EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
22226966The AAA-ATPase NVL2 is a telomerase component essential for holoenzyme assembly.Biochem Biophys Res Commun2012 Jan 20Her Jdoi: 10.1016/j.bbrc.2011.12.101

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1224305150Missense_MutationNAS211C0.32
BLCAchr1224233207Missense_MutationNAE817Q0.22
BLCAchr1224289568SilentNAQ497Q0.39
BLCAchr1224300608Missense_MutationnovelS339F0.45
BLCAchr1224308174Frame_Shift_DelnovelE145Kfs*90.14
BLCAchr1224308038SilentnovelL190L0.71
BLCAchr1224287810Missense_MutationnovelE587Q0.12
BLCAchr1224300614Missense_MutationnovelG337V0.32
BLCAchr1224287910SilentnovelL553L0.28
BLCAchr1224304750Missense_MutationNAD271N0.18
BRCAchr1224304751SilentNAN270N0.16
BRCAchr1224330126Translation_Start_SiteNAM1?0.15
BRCAchr1224300656Missense_MutationnovelD323A0.42
BRCAchr1224233255Missense_MutationNAS801A0.15
BRCAchr1224275408Silentrs149269387K671K0.14
BRCAchr1224289516Missense_Mutationrs751450518R515G0.04
BRCAchr1224289693Missense_Mutationrs755757900A456T0.14
BRCAchr1224227670Missense_MutationnovelD843N0.15
BRCAchr1224275343Missense_Mutationrs376797399R693Q0.13
CESCchr1224294358Nonsense_Mutationrs773133873R412*0.1
CESCchr1224308182Missense_MutationnovelE142Q0.07
CESCchr1224236521Missense_Mutationrs761421541R784H0.23
CESCchr1224289576Missense_MutationNAE495K0.36
CHOLchr1224289638Missense_MutationnovelL474P0.25
COADchr1224231231Missense_MutationnovelK841Q0.32
COADchr1224227632SilentNAS855S0.35
COADchr1224287856SilentNAG571G0.34
COADchr1224305153Missense_MutationNAS210Y0.36
COADchr1224275387SilentnovelI678I0.12
COADchr1224311847Missense_MutationnovelS99R0.2
COADchr1224300649SilentnovelP325P0.26
COADchr1224330082Nonsense_Mutationrs749185581R16*0.23
COADchr12243301505'UTRnovel0.38
COADchr1224308132SilentnovelG158G0.04
COADchr1224308069SilentNAP179P0.32
COADchr1224236552Missense_MutationNAV774I0.13
COADchr1224236521Missense_Mutationrs761421541R784H0.15
COADchr1224303801Silentrs760806939G294G0.19
COADchr1224303830Missense_Mutationrs772843150R285C0.24
COADchr1224287876Missense_MutationNAP565S0.61
ESCAchr1224308068Missense_MutationnovelS180C0.25
ESCAchr1224305092Missense_MutationnovelR230S0.48
ESCAchr1224326457Frame_Shift_InsnovelT22Ifs*150.16
ESCAchr1224286107SilentnovelQ606Q0.04
GBMchr1224294380SilentnovelV404V0.06
GBMchr1224231243Missense_MutationnovelS837P0.3
GBMchr1224326403Missense_MutationNAQ40R0.4
GBMchr1224257082Intronnovel0.45
GBMchr1224330083SilentnovelQ15Q0.26
GBMchr1224257036Intronrs7786920740.78
HNSCchr1224317906Frame_Shift_DelnovelR52Kfs*40.17
HNSCchr1224304795Missense_MutationnovelE256Q0.06
HNSCchr1224275392Missense_MutationnovelV677L0.34
HNSCchr1224275397Missense_MutationnovelP675R0.35
KIRCchr1224257036Intronrs7786920740.42
KIRCchr1224317887Missense_Mutationrs754254646V59I0.2
KIRCchr1224303840SilentNAL281L0.31
KIRPchr1224257021Intronnovel0.47
