EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
26655997Restoration of miR-127-3p and miR-376a-3p counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells by targeting COA1, GLE1 and PDIA6.Cancer Lett2016 Feb 1Fellenberg Jdoi: 10.1016/j.canlet.2015.10.039
28866093MiR-127 and miR-376a act as tumor suppressors by invivo targeting of COA1 and PDIA6 in giant cell tumor of bone.Cancer Lett2017 Nov 28Herr Idoi: 10.1016/j.canlet.2017.08.029
27760590The Inhibitory Effect of PDIA6 Downregulation on Bladder Cancer Cell Proliferation and Invasion.Oncol Res2017 Apr 14Cheng HPdoi: 10.3727/096504016X14761811155298
24464223The protein disulfide isomerases PDIA4 and PDIA6 mediate resistance to cisplatin-induced cell death in lung adenocarcinoma.Cell Death Differ2014 MayTufo Gdoi: 10.1038/cdd.2013.193
26125904PDIA3 and PDIA6 gene expression as an aggressiveness marker in primary ductal breast cancer.Genet Mol Res2015 Jun 26Ramos FSdoi: 10.4238/2015.June.26.4.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr210790823Missense_MutationnovelE199Q0.17
BLCAchr210791918Missense_MutationnovelS154N0.19
BLCAchr210789794SilentnovelA265A0.3
BLCAchr210788953Missense_MutationnovelT290K0.2
BLCAchr210812690Missense_MutationNAL3F0.26
BLCAchr210784966Missense_MutationnovelE408Q0.62
BRCAchr210797733SilentnovelT62T0.1
CESCchr210819313Missense_MutationnovelP46A0.18
CESCchr210837536Missense_MutationnovelR24C0.39
CESCchr2108377285'UTRnovel0.47
CESCchr210802617SilentnovelL15L0.31
CESCchr210791822Missense_Mutationrs373388851Y186C0.39
COADchr210789851Silentrs779374855G246G0.15
COADchr210797125Missense_MutationNAI101T0.28
COADchr210802575Missense_MutationnovelE29K0.08
COADchr210793164Missense_MutationnovelS129G0.27
COADchr210793120Silentrs746420885S143S0.27
COADchr210797101Frame_Shift_DelnovelN109Tfs*160.33
COADchr210787345Missense_Mutationrs138012463R365C0.07
COADchr210790786Missense_MutationNAT211M0.31
COADchr210791828Missense_MutationnovelE184A0.09
COADchr210790812Silentrs769286711A202A0.44
COADchr210788901Silentrs143264920D307D0.43
COADchr210788738Frame_Shift_DelnovelY316Ffs*20.07
COADchr210784309SilentnovelD424D0.3
COADchr210789773Silentrs138784297N272N0.47
ESCAchr210790785SilentnovelT211T0.25
GBMchr210789789Missense_MutationnovelD267G0.06
GBMchr210789830Silentrs147509333D253D0.28
HNSCchr210802509Missense_MutationnovelY51N0.16
HNSCchr210802510Silentrs749186475F50F0.17
HNSCchr210791829Missense_MutationnovelE184Q0.15
HNSCchr2108127005'UTRnovel0.13
KIRCchr210793112Frame_Shift_DelnovelY146Qfs*90.14
KIRCchr210784300SilentNAL427L0.33
KIRCchr210791863Missense_MutationNAK172N0.27
KIRCchr210787422Missense_MutationnovelA339D0.4
KIRPchr210787403SilentNAL345L0.11
LGGchr210789851Silentrs779374855G246G0.25
LGGchr210788713Missense_MutationNAK328E0.19
LIHCchr210797121Missense_MutationnovelK102N0.29
LUADchr210787408Missense_MutationnovelE344Q0.07
