs148418079		0.21
CESC	chr15	74034522	Missense_Mutation	NA	E568K	0.16
CESC	chr15	74023063	Missense_Mutation	novel	R280C	0.64
CESC	chr15	74023120	Missense_Mutation	NA	E299Q	0.19
CESC	chr15	73998376	Missense_Mutation	NA	E168K	0.2
CESC	chr15	74034470	Splice_Region	rs780450207		0.52
CESC	chr15	74035501	Intron	novel		0.45
CESC	chr15	74044580	Missense_Mutation	rs769540520	R741C	0.13
CESC	chr15	74022900	Silent	NA	L225L	0.36
CESC	chr15	74023198	Missense_Mutation	rs765869727	R325C	0.28
CESC	chr15	74023240	Missense_Mutation	novel	Y339N	0.21
CESC	chr15	74044325	Missense_Mutation	novel	E656Q	0.21
CESC	chr15	73994861	Missense_Mutation	NA	R17W	0.52
CESC	chr15	74033182	Silent	novel	Q475Q	0.32
CESC	chr15	74035835	Intron	novel		0.29
CESC	chr15	74024901	Missense_Mutation	novel	P410S	0.18
COAD	chr15	73998248	Missense_Mutation	novel	A125V	0.11
COAD	chr15	73994792	5'UTR	novel		0.34
COAD	chr15	73998075	Silent	rs374118853	P67P	0.35
COAD	chr15	74035315	Intron	novel		0.29
COAD	chr15	74024903	Silent	NA	P410P	0.29
COAD	chr15	74035461	Intron	novel		0.22
COAD	chr15	74023400	Frame_Shift_Ins	NA	*K394Efs22**	0.53
COAD	chr15	74044367	Missense_Mutation	rs202099881	R670C	0.24
COAD	chr15	73994885	Frame_Shift_Del	NA	*E27Rfs71**	0.43
COAD	chr15	74035315	Intron	novel		0.41
COAD	chr15	74023027	Missense_Mutation	novel	L268V	0.69
COAD	chr15	74043193	Intron	NA		0.2
COAD	chr15	74035406	Intron	novel		0.35
COAD	chr15	73998139	Missense_Mutation	NA	P89T	0.35
COAD	chr15	74032598	Silent	NA	A427A	0.4
COAD	chr15	74044562	Missense_Mutation	NA	A735T	0.13
COAD	chr15	74044260	Missense_Mutation	NA	S634I	0.2
COAD	chr15	73998232	Missense_Mutation	rs141544943	R120W	0.24
COAD	chr15	73998382	Missense_Mutation	NA	R170C	0.27
COAD	chr15	74044371	Missense_Mutation	novel	R671L	0.06
COAD	chr15	74034485	Silent	rs139324287	R555R	0.09
COAD	chr15	74022855	Silent	rs767815962	P210P	0.68
COAD	chr15	74035227	Intron	NA		0.29
COAD	chr15	74043326	Intron	novel		0.61
COAD	chr15	73998457	Missense_Mutation	NA	R195C	0.33
COAD	chr15	74036084	Intron	rs747902260		0.22
COAD	chr15	74044270	Silent	rs148185755	R637R	0.13
ESCA	chr15	74043055	Missense_Mutation	novel	L593I	0.5
ESCA	chr15	74044639	Silent	novel	S760S	0.35
ESCA	chr15	74035315	Intron	novel		0.12
ESCA	chr15	73998146	Missense_Mutation	novel	C91F	0.08
ESCA	chr15	73998389	Missense_Mutation	novel	Q172L	0.6
GBM	chr15	74035346	Intron	novel		0.38
GBM	chr15	73998181	Missense_Mutation	rs570405596	A103T	0.35
GBM	chr15	74035930	Intron	rs370446869		0.39
GBM	chr15	74034456	Intron	novel		0.04
GBM	chr15	74035536	Intron	novel		0.1
GBM	chr15	74044585	Silent	rs768548359	S742S	0.25
GBM	chr15	74023044	Silent	NA	A273A	0.58
HNSC	chr15	74036028	Intron	novel		0.19
HNSC	chr15	74035350	Intron	novel		0.34
HNSC	chr15	74035412	Intron	rs756641826		0.14
HNSC	chr15	74035376	Intron	novel		0.47
HNSC	chr15	74035723	Intron	novel		0.4
HNSC	chr15	74035871	Intron	novel		0.28
