EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28713954	MicroRNA139 suppressed tumor cell proliferation, migration and invasion by directly targeting HDGF in epithelial ovarian cancer.	Mol Med Rep	2017 Sep	Liu J	doi: 10.3892/mmr.2017.6956
23673296	Downregulation of miR-497 promotes tumor growth and angiogenesis by targeting HDGF in non-small cell lung cancer.	Biochem Biophys Res Commun	2013 Jun 7	Zhao WY	doi: 10.1016/j.bbrc.2013.05.010
24072730	p53 and hepatoma-derived growth factor expression and their clinicopathological association with Ewing family tumour.	J Clin Pathol	2014 Mar	Yang Y	doi: 10.1136/jclinpath-2013-201705
23793608	Identification of hepatoma-derived growth factor as a potential prognostic and diagnostic marker for extrahepatic cholangiocarcinoma.	World J Surg	2013 Oct	Han Y	doi: 10.1007/s00268-013-2132-4.
23536873	Up-regulation of hepatoma-derived growth factor facilitates tumor progression in malignant melanoma [corrected].	PLoS One	2013	Tsai HE	doi: 10.1371/journal.pone.0059345
27692835	Hepatoma-derived growth factor: A survival-related protein in prostate oncogenesis and a potential target for vitamin K2.	Urol Oncol	2016 Nov	Shetty A	doi: 10.1016/j.urolonc.2016.05.027
29300772	Downregulated expression of hepatoma-derived growth factor inhibits migration and invasion of prostate cancer cells by suppressing epithelial-mesenchymal transition and MMP2, MMP9.	PLoS One	2018 Jan 4	Yang F	doi: 10.1371/journal.pone.0190725
26612514	Hepatoma derived growth factor (HDGF) dynamics in ovarian cancer cells.	Apoptosis	2016 Mar	Giri K	doi: 10.1007/s10495-015-1200-7.
22247069	Hepatoma-derived growth factor regulates breast cancer cell invasion by modulating epithelial--mesenchymal transition.	J Pathol	2012 Oct	Chen SC	doi: 10.1002/path.3988
15870924	Hepatoma-derived growth factor as a prognostic marker in completely resected non-small-cell lung cancer.	Oncol Rep	2005 Jun	Iwasaki T	-
24891187	MiR-195 targets HDGF to inhibit proliferation and invasion of NSCLC cells.	Tumour Biol	2014 Sep	Guo H	doi: 10.1007/s13277-014-2153-0
18478933	[Expression of HDGF and its implication in stage I non-small cell lung cancer].	Zhonghua Zhong Liu Za Zhi	2007 Dec	Zhou SJ	-
25773828	Prognostic role of hepatoma-derived growth factor in solid tumors of Eastern Asia: a systematic review and meta- analysis.	Asian Pac J Cancer Prev	2015	Bao CH	-
23609195	Downregulated expression of hepatoma-derived growth factor (HDGF) reduces gallbladder cancer cell proliferation and invasion.	Med Oncol	2013	Li M	doi: 10.1007/s12032-013-0587-7
21426662	[Aberrant expression of HDGF and its prognostic values in surgically resected non-small cell lung cancer].	Zhongguo Fei Ai Za Zhi	2011 Mar	Zhang J	doi: 10.3779/j.issn.1009-3419.2011.03.06.
