EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26517679	Targeting stemness is an effective strategy to control EML4-ALK+ non-small cell lung cancer cells.	Oncotarget	2015 Nov 24	Oh SJ	doi: 10.18632/oncotarget.5434.
19737969	Exon array profiling detects EML4-ALK fusion in breast, colorectal, and non-small cell lung cancers.	Mol Cancer Res	2009 Sep	Lin E	doi: 10.1158/1541-7786.MCR-08-0522
27507192	Expanded Circulating Tumor Cells from a Patient with ALK-Positive Lung Cancer Present with EML4-ALK Rearrangement Along with Resistance Mutation and Enable Drug Sensitivity Testing: A Case Study.	J Thorac Oncol	2017 Feb	Zhang Z	doi: 10.1016/j.jtho.2016.07.027
24633422	Whole-genome sequencing of an aggressive BRAF wild-type papillary thyroid cancer identified EML4-ALK translocation as a therapeutic target.	World J Surg	2014 Jun	Demeure MJ	doi: 10.1007/s00268-014-2485-3.
20183914	Clinicopathologic features of non-small-cell lung cancer with EML4-ALK fusion gene.	Ann Surg Oncol	2010 Mar	Takahashi T	doi: 10.1245/s10434-009-0808-7.
18594010	EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer.	Clin Cancer Res	2008 Jul 1	Koivunen JP	doi: 10.1158/1078-0432.CCR-08-0168.
26704814	Second Primary Lung Adenocarcinoma Harboring EML4-ALK After Surgically Resected EGFR Positive Lung Adenocarcinoma.	Clin Lung Cancer	2016 Mar	Takenaka T	doi: 10.1016/j.cllc.2015.11.005
19147828	EML4-ALK rearrangement in non-small cell lung cancer and non-tumor lung tissues.	Am J Pathol	2009 Feb	Martelli MP	doi: 10.2353/ajpath.2009.080755
18927303	Multiplex reverse transcription-PCR screening for EML4-ALK fusion transcripts.	Clin Cancer Res	2008 Oct 15	Takeuchi K	doi: 10.1158/1078-0432.CCR-08-1018.
21356191	Exon scanning by reverse transcriptase-polymerase chain reaction for detection of known and novel EML4-ALK fusion variants in non-small cell lung cancer.	Cancer Genet	2011 Jan	Sanders HR	doi: 10.1016/j.cancergencyto.2010.08.024.
20578368	[Discovery of EML4-ALK, a new gene responsible for lung cancer, and the development of molecular targeted therapy].	Nihon Naika Gakkai Zasshi	2010 Apr 10	Mano H	-
22056890	Successful long-term treatment with pemetrexed of NSCLC associated with EML4-ALK and low thymidylate synthase expression.	Clin Lung Cancer	2012 Mar	Takeda M	doi: 10.1016/j.cllc.2011.09.003
26755435	Molecular mechanisms that underpin EML4-ALK driven cancers and their response to targeted drugs.	Cell Mol Life Sci	2016 Mar	Bayliss R	doi: 10.1007/s00018-015-2117-6
23154565	First case of combined small-cell lung cancer with adenocarcinoma harboring EML4-ALK fusion and an exon 19 EGFR mutation in each histological component.	J Thorac Oncol	2012 Dec	Toyokawa G	doi: 10.1097/JTO.0b013e3182762bcb.
22722791	A novel mass spectrometry-based assay for diagnosis of EML4-ALK-positive non-small cell lung cancer.	J Thorac Oncol	2012 May	Sakai K	doi: 10.1097/JTO.0b013e31824c7f7a.
