Cancer | Chr | Position | Mutation Type | dbSNP | Protein-change | Allele Freq | RBD |
---|---|---|---|---|---|---|---|
BLCA | |||||||
BLCA | |||||||
BLCA | |||||||
BLCA | |||||||
BLCA | |||||||
BLCA | |||||||
BLCA | |||||||
BLCA | |||||||
BLCA | |||||||
BLCA | |||||||
BLCA | |||||||
BRCA | |||||||
BRCA | |||||||
BRCA | |||||||
BRCA | |||||||
BRCA | |||||||
BRCA | |||||||
BRCA | |||||||
BRCA | |||||||
BRCA | |||||||
BRCA | |||||||
BRCA | |||||||
BRCA | |||||||
BRCA | |||||||
BRCA | |||||||
CESC | |||||||
CESC | |||||||
CESC | |||||||
CESC | |||||||
CESC | |||||||
CESC | |||||||
CESC | |||||||
CESC | |||||||
COAD | |||||||
COAD | |||||||
COAD | |||||||
COAD | |||||||
COAD | |||||||
COAD | |||||||
COAD | |||||||
COAD | |||||||
COAD | |||||||
COAD | |||||||
COAD | |||||||
COAD | |||||||
COAD | |||||||
COAD | |||||||
COAD | |||||||
ESCA | |||||||
ESCA | |||||||
GBM | |||||||
GBM | |||||||
GBM | |||||||
GBM | |||||||
GBM | |||||||
HNSC | |||||||
HNSC | |||||||
HNSC | |||||||
HNSC | |||||||
KIRC | |||||||
KIRC | |||||||
KIRC | |||||||
KIRP | |||||||
KIRP | |||||||
LAML | |||||||
LGG | |||||||
LGG | |||||||
LIHC | |||||||
LIHC | |||||||
LIHC | |||||||
LIHC | |||||||
LUAD | |||||||
LUAD | |||||||
LUAD | |||||||
LUAD | |||||||
LUAD | |||||||
LUAD | |||||||
LUAD | |||||||
LUAD | |||||||
LUAD | |||||||
LUAD | |||||||
LUAD | |||||||
LUAD | |||||||
LUSC | |||||||
LUSC | |||||||
LUSC | |||||||
LUSC | |||||||
LUSC | |||||||
LUSC | |||||||
LUSC | |||||||
LUSC | |||||||
LUSC | |||||||
LUSC | |||||||
OV | |||||||
OV | |||||||
OV | |||||||
OV | |||||||
OV | |||||||
PAAD | |||||||
PRAD | |||||||
PRAD | |||||||
PRAD | |||||||
READ | |||||||
READ | |||||||
SARC | |||||||
SARC | |||||||
SARC | |||||||
SKCM | |||||||
SKCM | |||||||
SKCM | |||||||
SKCM | |||||||
SKCM | |||||||
SKCM | |||||||
SKCM | |||||||
SKCM | |||||||
SKCM | |||||||
SKCM | |||||||
SKCM | |||||||
SKCM | |||||||
SKCM | |||||||
SKCM | |||||||
SKCM | |||||||
SKCM | |||||||
SKCM | |||||||
SKCM | |||||||
SKCM | |||||||
STAD | |||||||
STAD | |||||||
STAD | |||||||
STAD | |||||||
STAD | |||||||
STAD | |||||||
STAD | |||||||
STAD | |||||||
STAD | |||||||
STAD | |||||||
STAD | |||||||
STAD | |||||||
STAD | |||||||
STAD | |||||||
STAD | |||||||
STAD | |||||||
STAD | |||||||
STAD | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC | |||||||
UCEC |
Cancer | Type | Freq | Q-value |
---|---|---|---|
ACC | |||
BRCA | |||
CESC | |||
DLBC | |||
ESCA | |||
KIRC | |||
LUSC | |||
PAAD | |||
PCPG | |||
READ | |||
SARC | |||
SKCM | |||
STAD | |||
TGCT | |||
UCEC |
Cancer | P-value | Q-value |
---|---|---|
KIRC | ||
STAD | ||
SKCM | ||
PCPG | ||
KICH | ||
UCEC | ||
UVM |
Protein ID | Domain | Pfam ID | E-value | Domain number | Total number |
---|---|---|---|---|---|
ENSP00000358060 | tRNA_SAD | PF07973.14 | 2.1e-08 | 1 | 1 |
ENSP00000475847 | tRNA_SAD | PF07973.14 | 5.4e-07 | 1 | 1 |
