EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
18776922	Regulation of androgen receptor transcriptional activity by rapamycin in prostate cancer cell proliferation and survival.	Oncogene	2008 Nov 27	Wang Y	doi: 10.1038/onc.2008.318
23423739	Genetic variations of mTORC1 genes and risk of gastric cancer in an Eastern Chinese population.	Mol Carcinog	2013 Nov	He J	doi: 10.1002/mc.22013
27211906	Differential effects of rapalogues, dual kinase inhibitors on human ovarian carcinoma cells in vitro.	Int J Oncol	2016 Jul	Rogers-Broadway KR	doi: 10.3892/ijo.2016.3531
27577081	DNA methylation array analysis identifies breast cancer associated RPTOR, MGRN1 and RAPSN hypomethylation in peripheral blood DNA.	Oncotarget	2016 Sep 27	Tang Q	doi: 10.18632/oncotarget.11640.
29344641	Inhibition of RPTOR overcomes resistance to EGFR inhibition in triple-negative breast cancer cells.	Int J Oncol	2018 Mar	You KS	doi: 10.3892/ijo.2018.4244
29128895	Raptor localization predicts prognosis and tamoxifen response in estrogen receptor-positive breast cancer.	Breast Cancer Res Treat	2018 Feb	Bostner J	doi: 10.1007/s10549-017-4508-x

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr17	80960174	Missense_Mutation	rs375708825	V1192I	0.21
BLCA	chr17	80846540	Missense_Mutation	novel	R427Q	0.22
BLCA	chr17	80730598	Silent	NA	L182L	0.12
BLCA	chr17	80960123	Missense_Mutation	novel	D1175N	0.15
BLCA	chr17	80962569	Silent	NA	L1267L	0.19
BLCA	chr17	80893787	Missense_Mutation	novel	E775K	0.19
BLCA	chr17	80891758	Nonsense_Mutation	novel	Y674*	0.44
BLCA	chr17	80960112	Missense_Mutation	novel	S1171N	0.16
BLCA	chr17	80923645	Missense_Mutation	NA	R927L	0.61
BLCA	chr17	80923646	Silent	novel	R927R	0.61
BLCA	chr17	80730587	Missense_Mutation	novel	I179V	0.44
BLCA	chr17	80822246	Silent	novel	L312L	0.37
BLCA	chr17	80949468	Silent	NA	K1097K	0.12
BLCA	chr17	80823130	Missense_Mutation	novel	R348P	0.07
BLCA	chr17	80822225	Missense_Mutation	novel	R305S	0.05
BLCA	chr17	80857889	Missense_Mutation	rs755927307	A500T	0.27
BLCA	chr17	80908839	Missense_Mutation	novel	Q810H	0.07
BLCA	chr17	80857977	Intron	novel		0.8
BLCA	chr17	80545760	Missense_Mutation	NA	S44C	0.18
BRCA	chr17	80625751	Missense_Mutation	novel	V75L	0.09
BRCA	chr17	80823175	Missense_Mutation	NA	T363I	0.19
BRCA	chr17	80846539	Nonsense_Mutation	NA	R427*	0.13
BRCA	chr17	80940564	Silent	novel	S996S	0.25
BRCA	chr17	80957683	Missense_Mutation	rs766868607	V1144M	0.41
BRCA	chr17	80837986	Missense_Mutation	NA	T401S	0.3
BRCA	chr17	80960118	Frame_Shift_Del	NA	*C1174Vfs32**	0.51
BRCA	chr17	80923583	Silent	rs199647030	P906P	0.65
BRCA	chr17	80962501	Missense_Mutation	NA	E1245K	0.33
BRCA	chr17	80893761	Missense_Mutation	NA	S766T	0.4
BRCA	chr17	80545579	5'UTR	novel		0.64
BRCA	chr17	80545126	5'Flank	novel		0.16
BRCA	chr17	80892856	Silent	novel	S743S	0.05
BRCA	chr17	80730622	Silent	NA	S190S	0.24
BRCA	chr17	80837944	Missense_Mutation	NA	D387H	0.28
BRCA	chr17	80893710	Missense_Mutation	NA	G749V	0.49
CESC	chr17	80593312	Intron	novel		0.48
CESC	chr17	80544975	5'Flank	novel		0.16
CESC	chr17	80961453	Missense_Mutation	rs143802144	R1222H	0.29
CESC	chr17	80964319	Missense_Mutation	novel	R1333C	0.25
CESC	chr17	80707908	Missense_Mutation	rs767783333	R139H	0.29
CESC	chr17	80823182	Silent	NA	V365V	0.72
CESC	chr17	80923621	Frame_Shift_Del	novel	*H919Pfs54**	0.1
CESC	chr17	80544903	5'Flank	NA		0.23
CESC	chr17	80545272	5'UTR	novel		0.17
CESC	chr17	80945752	Silent	novel	C1037C	0.43
CESC	chr17	80957640	Silent	rs528225387	V1129V	0.34
CESC	chr17	80962477	Missense_Mutation	novel	R1237C	0.29
CESC	chr17	80822223	Missense_Mutation	novel	R305G	0.27
