EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26707881	Inhibition of BRD4 suppresses tumor growth and enhances iodine uptake in thyroid cancer.	Biochem Biophys Res Commun	2016 Jan 15	Gao X	doi: 10.1016/j.bbrc.2015.12.008
25284786	Transformation resistance in a premature aging disorder identifies a tumor-protective function of BRD4.	Cell Rep	2014 Oct 9	Fernandez P	doi: 10.1016/j.celrep.2014.08.069
28073847	Identification of CCR2 and CD180 as Robust Pharmacodynamic Tumor and Blood Biomarkers for Clinical Use with BRD4/BET Inhibitors.	Clin Cancer Res	2017 Feb 15	Yeh TC	doi: 10.1158/1078-0432.CCR-16-1658
26752646	CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer.	J Clin Invest	2016 Feb	McCleland ML	doi: 10.1172/JCI83265
24646477	Selective inhibition of BET bromodomain epigenetic signalling interferes with the bone-associated tumour vicious cycle.	Nat Commun	2014 Mar 19	Lamoureux F	doi: 10.1038/ncomms4511.
25647019	BRD4 promotes pancreatic ductal adenocarcinoma cell proliferation and enhances gemcitabine resistance.	Oncol Rep	2015 Apr	Wang YH	doi: 10.3892/or.2015.3774
27099234	BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance.	Cancer Discov	2016 Jun	Tasdemir N	doi: 10.1158/2159-8290.CD-16-0217
28100396	Small molecules remain on target for c-Myc.	Elife	2017 Jan 19	Sun L	doi: 10.7554/eLife.22915.
27440272	Bromodomain and Extraterminal Protein Inhibitor JQ1 Suppresses Thyroid Tumor Growth in a Mouse Model.	Clin Cancer Res	2017 Jan 15	Zhu X	doi: 10.1158/1078-0432.CCR-16-0914
30308518	Bromodomain-Containing Protein 4 (BRD4) Inhibition Sensitizes Palomid 529-Induced Anti-Renal Cell Carcinoma Cell Activity in Vitro and in Vivo.	Cell Physiol Biochem	2018	Xing ZY	doi: 10.1159/000494185
26840017	High level of BRD4 promotes non-small cell lung cancer progression.	Oncotarget	2016 Feb 23	Liao YF	doi: 10.18632/oncotarget.7068.
27769352	Phospho-BRD4: transcription plasticity and drug targeting.	Drug Discov Today Technol	2016 Mar	Chiang CM	doi: 10.1016/j.ddtec.2016.05.003
28681984	BRD4 promotes gastric cancer progression through the transcriptional and epigenetic regulation of c-MYC.	J Cell Biochem	2018 Jan	Ba M	doi: 10.1002/jcb.26264
30036377	BRD4 amplification facilitates an oncogenic gene expression program in high-grade serous ovarian cancer and confers sensitivity to BET inhibitors.	PLoS One	2018 Jul 23	Rhyasen GW	doi: 10.1371/journal.pone.0200826
24525235	Disrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancer.	Cancer Cell	2014 Feb 10	Shi J	doi: 10.1016/j.ccr.2014.01.028.
26626481	NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler.	Mol Cell	2015 Dec 17	Shen C	doi: 10.1016/j.molcel.2015.10.033
22120039	Aberrant epigenetic regulation of bromodomain BRD4 in human colon cancer.	J Mol Med (Berl)	2012 May	Rodriguez RM	doi: 10.1007/s00109-011-0837-0
19846528	Abrogation of the Brd4-positive transcription elongation factor B complex by papillomavirus E2 protein contributes to viral oncogene repression.	J Virol	2010 Jan	Yan J	doi: 10.1128/JVI.01647-09.
25892415	Histo-genomic stratification reveals the frequent amplification/overexpression of CCNE1 and BRD4 genes in non-BRCAness high grade ovarian carcinoma.	Int J Cancer	2015 Oct 15	Goundiam O	doi: 10.1002/ijc.29568
25506891	Twist-BRD4 complex: potential drug target for basal-like breast cancer.	Curr Pharm Des	2015	Shi J	-
27084101	BET Inhibition Attenuates Helicobacter pylori-Induced Inflammatory Response by Suppressing Inflammatory Gene Transcription and Enhancer Activation.	J Immunol	2016 May 15	Chen J	doi: 10.4049/jimmunol.1502261
29133261	Dual inhibition of BRD4 and PI3K by SF2523 suppresses human prostate cancer cell growth invitro and invivo.	Biochem Biophys Res Commun	2018 Jan 1	Shen G	doi: 10.1016/j.bbrc.2017.11.062
27259267	BET inhibition as a new strategy for the treatment of gastric cancer.	Oncotarget	2016 Jul 12	Montenegro RC	doi: 10.18632/oncotarget.9766.
28766687	Downregulation of BRD4 inhibits gallbladder cancer proliferation and metastasis and induces apoptosis via PI3K/AKT pathway.	Int J Oncol	2017 Sep	Hao J	doi: 10.3892/ijo.2017.4081
30029633	Tumoral BRD4 expression in lymph node-negative breast cancer: association with T-bet+ tumor-infiltrating lymphocytes and disease-free survival.	BMC Cancer	2018 Jul 20	Lee M	doi: 10.1186/s12885-018-4653-6.
