EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
18651761	Overexpression of Rho GDP-dissociation inhibitor alpha is associated with tumor progression and poor prognosis of colorectal cancer.	J Proteome Res	2008 Sep	Zhao L	doi: 10.1021/pr800271b
29059157	EphrinB1 promotes cancer cell migration and invasion through the interaction with RhoGDI1.	Oncogene	2018 Feb 15	Cho HJ	doi: 10.1038/onc.2017.386
26416248	RhoGDI deficiency induces constitutive activation of Rho GTPases and COX-2 pathways in association with breast cancer progression.	Oncotarget	2015 Oct 20	Bozza WP	doi: 10.18632/oncotarget.5416.
21569526	Genes associated with prognosis after surgery for malignant pleural mesothelioma promote tumor cell survival in vitro.	BMC Cancer	2011 May 13	Gordon GJ	doi: 10.1186/1471-2407-11-169.
21327297	Targeting S100P inhibits colon cancer growth and metastasis by Lentivirus-mediated RNA interference and proteomic analysis.	Mol Med	2011	Jiang L	doi: 10.2119/molmed.2011.00008
24820414	14-3-3?? promotes breast cancer invasion and metastasis by inhibiting RhoGDIα.	Mol Cell Biol	2014 Jul	Xiao Y	-
23922223	RhoGDIα downregulates androgen receptor signaling in prostate cancer cells.	Prostate	2013 Nov	Zhu Y	doi: 10.1002/pros.22615
21681778	RhoGDIα suppresses growth and survival of prostate cancer cells.	Prostate	2012 Mar	Zhu Y	doi: 10.1002/pros.21441
22668020	Knockdown of RhoGDIα induces apoptosis and increases lung cancer cell chemosensitivity to paclitaxel.	Neoplasma	2012	Rong F	doi: 10.4149/neo_2012_070.
21447808	Loss of Rho GDIα and resistance to tamoxifen via effects on estrogen receptor α.	J Natl Cancer Inst	2011 Apr 6	Barone I	doi: 10.1093/jnci/djr058
22530308	Rho GDP-dissociation inhibitor alpha is associated with cancer metastasis in colon and prostate cancer.	Pharmazie	2012 Mar	Yamashita T	-
20043072	Rho GDP dissociation inhibitor alpha expression correlates with the outcome of CMF treatment in invasive ductal breast cancer.	Int J Oncol	2010 Feb	Ronneburg H	-
22393046	RhoGDI SUMOylation at Lys-138 increases its binding activity to Rho GTPase and its inhibiting cancer cell motility.	J Biol Chem	2012 Apr 20	Yu J	doi: 10.1074/jbc.M111.337469
28417530	Rho GDP-dissociation inhibitor α is a potential prognostic biomarker and controls telomere regulation in colorectal cancer.	Cancer Sci	2017 Jul	Huang D	doi: 10.1111/cas.13259
29307615	Protein phosphatase 1B dephosphorylates Rho guanine nucleotide dissociation inhibitor 1 and suppresses cancer cell migration and invasion.	Cancer Lett	2018 Mar 28	Cho HJ	doi: 10.1016/j.canlet.2018.01.002

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr17	81869784	Silent	novel	R49R	0.95
BLCA	chr17	81868832	3'UTR	novel		0.29
BLCA	chr17	81869229	Missense_Mutation	novel	R120Q	0.48
BLCA	chr17	81868836	3'UTR	novel		0.31
BLCA	chr17	81869023	Silent	rs779427124	Y156Y	0.48
BLCA	chr17	81869934	5'UTR	novel		0.19
BLCA	chr17	81868840	3'UTR	novel		0.33
BRCA	chr17	81868811	3'UTR	rs778903662		0.37
BRCA	chr17	81869551	Missense_Mutation	NA	D89N	0.5
BRCA	chr17	81868952	Missense_Mutation	rs764941554	R180H	0.05
CESC	chr17	81868138	3'UTR	novel		0.21
CESC	chr17	81867841	3'UTR	novel		0.34
CESC	chr17	81868105	3'UTR	novel		0.39
CESC	chr17	81869369	Silent	novel	L104L	0.16
CESC	chr17	81869856	Silent	NA	V25V	0.16
CESC	chr17	81869230	Nonsense_Mutation	rs587777553	R120*	0.57
COAD	chr17	81869037	Missense_Mutation	novel	R152W	0.39
COAD	chr17	81869617	Missense_Mutation	rs200283878	V67I	0.17
COAD	chr17	81868811	3'UTR	rs778903662		0.4
COAD	chr17	81868855	3'UTR	novel		0.35
COAD	chr17	81868811	3'UTR	rs778903662		0.52
COAD	chr17	81868748	3'UTR	rs756985934		0.24
COAD	chr17	81868862	3'UTR	rs754757370		0.38
