EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26148251	Functional analysis of phosphorylation of the mitotic centromere-associated kinesin by Aurora B kinase in human tumor cells.	Cell Cycle	2015	Ritter A	doi: 10.1080/15384101.2015.1068481
29244835	Tumor suppressor protein p53-mediated repression of human mitotic centromere-associated kinesin gene expression is exerted via down-regulation of Sp1 level.	PLoS One	2017 Dec 15	Jun DY	doi: 10.1371/journal.pone.0189698
27563815	KIF-2C expression is correlated with poor prognosis of operable esophageal squamous cell carcinoma male patients.	Oncotarget	2016 Dec 6	Duan H	doi: 10.18632/oncotarget.11492.
22363599	Mitosis phase enrichment with identification of mitotic centromere-associated kinesin as a therapeutic target in castration-resistant prostate cancer.	PLoS One	2012	Sircar K	doi: 10.1371/journal.pone.0031259
25002494	Ras transformation uncouples the kinesin-coordinated cellular nutrient response.	Proc Natl Acad Sci U S A	2014 Jul 22	Zaganjor E	doi: 10.1073/pnas.1411016111
23564489	Evidence of colorectal cancer-associated mutation in MCAK: a computational report.	Cell Biochem Biophys	2013	Kumar A	doi: 10.1007/s12013-013-9572-1.
18506187	Mitotic centromere-associated kinesin is a novel marker for prognosis and lymph node metastasis in colorectal cancer.	Br J Cancer	2008 Jun 3	Ishikawa K	doi: 10.1038/sj.bjc.6604379
21165574	Identification of HLA-A0201/-A2402-restricted CTL epitope-peptides derived from a novel cancer/testis antigen, MCAK, and induction of a specific antitumor immune response.	Oncol Rep	2011 Feb	Kawamoto M	doi: 10.3892/or.2010.1101
17653072	Clinicopathological and biological significance of mitotic centromere-associated kinesin overexpression in human gastric cancer.	Br J Cancer	2007 Aug 20	Nakamura Y	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr1	44761956	Missense_Mutation	novel	T575I	0.41
BLCA	chr1	44739978	Missense_Mutation	NA	A16T	0.15
BLCA	chr1	44747422	Silent	novel	L68L	0.11
BLCA	chr1	44760334	Silent	NA	F474F	0.54
BLCA	chr1	44762239	Intron	novel		0.18
BLCA	chr1	44760446	Missense_Mutation	novel	E512Q	0.16
BLCA	chr1	44767205	3'UTR	novel		0.56
BLCA	chr1	44762542	Splice_Region	novel		0.18
BLCA	chr1	44756100	Silent	novel	V280V	0.04
BLCA	chr1	44753831	Missense_Mutation	novel	Q221E	0.4
BLCA	chr1	44757925	Silent	novel	L362L	0.3
BLCA	chr1	44758046	Splice_Region	novel		0.3
BLCA	chr1	44762388	Silent	novel	Q598Q	0.56
BRCA	chr1	44761971	Missense_Mutation	NA	R580T	0.25
BRCA	chr1	44759251	Missense_Mutation	novel	D424N	0.08
BRCA	chr1	44747662	Missense_Mutation	rs760237957	R93Q	0.58
BRCA	chr1	44755961	Silent	novel	R264R	0.5
BRCA	chr1	44756095	Missense_Mutation	novel	D279H	0.05
CESC	chr1	44757554	Splice_Site	NA	X326_splice	0.32
CESC	chr1	44766888	Silent	NA	T678T	0.21
CESC	chr1	44766844	Missense_Mutation	novel	E664Q	0.49