30272279	Inhibition of BRD4 suppresses tumor growth in prostate cancer via the enhancement of FOXO1 expression.	Int J Oncol	2018 Dec	Tan Y	doi: 10.3892/ijo.2018.4577
30057199	DUB3 Promotes BET Inhibitor Resistance and Cancer Progression by Deubiquitinating BRD4.	Mol Cell	2018 Aug 16	Jin X	doi: 10.1016/j.molcel.2018.06.036

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr19	15244728	Silent	rs201923211	P731P	0.34
BLCA	chr19	15239088	Silent	novel	E1251E	0.24
BLCA	chr19	15268961	Missense_Mutation	novel	Q123E	0.18
BLCA	chr19	15244752	Silent	rs758698520	P723P	0.16
BLCA	chr19	15243329	Missense_Mutation	novel	E914K	0.24
BLCA	chr19	15255550	Silent	rs201603972	T598T	0.24
BLCA	chr19	15239129	Missense_Mutation	NA	E1238K	0.5
BLCA	chr19	15265595	Missense_Mutation	novel	S203L	0.44
BLCA	chr19	15265594	Silent	novel	S203S	0.36
BLCA	chr19	15256152	Nonsense_Mutation	novel	E555*	0.15
BLCA	chr19	15239421	Missense_Mutation	novel	E1183K	0.57
BLCA	chr19	15253736	Intron	novel		0.58
BLCA	chr19	15257005	Missense_Mutation	NA	E504K	0.5
BLCA	chr19	15244362	Missense_Mutation	novel	F817C	0.14
BLCA	chr19	15243412	Missense_Mutation	rs758977685	R886Q	0.43
BLCA	chr19	15264578	Missense_Mutation	novel	K346N	0.42
BLCA	chr19	15239767	Missense_Mutation	novel	E1113K	0.17
BLCA	chr19	15256248	Missense_Mutation	novel	E523K	0.22
BRCA	chr19	15256100	Frame_Shift_Del	NA	*K572Rfs12**	0.24
BRCA	chr19	15265411	Silent	novel	A264A	1
BRCA	chr19	15256100	Frame_Shift_Del	NA	*K572Rfs12**	0.06
BRCA	chr19	15256177	Missense_Mutation	rs761158744	K546N	0.16
BRCA	chr19	15247283	Intron	novel		0.47
BRCA	chr19	15273056	Missense_Mutation	rs369254108	P15L	0.07
BRCA	chr19	15238233	3'UTR	novel		0.58
BRCA	chr19	15244752	Silent	rs758698520	P723P	0.13
BRCA	chr19	15264730	Missense_Mutation	novel	T296P	0.39
BRCA	chr19	15239973	Missense_Mutation	NA	M1073I	0.28
CESC	chr19	15264473	Silent	rs201519292	D381D	0.17
CESC	chr19	15239074	Missense_Mutation	novel	R1256Q	0.33
CESC	chr19	15268941	Missense_Mutation	NA	F129L	0.34
CESC	chr19	15257113	Missense_Mutation	rs201081104	V468M	0.12
CESC	chr19	15239074	Missense_Mutation	novel	R1256Q	0.36
CESC	chr19	15239951	Missense_Mutation	novel	H1081N	0.08
CESC	chr19	15268918	Missense_Mutation	novel	Y137C	0.44
CESC	chr19	15239168	Missense_Mutation	rs745807590	E1225K	0.13
CESC	chr19	15238425	Missense_Mutation	novel	M1347I	0.67
COAD	chr19	15238257	3'UTR	novel		0.4
COAD	chr19	15239065	Missense_Mutation	NA	R1259H	0.25
COAD	chr19	15238311	3'UTR	rs201672958		0.25
COAD	chr19	15244316	Missense_Mutation	NA	Q832H	0.15
COAD	chr19	15265578	Missense_Mutation	rs201864530	Q209E	0.17
COAD	chr19	15256240	Silent	novel	L525L	0.29
COAD	chr19	15256097	Missense_Mutation	rs150583855	T573M	0.04
COAD	chr19	15239402	Missense_Mutation	rs368540009	A1189V	0.28
COAD	chr19	15263494	Nonsense_Mutation	NA	R423*	0.38
COAD	chr19	15238778	Missense_Mutation	novel	R1329W	0.47
COAD	chr19	15255450	Missense_Mutation	NA	R632C	0.23
COAD	chr19	15239155	Missense_Mutation	novel	R1229H	0.31
COAD	chr19	15239742	Missense_Mutation	novel	R1121H	0.27
COAD	chr19	15244366	Missense_Mutation	rs760576705	V816I	0.3
COAD	chr19	15256239	Missense_Mutation	novel	A526T	0.38
COAD	chr19	15255387	Nonsense_Mutation	NA	E653*	0.13
COAD	chr19	15273044	Missense_Mutation	novel	D19G	0.08
COAD	chr19	15256231	Silent	NA	L528L	0.21
COAD	chr19	15239212	Missense_Mutation	NA	P1210L	0.19
COAD	chr19	15265627	Silent	rs763875252	G192G	0.27
COAD	chr19	15257053	Missense_Mutation	novel	S488G	0.26
COAD	chr19	15257165	Silent	rs201699426	F450F	0.43
COAD	chr19	15243034	Missense_Mutation	rs749938247	P1012L	0.1
COAD	chr19	15272834	Missense_Mutation	NA	A89V	0.35
COAD	chr19	15257165	Silent	rs201699426	F450F	0.2
COAD	chr19	15256086	Missense_Mutation	NA	N577D	0.34
COAD	chr19	15263494	Nonsense_Mutation	NA	R423*	0.1