LUADchr210789816Missense_MutationnovelR258K0.13
LUADchr210793158SilentNAL131L0.3
LUADchr210791877Missense_Mutationrs528723508D168N0.16
LUADchr210787345Missense_Mutationrs138012463R365C0.37
LUSCchr210797133Missense_MutationnovelF98L0.14
LUSCchr210788696Splice_SitenovelX333_splice0.43
LUSCchr210790785Silentrs145487229T211T0.11
LUSCchr210793121Frame_Shift_DelnovelS143Tfs*200.33
OVchr210784972Missense_MutationNAI406V0.48
OVchr210797097SilentnovelR110R0.08
PAADchr210791856Missense_MutationNAL175M0.3
PRADchr2108127175'UTRnovel0.5
PRADchr210793152Missense_MutationNAQ133E0.19
PRADchr210788922SilentNAA300A0.4
READchr210784970SilentNAI406I0.39
READchr210789862Missense_MutationnovelF243V0.11
READchr210788755Missense_MutationnovelN314H0.07
SKCMchr210784977Missense_MutationnovelP404L0.36
SKCMchr210784978Missense_MutationnovelP404S0.36
SKCMchr210787285Missense_MutationNAL385F0.25
SKCMchr210797163SilentNAS88S0.11
SKCMchr210787313SilentNAS375S0.39
SKCMchr210789806SilentNAI261I0.14
SKCMchr210787369Missense_MutationNAP357S0.09
STADchr210789851Silentrs779374855G246G0.19
STADchr210789843Missense_MutationNAP249H0.12
STADchr210789851Silentrs779374855G246G0.46
STADchr210790769Missense_MutationNAL217V0.21
STADchr210787396Missense_Mutationrs200773446A348T0.21
STADchr210788711SilentnovelK328K0.57
UCECchr210802510Missense_Mutationrs749186475F50L0.23
UCECchr210790800SilentnovelE206E0.26
UCECchr210789790Missense_MutationnovelD267Y0.08
UCECchr210788923Missense_MutationnovelA300D0.47
UCECchr210788973Silentrs189599067N283N0.41
UCECchr210791824Missense_MutationnovelF185L0.36
UCECchr210788746Missense_MutationnovelL317M0.09
UCECchr210802546Missense_MutationNAE38D0.45
UCECchr210787366Missense_Mutationrs187929195A358T0.25
UCECchr210787316SilentNAG374G0.17
UCECchr210802510Missense_Mutationrs749186475F50L0.09
UCECchr2108377475'UTRnovel0.5
UCECchr210787351Missense_MutationnovelN363D0.32
UCECchr210789843Missense_MutationNAP249H0.29
UCECchr210791852Missense_MutationnovelD176V0.52
UCECchr210787435SilentNAL335L0.25
UCECchr210791878Missense_MutationNAD167E0.23
UCECchr210802520Missense_MutationnovelL47R0.49
UCECchr210789806SilentNAI261I0.47
UCECchr210837526Missense_MutationnovelR27H0.46
UCECchr210789773Silentrs138784297N272N0.52
UCECchr210819342Missense_MutationnovelS36Y0.4
UCECchr210787351Missense_MutationnovelN363D0.35
UCECchr210819312Missense_MutationnovelP46L0.38
UCECchr2108208665'UTRnovel0.19
UCECchr210789773Silentrs138784297N272N0.26
UCECchr210788751Missense_MutationNAS315Y0.27
UCECchr210787285Missense_MutationnovelL385I0.23
UCECchr210789773Silentrs138784297N272N0.29
UCECchr210790809SilentnovelA203A0.21
UCECchr210787359Missense_MutationNAA360V0.44
UCECchr210789843Missense_Mutationrs529354043P249L0.41
UCECchr210837539Missense_MutationnovelR23W0.35
UCECchr210789822Missense_MutationnovelR256Q0.18
UCECchr210787357Missense_Mutationrs571578605A361T0.15