CESC	chr1	44741005	Missense_Mutation	novel	E55Q	0.1
CESC	chr1	44747393	Missense_Mutation	NA	D59H	0.18
CESC	chr1	44760318	Missense_Mutation	rs773951865	R469H	0.64
CESC	chr1	44762547	Missense_Mutation	NA	L620F	0.26
CESC	chr1	44750503	Silent	NA	E126E	0.21
COAD	chr1	44761979	Missense_Mutation	NA	D583N	0.23
COAD	chr1	44756230	Missense_Mutation	NA	V324I	0.4
COAD	chr1	44758085	Missense_Mutation	novel	Y390F	0.32
COAD	chr1	44767103	Missense_Mutation	novel	I701N	0.52
COAD	chr1	44758070	Missense_Mutation	novel	K385T	0.1
COAD	chr1	44756178	Missense_Mutation	novel	N306K	0.15
COAD	chr1	44750495	Missense_Mutation	NA	A124T	0.33
COAD	chr1	44760451	Silent	rs144656043	G513G	0.41
COAD	chr1	44759239	Missense_Mutation	novel	R420C	0.36
COAD	chr1	44754844	Missense_Mutation	novel	P253H	0.12
COAD	chr1	44754810	Missense_Mutation	novel	T242P	0.05
COAD	chr1	44753138	Frame_Shift_Ins	novel	*T150Hfs2**	0.06
ESCA	chr1	44762557	Missense_Mutation	novel	E624Q	0.21
ESCA	chr1	44755945	Missense_Mutation	novel	I259T	0.09
GBM	chr1	44762629	Missense_Mutation	novel	A648T	0.2
GBM	chr1	44766904	Missense_Mutation	novel	E684K	0.41
GBM	chr1	44756207	Missense_Mutation	novel	D316V	0.04
GBM	chr1	44747396	Missense_Mutation	novel	D60H	0.39
GBM	chr1	44759273	Missense_Mutation	novel	V431E	0.07
GBM	chr1	44766859	Missense_Mutation	novel	T669P	0.15
GBM	chr1	44760436	Missense_Mutation	novel	Q508H	0.14
HNSC	chr1	44756194	Missense_Mutation	novel	D312H	0.16
HNSC	chr1	44753178	Silent	novel	L162L	0.36
HNSC	chr1	44739874	5'UTR	novel		0.64
KIRP	chr1	44740979	Missense_Mutation	NA	A46E	0.12
LAML	chr1	44757936	Frame_Shift_Del	novel	*Q367Rfs18**	0.08
LAML	chr1	44754772	Missense_Mutation	novel	N229I	0.08
LGG	chr1	44761920	Missense_Mutation	novel	A563V	0.26
LGG	chr1	44758091	Missense_Mutation	novel	K392R	0.44
LIHC	chr1	44767190	3'UTR	novel		0.26
LUAD	chr1	44760441	Missense_Mutation	novel	R510L	0.12
LUAD	chr1	44756237	Frame_Shift_Del	novel		0.2
LUAD	chr1	44758053	Silent	NA	R379R	0.13
LUAD	chr1	44762343	Splice_Region	novel		0.25
LUAD	chr1	44739869	5'UTR	novel		0.09
LUAD	chr1	44759270	Missense_Mutation	novel	Q430L	0.08
LUAD	chr1	44760680	Missense_Mutation	novel	G554A	0.41
LUAD	chr1	44761964	Missense_Mutation	NA	T578S	0.43
LUAD	chr1	44766853	Nonsense_Mutation	NA	E667*	0.5
LUAD	chr1	44747432	Missense_Mutation	novel	L72F	0.24
LUAD	chr1	44755928	Splice_Site	novel	X254_splice	0.16
LUSC	chr1	44767117	Missense_Mutation	NA	L706M	0.19
LUSC	chr1	44766908	Missense_Mutation	NA	S685C	0.35
LUSC	chr1	44767104	Missense_Mutation	NA	I701M	0.36
LUSC	chr1	44758130	Missense_Mutation	NA	Y405C	0.25
LUSC	chr1	44757927	Missense_Mutation	novel	S363C	0.3
LUSC	chr1	44760481	Silent	novel	L523L	0.2
LUSC	chr1	44760678	Missense_Mutation	NA	I553M	0.15
LUSC	chr1	44747685	Missense_Mutation	NA	P101S	0.19
LUSC	chr1	44766880	Silent	rs370355160	L676L	0.19
OV	chr1	44753213	Frame_Shift_Ins	novel	*H174Qfs41**	0.03
