EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
18427545	The NMD mRNA surveillance pathway downregulates aberrant E-cadherin transcripts in gastric cancer cells and in CDH1 mutation carriers.	Oncogene	2008 Jul 10	Karam R	doi: 10.1038/onc.2008.62
15796914	Proteomics-based identification of DEAD-box protein 48 as a novel autoantigen, a prospective serum marker for pancreatic cancer.	Biochem Biophys Res Commun	2005 May 6	Xia Q	-
26989025	Long noncoding RNA H19 indicates a poor prognosis of colorectal cancer and promotes tumor growth by recruiting and binding to eIF4A3.	Oncotarget	2016 Apr 19	Han D	doi: 10.18632/oncotarget.8063.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr17	80137452	Nonsense_Mutation	NA	S306*	0.44
BLCA	chr17	80140053	Missense_Mutation	novel	D154H	0.31	DEAD
BLCA	chr17	80136244	Nonsense_Mutation	novel	E359*	0.5
BLCA	chr17	80144239	Missense_Mutation	NA	E59Q	0.08
BLCA	chr17	80140053	Missense_Mutation	novel	D154H	0.08	DEAD
BLCA	chr17	80146842	Missense_Mutation	NA	F40L	0.19
BLCA	chr17	80139746	Missense_Mutation	novel	M170I	0.26	DEAD
BLCA	chr17	80137478	Missense_Mutation	NA	M297I	0.52
BRCA	chr17	80138174	Missense_Mutation	novel	Q279E	0.07
BRCA	chr17	80146921	Missense_Mutation	NA	R14Q	0.24
BRCA	chr17	80136259	Missense_Mutation	NA	L354F	0.15
BRCA	chr17	80136063	Missense_Mutation	NA	R387H	0.23
BRCA	chr17	80136321	Missense_Mutation	NA	S333C	0.23
BRCA	chr17	80140040	Missense_Mutation	NA	H158L	0.23	DEAD
CESC	chr17	80141342	Missense_Mutation	NA	E117Q	0.36	DEAD
CESC	chr17	80135328	3'UTR	novel		0.33
CESC	chr17	80141811	Missense_Mutation	rs757442778	I94V	0.35
CESC	chr17	80139098	Silent	NA	I217I	0.6
COAD	chr17	80136300	Missense_Mutation	NA	G340E	0.17
COAD	chr17	80135316	3'UTR	novel		0.13
COAD	chr17	80136005	Splice_Region	rs143198128	N406N	0.14
COAD	chr17	80139110	Missense_Mutation	novel	Q213H	0.33
COAD	chr17	80140016	Missense_Mutation	novel	R166H	0.45	DEAD
COAD	chr17	80146794	Splice_Region	NA	Y56Y	0.33
COAD	chr17	80139080	Silent	rs535401553	H223H	0.43
COAD	chr17	80144177	Silent	rs747892909	I79I	0.35
COAD	chr17	80138254	Missense_Mutation	novel	K252M	0.15
COAD	chr17	80139027	Missense_Mutation	novel	V241G	0.15
ESCA	chr17	80144185	Missense_Mutation	NA	D77H	0.22
GBM	chr17	80138244	Silent	rs61756263	F255F	0.42
GBM	chr17	80139742	Missense_Mutation	rs200525685	R172C	0.42	DEAD
GBM	chr17	80141832	Nonsense_Mutation	novel	G87*	0.49
HNSC	chr17	80146904	Missense_Mutation	novel	E20Q	0.13
HNSC	chr17	80140072	Silent	rs770103058	G147G	0.33
HNSC	chr17	80137390	Missense_Mutation	rs757676343	A327T	0.22
HNSC	chr17	80141369	Missense_Mutation	novel	Q108E	0.26	DEAD
KIRC	chr17	80140090	Silent	NA	I141I	0.34
KIRC	chr17	80136235	Missense_Mutation	NA	I362V	0.19
KIRP	chr17	80146926	Silent	NA	S12S	0.19
LGG	chr17	80136094	Missense_Mutation	novel	A377T	0.46
LIHC	chr17	80136285	Missense_Mutation	novel	Q345L	0.28
LUAD	chr17	80139687	Missense_Mutation	novel	D190G	0.15	DEAD
LUAD	chr17	80139101	Silent	novel	L216L	0.07
LUSC	chr17	80136242	Silent	novel	E359E	0.11
LUSC	chr17	80137452	Nonsense_Mutation	NA	S306*	0.31
MESO	chr17	80146977	5'UTR	novel		0.35
OV	chr17	80139104	Silent	novel	V215V	0.23
OV	chr17	80138228	Missense_Mutation	NA	E261K	0.18
OV	chr17	80136094	Missense_Mutation	NA	A377P	0.09
OV	chr17	80141815	Silent	NA	F92F	0.06
PAAD	chr17	80138193	Silent	rs752875401	Y272Y	0.2
PAAD	chr17	80146917	Silent	novel	K15K	0.24
READ	chr17	80135374	3'UTR	novel		0.31
READ	chr17	80138244	Silent	rs61756263	F255F	0.16
READ	chr17	80139029	Silent	novel	L240L	0.77
