EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27806339	The nuclear corepressor 1 and the thyroid hormone receptor β suppress breast tumor lymphangiogenesis.	Oncotarget	2016 Nov 29	Mart??nez-Iglesias O	doi: 10.18632/oncotarget.12978.
26729869	Autoregulatory loop of nuclear corepressor 1 expression controls invasion, tumor growth, and metastasis.	Proc Natl Acad Sci U S A	2016 Jan 19	Mart??nez-Iglesias OA	doi: 10.1073/pnas.1520469113
21143702	Expression of nuclear receptor corepressors and class I histone deacetylases in astrocytic gliomas.	Cancer Sci	2011 Feb	Campos B	doi: 10.1111/j.1349-7006.2010.01792.x
26589942	PDCD2 and NCoR1 as putative tumor suppressors in gastric gastrointestinal stromal tumors.	Cell Oncol (Dordr)	2016 Apr	Wang W	doi: 10.1007/s13402-015-0258-0
20466759	Elevated NCOR1 disrupts PPARalpha/gamma signaling in prostate cancer and forms a targetable epigenetic lesion.	Carcinogenesis	2010 Sep	Battaglia S	doi: 10.1093/carcin/bgq086
25823659	Cytoplasmic accumulation of NCoR in malignant melanoma: consequences of altered gene repression and prognostic significance.	Oncotarget	2015 Apr 20	Gallardo F	-
22622808	Estrogen receptor beta binds Sp1 and recruits a corepressor complex to the estrogen receptor alpha gene promoter.	Breast Cancer Res Treat	2012 Jul	Bartella V	doi: 10.1007/s10549-012-2090-9
15802375	Cell cycle progression stimulated by tamoxifen-bound estrogen receptor-alpha and promoter-specific effects in breast cancer cells deficient in N-CoR and SMRT.	Mol Endocrinol	2005 Jun	Keeton EK	-
22675025	Nuclear hormone receptor corepressor promotes esophageal cancer cell invasion by transcriptional repression of interferon-γ-inducible protein 10 in a casein kinase 2-dependent manner.	Mol Biol Cell	2012 Aug	Yoo JY	-
21525722	Expression of ERβ and its co-regulators p300 and NCoR in human transitional cell bladder cancer.	Urol Int	2011	Kontos S	doi: 10.1159/000324262
23129261	Protein kinase A phosphorylates NCoR to enhance its nuclear translocation and repressive function in human prostate cancer cells.	J Cell Physiol	2013 Jun	Choi HK	doi: 10.1002/jcp.24269.
21966475	Role of chaperone mediated autophagy (CMA) in the degradation of misfolded N-CoR protein in non-small cell lung cancer (NSCLC) cells.	PLoS One	2011	Ali AB	doi: 10.1371/journal.pone.0025268
19781322	Nuclear corepressor 1 expression predicts response to first-line endocrine therapy for breast cancer patients on relapse.	Chin Med J (Engl)	2009 Aug 5	Zhang ZH	-
27880911	USP44 Is an Integral Component of N-CoR that Contributes to Gene Repression by Deubiquitinating Histone H2B.	Cell Rep	2016 Nov 22	Lan X	doi: 10.1016/j.celrep.2016.10.076.
26968201	Nuclear Receptor Corepressor 1 Expression and Output Declines with Prostate Cancer Progression.	Clin Cancer Res	2016 Aug 1	Lopez SM	doi: 10.1158/1078-0432.CCR-15-1983

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr17	16065672	Missense_Mutation	novel	Q1588H	0.14
BLCA	chr17	16171921	Missense_Mutation	novel	S106L	0.33
BLCA	chr17	16171918	In_Frame_Del	novel	H101_K107delinsQ	0.29
BLCA	chr17	16186635	Missense_Mutation	novel	S54L	0.18
BLCA	chr17	16057556	Nonsense_Mutation	novel	S2117*	0.35
BLCA	chr17	16057613	Missense_Mutation	novel	S2098L	0.33
BLCA	chr17	16058480	Missense_Mutation	novel	Q2001E	0.32
BLCA	chr17	16186644	Missense_Mutation	novel	S51N	0.13
BLCA	chr17	16070497	Nonsense_Mutation	novel	S1394*	0.13
BLCA	chr17	16048940	Nonsense_Mutation	novel	Y2147*	0.16
BLCA	chr17	16039575	Silent	NA	L2271L	0.26
BLCA	chr17	16091855	Splice_Region	novel		0.27
BLCA	chr17	16057584	Nonsense_Mutation	NA	Q2108*	0.32
BLCA	chr17	16032333	Missense_Mutation	novel	S2429L	0.65
BLCA	chr17	16101713	Missense_Mutation	novel	S743A	0.1
BLCA	chr17	16091983	Missense_Mutation	novel	A966T	0.37
BLCA	chr17	16119459	Nonsense_Mutation	NA	R627*	0.47
BLCA	chr17	16098479	Nonsense_Mutation	novel	S903*	0.09
BLCA	chr17	16061847	Missense_Mutation	novel	S1812F	0.51
BLCA	chr17	16126164	Nonsense_Mutation	NA	E518*	0.4
BLCA	chr17	16091821	Intron	NA		0.24
BLCA	chr17	16039540	Missense_Mutation	novel	G2283A	0.19
BLCA	chr17	16061761	Missense_Mutation	NA	E1841Q	0.51
BLCA	chr17	16034909	Missense_Mutation	novel	N2331H	0.35
BLCA	chr17	16158766	Silent	novel	E242E	0.31
BLCA	chr17	16064152	Missense_Mutation	novel	E1713K	0.05
BLCA	chr17	16070174	Missense_Mutation	novel	T1502S	0.2
BLCA	chr17	16047074	Missense_Mutation	novel	G2186R	0.26
BLCA	chr17	16073552	Missense_Mutation	NA	E1230K	0.22
BLCA	chr17	16040446	Missense_Mutation	rs571174228	T2243M	0.37
BLCA	chr17	16086391	Missense_Mutation	NA	R1023P	0.15
BLCA	chr17	16064105	Silent	novel	R1728R	0.38
BLCA	chr17	16080707	Silent	novel	L1066L	0.29
BLCA	chr17	16137413	Splice_Site	NA	X470_splice	0.18
BLCA	chr17	16071664	Frame_Shift_Ins	novel	*T1300Sfs7**	0.04
BLCA	chr17	16146455	Missense_Mutation	novel	E335Q	0.18
BLCA	chr17	16071497	Missense_Mutation	novel	P1355L	0.41
BLCA	chr17	16101260	Missense_Mutation	novel	E894Q	0.07
BLCA	chr17	16101521	Missense_Mutation	novel	E807Q	0.47
BLCA	chr17	16091866	Frame_Shift_Del	novel	*E1005Kfs10**	0.16
BLCA	chr17	16126139	Frame_Shift_Del	NA	*E526Kfs9**	0.11
BLCA	chr17	16072224	Silent	novel	L1272L	0.26
BLCA	chr17	16048967	Silent	novel	E2138E	0.31
BLCA	chr17	16080694	Nonsense_Mutation	novel	Q1071*	0.43
BLCA	chr17	16048880	Silent	rs747250940	L2167L	0.38
BLCA	chr17	16092029	Frame_Shift_Del	novel	*I950Mfs5**	0.63
BLCA	chr17	16071509	Frame_Shift_Ins	novel	*I1351Kfs4**	0.28
