EuRBPDB

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Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr6	30684475	Missense_Mutation	novel	L515P	0.07
BLCA	chr6	30685006	Missense_Mutation	novel	S338C	0.48
BLCA	chr6	30685520	Missense_Mutation	NA	L167M	0.33
BLCA	chr6	30685225	Missense_Mutation	novel	S265L	0.07
BLCA	chr6	30685162	Missense_Mutation	novel	G286V	0.19
BLCA	chr6	30684971	Missense_Mutation	NA	E350Q	0.04
BLCA	chr6	30684994	Missense_Mutation	novel	R342P	0.21
BRCA	chr6	30679389	Missense_Mutation	novel	L538F	0.33
CESC	chr6	30685536	In_Frame_Ins	novel	E161delinsDSPG	0.06
CHOL	chr6	30685394	Missense_Mutation	novel	S209T	0.41
COAD	chr6	30685523	Missense_Mutation	NA	P166T	0.31
COAD	chr6	30684468	Silent	NA	G517G	0.35
COAD	chr6	30685130	Missense_Mutation	rs753123312	E297K	0.18
COAD	chr6	30679212	Nonsense_Mutation	NA	Q597*	0.44
COAD	chr6	30679213	Silent	NA	L596L	0.42
COAD	chr6	30685651	Missense_Mutation	NA	R123K	0.47
COAD	chr6	30685930	Missense_Mutation	rs200269206	R30Q	0.29
COAD	chr6	30686072	5'UTR	novel		0.5
COAD	chr6	30685732	Missense_Mutation	rs775362882	Q96R	0.16
COAD	chr6	30684642	Silent	novel	G459G	0.29
COAD	chr6	30677115	3'UTR	novel		0.35
COAD	chr6	30685735	Missense_Mutation	NA	R95Q	0.19
COAD	chr6	30684425	Missense_Mutation	rs555488215	E532K	0.22
DLBC	chr6	30685111	Missense_Mutation	novel	A303D	0.08
ESCA	chr6	30684454	Missense_Mutation	novel	S522N	0.42
ESCA	chr6	30685634	Missense_Mutation	novel	M129V	0.44
ESCA	chr6	30685059	Silent	novel	E320E	0.44
GBM	chr6	30685137	Silent	novel	E294E	0.23
GBM	chr6	30685654	Missense_Mutation	rs780349967	R122Q	0.66
GBM	chr6	30684613	Nonsense_Mutation	novel	G469delinsALPI*	0.22
GBM	chr6	30679341	Missense_Mutation	novel	P554S	0.13
HNSC	chr6	30679320	Missense_Mutation	novel	E561Q	0.35
HNSC	chr6	30685754	Nonsense_Mutation	novel	R89*	0.48
HNSC	chr6	30686028	5'UTR	novel		0.1
KIRC	chr6	30684829	Missense_Mutation	novel	C397Y	0.24
LAML	chr6	30677120	3'UTR	novel		0.16
LAML	chr6	30686112	5'UTR	novel		0.19
LIHC	chr6	30684420	Missense_Mutation	novel	R533S	0.58
LUAD	chr6	30679231	Silent	NA	L590L	0.22
LUAD	chr6	30685600	Missense_Mutation	novel	R140T	0.07
LUAD	chr6	30685974	Silent	NA	R15R	0.21
LUAD	chr6	30685918	Missense_Mutation	rs755337750	S34F	0.24
LUAD	chr6	30684631	Missense_Mutation	NA	G463A	0.33
LUSC	chr6	30686537	5'UTR	novel		0.63
LUSC	chr6	30685595	Nonsense_Mutation	NA	E142*	0.13
LUSC	chr6	30685140	Silent	novel	A293A	0.1
LUSC	chr6	30677266	3'UTR	novel		0.34
OV	chr6	30684460	Missense_Mutation	novel	R520L	0.09
OV	chr6	30684859	Missense_Mutation	novel	G387A	0.11
OV	chr6	30686300	5'UTR	novel		0.33
OV	chr6	30685542	Silent	NA	A159A	0.41
OV	chr6	30679177	Splice_Site	novel	X608_splice	0.2
OV	chr6	30685302	Missense_Mutation	novel	H239Q	0.04
OV	chr6	30686300	5'UTR	novel		0.19
PAAD	chr6	30679249	Missense_Mutation	novel	E584D	0.1