24952482	Receptor ligand-triggered resistance to alectinib and its circumvention by Hsp90 inhibition in EML4-ALK lung cancer cells.	Oncotarget	2014 Jul 15	Tanimoto A	-
23169500	Severe acute interstitial lung disease after crizotinib therapy in a patient with EML4-ALK-positive non-small-cell lung cancer.	J Clin Oncol	2013 Jan 1	Tamiya A	doi: 10.1200/JCO.2012.43.3730
25721120	Fluorescence in situ hybridization, immunohistochemistry, and next-generation sequencing for detection of EML4-ALK rearrangement in lung cancer.	Oncologist	2015 Mar	Pekar-Zlotin M	doi: 10.1634/theoncologist.2014-0389
22706607	A novel EML4-ALK variant: exon 6 of EML4 fused to exon 19 of ALK.	J Thorac Oncol	2012 Jul	Penzel R	doi: 10.1097/JTO.0b013e3182598af3.
18593892	Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer.	Cancer Res	2008 Jul 1	Choi YL	doi: 10.1158/0008-5472.CAN-07-6158.
26964537	Ground-glass nodule in a patient with echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK)-positive lung cancer: a case report.	World J Surg Oncol	2016 Mar 10	Owada Y	doi: 10.1186/s12957-016-0841-5.
28039177	Differential protein stability and clinical responses of EML4-ALK fusion variants to various ALK inhibitors in advanced ALK-rearranged non-small cell lung cancer.	Ann Oncol	2017 Apr 1	Woo CG	doi: 10.1093/annonc/mdw693.
29363116	EML4-ALK fusion variant V3 is a high-risk feature conferring accelerated metastatic spread, early treatment failure and worse overall survival in ALK+ non-small cell lung cancer.	Int J Cancer	2018 Jun 15	Christopoulos P	doi: 10.1002/ijc.31275
30236141	Circular RNA F-circEA-2a derived from EML4-ALK fusion gene promotes cell migration and invasion in non-small cell lung cancer.	Mol Cancer	2018 Sep 20	Tan S	doi: 10.1186/s12943-018-0887-9.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr2	42169623	Silent	novel	F4F	0.21
BLCA	chr2	42328901	Missense_Mutation	novel	G786V	0.1
BLCA	chr2	42295151	Silent	novel	V415V	0.25
BLCA	chr2	42261161	Nonsense_Mutation	novel	E127*	0.4
BLCA	chr2	42286288	Missense_Mutation	novel	R344T	0.23
BLCA	chr2	42263189	Missense_Mutation	novel	P175L	0.28
BLCA	chr2	42245532	Missense_Mutation	novel	S18Y	0.36
BRCA	chr2	42245684	Nonsense_Mutation	NA	K69*	0.2
BRCA	chr2	42303155	Nonsense_Mutation	NA	Q565*	0.35
BRCA	chr2	42245601	Frame_Shift_Ins	novel	*A43Gfs5**	0.23
BRCA	chr2	42330128	Missense_Mutation	NA	E956V	0.38
BRCA	chr2	42331165	3'UTR	novel		0.45
BRCA	chr2	42261308	Intron	novel		0.17
BRCA	chr2	42317426	Splice_Site	NA	X686_splice	0.22
BRCA	chr2	42303325	Missense_Mutation	NA	D593G	0.38
CESC	chr2	42331361	3'UTR	novel		0.08
CESC	chr2	42331568	3'UTR	novel		0.44
CESC	chr2	42263264	Nonsense_Mutation	NA	S200*	0.35
CESC	chr2	42330744	3'UTR	rs550561004		0.3
CESC	chr2	42329835	Silent	novel	S858S	0.5
CESC	chr2	42261416	Intron	novel		0.17
