EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26655997	Restoration of miR-127-3p and miR-376a-3p counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells by targeting COA1, GLE1 and PDIA6.	Cancer Lett	2016 Feb 1	Fellenberg J	doi: 10.1016/j.canlet.2015.10.039
28866093	MiR-127 and miR-376a act as tumor suppressors by invivo targeting of COA1 and PDIA6 in giant cell tumor of bone.	Cancer Lett	2017 Nov 28	Herr I	doi: 10.1016/j.canlet.2017.08.029
27760590	The Inhibitory Effect of PDIA6 Downregulation on Bladder Cancer Cell Proliferation and Invasion.	Oncol Res	2017 Apr 14	Cheng HP	doi: 10.3727/096504016X14761811155298
24464223	The protein disulfide isomerases PDIA4 and PDIA6 mediate resistance to cisplatin-induced cell death in lung adenocarcinoma.	Cell Death Differ	2014 May	Tufo G	doi: 10.1038/cdd.2013.193
26125904	PDIA3 and PDIA6 gene expression as an aggressiveness marker in primary ductal breast cancer.	Genet Mol Res	2015 Jun 26	Ramos FS	doi: 10.4238/2015.June.26.4.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr2	10790823	Missense_Mutation	novel	E199Q	0.17
BLCA	chr2	10791918	Missense_Mutation	novel	S154N	0.19
BLCA	chr2	10789794	Silent	novel	A265A	0.3
BLCA	chr2	10788953	Missense_Mutation	novel	T290K	0.2
BLCA	chr2	10812690	Missense_Mutation	NA	L3F	0.26
BLCA	chr2	10784966	Missense_Mutation	novel	E408Q	0.62
BRCA	chr2	10797733	Silent	novel	T62T	0.1
CESC	chr2	10819313	Missense_Mutation	novel	P46A	0.18
CESC	chr2	10837536	Missense_Mutation	novel	R24C	0.39
CESC	chr2	10837728	5'UTR	novel		0.47
CESC	chr2	10802617	Silent	novel	L15L	0.31
CESC	chr2	10791822	Missense_Mutation	rs373388851	Y186C	0.39
COAD	chr2	10789851	Silent	rs779374855	G246G	0.15
COAD	chr2	10797125	Missense_Mutation	NA	I101T	0.28
COAD	chr2	10802575	Missense_Mutation	novel	E29K	0.08
COAD	chr2	10793164	Missense_Mutation	novel	S129G	0.27
COAD	chr2	10793120	Silent	rs746420885	S143S	0.27
COAD	chr2	10797101	Frame_Shift_Del	novel	*N109Tfs16**	0.33
COAD	chr2	10787345	Missense_Mutation	rs138012463	R365C	0.07
COAD	chr2	10790786	Missense_Mutation	NA	T211M	0.31
COAD	chr2	10791828	Missense_Mutation	novel	E184A	0.09
COAD	chr2	10790812	Silent	rs769286711	A202A	0.44
COAD	chr2	10788901	Silent	rs143264920	D307D	0.43
COAD	chr2	10788738	Frame_Shift_Del	novel	*Y316Ffs2**	0.07
COAD	chr2	10784309	Silent	novel	D424D	0.3
COAD	chr2	10789773	Silent	rs138784297	N272N	0.47
ESCA	chr2	10790785	Silent	novel	T211T	0.25
GBM	chr2	10789789	Missense_Mutation	novel	D267G	0.06
GBM	chr2	10789830	Silent	rs147509333	D253D	0.28
HNSC	chr2	10802509	Missense_Mutation	novel	Y51N	0.16
HNSC	chr2	10802510	Silent	rs749186475	F50F	0.17
HNSC	chr2	10791829	Missense_Mutation	novel	E184Q	0.15
HNSC	chr2	10812700	5'UTR	novel		0.13
KIRC	chr2	10793112	Frame_Shift_Del	novel	*Y146Qfs9**	0.14
KIRC	chr2	10784300	Silent	NA	L427L	0.33
KIRC	chr2	10791863	Missense_Mutation	NA	K172N	0.27
KIRC	chr2	10787422	Missense_Mutation	novel	A339D	0.4
KIRP	chr2	10787403	Silent	NA	L345L	0.11
LGG	chr2	10789851	Silent	rs779374855	G246G	0.25
LGG	chr2	10788713	Missense_Mutation	NA	K328E	0.19
LIHC	chr2	10797121	Missense_Mutation	novel	K102N	0.29
LUAD	chr2	10787408	Missense_Mutation	novel	E344Q	0.07
LUAD	chr2	10789816	Missense_Mutation	novel	R258K	0.13