READ	chr6	30685111	Missense_Mutation	NA	A303V	0.43
READ	chr6	30685554	Silent	NA	G155G	0.41
SARC	chr6	30679314	Missense_Mutation	novel	L563M	0.05
SARC	chr6	30684866	Missense_Mutation	novel	A385T	0.5
SKCM	chr6	30685513	Missense_Mutation	novel	A169V	0.33
SKCM	chr6	30677133	3'UTR	novel		0.54
SKCM	chr6	30684592	Missense_Mutation	NA	P476L	0.67
SKCM	chr6	30684552	Silent	NA	T489T	0.16
SKCM	chr6	30685745	Missense_Mutation	rs751082280	R92W	0.23
SKCM	chr6	30685947	Silent	NA	G24G	0.45
SKCM	chr6	30685251	Silent	novel	L256L	0.35
SKCM	chr6	30685878	Silent	novel	R47R	0.06
SKCM	chr6	30685013	Silent	NA	L336L	0.61
SKCM	chr6	30685493	Missense_Mutation	novel	P176S	0.3
STAD	chr6	30685744	Missense_Mutation	NA	R92Q	0.14
STAD	chr6	30684460	Missense_Mutation	rs758480498	R520H	0.33
STAD	chr6	30685323	Silent	novel	K232K	0.25
STAD	chr6	30685530	Silent	NA	S163S	0.06
STAD	chr6	30684896	Missense_Mutation	novel	E375K	0.11
STAD	chr6	30685061	Nonsense_Mutation	novel	E320*	0.08
STAD	chr6	30685891	Missense_Mutation	novel	L43P	0.15
STAD	chr6	30686192	5'UTR	novel		0.5
STAD	chr6	30685692	Silent	NA	L109L	0.07
STAD	chr6	30684623	Frame_Shift_Del	novel	*R466Afs140**	0.46
TGCT	chr6	30684413	Nonsense_Mutation	novel	K536*	0.2
UCEC	chr6	30677036	3'UTR	novel		0.38
UCEC	chr6	30684523	Missense_Mutation	novel	P499Q	0.64
UCEC	chr6	30679342	Silent	NA	Y553Y	0.25
UCEC	chr6	30684544	Missense_Mutation	novel	A492V	0.23
UCEC	chr6	30677205	3'UTR	novel		0.65
UCEC	chr6	30677021	3'UTR	novel		0.38
UCEC	chr6	30679339	Silent	novel	P554P	0.07
UCEC	chr6	30685440	Silent	novel	R193R	0.3
UCEC	chr6	30685800	Silent	novel	D73D	0.4
UCEC	chr6	30685544	Missense_Mutation	novel	A159T	0.32
UCEC	chr6	30685200	Silent	rs148416074	S273S	0.33
UCEC	chr6	30677021	3'UTR	novel		0.34
UCEC	chr6	30684955	Missense_Mutation	novel	K355R	0.4
UCEC	chr6	30685630	Missense_Mutation	novel	R130Q	0.41
UCEC	chr6	30685156	Missense_Mutation	novel	A288V	0.4
UCEC	chr6	30677057	3'UTR	novel		0.3
UCEC	chr6	30679339	Silent	novel	P554P	0.33
UCEC	chr6	30685045	Missense_Mutation	novel	G325D	0.29
UCEC	chr6	30676889	3'UTR	rs779980964		0.16
UCEC	chr6	30684812	Frame_Shift_Del	NA	*L403Sfs11**	0.53
UCEC	chr6	30685553	Missense_Mutation	novel	I156V	0.26
UCEC	chr6	30685390	Missense_Mutation	rs376250744	R210Q	0.39
UCEC	chr6	30676889	3'UTR	rs779980964		0.31
UCEC	chr6	30685605	Missense_Mutation	novel	E138D	0.32
UCEC	chr6	30685708	Missense_Mutation	NA	R104Q	0.2
UCEC	chr6	30684648	Missense_Mutation	novel	K457N	0.6
UCEC	chr6	30684448	Missense_Mutation	novel	S524N	0.21
UCEC	chr6	30684930	Missense_Mutation	rs570662593	E363D	0.21
UCEC	chr6	30677171	3'UTR	NA		0.22
UCEC	chr6	30685965	Missense_Mutation	NA	E18D	0.3
UCEC	chr6	30686446	5'UTR	novel		0.5
UCEC	chr6	30676916	3'UTR	novel		0.18
UCEC	chr6	30685241	Missense_Mutation	novel	E260K	0.33
UCS	chr6	30679236	Silent	novel	L589L	0.35
UVM	chr6	30685956	Silent	novel	S21S	0.49

