EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
15704140	LAF-4 is aberrantly expressed in human breast cancer.	Int J Cancer	2005 Jul 1	To MD	-
30326937	AFF3 upregulation mediates tamoxifen resistance in breast cancers.	J Exp Clin Cancer Res	2018 Oct 16	Shi Y	doi: 10.1186/s13046-018-0928-7.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr2	99551496	Missense_Mutation	rs150108936	R1220Q	0.29
ACC	chr2	99593733	Missense_Mutation	novel	S643C	0.2
BLCA	chr2	99593548	Missense_Mutation	novel	D705H	0.17
BLCA	chr2	100006710	Silent	novel	R265R	0.38
BLCA	chr2	100006833	Frame_Shift_Del	novel	*S225Afs11**	0.4
BLCA	chr2	100006809	Silent	rs375022351	T232T	0.24
BLCA	chr2	100006629	Splice_Region	novel		0.32
BLCA	chr2	99554342	Missense_Mutation	NA	E1176D	0.05
BLCA	chr2	99593662	Missense_Mutation	NA	E667Q	0.32
BLCA	chr2	99565590	Missense_Mutation	novel	E1006K	0.17
BLCA	chr2	99593294	Missense_Mutation	NA	L789F	0.36
BLCA	chr2	99582966	Missense_Mutation	novel	M875I	0.39
BLCA	chr2	99593459	Silent	rs780306052	I734I	0.41
BLCA	chr2	99593704	Missense_Mutation	NA	R653W	0.17
BLCA	chr2	99582911	Missense_Mutation	rs781704362	E894K	0.48
BLCA	chr2	99582911	Missense_Mutation	rs781704362	E894K	0.21
BLCA	chr2	99593249	Frame_Shift_Ins	novel	*H804Qfs31**	0.23
BLCA	chr2	99554526	Missense_Mutation	NA	G1115E	0.33
BLCA	chr2	99551489	Silent	NA	S1222S	0.17
BLCA	chr2	99593458	Missense_Mutation	novel	A735T	0.1
BLCA	chr2	99593390	Silent	NA	L757L	0.24
BLCA	chr2	99593291	Silent	rs770142712	S790S	0.07
BLCA	chr2	99744105	Splice_Region	novel	P346P	0.29
BLCA	chr2	100006776	Silent	NA	Q243Q	0.73
BLCA	chr2	99554473	Nonsense_Mutation	novel	Q1133*	0.42
BLCA	chr2	99594273	Missense_Mutation	NA	S463F	0.12
BLCA	chr2	99560427	Missense_Mutation	NA	M1043I	0.18
BLCA	chr2	99582833	Missense_Mutation	NA	D920Y	0.2
BLCA	chr2	99594095	Missense_Mutation	NA	E522D	0.05
BLCA	chr2	99727117	Missense_Mutation	NA	A351T	0.41
BRCA	chr2	100006793	Missense_Mutation	novel	M238V	0.07
BRCA	chr2	99554483	Silent	novel	S1129S	0.27
BRCA	chr2	99565570	Frame_Shift_Del	novel	*I1012Mfs25**	0.05
BRCA	chr2	99593308	Missense_Mutation	NA	E785Q	0.33
BRCA	chr2	99593369	Missense_Mutation	NA	R764S	0.14
BRCA	chr2	100007564	Intron	novel		0.08
BRCA	chr2	100008827	Missense_Mutation	NA	F53L	0.15
BRCA	chr2	100006548	Intron	novel		0.24
BRCA	chr2	100006660	Missense_Mutation	NA	S282C	0.5
BRCA	chr2	100007432	Missense_Mutation	rs780730596	R68Q	0.38
BRCA	chr2	100007260	Silent	NA	I125I	0.18
BRCA	chr2	99582828	Missense_Mutation	NA	S921R	0.15
BRCA	chr2	99560406	Silent	NA	G1050G	0.07
BRCA	chr2	99568849	Splice_Region	novel		0.2
BRCA	chr2	99578401	Silent	rs751111814	P948P	0.28
BRCA	chr2	100006967	Missense_Mutation	NA	Q180E	0.14
BRCA	chr2	100007579	Intron	novel		0.24
BRCA	chr2	99594220	Missense_Mutation	NA	P481T	0.52
BRCA	chr2	99554439	Missense_Mutation	NA	P1144L	0.45
BRCA	chr2	99649629	Missense_Mutation	novel	D394V	0.25
BRCA	chr2	99594095	Silent	NA	E522E	0.29
CESC	chr2	99568914	Missense_Mutation	NA	P974S	0.27
CESC	chr2	99593367	Missense_Mutation	NA	S765Y	0.16
CESC	chr2	99593519	Silent	NA	N714N	0.36
CESC	chr2	99593605	Missense_Mutation	novel	E686Q	0.32
CESC	chr2	99547419	3'UTR	novel		0.34
CESC	chr2	100007307	Missense_Mutation	NA	E110K	0.35	AF-4
CESC	chr2	99582808	Missense_Mutation	novel	G928E	0.2
CESC	chr2	99568911	Missense_Mutation	NA	R975C	0.29
CESC	chr2	99672558	Missense_Mutation	NA	D375N	0.46
CESC	chr2	99601476	Missense_Mutation	NA	E444K	0.15
CESC	chr2	99565534	In_Frame_Del	novel	E1024del	0.05
CESC	chr2	99593656	Nonsense_Mutation	novel	E669*	0.5
CESC	chr2	99837488	Nonsense_Mutation	novel	E304*	0.1
CESC	chr2	99582931	Missense_Mutation	novel	S887C	0.22
CESC	chr2	99727104	Missense_Mutation	NA	S355N	0.52
CESC	chr2	100006800	Silent	NA	V235V	0.44
CESC	chr2	99554482	Missense_Mutation	rs143764541	V1130M	0.33
CESC	chr2	100105418	5'Flank	NA		0.27
CESC	chr2	99601476	Missense_Mutation	NA	E444Q	0.43
CESC	chr2	100006732	Missense_Mutation	novel	S258N	0.35
CESC	chr2	100106129	5'Flank	NA		0.1
CHOL	chr2	100006835	Missense_Mutation	novel	P224T	0.17
COAD	chr2	99593839	Missense_Mutation	novel	P608S	0.67
COAD	chr2	99582799	Missense_Mutation	rs373018231	T931M	0.42
COAD	chr2	99593646	Missense_Mutation	NA	S672F	0.46
COAD	chr2	100007440	Silent	NA	L65L	0.38
COAD	chr2	99565577	Nonsense_Mutation	NA	S1010*	0.44
COAD	chr2	99554696	Missense_Mutation	rs542558981	G1108R	0.1
COAD	chr2	99587269	Missense_Mutation	rs369487993	E826K	0.32
COAD	chr2	99578396	Missense_Mutation	rs368944733	T950M	0.25
COAD	chr2	99554717	Missense_Mutation	rs771583669	A1101T	0.2
COAD	chr2	100105561	5'Flank	novel		0.2
COAD	chr2	100007264	Missense_Mutation	novel	S124Y	0.18	AF-4
COAD	chr2	100008930	Missense_Mutation	NA	V19A	0.38
COAD	chr2	99554456	Silent	rs780887781	N1138N	0.33
COAD	chr2	99582968	Frame_Shift_Del	NA	*M875Cfs22**	0.25
COAD	chr2	99578406	Missense_Mutation	rs756186388	R947W	0.34
