EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr2	112254937	Silent	novel	L15L	0.21
CESC	chr2	112254961	Missense_Mutation	NA	F7L	0.31
CESC	chr2	112238442	Frame_Shift_Del	novel	*C82Afs37**	0.07
CESC	chr2	112238400	Silent	rs769632919	Q95Q	0.19
CESC	chr2	112236599	Nonsense_Mutation	novel	S156*	0.16
COAD	chr2	112236574	Silent	novel	G164G	0.09
COAD	chr2	112238399	Nonsense_Mutation	NA	Q96*	0.26
COAD	chr2	112255080	5'UTR	novel		0.17
ESCA	chr2	112250268	Missense_Mutation	novel	D27Y	0.11
GBM	chr2	112254926	Missense_Mutation	novel	A19V	0.12
GBM	chr2	112254978	Missense_Mutation	rs755659882	D2N	0.53
HNSC	chr2	112231879	Missense_Mutation	rs748316181	H268Y	0.19	zf-CCCH
HNSC	chr2	112236630	Nonsense_Mutation	novel	R146*	0.13
LIHC	chr2	112231933	Missense_Mutation	NA	K250Q	0.34	zf-CCCH
LUSC	chr2	112236568	Missense_Mutation	novel	Q166H	0.18
LUSC	chr2	112236627	Missense_Mutation	novel	K147E	0.09
LUSC	chr2	112254907	Splice_Site	novel	X25_splice	0.21
OV	chr2	112236606	Nonsense_Mutation	novel	K154*	0.16
SARC	chr2	112255039	5'UTR	novel		0.11
SKCM	chr2	112254917	Missense_Mutation	novel	S22F	0.42
STAD	chr2	112236630	Nonsense_Mutation	novel	R146*	0.2
STAD	chr2	112254926	Missense_Mutation	novel	A19V	0.35
STAD	chr2	112234170	Missense_Mutation	rs371803574	R191C	0.08
UCEC	chr2	112238387	Missense_Mutation	novel	A100T	0.08
UCEC	chr2	112234210	Silent	novel	Q177Q	0.27
UCEC	chr2	112255010	5'UTR	novel		0.48
UCEC	chr2	112231883	Missense_Mutation	NA	F266L	0.1	zf-CCCH
UCEC	chr2	112254970	Missense_Mutation	NA	E4D	0.43
UCEC	chr2	112254966	Missense_Mutation	novel	L6I	0.27
UCEC	chr2	112238525	Missense_Mutation	novel	R54G	0.37
UCEC	chr2	112234170	Missense_Mutation	rs371803574	R191C	0.32
UCEC	chr2	112250269	Silent	rs762242170	I26I	0.33
UCEC	chr2	112238346	Silent	novel	T113T	0.56
UCEC	chr2	112238519	Missense_Mutation	NA	S56P	0.16
UCEC	chr2	112254988	5'UTR	novel		0.39
UCS	chr2	112234149	Missense_Mutation	novel	K198Q	0.5

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1778	0.15279
PAAD	DEL	0.038	0.2014

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0071	Kaplan-Meier Survival Analysis
STAD	0.017	Kaplan-Meier Survival Analysis
MESO	0.011	Kaplan-Meier Survival Analysis
ACC	0.00049	Kaplan-Meier Survival Analysis
HNSC	0.049	Kaplan-Meier Survival Analysis
SKCM	0.022	Kaplan-Meier Survival Analysis
PRAD	0.032	Kaplan-Meier Survival Analysis
KIRP	0.012	Kaplan-Meier Survival Analysis
PAAD	0.035	Kaplan-Meier Survival Analysis
BLCA	0.0021	Kaplan-Meier Survival Analysis
KICH	0.0031	Kaplan-Meier Survival Analysis
UCEC	0.00029	Kaplan-Meier Survival Analysis
LIHC	0.014	Kaplan-Meier Survival Analysis
LGG	0.00011	Kaplan-Meier Survival Analysis
CHOL	0.026	Kaplan-Meier Survival Analysis
THCA	0.012	Kaplan-Meier Survival Analysis