COAD	chr17	81869344	Missense_Mutation	NA	K113Q	0.28
ESCA	chr17	81868168	3'UTR	rs563695856		0.61
GBM	chr17	81869194	Missense_Mutation	novel	T132A	0.24
GBM	chr17	81868904	Missense_Mutation	NA	L196R	0.81
HNSC	chr17	81869872	Frame_Shift_Ins	novel	*E20Gfs3**	0.32
HNSC	chr17	81868810	3'UTR	rs757131763		0.42
HNSC	chr17	81868939	Missense_Mutation	novel	D184E	0.32
HNSC	chr17	81868851	3'UTR	novel		0.2
KIRC	chr17	81869738	Splice_Region	novel		0.2
KIRP	chr17	81869910	Silent	novel	T7T	0.29
LIHC	chr17	81868960	Missense_Mutation	NA	I177M	0.12
LUAD	chr17	81869844	Silent	novel	P29P	0.16
LUSC	chr17	81869890	Missense_Mutation	novel	I14T	0.36
LUSC	chr17	81869337	Missense_Mutation	rs775688385	S115C	0.12
PAAD	chr17	81869229	Missense_Mutation	novel	R120Q	0.2
PAAD	chr17	81869540	Splice_Site	novel	X92_splice	0.16
PRAD	chr17	81868833	3'UTR	rs202026197		0.6
SARC	chr17	81868573	3'UTR	novel		0.58
SKCM	chr17	81869231	Silent	rs371966890	N119N	0.41
SKCM	chr17	81869217	Missense_Mutation	NA	S124F	0.49
SKCM	chr17	81869892	Silent	NA	Q13Q	0.1
SKCM	chr17	81868912	Silent	novel	E193E	0.14
STAD	chr17	81868845	3'UTR	rs1057283		0.17
STAD	chr17	81868811	3'UTR	rs778903662		0.26
STAD	chr17	81868891	Missense_Mutation	NA	K200N	0.12
STAD	chr17	81868844	3'UTR	novel		0.31
STAD	chr17	81869193	Missense_Mutation	NA	T132M	0.16
STAD	chr17	81869205	Missense_Mutation	novel	Y128C	0.12
UCEC	chr17	81867828	3'UTR	novel		0.36
UCEC	chr17	81869185	Missense_Mutation	novel	K135E	0.09
UCEC	chr17	81869884	Missense_Mutation	novel	A16V	0.43
UCEC	chr17	81869812	Missense_Mutation	novel	E40G	0.05
UCEC	chr17	81869798	Missense_Mutation	NA	D45N	0.21
UCEC	chr17	81867768	3'UTR	novel		0.64
UCEC	chr17	81869038	Silent	novel	P151P	0.28
UCEC	chr17	81869393	Missense_Mutation	novel	S96R	0.21
UCEC	chr17	81869176	Missense_Mutation	NA	K138E	0.48
UCEC	chr17	81867899	3'UTR	novel		0.28
UCEC	chr17	81869014	Silent	rs780341101	L159L	0.22
UCEC	chr17	81868881	Missense_Mutation	novel	D204N	0.31
UCEC	chr17	81868354	3'UTR	novel		0.32
UCEC	chr17	81869744	Missense_Mutation	rs752693120	A63T	0.38
UCEC	chr17	81869193	Missense_Mutation	NA	T132M	0.51
UCEC	chr17	81868283	3'UTR	rs149162567		0.39
UCEC	chr17	81868327	3'UTR	novel		0.38
UCEC	chr17	81869216	Silent	novel	S124S	0.39
UVM	chr17	81869230	Nonsense_Mutation	rs587777553	R120*	0.51

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	AMP	0.3922	0.00012456
CESC	DEL	0.1051	0.00067839
KIRP	AMP	0.6701	0.14801
LGG	AMP	0.0663	1.52e-05
SARC	AMP	0.1984	0.032181
SKCM	AMP	0.2834	7.0388e-08
THCA	DEL	0.002	0.221
UVM	AMP	0.1625	0.054583

Survival Analysis

Cancer	P-value	Q-value
ACC	0.00011	Kaplan-Meier Survival Analysis
UCS	0.027	Kaplan-Meier Survival Analysis
HNSC	0.021	Kaplan-Meier Survival Analysis
SKCM	0.0085	Kaplan-Meier Survival Analysis
LUSC	0.0067	Kaplan-Meier Survival Analysis
BLCA	0.015	Kaplan-Meier Survival Analysis
CESC	0.031	Kaplan-Meier Survival Analysis
LAML	0.034	Kaplan-Meier Survival Analysis
GBM	0.015	Kaplan-Meier Survival Analysis
LIHC	0.02	Kaplan-Meier Survival Analysis
LGG	0.006	Kaplan-Meier Survival Analysis
LUAD	0.029	Kaplan-Meier Survival Analysis
UVM	0.0063	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000141522 (Gene tree)
Gene ID: 396
Gene Symbol: ARHGDIA
Alias: RHOGDI|GDIA1
Full Name: Rho GDP dissociation inhibitor alpha
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 3,688 bases
Position: chr17:81,867,719-81,871,406
Accession: 678
RBP type: non-canonical RBP
Summary: This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the disassociation of Rho family members from GDP (guanine diphosphate), thereby maintaining these factors in an inactive state. Activity of this protein is important in a variety of cellular processes, and expression of this gene may be altered in tumors. Mutations in this gene have been found in individuals with nephrotic syndrome, type 8. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