ENSP00000415002 | tRNA_SAD | PF07973.14 | 3.1e-06 | 1 | 1 |
ENSP00000415002 | HGTP_anticodon | PF03129.20 | 9.9e-19 | 1 | 1 |
ENSP00000358050 | HGTP_anticodon | PF03129.20 | 1.2e-18 | 1 | 1 |
ENSP00000475847 | HGTP_anticodon | PF03129.20 | 1.4e-18 | 1 | 1 |
ENSP00000358060 | HGTP_anticodon | PF03129.20 | 1.6e-18 | 1 | 1 |
ENSP00000415002 | tRNA-synt_2b | PF00587.25 | 2.7e-33 | 1 | 1 |
ENSP00000358050 | tRNA-synt_2b | PF00587.25 | 5e-33 | 1 | 1 |
ENSP00000475847 | tRNA-synt_2b | PF00587.25 | 5.4e-33 | 1 | 1 |
ENSP00000358060 | tRNA-synt_2b | PF00587.25 | 7e-33 | 1 | 1 |
PID | Title | Method | Time | Author | Doi |
---|---|---|---|---|---|
30607034 |
Transcript ID | Name | Length | RefSeq ID | Protein ID | Length | RefSeq ID | UniportKB ID |
---|---|---|---|---|---|---|---|
ENST00000369051 | TARS2-201 | 2106 | - | ENSP00000358047 | 135 (aa) | - | Q5T5E9 |
ENST00000480070 | TARS2-212 | 832 | - | - | - (aa) | - | - |
ENST00000369053 | TARS2-202 | 628 | - | - | - (aa) | - | - |
ENST00000369054 | TARS2-203 | 1998 | - | ENSP00000358050 | 588 (aa) | - | Q9BW92 |
ENST00000462578 | TARS2-207 | 609 | - | - | - (aa) | - | - |
ENST00000606933 | TARS2-214 | 2162 | XM_017002395 | ENSP00000475847 | 636 (aa) | XP_016857884 | U3KQG0 |
ENST00000438568 | TARS2-205 | 2188 | - | ENSP00000415002 | 443 (aa) | - | F6S7Q7 |
ENST00000463555 | TARS2-208 | 852 | - | - | - (aa) | - | - |
ENST00000467982 | TARS2-210 | 1855 | - | ENSP00000475551 | 143 (aa) | - | U3KQ50 |
ENST00000466989 | TARS2-209 | 427 | - | - | - (aa) | - | - |
ENST00000369064 | TARS2-204 | 2729 | XM_006711555 | ENSP00000358060 | 718 (aa) | XP_006711618 | Q9BW92 |
ENST00000479372 | TARS2-211 | 850 | - | - | - (aa) | - | - |
ENST00000483046 | TARS2-213 | 311 | - | - | - (aa) | - | - |
ENST00000460794 | TARS2-206 | 568 | - | - | - (aa) | - | - |
Pathway ID | Pathway Name | Source |
---|---|---|
hsa00970 | Aminoacyl-tRNA biosynthesis | KEGG |
ensgID | Trait | pValue | Pubmed ID |
---|---|---|---|
ENSG00000143374 | Cerebrospinal Fluid | 2E-10 | 28031287 |
ensgID | SNP | Chromosome | Position | SNP-risk | Trait | PubmedID | 95% CI | Or or BEAT | EFO ID |
---|---|---|---|---|---|---|---|---|---|
ENSG00000143374 | rs3754214 | 1 | 150506147 | ? | Cerebrospinal fluid biomarker levels | 28031287 | EFO_0006794 | ||
ENSG00000143374 | rs9436119 | 1 | 150495277 | A | Chronotype | 30696823 | 1.0402905 | EFO_0008328 | |
ENSG00000143374 | rs9436119 | 1 | 150495277 | A | Morning person | 30696823 | 1.041 | EFO_0008328 |
Ensembl ID | Gene Symbol | Coverage | Identiy | Paralog | Gene Symbol | Coverage | Identiy |
---|---|---|---|---|---|---|---|
ENSG00000143374 | TARS2 | 96 | 55.759 | ENSG00000185418 | TARSL2 | 97 | 57.639 |
ENSG00000143374 | TARS2 | 96 | 57.552 | ENSG00000113407 | TARS | 93 | 54.124 |
Ensembl ID | Gene Symbol | Coverage | Identiy | Ortholog | Gene Symbol | Coverage | Identiy | Species |
---|---|---|---|---|---|---|---|---|