COAD	chr19	15264688	Missense_Mutation	NA	P310S	0.04
COAD	chr19	15265388	Missense_Mutation	NA	P272L	0.24
COAD	chr19	15263500	Missense_Mutation	NA	D421H	0.1
DLBC	chr19	15256110	Missense_Mutation	rs201937726	P569S	0.25
ESCA	chr19	15256163	Missense_Mutation	novel	H551R	0.26
ESCA	chr19	15256199	Missense_Mutation	novel	K539R	0.38
ESCA	chr19	15249001	Intron	novel		0.19
ESCA	chr19	15255507	Missense_Mutation	novel	E613K	0.1
ESCA	chr19	15265503	Missense_Mutation	novel	V234I	0.42
ESCA	chr19	15244366	Missense_Mutation	rs760576705	V816I	0.09
ESCA	chr19	15247102	Intron	rs565692731		0.38
ESCA	chr19	15249077	Intron	novel		0.31
GBM	chr19	15256194	Missense_Mutation	novel	K541Q	0.3
GBM	chr19	15244562	Silent	rs141814143	P750P	0.26
GBM	chr19	15272982	Missense_Mutation	rs768982122	A40T	0.39
GBM	chr19	15239222	Missense_Mutation	novel	Q1207E	0.26
GBM	chr19	15239440	Missense_Mutation	novel	D1176E	0.34
GBM	chr19	15263483	Missense_Mutation	NA	F426L	0.08
GBM	chr19	15256080	Missense_Mutation	novel	S579R	0.17
GBM	chr19	15242917	Missense_Mutation	rs202165230	S1051L	0.12
GBM	chr19	15263439	Missense_Mutation	rs779993356	A441V	0.19
GBM	chr19	15268956	Missense_Mutation	novel	E124D	0.45
GBM	chr19	15254180	Missense_Mutation	novel	S710R	0.81
GBM	chr19	15265556	Missense_Mutation	novel	P216H	0.55
GBM	chr19	15239751	Missense_Mutation	novel	P1118L	0.25
GBM	chr19	15263546	Splice_Region	novel	S405S	0.09
GBM	chr19	15265589	Missense_Mutation	novel	P205L	0.22
GBM	chr19	15255422	Missense_Mutation	novel	E641A	0.38
GBM	chr19	15268971	Nonsense_Mutation	novel	Y119*	0.11
GBM	chr19	15272939	Missense_Mutation	novel	N54S	0.11
GBM	chr19	15255550	Silent	novel	T598T	0.04
GBM	chr19	15264542	Missense_Mutation	novel	S358R	0.04
HNSC	chr19	15239804	Silent	rs778881856	S1100S	0.33
HNSC	chr19	15244763	Splice_Site	novel	X720_splice	0.32
HNSC	chr19	15263533	Missense_Mutation	rs200659364	R410C	0.34
HNSC	chr19	15239091	In_Frame_Del	novel	K1250del	0.19
HNSC	chr19	15263521	Missense_Mutation	novel	D414N	0.39
HNSC	chr19	15256261	Splice_Region	novel	L518L	0.18
HNSC	chr19	15263523	Missense_Mutation	rs201883209	R413H	0.11
HNSC	chr19	15239790	Missense_Mutation	novel	Q1105R	0.29
HNSC	chr19	15239732	Silent	novel	P1124P	0.51
HNSC	chr19	15264434	Missense_Mutation	novel	I394M	0.04
HNSC	chr19	15255497	Missense_Mutation	novel	R616Q	0.2
KIRC	chr19	15244350	Frame_Shift_Ins	novel	*G821Efs15**	0.16
KIRP	chr19	15243276	Silent	novel	Y931Y	0.56
KIRP	chr19	15239708	Silent	NA	E1132E	0.4
KIRP	chr19	15240011	Missense_Mutation	rs200902225	E1061K	0.39
LAML	chr19	15264481	Missense_Mutation	novel	P379S	0.07
LAML	chr19	15239701	Frame_Shift_Ins	novel	*K1135Qfs42**	0.45
LAML	chr19	15239997	Silent	novel	P1065P	0.2
LIHC	chr19	15257146	Missense_Mutation	NA	M457L	0.32
LIHC	chr19	15238769	Nonsense_Mutation	NA	E1332*	0.48
LIHC	chr19	15244302	Frame_Shift_Del	novel	*P833Lfs58**	0.29
LIHC	chr19	15244384	Missense_Mutation	novel	P810S	0.37
LIHC	chr19	15265601	Missense_Mutation	NA	Q201P	0.15
LIHC	chr19	15239951	Missense_Mutation	NA	H1081Y	0.4
LIHC	chr19	15249170	Intron	novel		0.5
LIHC	chr19	15249186	Intron	novel		0.09
LIHC	chr19	15239817	Missense_Mutation	novel	L1096P	0.8
LUAD	chr19	15272958	Missense_Mutation	novel	P48A	0.38
LUAD	chr19	15239391	Splice_Site	novel	X1192_splice	0.35
LUAD	chr19	15239392	Missense_Mutation	novel	K1192N	0.34
LUAD	chr19	15243476	Missense_Mutation	NA	A865T	0.33
LUAD	chr19	15257143	Missense_Mutation	NA	P458T	0.89
LUAD	chr19	15249252	Intron	novel		0.16
LUAD	chr19	15249258	Intron	novel		0.14
LUAD	chr19	15249201	Intron	novel		0.38
LUAD	chr19	15256186	Missense_Mutation	NA	K543N	0.24
LUAD	chr19	15257141	Silent	novel	P458P	0.21
LUSC	chr19	15264715	Missense_Mutation	novel	D301N	0.16
LUSC	chr19	15239133	Missense_Mutation	NA	E1236D	0.26
