EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25042803	Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth.	Mol Cell	2014 Aug 21	Shan C	doi: 10.1016/j.molcel.2014.06.020
22677172	Glycolytic cancer cells lacking 6-phosphogluconate dehydrogenase metabolize glucose to induce senescence.	FEBS Lett	2012 Jul 30	Sukhatme VP	doi: 10.1016/j.febslet.2012.05.052
29534964	Inhibiting 6-phosphogluconate dehydrogenase reverses doxorubicin resistance in anaplastic thyroid cancer via inhibiting NADPH-dependent metabolic reprogramming.	Biochem Biophys Res Commun	2018 Apr 15	Ma L	doi: 10.1016/j.bbrc.2018.03.079

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr1	10399096	5'UTR	rs199802743		0.09
BLCA	chr1	10419513	Missense_Mutation	novel	E436Q	0.26
BLCA	chr1	10404158	Splice_Region	rs764164193		0.27
BLCA	chr1	10411469	Missense_Mutation	NA	E191Q	0.25
BLCA	chr1	10419533	Silent	NA	L442L	0.2
BLCA	chr1	10418908	Missense_Mutation	rs757401268	A398P	0.13
BLCA	chr1	10417506	Missense_Mutation	novel	R369T	0.36
BRCA	chr1	10413127	Silent	NA	L240L	0.14
BRCA	chr1	10417396	Silent	rs202058165	I332I	0.06
BRCA	chr1	10417010	Missense_Mutation	NA	L290V	0.26
BRCA	chr1	10417004	Missense_Mutation	NA	R288W	0.43
CESC	chr1	10404272	Missense_Mutation	NA	E148Q	0.18
CESC	chr1	10400434	Missense_Mutation	NA	F42L	0.26
CESC	chr1	10413142	Silent	rs79502417	T245T	0.43
CESC	chr1	10419774	3'UTR	novel		0.11
CESC	chr1	10417005	Missense_Mutation	NA	R288Q	0.16
CESC	chr1	10411534	Silent	rs771042361	A212A	0.22
CESC	chr1	10400564	Missense_Mutation	novel	E86Q	0.21
COAD	chr1	10413166	Missense_Mutation	NA	K253N	0.45
COAD	chr1	10419429	Missense_Mutation	NA	R408W	0.3
COAD	chr1	10400516	Missense_Mutation	NA	R70W	0.25
COAD	chr1	10411462	Silent	NA	N188N	0.38
COAD	chr1	10400513	Missense_Mutation	NA	R69W	0.37
COAD	chr1	10418833	Missense_Mutation	NA	L373I	0.25
COAD	chr1	10399262	Intron	NA		0.39
COAD	chr1	10417032	Missense_Mutation	NA	R297I	0.33
COAD	chr1	10400445	Missense_Mutation	NA	E46G	0.07
DLBC	chr1	10419714	Missense_Mutation	novel	G473S	0.55
ESCA	chr1	10400482	Silent	novel	L58L	0.4
GBM	chr1	10404187	Missense_Mutation	novel	K119N	0.33
GBM	chr1	10419771	3'UTR	novel		0.2
GBM	chr1	10418837	Missense_Mutation	novel	G374A	0.04
GBM	chr1	10400396	Missense_Mutation	novel	C30R	0.09
HNSC	chr1	10413233	Missense_Mutation	rs764012709	V276I	0.36
HNSC	chr1	10417095	Nonsense_Mutation	novel	S318*	0.17
KIRC	chr1	10417112	Silent	NA	R324R	0.23
KIRP	chr1	10413095	Missense_Mutation	novel	S230P	0.24
LAML	chr1	10400472	Missense_Mutation	novel	A55V	0.12
LGG	chr1	10419628	Splice_Site	novel	X445_splice	0.33
LIHC	chr1	10411490	Missense_Mutation	NA	I198F	0.36
LIHC	chr1	10408086	Silent	rs762072878	T155T	0.06
LUAD	chr1	10413196	Silent	novel	T263T	0.71
LUAD	chr1	10417051	Missense_Mutation	novel	K303N	0.15
LUAD	chr1	10419867	3'UTR	novel		0.21
LUAD	chr1	10400551	Silent	novel	V81V	0.17
LUAD	chr1	10399113	5'UTR	novel		0.36
LUAD	chr1	10408121	Missense_Mutation	NA	G167A	0.17
LUAD	chr1	10399195	Intron	novel		0.31
LUSC	chr1	10400503	Silent	NA	L65L	0.3
LUSC	chr1	10419651	Missense_Mutation	novel	A452P	0.39
LUSC	chr1	10413214	Silent	novel	I269I	0.06
LUSC	chr1	10417509	Missense_Mutation	NA	S370T	0.21
OV	chr1	10418838	Silent	novel	G374G	0.05
OV	chr1	10417409	Missense_Mutation	NA	Q337E	0.09
OV	chr1	10400557	Missense_Mutation	novel	D83E	0.07
PAAD	chr1	10399106	5'UTR	rs755450753		0.14
PAAD	chr1	10413242	Missense_Mutation	novel	T279A	0.12
READ	chr1	10400514	Missense_Mutation	NA	R69Q	0.45