CESC	chr17	80823186	Missense_Mutation	NA	S367C	0.44
CESC	chr17	80883850	Frame_Shift_Ins	novel	*R574Qfs29**	0.06
CESC	chr17	80885068	Missense_Mutation	NA	D635N	0.38
CESC	chr17	80892783	Missense_Mutation	NA	S719F	0.63
CESC	chr17	80883441	Missense_Mutation	NA	A536V	0.57
COAD	chr17	80823180	Missense_Mutation	NA	V365I	0.18
COAD	chr17	80823189	Missense_Mutation	NA	P368S	0.24
COAD	chr17	80893780	Silent	NA	P772P	0.31
COAD	chr17	80908890	Silent	novel	S827S	0.64
COAD	chr17	80957640	Silent	novel	V1129V	0.19
COAD	chr17	80925422	Missense_Mutation	rs150835528	T954M	0.35
COAD	chr17	80707844	Missense_Mutation	NA	R118W	0.13
COAD	chr17	80925418	Missense_Mutation	rs201551267	A953T	0.38
COAD	chr17	80883837	Silent	rs7210571	P569P	0.52
COAD	chr17	80707905	Missense_Mutation	novel	R138H	0.72
COAD	chr17	80643743	Missense_Mutation	NA	G94D	0.45
COAD	chr17	80940565	Missense_Mutation	rs201400170	R997C	0.53
COAD	chr17	80883851	Missense_Mutation	novel	R574H	0.44
COAD	chr17	80957702	Nonsense_Mutation	novel	W1150*	0.26
COAD	chr17	80962525	Missense_Mutation	NA	V1253L	0.64
COAD	chr17	80883932	Missense_Mutation	NA	H601R	0.23
COAD	chr17	80885128	Missense_Mutation	NA	G655R	0.09
COAD	chr17	80945737	Missense_Mutation	novel	H1032Q	0.38
COAD	chr17	80945739	Missense_Mutation	novel	P1033H	0.36
COAD	chr17	80891768	Missense_Mutation	novel	F678V	0.28
COAD	chr17	80945764	Silent	rs199631709	A1041A	0.22
COAD	chr17	80883894	Silent	rs146893435	F588F	0.29
COAD	chr17	80962538	Missense_Mutation	novel	T1257M	0.1
COAD	chr17	80545567	5'UTR	novel		0.41
COAD	chr17	80823293	Intron	novel		0.22
COAD	chr17	80822212	Missense_Mutation	NA	R301H	0.35
COAD	chr17	80707941	Missense_Mutation	novel	Y150C	0.16
COAD	chr17	80925431	Missense_Mutation	rs200514795	T957M	0.21
COAD	chr17	80754120	Silent	novel	I255I	0.25
COAD	chr17	80925440	Missense_Mutation	NA	C960Y	0.2
COAD	chr17	80961453	Missense_Mutation	rs143802144	R1222H	0.18
ESCA	chr17	80891747	Missense_Mutation	novel	V671L	0.2
ESCA	chr17	80593321	Intron	novel		0.26
ESCA	chr17	80730674	Nonsense_Mutation	novel	Q208*	0.16
GBM	chr17	80707927	Silent	novel	R145R	0.06
GBM	chr17	80923533	Frame_Shift_Del	novel	*N890Tfs83**	0.42
GBM	chr17	80823200	Silent	rs746590620	P371P	0.36
GBM	chr17	80707981	Missense_Mutation	novel	E163D	0.24
GBM	chr17	80823130	Missense_Mutation	NA	R348Q	0.5
GBM	chr17	80754163	Missense_Mutation	novel	P270S	0.12
GBM	chr17	80857904	Splice_Region	novel		0.17
GBM	chr17	80964260	Splice_Site	NA	X1314_splice	0.28
HNSC	chr17	80908929	Splice_Region	novel	K840K	0.25
HNSC	chr17	80925384	Silent	rs181542338	A941A	0.17
HNSC	chr17	80964309	Silent	rs769703866	S1329S	0.33
HNSC	chr17	80925397	Missense_Mutation	rs200090551	G946R	0.4
HNSC	chr17	80925398	Missense_Mutation	novel	G946E	0.37
HNSC	chr17	80923495	Missense_Mutation	rs768404459	S877F	0.22
HNSC	chr17	80707990	Silent	novel	V166V	0.16
HNSC	chr17	80908891	Missense_Mutation	novel	D828N	0.05
HNSC	chr17	80885059	Missense_Mutation	novel	E632Q	0.19
HNSC	chr17	80707974	Missense_Mutation	novel	N161S	0.24
HNSC	chr17	80823237	Intron	novel		0.24
KICH	chr17	80892765	Missense_Mutation	novel	C713F	0.62
KIRC	chr17	80730564	Missense_Mutation	NA	Y171S	0.31
KIRC	chr17	80945725	Silent	novel	V1028V	0.22
KIRC	chr17	80754175	Missense_Mutation	rs148973724	A274T	0.35
KIRP	chr17	80837924	Missense_Mutation	NA	Q380P	0.21
LIHC	chr17	80730630	Missense_Mutation	novel	V193A	0.33
LIHC	chr17	80945746	Silent	rs145803652	T1035T	0.48
LIHC	chr17	80823257	Intron	novel		0.38
LIHC	chr17	80822282	Silent	rs375226529	A324A	0.28
LIHC	chr17	80945749	Silent	novel	P1036P	0.35
LIHC	chr17	80957702	Missense_Mutation	novel	W1150L	0.42
LIHC	chr17	80957703	Missense_Mutation	novel	W1150C	0.41