SARC	chr17	80137452	Missense_Mutation	NA	S306L	0.34
SKCM	chr17	80139697	Missense_Mutation	NA	D187N	0.29	DEAD
SKCM	chr17	80140096	Silent	novel	A139A	0.4
SKCM	chr17	80136272	Silent	NA	I349I	0.12
SKCM	chr17	80136289	Missense_Mutation	NA	P344S	0.18
SKCM	chr17	80146910	Missense_Mutation	NA	L18F	0.24
SKCM	chr17	80138244	Silent	rs61756263	F255F	0.15
SKCM	chr17	80138168	Missense_Mutation	novel	V281I	0.22
SKCM	chr17	80146829	Silent	novel	L45L	0.16
STAD	chr17	80137404	Missense_Mutation	NA	E322V	0.16
UCEC	chr17	80144176	Missense_Mutation	NA	A80T	0.42
UCEC	chr17	80136071	Silent	rs374961147	D384D	0.2
UCEC	chr17	80136316	Missense_Mutation	novel	D335N	0.48
UCEC	chr17	80139036	Missense_Mutation	novel	R238H	0.42
UCEC	chr17	80139026	Silent	novel	V241V	0.37
UCEC	chr17	80136105	Missense_Mutation	novel	R373Q	0.42
UCEC	chr17	80139093	Missense_Mutation	novel	A219V	0.51
UCEC	chr17	80136334	Nonsense_Mutation	NA	R329*	0.24
UCEC	chr17	80136275	Silent	NA	L348L	0.16
UCEC	chr17	80136108	Missense_Mutation	novel	G372D	0.38
UCEC	chr17	80136110	Silent	rs759496570	Y371Y	0.47
UCEC	chr17	80140041	Missense_Mutation	novel	H158Y	0.35	DEAD
UCEC	chr17	80136093	Missense_Mutation	novel	A377V	0.5
UCEC	chr17	80141342	Nonsense_Mutation	novel	E117*	0.45	DEAD
UCEC	chr17	80137391	Silent	rs779051281	G326G	0.28
UCEC	chr17	80138244	Silent	rs61756263	F255F	0.22
UCEC	chr17	80137391	Silent	rs779051281	G326G	0.38
UCEC	chr17	80137487	Silent	rs149463025	T294T	0.4
UCEC	chr17	80138215	Missense_Mutation	NA	F265C	0.36
UCEC	chr17	80136334	Nonsense_Mutation	NA	R329*	0.22

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	AMP	0.3946	0.00012456
KIRP	AMP	0.6701	0.14801
LGG	AMP	0.0643	1.52e-05
OV	AMP	0.2746	7.4951e-06
SARC	AMP	0.2218	0.032181
SKCM	AMP	0.2916	7.0388e-08
THCA	DEL	0.002	0.221
UVM	AMP	0.1625	0.054583

Survival Analysis

Cancer	P-value	Q-value
THYM	0.007	Kaplan-Meier Survival Analysis
ACC	0.00011	Kaplan-Meier Survival Analysis
HNSC	0.015	Kaplan-Meier Survival Analysis
ESCA	0.005	Kaplan-Meier Survival Analysis
KIRP	0.00044	Kaplan-Meier Survival Analysis
COAD	0.014	Kaplan-Meier Survival Analysis
BLCA	0.0028	Kaplan-Meier Survival Analysis
CESC	0.019	Kaplan-Meier Survival Analysis
LAML	0.032	Kaplan-Meier Survival Analysis
UCEC	0.01	Kaplan-Meier Survival Analysis
LIHC	0.00043	Kaplan-Meier Survival Analysis
DLBC	0.011	Kaplan-Meier Survival Analysis
THCA	0.017	Kaplan-Meier Survival Analysis
LUAD	0.0079	Kaplan-Meier Survival Analysis
UVM	0.0019	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000141543 (Gene tree)
Gene ID: 9775
Gene Symbol: EIF4A3
Alias: KIAA0111|EIF4AIII|Fal1|DDX48
Full Name: eukaryotic translation initiation factor 4A3
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 11,970 bases
Position: chr17:80,135,214-80,147,183
Accession: 18683
RBP type: canonical RBP
Summary: This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4AI and eIF4AII, two other members of the DEAD box protein family. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000269349	DEAD	PF00270.29	1e-41	1	1
ENSP00000497641	DEAD	PF00270.29	1e-41	1	1
ENSP00000497661	DEAD	PF00270.29	1e-41	1	1
ENSP00000460439	DEAD	PF00270.29	4.2e-30	1	2
ENSP00000460439	DEAD	PF00270.29	4.2e-30	2	2

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
16797590	The three-dimensional arcitecture of the EJC core.	J Mol Biol	2006 Jul 21	Stroupe ME	-
26989025	Long noncoding RNA H19 indicates a poor prognosis of colorectal cancer and promotes tumor growth by recruiting and binding to eIF4A3.	Oncotarget	2016 Apr 19	Han D	doi: 10.18632/oncotarget.8063.