CESC	chr2	42261418	Intron	novel		0.17
CESC	chr2	42331293	3'UTR	novel		0.42
CESC	chr2	42286132	Intron	novel		0.17
CESC	chr2	42303120	Missense_Mutation	novel	G553D	0.14
CESC	chr2	42304518	Missense_Mutation	novel	G645D	0.39
CESC	chr2	42332217	3'UTR	novel		0.4
CESC	chr2	42330881	3'UTR	novel		0.29
CESC	chr2	42330431	3'UTR	novel		0.19
COAD	chr2	42303145	Frame_Shift_Del	NA	*K562Rfs6**	0.07
COAD	chr2	42263261	Missense_Mutation	NA	P199H	0.14
COAD	chr2	42329919	Silent	NA	V886V	0.42
COAD	chr2	42328935	Silent	NA	R797R	0.2
COAD	chr2	42295518	Splice_Site	NA	X497_splice	0.24
COAD	chr2	42256544	Silent	NA	T84T	0.4
COAD	chr2	42301354	Missense_Mutation	NA	L535M	0.25
COAD	chr2	42261162	Frame_Shift_Del	rs770453803	*E130Rfs43**	0.35
COAD	chr2	42288258	Missense_Mutation	NA	D385V	0.14
COAD	chr2	42329892	Silent	rs766491420	A877A	0.14
COAD	chr2	42282871	Silent	rs372736784	P280P	0.11
COAD	chr2	42261162	Frame_Shift_Del	rs770453803	*E130Rfs43**	0.15
COAD	chr2	42282875	Missense_Mutation	rs573955552	G282R	0.22
COAD	chr2	42261162	Frame_Shift_Del	NA	*K129Rfs6**	0.51
COAD	chr2	42256591	Nonsense_Mutation	NA	S100*	0.4
DLBC	chr2	42330345	3'UTR	novel		0.36
ESCA	chr2	42263298	Silent	novel	T211T	0.27
ESCA	chr2	42329981	Missense_Mutation	novel	N907S	0.52
ESCA	chr2	42329981	Missense_Mutation	novel	N907S	0.23
ESCA	chr2	42284685	Silent	rs566921568	G331G	0.14
ESCA	chr2	42329891	Missense_Mutation	rs756245593	A877V	0.26
ESCA	chr2	42330767	3'UTR	novel		0.18
ESCA	chr2	42331349	3'UTR	novel		0.35
ESCA	chr2	42332403	3'UTR	novel		0.1
ESCA	chr2	42280951	Missense_Mutation	novel	E257Q	0.18
ESCA	chr2	42280889	Missense_Mutation	novel	I236N	0.28
ESCA	chr2	42330878	3'UTR	novel		0.33
GBM	chr2	42329919	Silent	novel	V886V	0.59
GBM	chr2	42329760	Missense_Mutation	novel	H833Q	0.1
GBM	chr2	42263216	Missense_Mutation	novel	S184Y	0.2
GBM	chr2	42316000	Missense_Mutation	novel	S669Y	0.29
GBM	chr2	42329827	Missense_Mutation	NA	D856Y	0.2
GBM	chr2	42303333	Missense_Mutation	novel	W596R	0.09
HNSC	chr2	42326243	Missense_Mutation	novel	Q778E	0.14
HNSC	chr2	42329860	Missense_Mutation	novel	K867Q	0.29
HNSC	chr2	42329757	Silent	rs201235905	A832A	0.07
HNSC	chr2	42329960	Missense_Mutation	novel	P900R	0.2
HNSC	chr2	42330195	Silent	rs147316565	S978S	0.27
HNSC	chr2	42304539	Missense_Mutation	novel	T652K	0.17
HNSC	chr2	42303180	In_Frame_Ins	novel	N573delinsKPKFGYGNL	0.08
HNSC	chr2	42286157	Intron	novel		0.15
HNSC	chr2	42245566	Silent	novel	S29S	0.33
KIRC	chr2	42245565	Nonsense_Mutation	NA	S29*	0.15
KIRP	chr2	42261280	Silent	NA	A166A	0.27
KIRP	chr2	42330249	3'UTR	novel		0.15
LAML	chr2	42295443	Silent	novel	T472T	0.12
LGG	chr2	42326190	Missense_Mutation	NA	R760L	0.18
LIHC	chr2	42261206	Nonsense_Mutation	rs760391629	R142*	0.16
LIHC	chr2	42329992	Missense_Mutation	novel	E911K	0.46
LIHC	chr2	42328918	Missense_Mutation	novel	I792F	0.18
