EuRBPDB

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TCGA tumor abbreviations
  • ACCAdrenocortical carcinoma
  • BLCABladder Urothelial Carcinoma
  • BRCABreast invasive carcinoma
  • CESCCervical squamous cell carcinoma and endocervical adenocarcinoma
  • CHOLCholangio carcinoma
  • COADColon adenocarcinoma
  • DLBCLymphoid Neoplasm Diffuse Large B-cell Lymphoma
  • ESCAEsophageal carcinoma
  • GBMGlioblastoma multiforme
  • HNSCHead and Neck squamous cell carcinoma
  • KICHKidney Chromophobe
  • KIRCKidney renal clear cell carcinoma
  • KIRPKidney renal papillary cell carcinoma
  • LAMLAcute Myeloid Leukemia
  • LGGBrain Lower Grade Glioma
  • LIHCLiver hepatocellular carcinoma
  • LUADLung adenocarcinoma
  • LUSCLung squamous cell carcinoma
  • MESOMesothelioma
  • OVOvarian serous cystadenocarcinoma
  • PAADPancreatic adenocarcinoma
  • PCPGPheochromocytoma and Paraganglioma
  • PRADProstate adenocarcinoma
  • READRectum adenocarcinoma
  • SARCSarcoma
  • SKCMSkin Cutaneous Melanoma
  • STADStomach adenocarcinoma
  • TGCTThyroid carcinoma
  • THCAThyroid carcinoma
  • THYMThymoma
  • UCECUterine Corpus Endometrial Carcinoma
  • UCSUterine Carcinosarcoma
  • UVMUveal Melanoma

Note: Click here to get the extension of tumor abbreviations.


  • Cancer Related Information
  • Basic Information

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr657318478SilentNAL11L0.36
BRCAchr657382341Intronnovel0.13
BRCAchr657382343Intronnovel0.13
BRCAchr657382326Intronnovel0.63
CESCchr657379915Missense_MutationnovelE158D0.35
CESCchr6573176345'UTRnovel0.35
COADchr657324228Nonsense_MutationNAR96*0.37
COADchr657382116Missense_MutationNAI214N0.38
COADchr657318566Nonsense_MutationNAE41*0.22
COADchr657382174Splice_Regionnovel0.28
COADchr657324279Missense_MutationnovelS113T0.06
COADchr657320473Missense_MutationNAE57D0.29
COADchr657382151Nonsense_MutationnovelL226delinsQAK*V0.06
GBMchr657324212Missense_Mutationrs746110249E90D0.37
GBMchr657382194Intronnovel0.09
KIRCchr657320484Missense_MutationNAV61E0.33
KIRCchr657320512SilentnovelY70Y0.36
KIRPchr657382051SilentNAL192L0.43
KIRPchr657382052Missense_MutationNAD193Y0.43
LGGchr657320456Splice_SiteNAX52_splice0.24
LUADchr657324281Splice_SitenovelX113_splice0.33
LUADchr657318498Missense_MutationNAR18M0.4
LUSCchr657318508SilentnovelS21S0.4
LUSCchr657326095Intronnovel0.33
READchr657382095Missense_MutationnovelA207D0.03
READchr657318566Nonsense_MutationNAE41*0.5
SARCchr657379910Frame_Shift_DelnovelE157Gfs*130.29
SARCchr657324260Missense_MutationnovelL106F0.11
SKCMchr657382136Nonsense_MutationNAE221*0.21
SKCMchr657326007Nonsense_MutationnovelQ141*0.29
SKCMchr657382074Missense_MutationNAV200D0.43
STADchr657325938Missense_Mutationrs753764529R118C0.37
STADchr657318504Missense_MutationnovelA20V0.27
THYMchr657390206Intronnovel0.23
UCECchr657379926Missense_Mutationrs766118849R162Q0.28
UCECchr657318471Missense_MutationnovelR9K0.14
UCECchr657382062Missense_Mutationrs765390262R196Q0.4
UCECchr657390157Intronnovel0.39
UCECchr657326274Intronnovel0.33
UCECchr657382036SilentNAP187P0.37
UCECchr657325972Missense_MutationnovelR129Q0.1
UCECchr657325929Nonsense_MutationnovelE115*0.44
UCECchr657324237Missense_MutationnovelD99Y0.47
UCECchr657326302Intronnovel0.31
UCECchr657382085Missense_MutationnovelD204Y0.16
UCECchr657325972Missense_MutationnovelR129Q0.54
UCECchr657320461Frame_Shift_DelnovelK54Nfs*80.36
UCECchr657326010Missense_MutationnovelD142Y0.39
UCECchr657390158Intronnovel0.41
UCECchr657318566Nonsense_MutationNAE41*0.45
UCSchr657318538SilentnovelQ31Q0.36