Description

RBDs

RBPome

PRI

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000144161 (Gene tree)
Gene ID: 84524
Gene Symbol: ZC3H8
Alias: Fliz1|ZC3HDC8
Full Name: zinc finger CCCH-type containing 8
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 43,612 bases
Position: chr2:112,211,525-112,255,136
Accession: 30941
RBP type: canonical RBP
Summary: (Zinc Finger CCCH-Type Containing 8) is a Protein Coding gene. Among its related pathways are Tat-mediated elongation of the HIV-1 transcript and Gene Expression. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is ZC3H6.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000272570	zf-CCCH	PF00642.24	5.5e-11	1	2
ENSP00000272570	zf-CCCH	PF00642.24	5.5e-11	2	2
ENSP00000386488	zf-CCCH	PF00642.24	5.5e-11	1	2
ENSP00000386488	zf-CCCH	PF00642.24	5.5e-11	2	2
ENSP00000483976	zf-CCCH	PF00642.24	6e-11	1	2
ENSP00000483976	zf-CCCH	PF00642.24	6e-11	2	2
ENSP00000272570	zf-CCCH_2	PF14608.6	5.1e-06	1	3
ENSP00000272570	zf-CCCH_2	PF14608.6	5.1e-06	2	3
ENSP00000272570	zf-CCCH_2	PF14608.6	5.1e-06	3	3
ENSP00000386488	zf-CCCH_2	PF14608.6	5.1e-06	1	3
ENSP00000386488	zf-CCCH_2	PF14608.6	5.1e-06	2	3
ENSP00000386488	zf-CCCH_2	PF14608.6	5.1e-06	3	3
ENSP00000483976	zf-CCCH_2	PF14608.6	5.6e-06	1	3
ENSP00000483976	zf-CCCH_2	PF14608.6	5.6e-06	2	3
ENSP00000483976	zf-CCCH_2	PF14608.6	5.6e-06	3	3