BLCA	chr17	16039642	Missense_Mutation	NA	S2249C	0.37
BLCA	chr17	16165076	Nonsense_Mutation	novel	S174*	0.26
BLCA	chr17	16071633	Missense_Mutation	novel	D1310H	0.22
BRCA	chr17	16086437	Nonsense_Mutation	NA	Q1008*	0.72
BRCA	chr17	16061832	Missense_Mutation	NA	A1817D	0.65
BRCA	chr17	16061833	Missense_Mutation	NA	A1817T	0.65
BRCA	chr17	16108807	Missense_Mutation	novel	E721K	0.33
BRCA	chr17	16108798	Nonsense_Mutation	NA	E724*	0.56
BRCA	chr17	16065554	Missense_Mutation	rs754505756	R1628C	0.22
BRCA	chr17	16075682	Missense_Mutation	NA	Q1174H	0.83
BRCA	chr17	16164902	Intron	novel		0.4
BRCA	chr17	16070163	Splice_Site	novel	X1505_splice	0.74
BRCA	chr17	16070257	Frame_Shift_Del	novel	*P1467Dfs3**	0.65
BRCA	chr17	16091945	Missense_Mutation	novel	Q978H	0.06
BRCA	chr17	16126142	Frame_Shift_Ins	NA	*T525Nfs11**	0.47
BRCA	chr17	16108901	Splice_Site	novel	X686_splice	0.86
BRCA	chr17	16101387	Silent	novel	E851E	0.04
BRCA	chr17	16126142	Frame_Shift_Ins	NA	*T525Nfs11**	0.34
BRCA	chr17	16072217	Nonsense_Mutation	NA	R1275*	0.57
BRCA	chr17	16165124	Missense_Mutation	NA	S158F	0.31
BRCA	chr17	16061722	Nonsense_Mutation	novel	R1854*	0.69
BRCA	chr17	16146521	Nonsense_Mutation	NA	Q313*	0.28
BRCA	chr17	16121130	Nonsense_Mutation	NA	E592*	0.53
BRCA	chr17	16080712	Frame_Shift_Ins	NA	*Y1065Afs7**	0.49
BRCA	chr17	16091994	Frame_Shift_Del	novel	*G956Dfs22**	0.53
BRCA	chr17	16108889	Missense_Mutation	NA	E693D	0.42
BRCA	chr17	16075627	Nonsense_Mutation	novel	E1193*	0.07
BRCA	chr17	16126125	Missense_Mutation	NA	E531Q	0.28
BRCA	chr17	16040486	Nonsense_Mutation	NA	Q2230*	0.55
BRCA	chr17	16061749	Missense_Mutation	NA	E1845K	0.15
BRCA	chr17	16080483	Missense_Mutation	NA	E1109K	0.68
BRCA	chr17	16158832	Silent	NA	E220E	0.51
BRCA	chr17	16034890	Missense_Mutation	NA	S2337F	0.37
BRCA	chr17	16058601	Splice_Site	NA	X1961_splice	0.33
BRCA	chr17	16165028	Frame_Shift_Del	novel	*V188Nfs10**	0.66
BRCA	chr17	16091861	Splice_Site	NA	X1006_splice	0.13
BRCA	chr17	16158834	Missense_Mutation	NA	E220K	0.28
BRCA	chr17	16079977	Missense_Mutation	novel	G1163D	0.09
BRCA	chr17	16194551	Missense_Mutation	novel	P7S	0.36
BRCA	chr17	16062118	Nonsense_Mutation	NA	Q1792*	0.39
BRCA	chr17	16071646	Silent	novel	T1305T	0.05
BRCA	chr17	16086373	Missense_Mutation	NA	P1029Q	0.14
BRCA	chr17	16079988	Silent	NA	P1159P	0.21
BRCA	chr17	16139187	Splice_Site	NA	X392_splice	0.29
BRCA	chr17	16165146	Missense_Mutation	rs367758096	G151S	0.18
BRCA	chr17	16171880	Nonsense_Mutation	NA	Q120*	0.25
BRCA	chr17	16171801	Splice_Site	NA	X145_splice	0.25
BRCA	chr17	16075560	Missense_Mutation	novel	K1215R	0.35
BRCA	chr17	16040469	Missense_Mutation	NA	I2235M	0.11
BRCA	chr17	16061761	Missense_Mutation	NA	E1841Q	0.36
BRCA	chr17	16058050	Nonsense_Mutation	novel	Q2009*	0.19
BRCA	chr17	16143697	Splice_Site	NA	X361_splice	0.35
BRCA	chr17	16040445	Frame_Shift_Ins	novel	*S2244Vfs5**	0.08
BRCA	chr17	16039608	Missense_Mutation	NA	N2260K	0.78
BRCA	chr17	16126142	Frame_Shift_Ins	NA	*T525Nfs11**	0.39
BRCA	chr17	16065584	Frame_Shift_Del	NA	*I1618Lfs8**	0.1
BRCA	chr17	16032429	Missense_Mutation	NA	P2397L	0.17
BRCA	chr17	16086322	Nonsense_Mutation	NA	S1046*	0.49
BRCA	chr17	16108903	Nonsense_Mutation	NA	K689*	0.53
BRCA	chr17	16062112	Nonsense_Mutation	NA	R1794*	0.5
BRCA	chr17	16061557	Missense_Mutation	NA	P1909S	0.2
BRCA	chr17	16062229	Missense_Mutation	NA	R1755C	0.2
BRCA	chr17	16065483	Splice_Site	NA	X1651_splice	0.31
CESC	chr17	16117909	Silent	NA	L678L	0.21
CESC	chr17	16101501	Silent	novel	P813P	0.44
CESC	chr17	16073565	Missense_Mutation	novel	I1225M	0.26
CESC	chr17	16071636	Missense_Mutation	novel	E1309K	0.18
CESC	chr17	16067964	Frame_Shift_Del	novel	*E1558Rfs57**	0.12
CESC	chr17	16073570	Splice_Site	NA	X1224_splice	0.4
CESC	chr17	16061477	Silent	novel	V1935V	0.33
CESC	chr17	16039498	Missense_Mutation	novel	A2297V	0.26
CESC	chr17	16040478	Silent	novel	G2232G	0.46
CESC	chr17	16064881	Missense_Mutation	novel	S1697F	0.39
CESC	chr17	16067964	Silent	novel	G1557G	0.17
CESC	chr17	16087307	Intron	novel		0.38
CESC	chr17	16092020	Silent	novel	P953P	0.29
CESC	chr17	16101495	Silent	rs139942816	P815P	0.44
CESC	chr17	16158807	Missense_Mutation	novel	E229K	0.32
CESC	chr17	16086315	Frame_Shift_Del	rs767736595	*K1048Nfs5**	0.21
CESC	chr17	16151977	Missense_Mutation	novel	D271H	0.34
CESC	chr17	16061454	Missense_Mutation	NA	S1943L	0.15
CESC	chr17	16032297	Silent	novel	*2441*	0.24
CESC	chr17	16075602	Missense_Mutation	NA	R1201K	0.28
CESC	chr17	16151595	Intron	novel		0.24
CESC	chr17	16062229	Missense_Mutation	NA	R1755C	0.19
CESC	chr17	16073535	Frame_Shift_Del	novel	*R1233Kfs5**	0.36
CESC	chr17	16098408	Silent	NA	L927L	0.38
CESC	chr17	16108897	Missense_Mutation	NA	R691C	0.17
CESC	chr17	16098437	Nonsense_Mutation	novel	S917*	0.07
CHOL	chr17	16073459	Missense_Mutation	novel	R1261G	0.47
CHOL	chr17	16126142	Frame_Shift_Ins	NA	*T525Nfs11**	0.33
COAD	chr17	16064938	Missense_Mutation	NA	I1678N	0.14
COAD	chr17	16065690	Silent	rs780188590	A1582A	0.34
COAD	chr17	16087336	Intron	novel		0.33
COAD	chr17	16065526	Frame_Shift_Del	novel	*P1637Qfs19**	0.14
COAD	chr17	16070421	Silent	rs143182424	P1419P	0.52
COAD	chr17	16068006	Silent	NA	S1543S	0.73
COAD	chr17	16032113	3'UTR	novel		0.35
COAD	chr17	16121226	Nonsense_Mutation	novel	E560*	0.24
COAD	chr17	16121061	Missense_Mutation	novel	P615A	0.19
COAD	chr17	16070181	Missense_Mutation	novel	M1499I	0.22
COAD	chr17	16065020	Splice_Site	novel	X1651_splice	0.68
COAD	chr17	16070354	Missense_Mutation	novel	E1442K	0.06