LIHC	chr17	80730629	Missense_Mutation	NA	V193I	0.13
LIHC	chr17	80883815	Missense_Mutation	NA	C562Y	0.3
LUAD	chr17	80707841	Missense_Mutation	NA	A117S	0.15
LUAD	chr17	80822241	Missense_Mutation	novel	E311K	0.13
LUAD	chr17	80947315	Missense_Mutation	novel	N1077D	0.17
LUAD	chr17	80837991	Silent	rs747216581	A402A	0.29
LUAD	chr17	80908894	Missense_Mutation	novel	V829L	0.28
LUAD	chr17	80923645	Missense_Mutation	NA	R927L	0.43
LUAD	chr17	80625761	Missense_Mutation	NA	T78N	0.24
LUAD	chr17	80754094	Missense_Mutation	rs778029024	E247K	0.2
LUAD	chr17	80949470	Frame_Shift_Ins	novel	*A1100Cfs2**	0.14
LUAD	chr17	80643795	Silent	novel	E111E	0.1
LUAD	chr17	80957671	Missense_Mutation	NA	S1140C	0.15
LUAD	chr17	80707905	Missense_Mutation	NA	R138L	0.43
LUAD	chr17	80885047	Missense_Mutation	novel	G628C	0.55
LUAD	chr17	80949459	Missense_Mutation	novel	R1094S	0.04
LUAD	chr17	80823334	Intron	novel		0.5
LUAD	chr17	80625730	Frame_Shift_Ins	novel	*G69Wfs56**	0.19
LUAD	chr17	80730706	Splice_Region	novel	E218E	0.08
LUAD	chr17	80957686	Missense_Mutation	NA	R1145W	0.42
LUAD	chr17	80730629	Missense_Mutation	NA	V193I	0.23
LUSC	chr17	80823261	Intron	rs753755968		0.39
LUSC	chr17	80885044	Missense_Mutation	novel	V627L	0.47
LUSC	chr17	80730629	Missense_Mutation	novel	V193F	0.97
LUSC	chr17	80545770	Silent	novel	Q47Q	0.31
LUSC	chr17	80957727	Silent	novel	V1158V	0.47
LUSC	chr17	80892795	Missense_Mutation	novel	Y723C	0.32
LUSC	chr17	80947239	Nonsense_Mutation	NA	W1051*	0.18
LUSC	chr17	80964406	3'UTR	novel		0.19
LUSC	chr17	80822299	Missense_Mutation	rs201102317	R330Q	0.35
LUSC	chr17	80893768	Silent	NA	T768T	0.15
LUSC	chr17	80964410	3'UTR	novel		0.44
LUSC	chr17	80823251	Intron	novel		0.46
MESO	chr17	80545633	Missense_Mutation	novel	E2K	0.28
MESO	chr17	80545634	Missense_Mutation	novel	E2V	0.28
MESO	chr17	80964274	Missense_Mutation	rs371220837	V1318M	0.05
OV	chr17	80823152	Silent	novel	R355R	0.05
OV	chr17	80960151	Missense_Mutation	NA	G1184A	0.19
OV	chr17	80947239	Missense_Mutation	novel	W1051C	0.13
OV	chr17	80545553	5'UTR	novel		0.62
OV	chr17	80545514	5'UTR	novel		0.29
OV	chr17	80823343	Intron	novel		0.2
OV	chr17	80892814	Nonsense_Mutation	novel	*V729_A730insSLFFSSFAP**	0.06
OV	chr17	80545506	5'UTR	novel		0.95
OV	chr17	80730693	Missense_Mutation	novel	E214G	0.05
PAAD	chr17	80545614	5'UTR	rs773365928		0.19
PAAD	chr17	80707908	Missense_Mutation	rs767783333	R139H	0.16
PAAD	chr17	80822255	Silent	novel	I315I	0.16
PAAD	chr17	80949509	Missense_Mutation	novel	A1111V	0.18
PAAD	chr17	80960143	Silent	rs138030342	I1181I	0.12
PAAD	chr17	80949528	Missense_Mutation	rs760760990	D1117E	0.06
PRAD	chr17	80823238	Intron	novel		0.29
PRAD	chr17	80857853	Missense_Mutation	novel	R488G	0.17
PRAD	chr17	80857854	Missense_Mutation	rs780248757	R488Q	0.13
PRAD	chr17	80883460	Silent	rs750153454	I542I	0.28
PRAD	chr17	80883902	Missense_Mutation	novel	A591V	0.2
PRAD	chr17	80880464	Missense_Mutation	NA	S520L	0.33
READ	chr17	80880465	Silent	rs146549130	S520S	0.13
READ	chr17	80730577	Silent	NA	I175I	0.21
READ	chr17	80883815	Missense_Mutation	NA	C562F	0.91
READ	chr17	80892840	Missense_Mutation	novel	S738Y	0.4
READ	chr17	80857943	Intron	rs777190073		0.5
SKCM	chr17	80823374	Intron	novel		0.38
SKCM	chr17	80883789	Silent	novel	C553C	0.32
SKCM	chr17	80964308	Missense_Mutation	NA	S1329L	0.42
SKCM	chr17	80960089	Silent	rs377182714	T1163T	0.35
SKCM	chr17	80960090	Missense_Mutation	novel	G1164S	0.36
SKCM	chr17	80791489	Silent	novel	V290V	0.18
SKCM	chr17	80837995	Missense_Mutation	NA	R404W	0.47
SKCM	chr17	80892866	Missense_Mutation	NA	E747K	0.43
SKCM	chr17	80823240	Intron	novel		0.17
SKCM	chr17	80545508	5'UTR	novel		0.83
