EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26059795	Upregulated expression of ILF2 in non-small cell lung cancer is associated with tumor cell proliferation and poor prognosis.	J Mol Histol	2015 Oct	Ni T	doi: 10.1007/s10735-015-9624-5
28831206	Expression and Clinical Significance of ILF2 in Gastric Cancer.	Dis Markers	2017	Yin ZH	doi: 10.1155/2017/4387081

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr1	153670963	5'UTR	novel		0.3
BLCA	chr1	153663262	Silent	novel	V253V	0.28
BLCA	chr1	153665666	Missense_Mutation	NA	E153K	0.05
BLCA	chr1	153662295	3'UTR	novel		0.14
BLCA	chr1	153662419	Missense_Mutation	novel	E384K	0.13
BLCA	chr1	153662303	3'UTR	novel		0.2
BLCA	chr1	153662434	Missense_Mutation	novel	Q379E	0.3
BRCA	chr1	153662780	Missense_Mutation	novel	T313A	0.27
BRCA	chr1	153662399	Missense_Mutation	NA	E390D	0.18
BRCA	chr1	153662545	Nonsense_Mutation	NA	E342*	0.17
BRCA	chr1	153662324	3'UTR	novel		0.43
BRCA	chr1	153663030	Missense_Mutation	NA	L304I	0.35
BRCA	chr1	153662363	3'UTR	rs755571710		0.16
BRCA	chr1	153668547	Missense_Mutation	novel	A40V	0.09
BRCA	chr1	153663050	Missense_Mutation	NA	R297T	0.17
BRCA	chr1	153664062	Missense_Mutation	rs767092802	P242L	0.22
CESC	chr1	153665316	Missense_Mutation	rs768322800	E161K	0.29
CESC	chr1	153664408	Missense_Mutation	novel	A215V	0.36
CESC	chr1	153662066	3'UTR	novel		0.38
COAD	chr1	153670931	5'UTR	novel		0.59
COAD	chr1	153662414	Missense_Mutation	NA	S385R	0.19
COAD	chr1	153670951	5'UTR	novel		0.27
COAD	chr1	153665339	Splice_Region	rs756450269		0.31
COAD	chr1	153665304	Missense_Mutation	NA	E165K	0.26
GBM	chr1	153664116	In_Frame_Ins	novel	I224delinsKL	0.07
GBM	chr1	153670949	5'UTR	novel		0.44
GBM	chr1	153662461	Missense_Mutation	novel	E370K	0.26
GBM	chr1	153670953	5'UTR	novel		0.29
HNSC	chr1	153670224	Silent	novel	D4D	0.23
HNSC	chr1	153662436	Missense_Mutation	novel	P378R	0.42
HNSC	chr1	153667628	Silent	novel	S107S	0.12
KIRP	chr1	153662319	3'UTR	novel		0.29
KIRP	chr1	153664107	Missense_Mutation	novel	L227P	0.36
KIRP	chr1	153664108	Silent	novel	L227L	0.36
LAML	chr1	153664474	Missense_Mutation	novel	L193W	0.06
LGG	chr1	153670981	5'UTR	novel		0.06
LGG	chr1	153665291	Missense_Mutation	novel	S169F	0.35
LUAD	chr1	153662754	Silent	NA	L321L	0.2
LUAD	chr1	153668021	Silent	NA	V90V	0.29
LUAD	chr1	153664128	Missense_Mutation	novel	V220A	0.29
LUAD	chr1	153670222	Missense_Mutation	NA	R5T	0.1
LUAD	chr1	153668530	Missense_Mutation	novel	P46A	0.08
LUAD	chr1	153664451	Missense_Mutation	novel	A201T	0.11
LUSC	chr1	153662707	Missense_Mutation	novel	S337N	0.18
LUSC	chr1	153662320	3'UTR	novel		0.15
LUSC	chr1	153665262	Missense_Mutation	novel	T179A	0.27
LUSC	chr1	153662714	Missense_Mutation	novel	D335N	0.44
LUSC	chr1	153664075	Missense_Mutation	novel	E238Q	0.41
LUSC	chr1	153670951	5'UTR	novel		0.37
OV	chr1	153662152	3'UTR	novel		0.47
OV	chr1	153668480	Missense_Mutation	novel	Q62H	0.11
OV	chr1	153667621	Missense_Mutation	novel	K110E	0.45	DZF
PAAD	chr1	153669865	Missense_Mutation	novel	V27I	0.15
PRAD	chr1	153663213	Splice_Site	novel	X269_splice	0.15
PRAD	chr1	153663018	Splice_Site	novel	X307_splice	0.37
READ	chr1	153664419	Silent	rs552124279	F211F	0.34
SARC	chr1	153662307	3'UTR	novel		0.11
SKCM	chr1	153664401	Missense_Mutation	NA	Q217H	0.27
SKCM	chr1	153662271	3'UTR	novel		0.44
SKCM	chr1	153664092	Missense_Mutation	NA	I232T	0.23
SKCM	chr1	153671002	5'UTR	NA		0.35
STAD	chr1	153668015	Silent	NA	P92P	0.34
STAD	chr1	153665722	Missense_Mutation	NA	A134V	0.22	DZF
STAD	chr1	153670232	Splice_Site	NA	X2_splice	0.23
UCEC	chr1	153664424	Missense_Mutation	NA	W210G	0.26
UCEC	chr1	153663062	Missense_Mutation	novel	S293I	0.1