COAD	chr17	16101669	Silent	rs781757424	T757T	0.43
COAD	chr17	16121191	Frame_Shift_Del	NA	*R572Efs18**	0.07
COAD	chr17	16034878	Missense_Mutation	NA	G2341V	0.3
COAD	chr17	16101667	Missense_Mutation	NA	E758G	0.35
COAD	chr17	16108912	Missense_Mutation	novel	T686S	0.41
COAD	chr17	16046952	Missense_Mutation	NA	M2226I	0.21
COAD	chr17	16032375	Missense_Mutation	novel	Q2415R	0.28
COAD	chr17	16071436	Silent	NA	R1375R	0.39
COAD	chr17	16062126	Missense_Mutation	NA	P1789Q	0.21
COAD	chr17	16064964	Silent	novel	G1669G	0.35
COAD	chr17	16071626	Missense_Mutation	NA	L1312P	0.28
COAD	chr17	16121166	Missense_Mutation	NA	R580C	0.24
COAD	chr17	16146529	Missense_Mutation	NA	R310H	0.15
COAD	chr17	16034815	Missense_Mutation	novel	Y2362C	0.07
COAD	chr17	16108889	Silent	NA	E693E	0.31
COAD	chr17	16057953	Missense_Mutation	NA	Q2041R	0.09
COAD	chr17	16057628	Missense_Mutation	NA	V2093A	0.31
COAD	chr17	16171816	Missense_Mutation	NA	A141V	0.21
COAD	chr17	16080025	Missense_Mutation	NA	G1147E	0.12
COAD	chr17	16065553	Missense_Mutation	rs772605440	R1628H	0.05
COAD	chr17	16039466	Nonsense_Mutation	novel	R2308*	0.23
COAD	chr17	16058184	Intron	novel		0.26
COAD	chr17	16098390	Nonsense_Mutation	NA	R933*	0.26
COAD	chr17	16121065	Silent	rs145739289	P613P	0.13
COAD	chr17	16139094	Silent	rs761867754	G422G	0.09
COAD	chr17	16194626	5'UTR	novel		0.17
COAD	chr17	16146495	Frame_Shift_Del	NA	*V322Wfs4**	0.32
COAD	chr17	16032447	Missense_Mutation	NA	R2391Q	0.18
COAD	chr17	16048935	Missense_Mutation	NA	P2149H	0.28
COAD	chr17	16139166	Silent	novel	R398R	0.09
COAD	chr17	16108851	Missense_Mutation	novel	V706A	0.06
COAD	chr17	16080361	Intron	novel		0.3
COAD	chr17	16080707	Missense_Mutation	NA	L1066F	0.29
COAD	chr17	16057696	Silent	novel	S2070S	0.31
COAD	chr17	16070483	Missense_Mutation	NA	I1399V	0.32
COAD	chr17	16047082	Missense_Mutation	rs201721277	R2183H	0.15
COAD	chr17	16086361	Missense_Mutation	rs776976570	P1033L	0.16
COAD	chr17	16091919	Missense_Mutation	NA	C987Y	0.19
COAD	chr17	16194470	Missense_Mutation	NA	H34N	0.17
COAD	chr17	16101570	Silent	novel	A790A	0.11
ESCA	chr17	16032255	3'UTR	novel		0.92
ESCA	chr17	16091952	Missense_Mutation	novel	Q976P	0.14
ESCA	chr17	16139013	Silent	novel	K449K	0.15
ESCA	chr17	16040446	Missense_Mutation	novel	T2243K	0.26
ESCA	chr17	16101284	Missense_Mutation	novel	D886N	0.4
ESCA	chr17	16047004	Missense_Mutation	novel	K2209M	0.67
GBM	chr17	16061575	Missense_Mutation	novel	A1903T	0.42
GBM	chr17	16062267	Nonsense_Mutation	novel	S1742*	0.38
GBM	chr17	16075571	Silent	novel	I1211I	0.05
GBM	chr17	16158834	Missense_Mutation	NA	E220K	0.36
GBM	chr17	16070340	Silent	novel	S1446S	0.03
GBM	chr17	16068078	Silent	rs774605999	S1519S	0.39
GBM	chr17	16101698	Nonsense_Mutation	novel	E748*	0.44
GBM	chr17	16126142	Frame_Shift_Ins	NA	*T525Nfs11**	0.41
GBM	chr17	16171981	Missense_Mutation	novel	R86I	0.24
GBM	chr17	16217207	5'Flank	novel		0.46
GBM	chr17	16065586	Missense_Mutation	novel	Y1617F	0.16
GBM	chr17	16126132	Frame_Shift_Del	NA	*E529Kfs26**	0.67
GBM	chr17	16061632	Missense_Mutation	novel	S1884A	0.3
GBM	chr17	16137374	Missense_Mutation	novel	K482N	0.49
GBM	chr17	16186682	Silent	rs774156133	F38F	0.08
GBM	chr17	16039606	Missense_Mutation	novel	L2261H	0.05
GBM	chr17	16064137	Missense_Mutation	rs373216507	R1718W	0.4
GBM	chr17	16075688	Silent	novel	L1172L	0.11
GBM	chr17	16047028	Missense_Mutation	novel	T2201K	0.08
GBM	chr17	16070288	Missense_Mutation	novel	H1464D	0.08
HNSC	chr17	16039458	Missense_Mutation	novel	E2310D	0.22
HNSC	chr17	16039637	Missense_Mutation	novel	G2251C	0.44
HNSC	chr17	16121190	Nonsense_Mutation	NA	R572*	0.2
HNSC	chr17	16061749	Missense_Mutation	NA	E1845K	0.18
HNSC	chr17	16186651	Missense_Mutation	novel	E49K	0.09
HNSC	chr17	16034786	Missense_Mutation	novel	E2372K	0.39
HNSC	chr17	16080663	Missense_Mutation	NA	P1081L	0.22
HNSC	chr17	16067953	Missense_Mutation	novel	R1561Q	0.16
HNSC	chr17	16061530	Missense_Mutation	novel	E1918Q	0.24
HNSC	chr17	16039472	Missense_Mutation	novel	E2306K	0.05
HNSC	chr17	16039472	Missense_Mutation	novel	E2306K	0.14
HNSC	chr17	16080663	Missense_Mutation	NA	P1081L	0.1
HNSC	chr17	16057728	In_Frame_Ins	novel	I2059_T2060insPW	0.11
HNSC	chr17	16108843	Nonsense_Mutation	NA	Q709*	0.34
HNSC	chr17	16101738	Silent	novel	S734S	0.14
HNSC	chr17	16067953	Missense_Mutation	novel	R1561Q	0.35
HNSC	chr17	16108783	Splice_Region	novel		0.28
KIRC	chr17	16091970	Missense_Mutation	novel	S970L	0.06
KIRC	chr17	16061738	Missense_Mutation	NA	R1848S	0.38
KIRC	chr17	16061484	Missense_Mutation	rs762513108	I1933T	0.14
KIRC	chr17	16068274	Intron	novel		0.3
KIRC	chr17	16071448	Silent	NA	V1371V	0.11
KIRC	chr17	16048970	Silent	NA	P2137P	0.32
KIRC	chr17	16171882	Missense_Mutation	NA	F119Y	0.37
KIRC	chr17	16057695	Missense_Mutation	NA	Q2071K	0.33
KIRC	chr17	16117942	Silent	NA	F667F	0.29
KIRP	chr17	16121068	Silent	novel	P612P	0.25
KIRP	chr17	16068117	Silent	NA	T1506T	0.28
KIRP	chr17	16061420	Silent	novel	S1954S	0.27
KIRP	chr17	16101372	Missense_Mutation	novel	R856S	0.58
KIRP	chr17	16058493	Silent	novel	V1996V	0.09
KIRP	chr17	16048942	Missense_Mutation	novel	Y2147N	0.6
KIRP	chr17	16186635	Nonsense_Mutation	NA	S54*	0.34
KIRP	chr17	16058029	Missense_Mutation	novel	H2016Y	0.14
KIRP	chr17	16032448	Missense_Mutation	NA	R2391G	0.19
KIRP	chr17	16065638	Missense_Mutation	NA	Q1600K	0.25
LAML	chr17	16158794	Missense_Mutation	novel	R233L	0.03
LAML	chr17	16058008	Missense_Mutation	novel	S2023A	0.05
LGG	chr17	16075682	Silent	NA	Q1174Q	0.04
LGG	chr17	16071491	Missense_Mutation	NA	Q1357R	0.83