SKCM	chr17	80754130	Missense_Mutation	NA	P259S	0.31
SKCM	chr17	80962556	Missense_Mutation	NA	P1263L	0.33
SKCM	chr17	80962557	Silent	novel	P1263P	0.33
SKCM	chr17	80857833	Missense_Mutation	novel	Q481R	0.26
SKCM	chr17	80962505	Missense_Mutation	novel	S1246L	0.38
SKCM	chr17	80957667	Silent	NA	L1138L	0.1
SKCM	chr17	80925417	Silent	rs772283529	S952S	0.46
SKCM	chr17	80893858	Silent	rs201009704	S798S	0.4
SKCM	chr17	80945716	Silent	NA	V1025V	0.77
SKCM	chr17	80947239	Nonsense_Mutation	NA	W1051*	0.21
SKCM	chr17	80822294	Silent	NA	L328L	0.85
SKCM	chr17	80957621	Splice_Region	novel		0.51
SKCM	chr17	80885075	Missense_Mutation	NA	S637F	0.57
SKCM	chr17	80923536	Missense_Mutation	rs757484259	D891N	0.43
SKCM	chr17	80923536	Missense_Mutation	rs757484259	D891N	0.33
SKCM	chr17	80730642	Missense_Mutation	NA	S197F	0.35
SKCM	chr17	80945765	Missense_Mutation	NA	D1042N	0.5
SKCM	chr17	80923496	Silent	NA	S877S	0.1
SKCM	chr17	80893723	Silent	rs774121223	A753A	0.36
SKCM	chr17	80957665	Missense_Mutation	NA	L1138F	0.6
SKCM	chr17	80964308	Missense_Mutation	NA	S1329L	0.11
SKCM	chr17	80846544	Silent	novel	N428N	0.45
SKCM	chr17	80846545	Missense_Mutation	NA	P429S	0.45
SKCM	chr17	80846479	Missense_Mutation	NA	P407S	0.46
SKCM	chr17	80857791	Missense_Mutation	novel	A467D	0.39
SKCM	chr17	80822299	Missense_Mutation	rs201102317	R330Q	0.18
SKCM	chr17	80893849	Silent	rs552033289	S795S	0.18
SKCM	chr17	80846545	Missense_Mutation	NA	P429S	0.43
SKCM	chr17	80945716	Silent	NA	V1025V	0.41
SKCM	chr17	80945717	Missense_Mutation	novel	P1026S	0.39
SKCM	chr17	80625792	Splice_Region	rs142199743	I88I	0.57
SKCM	chr17	80857922	Intron	novel		0.44
STAD	chr17	80625746	Missense_Mutation	NA	P73H	0.09
STAD	chr17	80625717	Silent	NA	V63V	0.08
STAD	chr17	80908853	Missense_Mutation	NA	L815P	0.21
STAD	chr17	80891736	Missense_Mutation	NA	L667P	0.12
STAD	chr17	80883913	Missense_Mutation	rs775264665	G595S	0.37
STAD	chr17	80754132	Silent	rs138893220	P259P	0.33
STAD	chr17	80892871	Splice_Site	novel	X748_splice	0.25
STAD	chr17	80823135	Missense_Mutation	NA	F350V	0.08
STAD	chr17	80891767	Frame_Shift_Del	novel	*F678Sfs9**	0.08
STAD	chr17	80730681	Missense_Mutation	rs745951041	A210V	0.39
STAD	chr17	80822281	Missense_Mutation	rs748079762	A324V	0.35
STAD	chr17	80822281	Missense_Mutation	rs748079762	A324V	0.23
STAD	chr17	80960173	Silent	rs532712262	R1191R	0.14
STAD	chr17	80880464	Missense_Mutation	NA	S520L	0.14
STAD	chr17	80891756	Missense_Mutation	rs768927275	Y674H	0.3
STAD	chr17	80908849	Missense_Mutation	NA	V814F	0.13
STAD	chr17	80964331	3'UTR	rs773053869		0.38
STAD	chr17	80754178	Missense_Mutation	NA	L275M	0.22
STAD	chr17	80923501	Missense_Mutation	NA	P879L	0.21
STAD	chr17	80885066	Missense_Mutation	novel	T634M	0.5
STAD	chr17	80730568	Silent	rs747545472	T172T	0.06
STAD	chr17	80964309	Silent	rs769703866	S1329S	0.56
STAD	chr17	80891795	Nonsense_Mutation	NA	E687*	0.05
STAD	chr17	80964400	3'UTR	rs540495165		0.53
STAD	chr17	80960161	Silent	rs565225948	D1187D	0.24
STAD	chr17	80730680	Missense_Mutation	rs560409938	A210T	0.17
STAD	chr17	80855506	Missense_Mutation	novel	L453F	0.29
STAD	chr17	80962563	Silent	rs777256656	A1265A	0.38
STAD	chr17	80925441	Silent	rs772995479	C960C	0.18
STAD	chr17	80883871	Missense_Mutation	NA	L581F	0.2
STAD	chr17	80893714	Silent	rs115028103	G750G	0.25
THCA	chr17	80823178	Missense_Mutation	novel	P364L	0.38
UCEC	chr17	80707905	Missense_Mutation	novel	R138H	0.2
UCEC	chr17	80837949	Silent	NA	I388I	0.37
UCEC	chr17	80545701	Nonsense_Mutation	novel	W24*	0.48
UCEC	chr17	80708000	Splice_Site	novel	X169_splice	0.22
UCEC	chr17	80823163	Missense_Mutation	NA	S359L	0.31