UCEC	chr1	153668019	Missense_Mutation	novel	A91V	0.2
UCEC	chr1	153670915	Splice_Region	novel		0.41
UCEC	chr1	153663132	Missense_Mutation	novel	R270C	0.48
UCEC	chr1	153665663	Missense_Mutation	NA	V154F	0.49
UCEC	chr1	153662307	3'UTR	novel		0.05
UCEC	chr1	153664090	Missense_Mutation	rs763025203	R233C	0.12
UCEC	chr1	153670175	Nonsense_Mutation	novel	G21*	0.11
UCEC	chr1	153662408	Missense_Mutation	novel	E387D	0.36
UCEC	chr1	153662761	Missense_Mutation	novel	R319Q	0.24
UCEC	chr1	153670188	Silent	novel	R16R	0.4
UCEC	chr1	153662502	Frame_Shift_Del	novel	*K356Rfs68**	0.1
UCEC	chr1	153662161	3'UTR	novel		0.43
UCEC	chr1	153669842	Missense_Mutation	novel	F34L	0.35
UCEC	chr1	153662069	3'UTR	novel		0.78
UCEC	chr1	153667637	Missense_Mutation	novel	Q104H	0.31	DZF
UCEC	chr1	153669865	Missense_Mutation	novel	V27I	0.19
UCEC	chr1	153667642	Nonsense_Mutation	NA	R103*	0.45
UCEC	chr1	153667642	Nonsense_Mutation	NA	R103*	0.36
UCEC	chr1	153663056	Missense_Mutation	novel	N295S	0.4
UCEC	chr1	153664132	Splice_Site	novel	X219_splice	0.25

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	AMP	0.1444	0.11282
CESC	AMP	0.4814	3.2002e-05
DLBC	DEL	0.0417	0.0017831
ESCA	AMP	0.413	0.0022446
KIRC	AMP	0.0928	0.059566
PAAD	AMP	0.2228	0.085665
PCPG	AMP	0.1543	0.00029562
PRAD	AMP	0.0732	0.00077815
READ	AMP	0.2667	0.025154
SARC	AMP	0.3502	4.3422e-08
SKCM	AMP	0.4877	9.6912e-06
TGCT	AMP	0.3533	0.088103

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0032	Kaplan-Meier Survival Analysis
KIRC	0.0054	Kaplan-Meier Survival Analysis
SARC	0.00011	Kaplan-Meier Survival Analysis
MESO	0.0039	Kaplan-Meier Survival Analysis
ACC	0.00011	Kaplan-Meier Survival Analysis
ESCA	0.03	Kaplan-Meier Survival Analysis
KIRP	0.024	Kaplan-Meier Survival Analysis
PCPG	0.042	Kaplan-Meier Survival Analysis
KICH	0.03	Kaplan-Meier Survival Analysis
UCEC	0.02	Kaplan-Meier Survival Analysis
GBM	0.0067	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
DLBC	0.0083	Kaplan-Meier Survival Analysis
UVM	0.019	Kaplan-Meier Survival Analysis
OV	0.0057	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000143621 (Gene tree)
Gene ID: 3608
Gene Symbol: ILF2
Alias: NF45
Full Name: interleukin enhancer binding factor 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 9,261 bases
Position: chr1:153,661,788-153,671,048
Accession: 6037
RBP type: canonical RBP
Summary: The protein encoded by this gene is a transcription factor required for T-cell expression of the interleukin 2 gene. It also binds RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. The encoded 45 kDa protein (NF45, ILF2) forms a complex with the 90 kDa interleukin enhancer-binding factor 3 (NF90, ILF3), and this complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm, to repair DNA breaks by nonhomologous end joining, and to negatively regulate the microRNA processing pathway. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. Alternative splicing results in multiple transcript variants. Related pseudogenes have been found on chromosomes 3 and 14. [provided by RefSeq, Dec 2014]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000482909	DZF	PF07528.14	6.1e-95	1	1
ENSP00000355011	DZF	PF07528.14	8.3e-95	1	1
ENSP00000357673	DZF	PF07528.14	1.8e-11	1	1
ENSP00000357670	DZF	PF07528.14	4.1e-06	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
22833610	NF45 dimerizes with NF90, Zfr and SPNR via a conserved domain that has a nucleotidyltransferase fold.	Nucleic Acids Res	2012 Oct	Wolkowicz UM	doi: 10.1093/nar/gks696
21386893	NF90 binds the dengue virus RNA 3' terminus and is a positive regulator of dengue virus replication.	PLoS One	2011 Feb 28	Gomila RC	doi: 10.1371/journal.pone.0016687.