24218557	Crystal structure of the human eIF4AIII-CWC22 complex shows how a DEAD-box protein is inhibited by a MIF4G domain.	Proc Natl Acad Sci U S A	2013 Nov 26	Buchwald G	doi: 10.1073/pnas.1314684110
27475226	Exon Junction Complexes Show a Distributional Bias toward Alternatively Spliced mRNAs and against mRNAs Coding for Ribosomal Proteins.	Cell Rep	2016 Aug 9	Hauer C	doi: 10.1016/j.celrep.2016.06.096
30820140	A splice-site variant in the lncRNA gene RP1-140A9.1 cosegregates in the large Volkmann cataract family.	Mol Vis	2019 Jan 20	Eiberg H	-
16495234	Mutational analysis of human eIF4AIII identifies regions necessary for exon junction complex formation and nonsense-mediated mRNA decay.	RNA	2006 Mar	Shibuya T	-
22961380	Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly.	Nat Struct Mol Biol	2012 Oct	Barbosa I	doi: 10.1038/nsmb.2380
27071691	The exon junction complex in neural development and neurodevelopmental disease.	Int J Dev Neurosci	2016 Dec	McMahon JJ	doi: 10.1016/j.ijdevneu.2016.03.006
27618312	Haploinsufficiency for Core Exon Junction Complex Components Disrupts Embryonic Neurogenesis and Causes p53-Mediated Microcephaly.	PLoS Genet	2016 Sep 12	Mao H	doi: 10.1371/journal.pgen.1006282
23545196	Transcriptome-wide identification of RNA binding sites by CLIP-seq.	Methods	2013 Sep 1	Murigneux V	doi: 10.1016/j.ymeth.2013.03.022
28334780	EIF4A3 deficient human iPSCs and mouse models demonstrate neural crest defects that underlie Richieri-Costa-Pereira syndrome.	Hum Mol Genet	2017 Jun 15	Miller EE	doi: 10.1093/hmg/ddx078.
27071313	Two highly similar DEAD box proteins, OsRH2 and OsRH34, homologous to eukaryotic initiation factor 4AIII, play roles of the exon junction complex in regulating growth and development in rice.	BMC Plant Biol	2016 Apr 12	Huang CK	doi: 10.1186/s12870-016-0769-5.
26773052	A short conserved motif in ALYREF directs cap- and EJC-dependent assembly of export complexes on spliced mRNAs.	Nucleic Acids Res	2016 Mar 18	Gromadzka AM	doi: 10.1093/nar/gkw009
26260686	Improved binding site assignment by high-resolution mapping of RNA-protein interactions using iCLIP.	Nat Commun	2015 Aug 11	Hauer C	doi: 10.1038/ncomms8921.
29791316	Roles of the exon junction complex components in the central nervous system: a mini review.	Rev Neurosci	2018 Nov 27	Bartkowska K	doi: 10.1515/revneuro-2017-0113.
30588240	Systematic Analysis of Gene Expression Alteration and Co-Expression Network of Eukaryotic Initiation Factor 4A-3 in Cancer.	J Cancer	2018 Nov 11	Lin Y	doi: 10.7150/jca.27655
30784594	eIF4A3 Phosphorylation by CDKs Affects NMD during the Cell Cycle.	Cell Rep	2019 Feb 19	Ryu I	doi: 10.1016/j.celrep.2019.01.101.
31069274	Pharmacological systems analysis defines EIF4A3 functions in cell-cycle and RNA stress granule formation.	Commun Biol	2019 May 3	Mazloomian A	doi: 10.1038/s42003-019-0391-9
10523622	Eukaryotic translation initiation factor 4AIII (eIF4AIII) is functionally distinct from eIF4AI and eIF4AII.	Mol Cell Biol	1999 Nov	Li Q	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000575957	EIF4A3-205	574	-	-	- (aa)	-	-
ENST00000575978	EIF4A3-206	3593	-	-	- (aa)	-	-
ENST00000269349	EIF4A3-201	1734	-	ENSP00000269349	411 (aa)	-	P38919
ENST00000576547	EIF4A3-207	1492	XM_011525522	ENSP00000460439	390 (aa)	XP_011523824	I3L3H2
ENST00000570837	EIF4A3-203	534	-	-	- (aa)	-	-
ENST00000649764	EIF4A3-210	1618	-	ENSP00000497641	411 (aa)	-	A0A024R8W0
ENST00000647795	EIF4A3-209	1579	-	ENSP00000497661	411 (aa)	-	A0A024R8W0
ENST00000570625	EIF4A3-202	562	-	-	- (aa)	-	-
ENST00000575668	EIF4A3-204	831	-	-	- (aa)	-	-
ENST00000576573	EIF4A3-208	697	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000141543's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG
hsa03015	mRNA surveillance pathway	KEGG