LGG	chr17	16032453	Missense_Mutation	novel	T2389I	0.35
LGG	chr17	16070339	Silent	novel	R1447R	0.39
LGG	chr17	16117929	Nonsense_Mutation	NA	R672*	0.1
LGG	chr17	16146466	Missense_Mutation	novel	R331M	0.56
LGG	chr17	16165115	Missense_Mutation	rs765365064	S161L	0.29
LGG	chr17	16068024	Silent	novel	G1537G	0.39
LGG	chr17	16040449	Missense_Mutation	NA	T2242S	0.06
LIHC	chr17	16137328	Missense_Mutation	novel	R498C	0.7
LIHC	chr17	16032482	Splice_Region	novel	G2379G	0.51
LIHC	chr17	16067913	Frame_Shift_Del	novel	*H1575Tfs40**	0.45
LIHC	chr17	16073522	Nonsense_Mutation	novel	E1240*	0.31
LIHC	chr17	16061732	Missense_Mutation	novel	E1850D	0.36
LIHC	chr17	16039580	In_Frame_Del	novel	N2260_A2270delinsT	0.08
LIHC	chr17	16126142	Frame_Shift_Ins	NA	*T525Nfs11**	0.83
LIHC	chr17	16139162	Missense_Mutation	novel	L400F	0.77
LUAD	chr17	16164892	Intron	novel		0.36
LUAD	chr17	16068100	Missense_Mutation	NA	S1512C	0.48
LUAD	chr17	16086431	Missense_Mutation	novel	A1010S	0.47
LUAD	chr17	16032295	3'UTR	novel		0.17
LUAD	chr17	16101807	Intron	novel		0.5
LUAD	chr17	16146469	Missense_Mutation	NA	R330L	0.4
LUAD	chr17	16121152	Frame_Shift_Del	novel	*I585Sfs5**	0.09
LUAD	chr17	16101743	Missense_Mutation	novel	P733A	0.39
LUAD	chr17	16071664	Frame_Shift_Ins	novel	*T1300Yfs2**	0.02
LUAD	chr17	16108897	Missense_Mutation	NA	R691C	0.8
LUAD	chr17	16032479	Silent	NA	S2380S	0.06
LUAD	chr17	16171949	Missense_Mutation	novel	S97T	0.08
LUAD	chr17	16046990	Missense_Mutation	rs763924640	R2214C	0.11
LUAD	chr17	16058512	Missense_Mutation	novel	Q1990L	0.13
LUAD	chr17	16101471	Silent	rs377605315	D823D	0.08
LUAD	chr17	16149474	Missense_Mutation	novel	R296G	0.96
LUAD	chr17	16061620	Missense_Mutation	NA	P1888S	0.26
LUAD	chr17	16101597	Missense_Mutation	novel	E781D	0.32
LUAD	chr17	16126200	Missense_Mutation	novel	A506S	0.24
LUAD	chr17	16151999	Splice_Site	novel	X264_splice	0.39
LUAD	chr17	16121195	Missense_Mutation	NA	R570L	0.27
LUAD	chr17	16101260	Missense_Mutation	novel	E894K	0.08
LUAD	chr17	16070232	Silent	novel	R1482R	0.05
LUAD	chr17	16101289	Missense_Mutation	novel	S884N	0.29
LUAD	chr17	16064070	Missense_Mutation	novel	P1740L	0.07
LUAD	chr17	16046974	Missense_Mutation	NA	S2219C	0.06
LUSC	chr17	16080663	Missense_Mutation	NA	P1081L	0.12
LUSC	chr17	16058114	Intron	novel		0.56
LUSC	chr17	16080628	Nonsense_Mutation	novel	Q1093*	0.28
LUSC	chr17	16171920	Silent	novel	S106S	0.31
LUSC	chr17	16068043	Missense_Mutation	rs151311067	A1531V	0.45
LUSC	chr17	16064933	Missense_Mutation	novel	Y1680D	0.26
LUSC	chr17	16108885	Missense_Mutation	novel	D695Y	0.44
LUSC	chr17	16101338	Missense_Mutation	NA	A868S	0.17
LUSC	chr17	16062179	Silent	novel	R1771R	0.08
LUSC	chr17	16186599	Missense_Mutation	novel	R66L	0.58
LUSC	chr17	16086361	Missense_Mutation	rs776976570	P1033L	0.3
LUSC	chr17	16080004	Missense_Mutation	novel	S1154L	0.06
LUSC	chr17	16164996	Nonsense_Mutation	novel	K201*	0.5
LUSC	chr17	16138158	Missense_Mutation	novel	K469N	0.37
LUSC	chr17	16057665	Missense_Mutation	novel	F2081I	0.6
LUSC	chr17	16048940	Nonsense_Mutation	NA	Y2147*	0.19
LUSC	chr17	16151983	Missense_Mutation	novel	P269T	0.41
LUSC	chr17	16194511	Missense_Mutation	NA	Y20F	0.21
LUSC	chr17	16121220	Missense_Mutation	NA	E562K	0.32
LUSC	chr17	16165015	Silent	novel	K194K	0.27
LUSC	chr17	16086331	Missense_Mutation	rs376522360	T1043I	0.29
LUSC	chr17	16146398	Missense_Mutation	novel	E354K	0.43
LUSC	chr17	16065520	Missense_Mutation	NA	E1639G	0.13
LUSC	chr17	16065521	Nonsense_Mutation	NA	E1639*	0.12
LUSC	chr17	16101560	Missense_Mutation	novel	E794K	0.17
LUSC	chr17	16061425	Missense_Mutation	novel	Q1953E	0.48
LUSC	chr17	16061566	Missense_Mutation	novel	D1906N	0.45
LUSC	chr17	16158827	Missense_Mutation	novel	P222L	0.23
LUSC	chr17	16101256	Frame_Shift_Del	novel	*P893Afs52**	0.05
LUSC	chr17	16164970	Intron	novel		0.14
MESO	chr17	16058571	Missense_Mutation	novel	S1970R	0.7
MESO	chr17	16058545	Missense_Mutation	novel	A1979V	0.24
MESO	chr17	16172020	Intron	novel		0.1
MESO	chr17	16158849	Nonsense_Mutation	novel	K215*	0.34
OV	chr17	16146543	Missense_Mutation	novel	Q305H	0.08
OV	chr17	16039520	In_Frame_Del	novel	E2280_M2290delinsV	0.16
OV	chr17	16061698	Missense_Mutation	novel	E1862Q	0.04
OV	chr17	16064989	Missense_Mutation	novel	T1661I	0.66
OV	chr17	16057529	Missense_Mutation	novel	D2126G	0.04
OV	chr17	16061762	Silent	novel	K1840K	0.22
OV	chr17	16032322	Nonsense_Mutation	novel	E2433*	0.1
OV	chr17	16071606	Frame_Shift_Ins	novel	*K1319Lfs17**	0.08
OV	chr17	16091980	Missense_Mutation	rs749822932	M967V	0.7
OV	chr17	16070276	Missense_Mutation	novel	K1468E	0.13
OV	chr17	16137371	Missense_Mutation	novel	K483N	0.56
OV	chr17	16070355	Silent	rs762689014	G1441G	0.13
OV	chr17	16101523	Missense_Mutation	novel	E806A	0.1
OV	chr17	16070486	Missense_Mutation	novel	A1398T	0.08
OV	chr17	16121153	Missense_Mutation	novel	R584L	0.18
PAAD	chr17	16086440	Missense_Mutation	novel	L1007I	0.23
PAAD	chr17	16121163	Missense_Mutation	novel	R581C	0.18
PAAD	chr17	16146502	Missense_Mutation	novel	E319G	0.21
PAAD	chr17	16171917	Missense_Mutation	novel	K107N	0.16
PAAD	chr17	16186663	Missense_Mutation	novel	S45P	0.13
PCPG	chr17	16091854	Intron	novel		0.08
PRAD	chr17	16068062	Nonsense_Mutation	NA	Q1525*	0.23
PRAD	chr17	16065002	Frame_Shift_Ins	novel	*N1657Qfs57**	0.33
PRAD	chr17	16061701	Missense_Mutation	rs543425229	S1861G	0.28
PRAD	chr17	16139142	Frame_Shift_Del	novel	*M406Ifs15**	0.33
PRAD	chr17	16086396	Silent	rs546064182	G1021G	0.35
