EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28350096	CIRH1A augments the proliferation of RKO colorectal cancer cells.	Oncol Rep	2017 Apr	Guo F	doi: 10.3892/or.2017.5497

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr16	69166983	Intron	novel		0.29
BLCA	chr16	69155951	Silent	novel	L415L	0.4
BLCA	chr16	69163086	Missense_Mutation	novel	H519Y	0.22
BLCA	chr16	69165377	Missense_Mutation	NA	D562H	0.15
BLCA	chr16	69165379	Silent	NA	D562D	0.42
BLCA	chr16	69133574	Missense_Mutation	novel	T39A	0.08
BLCA	chr16	69150881	Missense_Mutation	rs774735552	L327V	0.28
BLCA	chr16	69150643	Missense_Mutation	rs781261871	P282L	0.48
BRCA	chr16	69168846	Missense_Mutation	NA	D657A	0.27
BRCA	chr16	69167265	Intron	novel		0.21
BRCA	chr16	69150836	Missense_Mutation	NA	R312C	0.36
BRCA	chr16	69167123	In_Frame_Ins	novel	E629_D631dup	0.19
BRCA	chr16	69157209	Missense_Mutation	NA	F471L	0.19
CESC	chr16	69150567	Missense_Mutation	rs145040987	E257K	0.32
CESC	chr16	69153629	Nonsense_Mutation	novel	Q350*	0.21
CESC	chr16	69167066	Intron	rs747226414		0.41
CESC	chr16	69165472	Silent	rs375859741	P593P	0.28
COAD	chr16	69150613	Missense_Mutation	NA	S272I	0.48
COAD	chr16	69133519	Silent	NA	R20R	0.12
COAD	chr16	69133619	Splice_Site	novel	X53_splice	0.14
COAD	chr16	69154451	Missense_Mutation	novel	K386N	0.19
COAD	chr16	69168821	Missense_Mutation	novel	P649S	0.28
COAD	chr16	69168914	Frame_Shift_Del	NA	*K681Rfs?**	0.39
COAD	chr16	69150536	Splice_Site	novel	X247_splice	0.33
COAD	chr16	69157138	Missense_Mutation	NA	D448N	0.3
COAD	chr16	69153584	Nonsense_Mutation	novel	R335*	0.11
COAD	chr16	69150569	Silent	novel	E257E	0.17
COAD	chr16	69167078	Missense_Mutation	novel	L613I	0.15
COAD	chr16	69155943	Frame_Shift_Del	novel	*L415Sfs4**	0.43
COAD	chr16	69165471	Missense_Mutation	rs769413821	P593L	0.21
COAD	chr16	69150551	Silent	rs767259669	F251F	0.3
COAD	chr16	69157176	Silent	novel	A460A	0.06
COAD	chr16	69165449	Missense_Mutation	NA	I586V	0.19
COAD	chr16	69157087	Missense_Mutation	novel	S431P	0.44
COAD	chr16	69133571	Missense_Mutation	NA	G38C	0.14
COAD	chr16	69165429	Missense_Mutation	novel	R579M	0.24
ESCA	chr16	69166257	Intron	novel		0.55
ESCA	chr16	69166258	Intron	novel		0.58
ESCA	chr16	69139881	Frame_Shift_Ins	novel	*D166Rfs4**	0.24
ESCA	chr16	69160376	Missense_Mutation	novel	L489V	0.25
ESCA	chr16	69167218	Intron	novel		0.39
GBM	chr16	69155933	Silent	novel	T409T	0.18
GBM	chr16	69167148	Missense_Mutation	rs34057086	R636H	0.42
GBM	chr16	69169028	3'Flank	novel		0.51
GBM	chr16	69168944	3'UTR	novel		0.04
HNSC	chr16	69150547	Missense_Mutation	novel	S250I	0.83
HNSC	chr16	69165553	Intron	novel		0.37
KIRC	chr16	69165385	Silent	NA	S564S	0.36
KIRC	chr16	69167036	Intron	novel		0.31
KIRC	chr16	69165438	Missense_Mutation	NA	P582R	0.17
KIRP	chr16	69136795	Missense_Mutation	novel	D87N	0.38
LGG	chr16	69165470	Missense_Mutation	NA	P593A	0.22
LGG	chr16	69150885	Missense_Mutation	rs762272300	R328Q	0.42
