EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact
TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
25042803Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth.Mol Cell2014 Aug 21Shan Cdoi: 10.1016/j.molcel.2014.06.020
22677172Glycolytic cancer cells lacking 6-phosphogluconate dehydrogenase metabolize glucose to induce senescence.FEBS Lett2012 Jul 30Sukhatme VPdoi: 10.1016/j.febslet.2012.05.052
29534964Inhibiting 6-phosphogluconate dehydrogenase reverses doxorubicin resistance in anaplastic thyroid cancer via inhibiting NADPH-dependent metabolic reprogramming.Biochem Biophys Res Commun2018 Apr 15Ma Ldoi: 10.1016/j.bbrc.2018.03.079

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1103990965'UTRrs1998027430.09
BLCAchr110419513Missense_MutationnovelE436Q0.26
BLCAchr110404158Splice_Regionrs7641641930.27
BLCAchr110411469Missense_MutationNAE191Q0.25
BLCAchr110419533SilentNAL442L0.2
BLCAchr110418908Missense_Mutationrs757401268A398P0.13
BLCAchr110417506Missense_MutationnovelR369T0.36
BRCAchr110413127SilentNAL240L0.14
BRCAchr110417396Silentrs202058165I332I0.06
BRCAchr110417010Missense_MutationNAL290V0.26
BRCAchr110417004Missense_MutationNAR288W0.43
CESCchr110404272Missense_MutationNAE148Q0.18
CESCchr110400434Missense_MutationNAF42L0.26
CESCchr110413142Silentrs79502417T245T0.43
CESCchr1104197743'UTRnovel0.11
CESCchr110417005Missense_MutationNAR288Q0.16
CESCchr110411534Silentrs771042361A212A0.22
CESCchr110400564Missense_MutationnovelE86Q0.21
COADchr110413166Missense_MutationNAK253N0.45
COADchr110419429Missense_MutationNAR408W0.3
COADchr110400516Missense_MutationNAR70W0.25
COADchr110411462SilentNAN188N0.38
COADchr110400513Missense_MutationNAR69W0.37
COADchr110418833Missense_MutationNAL373I0.25
COADchr110399262IntronNA0.39
COADchr110417032Missense_MutationNAR297I0.33
COADchr110400445Missense_MutationNAE46G0.07
DLBCchr110419714Missense_MutationnovelG473S0.55
ESCAchr110400482SilentnovelL58L0.4
GBMchr110404187Missense_MutationnovelK119N0.33
GBMchr1104197713'UTRnovel0.2
GBMchr110418837Missense_MutationnovelG374A0.04
GBMchr110400396Missense_MutationnovelC30R0.09
HNSCchr110413233Missense_Mutationrs764012709V276I0.36
HNSCchr110417095Nonsense_MutationnovelS318*0.17
KIRCchr110417112SilentNAR324R0.23
KIRPchr110413095Missense_MutationnovelS230P0.24
LAMLchr110400472Missense_MutationnovelA55V0.12
LGGchr110419628Splice_SitenovelX445_splice0.33
LIHCchr110411490Missense_MutationNAI198F0.36
LIHCchr110408086Silentrs762072878T155T0.06
LUADchr110413196SilentnovelT263T0.71
LUADchr110417051Missense_MutationnovelK303N0.15
LUADchr1104198673'UTRnovel0.21
LUADchr110400551SilentnovelV81V0.17
LUADchr1103991135'UTRnovel0.36
LUADchr110408121Missense_MutationNAG167A0.17
LUADchr110399195Intronnovel0.31
LUSCchr110400503SilentNAL65L0.3
LUSCchr110419651Missense_MutationnovelA452P0.39
LUSCchr110413214SilentnovelI269I0.06
LUSCchr110417509Missense_MutationNAS370T0.21
OVchr110418838SilentnovelG374G0.05
OVchr110417409Missense_MutationNAQ337E0.09
OVchr110400557Missense_MutationnovelD83E0.07
PAADchr1103991065'UTRrs7554507530.14
PAADchr110413242Missense_MutationnovelT279A0.12