KIRPchr1224236561Missense_MutationnovelD771Y0.31
LGGchr1224289667SilentNAH464H0.36
LIHCchr1224294348Missense_MutationNAS415L0.07
LIHCchr1224227635SilentnovelL854L0.28
LIHCchr1224287901Missense_MutationNAF556L0.24
LUADchr12242275963'UTRnovel0.24
LUADchr1224281173Missense_MutationnovelE638K0.1
LUADchr1224281151Missense_MutationnovelS645F0.25
LUADchr1224317743Missense_MutationnovelE79K0.15
LUADchr1224289540Missense_MutationNAP507S0.06
LUADchr1224326400Missense_MutationnovelR41K0.3
LUADchr1224303729Missense_MutationnovelI318M0.51
LUADchr1224236539Missense_MutationNAA778V0.16
LUADchr1224300573Nonsense_MutationnovelE351*0.41
LUADchr1224287913SilentnovelE552E0.23
LUSCchr1224294348Missense_MutationNAS415L0.24
LUSCchr12242274733'UTRnovel0.75
LUSCchr1224268101SilentnovelL705L0.35
LUSCchr1224286074SilentNAG617G0.24
LUSCchr1224287884Nonsense_MutationNAS562*0.18
LUSCchr1224275410Missense_MutationnovelK671E0.51
LUSCchr1224326410Missense_MutationNAD38H0.11
LUSCchr1224287979SilentNAR530R0.57
LUSCchr1224233207Missense_MutationNAE817K0.1
LUSCchr1224275408Missense_MutationnovelK671N0.34
LUSCchr1224250288Missense_MutationnovelG738D0.34
LUSCchr12242275203'UTRnovel0.26
LUSCchr1224308091Missense_Mutationrs537722770G172E0.04
LUSCchr1224305102Missense_MutationnovelG227V0.48
LUSCchr1224303854Missense_MutationnovelV277L0.18
MESOchr1224303787Missense_MutationnovelR299H0.65
OVchr1224268049Missense_MutationnovelA723T0.1
PAADchr1224257026Intronnovel0.37
PRADchr1224294311SilentnovelD427D0.39
READchr1224257096Intronnovel0.04
READchr1224311852Missense_MutationNAT97S0.34
READchr1224308056Missense_MutationnovelD184Y0.46
READchr1224233248Missense_MutationnovelC803Y0.24
SKCMchr1224308016Missense_Mutationrs776316720P197L0.23
SKCMchr1224286068SilentnovelL619L0.45
SKCMchr1224308224Missense_Mutationrs200984793R128W0.51
SKCMchr1224250252Missense_Mutationrs571963590P750L0.28
SKCMchr1224287901SilentNAF556F0.32
SKCMchr1224294370Missense_MutationNAG408R0.13
SKCMchr12242276103'UTRnovel0.45
SKCMchr12242276113'UTRrs1884000540.45
SKCMchr1224286097Missense_MutationnovelL610V0.13
SKCMchr1224287887Missense_MutationNAS561F0.11
SKCMchr1224289555Nonsense_MutationNAE502*0.25
SKCMchr1224294339Missense_MutationnovelP418L0.34
SKCMchr1224294348Missense_MutationNAS415L0.1
SKCMchr1224286068SilentnovelL619L0.13
SKCMchr1224294386SilentNAA402A0.18
SKCMchr1224308124Missense_MutationnovelP161L0.09
SKCMchr1224287808SilentNAE587E0.48
SKCMchr1224289667SilentNAH464H0.35
SKCMchr1224231295Splice_RegionNAG819G0.16
STADchr1224303727Missense_MutationNAA319V0.08
STADchr12242275703'UTRnovel0.24
STADchr1224257036Intronrs7786920740.45
STADchr1224268118Nonsense_Mutationrs367715317R700*0.27
STADchr1224326414Silentrs758806110A36A0.37
STADchr1224308097Missense_MutationNAE170G0.03
STADchr1224236506Missense_Mutationrs768455674T789M0.19
STADchr1224300607Silentrs143457273S339S0.51
STADchr1224326414Silentrs758806110A36A0.24