24276755	miR-141 suppresses proliferation and motility of gastric cancer cells by targeting HDGF.	Mol Cell Biochem	2014 Mar	Chen B	doi: 10.1007/s11010-013-1912-3
22361040	The expression and prognostic significance of hepatoma-derived growth factor in oral cancer.	Oral Oncol	2012 Jul	Lin YW	doi: 10.1016/j.oraloncology.2012.01.014
22006999	p53 negatively regulates the hepatoma growth factor HDGF.	Cancer Res	2011 Nov 15	Sasaki Y	doi: 10.1158/0008-5472.CAN-11-1053
24770635	HDGF and ADAM9 are novel molecular staging biomarkers, prognostic biomarkers and predictive biomarkers for adjuvant chemotherapy in surgically resected stage I non-small cell lung cancer.	J Cancer Res Clin Oncol	2014 Aug	Zhang J	doi: 10.1007/s00432-014-1687-2
26780929	MicroRNA-497 targets hepatoma-derived growth factor and suppresses human prostate cancer cell motility.	Mol Med Rep	2016 Mar	Wu D	doi: 10.3892/mmr.2016.4756
28592712	High Serum HDGF Levels Are Predictive of Bone Metastasis and Unfavorable Prognosis in Non-Small Cell Lung Cancer.	Tohoku J Exp Med	2017 Jun	Zhang G	doi: 10.1620/tjem.242.101.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr1	156743400	3'UTR	novel		0.09
BLCA	chr1	156745081	Frame_Shift_Del	novel	*N77Tfs78**	0.34
BLCA	chr1	156751280	Intron	novel		0.65
BLCA	chr1	156743403	3'UTR	novel		0.27
BLCA	chr1	156751370	Missense_Mutation	novel	M20I	0.17
BLCA	chr1	156751441	5'UTR	novel		0.38
BLCA	chr1	156743298	3'UTR	novel		0.18
BLCA	chr1	156751340	Splice_Region	novel		0.36
BLCA	chr1	156744232	Silent	novel	V140V	0.47
BRCA	chr1	156752190	5'Flank	novel		0.21
BRCA	chr1	156742576	3'UTR	novel		0.14
BRCA	chr1	156744187	Silent	NA	K155K	0.11
CESC	chr1	156745349	Nonsense_Mutation	novel	V38*	0.38
CESC	chr1	156742526	3'UTR	novel		0.3
CESC	chr1	156742968	3'UTR	rs574912091		0.32
CESC	chr1	156744225	Nonsense_Mutation	NA	E143*	0.18
CESC	chr1	156742750	3'UTR	novel		0.27
CESC	chr1	156751476	5'UTR	NA		0.42
CESC	chr1	156742766	3'UTR	novel		0.39
CHOL	chr1	156743657	Missense_Mutation	novel	H237Q	0.2
COAD	chr1	156745312	Frame_Shift_Del	NA	*F50Sfs105**	0.26
COAD	chr1	156745308	Silent	novel	G51G	0.34
COAD	chr1	156745297	Missense_Mutation	novel	T55M	0.32
COAD	chr1	156745312	Frame_Shift_Del	NA	*F50Sfs105**	0.75
COAD	chr1	156745311	Frame_Shift_Ins	NA	*G51Rfs63**	0.37
COAD	chr1	156744266	Missense_Mutation	NA	A129V	0.33
COAD	chr1	156745312	Frame_Shift_Del	NA	*F50Sfs105**	0.46
COAD	chr1	156745312	Frame_Shift_Del	NA	*F50Sfs105**	0.13
COAD	chr1	156752365	5'Flank	novel		0.19
COAD	chr1	156745312	Frame_Shift_Del	NA	*F50Sfs105**	0.39
COAD	chr1	156745312	Frame_Shift_Del	NA	*F50Sfs105**	0.29
COAD	chr1	156743847	Missense_Mutation	novel	N174T	0.15
COAD	chr1	156745312	Frame_Shift_Del	NA	*F50Sfs105**	0.18
ESCA	chr1	156752347	5'Flank	novel		0.29
ESCA	chr1	156744173	Missense_Mutation	novel	D160V	0.36
GBM	chr1	156743300	3'UTR	novel		0.2
GBM	chr1	156744166	Silent	NA	L162L	0.47