UCEC	chr17	80837927	Missense_Mutation	novel	A381V	0.29
UCEC	chr17	80923571	Silent	novel	P902P	0.42
UCEC	chr17	80823163	Missense_Mutation	NA	S359L	0.41
UCEC	chr17	80883451	Silent	rs775568563	L539L	0.46
UCEC	chr17	80947318	Missense_Mutation	rs371494149	G1078S	0.24
UCEC	chr17	80823119	Silent	NA	A344A	0.54
UCEC	chr17	80964447	3'UTR	novel		0.64
UCEC	chr17	80545514	5'UTR	novel		0.28
UCEC	chr17	80949508	Missense_Mutation	novel	A1111T	0.5
UCEC	chr17	80823130	Missense_Mutation	NA	R348Q	0.31
UCEC	chr17	80754127	Missense_Mutation	NA	L258I	0.27
UCEC	chr17	80823241	Intron	novel		0.15
UCEC	chr17	80940581	Missense_Mutation	NA	A1002V	0.3
UCEC	chr17	80945711	Missense_Mutation	rs757342290	G1024S	0.09
UCEC	chr17	80823333	Intron	novel		0.54
UCEC	chr17	80823205	Missense_Mutation	novel	T373M	0.05
UCEC	chr17	80964285	Silent	rs150066910	N1321N	0.51
UCEC	chr17	80823191	Silent	rs112412097	P368P	0.32
UCEC	chr17	80823130	Missense_Mutation	NA	R348Q	0.48
UCEC	chr17	80822279	Silent	novel	I323I	0.45
UCEC	chr17	80593299	Intron	novel		0.17
UCEC	chr17	80707912	Silent	rs752965026	N140N	0.49
UCEC	chr17	80823120	Missense_Mutation	novel	S345G	0.37
UCEC	chr17	80885013	Silent	novel	R616R	0.15
UCEC	chr17	80593249	Intron	novel		0.32
UCEC	chr17	80922773	Missense_Mutation	novel	T857M	0.17
UCEC	chr17	80923599	Missense_Mutation	rs144539543	A912T	0.42
UCEC	chr17	80925374	Missense_Mutation	rs199756138	A938V	0.43
UCEC	chr17	80947289	Missense_Mutation	novel	T1068M	0.42
UCEC	chr17	80893787	Nonsense_Mutation	novel	E775*	0.13
UCEC	chr17	80545628	5'UTR	novel		0.38
UCEC	chr17	80707926	Missense_Mutation	novel	R145Q	0.32
UCEC	chr17	80923655	Silent	rs768543269	F930F	0.43
UCEC	chr17	80545533	5'UTR	novel		0.31
UCEC	chr17	80892753	Missense_Mutation	rs145440027	R709Q	0.2
UCEC	chr17	80545714	Missense_Mutation	novel	A29T	0.42
UCEC	chr17	80823215	Silent	novel	H376H	0.59
UCEC	chr17	80544919	5'Flank	novel		0.25
UCEC	chr17	80707998	Missense_Mutation	novel	K169T	0.54
UCEC	chr17	80837949	Silent	NA	I388I	0.4
UCEC	chr17	80837949	Silent	NA	I388I	0.36
UCEC	chr17	80964499	3'UTR	novel		0.37
UCEC	chr17	80823118	Missense_Mutation	novel	A344V	0.11
UCEC	chr17	80643812	Splice_Site	NA	X116_splice	0.13
UCEC	chr17	80730636	Missense_Mutation	novel	D195V	0.28
UCEC	chr17	80822221	Missense_Mutation	novel	D304G	0.27
UCEC	chr17	80885090	Missense_Mutation	rs141852316	H642R	0.35
UCEC	chr17	80892763	Frame_Shift_Del	novel	*C713Afs8**	0.39
UCEC	chr17	80945709	Missense_Mutation	rs764249284	P1023L	0.37
UCEC	chr17	80823201	Missense_Mutation	novel	P372S	0.15
UCEC	chr17	80730615	Missense_Mutation	NA	S188N	0.39
UCEC	chr17	80545678	Missense_Mutation	novel	D17Y	0.23
UCEC	chr17	80957686	Missense_Mutation	NA	R1145W	0.32
UCEC	chr17	80545026	5'Flank	novel		0.41
UCEC	chr17	80892814	Silent	novel	V729V	0.17
UCEC	chr17	80857986	Intron	novel		0.18
UCEC	chr17	80857961	Intron	novel		0.31
UCEC	chr17	80846503	Missense_Mutation	rs763716081	A415T	0.47
UCEC	chr17	80754093	Silent	rs770049560	C246C	0.13
UCEC	chr17	80625765	Silent	rs142696864	T79T	0.29
UCEC	chr17	80883802	Missense_Mutation	novel	L558I	0.23
UCEC	chr17	80883942	Silent	novel	L604L	0.27
UCEC	chr17	80957656	Missense_Mutation	novel	T1135A	0.33
UCEC	chr17	80964434	3'UTR	novel		0.5
UCEC	chr17	80957686	Missense_Mutation	NA	R1145W	0.16
UCEC	chr17	80960162	Missense_Mutation	novel	G1188S	0.05
UCEC	chr17	80925376	Missense_Mutation	novel	D939Y	0.17
UCEC	chr17	80883438	Missense_Mutation	novel	T535M	0.39
UCEC	chr17	80961461	Missense_Mutation	novel	G1225C	0.36
UCEC	chr17	80730679	Silent	rs747825955	F209F	0.44
UCEC	chr17	80823129	Nonsense_Mutation	NA	R348*	0.36
UCEC	chr17	80545520	5'UTR	novel		0.55
UCEC	chr17	80754131	Missense_Mutation	novel	P259L	0.26