hsa03040	Spliceosome	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000141543	rs2361710	17	80138078	C	High light scatter reticulocyte percentage of red cells	27863252	[0.028-0.042] unit increase	0.03482019	EFO_0007986
ENSG00000141543	rs2361710	17	80138078	C	Reticulocyte count	27863252	[0.022-0.036] unit increase	0.02926842	EFO_0007986
ENSG00000141543	rs2361710	17	80138078	C	Reticulocyte fraction of red cells	27863252	[0.025-0.039] unit increase	0.03152986	EFO_0007986
ENSG00000141543	rs2361710	17	80138078	C	Immature fraction of reticulocytes	27863252	[0.021-0.035] unit increase	0.02811272	EFO_0007986
ENSG00000141543	rs2361710	17	80138078	C	High light scatter reticulocyte count	27863252	[0.027-0.041] unit increase	0.03386273	EFO_0007986

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000141543's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000141543	EIF4A3	86	33.520	ENSG00000118197	DDX59	92	33.333
ENSG00000141543	EIF4A3	99	66.749	ENSG00000161960	EIF4A1	99	74.138
ENSG00000141543	EIF4A3	92	71.429	ENSG00000156976	EIF4A2	93	71.429
ENSG00000141543	EIF4A3	91	32.316	ENSG00000165732	DDX21	51	32.620
ENSG00000141543	EIF4A3	87	33.333	ENSG00000123064	DDX54	92	34.896
ENSG00000141543	EIF4A3	89	37.270	ENSG00000157349	DDX19B	96	37.190
ENSG00000141543	EIF4A3	90	34.729	ENSG00000067048	DDX3Y	61	34.729
ENSG00000141543	EIF4A3	82	30.362	ENSG00000111364	DDX55	87	32.934
ENSG00000141543	EIF4A3	90	34.577	ENSG00000215301	DDX3X	75	36.740
ENSG00000141543	EIF4A3	82	35.277	ENSG00000100201	DDX17	68	52.632
ENSG00000141543	EIF4A3	90	30.729	ENSG00000198231	DDX42	54	30.287
ENSG00000141543	EIF4A3	91	31.135	ENSG00000105671	DDX49	90	31.481
ENSG00000141543	EIF4A3	90	31.202	ENSG00000152670	DDX4	67	31.525
ENSG00000141543	EIF4A3	89	36.216	ENSG00000123136	DDX39A	92	39.773
ENSG00000141543	EIF4A3	83	31.034	ENSG00000184735	DDX53	55	31.034
ENSG00000141543	EIF4A3	88	38.356	ENSG00000198563	DDX39B	91	36.842
ENSG00000141543	EIF4A3	86	33.154	ENSG00000183258	DDX41	76	31.298
ENSG00000141543	EIF4A3	91	37.831	ENSG00000110367	DDX6	78	37.831
ENSG00000141543	EIF4A3	86	37.741	ENSG00000109832	DDX25	94	41.270
ENSG00000141543	EIF4A3	86	32.888	ENSG00000107625	DDX50	50	32.888
ENSG00000141543	EIF4A3	82	34.857	ENSG00000108654	DDX5	98	32.000
ENSG00000141543	EIF4A3	91	31.903	ENSG00000213782	DDX47	82	31.903
ENSG00000141543	EIF4A3	87	34.877	ENSG00000080007	DDX43	56	34.877
ENSG00000141543	EIF4A3	89	37.533	ENSG00000168872	DDX19A	93	37.701
ENSG00000141543	EIF4A3	92	35.401	ENSG00000064703	DDX20	51	42.857

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000141543	EIF4A3	99	97.537	ENSAPOG00000017112	eif4a3	100	97.537	Acanthochromis_polyacanthus
ENSG00000141543	EIF4A3	99	99.507	ENSAMEG00000015194	EIF4A3	100	99.507	Ailuropoda_melanoleuca
ENSG00000141543	EIF4A3	99	97.537	ENSACIG00000009719	eif4a3	100	97.537	Amphilophus_citrinellus
ENSG00000141543	EIF4A3	99	97.537	ENSAOCG00000021655	eif4a3	100	97.537	Amphiprion_ocellaris
ENSG00000141543	EIF4A3	99	97.537	ENSAPEG00000018658	eif4a3	100	97.537	Amphiprion_percula
ENSG00000141543	EIF4A3	99	97.537	ENSATEG00000014793	eif4a3	100	97.537	Anabas_testudineus
ENSG00000141543	EIF4A3	86	99.716	ENSAPLG00000014717	EIF4A3	100	99.716	Anas_platyrhynchos
ENSG00000141543	EIF4A3	98	99.252	ENSACAG00000014384	EIF4A3	93	99.252	Anolis_carolinensis
ENSG00000141543	EIF4A3	100	99.757	ENSANAG00000005557	EIF4A3	100	99.757	Aotus_nancymaae
ENSG00000141543	EIF4A3	99	97.291	ENSACLG00000004174	eif4a3	100	97.291	Astatotilapia_calliptera
ENSG00000141543	EIF4A3	98	97.525	ENSAMXG00000020882	eif4a3	99	97.778	Astyanax_mexicanus
ENSG00000141543	EIF4A3	100	99.757	ENSBTAG00000016023	EIF4A3	100	99.757	Bos_taurus
ENSG00000141543	EIF4A3	96	87.277	WBGene00018007	F33D11.10	98	87.277	Caenorhabditis_elegans
ENSG00000141543	EIF4A3	96	87.532	WBGene00022029	Y65B4A.6	100	89.247	Caenorhabditis_elegans
ENSG00000141543	EIF4A3	100	99.757	ENSCJAG00000048589	-	100	99.757	Callithrix_jacchus
ENSG00000141543	EIF4A3	100	94.161	ENSCJAG00000016777	-	100	94.161	Callithrix_jacchus