PRAD	chr17	16061785	Frame_Shift_Del	NA	*Q1833Rfs17**	0.27
PRAD	chr17	16073544	Silent	NA	T1232T	0.07
PRAD	chr17	16067937	Silent	rs376520817	T1566T	0.42
READ	chr17	16101623	Nonsense_Mutation	NA	K773*	0.44
READ	chr17	16061710	Missense_Mutation	NA	A1858S	0.46
READ	chr17	16062111	Missense_Mutation	NA	R1794Q	0.42
READ	chr17	16080470	Missense_Mutation	rs150513105	R1113Q	0.39
READ	chr17	16080620	Missense_Mutation	novel	E1095D	0.42
READ	chr17	16139178	Missense_Mutation	novel	E394D	0.29
READ	chr17	16101524	Nonsense_Mutation	NA	E806*	0.16
READ	chr17	16108861	Missense_Mutation	NA	A703T	0.79
READ	chr17	16153367	Missense_Mutation	novel	F254C	0.07
SARC	chr17	16040457	Silent	novel	P2239P	0.08
SARC	chr17	16101669	Silent	rs781757424	T757T	0.29
SARC	chr17	16146466	Missense_Mutation	novel	R331K	0.13
SARC	chr17	16080509	Missense_Mutation	novel	A1100D	0.08
SKCM	chr17	16057520	Missense_Mutation	rs749125122	R2129K	0.45
SKCM	chr17	16101377	Missense_Mutation	NA	P855S	0.39
SKCM	chr17	16068006	Silent	NA	S1543S	0.16
SKCM	chr17	16061822	Silent	NA	A1820A	0.37
SKCM	chr17	16121141	Missense_Mutation	NA	S588F	0.09
SKCM	chr17	16070338	Missense_Mutation	rs375150524	R1447Q	0.39
SKCM	chr17	16061556	Missense_Mutation	NA	P1909L	0.12
SKCM	chr17	16070303	Missense_Mutation	NA	L1459F	0.29
SKCM	chr17	16064971	Missense_Mutation	NA	P1667L	0.15
SKCM	chr17	16057700	Missense_Mutation	NA	S2069F	0.19
SKCM	chr17	16057583	Missense_Mutation	NA	Q2108R	0.13
SKCM	chr17	16151992	Frame_Shift_Ins	novel	*Y266Kfs8**	0.05
SKCM	chr17	16151993	Silent	novel	L265L	0.04
SKCM	chr17	16092046	Missense_Mutation	NA	P945S	0.2
SKCM	chr17	16171897	Missense_Mutation	novel	V114D	0.56
SKCM	chr17	16046990	Missense_Mutation	rs763924640	R2214C	0.68
SKCM	chr17	16039447	Missense_Mutation	NA	P2314L	0.16
SKCM	chr17	16146470	Missense_Mutation	novel	R330W	0.16
SKCM	chr17	16101645	Silent	novel	P765P	0.18
SKCM	chr17	16165038	Missense_Mutation	rs778810900	R187C	0.14
SKCM	chr17	16137360	Frame_Shift_Del	novel	T481*	0.32
SKCM	chr17	16171970	Missense_Mutation	novel	E90K	0.49
SKCM	chr17	16194505	Missense_Mutation	NA	P22L	0.28
SKCM	chr17	16057700	Missense_Mutation	NA	S2069F	0.55
SKCM	chr17	16039627	Missense_Mutation	rs768282882	F2254S	0.42
SKCM	chr17	16058096	Intron	novel		0.32
SKCM	chr17	16092033	Missense_Mutation	NA	P949L	0.07
SKCM	chr17	16075647	Missense_Mutation	novel	S1186F	0.48
SKCM	chr17	16091963	Silent	novel	L972L	0.26
SKCM	chr17	16186600	Nonsense_Mutation	NA	R66*	0.44
SKCM	chr17	16071489	Missense_Mutation	NA	D1358H	0.19
SKCM	chr17	16149495	Missense_Mutation	NA	L289F	0.19
SKCM	chr17	16091841	Intron	NA		0.32
SKCM	chr17	16165130	Missense_Mutation	NA	P156L	0.51
SKCM	chr17	16086404	Missense_Mutation	NA	P1019S	0.08
SKCM	chr17	16121198	Missense_Mutation	NA	P569L	0.38
SKCM	chr17	16171880	Nonsense_Mutation	NA	Q120*	0.3
SKCM	chr17	16086346	Missense_Mutation	NA	P1038L	0.39
SKCM	chr17	16158851	Missense_Mutation	NA	A214V	0.81
SKCM	chr17	16101326	Frame_Shift_Ins	novel	*E872Lfs46**	0.34
SKCM	chr17	16061749	Nonsense_Mutation	NA	E1845*	0.22
SKCM	chr17	16080358	Intron	novel		0.13
SKCM	chr17	16080036	Silent	NA	S1143S	0.63
SKCM	chr17	16061796	Missense_Mutation	novel	A1829V	0.76
SKCM	chr17	16064091	Missense_Mutation	NA	S1733F	0.39
STAD	chr17	16119423	Frame_Shift_Ins	novel	*G639Rfs8**	0.32
STAD	chr17	16101495	Silent	rs139942816	P815P	0.45
STAD	chr17	16032427	Missense_Mutation	NA	P2398S	0.24
STAD	chr17	16101645	Silent	NA	P765P	0.54
STAD	chr17	16108797	Missense_Mutation	NA	E724V	0.35
STAD	chr17	16039443	Silent	NA	S2315S	0.24
STAD	chr17	16068074	Silent	NA	L1521L	0.16
STAD	chr17	16165114	Silent	NA	S161S	0.15
STAD	chr17	16101494	Missense_Mutation	rs76080188	A816T	0.37
STAD	chr17	16086428	Missense_Mutation	NA	P1011S	0.38
STAD	chr17	16068126	Splice_Region	novel		0.44
STAD	chr17	16068042	Silent	rs771741474	A1531A	0.42
STAD	chr17	16138164	Silent	NA	E467E	0.22
STAD	chr17	16137373	Nonsense_Mutation	novel	K483*	0.27
STAD	chr17	16137374	Missense_Mutation	novel	K482N	0.27
STAD	chr17	16057964	Silent	novel	E2037E	0.36
STAD	chr17	16065504	Silent	novel	L1644L	0.34
STAD	chr17	16080471	Nonsense_Mutation	NA	R1113*	0.36
STAD	chr17	16119435	Missense_Mutation	NA	V635I	0.07
STAD	chr17	16121131	Silent	rs761000533	N591N	0.06
STAD	chr17	16032311	Silent	novel	S2436S	0.36
STAD	chr17	16091971	Missense_Mutation	novel	S970P	0.18
STAD	chr17	16171927	Missense_Mutation	NA	L104P	0.23
STAD	chr17	16138184	Missense_Mutation	NA	L461I	0.17
STAD	chr17	16121099	Missense_Mutation	rs749634427	A602V	0.3
STAD	chr17	16138181	Missense_Mutation	novel	I462V	0.39
STAD	chr17	16061889	Missense_Mutation	NA	L1798Q	0.12
STAD	chr17	16071438	Silent	novel	R1375R	0.24
STAD	chr17	16164872	Intron	novel		0.8
STAD	chr17	16067968	Missense_Mutation	NA	A1556V	0.47
STAD	chr17	16070426	Missense_Mutation	novel	P1418S	0.18
STAD	chr17	16046911	Intron	novel		0.29
STAD	chr17	16121190	Nonsense_Mutation	NA	R572*	0.32
STAD	chr17	16121098	Silent	rs778137445	A602A	0.25
STAD	chr17	16067939	Frame_Shift_Ins	novel	*T1566Hfs51**	0.27
STAD	chr17	16121136	Missense_Mutation	NA	T590A	0.05
STAD	chr17	16068012	Silent	rs369446328	V1541V	0.27
STAD	chr17	16072200	Frame_Shift_Del	novel	*S1281Vfs16**	0.3
STAD	chr17	16101269	In_Frame_Del	novel	V889_D890del	0.25
STAD	chr17	16098441	Missense_Mutation	rs781456795	V916I	0.2
STAD	chr17	16146374	Splice_Site	NA	X361_splice	0.14
STAD	chr17	16070193	Silent	NA	G1495G	0.29
STAD	chr17	16086360	Silent	rs747290065	P1033P	0.21
STAD	chr17	16061799	Missense_Mutation	NA	A1828V	0.32