UCEC	chr17	80823178	Missense_Mutation	novel	P364L	0.2
UCEC	chr17	80857853	Missense_Mutation	rs758599889	R488W	0.62
UCEC	chr17	80883836	Missense_Mutation	novel	P569L	0.33
UCEC	chr17	80960161	Silent	rs565225948	D1187D	0.39
UCEC	chr17	80754015	Silent	novel	A220A	0.37
UCEC	chr17	80885092	Missense_Mutation	novel	N643D	0.4
UCEC	chr17	80823092	Missense_Mutation	NA	K335N	0.13
UCEC	chr17	80949452	Missense_Mutation	novel	A1092V	0.1
UCEC	chr17	80730658	Silent	rs751301732	I202I	0.31
UCEC	chr17	80545600	5'UTR	novel		0.42
UCEC	chr17	80893722	Missense_Mutation	rs770546124	A753V	0.43

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	AMP	0.3897	0.00012456
KIRP	AMP	0.6701	0.14801
LGG	AMP	0.0643	1.52e-05
SARC	AMP	0.2296	0.032181
SKCM	AMP	0.2861	7.0388e-08
THCA	DEL	0.004	0.221
UVM	AMP	0.1625	0.054583

Survival Analysis

Cancer	P-value	Q-value
ACC	0.0011	Kaplan-Meier Survival Analysis
SKCM	0.0031	Kaplan-Meier Survival Analysis
LUSC	0.036	Kaplan-Meier Survival Analysis
PAAD	0.0034	Kaplan-Meier Survival Analysis
BLCA	0.016	Kaplan-Meier Survival Analysis
LAML	0.014	Kaplan-Meier Survival Analysis
KICH	0.05	Kaplan-Meier Survival Analysis
LIHC	0.021	Kaplan-Meier Survival Analysis
LUAD	0.036	Kaplan-Meier Survival Analysis

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000141564 (Gene tree)
Gene ID: 57521
Gene Symbol: RPTOR
Alias: KOG1|Mip1|KIAA1303|raptor
Full Name: regulatory associated protein of MTOR complex 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 421,555 bases
Position: chr17:80,544,819-80,966,373
Accession: 30287
RBP type: non-canonical RBP
Summary: This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
17510057	PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding.	J Biol Chem	2007 Jul 6	Wang L	-
17329400	ASCT2 silencing regulates mammalian target-of-rapamycin growth and survival signaling in human hepatoma cells.	Am J Physiol Cell Physiol	2007 Jul	Fuchs BC	-
30942461	Identification of suitable reference genes for gene expression studies in rat skeletal muscle following sciatic nerve crush injury.	Mol Med Rep	2019 May	Wang X	doi: 10.3892/mmr.2019.10102

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000544334	RPTOR-202	5734	-	ENSP00000442479	1177 (aa)	-	Q8N122
ENST00000306801	RPTOR-201	6408	-	ENSP00000307272	1335 (aa)	-	Q8N122
ENST00000575542	RPTOR-209	5536	-	-	- (aa)	-	-
ENST00000574767	RPTOR-208	2461	-	ENSP00000459701	95 (aa)	-	I3L2I3
ENST00000649732	RPTOR-212	2499	-	-	- (aa)	-	-
ENST00000577161	RPTOR-211	3633	-	-	- (aa)	-	-
ENST00000572733	RPTOR-204	424	-	-	- (aa)	-	-
ENST00000573746	RPTOR-206	688	-	-	- (aa)	-	-
ENST00000570891	RPTOR-203	2286	-	ENSP00000460136	379 (aa)	-	Q8N122
ENST00000573163	RPTOR-205	501	-	-	- (aa)	-	-
ENST00000573837	RPTOR-207	443	-	-	- (aa)	-	-
ENST00000576366	RPTOR-210	787	-	ENSP00000460940	235 (aa)	-	I3L436

Gene Model

Click here to download ENSG00000141564's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04136	Autophagy - other	KEGG
hsa04140	Autophagy - animal	KEGG
hsa04150	mTOR signaling pathway	KEGG
hsa04151	PI3K-Akt signaling pathway	KEGG
hsa04152	AMPK signaling pathway	KEGG
hsa04211	Longevity regulating pathway	KEGG
hsa04213	Longevity regulating pathway - multiple species	KEGG
hsa04714	Thermogenesis	KEGG
hsa04910	Insulin signaling pathway	KEGG
hsa05206	MicroRNAs in cancer	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000141564	Blood Pressure	3.0510000E-005	-
ENSG00000141564	Blood Pressure	9.4100000E-005	-
ENSG00000141564	Blood Pressure	1.2750000E-005	-
ENSG00000141564	Blood Pressure	7.9020000E-005	-
ENSG00000141564	Blood Pressure	8.9430000E-005	-