STADchr1224257077Intronnovel0.26
UCECchr1224250230SilentnovelI757I0.05
UCECchr1224294314SilentNAF426F0.25
UCECchr1224308224Missense_Mutationrs200984793R128W0.13
UCECchr1224257084IntronNA0.34
UCECchr12242275323'UTRnovel0.25
UCECchr1224250264Frame_Shift_Delrs765634292F745Wfs*130.48
UCECchr12242276223'UTRnovel0.29
UCECchr1224231226Frame_Shift_InsNAD843Gfs*60.38
UCECchr12242275323'UTRnovel0.48
UCECchr1224317752Missense_MutationNAT76A0.19
UCECchr1224250298Missense_MutationNAL735M0.2
UCECchr1224289576Missense_MutationNAE495K0.22
UCECchr1224250254Silentrs769904366P749P0.51
UCECchr1224294299SilentnovelC431C0.27
UCECchr1224231290Missense_MutationnovelL821R0.14
UCECchr1224305110SilentnovelK224K0.17
UCECchr1224257112Intronnovel0.07
UCECchr1224287924SilentnovelL549L0.23
UCECchr1224275408Missense_MutationnovelK671N0.37
UCECchr1224317907Missense_MutationnovelR52I0.16
UCECchr1224326448Missense_MutationnovelK25T0.36
UCECchr1224289628SilentnovelL477L0.22
UCECchr1224250254Silentrs769904366P749P0.24
UCECchr1224250253Missense_MutationnovelP750S0.35
UCECchr1224326436Missense_MutationNAY29C0.34
UCECchr1224250291Missense_MutationNAP737L0.34
UCECchr1224296547Frame_Shift_DelnovelD379Ifs*70.35
UCECchr12242275313'UTRnovel0.63
UCECchr1224296586Missense_MutationnovelE365D0.13
UCECchr1224257036Intronrs7786920740.39
UCECchr1224275436Missense_MutationNAA662D0.21
UCECchr1224317759Missense_Mutationrs148207074K73N0.36
UCECchr1224233254Missense_MutationNAS801Y0.41
UCECchr1224294361Missense_MutationNAN411D0.35
UCECchr1224257036Intronrs7786920740.69
UCECchr1224317779Missense_MutationnovelS67G0.27
UCECchr1224275431Nonsense_Mutationrs760493438R664*0.34
UCECchr1224300653Missense_MutationNAL324P0.19
UCECchr1224289623Missense_Mutationrs769948002R479Q0.24
UCECchr1224308155Missense_MutationnovelP151S0.41
UCECchr1224294332SilentNAL420L0.24
UCECchr1224257030Intronrs7704767420.28
UCECchr1224326414Silentrs758806110A36A0.43
UCECchr1224250264Frame_Shift_Delrs765634292F745Wfs*130.3
UCECchr1224296561Nonsense_MutationnovelE374*0.09
UCECchr1224308045Missense_MutationNAF187L0.13
UCECchr1224268073Missense_MutationNAR715C0.33
UCECchr1224287877SilentnovelQ564Q0.23
UCECchr1224257131IntronNA0.16
UCECchr1224300664Splice_SitenovelX321_splice0.32
UCECchr1224311821Missense_MutationnovelM107I0.19
UCECchr1224308152Missense_Mutationrs748891622R152W0.18
UCECchr1224308046Frame_Shift_DelnovelF187Sfs*150.15
UCECchr1224317917Nonsense_Mutationrs748581297R49*0.42
UCECchr1224294309Missense_Mutationrs753321668R428Q0.08
UCECchr1224307997Missense_MutationnovelE203D0.16
UCECchr1224275384Missense_MutationNAF679L0.24
UCECchr12242275723'UTRnovel0.14
UCECchr1224257125Intronnovel0.18
UCECchr1224317907Missense_MutationnovelR52I0.37
UCECchr12242275333'UTRnovel0.31
UCECchr1224281164SilentNAL641L0.16
UCECchr1224296578Missense_MutationnovelA368V0.05
UCECchr12242275703'UTRnovel0.36
UCSchr1224294313Missense_MutationnovelD427N0.28