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
CESCAMP0.23050.099937
KIRPDEL0.02780.08832
LUSCDEL0.05990.20634
OVDEL0.15720.087942
PAADDEL0.09240.2014
TGCTAMP0.280.0050216
UCECDEL0.03530.18809

Survival Analysis
CancerP-value Q-value
SARC0.012

Kaplan-Meier Survival Analysis

MESO0.02

Kaplan-Meier Survival Analysis

ACC0.00049

Kaplan-Meier Survival Analysis

HNSC0.00025

Kaplan-Meier Survival Analysis

KIRP0.0061

Kaplan-Meier Survival Analysis

PAAD0.0051

Kaplan-Meier Survival Analysis

BLCA0.0034

Kaplan-Meier Survival Analysis

CESC0.00028

Kaplan-Meier Survival Analysis

LIHC0.00029

Kaplan-Meier Survival Analysis

LGG0.0001

Kaplan-Meier Survival Analysis

UVM0.04

Kaplan-Meier Survival Analysis

OV0.032

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000143870 (Gene tree)
Gene ID
10130
Gene Symbol
PDIA6
Alias
P5|ERp5|TXNDC7
Full Name
protein disulfide isomerase family A member 6
Gene Type
protein_coding
Species
Homo_sapiens
Status
putative
Strand
Minus strand
Length
54,587 bases
Position
chr2:10,783,391-10,837,977
Accession
30168
RBP type
non-canonical RBP
Summary
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. This protein inhibits the aggregation of misfolded proteins and exhibits both isomerase and chaperone activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000404371PDIA6-2032682-ENSP00000385385492 (aa)-Q15084
ENST00000458536PDIA6-205986-ENSP0000038955811 (aa)-C9JNG5
ENST00000272227PDIA6-2012338XM_011510308ENSP00000272227440 (aa)XP_011508610Q15084
ENST00000404824PDIA6-2042236-ENSP00000384459488 (aa)-Q15084
ENST00000540494PDIA6-2072509-ENSP00000438778437 (aa)-Q15084
ENST00000489662PDIA6-206564--- (aa)--
ENST00000381611PDIA6-2022534-ENSP00000371024445 (aa)-Q15084
ENST00000617249PDIA6-2082344-ENSP00000481892492 (aa)-Q15084
Gene Model
Click here to download ENSG00000143870's gene model file
Pathways
Pathway IDPathway NameSource
hsa04141Protein processing in endoplasmic reticulumKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000143870Respiratory Function Tests3.83836072893993E-517903307
ENSG00000143870Osteoporosis8.81822629021922E-517903295
ENSG00000143870Platelet Function Tests9.0396738E-006-
ENSG00000143870Education4E-827225129
ENSG00000143870Education3E-827225129
ENSG00000143870Eye Movements4E-626242244
ENSG00000143870Education2E-1027225129
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000143870rs7590368210821348TEducational attainment (years of education)27225129NR unit decrease0.013930134EFO_0004784
ENSG00000143870rs76076331210837459TEducational attainment (years of education)27225129NR unit increase0.02040167EFO_0004784
ENSG00000143870rs76076331210837459TEducational attainment (college completion)27225129[NR]1.0468786EFO_0004784
ENSG00000143870rs4669634210836701ASelf-reported math ability30038396[0.01-0.018] unit decrease0.0142EFO_0004875
ENSG00000143870rs76076331210837459TEducational attainment (MTAG)30038396[0.016-0.024] unit increase0.0201EFO_0004784
ENSG00000143870rs11885932210833075AHighest math class taken30038396[0.015-0.031] unit decrease0.0231EFO_0004875
ENSG00000143870rs4669634210836701ASelf-reported math ability (MTAG)30038396[0.012-0.019] unit decrease0.0157EFO_0004875
ENSG00000143870rs76076331210837459THighest math class taken (MTAG)30038396[0.018-0.028] unit increase0.0228EFO_0004875
ENSG00000143870rs4669634210836701ACognitive performance (MTAG)30038396[0.015-0.025] unit decrease0.0198EFO_0008354
ENSG00000143870rs116156133210812522?General cognitive ability29844566z-score increase4.469EFO_0004337
ENSG00000143870rs7590368210821348TEducational attainment (years of education)30038396[0.011-0.018] unit decrease0.0146EFO_0004784
ENSG00000143870rs76076331210837459TEducational attainment (years of education)30038396[0.016-0.025] unit increase0.0206EFO_0004784
ENSG00000143870rs12474895210817722?Educational attainment (years of education)30595370EFO_0004784
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000143870's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000143870PDIA69653.488WBGene00015168pdi-69954.649Caenorhabditis_elegans
ENSG00000143870PDIA610095.227ENSMUSG00000020571Pdia69995.227Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003756protein disulfide isomerase activity-IEAFunction
GO:0005515protein binding15466936.21057456.21670307.24189400.30021884.IPIFunction
GO:0005615extracellular space19995400.IDAComponent
GO:0005783endoplasmic reticulum-IDAComponent
GO:0005783endoplasmic reticulum16130169.TASComponent
GO:0005788endoplasmic reticulum lumen-TASComponent
GO:0005789endoplasmic reticulum membrane-TASComponent
GO:0005793endoplasmic reticulum-Golgi intermediate compartment15308636.IDAComponent
GO:0005829cytosol-IDAComponent
GO:0005886plasma membrane-IEAComponent
GO:0006457protein folding7590364.TASProcess
GO:0015037peptide disulfide oxidoreductase activity16677074.IDAFunction
GO:0034663endoplasmic reticulum chaperone complex-ISSComponent
GO:0036498IRE1-mediated unfolded protein response-TASProcess
GO:0042470melanosome-IEAComponent
GO:0043687post-translational protein modification-TASProcess
GO:0044267cellular protein metabolic process-TASProcess
GO:0045454cell redox homeostasis-IEAProcess
GO:0055114oxidation-reduction process-IEAProcess
GO:0070062extracellular exosome20458337.HDAComponent
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