LUSC	chr19	15244729	Missense_Mutation	rs149185763	P731L	0.29
LUSC	chr19	15264416	Missense_Mutation	novel	M400I	0.09
LUSC	chr19	15238374	3'UTR	rs369068599		0.26
LUSC	chr19	15238776	Silent	NA	R1329R	0.1
LUSC	chr19	15239246	Missense_Mutation	novel	M1199L	0.18
LUSC	chr19	15255483	Missense_Mutation	novel	D621H	0.16
LUSC	chr19	15239452	Silent	rs560435464	P1172P	0.09
LUSC	chr19	15240014	Missense_Mutation	rs768141679	R1060C	0.1
LUSC	chr19	15239805	Missense_Mutation	NA	S1100F	0.14
LUSC	chr19	15243266	Silent	NA	L935L	0.78
LUSC	chr19	15249177	Intron	novel		1
LUSC	chr19	15254216	Missense_Mutation	NA	F698L	0.21
LUSC	chr19	15257069	Silent	rs750121394	P482P	0.48
LUSC	chr19	15244712	Missense_Mutation	novel	K737Q	0.27
OV	chr19	15249273	Intron	novel		0.15
OV	chr19	15239403	Missense_Mutation	novel	A1189P	0.13
OV	chr19	15239404	Silent	novel	V1188V	0.12
OV	chr19	15264648	Missense_Mutation	novel	E323G	0.37
OV	chr19	15273116	5'UTR	novel		0.08
OV	chr19	15265618	Silent	NA	T195T	0.56
OV	chr19	15255313	Silent	rs748300253	K677K	0.1
OV	chr19	15268954	Missense_Mutation	NA	C125Y	0.35
OV	chr19	15264746	Silent	novel	R290R	0.21
PAAD	chr19	15273120	5'UTR	novel		0.19
PAAD	chr19	15239178	Silent	NA	S1221S	0.08
PAAD	chr19	15254159	Silent	rs200329089	S717S	0.09
PAAD	chr19	15254239	Missense_Mutation	rs774596084	G691S	0.21
PAAD	chr19	15255358	Silent	novel	S662S	0.05
PAAD	chr19	15264636	Missense_Mutation	novel	P327L	0.04
PAAD	chr19	15273071	Missense_Mutation	novel	R10I	0.12
PRAD	chr19	15242990	Frame_Shift_Ins	novel	*Q1027Sfs66**	0.33
PRAD	chr19	15249126	Intron	novel		0.43
READ	chr19	15255425	Missense_Mutation	NA	R640Q	0.38
READ	chr19	15239995	Missense_Mutation	NA	L1066P	0.4
READ	chr19	15273085	Silent	rs147477529	S5S	0.25
SARC	chr19	15247111	Intron	novel		0.29
SARC	chr19	15257068	Missense_Mutation	novel	P483T	0.1
SARC	chr19	15257114	Silent	rs774896276	A467A	0.4
SARC	chr19	15244425	Missense_Mutation	rs200532628	S796L	0.09
SKCM	chr19	15244746	Silent	NA	S725S	0.08
SKCM	chr19	15255502	Missense_Mutation	novel	E614D	0.06
SKCM	chr19	15239726	Silent	NA	S1126S	0.25
SKCM	chr19	15272964	Missense_Mutation	NA	P46S	0.35
SKCM	chr19	15264562	Missense_Mutation	novel	E352K	0.76
SKCM	chr19	15264563	Silent	rs199831061	S351S	0.75
SKCM	chr19	15238419	Silent	NA	F1349F	0.45
SKCM	chr19	15238947	Silent	NA	A1272A	0.4
SKCM	chr19	15239107	Missense_Mutation	novel	A1245V	0.36
SKCM	chr19	15239785	Missense_Mutation	rs200882606	L1107F	0.09
SKCM	chr19	15265557	Missense_Mutation	rs758207588	P216S	0.28
SKCM	chr19	15238428	Missense_Mutation	NA	D1346E	0.24
SKCM	chr19	15254159	Silent	rs200329089	S717S	0.2
SKCM	chr19	15254160	Missense_Mutation	novel	S717F	0.2
SKCM	chr19	15264710	Silent	NA	P302P	0.17
SKCM	chr19	15265622	Missense_Mutation	NA	S194F	0.27
SKCM	chr19	15272817	Missense_Mutation	NA	P95S	0.21
SKCM	chr19	15257105	Silent	NA	S470S	0.34
SKCM	chr19	15257106	Missense_Mutation	NA	S470F	0.35
SKCM	chr19	15239159	Missense_Mutation	NA	R1228C	0.6
SKCM	chr19	15255322	Missense_Mutation	NA	C674W	0.22
SKCM	chr19	15255559	Silent	NA	P595P	0.4
SKCM	chr19	15255415	Silent	novel	S643S	0.45
SKCM	chr19	15239212	Missense_Mutation	NA	P1210L	0.26
SKCM	chr19	15255399	Missense_Mutation	novel	P649S	0.35
SKCM	chr19	15255400	Silent	novel	N648N	0.34
SKCM	chr19	15273056	Missense_Mutation	rs369254108	P15L	0.21
SKCM	chr19	15267531	Silent	rs748805963	L148L	0.07
SKCM	chr19	15239997	Silent	novel	P1065P	0.22
SKCM	chr19	15239998	Missense_Mutation	novel	P1065R	0.22
SKCM	chr19	15264640	Missense_Mutation	NA	R326W	0.36
SKCM	chr19	15265528	Silent	rs200115372	F225F	0.3
SKCM	chr19	15272964	Missense_Mutation	NA	P46S	0.26
SKCM	chr19	15255530	Missense_Mutation	NA	D605V	0.46
SKCM	chr19	15273067	Missense_Mutation	NA	L11F	0.4
SKCM	chr19	15239675	Silent	rs201578775	P1143P	0.68