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BLCADEL0.07840.033566
DLBCDEL0.1250.0017831
GBMDEL0.07110.00056261
KIRCDEL0.06630.018371
LGGDEL0.03510.11599
PCPGDEL0.08020.12617
READAMP0.26060.14328
SARCDEL0.29572.6086e-08
TGCTDEL0.03330.16985
THYMAMP0.17890.24554
UCECAMP0.37482.3921e-06

Survival Analysis
CancerP-value Q-value
KIRC0.00013

Kaplan-Meier Survival Analysis

MESO0.039

Kaplan-Meier Survival Analysis

ESCA0.028

Kaplan-Meier Survival Analysis

KIRP0.00012

Kaplan-Meier Survival Analysis

COAD0.018

Kaplan-Meier Survival Analysis

KICH0.0088

Kaplan-Meier Survival Analysis

GBM0.027

Kaplan-Meier Survival Analysis

LIHC0.0021

Kaplan-Meier Survival Analysis

LGG0.032

Kaplan-Meier Survival Analysis

LUAD0.022

Kaplan-Meier Survival Analysis

OV0.038

Kaplan-Meier Survival Analysis

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000143748 (Gene tree)
Gene ID
4931
Gene Symbol
NVL
Alias
NVL2
Full Name
nuclear VCP like
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
103,054 bases
Position
chr1:224,227,334-224,330,387
Accession
8070
RBP type
non-canonical RBP
Summary
This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. Two encoded proteins, described as major and minor isoforms, have been localized to distinct regions of the nucleus. The largest encoded protein (major isoform) has been localized to the nucleolus and shown to participate in ribosome biosynthesis (PMID: 15469983, 16782053), while the minor isoform has been localized to the nucleoplasmin. [provided by RefSeq, Aug 2011]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
21474449Structure and function of the N-terminal nucleolin binding domain of nuclear valosin-containing protein-like 2 (NVL2) harboring a nucleolar localization signal.J Biol Chem2011 Jun 17Fujiwara Ydoi: 10.1074/jbc.M110.174680
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000468673NVL-210921--- (aa)--
ENST00000340871NVL-2022431XM_011544200ENSP00000341362667 (aa)XP_011542502O15381
ENST00000493060NVL-222639--- (aa)--
ENST00000498767NVL-224581--- (aa)--
ENST00000468088NVL-209248--- (aa)--
ENST00000483094NVL-217652--- (aa)--
ENST00000467882NVL-2081310-ENSP00000419930296 (aa)-E9PH71
ENST00000482491NVL-2163003XM_011544199ENSP00000417213667 (aa)XP_011542501O15381
ENST00000489194NVL-220692--- (aa)--
ENST00000487758NVL-218640--- (aa)--
ENST00000488718NVL-219564-ENSP00000419828184 (aa)-E7EWK7
ENST00000462893NVL-207624--- (aa)--
ENST00000436927NVL-204766-ENSP00000394884171 (aa)-C9JP83
ENST00000391875NVL-2032832XM_011544198ENSP00000375747750 (aa)XP_011542500O15381
ENST00000496393NVL-223588--- (aa)--
ENST00000281701NVL-2013123XM_011544196ENSP00000281701856 (aa)XP_011542498O15381
ENST00000469075NVL-2112566-ENSP00000417826765 (aa)-O15381
ENST00000492281NVL-221553-ENSP00000418380180 (aa)-C9J6P7
ENST00000470989NVL-214567-ENSP0000041958653 (aa)-F8WF01
ENST00000461546NVL-206577-ENSP00000418085175 (aa)-E9PGD8
ENST00000461466NVL-205693--- (aa)--
ENST00000481213NVL-215591-ENSP0000047923548 (aa)-A0A087WV72
ENST00000470903NVL-213548--- (aa)--
ENST00000469968NVL-2122510-ENSP00000419420659 (aa)-O15381
Gene Model
Click here to download ENSG00000143748's gene model file
Pathways
Pathway IDPathway NameSource
hsa03008Ribosome biogenesis in eukaryotesKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000143748Heart Failure9.1038000E-004-
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000143748's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000143748NVL10089.339ENSMUSG00000026516Nvl10087.850Mus_musculus
ENSG00000143748NVL9347.699YLL034C7449.760Saccharomyces_cerevisiae
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000176nuclear exosome (RNase complex)26166824.IDAComponent
GO:0003723RNA binding22658674.HDAFunction
GO:0005515protein binding15469983.16782053.22226966.26166824.28416111.IPIFunction
GO:0005524ATP binding22226966.IMPFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus16782053.IDAComponent
GO:0005654nucleoplasm15469983.IDAComponent
GO:0005697telomerase holoenzyme complex22226966.IDAComponent
GO:0005730nucleolus15469983.22226966.IDAComponent
GO:0005730nucleolus26456651.IDAComponent
GO:0006364rRNA processing29107693.IDAProcess
GO:0016020membrane19946888.HDAComponent
GO:0016887ATPase activity21873635.IBAFunction
GO:0032092positive regulation of protein binding29107693.IDAProcess
GO:0042254ribosome biogenesis21873635.IBAProcess
GO:0042254ribosome biogenesis15469983.16782053.IMPProcess
GO:0042273ribosomal large subunit biogenesis26166824.IDAProcess
GO:0042273ribosomal large subunit biogenesis26456651.IMPProcess
GO:0051973positive regulation of telomerase activity21873635.IBAProcess
GO:0051973positive regulation of telomerase activity22226966.IMPProcess
GO:1904749regulation of protein localization to nucleolus29107693.IDAProcess
GO:1990275preribosome binding21873635.IBAFunction
GO:1990275preribosome binding16782053.IDAFunction
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