COAD	chr2	100006564	Intron	novel		0.5
COAD	chr2	99565619	Missense_Mutation	novel	E996G	0.28
COAD	chr2	99568868	Missense_Mutation	novel	H989R	0.36
COAD	chr2	99593737	Missense_Mutation	rs780233607	R642C	0.44
COAD	chr2	100008903	Missense_Mutation	rs145368049	R28Q	0.36
COAD	chr2	100105501	5'Flank	novel		0.22
COAD	chr2	99593519	Silent	NA	N714N	0.38
COAD	chr2	99593816	Frame_Shift_Del	novel	*T616Rfs30**	0.17
COAD	chr2	100105865	5'Flank	NA		0.4
COAD	chr2	99593846	Silent	NA	P605P	0.83
COAD	chr2	99551416	3'UTR	novel		0.28
COAD	chr2	99554336	Silent	rs779038332	A1178A	0.47
COAD	chr2	99568906	Silent	novel	S976S	0.39
COAD	chr2	99752263	Silent	novel	A320A	0.11
COAD	chr2	100105991	5'Flank	novel		0.26
COAD	chr2	99582994	Missense_Mutation	NA	A866V	0.25
COAD	chr2	100006949	Missense_Mutation	NA	V186L	0.2
COAD	chr2	100007278	Missense_Mutation	novel	Q119H	0.24	AF-4
COAD	chr2	100106012	5'Flank	novel		0.26
COAD	chr2	99578336	Missense_Mutation	NA	F970S	0.26
COAD	chr2	99593737	Missense_Mutation	rs780233607	R642C	0.28
COAD	chr2	99565576	Silent	rs747852637	S1010S	0.27
COAD	chr2	99565577	Nonsense_Mutation	NA	S1010*	0.3
COAD	chr2	100006750	Missense_Mutation	NA	K252T	0.22
COAD	chr2	99594165	Missense_Mutation	NA	P499L	0.39
COAD	chr2	99601452	Frame_Shift_Del	NA	*H452Tfs21**	0.14
COAD	chr2	99560417	Missense_Mutation	novel	T1047P	0.26
COAD	chr2	100007358	Missense_Mutation	rs753942953	V93I	0.23
ESCA	chr2	100006902	Silent	NA	A201A	0.27
ESCA	chr2	100006785	Silent	novel	G240G	0.19
ESCA	chr2	99649643	Silent	novel	L389L	0.14
ESCA	chr2	99593822	Silent	novel	A613A	0.27
ESCA	chr2	99587214	Missense_Mutation	novel	R844T	0.28
ESCA	chr2	99582845	Missense_Mutation	novel	K916E	0.34
ESCA	chr2	100105551	5'Flank	novel		0.34
ESCA	chr2	99547391	3'UTR	novel		0.96
ESCA	chr2	99593685	Missense_Mutation	novel	V659A	0.3
ESCA	chr2	100007251	Silent	novel	T128T	0.22
ESCA	chr2	100007200	Silent	novel	T145T	0.44
GBM	chr2	99593392	Missense_Mutation	NA	L757V	0.38
GBM	chr2	99565495	Silent	novel	E1037E	0.05
GBM	chr2	99565577	Missense_Mutation	NA	S1010L	0.59
GBM	chr2	99582962	Missense_Mutation	rs190577667	R877W	0.13
GBM	chr2	99587208	In_Frame_Del	novel	A846del	0.04
HNSC	chr2	99582889	Missense_Mutation	novel	R901L	0.4
HNSC	chr2	99554693	Frame_Shift_Del	NA	*A1109Pfs155**	0.11
HNSC	chr2	99649643	Silent	novel	L389L	0.08
HNSC	chr2	99594286	Nonsense_Mutation	novel	E459*	0.15
HNSC	chr2	99587231	Missense_Mutation	novel	E838D	0.19
HNSC	chr2	99587247	Missense_Mutation	novel	K833R	0.32
HNSC	chr2	99593722	Missense_Mutation	novel	C647S	0.41
HNSC	chr2	99593744	Silent	novel	K639K	0.16
HNSC	chr2	100006671	Silent	novel	K278K	0.47
HNSC	chr2	99593803	Missense_Mutation	rs756174447	V620I	0.12
HNSC	chr2	100008910	Missense_Mutation	novel	A26T	0.2
HNSC	chr2	99593258	Silent	novel	P801P	0.36
HNSC	chr2	100007320	Silent	novel	V105V	0.12
HNSC	chr2	99587264	Silent	NA	D827D	0.46
HNSC	chr2	99568878	Nonsense_Mutation	NA	R986*	0.15
HNSC	chr2	99582833	Missense_Mutation	rs202104245	D920N	0.21
HNSC	chr2	99752221	Missense_Mutation	novel	K334N	0.31
HNSC	chr2	100007269	Silent	novel	P122P	0.41
HNSC	chr2	99593421	Missense_Mutation	novel	P747L	0.41
HNSC	chr2	99593423	Silent	novel	V746V	0.41
HNSC	chr2	99593861	Silent	novel	A600A	0.08
HNSC	chr2	99593693	Missense_Mutation	novel	S656R	0.29
HNSC	chr2	99593519	Frame_Shift_Del	novel	*N714Gfs9**	0.5
HNSC	chr2	100006998	Missense_Mutation	novel	R169S	0.23
HNSC	chr2	100008868	Missense_Mutation	novel	Q40K	0.38
HNSC	chr2	100007533	Intron	novel		0.6
HNSC	chr2	100007394	Missense_Mutation	novel	D81H	0.16
HNSC	chr2	99560374	Missense_Mutation	novel	A1061D	0.23
KICH	chr2	99551488	Missense_Mutation	rs138104794	A1223T	0.64
KICH	chr2	99593704	Missense_Mutation	NA	R653W	0.88
KIRC	chr2	99594243	Frame_Shift_Del	novel	*N473Tfs11**	0.27
KIRC	chr2	99587164	Missense_Mutation	novel	N861D	0.23
KIRC	chr2	99582810	Silent	rs148546971	G927G	0.07
KIRC	chr2	100008840	Missense_Mutation	NA	S49T	0.11
KIRC	chr2	99582898	Missense_Mutation	NA	S898Y	0.32
KIRC	chr2	100006657	Frame_Shift_Del	novel	*K283Sfs23**	0.44
KIRP	chr2	99649642	Missense_Mutation	novel	R390G	0.24
KIRP	chr2	100006788	Silent	rs138844530	D239D	0.44
LIHC	chr2	99594178	Missense_Mutation	NA	Q495K	0.29
LIHC	chr2	99578395	Silent	rs762823547	T950T	0.33
LIHC	chr2	99672541	Missense_Mutation	novel	E380D	0.12
LUAD	chr2	100007181	Missense_Mutation	novel	G152W	0.24	AF-4
LUAD	chr2	99593576	Frame_Shift_Del	novel	*V696Wfs13**	0.12
LUAD	chr2	99593763	Missense_Mutation	novel	N633S	0.41
LUAD	chr2	100006708	Missense_Mutation	NA	G266V	0.5
LUAD	chr2	99594060	Missense_Mutation	NA	R534K	0.4
LUAD	chr2	99554686	Missense_Mutation	novel	G1111E	0.25
LUAD	chr2	100011535	Intron	novel		0.19
LUAD	chr2	99565557	Missense_Mutation	novel	A1017S	0.18
LUAD	chr2	99593789	Silent	novel	P624P	0.31
LUAD	chr2	99565501	Silent	NA	T1035T	0.05
LUAD	chr2	100007224	Silent	novel	P137P	0.21