SKCM	chr19	15239676	Missense_Mutation	rs759208540	P1143L	0.68
SKCM	chr19	15256110	Missense_Mutation	rs201937726	P569S	0.35
SKCM	chr19	15239196	Silent	novel	S1215S	0.14
SKCM	chr19	15239197	Missense_Mutation	novel	S1215F	0.14
SKCM	chr19	15244425	Missense_Mutation	rs200532628	S796L	0.24
SKCM	chr19	15257106	Missense_Mutation	NA	S470F	0.1
SKCM	chr19	15254193	Missense_Mutation	NA	S706F	0.19
SKCM	chr19	15267492	Silent	rs769496685	I161I	0.41
SKCM	chr19	15243402	Silent	NA	A889A	0.18
SKCM	chr19	15243418	Missense_Mutation	novel	P884L	0.25
SKCM	chr19	15238314	3'UTR	rs187083313		0.47
SKCM	chr19	15264696	Missense_Mutation	rs149454272	P307L	0.19
SKCM	chr19	15264492	Missense_Mutation	NA	P375L	0.3
SKCM	chr19	15253697	Intron	rs761716135		0.17
SKCM	chr19	15239703	Missense_Mutation	novel	P1134L	0.28
SKCM	chr19	15265526	Missense_Mutation	NA	P226L	0.21
STAD	chr19	15253697	Intron	rs761716135		0.24
STAD	chr19	15242930	Missense_Mutation	NA	R1047W	0.28
STAD	chr19	15255465	Missense_Mutation	rs752762666	G627S	0.16
STAD	chr19	15244371	Missense_Mutation	NA	G814D	0.24
STAD	chr19	15272910	Nonsense_Mutation	NA	Q64*	0.22
STAD	chr19	15253719	Intron	rs574180950		0.23
STAD	chr19	15238919	Missense_Mutation	rs750347317	R1282C	0.21
STAD	chr19	15255551	Missense_Mutation	rs138134048	T598M	0.05
STAD	chr19	15253648	Intron	novel		0.44
STAD	chr19	15254213	Silent	rs200566617	S699S	0.19
STAD	chr19	15265618	Silent	rs183675300	T195T	0.4
STAD	chr19	15255359	Missense_Mutation	NA	S662F	0.09
STAD	chr19	15265638	Missense_Mutation	novel	A189T	0.22
STAD	chr19	15265627	Silent	rs763875252	G192G	0.41
STAD	chr19	15243004	Missense_Mutation	rs780028668	P1022L	0.45
STAD	chr19	15256218	Missense_Mutation	NA	Q533K	0.32
STAD	chr19	15253696	Intron	rs199764678		0.39
STAD	chr19	15268998	Silent	NA	I110I	0.12
STAD	chr19	15239132	Missense_Mutation	NA	R1237C	0.38
STAD	chr19	15272962	Silent	rs139655217	P46P	0.21
STAD	chr19	15257069	Silent	rs750121394	P482P	0.25
STAD	chr19	15239402	Missense_Mutation	rs368540009	A1189V	0.11
STAD	chr19	15243359	Missense_Mutation	NA	P904S	0.43
STAD	chr19	15243244	Missense_Mutation	rs765227557	T942M	0.23
STAD	chr19	15249252	Intron	rs752575593		0.17
STAD	chr19	15244320	Missense_Mutation	novel	P831L	0.46
THCA	chr19	15257143	Missense_Mutation	novel	P458S	0.11
THYM	chr19	15239764	Missense_Mutation	novel	K1114E	0.33
UCEC	chr19	15254239	Missense_Mutation	rs774596084	G691S	0.57
UCEC	chr19	15249268	Intron	novel		0.39
UCEC	chr19	15238742	Splice_Site	novel	X1340_splice	0.6
UCEC	chr19	15238385	Missense_Mutation	NA	L1361I	0.31
UCEC	chr19	15239074	Missense_Mutation	novel	R1256Q	0.58
UCEC	chr19	15239815	Missense_Mutation	novel	R1097C	0.38
UCEC	chr19	15264694	Missense_Mutation	novel	S308A	0.2
UCEC	chr19	15244285	Missense_Mutation	novel	P843S	0.22
UCEC	chr19	15254204	Silent	novel	E702E	0.37
UCEC	chr19	15238832	Nonsense_Mutation	novel	Q1311*	0.29
UCEC	chr19	15239248	Missense_Mutation	novel	N1198I	0.29
UCEC	chr19	15255538	Missense_Mutation	novel	E602D	0.3
UCEC	chr19	15273120	5'UTR	novel		0.13
UCEC	chr19	15239066	Missense_Mutation	novel	R1259C	0.28
UCEC	chr19	15248137	Intron	novel		0.26
UCEC	chr19	15238760	Nonsense_Mutation	novel	R1335*	0.44
UCEC	chr19	15239417	Missense_Mutation	rs199833998	P1184L	0.42
UCEC	chr19	15247183	Intron	novel		0.44
UCEC	chr19	15249064	Intron	novel		0.48
UCEC	chr19	15253741	Intron	NA		0.25
UCEC	chr19	15265565	Missense_Mutation	novel	P213L	0.45
UCEC	chr19	15255476	Missense_Mutation	novel	N623S	0.18
UCEC	chr19	15239800	Missense_Mutation	NA	V1102I	0.14
UCEC	chr19	15256108	Silent	NA	P569P	0.42
UCEC	chr19	15242930	Missense_Mutation	NA	R1047W	0.19
UCEC	chr19	15265564	Silent	rs751753874	P213P	0.2
UCEC	chr19	15238311	3'UTR	rs201672958		0.13
UCEC	chr19	15238409	Missense_Mutation	NA	L1353I	0.12
UCEC	chr19	15244272	Missense_Mutation	NA	T847N	0.29