20112001	Characterization of proteins associating with 5' terminus of PGHS-1 mRNA.	Cell Mol Biol Lett	2010 Jun	Bunimov N	doi: 10.2478/s11658-010-0005-5
26240280	The NF45/NF90 Heterodimer Contributes to the Biogenesis of 60S Ribosomal Subunits and Influences Nucleolar Morphology.	Mol Cell Biol	2015 Oct	Wandrey F	doi: 10.1128/MCB.00306-15
11438540	Nuclear factor 90 is a substrate and regulator of the eukaryotic initiation factor 2 kinase double-stranded RNA-activated protein kinase.	J Biol Chem	2001 Aug 31	Parker LM	-
21439385	An interleukin-2 enhancer binding factor 2 homolog involved in immune response from Chinese mitten crab Eriocheir sinensis.	Fish Shellfish Immunol	2011 Jun	Yang J	doi: 10.1016/j.fsi.2011.03.014
29040738	NF90-NF45 is a selective RNA chaperone that rearranges viral and cellular riboswitches: biochemical analysis of a virus host factor activity.	Nucleic Acids Res	2017 Dec 1	Schmidt T	doi: 10.1093/nar/gkx931.
30060955	A negative feedback loop between nuclear factor 90 (NF90) and an anti-oncogenic microRNA, miR-7.	Biochem Biophys Res Commun	2018 Sep 10	Higuchi T	doi: 10.1016/j.bbrc.2018.07.119
10931159	Widespread susceptibility among inbred mouse strains to the induction of lupus autoantibodies by pristane.	Clin Exp Immunol	2000 Aug	Satoh M	-
16809299	The double-stranded RNA binding protein 76:NF45 heterodimer inhibits translation initiation at the rhinovirus type 2 internal ribosome entry site.	J Virol	2006 Jul	Merrill MK	-
19893574	NF45 functions as an IRES trans-acting factor that is required for translation of cIAP1 during the unfolded protein response.	Cell Death Differ	2010 Apr	Graber TE	doi: 10.1038/cdd.2009.164
18458058	Nuclear factor 45 (NF45) is a regulatory subunit of complexes with NF90/110 involved in mitotic control.	Mol Cell Biol	2008 Jul	Guan D	doi: 10.1128/MCB.00120-08
21969602	The NF90/NF45 complex participates in DNA break repair via nonhomologous end joining.	Mol Cell Biol	2011 Dec	Shamanna RA	doi: 10.1128/MCB.05849-11
28062840	The properties of the RNA-binding protein NF90 are considerably modulated by complex formation with NF45.	Biochem J	2017 Jan 15	Schmidt T	doi: 10.1042/BCJ20160790
26891316	NF45 and NF90 Bind HIV-1 RNA and Modulate HIV Gene Expression.	Viruses	2016 Feb 16	Li Y	doi: 10.3390/v8020047.
26381409	The RNA binding complexes NF45-NF90 and NF45-NF110 associate dynamically with the c-fos gene and function as transcriptional coactivators.	J Biol Chem	2015 Oct 30	Nakadai T	doi: 10.1074/jbc.M115.688317
29930005	Diabetes Mellitus-Induced Long Noncoding RNA Dnm3os Regulates Macrophage Functions and Inflammation via Nuclear Mechanisms.	Arterioscler Thromb Vasc Biol	2018 Aug	Das S	doi: 10.1161/ATVBAHA.117.310663.
22504300	Synthetic oligonucleotides recruit ILF2/3 to RNA transcripts to modulate splicing.	Nat Chem Biol	2012 Apr 15	Rigo F	doi: 10.1038/nchembio.939.