ENSG00000143374 | TARS2 | 100 | 87.656 | ENSAMEG00000001547 | TARS2 | 100 | 87.656 | Ailuropoda_melanoleuca |
ENSG00000143374 | TARS2 | 100 | 95.125 | ENSANAG00000019620 | TARS2 | 100 | 95.125 | Aotus_nancymaae |
ENSG00000143374 | TARS2 | 100 | 88.022 | ENSBTAG00000003799 | TARS2 | 100 | 88.022 | Bos_taurus |
ENSG00000143374 | TARS2 | 100 | 94.969 | ENSCJAG00000006429 | TARS2 | 100 | 94.969 | Callithrix_jacchus |
ENSG00000143374 | TARS2 | 100 | 87.467 | ENSCAFG00000011941 | TARS2 | 100 | 87.326 | Canis_familiaris |
ENSG00000143374 | TARS2 | 100 | 87.467 | ENSCAFG00020019615 | TARS2 | 100 | 87.326 | Canis_lupus_dingo |
ENSG00000143374 | TARS2 | 100 | 88.022 | ENSCHIG00000018559 | TARS2 | 100 | 88.022 | Capra_hircus |
ENSG00000143374 | TARS2 | 100 | 91.922 | ENSTSYG00000003903 | TARS2 | 100 | 92.095 | Carlito_syrichta |
ENSG00000143374 | TARS2 | 100 | 94.290 | ENSCCAG00000034305 | TARS2 | 100 | 94.290 | Cebus_capucinus |
ENSG00000143374 | TARS2 | 100 | 96.769 | ENSCATG00000034784 | TARS2 | 100 | 96.769 | Cercocebus_atys |
ENSG00000143374 | TARS2 | 98 | 84.615 | ENSCLAG00000017274 | TARS2 | 100 | 86.207 | Chinchilla_lanigera |
ENSG00000143374 | TARS2 | 98 | 100.000 | ENSCSAG00000018075 | TARS2 | 100 | 97.354 | Chlorocebus_sabaeus |
ENSG00000143374 | TARS2 | 72 | 88.350 | ENSCHOG00000000796 | - | 82 | 87.402 | Choloepus_hoffmanni |
ENSG00000143374 | TARS2 | 84 | 95.135 | ENSCANG00000035036 | TARS2 | 94 | 95.135 | Colobus_angolensis_palliatus |
ENSG00000143374 | TARS2 | 100 | 84.371 | ENSCGRG00001023517 | Tars2 | 100 | 86.614 | Cricetulus_griseus_chok1gshd |
ENSG00000143374 | TARS2 | 100 | 84.371 | ENSCGRG00000007836 | Tars2 | 100 | 86.614 | Cricetulus_griseus_crigri |
ENSG00000143374 | TARS2 | 100 | 87.744 | ENSDNOG00000005934 | TARS2 | 100 | 87.744 | Dasypus_novemcinctus |
ENSG00000143374 | TARS2 | 91 | 81.888 | ENSDORG00000007569 | Tars2 | 99 | 89.362 | Dipodomys_ordii |
ENSG00000143374 | TARS2 | 98 | 88.462 | ENSETEG00000008569 | TARS2 | 100 | 79.387 | Echinops_telfairi |
ENSG00000143374 | TARS2 | 100 | 89.817 | ENSEASG00005001587 | TARS2 | 100 | 88.997 | Equus_asinus_asinus |
ENSG00000143374 | TARS2 | 100 | 90.339 | ENSECAG00000014276 | TARS2 | 100 | 89.276 | Equus_caballus |
ENSG00000143374 | TARS2 | 89 | 86.592 | ENSEEUG00000000186 | - | 78 | 86.592 | Erinaceus_europaeus |
ENSG00000143374 | TARS2 | 100 | 88.095 | ENSFCAG00000001702 | TARS2 | 100 | 88.142 | Felis_catus |
ENSG00000143374 | TARS2 | 100 | 81.723 | ENSFDAG00000012739 | TARS2 | 100 | 83.629 | Fukomys_damarensis |
ENSG00000143374 | TARS2 | 100 | 94.183 | ENSGGOG00000006311 | TARS2 | 100 | 100.000 | Gorilla_gorilla |
ENSG00000143374 | TARS2 | 100 | 81.241 | ENSHGLG00000009219 | TARS2 | 100 | 82.011 | Heterocephalus_glaber_female |
ENSG00000143374 | TARS2 | 100 | 81.241 | ENSHGLG00100008254 | TARS2 | 100 | 81.379 | Heterocephalus_glaber_male |