LUAD	chr2	100007472	Intron	novel		0.18
LUAD	chr2	99593777	Silent	NA	R628R	0.3
LUAD	chr2	100007379	Nonsense_Mutation	NA	R86*	0.26
LUAD	chr2	99593719	Missense_Mutation	NA	E648K	0.13
LUAD	chr2	99837488	Missense_Mutation	novel	E304Q	0.23
LUSC	chr2	100007215	Silent	novel	Q140Q	0.05
LUSC	chr2	99578405	Missense_Mutation	novel	R947L	0.24
LUSC	chr2	99582942	Silent	novel	L883L	0.25
LUSC	chr2	99582911	Missense_Mutation	rs781704362	E894K	0.19
LUSC	chr2	99593408	Silent	rs752241159	N751N	0.21
LUSC	chr2	99649660	Missense_Mutation	novel	A384S	0.14
LUSC	chr2	99727076	Splice_Site	NA	X364_splice	0.23
LUSC	chr2	100007463	Splice_Region	novel		0.1
LUSC	chr2	99565569	Missense_Mutation	rs768278281	E1013K	0.4
LUSC	chr2	99672591	Splice_Site	novel	X364_splice	0.16
LUSC	chr2	100006512	Intron	novel		0.19
LUSC	chr2	100011550	Intron	novel		0.24
LUSC	chr2	99582908	Missense_Mutation	novel	D895Y	0.39
LUSC	chr2	100006770	Silent	novel	P245P	0.37
LUSC	chr2	99752281	Silent	novel	P314P	0.31
LUSC	chr2	99593277	Missense_Mutation	NA	K795R	0.39
LUSC	chr2	99587212	Missense_Mutation	NA	L845V	0.19
LUSC	chr2	99554444	Silent	NA	L1142L	0.65
LUSC	chr2	100007338	Silent	NA	G99G	0.4
LUSC	chr2	99560429	Missense_Mutation	novel	M1043L	0.18
LUSC	chr2	99593565	Missense_Mutation	rs775211684	S699F	0.11
LUSC	chr2	99593682	Missense_Mutation	novel	P660H	0.38
LUSC	chr2	100006660	Missense_Mutation	NA	S282C	0.16
LUSC	chr2	100007431	Silent	NA	R68R	0.35
LUSC	chr2	99551513	Silent	novel	Q1214Q	0.08
LUSC	chr2	99578371	Silent	rs372813543	N958N	0.22
LUSC	chr2	100007576	Intron	novel		0.3
LUSC	chr2	99594149	Silent	rs146485516	V504V	0.11
LUSC	chr2	99582998	Missense_Mutation	novel	V865L	0.28
LUSC	chr2	100007278	Missense_Mutation	novel	Q119H	0.18	AF-4
LUSC	chr2	100007352	Missense_Mutation	novel	V95F	0.17
LUSC	chr2	99593199	Missense_Mutation	novel	R821L	0.62
LUSC	chr2	99551438	3'UTR	novel		0.07
LUSC	chr2	99551539	Missense_Mutation	rs771877689	E1206Q	0.05
LUSC	chr2	100007307	Nonsense_Mutation	novel	E110*	0.23	AF-4
LUSC	chr2	99593741	Missense_Mutation	NA	E640D	0.14
OV	chr2	99558886	Missense_Mutation	NA	D1092H	0.44
OV	chr2	100006480	Intron	novel		0.09
OV	chr2	100008928	Missense_Mutation	NA	Y20H	0.27
OV	chr2	100008910	Missense_Mutation	novel	A26T	0.06
OV	chr2	100006998	Missense_Mutation	novel	R169S	0.06
OV	chr2	99554403	Frame_Shift_Ins	novel	*Q1156Lfs97**	0.18
OV	chr2	100007481	Intron	novel		0.41
OV	chr2	100006860	Silent	novel	N215N	0.52
OV	chr2	99558884	Silent	NA	D1092D	0.11
OV	chr2	99837510	Silent	novel	G296G	0.08
OV	chr2	100007193	Missense_Mutation	novel	W148R	0.05	AF-4
OV	chr2	99551445	3'UTR	novel		0.31
OV	chr2	99593446	Missense_Mutation	novel	E739K	0.06
PAAD	chr2	99593736	Missense_Mutation	novel	R642H	0.44
PAAD	chr2	99593795	Silent	rs764569019	P622P	0.06
PAAD	chr2	99593365	Missense_Mutation	novel	L766I	0.16
PAAD	chr2	99593568	Missense_Mutation	novel	A698V	0.26
PAAD	chr2	99593846	Silent	NA	P605P	0.29
PAAD	chr2	99649641	Missense_Mutation	rs201587401	R390H	0.17
PAAD	chr2	99837525	Splice_Site	novel	X292_splice	0.07
PAAD	chr2	100006483	Intron	novel		0.19
PAAD	chr2	100007346	Missense_Mutation	novel	K97E	0.25	AF-4
PAAD	chr2	100006967	Missense_Mutation	novel	Q180K	0.05
PRAD	chr2	99582841	Missense_Mutation	rs772627894	P917R	0.05
PRAD	chr2	99593530	Missense_Mutation	NA	A711S	0.1
PRAD	chr2	99554456	Silent	rs780887781	N1138N	0.12
PRAD	chr2	100007431	Silent	novel	R68R	0.35
PRAD	chr2	100007572	Intron	novel		0.13
PRAD	chr2	99587278	Missense_Mutation	NA	C823R	0.38
PRAD	chr2	99565517	Missense_Mutation	rs530073150	T1030M	0.41
PRAD	chr2	99593737	Missense_Mutation	rs780233607	R642C	0.29
PRAD	chr2	100006885	Missense_Mutation	novel	S207N	0.41
READ	chr2	99593652	Missense_Mutation	novel	S670L	0.31
READ	chr2	99593706	Missense_Mutation	rs764752937	T652M	0.62
READ	chr2	99551585	Silent	NA	N1190N	0.51
READ	chr2	99582831	Missense_Mutation	novel	D920E	0.1
READ	chr2	99593749	Missense_Mutation	NA	R638C	0.24
READ	chr2	99727085	Silent	rs764004964	S361S	0.43
READ	chr2	100006746	Silent	rs371774868	S253S	0.4
READ	chr2	99558959	Silent	NA	C1067C	0.26
READ	chr2	100105535	5'Flank	novel		0.17
SARC	chr2	99593464	Missense_Mutation	novel	D733H	0.26
SARC	chr2	99593519	Silent	NA	N714N	0.3
SARC	chr2	100105523	5'Flank	novel		0.06
SKCM	chr2	99554320	Missense_Mutation	NA	E1184K	0.39
SKCM	chr2	100007310	Missense_Mutation	rs556588114	D109N	0.31	AF-4
SKCM	chr2	99593817	Missense_Mutation	NA	G615E	0.76
SKCM	chr2	99554442	Missense_Mutation	NA	S1143F	0.41
SKCM	chr2	100007680	Intron	novel		0.5
SKCM	chr2	99565516	Silent	rs202074625	T1030T	0.41
SKCM	chr2	100008891	Missense_Mutation	rs751422700	R32Q	0.3
SKCM	chr2	99593624	Silent	rs746119773	S679S	0.2
SKCM	chr2	100006798	Missense_Mutation	NA	R236K	0.29
SKCM	chr2	99593834	Silent	NA	A609A	0.13
SKCM	chr2	100007224	Silent	NA	P137P	0.24
SKCM	chr2	99594008	Silent	rs763118251	P551P	0.32