UCEC	chr19	15264752	Silent	novel	V288V	0.42
UCEC	chr19	15265626	Missense_Mutation	rs202093296	V193I	0.09
UCEC	chr19	15273013	Silent	NA	T29T	0.11
UCEC	chr19	15238908	Silent	novel	Q1285Q	0.43
UCEC	chr19	15239486	Missense_Mutation	novel	V1161A	0.3
UCEC	chr19	15247143	Intron	novel		0.52
UCEC	chr19	15254213	Silent	novel	S699S	0.22
UCEC	chr19	15244367	Silent	rs558389129	S815S	0.38
UCEC	chr19	15249221	Intron	novel		0.42
UCEC	chr19	15255447	Missense_Mutation	novel	V633M	0.4
UCEC	chr19	15256097	Missense_Mutation	rs150583855	T573M	0.37
UCEC	chr19	15264509	Silent	rs373235795	H369H	0.46
UCEC	chr19	15257044	Missense_Mutation	NA	D491N	0.14
UCEC	chr19	15238952	Nonsense_Mutation	novel	Q1271*	0.45
UCEC	chr19	15248266	Intron	novel		0.6
UCEC	chr19	15253761	Intron	rs763175328		0.31
UCEC	chr19	15272936	Missense_Mutation	novel	K55T	0.52
UCEC	chr19	15238385	Missense_Mutation	NA	L1361I	0.42
UCEC	chr19	15239464	Silent	rs138397884	N1168N	0.33
UCEC	chr19	15255484	Missense_Mutation	novel	L620F	0.16
UCEC	chr19	15238204	3'UTR	novel		0.07
UCEC	chr19	15255426	Missense_Mutation	NA	R640W	0.35
UCEC	chr19	15257158	Missense_Mutation	rs759001252	R453C	0.32
UCEC	chr19	15257167	Missense_Mutation	novel	F450L	0.29
UCEC	chr19	15257169	Missense_Mutation	novel	V449A	0.29
UCEC	chr19	15264740	Silent	novel	A292A	0.29
UCEC	chr19	15248086	Intron	novel		0.73
UCEC	chr19	15247135	Intron	novel		0.21
UCEC	chr19	15254202	Missense_Mutation	NA	S703L	0.22
UCEC	chr19	15267534	Silent	novel	V147V	0.19
UCEC	chr19	15238442	Missense_Mutation	novel	A1342T	0.39
UCEC	chr19	15254206	Frame_Shift_Ins	novel	*E702Rfs7**	0.19
UCEC	chr19	15264424	Missense_Mutation	novel	M398V	0.43
UCEC	chr19	15244752	Silent	rs758698520	P723P	0.44
UCEC	chr19	15255497	Missense_Mutation	novel	R616Q	0.5
UCEC	chr19	15263459	Silent	novel	P434P	0.07
UCEC	chr19	15238844	Missense_Mutation	rs748234502	A1307T	0.43
UCEC	chr19	15244250	Silent	rs753850850	H854H	0.44
UCEC	chr19	15255382	Silent	NA	I654I	0.43
UCEC	chr19	15264566	Silent	novel	V350V	0.4
UCEC	chr19	15264683	Silent	rs775880214	P311P	0.49
UCEC	chr19	15249189	Intron	novel		0.45
UCEC	chr19	15255382	Silent	NA	I654I	0.28
UCEC	chr19	15265435	Missense_Mutation	novel	Q256H	0.57
UCEC	chr19	15247183	Intron	novel		0.4
UCEC	chr19	15267468	Silent	novel	T169T	0.04
UCEC	chr19	15265411	Silent	novel	A264A	0.17
UCEC	chr19	15253408	Intron	novel		0.29
UCEC	chr19	15238942	Missense_Mutation	novel	R1274Q	0.33
UCEC	chr19	15255352	Silent	novel	L664L	0.43
UCEC	chr19	15265618	Silent	rs183675300	T195T	0.32
UCEC	chr19	15239211	Silent	rs200270814	P1210P	0.39
UCEC	chr19	15238960	Missense_Mutation	rs781555424	A1268V	0.48
UCEC	chr19	15269042	Missense_Mutation	NA	D96N	0.37
UCEC	chr19	15254252	Silent	novel	V686V	0.33
UCEC	chr19	15264692	Silent	novel	S308S	0.19
UCEC	chr19	15268991	Missense_Mutation	novel	R113C	0.19
UCEC	chr19	15273073	Silent	novel	T9T	0.18
UCEC	chr19	15263548	Missense_Mutation	novel	S405P	0.28
UCEC	chr19	15244251	Missense_Mutation	novel	H854R	0.48
UCEC	chr19	15272963	Frame_Shift_Del	novel	*P46Rfs47**	0.49
UCEC	chr19	15238850	Missense_Mutation	novel	A1305T	0.39
UCEC	chr19	15239444	Frame_Shift_Del	novel	*P1175Lfs20**	0.48
UCEC	chr19	15238287	3'UTR	novel		0.31
UCEC	chr19	15239967	Silent	novel	Q1075Q	0.38
UCEC	chr19	15253473	Intron	novel		0.42
UCEC	chr19	15257019	Missense_Mutation	novel	S499L	0.4
UCEC	chr19	15267512	Missense_Mutation	novel	K155Q	0.33
UCEC	chr19	15244307	Silent	novel	L835L	0.38
UCEC	chr19	15253387	Intron	novel		0.3
UCEC	chr19	15257019	Missense_Mutation	novel	S499L	0.33

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	AMP	0.6111	0.036259
LIHC	AMP	0.1622	0.0089034
OV	AMP	0.437	2.4857e-40
READ	DEL	0.0727	0.23023
THCA	DEL	0.012	0.090402
UCEC	AMP	0.1577	1.7289e-12

Survival Analysis

Cancer	P-value	Q-value
