EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
18262048	Low molecular weight protein tyrosine phosphatase genetic polymorphism and susceptibility to cancer development.	Cancer Genet Cytogenet	2008 Feb	Alho I	doi: 10.1016/j.cancergencyto.2007.11.004.
27127127	Low Molecular Weight Protein Tyrosine Phosphatase Slow Isoform Knockdown in MDA-MB-435 Cells Decreases RAW 264.7 Osteoclastic Differentiation.	Anticancer Res	2016 May	Alho I	-
23645747	Characterization of low molecular weight protein tyrosine phosphatase isoforms in human breast cancer epithelial cell lines.	Anticancer Res	2013 May	Alho I	-
16036221	Up-regulated expression of low molecular weight protein tyrosine phosphatases in different human cancers.	Biochem Biophys Res Commun	2005 Sep 2	Malentacchi F	-
18786445	ACP1 genetic polymorphism and colon cancer.	Cancer Genet Cytogenet	2008 Oct	Spina C	doi: 10.1016/j.cancergencyto.2008.06.006.
26159288	Low-Molecular-Weight Protein Tyrosine Phosphatase Predicts Prostate Cancer Outcome by Increasing the Metastatic Potential.	Eur Urol	2016 Apr	Ruela-de-Sousa RR	doi: 10.1016/j.eururo.2015.06.040
22692348	Acid phosphatase locus 1 genetic polymorphism and cancer grading.	Am J Med Sci	2012 Jul	Gloria-Bottini F	doi: 10.1097/MAJ.0b013e31823e5cfa.
29187443	Total Knockdown of LMW-PTP in MDA-MB-231 Cells Reduces Osteoclastogenesis.	Anticancer Res	2017 Dec	Sapinho G	-
30326476	Prediction of Time to Castration-Resistant Prostate Cancer Using Low-Molecular-Weight Protein Tyrosine Phosphatase Expression for Men with Metastatic Hormone-Nave Prostate Cancer.	Urol Int	2019	Miyoshi Y	doi: 10.1159/000493324