LUAD	chr2	10793158	Silent	NA	L131L	0.3
LUAD	chr2	10791877	Missense_Mutation	rs528723508	D168N	0.16
LUAD	chr2	10787345	Missense_Mutation	rs138012463	R365C	0.37
LUSC	chr2	10797133	Missense_Mutation	novel	F98L	0.14
LUSC	chr2	10788696	Splice_Site	novel	X333_splice	0.43
LUSC	chr2	10790785	Silent	rs145487229	T211T	0.11
LUSC	chr2	10793121	Frame_Shift_Del	novel	*S143Tfs20**	0.33
OV	chr2	10784972	Missense_Mutation	NA	I406V	0.48
OV	chr2	10797097	Silent	novel	R110R	0.08
PAAD	chr2	10791856	Missense_Mutation	NA	L175M	0.3
PRAD	chr2	10812717	5'UTR	novel		0.5
PRAD	chr2	10793152	Missense_Mutation	NA	Q133E	0.19
PRAD	chr2	10788922	Silent	NA	A300A	0.4
READ	chr2	10784970	Silent	NA	I406I	0.39
READ	chr2	10789862	Missense_Mutation	novel	F243V	0.11
READ	chr2	10788755	Missense_Mutation	novel	N314H	0.07
SKCM	chr2	10784977	Missense_Mutation	novel	P404L	0.36
SKCM	chr2	10784978	Missense_Mutation	novel	P404S	0.36
SKCM	chr2	10787285	Missense_Mutation	NA	L385F	0.25
SKCM	chr2	10797163	Silent	NA	S88S	0.11
SKCM	chr2	10787313	Silent	NA	S375S	0.39
SKCM	chr2	10789806	Silent	NA	I261I	0.14
SKCM	chr2	10787369	Missense_Mutation	NA	P357S	0.09
STAD	chr2	10789851	Silent	rs779374855	G246G	0.19
STAD	chr2	10789843	Missense_Mutation	NA	P249H	0.12
STAD	chr2	10789851	Silent	rs779374855	G246G	0.46
STAD	chr2	10790769	Missense_Mutation	NA	L217V	0.21
STAD	chr2	10787396	Missense_Mutation	rs200773446	A348T	0.21
STAD	chr2	10788711	Silent	novel	K328K	0.57
UCEC	chr2	10802510	Missense_Mutation	rs749186475	F50L	0.23
UCEC	chr2	10790800	Silent	novel	E206E	0.26
UCEC	chr2	10789790	Missense_Mutation	novel	D267Y	0.08
UCEC	chr2	10788923	Missense_Mutation	novel	A300D	0.47
UCEC	chr2	10788973	Silent	rs189599067	N283N	0.41
UCEC	chr2	10791824	Missense_Mutation	novel	F185L	0.36
UCEC	chr2	10788746	Missense_Mutation	novel	L317M	0.09
UCEC	chr2	10802546	Missense_Mutation	NA	E38D	0.45
UCEC	chr2	10787366	Missense_Mutation	rs187929195	A358T	0.25
UCEC	chr2	10787316	Silent	NA	G374G	0.17
UCEC	chr2	10802510	Missense_Mutation	rs749186475	F50L	0.09
UCEC	chr2	10837747	5'UTR	novel		0.5
UCEC	chr2	10787351	Missense_Mutation	novel	N363D	0.32
UCEC	chr2	10789843	Missense_Mutation	NA	P249H	0.29
UCEC	chr2	10791852	Missense_Mutation	novel	D176V	0.52
UCEC	chr2	10787435	Silent	NA	L335L	0.25
UCEC	chr2	10791878	Missense_Mutation	NA	D167E	0.23
UCEC	chr2	10802520	Missense_Mutation	novel	L47R	0.49
UCEC	chr2	10789806	Silent	NA	I261I	0.47
UCEC	chr2	10837526	Missense_Mutation	novel	R27H	0.46
UCEC	chr2	10789773	Silent	rs138784297	N272N	0.52
UCEC	chr2	10819342	Missense_Mutation	novel	S36Y	0.4
UCEC	chr2	10787351	Missense_Mutation	novel	N363D	0.35
UCEC	chr2	10819312	Missense_Mutation	novel	P46L	0.38
UCEC	chr2	10820866	5'UTR	novel		0.19
UCEC	chr2	10789773	Silent	rs138784297	N272N	0.26
UCEC	chr2	10788751	Missense_Mutation	NA	S315Y	0.27
UCEC	chr2	10787285	Missense_Mutation	novel	L385I	0.23
UCEC	chr2	10789773	Silent	rs138784297	N272N	0.29
UCEC	chr2	10790809	Silent	novel	A203A	0.21
UCEC	chr2	10787359	Missense_Mutation	NA	A360V	0.44
UCEC	chr2	10789843	Missense_Mutation	rs529354043	P249L	0.41
UCEC	chr2	10837539	Missense_Mutation	novel	R23W	0.35
UCEC	chr2	10789822	Missense_Mutation	novel	R256Q	0.18
UCEC	chr2	10787357	Missense_Mutation	rs571578605	A361T	0.15