24920670	RNA granule assembly and disassembly modulated by nuclear factor associated with double-stranded RNA 2 and nuclear factor 45.	J Biol Chem	2014 Jul 25	Shiina N	-
26579211	RNA:DNA hybrids in the human genome have distinctive nucleotide characteristics, chromatin composition, and transcriptional relationships.	Epigenetics Chromatin	2015 Nov 16	Nadel J	doi: 10.1186/s13072-015-0040-6
30018709	Interleukin enhancer binding factor 2 is a prognostic biomarker for breast cancer that also predicts neoadjuvant chemotherapy responses.	Am J Transl Res	2018 Jun 15	Jin Z	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000480213	ILF2-204	1008	-	-	- (aa)	-	-
ENST00000368681	ILF2-202	726	-	ENSP00000357670	150 (aa)	-	A0A0A0MRL0
ENST00000615950	ILF2-205	1906	-	ENSP00000482909	352 (aa)	-	B4DY09
ENST00000368684	ILF2-203	476	-	ENSP00000357673	115 (aa)	-	X6R6Z1
ENST00000361891	ILF2-201	1659	-	ENSP00000355011	390 (aa)	-	Q12905

Gene Model

Click here to download ENSG00000143621's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000143621	Multiple Myeloma	4E-6	23502783
ENSG00000143621	Multiple Myeloma	9E-6	23502783

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000143621	rs7536700	1	153668351	A	Multiple myeloma (IgH translocation)	23502783	[1.28-1.84]	1.53	EFO_0001378
ENSG00000143621	rs7536700	1	153668351	A	Multiple myeloma (IgH translocation)	23502783	[1.42-2.46]	1.86	EFO_0001378

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000143621's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000143621	ILF2	61	30.544	ENSG00000129351	ILF3	64	33.333

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000143621	ILF2	100	92.174	ENSAPOG00000009781	ilf2	92	92.812	Acanthochromis_polyacanthus
ENSG00000143621	ILF2	100	99.432	ENSAMEG00000012155	ILF2	99	99.486	Ailuropoda_melanoleuca
ENSG00000143621	ILF2	100	89.565	ENSACIG00000013471	ilf2	92	92.188	Amphilophus_citrinellus
ENSG00000143621	ILF2	100	91.304	ENSAOCG00000018379	ilf2	86	92.470	Amphiprion_ocellaris
ENSG00000143621	ILF2	100	91.304	ENSAPEG00000017042	ilf2	86	92.470	Amphiprion_percula
ENSG00000143621	ILF2	100	91.304	ENSATEG00000013505	ilf2	86	92.470	Anabas_testudineus
ENSG00000143621	ILF2	100	92.174	ENSAPLG00000016146	ILF2	92	95.783	Anas_platyrhynchos
ENSG00000143621	ILF2	100	100.000	ENSANAG00000007295	-	100	100.000	Aotus_nancymaae
ENSG00000143621	ILF2	100	81.795	ENSANAG00000038483	-	85	80.723	Aotus_nancymaae
ENSG00000143621	ILF2	100	91.304	ENSACLG00000017159	ilf2	83	92.771	Astatotilapia_calliptera
ENSG00000143621	ILF2	100	91.304	ENSAMXG00000010896	ilf2	86	93.072	Astyanax_mexicanus
ENSG00000143621	ILF2	100	100.000	ENSBTAG00000012471	ILF2	100	100.000	Bos_taurus
ENSG00000143621	ILF2	94	72.222	ENSBTAG00000048543	-	84	65.680	Bos_taurus
ENSG00000143621	ILF2	88	36.927	WBGene00011253	R11H6.5	80	37.898	Caenorhabditis_elegans
ENSG00000143621	ILF2	100	100.000	ENSCJAG00000010264	ILF2	100	100.000	Callithrix_jacchus
ENSG00000143621	ILF2	100	100.000	ENSCAFG00000017530	ILF2	99	100.000	Canis_familiaris
ENSG00000143621	ILF2	100	100.000	ENSCAFG00020010294	ILF2	100	96.401	Canis_lupus_dingo
ENSG00000143621	ILF2	100	100.000	ENSCHIG00000012048	ILF2	100	100.000	Capra_hircus
ENSG00000143621	ILF2	100	100.000	ENSTSYG00000012061	ILF2	100	100.000	Carlito_syrichta
ENSG00000143621	ILF2	88	79.221	ENSTSYG00000028407	-	77	92.126	Carlito_syrichta