ENSG00000141543	EIF4A3	100	99.513	ENSCAFG00000005614	EIF4A3	100	99.513	Canis_familiaris
ENSG00000141543	EIF4A3	100	99.513	ENSCAFG00020008253	EIF4A3	100	99.513	Canis_lupus_dingo
ENSG00000141543	EIF4A3	100	99.757	ENSCHIG00000024284	EIF4A3	100	99.757	Capra_hircus
ENSG00000141543	EIF4A3	100	99.757	ENSTSYG00000008738	EIF4A3	100	99.757	Carlito_syrichta
ENSG00000141543	EIF4A3	86	97.661	ENSCAPG00000000964	EIF4A3	92	97.661	Cavia_aperea
ENSG00000141543	EIF4A3	100	99.757	ENSCPOG00000006485	EIF4A3	100	99.757	Cavia_porcellus
ENSG00000141543	EIF4A3	100	99.757	ENSCCAG00000036144	EIF4A3	100	99.757	Cebus_capucinus
ENSG00000141543	EIF4A3	100	92.214	ENSCATG00000039629	-	100	92.214	Cercocebus_atys
ENSG00000141543	EIF4A3	100	100.000	ENSCATG00000039262	-	100	100.000	Cercocebus_atys
ENSG00000141543	EIF4A3	100	99.757	ENSCLAG00000014502	EIF4A3	100	99.757	Chinchilla_lanigera
ENSG00000141543	EIF4A3	81	99.096	ENSCPBG00000017801	EIF4A3	98	99.096	Chrysemys_picta_bellii
ENSG00000141543	EIF4A3	98	89.082	ENSCING00000007818	-	98	89.082	Ciona_intestinalis
ENSG00000141543	EIF4A3	90	92.412	ENSCSAVG00000009920	-	100	92.412	Ciona_savignyi
ENSG00000141543	EIF4A3	100	83.846	ENSCANG00000043503	EIF4A3	100	83.846	Colobus_angolensis_palliatus
ENSG00000141543	EIF4A3	100	99.513	ENSCGRG00001022918	-	100	99.513	Cricetulus_griseus_chok1gshd
ENSG00000141543	EIF4A3	99	82.222	ENSCGRG00001018048	-	100	82.222	Cricetulus_griseus_chok1gshd
ENSG00000141543	EIF4A3	99	81.975	ENSCGRG00000001983	-	99	83.193	Cricetulus_griseus_crigri
ENSG00000141543	EIF4A3	86	100.000	ENSCGRG00000017119	-	100	100.000	Cricetulus_griseus_crigri
ENSG00000141543	EIF4A3	98	97.525	ENSCSEG00000021058	eif4a3	99	97.525	Cynoglossus_semilaevis
ENSG00000141543	EIF4A3	99	97.537	ENSCVAG00000006864	eif4a3	100	97.537	Cyprinodon_variegatus
ENSG00000141543	EIF4A3	99	97.044	ENSDARG00000102978	eif4a3	100	97.044	Danio_rerio
ENSG00000141543	EIF4A3	86	100.000	ENSDNOG00000009027	EIF4A3	96	100.000	Dasypus_novemcinctus
ENSG00000141543	EIF4A3	100	99.757	ENSDORG00000013028	-	100	99.757	Dipodomys_ordii
ENSG00000141543	EIF4A3	97	87.719	FBgn0037573	CG7483	99	87.719	Drosophila_melanogaster
ENSG00000141543	EIF4A3	97	95.214	ENSEBUG00000003713	eif4a3	92	95.214	Eptatretus_burgeri
ENSG00000141543	EIF4A3	100	99.757	ENSEASG00005005107	EIF4A3	100	99.757	Equus_asinus_asinus
ENSG00000141543	EIF4A3	100	99.757	ENSECAG00000015925	EIF4A3	100	99.757	Equus_caballus
ENSG00000141543	EIF4A3	100	93.431	ENSEEUG00000006008	EIF4A3	100	93.431	Erinaceus_europaeus
ENSG00000141543	EIF4A3	97	98.489	ENSELUG00000018528	eif4a3	98	98.489	Esox_lucius
ENSG00000141543	EIF4A3	100	99.757	ENSFCAG00000008246	EIF4A3	100	99.757	Felis_catus
ENSG00000141543	EIF4A3	86	100.000	ENSFALG00000002343	EIF4A3	100	100.000	Ficedula_albicollis
ENSG00000141543	EIF4A3	100	99.757	ENSFDAG00000020774	EIF4A3	100	99.757	Fukomys_damarensis
ENSG00000141543	EIF4A3	95	97.959	ENSGMOG00000001560	eif4a3	100	97.959	Gadus_morhua
ENSG00000141543	EIF4A3	99	97.561	ENSGALG00000008530	EIF4A3	99	97.561	Gallus_gallus
ENSG00000141543	EIF4A3	99	97.783	ENSGAFG00000013487	eif4a3	100	97.783	Gambusia_affinis
ENSG00000141543	EIF4A3	99	96.798	ENSGACG00000020004	eif4a3	100	96.798	Gasterosteus_aculeatus
ENSG00000141543	EIF4A3	98	98.762	ENSGAGG00000016434	EIF4A3	99	98.762	Gopherus_agassizii
ENSG00000141543	EIF4A3	100	100.000	ENSGGOG00000012918	EIF4A3	100	100.000	Gorilla_gorilla
ENSG00000141543	EIF4A3	99	97.537	ENSHBUG00000014892	eif4a3	100	97.537	Haplochromis_burtoni
ENSG00000141543	EIF4A3	100	99.757	ENSHGLG00000004635	EIF4A3	100	99.757	Heterocephalus_glaber_female
ENSG00000141543	EIF4A3	100	99.757	ENSHGLG00100006837	EIF4A3	100	99.757	Heterocephalus_glaber_male
ENSG00000141543	EIF4A3	97	83.619	ENSHCOG00000011335	eif4a3	88	83.619	Hippocampus_comes
ENSG00000141543	EIF4A3	98	97.525	ENSIPUG00000021785	eif4a3	99	97.525	Ictalurus_punctatus