SKCM	chr2	99551520	Missense_Mutation	NA	S1212F	0.15
SKCM	chr2	99554440	Missense_Mutation	NA	P1144S	0.31
SKCM	chr2	99593800	Missense_Mutation	novel	P621S	0.23
SKCM	chr2	99593801	Silent	rs750564737	V620V	0.23
SKCM	chr2	100007584	Intron	novel		0.42
SKCM	chr2	99594130	Missense_Mutation	NA	P511S	0.71
SKCM	chr2	99593846	Silent	NA	P605P	0.28
SKCM	chr2	99554459	Silent	NA	S1137S	0.4
SKCM	chr2	99593289	Missense_Mutation	novel	A791G	0.23
SKCM	chr2	100007251	Silent	novel	T128T	0.38
SKCM	chr2	99582858	Silent	NA	A911A	0.08
SKCM	chr2	99582974	Missense_Mutation	NA	E873K	0.64
SKCM	chr2	99672549	Missense_Mutation	novel	E378K	0.04
SKCM	chr2	99582798	Splice_Region	NA	T931T	0.42
SKCM	chr2	99551438	3'UTR	novel		0.31
SKCM	chr2	99593687	Silent	NA	I658I	0.27
SKCM	chr2	100006818	Silent	NA	Q229Q	0.34
SKCM	chr2	99554505	Missense_Mutation	NA	P1122L	0.26
SKCM	chr2	99554718	Silent	rs781757534	A1100A	0.33
SKCM	chr2	99593675	Silent	NA	S662S	0.4
SKCM	chr2	99601467	Missense_Mutation	NA	G447C	0.68
SKCM	chr2	100007329	Missense_Mutation	NA	Q102H	0.53	AF-4
SKCM	chr2	100006928	Missense_Mutation	NA	L193F	0.3
SKCM	chr2	99593413	Missense_Mutation	novel	R750W	0.39
SKCM	chr2	99568900	Missense_Mutation	NA	D978E	0.22
SKCM	chr2	99593459	Silent	rs780306052	I734I	0.41
SKCM	chr2	99568902	Missense_Mutation	rs770126629	D978N	0.44
SKCM	chr2	99551519	Silent	novel	S1212S	0.42
SKCM	chr2	99551520	Missense_Mutation	NA	S1212F	0.42
SKCM	chr2	99593974	Missense_Mutation	NA	P563S	0.41
SKCM	chr2	99582945	Silent	NA	P882P	0.31
SKCM	chr2	100007260	Silent	NA	I125I	0.29
SKCM	chr2	99565570	Silent	rs773934210	I1012I	0.23
SKCM	chr2	99593271	Missense_Mutation	NA	S797F	0.22
SKCM	chr2	99558954	Missense_Mutation	NA	A1069V	0.49
SKCM	chr2	99594009	Missense_Mutation	NA	P551L	0.27
SKCM	chr2	100006490	Intron	novel		0.27
SKCM	chr2	100007185	Silent	NA	K150K	0.07
SKCM	chr2	100011513	Intron	NA		0.08
SKCM	chr2	99593411	Silent	NA	R750R	0.24
SKCM	chr2	99837479	Missense_Mutation	rs371493408	R307W	0.29
SKCM	chr2	99752235	Missense_Mutation	NA	P330S	0.41
SKCM	chr2	99593801	Silent	rs750564737	V620V	0.38
STAD	chr2	99593830	Missense_Mutation	rs770557623	A611T	0.33
STAD	chr2	99587264	Silent	NA	D827D	0.09
STAD	chr2	99601451	Frame_Shift_Ins	rs759949420	*H452Pfs8**	0.32
STAD	chr2	99649642	Missense_Mutation	rs762261479	R390C	0.46
STAD	chr2	100008904	Missense_Mutation	rs780991519	R28W	0.17
STAD	chr2	99551489	Silent	NA	S1222S	0.32
STAD	chr2	99554354	Silent	rs757906287	Y1172Y	0.24
STAD	chr2	99672585	Silent	rs755545087	L366L	0.19
STAD	chr2	99594090	Missense_Mutation	novel	K524R	0.22
STAD	chr2	99568878	Missense_Mutation	NA	R986G	0.07
STAD	chr2	100007387	Frame_Shift_Del	novel	L83*	0.54
STAD	chr2	100007000	Missense_Mutation	NA	R169G	0.31
STAD	chr2	99554438	Silent	rs200904404	P1144P	0.18
STAD	chr2	99582862	Nonsense_Mutation	novel	S910*	0.14
STAD	chr2	99565526	Missense_Mutation	NA	S1027Y	0.09
STAD	chr2	99593437	Missense_Mutation	NA	F742V	0.32
STAD	chr2	99554386	Missense_Mutation	rs776241053	V1162I	0.42
STAD	chr2	99554413	Missense_Mutation	novel	R1153C	0.23
STAD	chr2	100006782	Silent	NA	Q241Q	0.17
STAD	chr2	100007453	Missense_Mutation	NA	K61M	0.08
STAD	chr2	99752268	Nonsense_Mutation	NA	Q319*	0.48
STAD	chr2	99601449	Missense_Mutation	NA	F453V	0.37
STAD	chr2	99565517	Missense_Mutation	rs530073150	T1030M	0.08
STAD	chr2	99582844	Frame_Shift_Del	novel	*K916Sfs72**	0.1
STAD	chr2	99593938	Missense_Mutation	novel	A575S	0.5
STAD	chr2	99594006	Missense_Mutation	NA	A552V	0.1
STAD	chr2	100006811	Missense_Mutation	novel	T232A	0.35
STAD	chr2	100006540	Intron	novel		0.26
STAD	chr2	99558966	Missense_Mutation	NA	Y1065C	0.37
STAD	chr2	100007003	Missense_Mutation	NA	L168F	0.52
THCA	chr2	100007164	Silent	rs781371392	D157D	0.37
THYM	chr2	100006570	Intron	novel		0.15
UCEC	chr2	99593686	Missense_Mutation	NA	V659I	0.42
UCEC	chr2	99593995	Missense_Mutation	NA	V556M	0.18
UCEC	chr2	99601476	Missense_Mutation	NA	E444K	0.44
UCEC	chr2	100007589	Intron	novel		0.43
UCEC	chr2	99550939	3'UTR	novel		0.49
UCEC	chr2	99578402	Missense_Mutation	novel	P948L	0.36
UCEC	chr2	99649623	Splice_Region	novel		0.34
UCEC	chr2	100007440	Silent	NA	L65L	0.44
UCEC	chr2	99558970	Splice_Site	novel	X1064_splice	0.33
UCEC	chr2	100105879	5'Flank	rs777671014		0.24
UCEC	chr2	99594098	In_Frame_Del	rs762540363	K521del	0.42
UCEC	chr2	100007505	Intron	novel		0.09
UCEC	chr2	99578402	Missense_Mutation	novel	P948L	0.4
UCEC	chr2	99601451	Frame_Shift_Ins	rs759949420	*H452Pfs8**	0.4
UCEC	chr2	99594127	Missense_Mutation	rs763782134	D512N	0.46
UCEC	chr2	99551080	3'UTR	novel		0.25
UCEC	chr2	99565557	Missense_Mutation	novel	A1017T	0.06
UCEC	chr2	100007394	Missense_Mutation	novel	D81Y	0.43
UCEC	chr2	99593645	Silent	novel	S672S	0.18
UCEC	chr2	100007194	Silent	novel	G147G	0.25
UCEC	chr2	99568876	Silent	novel	R986R	0.36
UCEC	chr2	99554397	Missense_Mutation	NA	A1158V	0.1
UCEC	chr2	99582958	Missense_Mutation	rs557360368	S878L	0.19