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr2	272114	Silent	novel	K65K	0.56
BLCA	chr2	264987	Missense_Mutation	NA	S8Y	0.05
BLCA	chr2	275176	Silent	NA	L90L	0.11
BLCA	chr2	272238	Intron	novel		0.13
BRCA	chr2	264982	Silent	novel	T6T	0.16
CESC	chr2	272070	Missense_Mutation	NA	E51Q	0.29
COAD	chr2	271878	Missense_Mutation	rs769115575	R19Q	0.29
COAD	chr2	277042	Missense_Mutation	NA	S119N	0.35
COAD	chr2	277491	3'UTR	novel		0.44
COAD	chr2	272415	Intron	NA		0.36
COAD	chr2	275179	Missense_Mutation	novel	C91R	0.18
COAD	chr2	272081	Frame_Shift_Del	NA	*P56Lfs9**	0.39
COAD	chr2	272080	Frame_Shift_Ins	NA	D57*	0.34
COAD	chr2	277274	Nonsense_Mutation	NA	C149*	0.21
COAD	chr2	272232	Intron	rs763912438		0.25
ESCA	chr2	271940	Splice_Site	novel	X40_splice	0.12
GBM	chr2	264919	5'UTR	novel		0.21
GBM	chr2	272312	Intron	novel		0.08
HNSC	chr2	271881	Missense_Mutation	novel	S20L	0.08
HNSC	chr2	264914	5'UTR	novel		0.34
KIRC	chr2	264937	5'UTR	novel		0.22
KIRC	chr2	277362	3'UTR	novel		0.07
KIRC	chr2	277363	3'UTR	novel		0.03
LAML	chr2	264945	5'UTR	novel		0.4
LGG	chr2	277249	Missense_Mutation	rs375641056	T141M	0.4
LIHC	chr2	277266	Missense_Mutation	NA	V147I	0.09
LIHC	chr2	264960	5'UTR	novel		0.52
LIHC	chr2	277013	Silent	NA	T109T	0.15
LIHC	chr2	277439	3'UTR	novel		0.45
LUAD	chr2	275160	Silent	novel	A84A	0.15
LUAD	chr2	272282	Intron	NA		0.34
LUAD	chr2	277071	Missense_Mutation	novel	E129Q	0.26
LUAD	chr2	264964	5'UTR	novel		0.08
LUAD	chr2	272088	Missense_Mutation	novel	D57Y	0.26
LUAD	chr2	277226	Splice_Site	NA	X134_splice	0.25
LUSC	chr2	264937	5'UTR	novel		0.19
LUSC	chr2	264919	5'UTR	novel		0.06
LUSC	chr2	272235	Intron	NA		0.7
LUSC	chr2	272236	Intron	NA		0.7
LUSC	chr2	277020	Missense_Mutation	NA	A112P	0.35
LUSC	chr2	277335	3'UTR	novel		0.13
LUSC	chr2	277367	3'UTR	novel		0.14
LUSC	chr2	264894	5'UTR	novel		0.19
OV	chr2	277297	Missense_Mutation	novel	A157D	0.05
OV	chr2	272227	Intron	NA		0.19
OV	chr2	277347	3'UTR	novel		0.11
OV	chr2	264932	5'UTR	novel		0.16
OV	chr2	272228	Intron	rs775443798		0.11
OV	chr2	277055	Silent	novel	Q123Q	0.04
PAAD	chr2	277325	3'UTR	rs529906639		0.07
PRAD	chr2	271876	Missense_Mutation	novel	C18W	0.5
PRAD	chr2	264886	5'UTR	novel		0.29
PRAD	chr2	264886	5'UTR	novel		0.43
PRAD	chr2	272206	Intron	rs781441469		0.56
SKCM	chr2	277313	3'UTR	rs547572404		0.28
SKCM	chr2	272235	Intron	NA		0.2
SKCM	chr2	272289	Intron	novel		0.32
SKCM	chr2	277050	Missense_Mutation	NA	P122S	0.34
SKCM	chr2	277292	Silent	rs150164591	E155E	0.33
SKCM	chr2	272128	Missense_Mutation	NA	P70L	0.25
SKCM	chr2	272154	Splice_Region	novel		0.35
SKCM	chr2	271865	Splice_Site	NA	X15_splice	0.49
STAD	chr2	272122	Missense_Mutation	novel	G68D	0.2
STAD	chr2	277054	Frame_Shift_Del	novel	*K124Nfs61**	0.17
STAD	chr2	277054	Frame_Shift_Del	novel	*K124Nfs61**	0.2
STAD	chr2	277054	Frame_Shift_Del	novel	*K124Nfs61**	0.33
STAD	chr2	272130	Missense_Mutation	novel	M71V	0.1
STAD	chr2	271876	Silent	NA	C18C	0.19
STAD	chr2	272055	Missense_Mutation	NA	A46T	0.34
STAD	chr2	277054	Frame_Shift_Del	novel	*K124Nfs61**	0.49
UCEC	chr2	277002	Nonsense_Mutation	rs553260669	Q106*	0.4
UCEC	chr2	277495	3'UTR	NA		0.38
UCEC	chr2	272206	Intron	rs781441469		0.2
UCEC	chr2	272215	Intron	novel		0.28
UCEC	chr2	272362	Intron	rs369085813		0.11
UCEC	chr2	277361	3'UTR	novel		0.14
UCEC	chr2	272236	Intron	NA		0.22
UCEC	chr2	271932	Missense_Mutation	novel	S37L	0.35
UCEC	chr2	272197	Intron	novel		0.37
UCEC	chr2	272347	Intron	novel		0.34
UCEC	chr2	272492	Intron	novel		0.18
UCEC	chr2	272493	Intron	novel		0.2
UCEC	chr2	277503	3'UTR	novel		0.21
UCEC	chr2	272202	Intron	NA		0.36
UCEC	chr2	272325	Intron	novel		0.07

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	AMP	0.3162	0.033813
CESC	AMP	0.2339	0.099937
KIRP	DEL	0.0278	0.08832
LUSC	DEL	0.0739	0.20634
OV	DEL	0.1641	0.087942
PAAD	DEL	0.0924	0.2014
SARC	DEL	0.3268	3.2554e-05
TGCT	AMP	0.28	0.0050216
UCEC	DEL	0.0371	0.18809