THYM	0.04	Kaplan-Meier Survival Analysis
KIRC	0.00073	Kaplan-Meier Survival Analysis
MESO	0.0095	Kaplan-Meier Survival Analysis
ACC	0.00094	Kaplan-Meier Survival Analysis
SKCM	0.0018	Kaplan-Meier Survival Analysis
BRCA	0.0022	Kaplan-Meier Survival Analysis
KIRP	0.00042	Kaplan-Meier Survival Analysis
COAD	0.012	Kaplan-Meier Survival Analysis
KICH	0.041	Kaplan-Meier Survival Analysis
UCEC	0.046	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
UVM	0.031	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000141867 (Gene tree)
Gene ID: 23476
Gene Symbol: BRD4
Alias: HUNKI|MCAP|CAP|HUNK1
Full Name: bromodomain containing 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 97,027 bases
Position: chr19:15,235,519-15,332,545
Accession: 13575
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
25713319	CXCL8 histone H3 acetylation is dysfunctional in airway smooth muscle in asthma: regulation by BET.	Am J Physiol Lung Cell Mol Physiol	2015 May 1	Clifford RL	doi: 10.1152/ajplung.00021.2015
29176719	Structural Mechanism of the Oxygenase JMJD6 Recognition by the Extraterminal (ET) Domain of BRD4.	Sci Rep	2017 Nov 24	Konuma T	doi: 10.1038/s41598-017-16588-8.
16611886	Bromodomain protein 4 mediates the papillomavirus E2 transcriptional activation function.	J Virol	2006 May	Schweiger MR	-
19129460	Papillomavirus E2 proteins and the host BRD4 protein associate with transcriptionally active cellular chromatin.	J Virol	2009 Mar	Jang MK	doi: 10.1128/JVI.02275-08
18223296	The bromodomain protein Brd4 stimulates G1 gene transcription and promotes progression to S phase.	J Biol Chem	2008 Apr 4	Mochizuki K	doi: 10.1074/jbc.M707603200
17626100	Brd4-independent transcriptional repression function of the papillomavirus e2 proteins.	J Virol	2007 Sep	Schweiger MR	-
22645123	Down-regulation of NF-kB transcriptional activity in HIV-associated kidney disease by BRD4 inhibition.	J Biol Chem	2012 Aug 17	Zhang G	doi: 10.1074/jbc.M112.359505
20422051	Single cell analysis of transcriptional activation dynamics.	PLoS One	2010 Apr 21	Rafalska-Metcalf IU	doi: 10.1371/journal.pone.0010272.
27425608	Signal-Dependent Recruitment of BRD4 to Cardiomyocyte Super-Enhancers Is Suppressed by a MicroRNA.	Cell Rep	2016 Aug 2	Stratton MS	doi: 10.1016/j.celrep.2016.06.074
24763052	The bromodomain protein BRD4 regulates the KEAP1/NRF2-dependent oxidative stress response.	Cell Death Dis	2014 Apr 24	Hussong M	doi: 10.1038/cddis.2014.157.
24435446	Highly active combination of BRD4 antagonist and histone deacetylase inhibitor against human acute myelogenous leukemia cells.	Mol Cancer Ther	2014 May	Fiskus W	doi: 10.1158/1535-7163.MCT-13-0770
24144283	Structure-guided design of potent diazobenzene inhibitors for the BET bromodomains.	J Med Chem	2013 Nov 27	Zhang G	doi: 10.1021/jm401334s
23939492	BET acetyl-lysine binding proteins control pathological cardiac hypertrophy.	J Mol Cell Cardiol	2013 Oct	Spiltoir JI	doi: 10.1016/j.yjmcc.2013.07.017
28077651	BRD4 Couples NF-kB/RelA with Airway Inflammation and the IRF-RIG-I Amplification Loop in Respiratory Syncytial Virus Infection.	J Virol	2017 Feb 28	Tian B	doi: 10.1128/JVI.00007-17
28265070	BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice.	Proc Natl Acad Sci U S A	2017 Mar 14	Cheung K	doi: 10.1073/pnas.1615601114
28195723	Drug Discovery Targeting Bromodomain-Containing Protein 4.	J Med Chem	2017 Jun 8	Liu Z	doi: 10.1021/acs.jmedchem.6b01761
25788266	H4K12ac is regulated by estrogen receptor-alpha and is associated with BRD4 function and inducible transcription.	Oncotarget	2015 Mar 30	Nagarajan S	-
28460090	Identification of active miRNA promoters from nuclear run-on RNA sequencing.	Nucleic Acids Res	2017 Jul 27	Liu Q	doi: 10.1093/nar/gkx318.