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value

Survival Analysis

Cancer	P-value	Q-value
MESO	0.00016	Kaplan-Meier Survival Analysis
SKCM	0.029	Kaplan-Meier Survival Analysis
ESCA	0.019	Kaplan-Meier Survival Analysis
KIRP	0.00047	Kaplan-Meier Survival Analysis
COAD	0.01	Kaplan-Meier Survival Analysis
LAML	0.0014	Kaplan-Meier Survival Analysis
GBM	0.047	Kaplan-Meier Survival Analysis
LIHC	0.036	Kaplan-Meier Survival Analysis
LGG	0.0013	Kaplan-Meier Survival Analysis

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000146112 (Gene tree)
Gene ID: 170954
Gene Symbol: PPP1R18
Alias: phostensin|KIAA1949
Full Name: protein phosphatase 1 regulatory subunit 18
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 11,507 bases
Position: chr6:30,676,389-30,687,895
Accession: 29413
RBP type: non-canonical RBP
Summary: Protein phosphatase-1 (PP1; see MIM 176875) interacts with regulatory subunits that target the enzyme to different cellular locations and change its activity toward specific substrates. Phostensin is a regulatory subunit that targets PP1 to F-actin (see MIM 102610) cytoskeleton (Kao et al., 2007 [PubMed 17374523]).[supplied by OMIM, Mar 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000488324	PPP1R18-204	1328	-	-	- (aa)	-	-
ENST00000615527	PPP1R18-205	4597	-	ENSP00000480270	613 (aa)	-	Q6NYC8
ENST00000274853	PPP1R18-201	4599	-	ENSP00000274853	613 (aa)	-	Q6NYC8
ENST00000399199	PPP1R18-202	2853	-	ENSP00000382150	613 (aa)	-	Q6NYC8
ENST00000467662	PPP1R18-203	1156	-	-	- (aa)	-	-
ENST00000615892	PPP1R18-206	1448	-	ENSP00000482578	165 (aa)	-	Q6NYC8

Gene Model

Click here to download ENSG00000146112's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000146112	Platelet Function Tests	1.2398600E-005	-
ENSG00000146112	Alcoholism	3E-10	27151647

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000146112	rs116295105	6	30685004	T	Lung cancer	28604730	[1.136875795-1.225357708]	1.1802878	EFO_0001071
ENSG00000146112	rs9262142	6	30682249	A	Breast cancer	29059683	[0.028-0.069] unit decrease	0.0489	EFO_0000305

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000146112's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003779	actin binding	-	IEA	Function
GO:0005515	protein binding	21516116.22321011.25416956.25593058.28330616.	IPI	Function
GO:0005737	cytoplasm	-	IEA	Component
GO:0005856	cytoskeleton	-	IEA	Component
GO:0019902	phosphatase binding	-	IEA	Function

Note: Click here to get the extension of tumor abbreviations.

Note: to get the extension of tumor abbreviations.