ENSG00000141543	EIF4A3	100	99.757	ENSSTOG00000002664	EIF4A3	100	99.757	Ictidomys_tridecemlineatus
ENSG00000141543	EIF4A3	100	99.513	ENSJJAG00000015870	-	100	99.513	Jaculus_jaculus
ENSG00000141543	EIF4A3	100	99.027	ENSJJAG00000016503	-	100	99.027	Jaculus_jaculus
ENSG00000141543	EIF4A3	97	94.264	ENSKMAG00000010113	eif4a3	93	94.264	Kryptolebias_marmoratus
ENSG00000141543	EIF4A3	88	97.245	ENSLBEG00000020356	eif4a3	97	97.245	Labrus_bergylta
ENSG00000141543	EIF4A3	97	97.750	ENSLACG00000000108	EIF4A3	99	97.750	Latimeria_chalumnae
ENSG00000141543	EIF4A3	98	97.772	ENSLOCG00000015796	eif4a3	98	97.772	Lepisosteus_oculatus
ENSG00000141543	EIF4A3	100	99.757	ENSLAFG00000015628	EIF4A3	100	99.757	Loxodonta_africana
ENSG00000141543	EIF4A3	99	89.461	ENSMFAG00000018955	-	99	89.461	Macaca_fascicularis
ENSG00000141543	EIF4A3	100	100.000	ENSMFAG00000043778	EIF4A3	100	100.000	Macaca_fascicularis
ENSG00000141543	EIF4A3	100	89.538	ENSMMUG00000007050	-	100	89.538	Macaca_mulatta
ENSG00000141543	EIF4A3	100	99.757	ENSMMUG00000009590	EIF4A3	100	100.000	Macaca_mulatta
ENSG00000141543	EIF4A3	99	100.000	ENSMNEG00000039333	-	95	100.000	Macaca_nemestrina
ENSG00000141543	EIF4A3	99	89.461	ENSMNEG00000038447	-	100	90.274	Macaca_nemestrina
ENSG00000141543	EIF4A3	86	100.000	ENSMLEG00000032948	EIF4A3	100	100.000	Mandrillus_leucophaeus
ENSG00000141543	EIF4A3	99	97.537	ENSMAMG00000017369	eif4a3	100	97.537	Mastacembelus_armatus
ENSG00000141543	EIF4A3	99	90.394	ENSMZEG00005015371	eif4a3	100	90.674	Maylandia_zebra
ENSG00000141543	EIF4A3	99	97.537	ENSMZEG00005000259	-	100	97.537	Maylandia_zebra
ENSG00000141543	EIF4A3	86	100.000	ENSMGAG00000007270	EIF4A3	100	100.000	Meleagris_gallopavo
ENSG00000141543	EIF4A3	100	99.513	ENSMAUG00000012955	-	100	99.513	Mesocricetus_auratus
ENSG00000141543	EIF4A3	100	93.735	ENSMICG00000009136	-	100	93.735	Microcebus_murinus
ENSG00000141543	EIF4A3	99	92.346	ENSMICG00000044243	-	100	92.346	Microcebus_murinus
ENSG00000141543	EIF4A3	99	92.593	ENSMICG00000045127	-	100	92.593	Microcebus_murinus
ENSG00000141543	EIF4A3	99	93.842	ENSMICG00000041585	-	98	93.842	Microcebus_murinus
ENSG00000141543	EIF4A3	99	97.531	ENSMICG00000034467	-	100	97.531	Microcebus_murinus
ENSG00000141543	EIF4A3	99	89.756	ENSMICG00000011946	-	99	89.756	Microcebus_murinus
ENSG00000141543	EIF4A3	100	99.558	ENSMOCG00000017297	-	100	73.861	Microtus_ochrogaster
ENSG00000141543	EIF4A3	98	91.852	ENSMMOG00000018352	eif4a3	93	91.852	Mola_mola
ENSG00000141543	EIF4A3	100	99.757	ENSMODG00000002190	-	100	99.757	Monodelphis_domestica
ENSG00000141543	EIF4A3	100	92.457	ENSMODG00000003697	-	100	92.457	Monodelphis_domestica
ENSG00000141543	EIF4A3	99	97.291	ENSMALG00000016324	eif4a3	100	97.291	Monopterus_albus
ENSG00000141543	EIF4A3	100	99.513	MGP_CAROLIEiJ_G0017495	-	100	99.513	Mus_caroli
ENSG00000141543	EIF4A3	100	97.810	ENSMUSG00000107906	Gm5580	100	97.810	Mus_musculus
ENSG00000141543	EIF4A3	100	99.270	ENSMUSG00000025580	Eif4a3	100	99.270	Mus_musculus
ENSG00000141543	EIF4A3	100	96.837	ENSMUSG00000094973	Gm8994	100	96.837	Mus_musculus
ENSG00000141543	EIF4A3	100	99.757	MGP_PahariEiJ_G0018622	-	100	99.757	Mus_pahari
ENSG00000141543	EIF4A3	100	99.757	MGP_SPRETEiJ_G0018339	Eif4a3	100	99.757	Mus_spretus
ENSG00000141543	EIF4A3	86	100.000	ENSMPUG00000012216	EIF4A3	84	100.000	Mustela_putorius_furo
ENSG00000141543	EIF4A3	87	84.594	ENSMLUG00000024690	-	100	84.594	Myotis_lucifugus
ENSG00000141543	EIF4A3	100	92.457	ENSMLUG00000012233	-	100	92.457	Myotis_lucifugus
ENSG00000141543	EIF4A3	84	96.812	ENSMLUG00000009585	-	100	96.812	Myotis_lucifugus
ENSG00000141543	EIF4A3	100	99.757	ENSNGAG00000003189	-	100	99.757	Nannospalax_galili
ENSG00000141543	EIF4A3	98	97.772	ENSNBRG00000021671	eif4a3	99	97.772	Neolamprologus_brichardi
ENSG00000141543	EIF4A3	100	100.000	ENSNLEG00000015595	EIF4A3	100	100.000	Nomascus_leucogenys
ENSG00000141543	EIF4A3	100	88.564	ENSMEUG00000008521	EIF4A3	100	88.564	Notamacropus_eugenii