READchr110400514Missense_MutationNAR69Q0.45
READchr110408083SilentnovelK154K0.08
SARCchr110419425Missense_MutationnovelW406C0.09
SKCMchr110399205Intronnovel0.5
SKCMchr110400479Silentrs773708751S57S0.46
SKCMchr110411444Silentrs568894081F182F0.42
SKCMchr110417396Silentrs202058165I332I0.28
SKCMchr110419710SilentNAG471G0.12
SKCMchr110419463Missense_MutationNAP419L0.36
SKCMchr110413216Missense_MutationNAS270F0.49
SKCMchr110417481Missense_MutationNAM361L0.06
SKCMchr110418875Nonsense_MutationnovelQ387*0.22
SKCMchr110419421Missense_Mutationrs771627468S405F0.42
SKCMchr110419494SilentNAF429F0.44
SKCMchr1104197963'UTRnovel0.41
SKCMchr110404246Missense_MutationNAP139L0.26
SKCMchr110408093Nonsense_MutationNAQ158*0.14
SKCMchr110417399SilentNAI333I0.09
SKCMchr110411436Missense_MutationNAG180S0.19
SKCMchr110417396Silentrs202058165I332I0.48
SKCMchr110419490Missense_Mutationrs562944056S428F0.13
SKCMchr110419733Missense_Mutationrs749994897S479L0.13
SKCMchr110419491SilentNAS428S0.49
SKCMchr110404197Missense_MutationNAF123V0.39
SKCMchr110400486Missense_MutationNAE60K0.39
SKCMchr110418838SilentnovelG374G0.34
SKCMchr110413217Silentrs773445767S270S0.72
SKCMchr110413235SilentnovelV276V0.18
STADchr110419453Missense_MutationNAA416T0.19
STADchr110400434Missense_MutationNAF42L0.36
STADchr110413233Missense_Mutationrs764012709V276I0.28
STADchr110417471SilentNAG357G0.21
STADchr110413070Missense_MutationnovelE221D0.3
STADchr110413182Missense_MutationnovelG259W0.4
STADchr110419491SilentNAS428S0.59
STADchr110400520Missense_MutationNAI71N0.38
STADchr1104197833'UTRnovel0.29
STADchr110413232Silentrs762844112G275G0.23
STADchr110417066Missense_MutationnovelQ308H0.08
STADchr110400430Missense_MutationNAD41A0.2
THCAchr1103990785'Flankrs7566990700.41
THYMchr110417441Silentrs530138934T347T0.41
UCECchr1104197843'UTRnovel0.09
UCECchr110400434Missense_MutationNAF42L0.35
UCECchr110418898Missense_MutationNAF394L0.27
UCECchr110403099Missense_MutationnovelI98T0.38
UCECchr110417409Missense_MutationNAQ337E0.05
UCECchr110417004Missense_MutationNAR288W0.37
UCECchr110413218Missense_Mutationrs143540325A271T0.28
UCECchr110417429SilentnovelR343R0.11
UCECchr110400454Missense_MutationnovelG49E0.14
UCECchr110418861Missense_MutationNAR382Q0.05
UCECchr110413232Silentrs762844112G275G0.26
UCECchr110417090Missense_MutationnovelK316N0.35
UCECchr110404164Missense_Mutationrs771917883R112W0.45
UCECchr110413154Missense_MutationnovelH249Q0.48
UCECchr110411533Missense_Mutationrs747211148A212V0.38
UCECchr110400514Missense_MutationNAR69Q0.37
UCECchr110419647Silentrs765326865F450F0.49
UCECchr110419528Missense_MutationNAS441G0.25
UCECchr110419418Missense_MutationnovelD404G0.41
UCECchr110417475Missense_Mutationrs181999445A359T0.44
UCECchr110417032Missense_MutationNAR297I0.4
UCECchr110411444Silentrs568894081F182F0.39
UCECchr110419647Silentrs765326865F450F0.32
UCECchr110417024Missense_MutationnovelK294N0.05
UCECchr110399193Intronnovel0.27
UCECchr1104198403'UTRnovel0.13
UCECchr110399654Missense_MutationnovelA12T0.55
UCECchr110403103SilentnovelI99I0.31
UCECchr110419705Missense_MutationNAT470A0.16