ENSG00000143621	ILF2	100	100.000	ENSCPOG00000005835	ILF2	100	99.744	Cavia_porcellus
ENSG00000143621	ILF2	100	100.000	ENSCCAG00000021436	ILF2	100	100.000	Cebus_capucinus
ENSG00000143621	ILF2	100	100.000	ENSCATG00000045233	ILF2	100	100.000	Cercocebus_atys
ENSG00000143621	ILF2	100	100.000	ENSCLAG00000003140	ILF2	100	100.000	Chinchilla_lanigera
ENSG00000143621	ILF2	100	75.652	ENSCSAG00000011762	-	85	80.363	Chlorocebus_sabaeus
ENSG00000143621	ILF2	100	100.000	ENSCSAG00000019000	-	100	98.718	Chlorocebus_sabaeus
ENSG00000143621	ILF2	100	100.000	ENSCSAG00000001866	-	99	100.000	Chlorocebus_sabaeus
ENSG00000143621	ILF2	92	75.926	ENSCHOG00000003310	ILF2	85	76.506	Choloepus_hoffmanni
ENSG00000143621	ILF2	100	98.261	ENSCPBG00000025410	ILF2	100	97.443	Chrysemys_picta_bellii
ENSG00000143621	ILF2	95	59.941	ENSCING00000003447	nf45	90	61.261	Ciona_intestinalis
ENSG00000143621	ILF2	91	58.592	ENSCSAVG00000007064	-	86	59.159	Ciona_savignyi
ENSG00000143621	ILF2	100	100.000	ENSCANG00000012992	ILF2	100	100.000	Colobus_angolensis_palliatus
ENSG00000143621	ILF2	100	87.826	ENSCGRG00001012241	-	84	85.843	Cricetulus_griseus_chok1gshd
ENSG00000143621	ILF2	100	100.000	ENSCGRG00001009622	-	100	100.000	Cricetulus_griseus_chok1gshd
ENSG00000143621	ILF2	100	87.826	ENSCGRG00000007545	-	84	85.843	Cricetulus_griseus_crigri
ENSG00000143621	ILF2	100	100.000	ENSCGRG00000007660	-	100	100.000	Cricetulus_griseus_crigri
ENSG00000143621	ILF2	100	92.174	ENSCSEG00000018437	ilf2	86	92.470	Cynoglossus_semilaevis
ENSG00000143621	ILF2	100	90.435	ENSCVAG00000018474	ilf2	99	88.502	Cyprinodon_variegatus
ENSG00000143621	ILF2	100	90.435	ENSDARG00000014591	ilf2	86	91.566	Danio_rerio
ENSG00000143621	ILF2	100	71.591	ENSDNOG00000033116	-	85	71.386	Dasypus_novemcinctus
ENSG00000143621	ILF2	100	100.000	ENSDNOG00000015220	-	99	96.923	Dasypus_novemcinctus
ENSG00000143621	ILF2	100	100.000	ENSDORG00000007966	Ilf2	100	100.000	Dipodomys_ordii
ENSG00000143621	ILF2	100	77.183	ENSDORG00000025413	-	90	82.424	Dipodomys_ordii
ENSG00000143621	ILF2	99	57.103	FBgn0038046	CG5641	86	58.065	Drosophila_melanogaster
ENSG00000143621	ILF2	100	74.783	ENSEBUG00000011722	ilf2	89	63.548	Eptatretus_burgeri
ENSG00000143621	ILF2	100	100.000	ENSEASG00005000879	ILF2	100	99.744	Equus_asinus_asinus
ENSG00000143621	ILF2	100	100.000	ENSECAG00000008567	ILF2	100	99.744	Equus_caballus
ENSG00000143621	ILF2	100	83.846	ENSEEUG00000013100	ILF2	100	83.846	Erinaceus_europaeus
ENSG00000143621	ILF2	100	90.435	ENSELUG00000015989	ILF2	92	92.812	Esox_lucius
ENSG00000143621	ILF2	100	80.870	ENSELUG00000008674	-	89	79.819	Esox_lucius
ENSG00000143621	ILF2	100	100.000	ENSFCAG00000008171	ILF2	100	100.000	Felis_catus
ENSG00000143621	ILF2	100	95.652	ENSFALG00000012046	ILF2	98	95.597	Ficedula_albicollis
ENSG00000143621	ILF2	100	99.716	ENSFDAG00000009216	ILF2	97	98.148	Fukomys_damarensis
ENSG00000143621	ILF2	100	98.261	ENSFDAG00000006422	-	100	96.410	Fukomys_damarensis
ENSG00000143621	ILF2	84	88.660	ENSFHEG00000005038	ILF2	74	88.991	Fundulus_heteroclitus
ENSG00000143621	ILF2	100	89.565	ENSGMOG00000013725	ilf2	86	92.169	Gadus_morhua
ENSG00000143621	ILF2	100	96.591	ENSGALG00000011570	ILF2	87	89.916	Gallus_gallus
ENSG00000143621	ILF2	100	91.304	ENSGACG00000000543	ilf2	87	93.564	Gasterosteus_aculeatus
ENSG00000143621	ILF2	100	98.261	ENSGAGG00000012431	ILF2	100	97.179	Gopherus_agassizii