14583493	Proteomic profiling drug-induced apoptosis in non-small cell lung carcinoma: identification of RS/DJ-1 and RhoGDIalpha.	Cancer Res	2003 Oct 15	MacKeigan JP	-
30973085	Rutin hydrate inhibits apoptosis in the brains of cadmium chloride-treated rats via preserving the mitochondrial integrity and inhibiting endoplasmic reticulum stress.	Neurol Res	2019 Jul	Mostafa DG	doi: 10.1080/01616412.2019.1596206
26761212	Interplay between PCBP2 and miRNA modulates ARHGDIA expression and function in glioma migration and invasion.	Oncotarget	2016 Apr 12	Lin X	doi: 10.18632/oncotarget.6869.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000583791	ARHGDIA-214	351	-	-	- (aa)	-	-
ENST00000580033	ARHGDIA-206	547	-	ENSP00000463530	92 (aa)	-	J3KS60
ENST00000582984	ARHGDIA-211	823	-	-	- (aa)	-	-
ENST00000581876	ARHGDIA-208	709	-	ENSP00000461956	129 (aa)	-	J3KRE2
ENST00000578351	ARHGDIA-204	421	-	ENSP00000462323	92 (aa)	-	J3KS60
ENST00000579121	ARHGDIA-205	637	-	ENSP00000462960	193 (aa)	-	J3KTF8
ENST00000583111	ARHGDIA-212	574	-	-	- (aa)	-	-
ENST00000584461	ARHGDIA-217	886	-	ENSP00000463939	235 (aa)	-	J3QQX2
ENST00000582309	ARHGDIA-209	628	-	-	- (aa)	-	-
ENST00000582520	ARHGDIA-210	245	-	-	- (aa)	-	-
ENST00000541078	ARHGDIA-203	1517	XM_011523574	ENSP00000441348	204 (aa)	XP_011521876	P52565
ENST00000580685	ARHGDIA-207	1201	-	ENSP00000464205	204 (aa)	-	P52565
ENST00000583868	ARHGDIA-215	815	-	ENSP00000462209	249 (aa)	-	J3KRY1
ENST00000583499	ARHGDIA-213	560	-	-	- (aa)	-	-
ENST00000400721	ARHGDIA-202	1568	-	ENSP00000383556	160 (aa)	-	P52565
ENST00000269321	ARHGDIA-201	1906	-	ENSP00000269321	204 (aa)	-	P52565
ENST00000584397	ARHGDIA-216	622	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000141522's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04722	Neurotrophin signaling pathway	KEGG
hsa04962	Vasopressin-regulated water reabsorption	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000141522's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000141522	ARHGDIA	100	100.000	ENSMUSG00000025132	Arhgdia	100	97.059	Mus_musculus
ENSG00000141522	ARHGDIA	89	82.812	ENSMUSG00000030220	Arhgdib	99	75.000	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005094	Rho GDP-dissociation inhibitor activity	21873635.	IBA	Function
GO:0005096	GTPase activator activity	-	IEA	Function
GO:0005515	protein binding	10489445.11513578.17245428.20711218.21044950.21900206.22157745.25416956.25961457.27173435.30337686.	IPI	Function
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005856	cytoskeleton	16130169.	TAS	Component
GO:0007162	negative regulation of cell adhesion	8262133.	TAS	Process
GO:0007266	Rho protein signal transduction	21873635.	IBA	Process
GO:0016020	membrane	21873635.	IBA	Component
GO:0035023	regulation of Rho protein signal transduction	8262133.	IMP	Process
GO:0043066	negative regulation of apoptotic process	16130169.	TAS	Process
GO:0043547	positive regulation of GTPase activity	-	IEA	Process
GO:0048365	Rac GTPase binding	21873635.	IBA	Function
GO:0050771	negative regulation of axonogenesis	-	TAS	Process
GO:0050772	positive regulation of axonogenesis	-	TAS	Process
GO:0051056	regulation of small GTPase mediated signal transduction	-	TAS	Process
GO:0070062	extracellular exosome	19056867.20458337.23533145.	HDA	Component
GO:0071526	semaphorin-plexin signaling pathway	-	ISS	Process
GO:2000249	regulation of actin cytoskeleton reorganization	8262133.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.