UCEC	chr2	99727106	Missense_Mutation	novel	E354D	0.1
UCEC	chr2	100006731	Silent	rs370383487	S258S	0.24
UCEC	chr2	100007566	Intron	novel		0.16
UCEC	chr2	99649641	Frame_Shift_Ins	novel	*R390Qfs5**	0.36
UCEC	chr2	100006785	Silent	novel	G240G	0.34
UCEC	chr2	99578395	Silent	rs762823547	T950T	0.15
UCEC	chr2	100007589	Intron	novel		0.37
UCEC	chr2	100008915	Missense_Mutation	novel	R24I	0.44
UCEC	chr2	99551394	3'UTR	novel		0.26
UCEC	chr2	99593630	Silent	NA	S677S	0.43
UCEC	chr2	99547411	3'UTR	novel		0.38
UCEC	chr2	99551338	3'UTR	novel		0.29
UCEC	chr2	100007386	Frame_Shift_Ins	novel	*L83Ffs3**	0.52
UCEC	chr2	99547410	3'UTR	novel		0.07
UCEC	chr2	99547483	3'UTR	novel		0.31
UCEC	chr2	99601452	Frame_Shift_Del	NA	*H452Tfs21**	0.4
UCEC	chr2	100105849	5'Flank	novel		0.37
UCEC	chr2	99578335	Silent	rs142157056	F970F	0.53
UCEC	chr2	99554717	Missense_Mutation	rs771583669	A1101T	0.56
UCEC	chr2	99578328	Missense_Mutation	rs572833239	M973V	0.5
UCEC	chr2	100106004	5'Flank	novel		0.52
UCEC	chr2	100007312	Missense_Mutation	NA	I108T	0.3	AF-4
UCEC	chr2	99582940	Missense_Mutation	novel	S884Y	0.38
UCEC	chr2	99593652	Missense_Mutation	novel	S670L	0.38
UCEC	chr2	100006747	Missense_Mutation	novel	S253L	0.5
UCEC	chr2	100105964	5'Flank	novel		0.49
UCEC	chr2	99582962	Missense_Mutation	rs190577667	R877W	0.31
UCEC	chr2	100006706	Missense_Mutation	NA	V267I	0.21
UCEC	chr2	99565615	Missense_Mutation	novel	K997N	0.25
UCEC	chr2	99578335	Silent	rs142157056	F970F	0.33
UCEC	chr2	99727085	Silent	rs764004964	S361S	0.28
UCEC	chr2	100006612	Intron	novel		0.38
UCEC	chr2	99547829	3'UTR	novel		0.22
UCEC	chr2	99548147	3'UTR	novel		0.37
UCEC	chr2	99550879	3'UTR	novel		0.52
UCEC	chr2	99593575	Missense_Mutation	novel	V696M	0.26
UCEC	chr2	99593761	Missense_Mutation	novel	R634G	0.4
UCEC	chr2	100105967	5'Flank	novel		0.17
UCEC	chr2	99601451	Frame_Shift_Ins	rs759949420	*H452Pfs8**	0.33
UCEC	chr2	99649642	Missense_Mutation	rs762261479	R390C	0.42
UCEC	chr2	99578331	Missense_Mutation	novel	D972Y	0.21
UCEC	chr2	99593709	Missense_Mutation	NA	R651H	0.4
UCEC	chr2	99582858	Silent	novel	A911A	0.36
UCEC	chr2	99752269	Silent	novel	I318I	0.5
UCEC	chr2	99547772	3'UTR	novel		0.26
UCEC	chr2	99593513	Silent	novel	G716G	0.37
UCEC	chr2	99593680	Missense_Mutation	novel	K661E	0.4
UCEC	chr2	100006897	Missense_Mutation	novel	A203V	0.28
UCEC	chr2	100105902	5'Flank	novel		0.3
UCEC	chr2	100006661	Missense_Mutation	novel	S282P	0.16
UCEC	chr2	99593802	Missense_Mutation	novel	V620A	0.45
UCEC	chr2	100007333	Missense_Mutation	novel	P101H	0.5	AF-4
UCEC	chr2	100007589	Intron	novel		0.55
UCEC	chr2	100006540	Intron	novel		0.36
UCEC	chr2	100007589	Intron	novel		0.44
UCEC	chr2	99593616	Missense_Mutation	NA	E682G	0.56
UCEC	chr2	99547505	3'UTR	novel		0.22
UCEC	chr2	99547811	3'UTR	novel		0.22
UCEC	chr2	99593458	Missense_Mutation	novel	A735T	0.24
UCEC	chr2	99727116	Missense_Mutation	rs755648740	A351V	0.33
UCEC	chr2	99551506	Missense_Mutation	NA	H1217Y	0.33
UCEC	chr2	99554449	Missense_Mutation	NA	A1141T	0.12
UCEC	chr2	99554455	Missense_Mutation	rs756690263	A1139T	0.45
UCEC	chr2	99837478	Missense_Mutation	rs201088038	R307Q	0.09
UCEC	chr2	99594060	Missense_Mutation	novel	R534T	0.38
UCEC	chr2	99558922	Frame_Shift_Del	novel	*R1080Gfs5**	0.43
UCEC	chr2	99565570	Silent	rs773934210	I1012I	0.24
UCEC	chr2	99593579	Missense_Mutation	novel	Q694H	0.1
UCEC	chr2	99593494	Missense_Mutation	novel	V723I	0.11
UCEC	chr2	100007311	Silent	rs141695864	I108I	0.51
UCEC	chr2	99582962	Missense_Mutation	rs190577667	R877W	0.26
UCEC	chr2	100007378	Missense_Mutation	NA	R86K	0.21
UCEC	chr2	100006625	Splice_Region	novel		0.13
UCEC	chr2	100007470	Intron	novel		0.35
UCEC	chr2	99547984	3'UTR	novel		0.04
UCEC	chr2	99551573	Silent	rs144420168	L1194L	0.22
UCEC	chr2	99554510	Missense_Mutation	novel	M1120I	0.27
UCEC	chr2	99558914	Silent	novel	H1082H	0.46
UCEC	chr2	99582810	Silent	rs148546971	G927G	0.42
UCEC	chr2	99593492	Silent	novel	V723V	0.14
UCEC	chr2	99593595	Missense_Mutation	novel	P689L	0.2
UCEC	chr2	100006807	Missense_Mutation	novel	A233V	0.33
UCEC	chr2	99547888	3'UTR	novel		0.35
UCEC	chr2	99582962	Missense_Mutation	rs190577667	R877W	0.28
UCEC	chr2	99593529	Missense_Mutation	novel	A711V	0.5
UCEC	chr2	100006484	Intron	novel		0.45
UCEC	chr2	99551562	Missense_Mutation	NA	P1198Q	0.18
UCEC	chr2	99594058	Missense_Mutation	novel	T535S	0.3
UCEC	chr2	100006539	Intron	NA		0.5
UCEC	chr2	99547776	3'UTR	novel		0.48
UCEC	chr2	99558887	Silent	rs771851589	I1091I	0.41
UCEC	chr2	99587264	Silent	NA	D827D	0.47
UCEC	chr2	100105861	5'Flank	novel		0.35
UCEC	chr2	99593252	Silent	novel	S803S	0.35
UCS	chr2	99649637	Silent	novel	A391A	0.22
UCS	chr2	99649639	Missense_Mutation	rs546235334	A391T	0.2
UCS	chr2	99578335	Silent	rs142157056	F970F	0.33
UCS	chr2	99582962	Missense_Mutation	rs190577667	R877W	0.36
UCS	chr2	99594127	Missense_Mutation	rs763782134	D512N	0.34