ENSG00000141543	EIF4A3	100	99.757	ENSODEG00000010300	EIF4A3	100	99.757	Octodon_degus
ENSG00000141543	EIF4A3	98	97.772	ENSONIG00000019828	eif4a3	99	97.772	Oreochromis_niloticus
ENSG00000141543	EIF4A3	70	95.105	ENSOANG00000000334	EIF4A3	100	95.105	Ornithorhynchus_anatinus
ENSG00000141543	EIF4A3	99	97.783	ENSORLG00000018405	eif4a3	100	97.783	Oryzias_latipes
ENSG00000141543	EIF4A3	99	97.783	ENSOMEG00000007998	eif4a3	100	97.783	Oryzias_melastigma
ENSG00000141543	EIF4A3	100	99.757	ENSOGAG00000007495	-	100	99.757	Otolemur_garnettii
ENSG00000141543	EIF4A3	100	99.270	ENSOGAG00000026206	-	100	99.270	Otolemur_garnettii
ENSG00000141543	EIF4A3	100	99.757	ENSOARG00000002169	-	100	99.757	Ovis_aries
ENSG00000141543	EIF4A3	100	96.107	ENSOARG00000005144	-	100	96.107	Ovis_aries
ENSG00000141543	EIF4A3	81	93.093	ENSPPAG00000021017	-	89	92.771	Pan_paniscus
ENSG00000141543	EIF4A3	100	99.757	ENSPPRG00000021873	EIF4A3	100	99.757	Panthera_pardus
ENSG00000141543	EIF4A3	88	98.611	ENSPTIG00000009646	EIF4A3	99	98.611	Panthera_tigris_altaica
ENSG00000141543	EIF4A3	100	97.573	ENSPTRG00000009737	EIF4A3	100	97.573	Pan_troglodytes
ENSG00000141543	EIF4A3	100	90.754	ENSPANG00000021217	-	100	90.754	Papio_anubis
ENSG00000141543	EIF4A3	100	100.000	ENSPANG00000019672	-	100	100.000	Papio_anubis
ENSG00000141543	EIF4A3	98	96.782	ENSPKIG00000016912	eif4a3	99	96.782	Paramormyrops_kingsleyae
ENSG00000141543	EIF4A3	72	100.000	ENSPSIG00000004036	EIF4A3	100	100.000	Pelodiscus_sinensis
ENSG00000141543	EIF4A3	100	99.757	ENSPEMG00000009441	-	100	99.757	Peromyscus_maniculatus_bairdii
ENSG00000141543	EIF4A3	87	99.440	ENSPCIG00000005856	-	98	100.000	Phascolarctos_cinereus
ENSG00000141543	EIF4A3	99	97.073	ENSPFOG00000009300	eif4a3	99	97.073	Poecilia_formosa
ENSG00000141543	EIF4A3	99	97.783	ENSPLAG00000007436	eif4a3	100	97.783	Poecilia_latipinna
ENSG00000141543	EIF4A3	99	97.783	ENSPMEG00000008078	eif4a3	100	97.783	Poecilia_mexicana
ENSG00000141543	EIF4A3	99	98.030	ENSPREG00000006006	eif4a3	100	98.030	Poecilia_reticulata
ENSG00000141543	EIF4A3	100	100.000	ENSPPYG00000008714	EIF4A3	100	100.000	Pongo_abelii
ENSG00000141543	EIF4A3	98	84.080	ENSPCAG00000002931	EIF4A3	100	83.942	Procavia_capensis
ENSG00000141543	EIF4A3	100	99.757	ENSPCOG00000020004	EIF4A3	100	99.757	Propithecus_coquereli
ENSG00000141543	EIF4A3	100	99.757	ENSPVAG00000003627	EIF4A3	100	99.757	Pteropus_vampyrus
ENSG00000141543	EIF4A3	99	97.537	ENSPNYG00000016865	eif4a3	100	97.537	Pundamilia_nyererei
ENSG00000141543	EIF4A3	98	97.030	ENSPNAG00000008053	eif4a3	99	97.030	Pygocentrus_nattereri
ENSG00000141543	EIF4A3	100	99.757	ENSRNOG00000045791	Eif4a3	100	99.757	Rattus_norvegicus
ENSG00000141543	EIF4A3	100	100.000	ENSRBIG00000029705	EIF4A3	100	100.000	Rhinopithecus_bieti
ENSG00000141543	EIF4A3	100	100.000	ENSRROG00000042322	EIF4A3	100	100.000	Rhinopithecus_roxellana
ENSG00000141543	EIF4A3	91	64.516	YJL138C	TIF2	94	64.516	Saccharomyces_cerevisiae
ENSG00000141543	EIF4A3	95	61.772	YDR021W	-	99	61.772	Saccharomyces_cerevisiae
ENSG00000141543	EIF4A3	91	64.516	YKR059W	TIF1	94	64.516	Saccharomyces_cerevisiae
ENSG00000141543	EIF4A3	100	99.757	ENSSBOG00000024694	EIF4A3	100	99.757	Saimiri_boliviensis_boliviensis
ENSG00000141543	EIF4A3	100	99.027	ENSSHAG00000004638	-	92	99.027	Sarcophilus_harrisii
ENSG00000141543	EIF4A3	100	98.783	ENSSHAG00000005751	-	100	98.783	Sarcophilus_harrisii
ENSG00000141543	EIF4A3	98	96.782	ENSSFOG00015022017	eif4a3	99	96.782	Scleropages_formosus
ENSG00000141543	EIF4A3	98	97.030	ENSSFOG00015004896	-	99	97.030	Scleropages_formosus
ENSG00000141543	EIF4A3	98	97.650	ENSSMAG00000021078	eif4a3	99	97.650	Scophthalmus_maximus
ENSG00000141543	EIF4A3	98	98.020	ENSSDUG00000021512	eif4a3	99	98.020	Seriola_dumerili
ENSG00000141543	EIF4A3	88	97.238	ENSSLDG00000010112	eif4a3	93	97.238	Seriola_lalandi_dorsalis
ENSG00000141543	EIF4A3	55	100.000	ENSSARG00000009017	-	100	100.000	Sorex_araneus