STAD	chr17	16139122	Missense_Mutation	NA	R413K	0.36
STAD	chr17	16121153	Missense_Mutation	NA	R584Q	0.39
STAD	chr17	16064130	Missense_Mutation	rs759534850	R1720Q	0.29
STAD	chr17	16058532	Silent	NA	A1983A	0.25
STAD	chr17	16065623	Missense_Mutation	rs762318164	A1605T	0.15
STAD	chr17	16071441	Missense_Mutation	NA	T1374A	0.18
TGCT	chr17	16070341	Missense_Mutation	novel	S1446F	0.35
THCA	chr17	16080060	Silent	rs752964070	T1135T	0.49
THCA	chr17	16092014	Silent	rs375288132	S955S	0.09
THCA	chr17	16146455	Nonsense_Mutation	novel	*E335Kfs4**	0.09
THCA	chr17	16070496	Silent	NA	S1394S	0.26
UCEC	chr17	16098394	Silent	NA	Q931Q	0.41
UCEC	chr17	16046997	Missense_Mutation	NA	E2211D	0.24
UCEC	chr17	16068156	Intron	novel		0.41
UCEC	chr17	16040469	Silent	rs777246963	I2235I	0.26
UCEC	chr17	16046990	Missense_Mutation	rs763924640	R2214C	0.33
UCEC	chr17	16062111	Missense_Mutation	NA	R1794Q	0.32
UCEC	chr17	16171930	Missense_Mutation	novel	S103L	0.17
UCEC	chr17	16186553	Splice_Site	novel	X81_splice	0.27
UCEC	chr17	16073549	Missense_Mutation	novel	G1231R	0.26
UCEC	chr17	16068229	Intron	novel		0.44
UCEC	chr17	16073554	Missense_Mutation	rs139458532	R1229Q	0.35
UCEC	chr17	16032366	Missense_Mutation	novel	R2418M	0.29
UCEC	chr17	16047062	Missense_Mutation	novel	Y2190H	0.32
UCEC	chr17	16070345	Missense_Mutation	rs183518783	R1445C	0.45
UCEC	chr17	16126142	Frame_Shift_Ins	NA	*T525Nfs11**	0.47
UCEC	chr17	16067974	Missense_Mutation	novel	S1554I	0.14
UCEC	chr17	16057565	Missense_Mutation	novel	R2114T	0.49
UCEC	chr17	16121195	Missense_Mutation	novel	R570Q	0.31
UCEC	chr17	16080361	Intron	novel		0.25
UCEC	chr17	16034860	Missense_Mutation	rs779636265	T2347M	0.38
UCEC	chr17	16057609	Silent	novel	N2099N	0.59
UCEC	chr17	16080706	Missense_Mutation	novel	T1067P	0.42
UCEC	chr17	16101295	Missense_Mutation	novel	T882M	0.45
UCEC	chr17	16032348	Missense_Mutation	novel	P2424H	0.08
UCEC	chr17	16146508	Missense_Mutation	novel	A317V	0.27
UCEC	chr17	16186607	Missense_Mutation	novel	Q63H	0.42
UCEC	chr17	16032398	Silent	rs571237971	A2407A	0.47
UCEC	chr17	16064136	Missense_Mutation	rs369094623	R1718Q	0.35
UCEC	chr17	16068028	Missense_Mutation	novel	P1536L	0.4
UCEC	chr17	16126140	Missense_Mutation	novel	E526K	0.34
UCEC	chr17	16080361	Intron	novel		0.19
UCEC	chr17	16146385	Missense_Mutation	novel	R358I	0.33
UCEC	chr17	16091836	Intron	novel		0.06
UCEC	chr17	16165115	Missense_Mutation	rs765365064	S161L	0.11
UCEC	chr17	16032355	Nonsense_Mutation	NA	R2422*	0.21
UCEC	chr17	16048882	Missense_Mutation	NA	L2167I	0.1
UCEC	chr17	16071629	Missense_Mutation	NA	G1311D	0.23
UCEC	chr17	16101288	Silent	rs764199874	S884S	0.25
UCEC	chr17	16073437	Missense_Mutation	NA	P1268L	0.46
UCEC	chr17	16048914	Missense_Mutation	rs773322630	P2156L	0.24
UCEC	chr17	16062242	Frame_Shift_Ins	novel	*H1751Ffs12**	0.07
UCEC	chr17	16108832	Silent	novel	E712E	0.2
UCEC	chr17	16071582	Missense_Mutation	novel	A1327T	0.36
UCEC	chr17	16065490	Missense_Mutation	rs746822331	T1649M	0.43
UCEC	chr17	16068079	Missense_Mutation	rs759642635	S1519L	0.53
UCEC	chr17	16061669	Silent	novel	L1871L	0.24
UCEC	chr17	16067997	Silent	novel	P1546P	0.32
UCEC	chr17	16075652	Missense_Mutation	novel	K1184N	0.26
UCEC	chr17	16062228	Missense_Mutation	NA	R1755H	0.44
UCEC	chr17	16061441	Silent	rs768312099	A1947A	0.42
UCEC	chr17	16080483	Nonsense_Mutation	NA	E1109*	0.1
UCEC	chr17	16061453	Silent	rs761830574	S1943S	0.09
UCEC	chr17	16048972	Missense_Mutation	novel	P2137T	0.28
UCEC	chr17	16070331	Silent	rs370804623	T1449T	0.39
UCEC	chr17	16101594	Silent	novel	T782T	0.47
UCEC	chr17	16040448	Silent	novel	T2242T	0.21
UCEC	chr17	16091849	Intron	novel		0.18
UCEC	chr17	16068092	Missense_Mutation	novel	H1515Y	0.12
UCEC	chr17	16121245	Missense_Mutation	novel	K553N	0.12
UCEC	chr17	16137365	Missense_Mutation	novel	E485D	0.54
UCEC	chr17	16057552	Silent	novel	R2118R	0.4
UCEC	chr17	16071487	Silent	novel	D1358D	0.44
UCEC	chr17	16143642	Silent	novel	E379E	0.38
UCEC	chr17	16151945	Splice_Site	novel	X281_splice	0.32
UCEC	chr17	16186665	Missense_Mutation	rs747285406	R44H	0.42
UCEC	chr17	16086376	Missense_Mutation	novel	R1028Q	0.1
UCEC	chr17	16098389	Missense_Mutation	novel	R933Q	0.46
UCEC	chr17	16101800	Intron	novel		0.41
UCEC	chr17	16146416	Nonsense_Mutation	novel	E348*	0.23
UCEC	chr17	16067982	Silent	novel	H1551H	0.46
UCEC	chr17	16126200	Missense_Mutation	novel	A506T	0.51
UCEC	chr17	16034859	Silent	rs747092561	T2347T	0.3
UCEC	chr17	16057608	Missense_Mutation	rs372647037	R2100C	0.11
UCEC	chr17	16065580	Missense_Mutation	NA	T1619I	0.35
UCEC	chr17	16070310	Silent	novel	P1456P	0.11
UCEC	chr17	16186599	Missense_Mutation	NA	R66Q	0.52
UCEC	chr17	16032371	Missense_Mutation	novel	Q2416H	0.3
UCEC	chr17	16061482	Missense_Mutation	novel	D1934N	0.31
UCEC	chr17	16101782	Intron	novel		0.27
UCEC	chr17	16139134	Missense_Mutation	novel	D409G	0.39
UCEC	chr17	16149497	Missense_Mutation	novel	K288T	0.29
UCEC	chr17	16046947	Splice_Region	novel		0.46
UCEC	chr17	16101700	Missense_Mutation	novel	T747I	0.25
UCEC	chr17	16068126	Splice_Region	novel		0.38
UCEC	chr17	16080630	Missense_Mutation	NA	R1092Q	0.51
UCEC	chr17	16048950	Missense_Mutation	rs779213445	S2144L	0.1
UCEC	chr17	16062229	Missense_Mutation	NA	R1755C	0.22
UCEC	chr17	16080695	Missense_Mutation	novel	N1070K	0.44
UCEC	chr17	16117929	Nonsense_Mutation	NA	R672*	0.44
UCEC	chr17	16146470	Missense_Mutation	novel	R330W	0.39
UCEC	chr17	16062111	Missense_Mutation	NA	R1794Q	0.22
UCEC	chr17	16032361	Missense_Mutation	novel	W2420R	0.36
UCEC	chr17	16058324	Intron	novel		0.29