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
PAAD	DEL	0.0326	0.2014

Survival Analysis

Cancer	P-value	Q-value
THYM	0.016	Kaplan-Meier Survival Analysis
KIRC	0.0001	Kaplan-Meier Survival Analysis
STAD	0.013	Kaplan-Meier Survival Analysis
ACC	0.0041	Kaplan-Meier Survival Analysis
HNSC	0.00011	Kaplan-Meier Survival Analysis
SKCM	0.0029	Kaplan-Meier Survival Analysis
LUSC	0.018	Kaplan-Meier Survival Analysis
BRCA	0.031	Kaplan-Meier Survival Analysis
PAAD	0.0029	Kaplan-Meier Survival Analysis
BLCA	0.05	Kaplan-Meier Survival Analysis
CESC	0.041	Kaplan-Meier Survival Analysis
UCEC	0.015	Kaplan-Meier Survival Analysis
LIHC	0.0065	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.0068	Kaplan-Meier Survival Analysis
UVM	0.0052	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000144218 (Gene tree)
Gene ID: 3899
Gene Symbol: AFF3
Alias: MLLT2-like|LAF4
Full Name: AF4/FMR2 family member 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 597,321 bases
Position: chr2:99,545,419-100,142,739
Accession: 6473
RBP type: canonical RBP
Summary: This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000317421	AF-4	PF05110.13	0	1	2
ENSP00000317421	AF-4	PF05110.13	0	2	2
ENSP00000387207	AF-4	PF05110.13	0	1	2
ENSP00000387207	AF-4	PF05110.13	0	2	2
ENSP00000386834	AF-4	PF05110.13	0	1	2
ENSP00000386834	AF-4	PF05110.13	0	2	2
ENSP00000416685	AF-4	PF05110.13	1.2e-88	1	1
ENSP00000406484	AF-4	PF05110.13	1.5e-46	1	1
ENSP00000396582	AF-4	PF05110.13	1.8e-46	1	1
ENSP00000399795	AF-4	PF05110.13	1.4e-44	1	1
ENSP00000411383	AF-4	PF05110.13	8.5e-43	1	1
ENSP00000395068	AF-4	PF05110.13	9.8e-40	1	1
ENSP00000393732	AF-4	PF05110.13	7.3e-29	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000409236	AFF3-202	9849	XM_005263943	ENSP00000387207	1226 (aa)	XP_005264000	P51826
ENST00000430789	AFF3-209	730	-	ENSP00000414099	179 (aa)	-	H7C3W3
ENST00000441400	AFF3-212	543	-	ENSP00000399795	128 (aa)	-	C9JZ66
ENST00000423966	AFF3-206	702	-	ENSP00000396582	155 (aa)	-	C9JC67
ENST00000409579	AFF3-203	4342	XM_011511169	ENSP00000386834	1251 (aa)	XP_011509471	P51826
ENST00000415384	AFF3-204	574	-	ENSP00000407448	183 (aa)	-	C9JUY1
ENST00000445815	AFF3-213	555	-	ENSP00000416685	185 (aa)	-	H7C4C2
ENST00000483600	AFF3-214	852	-	-	- (aa)	-	-
ENST00000317233	AFF3-201	8135	XM_011511175	ENSP00000317421	1226 (aa)	XP_011509477	P51826
ENST00000427118	AFF3-208	528	-	ENSP00000416131	17 (aa)	-	C9JIB1
ENST00000416492	AFF3-205	545	-	ENSP00000395068	99 (aa)	-	C9JMS1
ENST00000440445	AFF3-211	591	-	ENSP00000393732	155 (aa)	-	C9JUC4
ENST00000432037	AFF3-210	559	-	ENSP00000406484	161 (aa)	-	C9J622
ENST00000498090	AFF3-215	1673	-	-	- (aa)	-	-
ENST00000424600	AFF3-207	551	-	ENSP00000411383	114 (aa)	-	C9J847