LIHC	chr2	42303387	Missense_Mutation	NA	R614W	0.43
LUAD	chr2	42261288	Missense_Mutation	rs776611036	T169I	0.11
LUAD	chr2	42263242	Frame_Shift_Del	novel	*N193Ifs12**	0.14
LUAD	chr2	42261164	Missense_Mutation	NA	K128E	0.54
LUAD	chr2	42303178	Silent	NA	R572R	0.14
LUAD	chr2	42295380	Splice_Site	NA	X452_splice	0.33
LUAD	chr2	42261179	Missense_Mutation	NA	H133D	0.07
LUAD	chr2	42284695	Missense_Mutation	NA	D335H	0.18
LUAD	chr2	42328922	Missense_Mutation	rs771053246	N793S	0.18
LUSC	chr2	42282957	Missense_Mutation	novel	T309R	0.19
LUSC	chr2	42169603	5'UTR	novel		0.11
LUSC	chr2	42282923	Nonsense_Mutation	novel	E298*	0.11
LUSC	chr2	42256515	Nonsense_Mutation	NA	R75*	0.29
LUSC	chr2	42317500	Silent	novel	K710K	0.16
LUSC	chr2	42284690	Missense_Mutation	novel	D333A	0.22
OV	chr2	42330241	3'UTR	novel		0.25
OV	chr2	42245572	Silent	novel	V31V	0.08
OV	chr2	42330142	Missense_Mutation	novel	I961L	0.19
OV	chr2	42330257	3'UTR	novel		0.09
OV	chr2	42317484	Missense_Mutation	novel	S705Y	0.1
OV	chr2	42330309	3'UTR	novel		0.5
OV	chr2	42295142	Silent	NA	V412V	0.58
OV	chr2	42329799	Silent	novel	D846D	0.05
OV	chr2	42330382	3'UTR	novel		0.42
OV	chr2	42329742	Missense_Mutation	novel	S827R	0.11
OV	chr2	42169623	Silent	novel	F4F	0.09
OV	chr2	42263240	Missense_Mutation	rs369448526	R192H	0.14
OV	chr2	42328968	Nonsense_Mutation	novel	D808_D809ins*	0.12
OV	chr2	42328969	In_Frame_Ins	novel	D809delinsGNNFHLN	0.1
OV	chr2	42328888	Missense_Mutation	NA	V782L	0.11
OV	chr2	42329792	In_Frame_Del	novel	N845_D846del	0.05
OV	chr2	42330190	Missense_Mutation	novel	P977T	0.04
OV	chr2	42263210	Missense_Mutation	NA	H182R	0.33
PAAD	chr2	42286284	Missense_Mutation	rs146370925	V343I	0.26
PAAD	chr2	42304533	Missense_Mutation	novel	I650K	0.43
PRAD	chr2	42295407	Missense_Mutation	novel	Q460H	0.16
PRAD	chr2	42316047	Missense_Mutation	NA	I685L	0.31
PRAD	chr2	42286269	Missense_Mutation	NA	P338S	0.38
PRAD	chr2	42245543	Missense_Mutation	novel	D22Y	0.09
READ	chr2	42169607	5'UTR	rs370083781		0.42
READ	chr2	42329941	Missense_Mutation	novel	Q894K	0.07
READ	chr2	42245590	Silent	novel	E37E	0.3
READ	chr2	42286161	Intron	novel		0.48
READ	chr2	42328884	Splice_Site	novel	X781_splice	0.41
SARC	chr2	42331237	3'UTR	novel		0.38
SARC	chr2	42295239	Missense_Mutation	novel	R445G	0.08
SARC	chr2	42295223	Silent	rs201724206	S439S	0.33
SKCM	chr2	42295207	Missense_Mutation	novel	F434C	0.13
SKCM	chr2	42317493	Missense_Mutation	NA	G708E	0.29
SKCM	chr2	42245634	Missense_Mutation	NA	L52P	0.26
SKCM	chr2	42315972	Silent	rs769058958	L660L	0.38
SKCM	chr2	42315988	Missense_Mutation	NA	R665K	0.3
SKCM	chr2	42329943	Silent	NA	Q894Q	0.47
SKCM	chr2	42304527	Missense_Mutation	NA	V648G	0.54
SKCM	chr2	42328901	Missense_Mutation	novel	G786E	0.54
SKCM	chr2	42261179	Missense_Mutation	NA	H133Y	0.45