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0028	Kaplan-Meier Survival Analysis
KIRC	0.00048	Kaplan-Meier Survival Analysis
ACC	0.00075	Kaplan-Meier Survival Analysis
LUSC	0.004	Kaplan-Meier Survival Analysis
PCPG	0.025	Kaplan-Meier Survival Analysis
UCEC	0.0098	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
LGG	0.0012	Kaplan-Meier Survival Analysis
LUAD	0.018	Kaplan-Meier Survival Analysis
OV	0.044	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000143727 (Gene tree)
Gene ID: 52
Gene Symbol: ACP1
Alias: HAAP|LMW-PTP|LMWPTP
Full Name: acid phosphatase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 14,144 bases
Position: chr2:264,140-278,283
Accession: 122
RBP type: non-canonical RBP
Summary: The product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate. This gene is genetically polymorphic, and three common alleles segregating at the corresponding locus give rise to six phenotypes. Each allele appears to encode at least two electrophoretically different isozymes, Bf and Bs, which are produced in allele-specific ratios. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000442386	ACP1-208	546	-	ENSP00000389681	46 (aa)	-	F2Z2R9
ENST00000407983	ACP1-205	703	-	ENSP00000385404	112 (aa)	-	P24666
ENST00000413140	ACP1-206	689	-	ENSP00000410331	80 (aa)	-	G5E9R5
ENST00000453390	ACP1-209	577	-	ENSP00000411121	70 (aa)	-	F2Z2Q9
ENST00000484125	ACP1-212	559	-	-	- (aa)	-	-
ENST00000480874	ACP1-211	732	-	-	- (aa)	-	-
ENST00000405233	ACP1-203	1149	-	ENSP00000384307	70 (aa)	-	F2Z2Q9
ENST00000272067	ACP1-202	1552	-	ENSP00000272067	158 (aa)	-	P24666
ENST00000272065	ACP1-201	1549	-	ENSP00000272065	158 (aa)	-	P24666
ENST00000463831	ACP1-210	1015	-	-	- (aa)	-	-
ENST00000439645	ACP1-207	605	-	ENSP00000408596	85 (aa)	-	D3YTI2
ENST00000484464	ACP1-213	573	-	-	- (aa)	-	-
ENST00000405364	ACP1-204	414	-	ENSP00000384184	46 (aa)	-	F2Z2R9

Gene Model

Click here to download ENSG00000143727's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00730	Thiamine metabolism	KEGG
hsa00740	Riboflavin metabolism	KEGG
hsa01100	Metabolic pathways	KEGG
hsa04520	Adherens junction	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000143727	rs79716074	2	277003	G	Blood protein levels	29875488	[1.12-1.2] unit increase	1.16	EFO_0007937
ENSG00000143727	rs11553746	2	272203	T	Blood protein levels	28240269	[1.19-1.29] unit increase	1.237	EFO_0008213
ENSG00000143727	rs58461606	2	267367	G	Blood protein levels	30072576	[1.1-1.17] unit decrease	1.134	EFO_0007937
ENSG00000143727	rs59937473	2	271797	A	Smoking initiation (ever regular vs never regular) (MTAG)	30643251	[0.0037-0.0081] unit decrease	0.00590285	EFO_0006527
ENSG00000143727	rs114976176	2	264621	C	Smoking initiation (ever regular vs never regular)	30643251	[0.01-0.021] unit decrease	0.015513658	EFO_0006527

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000143727's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003993	acid phosphatase activity	-	IEA	Function
GO:0004725	protein tyrosine phosphatase activity	21873635.	IBA	Function
GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	-	IEA	Function
GO:0005515	protein binding	9499402.15846844.25556234.	IPI	Function
GO:0005737	cytoplasm	10940933.	IDA	Component
GO:0009898	cytoplasmic side of plasma membrane	10940933.	IDA	Component
GO:0035335	peptidyl-tyrosine dephosphorylation	-	IEA	Process
GO:0070062	extracellular exosome	19056867.23533145.	HDA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.