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	AMP	0.2305	0.099937
KIRP	DEL	0.0278	0.08832
LUSC	DEL	0.0599	0.20634
OV	DEL	0.1572	0.087942
PAAD	DEL	0.0924	0.2014
TGCT	AMP	0.28	0.0050216
UCEC	DEL	0.0353	0.18809

Survival Analysis

Cancer	P-value	Q-value
SARC	0.012	Kaplan-Meier Survival Analysis
MESO	0.02	Kaplan-Meier Survival Analysis
ACC	0.00049	Kaplan-Meier Survival Analysis
HNSC	0.00025	Kaplan-Meier Survival Analysis
KIRP	0.0061	Kaplan-Meier Survival Analysis
PAAD	0.0051	Kaplan-Meier Survival Analysis
BLCA	0.0034	Kaplan-Meier Survival Analysis
CESC	0.00028	Kaplan-Meier Survival Analysis
LIHC	0.00029	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
UVM	0.04	Kaplan-Meier Survival Analysis
OV	0.032	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000143870 (Gene tree)
Gene ID: 10130
Gene Symbol: PDIA6
Alias: P5|ERp5|TXNDC7
Full Name: protein disulfide isomerase family A member 6
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 54,587 bases
Position: chr2:10,783,391-10,837,977
Accession: 30168
RBP type: non-canonical RBP
Summary: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. This protein inhibits the aggregation of misfolded proteins and exhibits both isomerase and chaperone activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000404371	PDIA6-203	2682	-	ENSP00000385385	492 (aa)	-	Q15084
ENST00000458536	PDIA6-205	986	-	ENSP00000389558	11 (aa)	-	C9JNG5
ENST00000272227	PDIA6-201	2338	XM_011510308	ENSP00000272227	440 (aa)	XP_011508610	Q15084
ENST00000404824	PDIA6-204	2236	-	ENSP00000384459	488 (aa)	-	Q15084
ENST00000540494	PDIA6-207	2509	-	ENSP00000438778	437 (aa)	-	Q15084
ENST00000489662	PDIA6-206	564	-	-	- (aa)	-	-
ENST00000381611	PDIA6-202	2534	-	ENSP00000371024	445 (aa)	-	Q15084
ENST00000617249	PDIA6-208	2344	-	ENSP00000481892	492 (aa)	-	Q15084