HNSC	chr15	74043246	Intron	novel		0.21
HNSC	chr15	74033310	Missense_Mutation	novel	S518L	0.23
HNSC	chr15	74033467	Intron	rs760193317		0.57
HNSC	chr15	74025052	Intron	novel		0.38
HNSC	chr15	74022909	In_Frame_Del	novel	I229del	0.17
HNSC	chr15	73998201	Silent	NA	F109F	0.31
KICH	chr15	74035637	Intron	rs778003774		0.24
KIRC	chr15	74023108	Missense_Mutation	NA	R295C	0.27
KIRC	chr15	74044345	Missense_Mutation	NA	F662L	0.25
KIRP	chr15	74035612	Intron	novel		0.31
KIRP	chr15	74023004	Missense_Mutation	novel	Q260P	0.29
KIRP	chr15	74033302	Silent	NA	K515K	0.25
LAML	chr15	74034567	Intron	novel		0.12
LGG	chr15	74036135	Intron	novel		0.06
LGG	chr15	73998382	Missense_Mutation	NA	R170C	0.41
LGG	chr15	74036157	Intron	novel		0.33
LGG	chr15	74044899	Missense_Mutation	novel	G847V	0.31
LGG	chr15	73998192	Silent	NA	N106N	0.06
LGG	chr15	74022983	Missense_Mutation	NA	A253D	0.38
LIHC	chr15	74044862	Frame_Shift_Del	novel	*P836Lfs52**	0.38
LIHC	chr15	74035944	Intron	novel		0.28
LIHC	chr15	74044714	Frame_Shift_Del	novel	*Q786Lfs11**	0.24
LIHC	chr15	73998090	Missense_Mutation	NA	C72W	0.19
LIHC	chr15	74032651	Nonsense_Mutation	novel	S445*	0.37
LUAD	chr15	74034542	Intron	novel		0.23
LUAD	chr15	74036145	Intron	novel		0.26
LUAD	chr15	74023134	Silent	NA	A303A	0.41
LUAD	chr15	74035814	Intron	novel		0.53
LUAD	chr15	74023018	Missense_Mutation	NA	V265F	0.78
LUAD	chr15	74034663	Intron	novel		0.25
LUAD	chr15	74035901	Intron	novel		0.12
LUAD	chr15	73998227	Missense_Mutation	novel	V118E	0.2
LUAD	chr15	74023001	Missense_Mutation	NA	A259V	0.18
LUAD	chr15	74044941	Missense_Mutation	NA	R861L	0.13
LUAD	chr15	74032579	Missense_Mutation	NA	E421V	0.34
LUAD	chr15	73998181	Missense_Mutation	NA	A103S	0.16
LUAD	chr15	74023290	Silent	novel	A355A	0.27
LUAD	chr15	74033237	Nonsense_Mutation	NA	E494*	0.34
LUAD	chr15	74035662	Intron	novel		0.33
LUAD	chr15	74044921	Missense_Mutation	novel	L854F	0.41
LUAD	chr15	74023340	Missense_Mutation	NA	R372L	0.07
LUAD	chr15	73998443	Missense_Mutation	novel	S190C	0.15
LUAD	chr15	74044929	Missense_Mutation	rs756426423	P857L	0.16
LUSC	chr15	74035038	Intron	novel		0.42
LUSC	chr15	74044225	Missense_Mutation	novel	Q622H	0.21
LUSC	chr15	74044630	Silent	novel	L757L	0.16
LUSC	chr15	74045056	3'UTR	novel		0.21
LUSC	chr15	74036016	Intron	novel		0.34
LUSC	chr15	74035445	Intron	novel		0.39
OV	chr15	73998008	In_Frame_Ins	novel	A45_P46insLSVSTF	0.12
OV	chr15	74044733	Missense_Mutation	rs61751125	R792W	0.38
OV	chr15	74036173	Intron	novel		0.3
OV	chr15	74022866	Missense_Mutation	rs750722602	S214L	0.3
OV	chr15	74025175	Intron	novel		0.25
OV	chr15	74035225	Intron	NA		0.08
PAAD	chr15	74033387	Missense_Mutation	novel	H544Y	0.15
PCPG	chr15	74044374	Missense_Mutation	novel	P672R	0.3
PRAD	chr15	74035209	Intron	rs372539605		0.27
PRAD	chr15	74043163	Intron	rs540260798		0.3
READ	chr15	74044811	Missense_Mutation	novel	G818R	0.24
READ	chr15	74033565	Intron	novel		0.6
