EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
26413750LYAR promotes colorectal cancer cell mobility by activating galectin-1 expression.Oncotarget2015 Oct 20Wu Ydoi: 10.18632/oncotarget.5335.
24990247Lyar, a cell growth-regulating zinc finger protein, was identified to be associated with cytoplasmic ribosomes in male germ and cancer cells.Mol Cell Biochem2014 OctYonezawa Kdoi: 10.1007/s11010-014-2128-x

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr44274622Missense_MutationNAE193K0.2
BRCAchr44274627Missense_MutationNAR191T0.23
BRCAchr44267920Nonsense_MutationNAL370*0.3
BRCAchr44274584SilentnovelE205E0.05
CESCchr44274590Missense_Mutationrs143281420K203N0.59
CESCchr44279717Silentrs767294372V90V0.31
COADchr44283708Missense_MutationNAS12L0.21
COADchr44274424Missense_Mutationrs757496286A259T0.31
COADchr44274436Missense_Mutationrs756569454R255C0.13
COADchr44281875Missense_Mutationrs151107558V49M0.34
COADchr44283731Frame_Shift_DelNAF4Lfs*100.43
COADchr44281894Silentrs770633401G42G0.09
COADchr44274745Nonsense_MutationnovelQ152*0.13
COADchr44283731Frame_Shift_DelNAF4Lfs*100.45
COADchr44273645Frame_Shift_DelNAK286Rfs*20.4
COADchr44268580Frame_Shift_InsnovelL319Vfs*100.04
COADchr44283731Frame_Shift_DelNAF4Lfs*100.26
COADchr44281894Silentrs770633401G42G0.09
ESCAchr44283681Missense_Mutationrs761005527H21R0.31
GBMchr44273638SilentnovelK288K0.09
GBMchr44281893Missense_Mutationrs532794150D43N0.59
GBMchr442677793'UTRnovel0.82
GBMchr44279503Missense_MutationnovelH125N0.11
HNSCchr44279483Missense_MutationnovelD131E0.42
HNSCchr44274634Frame_Shift_DelnovelE190Kfs*310.11
HNSCchr442678153'UTRnovel0.38
KIRPchr44274644Frame_Shift_DelnovelV184Efs*30.07
KIRPchr44268544Nonsense_MutationnovelK331*0.15
KIRPchr44274615Missense_Mutationrs778654068R195Q0.47
LAMLchr44274418Missense_MutationnovelE261K0.03
LGGchr442678843'UTRnovel0.12
LIHCchr44273661Missense_MutationNAD281N0.28
LIHCchr44281866Missense_MutationNAI52V0.45
LUADchr44281827Missense_MutationnovelG65C0.04
LUADchr44281790Nonsense_MutationNAW77*0.08
LUADchr44273619Missense_MutationnovelG295S0.14
LUADchr44274411Missense_MutationNAE263V0.38
LUADchr44273619Missense_MutationNAG295C0.15
LUADchr44274769Nonsense_MutationNAE144*0.06
LUADchr44283714Missense_MutationnovelG10V0.13
LUADchr44283683SilentNAK20K0.25
LUADchr44268007Missense_MutationNAY341C0.16
LUADchr44273601Missense_MutationNAD301Y0.16
LUSCchr44268007Missense_MutationNAY341C0.26
LUSCchr44274636Missense_MutationnovelK188I0.33
LUSCchr44273580Splice_Regionrs7808436070.28
LUSCchr44279517Missense_MutationnovelN120I0.17
LUSCchr44283706Missense_MutationnovelV13L0.35
OVchr44283719SilentNAA8A0.6
OVchr44283723Missense_MutationNAN7S0.4
OVchr44274403Missense_Mutationrs752653540V266M0.47
OVchr44267999Missense_MutationnovelT344A0.04
OVchr44268556Frame_Shift_DelNAI327*0.43
OVchr44274642Missense_MutationnovelK186M0.11
PRADchr44279666SilentNAV107V0.19
PRADchr44283680Silentrs572890068H21H0.44
READchr44283635Silentrs528236112C36C0.14
READchr44268608Missense_MutationNAF309L0.2
READchr44279468SilentnovelI136I0.39
SARCchr44274665SilentnovelV178V0.07
SKCMchr44279493Missense_MutationNAS128F0.37
SKCMchr44283739Missense_MutationnovelV2L0.39
STADchr44281793Missense_MutationNAA76E0.17
STADchr44268542Frame_Shift_InsnovelL332Afs*150.2
STADchr44283683Missense_MutationNAK20N0.53
STADchr44283731Frame_Shift_DelNAF4Lfs*100.36
STADchr442677693'UTRnovel0.5
STADchr44281790Missense_MutationNAW77L0.17
THCAchr44274485SilentNAV238V0.46
UCECchr44274608Missense_MutationnovelK197N0.03
UCECchr44274756Missense_MutationnovelK148T0.35
UCECchr44281893Missense_Mutationrs532794150D43N0.09
UCECchr442677353'UTRnovel0.38
UCECchr44279527Missense_MutationnovelW117R0.38
UCECchr44279468Silentrs763209438I136I0.11
UCECchr44274394Missense_MutationnovelG269W0.1
UCECchr44283635Silentrs528236112C36C0.37
UCECchr44283703Missense_MutationnovelK14Q0.16
UCECchr442837905'UTRnovel0.3
UCECchr44274398Silentrs776356297G267G0.41
UCECchr44274437SilentnovelQ254Q0.07
UCECchr44283628Missense_MutationnovelD39N0.05
UCECchr44281881Missense_MutationnovelN47Y0.21
UCECchr44273657Missense_MutationnovelS282Y0.26
UCECchr44273583Missense_MutationnovelG307S0.31
UCECchr44279668Missense_Mutationrs377617456V107I0.36
UCECchr442677763'UTRnovel0.44
UCECchr44267978Missense_Mutationrs753033913E351K0.43
UCECchr44279531Splice_Siters781218982X116_splice0.18
UCECchr44274500SilentnovelA233A0.36
UCECchr44274590Missense_Mutationrs143281420K203N0.08
UCECchr44274436Missense_Mutationrs756569454R255C0.38
UCECchr44283635Silentrs528236112C36C0.37
UCECchr44273629SilentNAE291E0.16
UCECchr44274478Missense_MutationNAA241T0.26
UCECchr44274736Missense_MutationNAL155I0.13
UCECchr44274532Missense_Mutationrs138454561R223C0.26