SKCM	chr2	42280864	Missense_Mutation	NA	K228E	0.46
SKCM	chr2	42261415	Intron	novel		0.29
SKCM	chr2	42326162	Missense_Mutation	NA	P751S	0.44
STAD	chr2	42261162	Frame_Shift_Del	rs770453803	*E130Rfs43**	0.34
STAD	chr2	42295492	Missense_Mutation	NA	P489S	0.08
STAD	chr2	42263239	Missense_Mutation	rs376838322	R192C	0.31
STAD	chr2	42263232	Missense_Mutation	novel	D189E	0.13
STAD	chr2	42261162	Frame_Shift_Del	rs770453803	*E130Rfs43**	0.29
STAD	chr2	42280919	Missense_Mutation	NA	N246S	0.1
STAD	chr2	42261161	Frame_Shift_Del	novel	*E127Kfs46**	0.27
THCA	chr2	42303205	In_Frame_Ins	novel	N581_D582insYT	0.08
THCA	chr2	42282913	Silent	rs771009098	L294L	0.05
THCA	chr2	42330276	3'UTR	novel		0.12
THYM	chr2	42330645	3'UTR	novel		0.21
THYM	chr2	42263204	Missense_Mutation	novel	K180R	0.07
THYM	chr2	42295475	Missense_Mutation	novel	S483I	0.07
UCEC	chr2	42329762	Missense_Mutation	NA	S834N	0.3
UCEC	chr2	42288298	Silent	NA	K398K	0.31
UCEC	chr2	42263209	Missense_Mutation	novel	H182Y	0.3
UCEC	chr2	42263284	Missense_Mutation	NA	K207Q	0.11
UCEC	chr2	42332230	3'UTR	novel		0.48
UCEC	chr2	42261161	Frame_Shift_Ins	novel	*E130Rfs6**	0.44
UCEC	chr2	42331408	3'UTR	rs577138437		0.43
UCEC	chr2	42330618	3'UTR	novel		0.18
UCEC	chr2	42245631	Missense_Mutation	rs763325044	R51H	0.39
UCEC	chr2	42286039	Intron	novel		0.3
UCEC	chr2	42288298	Missense_Mutation	NA	K398N	0.47
UCEC	chr2	42303177	Missense_Mutation	novel	R572Q	0.33
UCEC	chr2	42280887	Silent	novel	P235P	0.36
UCEC	chr2	42286336	Missense_Mutation	novel	G360D	0.23
UCEC	chr2	42286126	Intron	novel		0.16
UCEC	chr2	42330868	3'UTR	novel		0.28
UCEC	chr2	42261162	Frame_Shift_Del	rs770453803	*E130Rfs43**	0.54
UCEC	chr2	42295134	Missense_Mutation	NA	E410K	0.26
UCEC	chr2	42316014	Missense_Mutation	NA	G674R	0.25
UCEC	chr2	42329961	Silent	NA	P900P	0.24
UCEC	chr2	42328885	Splice_Site	novel	X781_splice	0.19
UCEC	chr2	42326217	Missense_Mutation	rs150527843	T769M	0.28
UCEC	chr2	42328961	Missense_Mutation	NA	V806A	0.41
UCEC	chr2	42329950	Missense_Mutation	NA	T897A	0.4
UCEC	chr2	42282820	Splice_Region	rs748896137		0.31
UCEC	chr2	42245682	Missense_Mutation	novel	S68N	0.39
UCEC	chr2	42261162	Frame_Shift_Del	rs770453803	*E130Rfs43**	0.33
UCEC	chr2	42331236	3'UTR	novel		0.4
UCEC	chr2	42332123	3'UTR	novel		0.5
UCEC	chr2	42330574	3'UTR	novel		0.31
UCEC	chr2	42331684	3'UTR	novel		0.19
UCEC	chr2	42331237	3'UTR	novel		0.22
UCEC	chr2	42169468	5'UTR	novel		0.44
UCEC	chr2	42331545	3'UTR	novel		0.27
UCEC	chr2	42331649	3'UTR	novel		0.51
UCEC	chr2	42326194	Silent	rs146276222	S761S	0.52
UCEC	chr2	42331236	3'UTR	novel		0.31
UCEC	chr2	42331409	3'UTR	novel		0.49
UCEC	chr2	42263182	Missense_Mutation	novel	K173Q	0.35
UCEC	chr2	42331214	3'UTR	novel		0.44
UCEC	chr2	42331605	3'UTR	novel		0.58
UCEC	chr2	42332524	3'UTR	novel		0.46
UCEC	chr2	42330301	3'UTR	novel		0.49