READ	chr15	73998215	Missense_Mutation	NA	R114Q	0.24
READ	chr15	74034628	Intron	rs769598989		0.12
READ	chr15	73994771	5'UTR	novel		0.42
SARC	chr15	74023118	Missense_Mutation	novel	L298Q	0.09
SARC	chr15	74022875	Missense_Mutation	novel	L217H	0.35
SKCM	chr15	74035714	Intron	rs777860927		0.33
SKCM	chr15	74043191	Intron	novel		0.62
SKCM	chr15	74035653	Intron	novel		0.17
SKCM	chr15	74035207	Intron	novel		0.27
SKCM	chr15	74035196	Intron	rs749032616		0.94
SKCM	chr15	74044308	Missense_Mutation	NA	S650F	0.94
SKCM	chr15	74043156	Intron	novel		0.5
SKCM	chr15	74045017	3'UTR	rs553436075		0.52
SKCM	chr15	74034583	Intron	novel		0.32
SKCM	chr15	74034469	Intron	novel		0.34
SKCM	chr15	74035915	Intron	novel		0.36
SKCM	chr15	74035725	Intron	novel		0.38
SKCM	chr15	73998201	Silent	NA	F109F	0.54
SKCM	chr15	74044892	Missense_Mutation	NA	A845T	0.34
SKCM	chr15	74034570	Intron	novel		0.25
SKCM	chr15	74035412	Intron	rs756641826		0.39
SKCM	chr15	73998219	Silent	rs753820877	R115R	0.5
SKCM	chr15	74044363	Silent	NA	S668S	0.2
SKCM	chr15	73998126	Silent	rs369958078	S84S	0.53
SKCM	chr15	74043191	Intron	novel		0.3
SKCM	chr15	74035681	Intron	novel		0.1
SKCM	chr15	74036087	Intron	novel		0.21
SKCM	chr15	74034463	Intron	novel		0.27
SKCM	chr15	74034464	Intron	novel		0.27
SKCM	chr15	74034473	Splice_Region	novel		0.06
SKCM	chr15	74035783	Intron	rs145127312		0.3
SKCM	chr15	74035784	Intron	rs146867846		0.3
SKCM	chr15	74035595	Intron	novel		0.5
SKCM	chr15	74035755	Intron	novel		0.09
SKCM	chr15	74044695	Missense_Mutation	novel	A779V	0.42
SKCM	chr15	74044643	Missense_Mutation	novel	G762S	0.57
SKCM	chr15	74032705	Missense_Mutation	NA	S463F	0.33
SKCM	chr15	74033371	Silent	novel	F538F	0.35
SKCM	chr15	73998364	Missense_Mutation	novel	R164W	0.52
SKCM	chr15	74035639	Intron	novel		0.1
SKCM	chr15	73998017	Missense_Mutation	rs377614337	S48L	0.49
SKCM	chr15	74045060	3'UTR	novel		0.43
SKCM	chr15	74035221	Intron	novel		0.22
STAD	chr15	74034351	Intron	rs565949358		0.34
STAD	chr15	74022871	Missense_Mutation	novel	A216T	0.58
STAD	chr15	74035637	Intron	rs778003774		0.2
STAD	chr15	74035856	Intron	rs775134797		0.24
STAD	chr15	74035982	Intron	novel		0.19
STAD	chr15	74032672	Missense_Mutation	NA	V452A	0.28
STAD	chr15	74023370	Missense_Mutation	rs149871195	R382H	0.24
STAD	chr15	73998383	Missense_Mutation	rs200708179	R170H	0.33
STAD	chr15	74023372	Missense_Mutation	novel	L383M	0.44
STAD	chr15	74033404	Silent	rs748216241	A549A	0.11
STAD	chr15	74044245	Missense_Mutation	NA	A629V	0.39
STAD	chr15	74023303	Missense_Mutation	NA	R360C	0.15
STAD	chr15	74034628	Intron	NA		0.37
STAD	chr15	74022963	Silent	NA	A246A	0.24
STAD	chr15	74023133	Missense_Mutation	rs754797325	A303V	0.61
STAD	chr15	74035907	Intron	novel		0.4
STAD	chr15	73998458	Missense_Mutation	NA	R195H	0.13
STAD	chr15	74023096	Missense_Mutation	NA	R291W	0.16
STAD	chr15	73998125	Missense_Mutation	rs771298279	S84L	0.29
STAD	chr15	74035342	Intron	rs201226688		0.34