ENSG00000143621	ILF2	100	100.000	ENSGGOG00000001814	ILF2	100	100.000	Gorilla_gorilla
ENSG00000143621	ILF2	100	91.304	ENSHBUG00000007495	ilf2	86	92.771	Haplochromis_burtoni
ENSG00000143621	ILF2	100	100.000	ENSHGLG00000004134	ILF2	100	100.000	Heterocephalus_glaber_female
ENSG00000143621	ILF2	100	100.000	ENSHGLG00100011410	-	100	96.392	Heterocephalus_glaber_male
ENSG00000143621	ILF2	100	85.217	ENSHGLG00100017501	-	71	82.831	Heterocephalus_glaber_male
ENSG00000143621	ILF2	100	89.565	ENSHCOG00000007106	ilf2	86	90.663	Hippocampus_comes
ENSG00000143621	ILF2	100	91.304	ENSIPUG00000021905	ilf2	86	92.169	Ictalurus_punctatus
ENSG00000143621	ILF2	79	92.308	ENSSTOG00000020511	-	80	75.602	Ictidomys_tridecemlineatus
ENSG00000143621	ILF2	100	99.130	ENSSTOG00000021457	-	98	98.947	Ictidomys_tridecemlineatus
ENSG00000143621	ILF2	100	100.000	ENSSTOG00000000667	ILF2	100	100.000	Ictidomys_tridecemlineatus
ENSG00000143621	ILF2	100	100.000	ENSJJAG00000023269	-	100	100.000	Jaculus_jaculus
ENSG00000143621	ILF2	100	80.000	ENSJJAG00000013500	-	84	81.627	Jaculus_jaculus
ENSG00000143621	ILF2	100	92.174	ENSKMAG00000000823	ilf2	86	92.470	Kryptolebias_marmoratus
ENSG00000143621	ILF2	100	89.565	ENSLBEG00000024204	ilf2	87	91.950	Labrus_bergylta
ENSG00000143621	ILF2	100	87.826	ENSLACG00000007384	ILF2	90	91.875	Latimeria_chalumnae
ENSG00000143621	ILF2	54	94.709	ENSLOCG00000006883	ilf2	87	94.709	Lepisosteus_oculatus
ENSG00000143621	ILF2	100	100.000	ENSLAFG00000028218	ILF2	99	100.000	Loxodonta_africana
ENSG00000143621	ILF2	66	97.863	ENSMFAG00000030239	-	100	97.863	Macaca_fascicularis
ENSG00000143621	ILF2	100	100.000	ENSMFAG00000037304	-	100	100.000	Macaca_fascicularis
ENSG00000143621	ILF2	100	85.422	ENSMMUG00000031442	-	100	85.422	Macaca_mulatta
ENSG00000143621	ILF2	100	100.000	ENSMMUG00000008149	ILF2	100	100.000	Macaca_mulatta
ENSG00000143621	ILF2	65	97.807	ENSMNEG00000012078	-	99	97.807	Macaca_nemestrina
ENSG00000143621	ILF2	99	100.000	ENSMNEG00000011128	-	99	100.000	Macaca_nemestrina
ENSG00000143621	ILF2	73	100.000	ENSMLEG00000037913	ILF2	100	100.000	Mandrillus_leucophaeus
ENSG00000143621	ILF2	100	91.304	ENSMAMG00000020442	ilf2	92	92.812	Mastacembelus_armatus
ENSG00000143621	ILF2	100	91.304	ENSMZEG00005017498	ilf2	86	92.771	Maylandia_zebra
ENSG00000143621	ILF2	100	95.652	ENSMGAG00000005653	-	100	96.447	Meleagris_gallopavo
ENSG00000143621	ILF2	100	100.000	ENSMAUG00000013875	Ilf2	100	100.000	Mesocricetus_auratus
ENSG00000143621	ILF2	98	76.522	ENSMICG00000035317	-	86	83.871	Microcebus_murinus
ENSG00000143621	ILF2	66	100.000	ENSMICG00000013730	-	100	100.000	Microcebus_murinus
ENSG00000143621	ILF2	100	100.000	ENSMOCG00000016112	Ilf2	100	100.000	Microtus_ochrogaster
ENSG00000143621	ILF2	100	80.966	ENSMMOG00000012134	ilf2	91	84.688	Mola_mola
ENSG00000143621	ILF2	100	98.295	ENSMODG00000017376	ILF2	99	98.201	Monodelphis_domestica
ENSG00000143621	ILF2	100	85.795	ENSMALG00000019750	ilf2	85	89.759	Monopterus_albus
ENSG00000143621	ILF2	100	100.000	MGP_CAROLIEiJ_G0025237	Ilf2	100	100.000	Mus_caroli
ENSG00000143621	ILF2	100	100.000	ENSMUSG00000001016	Ilf2	100	100.000	Mus_musculus
ENSG00000143621	ILF2	100	100.000	MGP_PahariEiJ_G0026681	Ilf2	100	100.000	Mus_pahari
ENSG00000143621	ILF2	100	100.000	MGP_SPRETEiJ_G0026180	Ilf2	100	100.000	Mus_spretus
ENSG00000143621	ILF2	100	100.000	ENSMPUG00000008267	ILF2	97	99.483	Mustela_putorius_furo