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000409573	ZC3H8-202	5965	XM_017005107	ENSP00000386488	291 (aa)	XP_016860596	Q8N5P1
ENST00000466259	ZC3H8-204	565	-	-	- (aa)	-	-
ENST00000272570	ZC3H8-201	1601	-	ENSP00000272570	291 (aa)	-	Q8N5P1
ENST00000476902	ZC3H8-206	860	-	-	- (aa)	-	-
ENST00000495264	ZC3H8-207	319	-	-	- (aa)	-	-
ENST00000464305	ZC3H8-203	554	-	-	- (aa)	-	-
ENST00000615791	ZC3H8-208	1527	-	ENSP00000483976	297 (aa)	-	A0A0C4DGZ1
ENST00000474234	ZC3H8-205	847	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000144161's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000144161's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000144161	ZC3H8	81	83.333	ENSAMEG00000016207	ZC3H8	99	83.333	Ailuropoda_melanoleuca
ENSG00000144161	ZC3H8	100	90.508	ENSANAG00000022151	ZC3H8	100	90.508	Aotus_nancymaae
ENSG00000144161	ZC3H8	99	78.218	ENSBTAG00000015965	ZC3H8	99	78.218	Bos_taurus
ENSG00000144161	ZC3H8	100	90.847	ENSCJAG00000040629	ZC3H8	100	90.847	Callithrix_jacchus
ENSG00000144161	ZC3H8	99	84.539	ENSCAFG00000007155	ZC3H8	77	84.539	Canis_familiaris
ENSG00000144161	ZC3H8	99	84.539	ENSCAFG00020017540	ZC3H8	92	84.539	Canis_lupus_dingo
ENSG00000144161	ZC3H8	99	75.974	ENSCHIG00000012152	ZC3H8	99	75.974	Capra_hircus
ENSG00000144161	ZC3H8	99	85.762	ENSTSYG00000006668	ZC3H8	100	85.526	Carlito_syrichta
ENSG00000144161	ZC3H8	91	75.000	ENSCPOG00000008258	ZC3H8	100	75.000	Cavia_porcellus
ENSG00000144161	ZC3H8	100	87.458	ENSCCAG00000034286	-	100	87.458	Cebus_capucinus
ENSG00000144161	ZC3H8	100	90.847	ENSCCAG00000019771	-	100	90.847	Cebus_capucinus
ENSG00000144161	ZC3H8	100	95.254	ENSCATG00000031295	ZC3H8	100	95.254	Cercocebus_atys
ENSG00000144161	ZC3H8	100	77.049	ENSCLAG00000006848	ZC3H8	100	77.049	Chinchilla_lanigera
ENSG00000144161	ZC3H8	84	95.582	ENSCSAG00000016801	ZC3H8	98	95.582	Chlorocebus_sabaeus
ENSG00000144161	ZC3H8	91	69.485	ENSCHOG00000010391	ZC3H8	99	69.485	Choloepus_hoffmanni
ENSG00000144161	ZC3H8	100	71.717	ENSCANG00000014691	ZC3H8	100	71.717	Colobus_angolensis_palliatus
ENSG00000144161	ZC3H8	100	74.837	ENSCGRG00001018353	Zc3h8	100	74.837	Cricetulus_griseus_chok1gshd
ENSG00000144161	ZC3H8	100	74.837	ENSCGRG00000016191	Zc3h8	100	74.837	Cricetulus_griseus_crigri
ENSG00000144161	ZC3H8	100	77.049	ENSDORG00000029341	Zc3h8	100	77.049	Dipodomys_ordii
ENSG00000144161	ZC3H8	100	59.259	ENSETEG00000016560	ZC3H8	100	59.259	Echinops_telfairi
ENSG00000144161	ZC3H8	99	84.211	ENSEASG00005006490	ZC3H8	99	86.513	Equus_asinus_asinus
ENSG00000144161	ZC3H8	99	86.513	ENSECAG00000022765	ZC3H8	99	86.513	Equus_caballus
ENSG00000144161	ZC3H8	99	73.841	ENSEEUG00000006984	ZC3H8	99	73.841	Erinaceus_europaeus
ENSG00000144161	ZC3H8	99	83.660	ENSFCAG00000008088	ZC3H8	99	83.660	Felis_catus
ENSG00000144161	ZC3H8	100	77.124	ENSFDAG00000001021	ZC3H8	100	77.124	Fukomys_damarensis
ENSG00000144161	ZC3H8	100	98.969	ENSGGOG00000009004	ZC3H8	100	98.969	Gorilla_gorilla
ENSG00000144161	ZC3H8	100	75.080	ENSHGLG00000008367	ZC3H8	100	75.080	Heterocephalus_glaber_female
ENSG00000144161	ZC3H8	57	84.024	ENSHGLG00100017277	-	100	84.024	Heterocephalus_glaber_male
ENSG00000144161	ZC3H8	100	84.314	ENSSTOG00000006347	ZC3H8	100	84.314	Ictidomys_tridecemlineatus
ENSG00000144161	ZC3H8	99	80.667	ENSLAFG00000004675	ZC3H8	99	80.667	Loxodonta_africana
ENSG00000144161	ZC3H8	100	95.593	ENSMFAG00000031522	ZC3H8	100	95.593	Macaca_fascicularis
ENSG00000144161	ZC3H8	100	95.932	ENSMMUG00000044163	ZC3H8	100	95.932	Macaca_mulatta
ENSG00000144161	ZC3H8	100	95.593	ENSMNEG00000034502	ZC3H8	100	95.593	Macaca_nemestrina
ENSG00000144161	ZC3H8	100	94.915	ENSMLEG00000029980	ZC3H8	100	94.915	Mandrillus_leucophaeus
ENSG00000144161	ZC3H8	100	73.856	ENSMAUG00000012509	Zc3h8	100	73.856	Mesocricetus_auratus
ENSG00000144161	ZC3H8	100	87.908	ENSMICG00000045551	ZC3H8	100	87.908	Microcebus_murinus
ENSG00000144161	ZC3H8	100	73.770	ENSMOCG00000015035	Zc3h8	100	73.770	Microtus_ochrogaster
ENSG00000144161	ZC3H8	100	75.082	MGP_CAROLIEiJ_G0024276	Zc3h8	100	75.082	Mus_caroli
ENSG00000144161	ZC3H8	100	75.738	ENSMUSG00000027387	Zc3h8	100	75.738	Mus_musculus
ENSG00000144161	ZC3H8	100	74.754	MGP_PahariEiJ_G0025721	Zc3h8	100	74.754	Mus_pahari
ENSG00000144161	ZC3H8	100	75.082	MGP_SPRETEiJ_G0025196	Zc3h8	100	75.082	Mus_spretus
ENSG00000144161	ZC3H8	99	80.323	ENSMPUG00000009562	ZC3H8	99	80.323	Mustela_putorius_furo
ENSG00000144161	ZC3H8	90	74.101	ENSMLUG00000004890	ZC3H8	100	74.286	Myotis_lucifugus