STAD	chr15	74034502	Missense_Mutation	novel	S561N	0.28
STAD	chr15	74035715	Intron	novel		0.16
STAD	chr15	73998123	Silent	rs572620428	A83A	0.12
STAD	chr15	74024911	Missense_Mutation	NA	P413L	0.24
STAD	chr15	74044703	Nonsense_Mutation	NA	Q782*	0.13
STAD	chr15	74023323	Missense_Mutation	NA	S366R	0.57
STAD	chr15	74035410	Intron	novel		0.21
STAD	chr15	74035315	Intron	novel		0.54
THCA	chr15	73998315	Silent	novel	L147L	0.16
UCEC	chr15	74023209	Silent	NA	T328T	0.73
UCEC	chr15	74025439	Intron	novel		1
UCEC	chr15	74022906	Silent	novel	C227C	0.57
UCEC	chr15	74044362	Missense_Mutation	novel	S668F	0.48
UCEC	chr15	74044585	Silent	rs768548359	S742S	0.31
UCEC	chr15	74044987	Missense_Mutation	novel	E876D	0.13
UCEC	chr15	74044446	Missense_Mutation	novel	R696M	0.63
UCEC	chr15	74033564	Intron	rs184340830		0.27
UCEC	chr15	74043261	Intron	novel		0.59
UCEC	chr15	74044743	Missense_Mutation	novel	A795V	0.55
UCEC	chr15	74033260	Missense_Mutation	NA	L501F	0.32
UCEC	chr15	74044913	Missense_Mutation	novel	G852C	0.47
UCEC	chr15	74045086	3'UTR	novel		0.38
UCEC	chr15	74022932	Missense_Mutation	novel	R236Q	0.38
UCEC	chr15	74034515	Silent	novel	S565S	0.08
UCEC	chr15	74034635	Intron	novel		0.41
UCEC	chr15	74035935	Intron	rs76608781		0.3
UCEC	chr15	74043188	Intron	novel		0.18
UCEC	chr15	74044474	Silent	novel	S705S	0.19
UCEC	chr15	74045152	3'UTR	novel		0.64
UCEC	chr15	73994804	5'UTR	novel		0.44
UCEC	chr15	74033231	Nonsense_Mutation	NA	E492*	0.25
UCEC	chr15	74036120	Intron	novel		0.2
UCEC	chr15	74035182	Intron	novel		0.24
UCEC	chr15	73998336	Silent	rs375933686	A154A	0.6
UCEC	chr15	73994778	5'UTR	novel		0.07
UCEC	chr15	74033607	Intron	novel		0.39
UCEC	chr15	74034609	Intron	novel		0.21
UCEC	chr15	73998303	Silent	rs772957093	C143C	0.36
UCEC	chr15	74023218	Silent	novel	A331A	0.42
UCEC	chr15	74044528	Silent	novel	S723S	0.25
UCEC	chr15	74022873	Silent	rs371576035	A216A	0.43
UCEC	chr15	73998126	Silent	rs369958078	S84S	0.33
UCEC	chr15	74032681	Missense_Mutation	NA	Y455F	0.3
UCEC	chr15	73994761	5'UTR	novel		0.07
UCEC	chr15	74022957	Silent	NA	T244T	0.55
UCEC	chr15	74033657	Intron	novel		0.2
UCEC	chr15	74034522	Missense_Mutation	NA	E568K	0.1
UCEC	chr15	74036245	Intron	novel		0.16
UCEC	chr15	74023353	Silent	novel	F376F	0.8
UCEC	chr15	74035852	Intron	novel		0.42
UCEC	chr15	74025002	Intron	novel		0.52
UCEC	chr15	74035254	Intron	rs779668164		0.37
UCEC	chr15	74034978	Intron	novel		0.11
UCEC	chr15	74035521	Intron	novel		0.27
UCEC	chr15	74035967	Intron	novel		0.06
UCEC	chr15	74034486	Missense_Mutation	rs746515572	V556I	0.36
UCEC	chr15	74034567	Intron	novel		0.59
UCEC	chr15	74036151	Intron	novel		0.29
UCEC	chr15	74044508	Missense_Mutation	rs367988522	R717C	0.48
UCEC	chr15	73994885	Frame_Shift_Del	NA	*E27Rfs71**	0.25
UCEC	chr15	74034485	Silent	rs139324287	R555R	0.27
UCEC	chr15	74043326	Intron	novel		0.16
UCEC	chr15	74034628	Intron	NA		0.38
UCEC	chr15	73998040	Missense_Mutation	rs147696900	R56C	0.31