LUAD	chr16	69150695	Silent	rs554532839	A299A	0.19
LUAD	chr16	69150588	Missense_Mutation	NA	Q264K	0.62
LUAD	chr16	69155941	Missense_Mutation	novel	R412L	0.13
LUSC	chr16	69136708	Missense_Mutation	NA	H58D	0.05
LUSC	chr16	69168852	Missense_Mutation	NA	R659K	0.3
LUSC	chr16	69165463	Silent	novel	P590P	0.69
LUSC	chr16	69168884	Missense_Mutation	NA	D670N	0.36
LUSC	chr16	69165377	Missense_Mutation	rs781456221	D562Y	0.15
MESO	chr16	69165345	Missense_Mutation	novel	F551S	0.4
OV	chr16	69136773	Silent	novel	L79L	0.06
OV	chr16	69143325	In_Frame_Ins	novel	T225_G226insKGVSVLI	0.1
OV	chr16	69168956	3'UTR	novel		0.44
OV	chr16	69165476	Frame_Shift_Ins	novel	*H595Lfs6**	0.04
OV	chr16	69168979	3'UTR	novel		0.85
PAAD	chr16	69163160	Silent	rs554592005	I543I	0.09
PAAD	chr16	69165516	Missense_Mutation	novel	D608A	0.19
PRAD	chr16	69143338	Silent	novel	V229V	0.2
PRAD	chr16	69160402	Silent	novel	N497N	0.12
PRAD	chr16	69136779	Silent	novel	G81G	0.41
READ	chr16	69139827	Missense_Mutation	NA	R147C	0.31
READ	chr16	69165505	Missense_Mutation	novel	F604L	0.36
READ	chr16	69168860	Missense_Mutation	novel	V662M	0.63
SARC	chr16	69166027	Intron	novel		0.26
SKCM	chr16	69136758	Silent	novel	L74L	0.2
SKCM	chr16	69167188	Splice_Region	novel		0.3
SKCM	chr16	69167321	Intron	novel		0.57
SKCM	chr16	69150883	Silent	novel	L327L	0.31
SKCM	chr16	69150899	Missense_Mutation	NA	P333S	0.24
SKCM	chr16	69167223	Intron	novel		0.17
SKCM	chr16	69150887	Nonsense_Mutation	NA	K329*	0.32
SKCM	chr16	69168958	3'UTR	novel		0.45
SKCM	chr16	69143265	Missense_Mutation	rs754799561	S205F	0.37
SKCM	chr16	69150542	Silent	novel	E248E	0.29
SKCM	chr16	69163113	Missense_Mutation	NA	P528S	0.54
SKCM	chr16	69143242	Silent	rs149282985	I197I	0.09
STAD	chr16	69167066	Intron	rs747226414		0.46
STAD	chr16	69167142	Missense_Mutation	rs139624123	R634Q	0.24
STAD	chr16	69133573	Silent	novel	G38G	0.3
STAD	chr16	69167128	Silent	NA	E629E	0.14
STAD	chr16	69167066	Intron	rs747226414		0.25
STAD	chr16	69137874	Missense_Mutation	NA	D142G	0.43
STAD	chr16	69150885	Missense_Mutation	rs762272300	R328Q	0.34
STAD	chr16	69150633	Missense_Mutation	NA	R279W	0.16
TGCT	chr16	69143372	Missense_Mutation	novel	S241T	0.11
THCA	chr16	69167091	Missense_Mutation	rs765477757	K617R	0.44
THCA	chr16	69136884	Frame_Shift_Ins	novel	*L117Tfs12**	0.02
UCEC	chr16	69136805	Missense_Mutation	rs755772687	A90V	0.49
UCEC	chr16	69143241	Missense_Mutation	NA	I197T	0.13
UCEC	chr16	69168968	3'UTR	novel		0.27
UCEC	chr16	69155938	Missense_Mutation	novel	S411Y	0.4
UCEC	chr16	69167170	Missense_Mutation	novel	I643M	0.37
UCEC	chr16	69157108	Missense_Mutation	rs376717692	R438C	0.43
UCEC	chr16	69166880	Intron	novel		0.45
UCEC	chr16	69143242	Silent	rs149282985	I197I	0.43
UCEC	chr16	69150837	Missense_Mutation	NA	R312H	0.35
UCEC	chr16	69165400	Silent	novel	K569K	0.48
UCEC	chr16	69167256	Intron	novel		0.2
UCEC	chr16	69168849	Missense_Mutation	novel	E658A	0.1