ENSG00000141543	EIF4A3	99	98.771	ENSSPUG00000013935	EIF4A3	99	98.771	Sphenodon_punctatus
ENSG00000141543	EIF4A3	97	97.756	ENSSPAG00000017012	eif4a3	98	97.756	Stegastes_partitus
ENSG00000141543	EIF4A3	100	99.757	ENSSSCG00000017155	EIF4A3	100	99.757	Sus_scrofa
ENSG00000141543	EIF4A3	80	100.000	ENSTGUG00000002132	EIF4A3	100	100.000	Taeniopygia_guttata
ENSG00000141543	EIF4A3	99	97.537	ENSTRUG00000011543	eif4a3	100	97.537	Takifugu_rubripes
ENSG00000141543	EIF4A3	99	97.304	ENSTNIG00000002924	eif4a3	99	97.304	Tetraodon_nigroviridis
ENSG00000141543	EIF4A3	86	88.983	ENSTTRG00000000514	EIF4A3	100	88.983	Tursiops_truncatus
ENSG00000141543	EIF4A3	100	99.757	ENSUAMG00000027453	EIF4A3	100	99.757	Ursus_americanus
ENSG00000141543	EIF4A3	93	93.766	ENSUMAG00000014617	EIF4A3	99	99.432	Ursus_maritimus
ENSG00000141543	EIF4A3	100	99.513	ENSVVUG00000017984	EIF4A3	100	99.513	Vulpes_vulpes
ENSG00000141543	EIF4A3	100	96.386	ENSXETG00000013720	eif4a3	100	96.386	Xenopus_tropicalis
ENSG00000141543	EIF4A3	97	97.756	ENSXCOG00000010824	eif4a3	98	97.756	Xiphophorus_couchianus
ENSG00000141543	EIF4A3	99	97.783	ENSXMAG00000014111	eif4a3	100	97.783	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	16209946.	IMP	Process
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	-	TAS	Process
GO:0000398	mRNA splicing, via spliceosome	11991638.	IC	Process
GO:0000398	mRNA splicing, via spliceosome	29301961.	IDA	Process
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003729	mRNA binding	22961380.	IDA	Function
GO:0004004	ATP-dependent RNA helicase activity	10523622.	IDA	Function
GO:0005515	protein binding	10523622.14730019.14973490.15361857.16170325.16189514.16209946.16601204.16923391.18066079.18423201.19410547.19417104.19478851.20123736.20479275.21576267.22365833.22522823.22961380.23084401.23236153.25416956.26382858.29997244.	IPI	Function
GO:0005524	ATP binding	10523622.	IDA	Function
GO:0005634	nucleus	29301961.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	10523622.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006364	rRNA processing	-	IEA	Process
GO:0006405	RNA export from nucleus	-	TAS	Process
GO:0006406	mRNA export from nucleus	-	TAS	Process
GO:0008143	poly(A) binding	10523622.	IDA	Function
GO:0008306	associative learning	-	IEA	Process
GO:0014070	response to organic cyclic compound	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016607	nuclear speck	-	IEA	Component
GO:0017148	negative regulation of translation	10523622.	IDA	Process
GO:0030425	dendrite	-	IEA	Component
GO:0031124	mRNA 3'-end processing	-	TAS	Process
GO:0035145	exon-exon junction complex	16601204.	IDA	Component
GO:0035368	selenocysteine insertion sequence binding	-	IEA	Function
GO:0035613	RNA stem-loop binding	-	IEA	Function
GO:0035640	exploration behavior	-	IEA	Process
GO:0043021	ribonucleoprotein complex binding	-	IEA	Function
GO:0043025	neuronal cell body	-	IEA	Component
GO:0045182	translation regulator activity	-	IEA	Function
GO:0045727	positive regulation of translation	18423201.	IMP	Process
GO:0048701	embryonic cranial skeleton morphogenesis	24360810.	IMP	Process
GO:0071006	U2-type catalytic step 1 spliceosome	29301961.	IDA	Component
GO:0071013	catalytic step 2 spliceosome	11991638.22961380.	IDA	Component
GO:0072715	cellular response to selenite ion	-	IEA	Process
GO:0090394	negative regulation of excitatory postsynaptic potential	-	IEA	Process
GO:0098978	glutamatergic synapse	-	IEA	Component
GO:0099524	postsynaptic cytosol	-	IEA	Component
GO:0099578	regulation of translation at postsynapse, modulating synaptic transmission	-	IEA	Process
GO:1904570	negative regulation of selenocysteine incorporation	-	IEA	Process
GO:1904574	negative regulation of selenocysteine insertion sequence binding	-	IEA	Process
GO:1990416	cellular response to brain-derived neurotrophic factor stimulus	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.