28955901	Transcription elongation factor Brd4-P-TEFb accelerates intestinal differentiation-associated SLC2A5 gene expression.	Biochem Biophys Rep	2016 Jun 1	Inamochi Y	doi: 10.1016/j.bbrep.2016.05.016
29425494	Crosstalk between the RNA Methylation and Histone-Binding Activities of MePCE Regulates P-TEFb Activation on Chromatin.	Cell Rep	2018 Feb 6	Shelton SB	doi: 10.1016/j.celrep.2018.01.028.
30321559	Mucosal bromodomain-containing protein 4 mediates aeroallergen-induced inflammation and remodeling.	J Allergy Clin Immunol	2019 Apr	Tian B	doi: 10.1016/j.jaci.2018.09.029
31266503	BRD4 bimodal binding at promoters and drug-induced displacement at Pol II pause sites associates with I-BET sensitivity.	Epigenetics Chromatin	2019 Jul 2	Khoueiry P	doi: 10.1186/s13072-019-0286-5.
31311960	Bromodomain inhibitor JQ1 reversibly blocks IFN-γ production.	Sci Rep	2019 Jul 16	Gibbons HR	doi: 10.1038/s41598-019-46516-x.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000602230	BRD4-211	751	-	-	- (aa)	-	-
ENST00000601941	BRD4-210	604	-	ENSP00000471240	105 (aa)	-	M0R0H4
ENST00000630599	BRD4-212	726	-	ENSP00000486621	146 (aa)	-	M0QYW0
ENST00000595926	BRD4-207	582	-	-	- (aa)	-	-
ENST00000263377	BRD4-201	7169	XM_011527854	ENSP00000263377	1362 (aa)	XP_011526156	O60885
ENST00000597315	BRD4-208	892	-	ENSP00000470108	146 (aa)	-	M0QYW0
ENST00000371835	BRD4-203	4624	XM_011527856	ENSP00000360901	722 (aa)	XP_011526158	O60885
ENST00000360016	BRD4-202	3240	-	ENSP00000353112	794 (aa)	-	O60885
ENST00000601071	BRD4-209	430	-	-	- (aa)	-	-
ENST00000594841	BRD4-205	1821	-	ENSP00000470481	572 (aa)	-	M0QZD9
ENST00000594066	BRD4-204	587	-	-	- (aa)	-	-
ENST00000594842	BRD4-206	408	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000141867's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000141867	Transferrin	1.434e-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000141867	rs200124455	19	15242190	TAC	RANTES levels	27989323	[0.23-0.57] SD units increase	0.3978	EFO_0005117
ENSG00000141867	rs62113853	19	15330512	?	Red cell distribution width	30595370			EFO_0005192
ENSG00000141867	rs6512023	19	15326417	?	Lung function (FVC)	30595370			EFO_0004312
ENSG00000141867	rs8104223	19	15252666	G	Systolic blood pressure	30578418	[0.14-0.29] mmHg decrease	0.2141	EFO_0006335

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000141867's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000141867	BRD4	100	99.315	ENSMUSG00000024002	Brd4	100	99.315	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle	18039861.	IMP	Process
GO:0000794	condensed nuclear chromosome	10938129.	IDA	Component
GO:0001134	transcription regulator recruiting activity	24360279.	IMP	Function
GO:0002039	p53 binding	23317504.	IDA	Function
GO:0003682	chromatin binding	20871596.23086925.23317504.	IDA	Function
GO:0005515	protein binding	17023018.17189189.17474147.18305892.19103749.21555454.22645123.22761572.23455924.23686307.24360279.24525235.29176719.29374058.	IPI	Function
GO:0005634	nucleus	20871596.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006325	chromatin organization	-	IEA	Process
GO:0006468	protein phosphorylation	-	IEA	Process
GO:0006974	cellular response to DNA damage stimulus	-	IEA	Process
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	22509028.	IMP	Function
GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	10938129.	IMP	Process
GO:0016032	viral process	-	IEA	Process
GO:0019899	enzyme binding	21555454.	IPI	Function
GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter	19103749.23086925.	IDA	Process
GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter	18039861.	IMP	Process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	19103749.	IDA	Process
GO:0045893	positive regulation of transcription, DNA-templated	21555454.	IMP	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	23086925.23317504.24360279.	IDA	Process
GO:0050727	regulation of inflammatory response	19103749.	IDA	Process
GO:0070577	lysine-acetylated histone binding	20871596.23086925.23317504.29176719.	IDA	Function
GO:0099122	RNA polymerase II C-terminal domain binding	22509028.	IDA	Function
GO:0106140	P-TEFb complex binding	24360279.	IDA	Function
GO:1901407	regulation of phosphorylation of RNA polymerase II C-terminal domain	23086925.	IDA	Process
GO:2001255	positive regulation of histone H3-K36 trimethylation	21555454.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

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Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.