UCEC	chr16	69167066	Intron	rs747226414		0.46
UCEC	chr16	69155894	Missense_Mutation	novel	S396R	0.38
UCEC	chr16	69166943	Intron	novel		0.38
UCEC	chr16	69155942	Silent	rs754208879	R412R	0.26
UCEC	chr16	69150669	Missense_Mutation	rs773025409	R291C	0.13
UCEC	chr16	69165471	Missense_Mutation	rs769413821	P593L	0.14
UCEC	chr16	69167459	Intron	novel		0.31
UCEC	chr16	69136778	Missense_Mutation	NA	G81D	0.22
UCEC	chr16	69150687	Missense_Mutation	NA	P297T	0.29
UCEC	chr16	69167272	Intron	rs563869928		0.19
UCEC	chr16	69150871	Silent	rs148894405	Y323Y	0.4
UCEC	chr16	69153584	Nonsense_Mutation	novel	R335*	0.05
UCEC	chr16	69166880	Intron	novel		0.27
UCEC	chr16	69165580	Intron	novel		0.38
UCEC	chr16	69167069	Splice_Region	novel		0.25
UCEC	chr16	69154434	Missense_Mutation	novel	H381N	0.28
UCEC	chr16	69136752	Silent	rs773337143	Q72Q	0.26
UCEC	chr16	69150878	Missense_Mutation	rs763509506	A326T	0.28
UCEC	chr16	69166027	Intron	novel		0.41
UCEC	chr16	69166880	Intron	novel		0.44
UCEC	chr16	69157219	Missense_Mutation	novel	H475Y	0.35
UCEC	chr16	69137867	Nonsense_Mutation	novel	F141*	0.03
UCEC	chr16	69166886	Intron	rs191662319		0.48
UCEC	chr16	69166880	Intron	novel		0.31
UCEC	chr16	69136805	Missense_Mutation	rs755772687	A90V	0.38
UCEC	chr16	69167179	Silent	novel	I646I	0.47
UCEC	chr16	69166117	Intron	novel		0.29
UCEC	chr16	69166154	Intron	novel		0.37
UCEC	chr16	69167196	Intron	novel		0.16
UCEC	chr16	69169017	3'UTR	novel		0.27
UCEC	chr16	69150665	Silent	rs771955667	D289D	0.43
UCEC	chr16	69167459	Intron	novel		0.27
UCEC	chr16	69143182	Silent	rs370682701	S177S	0.23
UCEC	chr16	69153662	Nonsense_Mutation	novel	G361*	0.38
UCEC	chr16	69166880	Intron	novel		0.7
UCEC	chr16	69133544	Missense_Mutation	novel	N29H	0.44
UCEC	chr16	69165972	Intron	novel		0.2
UCEC	chr16	69167459	Intron	novel		0.15
UCEC	chr16	69163094	Silent	novel	T521T	0.46
UCEC	chr16	69166880	Intron	novel		0.5
UCEC	chr16	69160448	Missense_Mutation	rs751461578	V513I	0.41
UCEC	chr16	69143354	Missense_Mutation	rs770418250	A235T	0.19
UCEC	chr16	69155955	Missense_Mutation	rs772154514	R417W	0.41
UCEC	chr16	69163153	Missense_Mutation	novel	L541P	0.48
UCEC	chr16	69137867	Missense_Mutation	novel	N140H	0.4
UCEC	chr16	69169016	3'UTR	novel		0.38

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	AMP	0.1961	0.063591
CHOL	DEL	0.1667	0.23475
LAML	DEL	0.0262	0.0010312
TGCT	AMP	0.1133	0.035574
UCEC	DEL	0.2746	4.7164e-05

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00019	Kaplan-Meier Survival Analysis
MESO	0.042	Kaplan-Meier Survival Analysis
ACC	0.047	Kaplan-Meier Survival Analysis
HNSC	0.0012	Kaplan-Meier Survival Analysis
SKCM	0.012	Kaplan-Meier Survival Analysis
PAAD	0.033	Kaplan-Meier Survival Analysis
BLCA	0.0053	Kaplan-Meier Survival Analysis
GBM	0.0034	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
OV	0.027	Kaplan-Meier Survival Analysis

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000141076 (Gene tree)