HNSC	chr1	156751422	Missense_Mutation	novel	R3Q	0.23
HNSC	chr1	156751456	5'UTR	novel		0.2
HNSC	chr1	156743375	3'UTR	novel		0.25
HNSC	chr1	156743432	3'UTR	novel		0.45
HNSC	chr1	156743827	Frame_Shift_Del	novel	*E181Rfs144**	0.15
KIRC	chr1	156752137	5'Flank	novel		0.34
KIRP	chr1	156743755	Missense_Mutation	rs375226201	G205S	0.52
KIRP	chr1	156743695	Missense_Mutation	novel	T225S	0.34
KIRP	chr1	156745311	Frame_Shift_Ins	NA	*G51Rfs63**	0.65
LAML	chr1	156743804	Silent	NA	E188E	0.29
LGG	chr1	156743442	3'UTR	rs11556973		0.5
LUAD	chr1	156744290	Missense_Mutation	novel	G121V	0.25
LUAD	chr1	156745136	Missense_Mutation	novel	G59C	0.25
LUAD	chr1	156751409	Silent	novel	Q7Q	0.15
LUAD	chr1	156743761	Nonsense_Mutation	novel	E203*	0.18
LUAD	chr1	156743745	Missense_Mutation	rs201482955	R208Q	0.27
LUSC	chr1	156744165	Nonsense_Mutation	novel	E163*	0.35
LUSC	chr1	156744267	Missense_Mutation	NA	A129S	0.61
LUSC	chr1	156743737	Missense_Mutation	novel	P211S	0.17
LUSC	chr1	156743430	3'UTR	novel		0.61
LUSC	chr1	156743788	Nonsense_Mutation	novel	E194*	0.23
OV	chr1	156743209	3'UTR	rs532200506		0.14
OV	chr1	156745048	Missense_Mutation	novel	E88V	0.05
OV	chr1	156743355	3'UTR	novel		0.06
PAAD	chr1	156745018	Missense_Mutation	novel	S98Y	0.22
PCPG	chr1	156743321	3'UTR	novel		0.15
PRAD	chr1	156744302	Missense_Mutation	novel	E117G	0.07
READ	chr1	156743361	3'UTR	novel		0.1
SARC	chr1	156745118	Missense_Mutation	novel	P65S	0.29
SKCM	chr1	156744344	Missense_Mutation	NA	S103Y	0.23
SKCM	chr1	156751449	5'UTR	novel		0.07
SKCM	chr1	156744344	Missense_Mutation	NA	S103F	0.26
SKCM	chr1	156743316	3'UTR	novel		0.26
SKCM	chr1	156745133	Missense_Mutation	NA	P60S	0.44
STAD	chr1	156743324	3'UTR	novel		0.4
STAD	chr1	156745312	Frame_Shift_Del	NA	*F50Sfs105**	0.52
STAD	chr1	156745113	Silent	rs752829566	Y66Y	0.16
STAD	chr1	156743396	3'UTR	novel		0.11
STAD	chr1	156743735	In_Frame_Del	novel	G205_P211del	0.12
STAD	chr1	156745312	Frame_Shift_Del	NA	*F50Sfs105**	0.16
STAD	chr1	156744335	Frame_Shift_Del	novel	*K106Rfs49**	0.35
STAD	chr1	156744311	Missense_Mutation	NA	P114Q	0.27
STAD	chr1	156745312	Frame_Shift_Del	NA	*F50Sfs105**	0.17
STAD	chr1	156751448	5'UTR	novel		0.19
STAD	chr1	156745312	Frame_Shift_Del	NA	*F50Sfs105**	0.46
TGCT	chr1	156743435	3'UTR	novel		0.21
UCEC	chr1	156744239	Missense_Mutation	novel	K138R	0.29
UCEC	chr1	156745311	Frame_Shift_Ins	NA	*G51Rfs63**	0.4
UCEC	chr1	156743403	3'UTR	novel		0.37
UCEC	chr1	156751384	Missense_Mutation	novel	V16L	0.35
UCEC	chr1	156743174	3'UTR	novel		0.47
UCEC	chr1	156752234	5'Flank	NA		0.21
UCEC	chr1	156752387	5'Flank	novel		0.28
UCEC	chr1	156742452	3'UTR	novel		0.28
UCEC	chr1	156743170	3'UTR	novel		0.5
UCEC	chr1	156745112	Missense_Mutation	NA	E67K	0.1
UCEC	chr1	156743397	3'UTR	novel		0.19
UCEC	chr1	156752258	5'Flank	NA		0.23
UCEC	chr1	156742526	3'UTR	novel		0.33
UCEC	chr1	156752366	5'Flank	novel		0.22
UCEC	chr1	156744193	Silent	rs201820242	A153A	0.26
UCEC	chr1	156742522	3'UTR	novel		0.49