READ	chr1	10408083	Silent	novel	K154K	0.08
SARC	chr1	10419425	Missense_Mutation	novel	W406C	0.09
SKCM	chr1	10399205	Intron	novel		0.5
SKCM	chr1	10400479	Silent	rs773708751	S57S	0.46
SKCM	chr1	10411444	Silent	rs568894081	F182F	0.42
SKCM	chr1	10417396	Silent	rs202058165	I332I	0.28
SKCM	chr1	10419710	Silent	NA	G471G	0.12
SKCM	chr1	10419463	Missense_Mutation	NA	P419L	0.36
SKCM	chr1	10413216	Missense_Mutation	NA	S270F	0.49
SKCM	chr1	10417481	Missense_Mutation	NA	M361L	0.06
SKCM	chr1	10418875	Nonsense_Mutation	novel	Q387*	0.22
SKCM	chr1	10419421	Missense_Mutation	rs771627468	S405F	0.42
SKCM	chr1	10419494	Silent	NA	F429F	0.44
SKCM	chr1	10419796	3'UTR	novel		0.41
SKCM	chr1	10404246	Missense_Mutation	NA	P139L	0.26
SKCM	chr1	10408093	Nonsense_Mutation	NA	Q158*	0.14
SKCM	chr1	10417399	Silent	NA	I333I	0.09
SKCM	chr1	10411436	Missense_Mutation	NA	G180S	0.19
SKCM	chr1	10417396	Silent	rs202058165	I332I	0.48
SKCM	chr1	10419490	Missense_Mutation	rs562944056	S428F	0.13
SKCM	chr1	10419733	Missense_Mutation	rs749994897	S479L	0.13
SKCM	chr1	10419491	Silent	NA	S428S	0.49
SKCM	chr1	10404197	Missense_Mutation	NA	F123V	0.39
SKCM	chr1	10400486	Missense_Mutation	NA	E60K	0.39
SKCM	chr1	10418838	Silent	novel	G374G	0.34
SKCM	chr1	10413217	Silent	rs773445767	S270S	0.72
SKCM	chr1	10413235	Silent	novel	V276V	0.18
STAD	chr1	10419453	Missense_Mutation	NA	A416T	0.19
STAD	chr1	10400434	Missense_Mutation	NA	F42L	0.36
STAD	chr1	10413233	Missense_Mutation	rs764012709	V276I	0.28
STAD	chr1	10417471	Silent	NA	G357G	0.21
STAD	chr1	10413070	Missense_Mutation	novel	E221D	0.3
STAD	chr1	10413182	Missense_Mutation	novel	G259W	0.4
STAD	chr1	10419491	Silent	NA	S428S	0.59
STAD	chr1	10400520	Missense_Mutation	NA	I71N	0.38
STAD	chr1	10419783	3'UTR	novel		0.29
STAD	chr1	10413232	Silent	rs762844112	G275G	0.23
STAD	chr1	10417066	Missense_Mutation	novel	Q308H	0.08
STAD	chr1	10400430	Missense_Mutation	NA	D41A	0.2
THCA	chr1	10399078	5'Flank	rs756699070		0.41
THYM	chr1	10417441	Silent	rs530138934	T347T	0.41
UCEC	chr1	10419784	3'UTR	novel		0.09
UCEC	chr1	10400434	Missense_Mutation	NA	F42L	0.35
UCEC	chr1	10418898	Missense_Mutation	NA	F394L	0.27
UCEC	chr1	10403099	Missense_Mutation	novel	I98T	0.38
UCEC	chr1	10417409	Missense_Mutation	NA	Q337E	0.05
UCEC	chr1	10417004	Missense_Mutation	NA	R288W	0.37
UCEC	chr1	10413218	Missense_Mutation	rs143540325	A271T	0.28
UCEC	chr1	10417429	Silent	novel	R343R	0.11
UCEC	chr1	10400454	Missense_Mutation	novel	G49E	0.14
UCEC	chr1	10418861	Missense_Mutation	NA	R382Q	0.05
UCEC	chr1	10413232	Silent	rs762844112	G275G	0.26
UCEC	chr1	10417090	Missense_Mutation	novel	K316N	0.35
UCEC	chr1	10404164	Missense_Mutation	rs771917883	R112W	0.45
UCEC	chr1	10413154	Missense_Mutation	novel	H249Q	0.48
UCEC	chr1	10411533	Missense_Mutation	rs747211148	A212V	0.38
UCEC	chr1	10400514	Missense_Mutation	NA	R69Q	0.37
UCEC	chr1	10419647	Silent	rs765326865	F450F	0.49
UCEC	chr1	10419528	Missense_Mutation	NA	S441G	0.25
UCEC	chr1	10419418	Missense_Mutation	novel	D404G	0.41
UCEC	chr1	10417475	Missense_Mutation	rs181999445	A359T	0.44
UCEC	chr1	10417032	Missense_Mutation	NA	R297I	0.4
UCEC	chr1	10411444	Silent	rs568894081	F182F	0.39
UCEC	chr1	10419647	Silent	rs765326865	F450F	0.32
UCEC	chr1	10417024	Missense_Mutation	novel	K294N	0.05
UCEC	chr1	10399193	Intron	novel		0.27
UCEC	chr1	10419840	3'UTR	novel		0.13
UCEC	chr1	10399654	Missense_Mutation	novel	A12T	0.55
UCEC	chr1	10403103	Silent	novel	I99I	0.31
UCEC	chr1	10419705	Missense_Mutation	NA	T470A	0.16