Gene ID: 84916
Gene Symbol: UTP4
Alias: NAIC|FLJ14728|KIAA1988|TEX292|CIRHIN|CIRH1A
Full Name: UTP4 small subunit processome component
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 99,840 bases
Position: chr16:69,131,291-69,231,130
Accession: 1983
RBP type: non-canonical RBP
Summary: This gene encodes a WD40-repeat-containing protein that is localized to the nucleolus. Mutation of this gene causes North American Indian childhood cirrhosis, a severe intrahepatic cholestasis that results in transient neonatal jaundice, and progresses to periportal fibrosis and cirrhosis in childhood and adolescence. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000567015	UTP4-208	690	-	-	- (aa)	-	-
ENST00000566227	UTP4-207	747	-	ENSP00000462497	198 (aa)	-	J3KSI1
ENST00000563299	UTP4-205	581	-	ENSP00000461517	182 (aa)	-	I3L4T9
ENST00000567460	UTP4-211	595	-	ENSP00000463109	142 (aa)	-	J3KTR0
ENST00000567287	UTP4-210	366	-	-	- (aa)	-	-
ENST00000352319	UTP4-202	1841	-	ENSP00000339164	571 (aa)	-	Q969X6
ENST00000569615	UTP4-215	574	-	-	- (aa)	-	-
ENST00000314423	UTP4-201	2322	XM_005256205	ENSP00000327179	686 (aa)	XP_005256262	Q969X6
ENST00000568448	UTP4-213	562	-	ENSP00000462451	78 (aa)	-	J3KSE6
ENST00000563094	UTP4-204	4183	-	ENSP00000456622	625 (aa)	-	Q969X6
ENST00000569800	UTP4-216	552	-	-	- (aa)	-	-
ENST00000567500	UTP4-212	737	-	ENSP00000456317	211 (aa)	-	H3BRM8
ENST00000564408	UTP4-206	553	-	-	- (aa)	-	-
ENST00000562237	UTP4-203	2186	-	ENSP00000456709	700 (aa)	-	H3BSH7
ENST00000567235	UTP4-209	586	-	ENSP00000455269	148 (aa)	-	H3BPD7
ENST00000569014	UTP4-214	568	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000141076's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03008	Ribosome biogenesis in eukaryotes	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000141076	rs117268208	16	69159416	?	Mean corpuscular hemoglobin	30595370			EFO_0004527

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000141076's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000141076	UTP4	100	97.436	ENSMUSG00000041438	Utp4	100	89.942	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	21873635.	IBA	Process
GO:0001650	fibrillar center	24219289.	IDA	Component
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005515	protein binding	19732766.22916032.24219289.	IPI	Function
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005694	chromosome	20813266.	IDA	Component
GO:0005730	nucleolus	16225863.17699751.	IDA	Component
GO:0006355	regulation of transcription, DNA-templated	19732766.	IDA	Process
GO:0006364	rRNA processing	-	TAS	Process
GO:0030490	maturation of SSU-rRNA	22916032.	IMP	Process
GO:0030686	90S preribosome	21873635.	IBA	Component
GO:0032040	small-subunit processome	21873635.	IBA	Component
GO:0034455	t-UTP complex	21873635.	IBA	Component
GO:0034455	t-UTP complex	22916032.	IDA	Component

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.