ENSG00000141564	Blood Pressure	6.9960000E-005	-
ENSG00000141564	Platelet Function Tests	2.2304700E-005	-
ENSG00000141564	Platelet Function Tests	1.3048300E-005	-
ENSG00000141564	Platelet Function Tests	2.8965900E-005	-
ENSG00000141564	Platelet Function Tests	3.1423611E-006	-
ENSG00000141564	Platelet Function Tests	4.1482005E-006	-
ENSG00000141564	Platelet Function Tests	2.6898337E-006	-
ENSG00000141564	Platelet Function Tests	1.6369963E-006	-
ENSG00000141564	Platelet Function Tests	7.5636642E-007	-
ENSG00000141564	Schizophrenia	7E-6	26198764
ENSG00000141564	Bronchial Provocation Tests	9E-6	25514360
ENSG00000141564	Pulmonary Disease, Chronic Obstructive	9E-6	25514360
ENSG00000141564	Body Mass Index	5E-7	25673413
ENSG00000141564	Body Mass Index	2E-9	25673413
ENSG00000141564	Myopia, Degenerative	2E-6	23049088
ENSG00000141564	Body Mass Index	4E-10	25673413
ENSG00000141564	Obesity	2E-8	23563607

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000141564	rs4969427	17	80789086	A	Cognitive empathy	28584286	[0.09-0.222] unit decrease	0.1559	EFO_0009183
ENSG00000141564	rs139293840	17	80556559	?	Pulse pressure	29403010	[0.074-0.141] unit increase	0.1079	EFO_0005763
ENSG00000141564	rs8066384	17	80651956	C	Schizophrenia	26198764	[NR]	1.0526316	EFO_0000692
ENSG00000141564	rs7215564	17	80763487	?	Myopia (pathological)	23049088	[NR]		EFO_0004207
ENSG00000141564	rs7503807	17	80617311	A	Obesity	23563607	[NR]	1.04	EFO_0001073
ENSG00000141564	rs12940622	17	80641771	A	Body mass index	28892062	[0.01-0.018] kg/m2 decrease	0.014	EFO_0004340
ENSG00000141564	rs4969426	17	80789008	T	Moyamoya disease	29273593	[NR]	1.43	Orphanet_2573
ENSG00000141564	rs1045626	17	80966164	T	Educational attainment (MTAG)	30038396	[0.0051-0.0101] unit increase	0.0076	EFO_0004784
ENSG00000141564	rs62069681	17	80650902	C	Blood protein levels	29875488	[0.43-0.59] unit increase	0.51	EFO_0007937
ENSG00000141564	rs2672886	17	80807851	C	Airway responsiveness in chronic obstructive pulmonary disease	25514360	[NR] unit increase	0.051	EFO_0006897\|EFO_0000341
ENSG00000141564	rs12940622	17	80641771	A	BMI (adjusted for smoking behaviour)	28443625	[0.014-0.032] kg/m2 decrease	0.0232	EFO_0004318\|EFO_0004340
ENSG00000141564	rs12940622	17	80641771	A	BMI (adjusted for smoking behaviour)	28443625	[0.012-0.024] kg/m2 decrease	0.0178	EFO_0004318\|EFO_0004340
ENSG00000141564	rs12940622	17	80641771	A	Body mass index (joint analysis main effects and smoking interaction)	28443625			EFO_0004318\|EFO_0004340
ENSG00000141564	rs12940622	17	80641771	A	Body mass index (joint analysis main effects and smoking interaction)	28443625			EFO_0004318\|EFO_0004340
ENSG00000141564	rs12940622	17	80641771	A	BMI in non-smokers	28443625	[0.015-0.036] kg/m2 decrease	0.0258	EFO_0004340
ENSG00000141564	rs12940622	17	80641771	A	BMI in non-smokers	28443625	[0.011-0.025] kg/m2 decrease	0.0182	EFO_0004340
ENSG00000141564	rs12939549	17	80637924	A	Body mass index	26426971	unit increase	0.017547995	EFO_0004340
ENSG00000141564	rs12939549	17	80637924	A	Body mass index	30108127	[NR] unit increase	0.017	EFO_0004340
ENSG00000141564	rs58418838	17	80727155	?	Menarche (age at onset)	30595370			EFO_0004703
ENSG00000141564	rs11150745	17	80783826	?	Body mass index	30595370			EFO_0004340
ENSG00000141564	rs10438820	17	80550797	T	Alcohol consumption (drinks per week) (MTAG)	30643251	[0.0057-0.0113] unit increase	0.00850176	EFO_0007878
ENSG00000141564	rs10438820	17	80550797	T	Alcohol consumption (drinks per week)	30643251	[0.0058-0.0121] unit increase	0.008971778	EFO_0007878