UCEC	chr17	16091905	Missense_Mutation	novel	S992R	0.35
UCEC	chr17	16071424	Missense_Mutation	novel	E1379D	0.06
UCEC	chr17	16080060	Silent	rs752964070	T1135T	0.35
UCEC	chr17	16064131	Missense_Mutation	novel	R1720W	0.46
UCEC	chr17	16067936	Missense_Mutation	novel	H1567D	0.37
UCEC	chr17	16108810	Nonsense_Mutation	novel	E720*	0.33
UCEC	chr17	16171932	Missense_Mutation	novel	D102E	0.07
UCEC	chr17	16126142	Frame_Shift_Ins	NA	*T525Nfs11**	0.47
UCEC	chr17	16075547	Silent	NA	I1219I	0.32
UCEC	chr17	16146409	Missense_Mutation	NA	R350Q	0.05
UCEC	chr17	16126142	Frame_Shift_Ins	NA	*T525Nfs11**	0.4
UCEC	chr17	16070516	Missense_Mutation	rs756157847	I1388V	0.09
UCEC	chr17	16098495	Missense_Mutation	novel	M898L	0.15
UCEC	chr17	16171981	Missense_Mutation	novel	R86I	0.17
UCEC	chr17	16067936	Missense_Mutation	novel	H1567Y	0.29
UCEC	chr17	16080053	Missense_Mutation	novel	A1138S	0.28
UCEC	chr17	16101371	Missense_Mutation	rs764558300	D857Y	0.2
UCEC	chr17	16139022	Missense_Mutation	novel	E446D	0.48
UCEC	chr17	16171967	Missense_Mutation	novel	P91S	0.33
UCEC	chr17	16098380	Missense_Mutation	novel	V936A	0.42
UCEC	chr17	16171992	Silent	novel	P82P	0.33
UCEC	chr17	16048885	Silent	novel	L2166L	0.06
UCEC	chr17	16062228	Missense_Mutation	NA	R1755H	0.1
UCEC	chr17	16068035	Missense_Mutation	NA	P1534S	0.36
UCEC	chr17	16086360	Silent	rs747290065	P1033P	0.33
UCEC	chr17	16186594	Nonsense_Mutation	novel	R68*	0.04
UCEC	chr17	16126083	Missense_Mutation	novel	K545E	0.37
UCEC	chr17	16061434	Missense_Mutation	novel	R1950C	0.04
UCEC	chr17	16064137	Missense_Mutation	rs373216507	R1718W	0.38
UCEC	chr17	16068068	Missense_Mutation	novel	P1523T	0.06
UCEC	chr17	16119442	Silent	novel	E632E	0.18
UCEC	chr17	16121173	Missense_Mutation	novel	S577R	0.09
UCEC	chr17	16071631	Silent	rs772888503	D1310D	0.21
UCEC	chr17	16061773	Missense_Mutation	NA	S1837P	0.21
UCEC	chr17	16070234	Missense_Mutation	NA	R1482W	0.05
UCEC	chr17	16046919	Intron	novel		0.37
UCEC	chr17	16034896	Missense_Mutation	NA	S2335Y	0.4
UCEC	chr17	16149473	Missense_Mutation	NA	R296I	0.46
UCEC	chr17	16119424	Frame_Shift_Del	novel	*G639Vfs2**	0.55
UCEC	chr17	16151960	Silent	novel	H276H	0.37
UCEC	chr17	16065690	Silent	rs780188590	A1582A	0.41
UCEC	chr17	16146469	Missense_Mutation	novel	R330Q	0.34
UCEC	chr17	16070242	Missense_Mutation	NA	T1479I	0.19
UCEC	chr17	16058324	Intron	novel		0.3
UCEC	chr17	16071525	Nonsense_Mutation	NA	E1346*	0.35
UCEC	chr17	16194536	Missense_Mutation	NA	A12T	0.3
UCEC	chr17	16032316	Missense_Mutation	novel	L2435M	0.29
UCEC	chr17	16039466	Nonsense_Mutation	novel	R2308*	0.21
UCEC	chr17	16040446	Missense_Mutation	rs571174228	T2243M	0.19
UCEC	chr17	16065601	Missense_Mutation	novel	T1612I	0.17
UCEC	chr17	16086354	Silent	rs183687311	P1035P	0.22
UCEC	chr17	16086440	Missense_Mutation	novel	L1007I	0.46
UCEC	chr17	16171825	Missense_Mutation	novel	R138M	0.24
UCEC	chr17	16032447	Missense_Mutation	NA	R2391Q	0.41
UCEC	chr17	16194609	5'UTR	novel		0.42
UCEC	chr17	16070490	Silent	novel	Q1396Q	0.35
UCEC	chr17	16126132	Frame_Shift_Del	NA	*E529Kfs26**	0.43
UCEC	chr17	16164976	Splice_Region	novel		0.46
UCEC	chr17	16032256	3'UTR	novel		0.1
UCEC	chr17	16057687	Silent	novel	P2073P	0.47
UCEC	chr17	16143691	Missense_Mutation	novel	G363V	0.35
UCEC	chr17	16061706	Missense_Mutation	novel	A1859V	0.43
UCEC	chr17	16062111	Missense_Mutation	NA	R1794Q	0.29
UCEC	chr17	16064098	Missense_Mutation	novel	A1731T	0.3
UCEC	chr17	16067965	Missense_Mutation	novel	G1557D	0.39
UCEC	chr17	16139080	Missense_Mutation	novel	P427L	0.3
UCEC	chr17	16143679	Missense_Mutation	novel	A367V	0.29
UCEC	chr17	16171996	Splice_Site	novel	X81_splice	0.32
UCEC	chr17	16194609	5'UTR	novel		0.42

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.1667	0.18166
ESCA	DEL	0.413	0.074408
LIHC	DEL	0.4865	0.0001026
READ	DEL	0.6545	0.077076
THCA	DEL	0.014	0.221
UCEC	DEL	0.2412	0.00043918
UCS	DEL	0.6964	0.19877

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
ACC	0.038	Kaplan-Meier Survival Analysis
SKCM	0.011	Kaplan-Meier Survival Analysis
PRAD	0.017	Kaplan-Meier Survival Analysis
LUSC	0.031	Kaplan-Meier Survival Analysis
KIRP	0.044	Kaplan-Meier Survival Analysis
READ	0.015	Kaplan-Meier Survival Analysis
KICH	0.028	Kaplan-Meier Survival Analysis
LIHC	0.038	Kaplan-Meier Survival Analysis
DLBC	0.04	Kaplan-Meier Survival Analysis
LGG	0.035	Kaplan-Meier Survival Analysis
UVM	0.05	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000141027 (Gene tree)
Gene ID: 9611
Gene Symbol: NCOR1
Alias: N-CoR|hCIT529I10|TRAC1|hN-CoR|KIAA1047|MGC104216|PPP1R109
Full Name: nuclear receptor corepressor 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 189,029 bases
Position: chr17:16,029,157-16,218,185
Accession: 7672
RBP type: non-canonical RBP
Summary: This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
27107895	KLF17 attenuates estrogen receptor α-mediated signaling by impeding ERα function on chromatin and determines response to endocrine therapy.	Biochim Biophys Acta	2016 Jul	Ali A	doi: 10.1016/j.bbagrm.2016.04.009

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000395851	NCOR1-204	7950	XM_011524085	ENSP00000379192	2337 (aa)	XP_011522387	O75376
ENST00000458113	NCOR1-210	3490	-	-	- (aa)	-	-
ENST00000395857	NCOR1-205	9501	-	ENSP00000379198	2343 (aa)	-	A0A088AWL3
ENST00000411510	NCOR1-206	1883	-	ENSP00000407998	545 (aa)	-	E7EW50
ENST00000582357	NCOR1-221	1877	-	ENSP00000462308	546 (aa)	-	J3KS51
ENST00000430577	NCOR1-207	1204	-	ENSP00000410784	125 (aa)	-	C9JAP0