ENSG00000143621	ILF2	100	99.432	ENSMLUG00000001847	-	99	99.486	Myotis_lucifugus
ENSG00000143621	ILF2	100	97.391	ENSMLUG00000030378	-	100	96.923	Myotis_lucifugus
ENSG00000143621	ILF2	100	99.487	ENSNGAG00000012145	Ilf2	100	99.487	Nannospalax_galili
ENSG00000143621	ILF2	100	91.304	ENSNBRG00000017801	ilf2	86	90.663	Neolamprologus_brichardi
ENSG00000143621	ILF2	100	100.000	ENSNLEG00000010440	ILF2	100	99.485	Nomascus_leucogenys
ENSG00000143621	ILF2	100	98.295	ENSMEUG00000003651	ILF2	100	98.196	Notamacropus_eugenii
ENSG00000143621	ILF2	73	99.612	ENSOPRG00000003728	ILF2	100	99.612	Ochotona_princeps
ENSG00000143621	ILF2	90	98.519	ENSODEG00000011732	-	85	98.519	Octodon_degus
ENSG00000143621	ILF2	100	80.870	ENSODEG00000006935	-	81	77.370	Octodon_degus
ENSG00000143621	ILF2	100	99.130	ENSODEG00000018629	-	100	98.974	Octodon_degus
ENSG00000143621	ILF2	100	91.304	ENSONIG00000010350	ilf2	86	92.771	Oreochromis_niloticus
ENSG00000143621	ILF2	100	100.000	ENSOCUG00000005430	ILF2	96	100.000	Oryctolagus_cuniculus
ENSG00000143621	ILF2	100	90.435	ENSORLG00000010955	ilf2	92	91.562	Oryzias_latipes
ENSG00000143621	ILF2	100	90.435	ENSORLG00020018874	ilf2	86	91.566	Oryzias_latipes_hni
ENSG00000143621	ILF2	100	90.435	ENSORLG00015010674	ilf2	73	91.566	Oryzias_latipes_hsok
ENSG00000143621	ILF2	100	90.435	ENSOMEG00000008691	ilf2	86	91.566	Oryzias_melastigma
ENSG00000143621	ILF2	100	100.000	ENSOARG00000000787	ILF2	100	100.000	Ovis_aries
ENSG00000143621	ILF2	100	100.000	ENSPPAG00000002027	ILF2	100	100.000	Pan_paniscus
ENSG00000143621	ILF2	100	100.000	ENSPPRG00000023707	ILF2	100	100.000	Panthera_pardus
ENSG00000143621	ILF2	100	100.000	ENSPTIG00000017810	ILF2	100	100.000	Panthera_tigris_altaica
ENSG00000143621	ILF2	100	100.000	ENSPTRG00000001358	ILF2	100	100.000	Pan_troglodytes
ENSG00000143621	ILF2	100	100.000	ENSPTRG00000050123	-	100	100.000	Pan_troglodytes
ENSG00000143621	ILF2	100	100.000	ENSPANG00000008736	ILF2	100	100.000	Papio_anubis
ENSG00000143621	ILF2	100	92.174	ENSPKIG00000014302	ilf2	86	93.072	Paramormyrops_kingsleyae
ENSG00000143621	ILF2	100	97.414	ENSPSIG00000004657	ILF2	90	96.884	Pelodiscus_sinensis
ENSG00000143621	ILF2	66	88.462	ENSPMGG00000008441	ilf2	87	94.554	Periophthalmus_magnuspinnatus
ENSG00000143621	ILF2	100	100.000	ENSPEMG00000017802	Ilf2	100	100.000	Peromyscus_maniculatus_bairdii
ENSG00000143621	ILF2	100	98.295	ENSPCIG00000029363	ILF2	100	98.205	Phascolarctos_cinereus
ENSG00000143621	ILF2	100	90.435	ENSPFOG00000000095	ilf2	86	92.470	Poecilia_formosa
ENSG00000143621	ILF2	100	90.435	ENSPLAG00000000522	ilf2	86	92.470	Poecilia_latipinna
ENSG00000143621	ILF2	100	90.435	ENSPMEG00000022858	ilf2	83	91.776	Poecilia_mexicana
ENSG00000143621	ILF2	100	90.435	ENSPREG00000020243	ilf2	92	92.500	Poecilia_reticulata
ENSG00000143621	ILF2	100	100.000	ENSPPYG00000000800	DKFZP469C1132	100	100.000	Pongo_abelii
ENSG00000143621	ILF2	71	100.000	ENSPCAG00000016387	-	99	77.523	Procavia_capensis
ENSG00000143621	ILF2	100	100.000	ENSPCOG00000028569	ILF2	100	100.000	Propithecus_coquereli
ENSG00000143621	ILF2	62	75.909	ENSPCOG00000017222	-	88	75.132	Propithecus_coquereli
ENSG00000143621	ILF2	100	100.000	ENSPVAG00000011077	ILF2	99	99.231	Pteropus_vampyrus
ENSG00000143621	ILF2	100	78.977	ENSPNYG00000019624	ilf2	91	82.188	Pundamilia_nyererei
ENSG00000143621	ILF2	100	90.435	ENSPNAG00000009365	ilf2	86	92.470	Pygocentrus_nattereri