UCEC	chr15	73994885	Frame_Shift_Del	NA	*E27Rfs71**	0.21
UCEC	chr15	74032671	Missense_Mutation	rs759404689	V452M	0.43
UCEC	chr15	74032683	Missense_Mutation	rs11555843	A456T	0.15
UCEC	chr15	74032674	Missense_Mutation	novel	P453S	0.26
UCEC	chr15	74044941	Missense_Mutation	NA	R861L	0.28
UCEC	chr15	73998288	Missense_Mutation	novel	F138L	0.52
UCEC	chr15	74035047	Intron	novel		0.63
UCEC	chr15	74034991	Intron	novel		0.18
UCEC	chr15	74033248	Missense_Mutation	novel	K497N	0.08
UCEC	chr15	73998075	Silent	rs374118853	P67P	0.34
UCEC	chr15	74035637	Intron	rs778003774		0.23
UCEC	chr15	74022915	Silent	NA	S230S	0.15
UCEC	chr15	74023303	Missense_Mutation	NA	R360C	0.7
UCEC	chr15	74035499	Intron	novel		0.07
UCEC	chr15	74044932	Missense_Mutation	rs79562667	A858V	0.47
UCEC	chr15	74044714	Silent	novel	V785V	0.5
UCEC	chr15	74035460	Intron	rs145160033		0.35
UCEC	chr15	74035650	Intron	novel		0.38
UCEC	chr15	73998018	Silent	rs545577011	S48S	0.38
UCEC	chr15	74023218	Silent	novel	A331A	0.35
UCS	chr15	74044269	Missense_Mutation	novel	R637P	0.22

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	AMP	0.1932	0.0058042
LGG	AMP	0.0136	0.19963
PAAD	AMP	0.0652	0.20695
PAAD	DEL	0.1087	0.13216

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0062	Kaplan-Meier Survival Analysis
KIRC	0.0035	Kaplan-Meier Survival Analysis
STAD	0.02	Kaplan-Meier Survival Analysis
MESO	0.034	Kaplan-Meier Survival Analysis
SKCM	0.00052	Kaplan-Meier Survival Analysis
BRCA	0.0067	Kaplan-Meier Survival Analysis
KIRP	0.024	Kaplan-Meier Survival Analysis
COAD	0.0069	Kaplan-Meier Survival Analysis
PAAD	0.0011	Kaplan-Meier Survival Analysis
KICH	0.044	Kaplan-Meier Survival Analysis
UCEC	0.015	Kaplan-Meier Survival Analysis
GBM	0.011	Kaplan-Meier Survival Analysis
DLBC	0.04	Kaplan-Meier Survival Analysis
LGG	0.00079	Kaplan-Meier Survival Analysis
UVM	0.00036	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000140464 (Gene tree)
Gene ID: 5371
Gene Symbol: PML
Alias: MYL|TRIM19|RNF71
Full Name: promyelocytic leukemia
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 53,147 bases
Position: chr15:73,994,673-74,047,819
Accession: 9113
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
9560216	Localization of nascent RNA and CREB binding protein with the PML-containing nuclear body.	Proc Natl Acad Sci U S A	1998 Apr 28	LaMorte VJ	-
26595369	Cumulus cell-conditioned medium supports embryonic stem cell differentiation to germ cell-like cells.	Reprod Fertil Dev	2017 Apr	Shah SM	doi: 10.1071/RD15159.
21115099	PML positively regulates interferon gamma signaling.	Biochimie	2011 Mar	El Bougrini J	doi: 10.1016/j.biochi.2010.11.005

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000564428	PML-211	1985	-	ENSP00000457023	585 (aa)	-	P29590
ENST00000566068	PML-216	834	-	ENSP00000458061	217 (aa)	-	H3BVD2
ENST00000565239	PML-213	783	-	ENSP00000456989	240 (aa)	-	H3BT29