ENST00000585296	NCOR1-226	983	-	-	- (aa)	-	-
ENST00000583234	NCOR1-224	755	-	-	- (aa)	-	-
ENST00000579974	NCOR1-218	406	-	-	- (aa)	-	-
ENST00000582565	NCOR1-222	672	-	-	- (aa)	-	-
ENST00000580554	NCOR1-219	650	-	ENSP00000463169	217 (aa)	-	J3QKP0
ENST00000464381	NCOR1-212	2474	-	-	- (aa)	-	-
ENST00000466825	NCOR1-213	589	-	-	- (aa)	-	-
ENST00000603989	NCOR1-227	247	-	ENSP00000474008	57 (aa)	-	S4R380
ENST00000579606	NCOR1-217	551	-	ENSP00000462281	184 (aa)	-	J3KS29
ENST00000584872	NCOR1-225	865	-	-	- (aa)	-	-
ENST00000268712	NCOR1-201	10720	XM_005256866	ENSP00000268712	2440 (aa)	XP_005256923	O75376
ENST00000472189	NCOR1-215	793	-	-	- (aa)	-	-
ENST00000395848	NCOR1-202	3106	-	ENSP00000379189	914 (aa)	-	O75376
ENST00000395849	NCOR1-203	3419	-	ENSP00000379190	1071 (aa)	-	E7EVK1
ENST00000436828	NCOR1-209	1969	-	ENSP00000387727	537 (aa)	-	E7EVU5
ENST00000580617	NCOR1-220	1352	-	-	- (aa)	-	-
ENST00000583226	NCOR1-223	614	-	-	- (aa)	-	-
ENST00000436068	NCOR1-208	274	-	ENSP00000389839	92 (aa)	-	H0Y459
ENST00000460276	NCOR1-211	1848	-	ENSP00000462794	88 (aa)	-	J3KT44
ENST00000579573	NCOR1-216	549	-	ENSP00000461959	183 (aa)	-	J3KRE4
ENST00000470782	NCOR1-214	3987	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000141027's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa01522	Endocrine resistance	KEGG
hsa04919	Thyroid hormone signaling pathway	KEGG
hsa05202	Transcriptional misregulation in cancer	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000141027	Platelet Function Tests	2.0338100E-005	-
ENSG00000141027	Platelet Function Tests	1.3508700E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000141027	rs1075901	17	16040596	?	Body mass index	30595370			EFO_0004340
ENSG00000141027	rs11078333	17	16146312	A	Free thyroxine concentration	30367059	[0.03-0.054] unit increase	0.042	EFO_0005130
ENSG00000141027	rs34351630	17	16127206	T	Lung function (FVC)	30804560	[0.01-0.019] unit increase	0.0147	EFO_0004312
ENSG00000141027	rs34351630	17	16127206	T	FEV1	30804560	[0.009-0.018] unit increase	0.0135	EFO_0004314
ENSG00000141027	rs178810	17	16194116	T	C-reactive protein levels	30388399	[0.012-0.028] unit increase	0.02	EFO_0004458

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000141027's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000118	histone deacetylase complex	21873635.	IBA	Component
GO:0000118	histone deacetylase complex	18326024.	IDA	Component
GO:0000122	negative regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0000122	negative regulation of transcription by RNA polymerase II	12628926.18052923.19955185.20388878.	IMP	Process
GO:0000122	negative regulation of transcription by RNA polymerase II	-	TAS	Process
GO:0000790	nuclear chromatin	21873635.	IBA	Component
GO:0000790	nuclear chromatin	17505061.20388878.	IDA	Component
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0001012	RNA polymerase II regulatory region DNA binding	21873635.	IBA	Function
GO:0001102	RNA polymerase II activating transcription factor binding	19955185.	IPI	Function
GO:0003682	chromatin binding	21873635.	IBA	Function
GO:0003714	transcription corepressor activity	21873635.	IBA	Function
GO:0003714	transcription corepressor activity	18052923.	IDA	Function
GO:0003714	transcription corepressor activity	12628926.15695367.20812024.	IMP	Function
GO:0005515	protein binding	10049357.11013263.11486045.11931768.12628926.14525983.16606617.16980585.17500595.17519354.17572682.18952841.19032343.19955185.20543827.20581824.20812024.21258344.21775429.21988832.23752268.25303530.26120082.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	18052923.	IC	Component
GO:0005634	nucleus	10049357.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006325	chromatin organization	-	IEA	Process
GO:0006366	transcription by RNA polymerase II	7566114.	TAS	Process
GO:0007623	circadian rhythm	-	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016580	Sin3 complex	21873635.	IBA	Component
GO:0016580	Sin3 complex	11486045.	IDA	Component
GO:0017053	transcriptional repressor complex	21873635.	IBA	Component
GO:0017053	transcriptional repressor complex	11804585.12628926.	IDA	Component
GO:0019216	regulation of lipid metabolic process	-	TAS	Process
GO:0035257	nuclear hormone receptor binding	21873635.	IBA	Function
GO:0035257	nuclear hormone receptor binding	9328355.	IPI	Function
GO:0042826	histone deacetylase binding	21873635.	IBA	Function
GO:0042826	histone deacetylase binding	11804585.	IPI	Function
GO:0043565	sequence-specific DNA binding	21873635.	IBA	Function
GO:0044212	transcription regulatory region DNA binding	-	ISS	Function
GO:0045892	negative regulation of transcription, DNA-templated	20812024.	IMP	Process
GO:0046329	negative regulation of JNK cascade	11931768.	IDA	Process
GO:0046966	thyroid hormone receptor binding	21873635.	IBA	Function
GO:0051225	spindle assembly	18326024.	IMP	Process
GO:0060766	negative regulation of androgen receptor signaling pathway	20812024.	IMP	Process
GO:0072362	regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter	19955185.	IMP	Process
GO:0072368	regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter	19955185.	IMP	Process
GO:0072686	mitotic spindle	18326024.	IDA	Component
GO:1903799	negative regulation of production of miRNAs involved in gene silencing by miRNA	20388878.	IMP	Process
GO:2000191	regulation of fatty acid transport	19955185.	IC	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.