Gene Model

Click here to download ENSG00000143870's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04141	Protein processing in endoplasmic reticulum	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000143870	Respiratory Function Tests	3.83836072893993E-5	17903307
ENSG00000143870	Osteoporosis	8.81822629021922E-5	17903295
ENSG00000143870	Platelet Function Tests	9.0396738E-006	-
ENSG00000143870	Education	4E-8	27225129
ENSG00000143870	Education	3E-8	27225129
ENSG00000143870	Eye Movements	4E-6	26242244
ENSG00000143870	Education	2E-10	27225129

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000143870	rs7590368	2	10821348	T	Educational attainment (years of education)	27225129	NR unit decrease	0.013930134	EFO_0004784
ENSG00000143870	rs76076331	2	10837459	T	Educational attainment (years of education)	27225129	NR unit increase	0.02040167	EFO_0004784
ENSG00000143870	rs76076331	2	10837459	T	Educational attainment (college completion)	27225129	[NR]	1.0468786	EFO_0004784
ENSG00000143870	rs4669634	2	10836701	A	Self-reported math ability	30038396	[0.01-0.018] unit decrease	0.0142	EFO_0004875
ENSG00000143870	rs76076331	2	10837459	T	Educational attainment (MTAG)	30038396	[0.016-0.024] unit increase	0.0201	EFO_0004784
ENSG00000143870	rs11885932	2	10833075	A	Highest math class taken	30038396	[0.015-0.031] unit decrease	0.0231	EFO_0004875
ENSG00000143870	rs4669634	2	10836701	A	Self-reported math ability (MTAG)	30038396	[0.012-0.019] unit decrease	0.0157	EFO_0004875
ENSG00000143870	rs76076331	2	10837459	T	Highest math class taken (MTAG)	30038396	[0.018-0.028] unit increase	0.0228	EFO_0004875
ENSG00000143870	rs4669634	2	10836701	A	Cognitive performance (MTAG)	30038396	[0.015-0.025] unit decrease	0.0198	EFO_0008354
ENSG00000143870	rs116156133	2	10812522	?	General cognitive ability	29844566	z-score increase	4.469	EFO_0004337
ENSG00000143870	rs7590368	2	10821348	T	Educational attainment (years of education)	30038396	[0.011-0.018] unit decrease	0.0146	EFO_0004784
ENSG00000143870	rs76076331	2	10837459	T	Educational attainment (years of education)	30038396	[0.016-0.025] unit increase	0.0206	EFO_0004784
ENSG00000143870	rs12474895	2	10817722	?	Educational attainment (years of education)	30595370			EFO_0004784

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000143870's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000143870	PDIA6	96	53.488	WBGene00015168	pdi-6	99	54.649	Caenorhabditis_elegans
ENSG00000143870	PDIA6	100	95.227	ENSMUSG00000020571	Pdia6	99	95.227	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003756	protein disulfide isomerase activity	-	IEA	Function
GO:0005515	protein binding	15466936.21057456.21670307.24189400.30021884.	IPI	Function
GO:0005615	extracellular space	19995400.	IDA	Component
GO:0005783	endoplasmic reticulum	-	IDA	Component
GO:0005783	endoplasmic reticulum	16130169.	TAS	Component
GO:0005788	endoplasmic reticulum lumen	-	TAS	Component
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	15308636.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005886	plasma membrane	-	IEA	Component
GO:0006457	protein folding	7590364.	TAS	Process
GO:0015037	peptide disulfide oxidoreductase activity	16677074.	IDA	Function
GO:0034663	endoplasmic reticulum chaperone complex	-	ISS	Component
GO:0036498	IRE1-mediated unfolded protein response	-	TAS	Process
GO:0042470	melanosome	-	IEA	Component
GO:0043687	post-translational protein modification	-	TAS	Process
GO:0044267	cellular protein metabolic process	-	TAS	Process
GO:0045454	cell redox homeostasis	-	IEA	Process
GO:0055114	oxidation-reduction process	-	IEA	Process
GO:0070062	extracellular exosome	20458337.	HDA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.