ENST00000565317	PML-214	596	-	-	- (aa)	-	-
ENST00000354026	PML-203	2885	-	ENSP00000315434	781 (aa)	-	P29590
ENST00000395132	PML-205	1738	-	ENSP00000378564	435 (aa)	-	P29590
ENST00000268058	PML-201	4508	-	ENSP00000268058	882 (aa)	-	P29590
ENST00000395135	PML-206	2199	-	ENSP00000378567	633 (aa)	-	P29590
ENST00000436891	PML-208	3010	-	ENSP00000394642	560 (aa)	-	P29590
ENST00000435786	PML-207	3643	-	ENSP00000395576	611 (aa)	-	P29590
ENST00000569965	PML-221	2148	-	ENSP00000456486	560 (aa)	-	P29590
ENST00000562086	PML-209	2232	-	ENSP00000456329	110 (aa)	-	H3BRN3
ENST00000268059	PML-202	3029	-	ENSP00000268059	829 (aa)	-	P29590
ENST00000565898	PML-215	5393	-	ENSP00000455838	834 (aa)	-	P29590
ENST00000567606	PML-218	2042	-	ENSP00000457669	261 (aa)	-	H3BUJ5
ENST00000570213	PML-222	371	-	-	- (aa)	-	-
ENST00000569161	PML-219	675	-	-	- (aa)	-	-
ENST00000567543	PML-217	1404	-	ENSP00000456277	423 (aa)	-	P29590
ENST00000564725	PML-212	4620	-	-	- (aa)	-	-
ENST00000563500	PML-210	4502	-	ENSP00000457032	568 (aa)	-	H3BT57
ENST00000569477	PML-220	2251	-	ENSP00000455612	641 (aa)	-	P29590
ENST00000359928	PML-204	1726	-	ENSP00000353004	423 (aa)	-	P29590

Gene Model

Click here to download ENSG00000140464's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04120	Ubiquitin mediated proteolysis	KEGG
hsa04144	Endocytosis	KEGG
hsa05164	Influenza A	KEGG
hsa05168	Herpes simplex virus 1 infection	KEGG
hsa05200	Pathways in cancer	KEGG
hsa05202	Transcriptional misregulation in cancer	KEGG
hsa05221	Acute myeloid leukemia	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000140464	Blood Pressure	4.847e-005	19060910
ENSG00000140464	Body Height	2E-29	25282103
ENSG00000140464	Osteitis Deformans	2E-14	21623375
ENSG00000140464	Body Height	1E-15	20881960
ENSG00000140464	Myopia, Degenerative	5E-8	23049088

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000140464	rs5742915	15	74044292	T	Height	20881960	[NR] unit decrease	0.031	EFO_0004339
ENSG00000140464	rs8039584	15	74013625	?	Myopia (pathological)	23049088	[NR]		EFO_0004207
ENSG00000140464	rs743580	15	74035775	A	Accelerometer-based physical activity measurement (fraction of time with accelerations >425 milli-gravities)	29899525	fraction of time increase	0.025	EFO_0008002
ENSG00000140464	rs5742915	15	74044292	C	Paget's disease	21623375	[1.25-1.45]	1.34	EFO_0004261
ENSG00000140464	rs5742915	15	74044292	T	Height	25282103	[0.029-0.041] unit decrease	0.035	EFO_0004339
ENSG00000140464	rs743580	15	74035775	A	Physical activity (overall physical activity time)	30531941	[0.013-0.03] SD units increase	0.0215485	EFO_0008002
ENSG00000140464	rs5742915	15	74044292	?	Menarche (age at onset)	30595370			EFO_0004703
ENSG00000140464	rs9479	15	74036235	?	White blood cell count	30595370			EFO_0004308
ENSG00000140464	rs9479	15	74036235	?	Red blood cell count	30595370			EFO_0004305