ENSG00000143374 | TARS2 | 100 | 87.467 | ENSSTOG00000008311 | TARS2 | 100 | 89.567 | Ictidomys_tridecemlineatus |
ENSG00000143374 | TARS2 | 100 | 83.862 | ENSJJAG00000021883 | Tars2 | 100 | 85.433 | Jaculus_jaculus |
ENSG00000143374 | TARS2 | 100 | 86.842 | ENSLAFG00000004979 | TARS2 | 100 | 86.842 | Loxodonta_africana |
ENSG00000143374 | TARS2 | 98 | 100.000 | ENSMFAG00000030387 | TARS2 | 98 | 100.000 | Macaca_fascicularis |
ENSG00000143374 | TARS2 | 98 | 100.000 | ENSMMUG00000006256 | TARS2 | 98 | 100.000 | Macaca_mulatta |
ENSG00000143374 | TARS2 | 88 | 96.923 | ENSMNEG00000042066 | TARS2 | 90 | 96.923 | Macaca_nemestrina |
ENSG00000143374 | TARS2 | 98 | 100.000 | ENSMLEG00000030174 | TARS2 | 98 | 100.000 | Mandrillus_leucophaeus |
ENSG00000143374 | TARS2 | 93 | 59.466 | ENSMGAG00000000718 | TARS2 | 100 | 60.102 | Meleagris_gallopavo |
ENSG00000143374 | TARS2 | 100 | 83.812 | ENSMAUG00000008184 | Tars2 | 99 | 88.571 | Mesocricetus_auratus |
ENSG00000143374 | TARS2 | 100 | 89.524 | ENSMICG00000008016 | TARS2 | 100 | 90.119 | Microcebus_murinus |
ENSG00000143374 | TARS2 | 100 | 84.856 | ENSMOCG00000018432 | Tars2 | 100 | 87.205 | Microtus_ochrogaster |
ENSG00000143374 | TARS2 | 91 | 84.615 | ENSMODG00000018792 | TARS2 | 99 | 74.334 | Monodelphis_domestica |
ENSG00000143374 | TARS2 | 100 | 83.541 | MGP_CAROLIEiJ_G0025352 | Tars2 | 99 | 92.143 | Mus_caroli |
ENSG00000143374 | TARS2 | 100 | 83.679 | ENSMUSG00000028107 | Tars2 | 99 | 90.714 | Mus_musculus |
ENSG00000143374 | TARS2 | 100 | 82.988 | MGP_PahariEiJ_G0026796 | Tars2 | 99 | 91.429 | Mus_pahari |
ENSG00000143374 | TARS2 | 100 | 83.541 | MGP_SPRETEiJ_G0026296 | Tars2 | 99 | 90.714 | Mus_spretus |
ENSG00000143374 | TARS2 | 100 | 88.488 | ENSMPUG00000004795 | TARS2 | 100 | 88.488 | Mustela_putorius_furo |
ENSG00000143374 | TARS2 | 100 | 87.933 | ENSMLUG00000013123 | TARS2 | 100 | 87.933 | Myotis_lucifugus |
ENSG00000143374 | TARS2 | 100 | 98.571 | ENSNLEG00000009858 | TARS2 | 100 | 98.571 | Nomascus_leucogenys |
ENSG00000143374 | TARS2 | 91 | 84.615 | ENSMEUG00000014226 | TARS2 | 99 | 69.986 | Notamacropus_eugenii |
ENSG00000143374 | TARS2 | 93 | 84.127 | ENSOPRG00000010194 | TARS2 | 86 | 85.301 | Ochotona_princeps |
ENSG00000143374 | TARS2 | 100 | 82.621 | ENSODEG00000011883 | TARS2 | 100 | 84.252 | Octodon_degus |
ENSG00000143374 | TARS2 | 100 | 85.446 | ENSOGAG00000005360 | TARS2 | 100 | 74.480 | Otolemur_garnettii |
ENSG00000143374 | TARS2 | 100 | 87.535 | ENSOARG00000020814 | TARS2 | 100 | 87.535 | Ovis_aries |
ENSG00000143374 | TARS2 | 100 | 100.000 | ENSPPAG00000042011 | TARS2 | 100 | 100.000 | Pan_paniscus |
ENSG00000143374 | TARS2 | 100 | 87.831 | ENSPPRG00000019975 | TARS2 | 100 | 87.747 | Panthera_pardus |
ENSG00000143374 | TARS2 | 100 | 87.566 | ENSPTIG00000008079 | TARS2 | 100 | 86.907 | Panthera_tigris_altaica |
ENSG00000143374 | TARS2 | 100 | 100.000 | ENSPTRG00000001256 | TARS2 | 100 | 100.000 | Pan_troglodytes |