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
CESCDEL0.36950.12975
COADDEL0.26160.14844
HNSCDEL0.34290.00046209
LIHCDEL0.19460.14149
LUADDEL0.14530.16034
SKCMDEL0.17440.09333
UCECDEL0.14660.013734

Survival Analysis
CancerP-value Q-value
KIRC0.0021

Kaplan-Meier Survival Analysis

MESO0.0018

Kaplan-Meier Survival Analysis

ACC0.0027

Kaplan-Meier Survival Analysis

HNSC0.047

Kaplan-Meier Survival Analysis

PRAD0.025

Kaplan-Meier Survival Analysis

KIRP0.00011

Kaplan-Meier Survival Analysis

PAAD0.0089

Kaplan-Meier Survival Analysis

LAML0.041

Kaplan-Meier Survival Analysis

KICH0.014

Kaplan-Meier Survival Analysis

UCEC0.01

Kaplan-Meier Survival Analysis

LIHC0.00033

Kaplan-Meier Survival Analysis

LGG0.025

Kaplan-Meier Survival Analysis

LUAD0.00047

Kaplan-Meier Survival Analysis

OV0.00051

Kaplan-Meier Survival Analysis

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000145220 (Gene tree)
Gene ID
55646
Gene Symbol
LYAR
Alias
ZC2HC2|ZLYAR
Full Name
Ly1 antibody reactive
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
22,469 bases
Position
chr4:4,267,701-4,290,169
Accession
26021
RBP type
non-canonical RBP
Summary
(Ly1 Antibody Reactive) is a Protein Coding gene. Diseases associated with LYAR include Neuroblastoma.
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
30209172The Nucleolar Protein LYAR Facilitates Ribonucleoprotein Assembly of Influenza A Virus.J Virol2018 Nov 12Yang Cdoi: 10.1128/JVI.01042-18
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000452476LYAR-2021468XM_011513505ENSP00000397367379 (aa)XP_011511807Q9NX58
ENST00000502917LYAR-203726--- (aa)--
ENST00000513174LYAR-204780-ENSP0000042090279 (aa)-D6RDJ1
ENST00000343470LYAR-2011569XM_011513506ENSP00000345917379 (aa)XP_011511808Q9NX58
Gene Model
Click here to download ENSG00000145220's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000145220Platelet Function Tests3.0301200E-005-
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000145220rs15093834144271082CDisease progression in age-related macular degeneration293466441.73EFO_0001365|EFO_0008336
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000145220's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000145220LYAR10093.671ENSMUSG00000067367Lyar10097.500Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000122negative regulation of transcription by RNA polymerase II25092918.IMPProcess
GO:0001750photoreceptor outer segment-ISSComponent
GO:0003677DNA binding25092918.IDAFunction
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0005515protein binding21516116.22720776.25092918.25416956.30177828.IPIFunction
GO:0005634nucleus22720776.25092918.IDAComponent
GO:0005730nucleolus24495227.IDAComponent
GO:0005737cytoplasm-IEAComponent
GO:0006364rRNA processing24495227.IMPProcess
GO:0046872metal ion binding-IEAFunction
GO:0048821erythrocyte development25092918.IMPProcess
GO:0050766positive regulation of phagocytosis-ISSProcess
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