ENSG00000140464	rs5742915	15	74044292	?	Fat-free mass	30593698	[0.079-0.165] unit increase	0.12192	EFO_0004995
ENSG00000140464	rs5742915	15	74044292	?	Lung function (FEV1/FVC)	30595370			EFO_0004713

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000140464's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000784	nuclear chromosome, telomeric region	26119943.	IDA	Component
GO:0000792	heterochromatin	-	IEA	Component
GO:0001666	response to hypoxia	16915281.	IDA	Process
GO:0001932	regulation of protein phosphorylation	-	ISS	Process
GO:0003677	DNA binding	-	IEA	Function
GO:0003713	transcription coactivator activity	21873635.	IBA	Function
GO:0005515	protein binding	9294197.10669754.10684855.11259576.11948183.12006491.12529400.12915590.14517282.14976184.15195100.15467728.15626733.16322229.16873060.16915281.17036045.18298799.18511908.20389280.20625391.20639899.20832753.21057547.21803845.21840486.21988832.21994459.22002537.22117195.22274616.22683601.22685230.22869143.22945642.24407287.25241761.25497731.25772236.27211601.29735542.	IPI	Function
GO:0005634	nucleus	9412458.22274616.	IDA	Component
GO:0005654	nucleoplasm	12915590.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005730	nucleolus	15195100.	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	18298799.	IDA	Component
GO:0005829	cytosol	-	ISS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006355	regulation of transcription, DNA-templated	21873635.	IBA	Process
GO:0006355	regulation of transcription, DNA-templated	23007646.	IMP	Process
GO:0006606	protein import into nucleus	-	IEA	Process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	-	IEA	Process
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	-	ISS	Process
GO:0007050	cell cycle arrest	21873635.	IBA	Process
GO:0007179	transforming growth factor beta receptor signaling pathway	-	IEA	Process
GO:0007182	common-partner SMAD protein phosphorylation	-	IEA	Process
GO:0008270	zinc ion binding	-	IEA	Function
GO:0008285	negative regulation of cell proliferation	12006491.	IMP	Process
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	21873635.	IBA	Process
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	-	IEA	Process
GO:0009411	response to UV	-	IEA	Process
GO:0010332	response to gamma radiation	-	IEA	Process
GO:0010522	regulation of calcium ion transport into cytosol	-	ISS	Process
GO:0010761	fibroblast migration	-	IEA	Process
GO:0016032	viral process	-	IEA	Process
GO:0016363	nuclear matrix	21873635.	IBA	Component
GO:0016525	negative regulation of angiogenesis	16915281.	IMP	Process
GO:0016605	PML body	21873635.	IBA	Component
GO:0016605	PML body	9412458.9448006.11331580.12917339.15195100.17081985.22155184.22869143.23007646.23431171.	IDA	Component
GO:0016605	PML body	10910364.	IDA	Component
GO:0016605	PML body	9230084.	TAS	Component
GO:0030099	myeloid cell differentiation	-	IEA	Process
GO:0030155	regulation of cell adhesion	-	IEA	Process