ENSG00000143374 | TARS2 | 98 | 100.000 | ENSPANG00000016774 | TARS2 | 98 | 100.000 | Papio_anubis |
ENSG00000143374 | TARS2 | 99 | 77.285 | ENSPCIG00000008884 | TARS2 | 99 | 74.895 | Phascolarctos_cinereus |
ENSG00000143374 | TARS2 | 100 | 98.607 | ENSPPYG00000000898 | TARS2 | 100 | 98.607 | Pongo_abelii |
ENSG00000143374 | TARS2 | 92 | 78.635 | ENSPCAG00000016619 | TARS2 | 100 | 73.991 | Procavia_capensis |
ENSG00000143374 | TARS2 | 100 | 91.667 | ENSPCOG00000017247 | TARS2 | 100 | 91.667 | Propithecus_coquereli |
ENSG00000143374 | TARS2 | 100 | 88.372 | ENSPVAG00000004340 | TARS2 | 100 | 83.148 | Pteropus_vampyrus |
ENSG00000143374 | TARS2 | 100 | 82.573 | ENSRNOG00000057194 | Tars2 | 100 | 82.573 | Rattus_norvegicus |
ENSG00000143374 | TARS2 | 100 | 96.084 | ENSRBIG00000044518 | TARS2 | 100 | 96.084 | Rhinopithecus_bieti |
ENSG00000143374 | TARS2 | 98 | 100.000 | ENSRROG00000030946 | TARS2 | 98 | 100.000 | Rhinopithecus_roxellana |
ENSG00000143374 | TARS2 | 97 | 93.211 | ENSSBOG00000001108 | TARS2 | 100 | 93.211 | Saimiri_boliviensis_boliviensis |
ENSG00000143374 | TARS2 | 93 | 84.615 | ENSSHAG00000010286 | TARS2 | 100 | 76.341 | Sarcophilus_harrisii |
ENSG00000143374 | TARS2 | 98 | 79.772 | ENSSARG00000013133 | TARS2 | 100 | 79.358 | Sorex_araneus |
ENSG00000143374 | TARS2 | 91 | 89.817 | ENSSSCG00000026395 | TARS2 | 99 | 89.238 | Sus_scrofa |
ENSG00000143374 | TARS2 | 82 | 85.417 | ENSTBEG00000003968 | TARS2 | 82 | 85.417 | Tupaia_belangeri |
ENSG00000143374 | TARS2 | 85 | 90.741 | ENSTTRG00000010627 | TARS2 | 80 | 90.741 | Tursiops_truncatus |
ENSG00000143374 | TARS2 | 93 | 87.500 | ENSUAMG00000023983 | TARS2 | 95 | 88.571 | Ursus_americanus |
ENSG00000143374 | TARS2 | 100 | 88.773 | ENSUMAG00000003705 | TARS2 | 100 | 88.579 | Ursus_maritimus |
ENSG00000143374 | TARS2 | 85 | 87.069 | ENSVPAG00000005427 | TARS2 | 74 | 87.069 | Vicugna_pacos |
ENSG00000143374 | TARS2 | 100 | 87.728 | ENSVVUG00000009226 | TARS2 | 100 | 86.963 | Vulpes_vulpes |
Go ID | Go_term | PubmedID | Evidence | Category |
---|---|---|---|---|
GO:0002161 | aminoacyl-tRNA editing activity | 26811336. | IDA | Function |
GO:0004829 | threonine-tRNA ligase activity | 21873635. | IBA | Function |
GO:0004829 | threonine-tRNA ligase activity | 26811336. | IDA | Function |
GO:0005524 | ATP binding | - | IEA | Function |
GO:0005575 | cellular_component | - | ND | Component |
GO:0005737 | cytoplasm | 21873635. | IBA | Component |
GO:0005759 | mitochondrial matrix | - | IEA | Component |
GO:0006435 | threonyl-tRNA aminoacylation | 21873635. | IBA | Process |
GO:0042803 | protein homodimerization activity | 26811336. | IDA | Function |
GO:0070159 | mitochondrial threonyl-tRNA aminoacylation | 15779907. | TAS | Process |
GO:0106074 | aminoacyl-tRNA metabolism involved in translational fidelity | - | IEA | Process |