Gene Model

Click here to download ENSG00000144218's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000144218	Apolipoproteins E	1.6456952159278E-19	17903299
ENSG00000144218	Apolipoproteins E	6.24225405203388E-19	17903299
ENSG00000144218	Uric Acid	6.8050755579474E-5	17903292
ENSG00000144218	Exercise Test	5.35968467572356E-6	17903301
ENSG00000144218	Exercise Test	3.30381457425335E-7	17903301
ENSG00000144218	Hemoglobin A, Glycosylated	5.2110000E-005	19875614
ENSG00000144218	Hemoglobin A, Glycosylated	2.6990000E-006	19875614
ENSG00000144218	Hemoglobin A, Glycosylated	2.6740000E-006	19875614
ENSG00000144218	Hemoglobin A, Glycosylated	2.8170000E-005	19875614
ENSG00000144218	Hemoglobin A, Glycosylated	3.3130000E-006	19875614
ENSG00000144218	Hemoglobin A, Glycosylated	8.7910000E-005	19875614
ENSG00000144218	Hemoglobin A, Glycosylated	6.3120000E-005	19875614
ENSG00000144218	Body Weights and Measures	1.249e-005	17658951
ENSG00000144218	Body Fat Distribution	5.5560000E-005	-
ENSG00000144218	Coronary Artery Disease	7.0010000E-005	-
ENSG00000144218	Coronary Artery Disease	1.0900000E-005	-
ENSG00000144218	Coronary Artery Disease	4.8670000E-006	-
ENSG00000144218	Coronary Artery Disease	4.6730000E-006	-
ENSG00000144218	Coronary Artery Disease	1.3400000E-005	-
ENSG00000144218	Blood Pressure	6.0560000E-005	-
ENSG00000144218	Blood Pressure	3.9990000E-005	-
ENSG00000144218	Blood Pressure	8.8520000E-005	-
ENSG00000144218	Blood Pressure	1.2260000E-005	-
ENSG00000144218	Blood Pressure	6.8850000E-005	-
ENSG00000144218	Platelet Function Tests	9.5100000E-006	-
ENSG00000144218	Platelet Function Tests	1.1541300E-005	-
ENSG00000144218	Paliperidone Palmitate	2E-6	27846195
ENSG00000144218	Schizophrenia	2E-6	27846195
ENSG00000144218	Diabetic Nephropathies	1E-8	23028342
ENSG00000144218	Diabetic Nephropathies	3E-7	23028342
ENSG00000144218	Education	2E-9	25201988
ENSG00000144218	Marijuana Abuse	2E-6	27028160
ENSG00000144218	Education	1E-9	27225129
ENSG00000144218	Education	4E-19	27225129
ENSG00000144218	Education	9E-28	27225129
ENSG00000144218	Education	2E-11	27225129
ENSG00000144218	Arthritis, Rheumatoid	2E-8	24782177
ENSG00000144218	Diabetic Nephropathies	4E-7	27647854
ENSG00000144218	Renal Insufficiency, Chronic	4E-7	27647854
ENSG00000144218	Education	5E-11	23722424
ENSG00000144218	Arthritis, Rheumatoid	1E-14	20453842