UCEC	chr2	42261162	Frame_Shift_Del	rs770453803	*E130Rfs43**	0.42
UCEC	chr2	42284686	Missense_Mutation	NA	V332M	0.41
UCEC	chr2	42329858	Frame_Shift_Del	novel	*K867Sfs10**	0.46
UCEC	chr2	42331182	3'UTR	novel		0.31
UCEC	chr2	42331422	3'UTR	novel		0.29
UCEC	chr2	42261162	Frame_Shift_Del	rs770453803	*E130Rfs43**	0.17
UCEC	chr2	42331237	3'UTR	novel		0.25
UCEC	chr2	42331518	3'UTR	novel		0.26
UCEC	chr2	42169442	5'UTR	novel		0.25
UCEC	chr2	42288306	Missense_Mutation	novel	K401T	0.41
UCEC	chr2	42331273	3'UTR	novel		0.2
UCEC	chr2	42331533	3'UTR	novel		0.21
UCEC	chr2	42329960	Missense_Mutation	rs201541248	P900L	0.09
UCEC	chr2	42286230	Intron	novel		0.3
UCEC	chr2	42286225	Intron	novel		0.42
UCEC	chr2	42330221	3'UTR	novel		0.15
UCEC	chr2	42331901	3'UTR	novel		0.27
UCEC	chr2	42245568	Missense_Mutation	rs144376390	R30Q	0.46
UCEC	chr2	42328915	Missense_Mutation	novel	D791Y	0.47
UCEC	chr2	42331273	3'UTR	novel		0.31
UCEC	chr2	42169386	5'UTR	novel		0.6
UCEC	chr2	42282939	Missense_Mutation	rs775548568	R303Q	0.31
UCEC	chr2	42315990	Missense_Mutation	NA	D666Y	0.16
UCEC	chr2	42303135	Missense_Mutation	novel	V558A	0.33
UCEC	chr2	42169511	5'UTR	novel		0.32
UCEC	chr2	42331237	3'UTR	novel		0.19
UCEC	chr2	42332491	3'UTR	novel		0.15
UCEC	chr2	42331273	3'UTR	novel		0.38
UCEC	chr2	42301354	Missense_Mutation	NA	L535M	0.4
UCEC	chr2	42301354	Missense_Mutation	NA	L535M	0.39
UCEC	chr2	42245608	Silent	rs143234265	A43A	0.08
UCEC	chr2	42280855	Nonsense_Mutation	novel	E225*	0.28
UCEC	chr2	42282834	Missense_Mutation	rs771961171	R268Q	0.29
UCEC	chr2	42329973	Missense_Mutation	novel	Q904H	0.04
UCEC	chr2	42261162	Frame_Shift_Del	rs770453803	*E130Rfs43**	0.36
UCEC	chr2	42330587	3'UTR	novel		0.52
UCEC	chr2	42303177	Missense_Mutation	novel	R572Q	0.32
UCS	chr2	42295256	Missense_Mutation	rs755601518	F450L	0.16

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	AMP	0.2271	0.099937
COAD	DEL	0.0244	0.15521
KIRP	DEL	0.0243	0.08832
PAAD	DEL	0.0707	0.2014
PRAD	DEL	0.0711	0.096106
TGCT	AMP	0.26	0.0050216

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00039	Kaplan-Meier Survival Analysis
SARC	0.0029	Kaplan-Meier Survival Analysis
MESO	0.027	Kaplan-Meier Survival Analysis
ACC	0.00012	Kaplan-Meier Survival Analysis
HNSC	0.03	Kaplan-Meier Survival Analysis
PRAD	0.018	Kaplan-Meier Survival Analysis
KIRP	0.037	Kaplan-Meier Survival Analysis
READ	0.016	Kaplan-Meier Survival Analysis
KICH	0.034	Kaplan-Meier Survival Analysis
UCEC	0.005	Kaplan-Meier Survival Analysis
LIHC	0.023	Kaplan-Meier Survival Analysis
LUAD	0.015	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000143924 (Gene tree)
Gene ID: 27436
Gene Symbol: EML4
Alias: ROPP120|ELP120|C2orf2
Full Name: EMAP like 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 163,211 bases
Position: chr2:42,169,338-42,332,548
Accession: 1316