OV	chr1	44760383	Frame_Shift_Del	novel	*V491Rfs6**	0.33
OV	chr1	44747386	Missense_Mutation	NA	I56M	0.2
OV	chr1	44740970	Missense_Mutation	novel	V43E	0.19
OV	chr1	44754844	Missense_Mutation	novel	P253H	0.12
PRAD	chr1	44760327	Missense_Mutation	rs150935880	A472V	0.32
PRAD	chr1	44766946	Nonsense_Mutation	rs769328188	R698*	0.38
READ	chr1	44750544	Missense_Mutation	rs200680875	R140H	0.13
READ	chr1	44756220	Silent	rs146490098	S320S	0.28
READ	chr1	44762435	Missense_Mutation	rs199917085	A614V	0.33
READ	chr1	44767318	3'UTR	novel		0.18
READ	chr1	44747396	Missense_Mutation	NA	D60Y	0.2
READ	chr1	44757606	Missense_Mutation	novel	T343N	0.39
SKCM	chr1	44747414	Missense_Mutation	novel	P66S	0.45
SKCM	chr1	44767230	3'UTR	novel		0.62
SKCM	chr1	44747685	Missense_Mutation	NA	P101S	0.33
SKCM	chr1	44747686	Missense_Mutation	novel	P101L	0.36
SKCM	chr1	44753806	Missense_Mutation	novel	N212K	0.25
SKCM	chr1	44756105	Missense_Mutation	novel	S282F	0.18
SKCM	chr1	44746749	Intron	novel		0.37
SKCM	chr1	44760321	Missense_Mutation	NA	S470F	0.39
SKCM	chr1	44754769	Missense_Mutation	NA	P228L	0.23
SKCM	chr1	44762570	Missense_Mutation	NA	S628F	0.31
SKCM	chr1	44739975	Missense_Mutation	NA	L15F	0.12
SKCM	chr1	44760423	Missense_Mutation	rs777605365	S504N	0.28
SKCM	chr1	44750462	Missense_Mutation	rs759800312	R113C	0.34
SKCM	chr1	44757615	Missense_Mutation	NA	A346V	0.52
SKCM	chr1	44767152	Silent	NA	Q717Q	0.27
SKCM	chr1	44761924	Silent	NA	T564T	0.35
STAD	chr1	44760410	Missense_Mutation	rs766564343	A500T	0.48
STAD	chr1	44753233	Missense_Mutation	novel	S181A	0.08
STAD	chr1	44753243	Missense_Mutation	NA	P184H	0.31
STAD	chr1	44750544	Missense_Mutation	rs200680875	R140H	0.56
STAD	chr1	44760410	Missense_Mutation	rs766564343	A500T	0.37
STAD	chr1	44757923	Missense_Mutation	novel	L362F	0.05
STAD	chr1	44767099	Missense_Mutation	NA	V700L	0.32
TGCT	chr1	44767245	3'UTR	rs540857768		0.51
UCEC	chr1	44754774	Missense_Mutation	NA	W230R	0.32
UCEC	chr1	44760348	Missense_Mutation	rs755097249	R479Q	0.33
UCEC	chr1	44759329	Missense_Mutation	rs772245374	D450N	0.32
UCEC	chr1	44757585	Missense_Mutation	novel	I336T	0.16
UCEC	chr1	44766936	Silent	novel	F694F	0.12
UCEC	chr1	44750521	Silent	NA	E132E	0.51
UCEC	chr1	44756094	Silent	NA	I278I	0.34
UCEC	chr1	44757626	Missense_Mutation	novel	T350A	0.06
UCEC	chr1	44767152	Missense_Mutation	NA	Q717H	0.4
UCEC	chr1	44750448	Missense_Mutation	novel	R108Q	0.51
UCEC	chr1	44750486	Missense_Mutation	rs777985755	R121C	0.35
UCEC	chr1	44747669	Silent	novel	S95S	0.42
UCEC	chr1	44760621	Missense_Mutation	novel	K534N	0.47
UCEC	chr1	44767157	Missense_Mutation	novel	S719I	0.32
UCEC	chr1	44740910	Splice_Region	rs770274652		0.4
UCEC	chr1	44746714	Intron	rs200352761		0.45
UCEC	chr1	44762641	Missense_Mutation	novel	L652I	0.54
UCEC	chr1	44740959	Silent	novel	S39S	0.14
UCEC	chr1	44739911	5'UTR	novel		0.21