ENSG00000144161	ZC3H8	100	74.183	ENSNGAG00000010427	Zc3h8	100	74.183	Nannospalax_galili
ENSG00000144161	ZC3H8	100	97.619	ENSNLEG00000001619	ZC3H8	100	97.619	Nomascus_leucogenys
ENSG00000144161	ZC3H8	90	73.913	ENSOPRG00000011183	ZC3H8	99	73.913	Ochotona_princeps
ENSG00000144161	ZC3H8	100	73.529	ENSODEG00000006594	ZC3H8	100	73.529	Octodon_degus
ENSG00000144161	ZC3H8	99	83.498	ENSOCUG00000011253	ZC3H8	88	83.498	Oryctolagus_cuniculus
ENSG00000144161	ZC3H8	100	79.421	ENSOGAG00000002554	ZC3H8	100	81.350	Otolemur_garnettii
ENSG00000144161	ZC3H8	99	79.868	ENSOARG00000014475	ZC3H8	99	79.868	Ovis_aries
ENSG00000144161	ZC3H8	100	99.313	ENSPPAG00000028071	ZC3H8	100	99.313	Pan_paniscus
ENSG00000144161	ZC3H8	99	83.987	ENSPPRG00000005648	ZC3H8	99	83.987	Panthera_pardus
ENSG00000144161	ZC3H8	99	83.987	ENSPTIG00000016697	ZC3H8	99	83.987	Panthera_tigris_altaica
ENSG00000144161	ZC3H8	100	99.313	ENSPTRG00000012362	ZC3H8	100	99.313	Pan_troglodytes
ENSG00000144161	ZC3H8	100	95.254	ENSPANG00000016995	ZC3H8	100	95.254	Papio_anubis
ENSG00000144161	ZC3H8	97	70.915	ENSPEMG00000011068	Zc3h8	97	70.915	Peromyscus_maniculatus_bairdii
ENSG00000144161	ZC3H8	99	98.966	ENSPPYG00000012165	ZC3H8	99	98.966	Pongo_abelii
ENSG00000144161	ZC3H8	100	58.278	ENSPCAG00000015426	ZC3H8	100	58.278	Procavia_capensis
ENSG00000144161	ZC3H8	100	87.582	ENSPCOG00000021690	ZC3H8	100	87.582	Propithecus_coquereli
ENSG00000144161	ZC3H8	100	59.532	ENSPVAG00000003510	ZC3H8	100	62.542	Pteropus_vampyrus
ENSG00000144161	ZC3H8	100	73.770	ENSRNOG00000017647	Zc3h8	100	73.770	Rattus_norvegicus
ENSG00000144161	ZC3H8	100	95.254	ENSRBIG00000027345	ZC3H8	100	95.254	Rhinopithecus_bieti
ENSG00000144161	ZC3H8	100	95.593	ENSRROG00000039459	ZC3H8	100	95.593	Rhinopithecus_roxellana
ENSG00000144161	ZC3H8	100	87.375	ENSSBOG00000028167	ZC3H8	100	87.375	Saimiri_boliviensis_boliviensis
ENSG00000144161	ZC3H8	86	72.692	ENSSARG00000012883	ZC3H8	99	72.563	Sorex_araneus
ENSG00000144161	ZC3H8	84	78.626	ENSSSCG00000008099	ZC3H8	97	79.389	Sus_scrofa
ENSG00000144161	ZC3H8	58	86.667	ENSTBEG00000015547	-	68	86.667	Tupaia_belangeri
ENSG00000144161	ZC3H8	84	77.481	ENSTTRG00000013153	ZC3H8	85	80.153	Tursiops_truncatus
ENSG00000144161	ZC3H8	99	81.908	ENSUAMG00000002411	ZC3H8	99	81.908	Ursus_americanus
ENSG00000144161	ZC3H8	99	82.895	ENSUMAG00000008665	ZC3H8	99	82.895	Ursus_maritimus
ENSG00000144161	ZC3H8	100	81.311	ENSVPAG00000005911	ZC3H8	100	82.951	Vicugna_pacos
ENSG00000144161	ZC3H8	99	84.539	ENSVVUG00000028659	ZC3H8	99	84.539	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0001162	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	21873635.	IBA	Function
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	-	IEA	Function
GO:0003700	DNA-binding transcription factor activity	21873635.	IBA	Function
GO:0003700	DNA-binding transcription factor activity	12153508.	IMP	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	23932780.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	-	ISS	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006915	apoptotic process	-	IEA	Process
GO:0008023	transcription elongation factor complex	23932780.	IDA	Component
GO:0015030	Cajal body	23932780.	IDA	Component
GO:0016604	nuclear body	-	IDA	Component
GO:0033085	negative regulation of T cell differentiation in thymus	12153508.	IMP	Process
GO:0035327	transcriptionally active chromatin	23932780.	IDA	Component
GO:0035363	histone locus body	23932780.	IDA	Component
GO:0042795	snRNA transcription by RNA polymerase II	23932780.	IMP	Process
GO:0042795	snRNA transcription by RNA polymerase II	-	TAS	Process
GO:0042796	snRNA transcription by RNA polymerase III	23932780.	IMP	Process
GO:0043029	T cell homeostasis	12153508.	IMP	Process
GO:0043565	sequence-specific DNA binding	-	ISS	Function
GO:0045892	negative regulation of transcription, DNA-templated	21873635.	IBA	Process
GO:0045892	negative regulation of transcription, DNA-templated	12077251.	IDA	Process
GO:0045892	negative regulation of transcription, DNA-templated	-	ISS	Process
GO:0045945	positive regulation of transcription by RNA polymerase III	23932780.	IMP	Process
GO:0046677	response to antibiotic	12153508.	IDA	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0070245	positive regulation of thymocyte apoptotic process	12153508.	IMP	Process

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.