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
CESCDEL0.10850.00029523
CHOLDEL0.77783.3987e-23
DLBCDEL0.10420.011841
HNSCDEL0.14187.0766e-07
KIRCDEL0.14392.3538e-09
KIRPDEL0.17361.462e-09
LUADDEL0.14150.0024765
LUSCDEL0.36132.5882e-07
MESODEL0.34482.434e-07
READDEL0.39392.1758e-10
TGCTDEL0.180.00046313
UCSDEL0.30360.0051125

Survival Analysis
CancerP-value Q-value
SARC0.023

Kaplan-Meier Survival Analysis

MESO0.049

Kaplan-Meier Survival Analysis

ACC0.00024

Kaplan-Meier Survival Analysis

BLCA0.029

Kaplan-Meier Survival Analysis

LAML0.014

Kaplan-Meier Survival Analysis

GBM0.032

Kaplan-Meier Survival Analysis

LIHC0.0001

Kaplan-Meier Survival Analysis

DLBC0.021

Kaplan-Meier Survival Analysis

LGG0.0001

Kaplan-Meier Survival Analysis

THCA0.031

Kaplan-Meier Survival Analysis

LUAD0.00042

Kaplan-Meier Survival Analysis

UVM0.013

Kaplan-Meier Survival Analysis

Drugs

Select Dataset :


Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000142657 (Gene tree)
Gene ID
5226
Gene Symbol
PGD
Alias
N
Full Name
phosphogluconate dehydrogenase
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Plus strand
Length
21,920 bases
Position
chr1:10,398,592-10,420,511
Accession
8891
RBP type
non-canonical RBP
Summary
6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000487775PGD-206462--- (aa)--
ENST00000270776PGD-2011885-ENSP00000270776483 (aa)-P52209
ENST00000465632PGD-203642-ENSP00000466574160 (aa)-K7EMN2
ENST00000496718PGD-209506--- (aa)--
ENST00000498356PGD-210790--- (aa)--
ENST00000460189PGD-202767-ENSP00000467362256 (aa)-K7EPF6
ENST00000493288PGD-208476--- (aa)--
ENST00000483936PGD-205680-ENSP00000466156224 (aa)-K7ELN9
ENST00000491493PGD-207806-ENSP00000466358205 (aa)-K7EM49
ENST00000477958PGD-204508-ENSP0000046531163 (aa)-K7EJT3
Gene Model
Click here to download ENSG00000142657's gene model file
Pathways
Pathway IDPathway NameSource
hsa00030Pentose phosphate pathwayKEGG
hsa00480Glutathione metabolismKEGG
hsa01100Metabolic pathwaysKEGG
hsa01200Carbon metabolismKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000142657's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000142657PGD10089.655WBGene00012015T25B9.910069.485Caenorhabditis_elegans
ENSG00000142657PGD9988.889FBgn0004654Pgd9971.933Drosophila_melanogaster
ENSG00000142657PGD9977.778YHR183W9965.306Saccharomyces_cerevisiae
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0004616phosphogluconate dehydrogenase (decarboxylating) activity-ISSFunction
GO:0005634nucleus21630459.HDAComponent
GO:0005829cytosol-TASComponent
GO:0006098pentose-phosphate shunt-ISSProcess
GO:0006098pentose-phosphate shunt-TASProcess
GO:0009051pentose-phosphate shunt, oxidative branch3858849.IDAProcess
GO:0019322pentose biosynthetic process-IEAProcess
GO:0019521D-gluconate metabolic process-IEAProcess
GO:0050661NADP binding-IEAFunction
GO:0055114oxidation-reduction process3858849.IDAProcess
GO:0070062extracellular exosome19056867.20458337.23533145.HDAComponent
To top

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us