UCEC	chr1	44753221	Nonsense_Mutation	NA	R177*	0.25
UCEC	chr1	44761919	Missense_Mutation	novel	A563S	0.55
UCEC	chr1	44760696	Silent	NA	T559T	0.37
UCEC	chr1	44761923	Missense_Mutation	rs751382202	T564M	0.43
UCEC	chr1	44750479	Silent	novel	S118S	0.24
UCEC	chr1	44760633	Silent	rs775625812	P538P	0.42
UCEC	chr1	44762560	Missense_Mutation	novel	E625K	0.37
UCEC	chr1	44756219	Missense_Mutation	rs771808247	S320L	0.37
UCEC	chr1	44753251	Missense_Mutation	NA	S187P	0.05
UCEC	chr1	44753252	Missense_Mutation	rs766621230	S187L	0.05
UCEC	chr1	44755966	Missense_Mutation	NA	R266H	0.14
UCEC	chr1	44753778	Missense_Mutation	novel	N203S	0.09
UCEC	chr1	44755965	Missense_Mutation	NA	R266C	0.35
UCEC	chr1	44767139	Missense_Mutation	novel	Q713R	0.11
UCEC	chr1	44747432	Missense_Mutation	novel	L72F	0.43
UCEC	chr1	44762256	Intron	novel		0.18
UCEC	chr1	44756201	Missense_Mutation	novel	A314V	0.28
UCEC	chr1	44760410	Missense_Mutation	rs766564343	A500T	0.38
UCEC	chr1	44739894	5'UTR	novel		0.43
UCEC	chr1	44760410	Missense_Mutation	rs766564343	A500T	0.14
UCEC	chr1	44753735	Missense_Mutation	novel	R189W	0.14
UCEC	chr1	44761954	Silent	NA	Y574Y	0.14
UCEC	chr1	44760596	Missense_Mutation	NA	C526Y	0.21
UCEC	chr1	44762435	Missense_Mutation	rs199917085	A614V	0.31
UCEC	chr1	44762561	Missense_Mutation	novel	E625G	0.33
UCEC	chr1	44739873	5'UTR	novel		0.28
UCEC	chr1	44760410	Missense_Mutation	rs766564343	A500T	0.55
UCEC	chr1	44758062	Missense_Mutation	NA	F382L	0.04
UCEC	chr1	44762592	Silent	rs369365260	N635N	0.26
UCEC	chr1	44766888	Silent	novel	T678T	0.22
UCEC	chr1	44767312	3'UTR	novel		0.2
UCEC	chr1	44756220	Silent	rs146490098	S320S	0.34
UCEC	chr1	44766885	Missense_Mutation	NA	E677D	0.28
UCEC	chr1	44750487	Missense_Mutation	rs551429749	R121H	0.34
UCEC	chr1	44762435	Missense_Mutation	rs199917085	A614V	0.37

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.0833	0.011841
TGCT	DEL	0.1533	0.00046313

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0073	Kaplan-Meier Survival Analysis
STAD	0.006	Kaplan-Meier Survival Analysis
SARC	0.0012	Kaplan-Meier Survival Analysis
MESO	0.00013	Kaplan-Meier Survival Analysis
SKCM	0.0088	Kaplan-Meier Survival Analysis
KIRP	0.0001	Kaplan-Meier Survival Analysis
PAAD	0.00017	Kaplan-Meier Survival Analysis
KICH	0.0093	Kaplan-Meier Survival Analysis
UCEC	0.00025	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
DLBC	0.017	Kaplan-Meier Survival Analysis
LUAD	0.00012	Kaplan-Meier Survival Analysis
UVM	0.034	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000142945 (Gene tree)
Gene ID: 11004
Gene Symbol: KIF2C
Alias: MCAK|CT139|KNSL6
Full Name: kinesin family member 2C
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 28,056 bases
Position: chr1:44,739,712-44,767,767
Accession: 6393
RBP type: non-canonical RBP
Summary: This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000423289	KIF2C-203	320	-	ENSP00000402172	107 (aa)	-	H0Y5Z9