UCEC	chr1	156743765	Frame_Shift_Del	novel	*S202Lfs123**	0.28
UCEC	chr1	156745312	Frame_Shift_Del	NA	*F50Sfs105**	0.22
UCEC	chr1	156742766	3'UTR	novel		0.39
UCEC	chr1	156743320	3'UTR	novel		0.4
UCEC	chr1	156744177	Missense_Mutation	novel	G159W	0.06
UCEC	chr1	156742526	3'UTR	novel		0.29
UCEC	chr1	156742697	3'UTR	novel		0.31
UCEC	chr1	156745114	Missense_Mutation	novel	Y66C	0.28
UCEC	chr1	156752357	5'Flank	novel		0.38
UCEC	chr1	156742474	3'UTR	novel		0.28
UCEC	chr1	156744253	Silent	novel	S133S	0.47
UCEC	chr1	156742526	3'UTR	novel		0.29
UCEC	chr1	156744193	Silent	rs201820242	A153A	0.31
UCEC	chr1	156742766	3'UTR	novel		0.31
UCEC	chr1	156742833	3'UTR	novel		0.47
UCEC	chr1	156745124	Missense_Mutation	novel	L63I	0.43
UCEC	chr1	156742464	3'UTR	novel		0.38
UCEC	chr1	156742564	3'UTR	novel		0.19
UCEC	chr1	156744245	Missense_Mutation	novel	E136G	0.35
UCEC	chr1	156742120	3'UTR	novel		0.13
UCEC	chr1	156743404	3'UTR	novel		0.08
UCEC	chr1	156745312	Frame_Shift_Del	NA	*F50Sfs105**	0.35
UCEC	chr1	156743866	Missense_Mutation	novel	R168C	0.44
UCEC	chr1	156751278	Intron	novel		0.4
UCEC	chr1	156752366	5'Flank	novel		0.54
UCEC	chr1	156743858	Missense_Mutation	novel	K170N	0.44
UCEC	chr1	156742526	3'UTR	novel		0.31
UCEC	chr1	156745320	Silent	novel	V47V	0.22
UCEC	chr1	156742526	3'UTR	novel		0.44
UCEC	chr1	156742234	3'UTR	novel		0.42
UCEC	chr1	156744194	Missense_Mutation	rs757562304	A153V	0.1
UCEC	chr1	156742526	3'UTR	novel		0.45
UCEC	chr1	156742564	3'UTR	novel		0.46
UCEC	chr1	156745311	Frame_Shift_Del	novel	*F50Lfs105**	0.62
UCEC	chr1	156743223	3'UTR	novel		0.24
UCEC	chr1	156743407	3'UTR	novel		0.08
UCEC	chr1	156743671	Missense_Mutation	novel	G233C	0.18
UCEC	chr1	156745143	Silent	novel	A56A	0.31
UCEC	chr1	156742526	3'UTR	novel		0.24
UCEC	chr1	156742992	3'UTR	novel		0.4
UCEC	chr1	156743742	Missense_Mutation	novel	G209E	0.17
UCEC	chr1	156745113	Silent	rs752829566	Y66Y	0.39
UCEC	chr1	156745311	Frame_Shift_Ins	NA	*G51Rfs63**	0.38
UCEC	chr1	156742412	3'UTR	novel		0.39
UCEC	chr1	156742789	3'UTR	novel		0.46
UCEC	chr1	156742885	3'UTR	novel		0.43
UCEC	chr1	156745297	Missense_Mutation	novel	T55M	0.31
UCEC	chr1	156751286	Intron	novel		0.34

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.0208	0.0017831
ESCA	AMP	0.3967	0.0022446
KIRC	AMP	0.0928	0.059566
LGG	AMP	0.0702	0.029503
PAAD	AMP	0.2228	0.085665
READ	AMP	0.2667	0.025154
SKCM	AMP	0.4877	9.6912e-06
TGCT	AMP	0.34	0.088103

Survival Analysis

Cancer	P-value	Q-value
STAD	0.017	Kaplan-Meier Survival Analysis
SARC	0.01	Kaplan-Meier Survival Analysis
MESO	0.011	Kaplan-Meier Survival Analysis
ACC	0.00042	Kaplan-Meier Survival Analysis
SKCM	0.0063	Kaplan-Meier Survival Analysis
PRAD	0.04	Kaplan-Meier Survival Analysis
KIRP	0.0017	Kaplan-Meier Survival Analysis
PAAD	0.0015	Kaplan-Meier Survival Analysis
PCPG	0.045	Kaplan-Meier Survival Analysis
UCEC	0.00042	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.00022	Kaplan-Meier Survival Analysis