GO:0030308	negative regulation of cell growth	9448006.	IDA	Process
GO:0030578	PML body organization	21873635.	IBA	Process
GO:0030578	PML body organization	17081985.	IMP	Process
GO:0031625	ubiquitin protein ligase binding	12915590.	IPI	Function
GO:0031901	early endosome membrane	-	IEA	Component
GO:0032183	SUMO binding	21873635.	IBA	Function
GO:0032183	SUMO binding	17081985.17081986.	IPI	Function
GO:0032206	positive regulation of telomere maintenance	26119943.	IMP	Process
GO:0032469	endoplasmic reticulum calcium ion homeostasis	-	ISS	Process
GO:0032922	circadian regulation of gene expression	-	ISS	Process
GO:0034097	response to cytokine	9412458.	IDA	Process
GO:0042406	extrinsic component of endoplasmic reticulum membrane	-	ISS	Component
GO:0042752	regulation of circadian rhythm	-	ISS	Process
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	-	ISS	Process
GO:0042803	protein homodimerization activity	9230084.	IPI	Function
GO:0043153	entrainment of circadian clock by photoperiod	-	ISS	Process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	22406621.	IDA	Process
GO:0045087	innate immune response	21873635.	IBA	Process
GO:0045087	innate immune response	18248090.	IDA	Process
GO:0045165	cell fate commitment	-	IEA	Process
GO:0045892	negative regulation of transcription, DNA-templated	9448006.	IDA	Process
GO:0046332	SMAD binding	21873635.	IBA	Function
GO:0048146	positive regulation of fibroblast proliferation	-	IEA	Process
GO:0048384	retinoic acid receptor signaling pathway	-	IEA	Process
GO:0050713	negative regulation of interleukin-1 beta secretion	-	IEA	Process
GO:0051457	maintenance of protein location in nucleus	17332504.	IDA	Process
GO:0051607	defense response to virus	-	IEA	Process
GO:0060333	interferon-gamma-mediated signaling pathway	-	TAS	Process
GO:0060444	branching involved in mammary gland duct morphogenesis	-	IEA	Process
GO:0065003	protein-containing complex assembly	12915590.	IDA	Process
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	-	IEA	Process
GO:0071353	cellular response to interleukin-4	-	IEA	Process
GO:0090398	cellular senescence	22002537.22117195.23431171.	IDA	Process
GO:0097191	extrinsic apoptotic signaling pathway	-	IEA	Process
GO:1901796	regulation of signal transduction by p53 class mediator	-	TAS	Process
GO:1902187	negative regulation of viral release from host cell	21873635.	IBA	Process
GO:1902187	negative regulation of viral release from host cell	18248090.	IDA	Process
GO:1903508	positive regulation of nucleic acid-templated transcription	-	IEA	Process
GO:1990830	cellular response to leukemia inhibitory factor	-	IEA	Process
GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	15195100.	IMP	Process
GO:2000779	regulation of double-strand break repair	21639834.	IMP	Process
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	21803845.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.