ENST00000455186	KIF2C-205	908	-	ENSP00000395050	287 (aa)	-	Q5JR89
ENST00000452259	KIF2C-204	1124	-	ENSP00000410346	336 (aa)	-	Q5JR91
ENST00000372217	KIF2C-201	2955	XM_011540540	ENSP00000361291	671 (aa)	XP_011538842	Q99661
ENST00000372224	KIF2C-202	2879	-	ENSP00000361298	725 (aa)	-	Q99661
ENST00000493027	KIF2C-208	1091	-	-	- (aa)	-	-
ENST00000472235	KIF2C-206	480	-	-	- (aa)	-	-
ENST00000480574	KIF2C-207	783	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000142945's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000142945's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000142945	KIF2C	57	83.607	FBgn0030268	Klp10A	78	49.383	Drosophila_melanogaster

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000278	mitotic cell cycle	9434124.	TAS	Process
GO:0000775	chromosome, centromeric region	14960279.	IDA	Component
GO:0000776	kinetochore	23891108.	IDA	Component
GO:0000776	kinetochore	14960279.	IDA	Component
GO:0000777	condensed chromosome kinetochore	-	IEA	Component
GO:0003777	microtubule motor activity	21873635.	IBA	Function
GO:0005515	protein binding	11092768.19543227.19632184.21820309.26496610.27173435.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005813	centrosome	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005871	kinesin complex	21873635.	IBA	Component
GO:0005874	microtubule	21873635.	IBA	Component
GO:0005881	cytoplasmic microtubule	-	ISS	Component
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	-	TAS	Process
GO:0007018	microtubule-based movement	21873635.	IBA	Process
GO:0007018	microtubule-based movement	-	TAS	Process
GO:0007019	microtubule depolymerization	21820309.	IDA	Process
GO:0007019	microtubule depolymerization	19060894.	IMP	Process
GO:0007019	microtubule depolymerization	26323690.	TAS	Process
GO:0007080	mitotic metaphase plate congression	15843429.	IMP	Process
GO:0008017	microtubule binding	21873635.	IBA	Function
GO:0008283	cell proliferation	9434124.	TAS	Process
GO:0015630	microtubule cytoskeleton	-	IDA	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0016887	ATPase activity	21873635.	IBA	Function
GO:0019237	centromeric DNA binding	9434124.	TAS	Function
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	-	TAS	Process
GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity	14718566.	IMP	Process
GO:0035371	microtubule plus-end	21820309.23891108.	IDA	Component
GO:0035371	microtubule plus-end	26323690.	TAS	Component
GO:0051010	microtubule plus-end binding	19632184.	IDA	Function
GO:0051301	cell division	-	IEA	Process
GO:0051310	metaphase plate congression	23891108.	IMP	Process
GO:0051315	attachment of mitotic spindle microtubules to kinetochore	23891108.	IMP	Process
GO:0051983	regulation of chromosome segregation	19060894.	IMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.