UVM	0.0032	Kaplan-Meier Survival Analysis
OV	0.001	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000143321 (Gene tree)
Gene ID: 3068
Gene Symbol: HDGF
Alias: HMG1L2
Full Name: heparin binding growth factor
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 24,819 bases
Position: chr1:156,742,107-156,766,925
Accession: 4856
RBP type: non-canonical RBP
Summary: This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. High levels of expression of this gene enhance the growth of many tumors. This gene was thought initially to be located on chromosome X; however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
22148898	Proteome of the early embryo-maternal dialogue in the cattle uterus.	J Proteome Res	2012 Feb 3	Munoz M	doi: 10.1021/pr200969a

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000368206	HDGF-202	960	-	ENSP00000357189	256 (aa)	-	P51858
ENST00000477306	HDGF-207	686	-	-	- (aa)	-	-
ENST00000495212	HDGF-209	744	-	-	- (aa)	-	-
ENST00000469145	HDGF-205	844	-	-	- (aa)	-	-
ENST00000482651	HDGF-208	966	-	-	- (aa)	-	-
ENST00000357325	HDGF-201	2380	-	ENSP00000349878	240 (aa)	-	P51858
ENST00000368209	HDGF-203	2171	-	ENSP00000357192	233 (aa)	-	P51858
ENST00000465180	HDGF-204	2060	-	-	- (aa)	-	-
ENST00000471377	HDGF-206	592	-	-	- (aa)	-	-
ENST00000537739	HDGF-210	2073	XM_011509453	ENSP00000443120	240 (aa)	XP_011507755	P51858

Gene Model

Click here to download ENSG00000143321's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000143321	rs4399146	1	156743766	G	Blood protein levels	30072576	[0.22-0.32] unit increase	0.269	EFO_0007937

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000143321's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000143321	HDGF	100	85.833	ENSMUSG00000004897	Hdgf	100	85.833	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	19162039.	IDA	Process
GO:0000166	nucleotide binding	-	IEA	Function
GO:0001222	transcription corepressor binding	19162039.	IPI	Function
GO:0003677	DNA binding	-	IEA	Function
GO:0003714	transcription corepressor activity	19162039.	IDA	Function
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005576	extracellular region	27068509.	HDA	Component
GO:0005615	extracellular space	20551380.	HDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	-	IEA	Component
GO:0007165	signal transduction	7929202.	NAS	Process
GO:0008083	growth factor activity	-	IEA	Function
GO:0008201	heparin binding	-	IEA	Function
GO:0008283	cell proliferation	7929202.	TAS	Process
GO:0010469	regulation of signaling receptor activity	-	IEA	Process
GO:0017053	transcriptional repressor complex	19162039.	IDA	Component
GO:0036498	IRE1-mediated unfolded protein response	-	TAS	Process
GO:0062023	collagen-containing extracellular matrix	27559042.	HDA	Component
GO:0098761	cellular response to interleukin-7	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.