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000144218	rs7579187	2	99725106	G	Intraocular pressure	29617998	[0.057-0.112] unit increase	0.0843	EFO_0004695
ENSG00000144218	rs34795510	2	99992378	?	Cognitive ability	29186694	z score increase	4.978	EFO_0004337
ENSG00000144218	rs34795510	2	99992378	?	Cognitive ability (MTAG)	29186694	z score increase	6.685	EFO_0004337\|EFO_0004784
ENSG00000144218	rs6715849	2	99689916	A	Educational attainment (years of education)	27225129	NR unit decrease	0.015149953	EFO_0004784
ENSG00000144218	rs4851251	2	100137028	T	Educational attainment (years of education)	27225129	NR unit decrease	0.015220452	EFO_0004784
ENSG00000144218	rs7583877	2	99844192	C	Type 1 diabetes nephropathy	23028342	[1.18-1.40]	1.29	EFO_0004996
ENSG00000144218	rs7583877	2	99844192	C	Type 1 diabetes nephropathy	23028342	[1.17-1.42]	1.29	EFO_0004996
ENSG00000144218	rs28425639	2	99936050	T	Response to paliperidone in schizophrenia (negative Marder score)	27846195	[NR] unit decrease	3.0464	EFO_0000692\|EFO_0007925\|EFO_0007927
ENSG00000144218	rs7562121	2	99767892	C	Kidney disease (end stage renal disease vs non-end stage renal disease) in type 1 diabetes	27647854	[1.17-1.39]	1.27	EFO_0004996\|EFO_0003884
ENSG00000144218	rs7601137	2	99743888	T	Mammographic density	25353672	[1.58-3.41]	2.32	EFO_0005941
ENSG00000144218	rs7586604	2	99835214	T	Cannabis dependence symptom count	27028160			EFO_0008457
ENSG00000144218	rs13427251	2	99549992	?	Chronic sinus infection	28928442	[0.054-0.135] unit increase	0.0948	EFO_0008419
ENSG00000144218	rs13032879	2	99986297	T	Intelligence (MTAG)	29326435	[0.021-0.037] unit increase	0.029283281	EFO_0004337
ENSG00000144218	rs2043007	2	99732211	T	Intelligence (MTAG)	29326435	[0.013-0.025] unit increase	0.018892556	EFO_0004337
ENSG00000144218	rs34321437	2	99960959	T	Intelligence (MTAG)	29326435	[0.045-0.076] unit increase	0.06034027	EFO_0004337
ENSG00000144218	rs4851250	2	100112831	T	Intelligence (MTAG)	29326435	[0.025-0.04] unit decrease	0.03202172	EFO_0004337
ENSG00000144218	rs55779933	2	99672640	T	Intelligence (MTAG)	29326435	[0.032-0.064] unit increase	0.047980092	EFO_0004337
ENSG00000144218	rs62154466	2	99575083	A	Intelligence (MTAG)	29326435	[0.039-0.078] unit increase	0.05870441	EFO_0004337
ENSG00000144218	rs6750720	2	100054283	C	Intelligence (MTAG)	29326435	[0.013-0.026] unit decrease	0.019654082	EFO_0004337
ENSG00000144218	rs7579187	2	99725106	A	Intelligence (MTAG)	29326435	[0.013-0.025] unit increase	0.01933111	EFO_0004337
ENSG00000144218	rs56127672	2	99988291	C	Intelligence (MTAG)	29326435	[0.041-0.079] unit increase	0.060207207	EFO_0004337
ENSG00000144218	rs6714788	2	100069711	T	Intelligence (MTAG)	29326435	[0.014-0.026] unit increase	0.019918906	EFO_0004337
ENSG00000144218	rs79785879	2	99900176	T	Intelligence (MTAG)	29326435	[0.042-0.079] unit decrease	0.060496356	EFO_0004337
ENSG00000144218	rs34795510	2	99992378	T	Cognitive performance	30038396	[0.031-0.059] unit increase	0.0452	EFO_0008354
ENSG00000144218	rs6715849	2	99689916	A	Educational attainment (MTAG)	30038396	[0.0087-0.0137] unit decrease	0.0112	EFO_0004784
ENSG00000144218	rs72819118	2	99834895	T	Educational attainment (MTAG)	30038396	[0.018-0.027] unit decrease	0.0223	EFO_0004784
ENSG00000144218	rs17782474	2	99649474	A	Highest math class taken	30038396	[0.015-0.029] unit increase	0.022	EFO_0004875
ENSG00000144218	rs17782474	2	99649474	A	Highest math class taken (MTAG)	30038396	[0.016-0.027] unit increase	0.0212	EFO_0004875
ENSG00000144218	rs17023459	2	100067088	T	Highest math class taken (MTAG)	30038396	[0.0098-0.0192] unit increase	0.0145	EFO_0004875
ENSG00000144218	rs7579187	2	99725106	A	Cognitive performance (MTAG)	30038396	[0.0085-0.0175] unit increase	0.013	EFO_0008354
ENSG00000144218	rs34795510	2	99992378	T	Cognitive performance (MTAG)	30038396	[0.034-0.056] unit increase	0.0451	EFO_0008354
ENSG00000144218	rs10209110	2	100056230	?	Rheumatoid arthritis	23143596		1.1116052	EFO_0000685
ENSG00000144218	rs10209110	2	100056230	?	Rheumatoid arthritis (ACPA-positive)	23143596		1.1223345	EFO_0000685
ENSG00000144218	rs13001130	2	100052237	A	General cognitive ability	29844566	z-score increase	6.352	EFO_0004337
ENSG00000144218	rs34506349	2	99982264	A	General cognitive ability	29844566	z-score increase	5.922	EFO_0004337
ENSG00000144218	rs13023088	2	99959842	T	General cognitive ability	29844566	z-score increase	5.569	EFO_0004337
ENSG00000144218	rs77179555	2	99692662	C	General cognitive ability	29844566	z-score decrease	5.556	EFO_0004337
ENSG00000144218	rs78633727	2	100052995	T	Intelligence	29942086	z-score decrease	6.254	EFO_0004337
ENSG00000144218	rs77909168	2	99939404	C	Refractive astigmatism	30306274	[0.032-0.08] dioptres decrease	0.056	HP_0000483
ENSG00000144218	rs77826402	2	99634927	T	Educational attainment (years of education)	30038396	[0.0098-0.0204] unit increase	0.0151	EFO_0004784
ENSG00000144218	rs6715849	2	99689916	A	Educational attainment (years of education)	30038396	[0.0095-0.0149] unit decrease	0.0122	EFO_0004784
ENSG00000144218	rs13009915	2	99806696	T	Educational attainment (years of education)	30038396	[0.014-0.028] unit increase	0.0212	EFO_0004784
ENSG00000144218	rs72819118	2	99834895	T	Educational attainment (years of education)	30038396	[0.018-0.028] unit decrease	0.0231	EFO_0004784
ENSG00000144218	rs75203411	2	99896691	T	Educational attainment (years of education)	30038396	[0.0098-0.0172] unit increase	0.0135	EFO_0004784
ENSG00000144218	rs6745099	2	100122979	?	Adolescent idiopathic scoliosis	30019117			EFO_0005423
ENSG00000144218	rs17023131	2	99790270	C	Educational attainment (years of education)	30038396	[0.0075-0.0137] unit increase	0.0106	EFO_0004784
ENSG00000144218	rs6719214	2	99990959	?	Menarche (age at onset)	30595370			EFO_0004703
ENSG00000144218	rs62147658	2	99945016	?	Lung function (FVC)	30595370			EFO_0004312
ENSG00000144218	rs4851221	2	99663560	?	Waist-hip ratio	30595370			EFO_0004343
ENSG00000144218	rs10202379	2	99980403	?	Lung function (FEV1/FVC)	30595370			EFO_0004713
ENSG00000144218	rs13392222	2	100055946	C	Alcohol consumption (drinks per week) (MTAG)	30643251	[0.0064-0.0139] unit decrease	0.01011	EFO_0007878
ENSG00000144218	rs13392222	2	100055946	C	Smoking initiation (ever regular vs never regular) (MTAG)	30643251	[0.0089-0.015] unit decrease	0.0119567	EFO_0006527
ENSG00000144218	rs13392222	2	100055946	C	Smoking initiation (ever regular vs never regular)	30643251	[0.016-0.031] unit decrease	0.023437547	EFO_0006527

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000144218's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000144218	AFF3	97	50.000	ENSG00000072364	AFF4	61	59.341
ENSG00000144218	AFF3	98	64.948	ENSG00000155966	AFF2	85	58.889
ENSG00000144218	AFF3	92	49.112	ENSG00000172493	AFF1	56	56.818

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000144218	AFF3	98	63.102	ENSAMEG00000014934	AFF2	84	60.227	Ailuropoda_melanoleuca
ENSG00000144218	AFF3	99	91.000	ENSAMEG00000013204	-	100	90.957	Ailuropoda_melanoleuca
ENSG00000144218	AFF3	97	51.020	ENSAMEG00000017764	AFF4	99	35.870	Ailuropoda_melanoleuca
ENSG00000144218	AFF3	89	93.007	ENSAMEG00000015682	-	99	84.262	Ailuropoda_melanoleuca
ENSG00000144218	AFF3	64	61.538	ENSACIG00000010592	-	51	61.538	Amphilophus_citrinellus
ENSG00000144218	AFF3	57	51.786	ENSACIG00000021066	-	95	31.975	Amphilophus_citrinellus
ENSG00000144218	AFF3	90	43.915	ENSACIG00000010525	aff4	74	30.912	Amphilophus_citrinellus
ENSG00000144218	AFF3	91	60.326	ENSACIG00000022732	aff2	81	61.765	Amphilophus_citrinellus
ENSG00000144218	AFF3	91	58.919	ENSAPEG00000015300	aff2	84	63.095	Amphiprion_percula
ENSG00000144218	AFF3	96	38.265	ENSATEG00000015552	-	60	50.685	Anabas_testudineus
ENSG00000144218	AFF3	98	59.794	ENSATEG00000017794	aff2	59	59.794	Anabas_testudineus
ENSG00000144218	AFF3	98	50.000	ENSATEG00000010963	aff4	86	61.538

EuRBPDB

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Description

RBDs

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PPI

Paralogs

Orthologs

Gene Ontology

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