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000141564's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001030	RNA polymerase III type 1 promoter DNA binding	20233713.	IDA	Function
GO:0001031	RNA polymerase III type 2 promoter DNA binding	20233713.	IDA	Function
GO:0001032	RNA polymerase III type 3 promoter DNA binding	20233713.	IDA	Function
GO:0001156	TFIIIC-class transcription factor complex binding	20543138.	IDA	Function
GO:0001558	regulation of cell growth	20381137.	IMP	Process
GO:0001938	positive regulation of endothelial cell proliferation	-	IEA	Process
GO:0005515	protein binding	12150925.12150926.12408816.17386266.17461779.17565979.18337751.18955708.19446321.19619545.19875983.20347422.20543138.20562859.21045808.21339740.21471201.21614075.22424946.23027611.23263282.23953116.24036451.24375676.25446900.25561175.25567906.25657994.25686248.25940091.26348909.26678875.26787466.27043084.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	20381137.	IDA	Component
GO:0005764	lysosome	20381137.	IDA	Component
GO:0005764	lysosome	22424946.	IMP	Component
GO:0005765	lysosomal membrane	17897319.	HDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0007050	cell cycle arrest	-	TAS	Process
GO:0008361	regulation of cell size	21873635.	IBA	Process
GO:0008361	regulation of cell size	12150925.	IMP	Process
GO:0009267	cellular response to starvation	21873635.	IBA	Process
GO:0010494	cytoplasmic stress granule	25940091.	IDA	Component
GO:0010800	positive regulation of peptidyl-threonine phosphorylation	18426977.	IMP	Process
GO:0016032	viral process	-	IEA	Process
GO:0016241	regulation of macroautophagy	-	TAS	Process
GO:0019901	protein kinase binding	18439900.	IPI	Function
GO:0030291	protein serine/threonine kinase inhibitor activity	12718876.	IDA	Function
GO:0030295	protein kinase activator activity	12150926.	IDA	Function
GO:0030307	positive regulation of cell growth	21873635.	IBA	Process
GO:0030307	positive regulation of cell growth	18426977.	IMP	Process
GO:0030425	dendrite	-	IEA	Component
GO:0030674	protein binding, bridging	21873635.	IBA	Function
GO:0030674	protein binding, bridging	12150926.	IDA	Function
GO:0031669	cellular response to nutrient levels	12150925.	IMP	Process
GO:0031929	TOR signaling	21873635.	IBA	Process
GO:0031929	TOR signaling	20381137.	IDA	Process
GO:0031931	TORC1 complex	21873635.	IBA	Component
GO:0031931	TORC1 complex	12150926.12718876.15467718.24036451.25940091.	IDA	Component
GO:0032008	positive regulation of TOR signaling	12150926.18439900.	IDA	Process
GO:0032147	activation of protein kinase activity	-	IEA	Process
GO:0033138	positive regulation of peptidyl-serine phosphorylation	18426977.	IMP	Process
GO:0038202	TORC1 signaling	12718876.	IMP	Process
GO:0043025	neuronal cell body	-	IEA	Component
GO:0044877	protein-containing complex binding	19211835.	IPI	Function
GO:0045945	positive regulation of transcription by RNA polymerase III	20233713.	IMP	Process
GO:0071230	cellular response to amino acid stimulus	21873635.	IBA	Process
GO:0071230	cellular response to amino acid stimulus	20381137.	IMP	Process
GO:0071233	cellular response to leucine	22424946.	IDA	Process
GO:0071889	14-3-3 protein binding	18439900.	IDA	Function
GO:0071901	negative regulation of protein serine/threonine kinase activity	-	IEA	Process
GO:0071902	positive regulation of protein serine/threonine kinase activity	21873635.	IBA	Process
GO:0071902	positive regulation of protein serine/threonine kinase activity	12150926.	IDA	Process
GO:1900034	regulation of cellular response to heat	-	TAS	Process
GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	18426977.	IMP	Process

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.