ENSG00000143621	ILF2	100	100.000	ENSRNOG00000014154	Ilf2	100	100.000	Rattus_norvegicus
ENSG00000143621	ILF2	100	100.000	ENSRBIG00000042614	ILF2	100	100.000	Rhinopithecus_bieti
ENSG00000143621	ILF2	100	100.000	ENSRROG00000031990	ILF2	100	92.308	Rhinopithecus_roxellana
ENSG00000143621	ILF2	100	100.000	ENSSBOG00000033031	ILF2	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000143621	ILF2	100	83.807	ENSSBOG00000023173	-	85	83.939	Saimiri_boliviensis_boliviensis
ENSG00000143621	ILF2	100	98.295	ENSSHAG00000010138	ILF2	100	98.205	Sarcophilus_harrisii
ENSG00000143621	ILF2	100	92.174	ENSSFOG00015010137	ilf2	87	93.498	Scleropages_formosus
ENSG00000143621	ILF2	100	90.435	ENSSMAG00000020810	ilf2	86	92.470	Scophthalmus_maximus
ENSG00000143621	ILF2	100	91.304	ENSSDUG00000009850	ilf2	86	92.771	Seriola_dumerili
ENSG00000143621	ILF2	100	91.304	ENSSLDG00000012486	ilf2	92	92.812	Seriola_lalandi_dorsalis
ENSG00000143621	ILF2	64	84.071	ENSSARG00000011984	-	58	84.071	Sorex_araneus
ENSG00000143621	ILF2	57	98.020	ENSSPUG00000003834	ILF2	86	98.020	Sphenodon_punctatus
ENSG00000143621	ILF2	100	92.174	ENSSPAG00000003967	ilf2	86	92.771	Stegastes_partitus
ENSG00000143621	ILF2	100	99.487	ENSSSCG00000028553	ILF2	100	99.487	Sus_scrofa
ENSG00000143621	ILF2	100	90.435	ENSTRUG00000004888	ilf2	86	92.470	Takifugu_rubripes
ENSG00000143621	ILF2	100	81.739	ENSTBEG00000014891	ILF2	90	82.530	Tupaia_belangeri
ENSG00000143621	ILF2	100	100.000	ENSTTRG00000014759	ILF2	99	100.000	Tursiops_truncatus
ENSG00000143621	ILF2	66	100.000	ENSUAMG00000003639	ILF2	100	100.000	Ursus_americanus
ENSG00000143621	ILF2	85	94.898	ENSUAMG00000004033	-	96	94.340	Ursus_americanus
ENSG00000143621	ILF2	100	99.716	ENSUMAG00000020682	ILF2	100	99.716	Ursus_maritimus
ENSG00000143621	ILF2	100	100.000	ENSVPAG00000010262	ILF2	100	100.000	Vicugna_pacos
ENSG00000143621	ILF2	100	100.000	ENSVVUG00000028258	ILF2	100	100.000	Vulpes_vulpes
ENSG00000143621	ILF2	100	89.565	ENSXETG00000014290	ilf2	86	84.084	Xenopus_tropicalis
ENSG00000143621	ILF2	100	90.435	ENSXCOG00000002350	ilf2	86	91.692	Xiphophorus_couchianus
ENSG00000143621	ILF2	100	90.435	ENSXMAG00000003285	ilf2	86	92.470	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003677	DNA binding	7519613.10574923.11804788.	IDA	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003725	double-stranded RNA binding	10574923.	IDA	Function
GO:0005515	protein binding	9442054.10574923.11739746.17289661.21146485.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005576	extracellular region	27068509.	HDA	Component
GO:0005576	extracellular region	-	TAS	Component
GO:0005634	nucleus	21123651.	IDA	Component
GO:0005730	nucleolus	11790298.	IDA	Component
GO:0006351	transcription, DNA-templated	11739746.	IDA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016740	transferase activity	-	IEA	Function
GO:0035580	specific granule lumen	-	TAS	Component
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0045893	positive regulation of transcription, DNA-templated	11739746.	IDA	Process
GO:1904724	tertiary granule lumen	-	TAS	Component
GO:1904813	ficolin-1-rich granule lumen	-	TAS	Component
GO:1990904	ribonucleoprotein complex	17289661.	IDA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

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Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.