RBP type: non-canonical RBP
Summary: This gene is a member of the echinoderm microtubule associated protein-like family. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, which generates EML4-ALK fusion transcripts, is one of the primary mutations associated with non-small cell lung cancer. Alternative splicing of this gene results in two transcript variants. [provided by RefSeq, Jan 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000409040	EML4-205	962	-	-	- (aa)	-	-
ENST00000406175	EML4-204	4622	-	-	- (aa)	-	-
ENST00000472632	EML4-206	515	-	-	- (aa)	-	-
ENST00000482660	EML4-208	584	-	-	- (aa)	-	-
ENST00000318522	EML4-201	5549	-	ENSP00000320663	981 (aa)	-	Q9HC35
ENST00000480320	EML4-207	1932	-	-	- (aa)	-	-
ENST00000402711	EML4-203	3568	-	ENSP00000385059	923 (aa)	-	Q9HC35
ENST00000401738	EML4-202	3797	XM_005264267	ENSP00000384939	992 (aa)	XP_005264324	B5MBZ0

Gene Model

Click here to download ENSG00000143924's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa05200	Pathways in cancer	KEGG
hsa05223	Non-small cell lung cancer	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000143924	Platelet Function Tests	1.6002700E-005	-
ENSG00000143924	Platelet Function Tests	1.8452048E-006	-
ENSG00000143924	Platelet Function Tests	1.9481200E-005	-
ENSG00000143924	Platelet Function Tests	2.1117307E-006	-
ENSG00000143924	Platelet Function Tests	2.3937400E-005	-
ENSG00000143924	Platelet Function Tests	1.6044200E-005	-
ENSG00000143924	Platelet Function Tests	1.8530790E-006	-
ENSG00000143924	Platelet Function Tests	1.9556000E-005	-
ENSG00000143924	Platelet Function Tests	2.1177826E-006	-
ENSG00000143924	Platelet Function Tests	2.3995600E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000143924	rs10193935	2	42192689	?	Colonoscopy-negative controls vs population controls	29228715	[NR]	1.532	EFO_0008460
ENSG00000143924	rs12995492	2	42227321	?	Reaction time	29844566	[0.0043-0.0112] unit decrease	0.0077523	EFO_0008393
ENSG00000143924	rs6736913	2	42282878	A	Infantile hypertrophic pyloric stenosis	30281099	[2.11-2.53]	2.32	EFO_0004707
ENSG00000143924	rs10460533	2	42267214	?	Lung function (FEV1/FVC)	30595370			EFO_0004713

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000143924's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000226	microtubule cytoskeleton organization	21873635.	IBA	Process
GO:0000278	mitotic cell cycle	10995578.	NAS	Process
GO:0003674	molecular_function	-	ND	Function
GO:0005737	cytoplasm	10995578.	NAS	Component
GO:0005874	microtubule	-	IEA	Component
GO:0007017	microtubule-based process	10995578.	NAS	Process
GO:0008017	microtubule binding	21873635.	IBA	Function
GO:0015630	microtubule cytoskeleton	21873635.	IBA	Component
GO:0016020	membrane	19946888.	HDA	Component

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.