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	DEL	0.1085	0.00029523
CHOL	DEL	0.7778	3.3987e-23
DLBC	DEL	0.1042	0.011841
HNSC	DEL	0.1418	7.0766e-07
KIRC	DEL	0.1439	2.3538e-09
KIRP	DEL	0.1736	1.462e-09
LUAD	DEL	0.1415	0.0024765
LUSC	DEL	0.3613	2.5882e-07
MESO	DEL	0.3448	2.434e-07
READ	DEL	0.3939	2.1758e-10
TGCT	DEL	0.18	0.00046313
UCS	DEL	0.3036	0.0051125

Survival Analysis

Cancer	P-value	Q-value
SARC	0.023	Kaplan-Meier Survival Analysis
MESO	0.049	Kaplan-Meier Survival Analysis
ACC	0.00024	Kaplan-Meier Survival Analysis
BLCA	0.029	Kaplan-Meier Survival Analysis
LAML	0.014	Kaplan-Meier Survival Analysis
GBM	0.032	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
DLBC	0.021	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
THCA	0.031	Kaplan-Meier Survival Analysis
LUAD	0.00042	Kaplan-Meier Survival Analysis
UVM	0.013	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000142657 (Gene tree)
Gene ID: 5226
Gene Symbol: PGD
Alias: N
Full Name: phosphogluconate dehydrogenase
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 21,920 bases
Position: chr1:10,398,592-10,420,511
Accession: 8891
RBP type: non-canonical RBP
Summary: 6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000487775	PGD-206	462	-	-	- (aa)	-	-
ENST00000270776	PGD-201	1885	-	ENSP00000270776	483 (aa)	-	P52209
ENST00000465632	PGD-203	642	-	ENSP00000466574	160 (aa)	-	K7EMN2
ENST00000496718	PGD-209	506	-	-	- (aa)	-	-
ENST00000498356	PGD-210	790	-	-	- (aa)	-	-
ENST00000460189	PGD-202	767	-	ENSP00000467362	256 (aa)	-	K7EPF6
ENST00000493288	PGD-208	476	-	-	- (aa)	-	-
ENST00000483936	PGD-205	680	-	ENSP00000466156	224 (aa)	-	K7ELN9
ENST00000491493	PGD-207	806	-	ENSP00000466358	205 (aa)	-	K7EM49
ENST00000477958	PGD-204	508	-	ENSP00000465311	63 (aa)	-	K7EJT3

Gene Model

Click here to download ENSG00000142657's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00030	Pentose phosphate pathway	KEGG
hsa00480	Glutathione metabolism	KEGG
hsa01100	Metabolic pathways	KEGG
hsa01200	Carbon metabolism	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000142657's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000142657	PGD	100	89.655	WBGene00012015	T25B9.9	100	69.485	Caenorhabditis_elegans
ENSG00000142657	PGD	99	88.889	FBgn0004654	Pgd	99	71.933	Drosophila_melanogaster
ENSG00000142657	PGD	99	77.778	YHR183W		99	65.306	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	-	ISS	Function
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006098	pentose-phosphate shunt	-	ISS	Process
GO:0006098	pentose-phosphate shunt	-	TAS	Process
GO:0009051	pentose-phosphate shunt, oxidative branch	3858849.	IDA	Process
GO:0019322	pentose biosynthetic process	-	IEA	Process
GO:0019521	D-gluconate metabolic process	-	IEA	Process
GO:0050661	NADP binding	-	IEA	Function
GO:0055114	oxidation-reduction process	3858849.	IDA	Process
GO:0070062	extracellular exosome	19056867.20458337.23533145.	HDA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.