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
KIRPDEL0.07640.11427
LUADDEL0.11240.0021365

Survival Analysis
CancerP-value Q-value
THYM0.0025

Kaplan-Meier Survival Analysis

SARC0.001

Kaplan-Meier Survival Analysis

ACC0.011

Kaplan-Meier Survival Analysis

LUSC0.017

Kaplan-Meier Survival Analysis

KIRP0.00029

Kaplan-Meier Survival Analysis

PAAD0.0016

Kaplan-Meier Survival Analysis

CESC0.023

Kaplan-Meier Survival Analysis

KICH0.0028

Kaplan-Meier Survival Analysis

UCEC0.0018

Kaplan-Meier Survival Analysis

LIHC0.00012

Kaplan-Meier Survival Analysis

LGG0.0016

Kaplan-Meier Survival Analysis

UVM0.0072

Kaplan-Meier Survival Analysis

OV0.0001

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000146143 (Gene tree)
Gene ID
5558
Gene Symbol
PRIM2
Alias
PRIM2A
Full Name
DNA primase subunit 2
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
332,046 bases
Position
chr6:57,314,805-57,646,850
Accession
9370
RBP type
non-canonical RBP
Summary
This gene encodes the 58 kilodalton subunit of DNA primase, an enzyme that plays a key role in the replication of DNA. The encoded protein forms a heterodimer with a 49 kilodalton subunit. This heterodimer functions as a DNA-directed RNA polymerase to synthesize small RNA primers that are used to create Okazaki fragments on the lagging strand of the DNA. Alternative splicing of this gene results in multiple transcript variants. This gene has a related pseudogene, which is also present on chromosome 6. [provided by RefSeq, Apr 2014]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
21346410Crystal structure of the C-terminal domain of human DNA primase large subunit: implications for the mechanism of the primase-polymerase α switch.Cell Cycle2011 Mar 15Agarkar VB-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000550475PRIM2-206375-ENSP0000048539593 (aa)-A0A096LP51
ENST00000470638PRIM2-204486--- (aa)--
ENST00000615550PRIM2-2072308XM_017011004ENSP00000484105509 (aa)XP_016866493P49643
ENST00000370687PRIM2-202909-ENSP00000483201158 (aa)-P49643
ENST00000274891PRIM2-201864-ENSP00000485304158 (aa)-P49643
ENST00000490313PRIM2-205410--- (aa)--
ENST00000419977PRIM2-2032197--- (aa)--
Gene Model
Click here to download ENSG00000146143's gene model file
Pathways
Pathway IDPathway NameSource
hsa03030DNA replicationKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000146143Arteries6.7250000E-005-
ENSG00000146143Ankle Brachial Index3.4050031E-005-
ENSG00000146143Ankle Brachial Index8.2186358E-005-
ENSG00000146143Ankle Brachial Index3.7276687E-005-
ENSG00000146143Ankle Brachial Index3.3854710E-005-
ENSG00000146143Ankle Brachial Index1.9461675E-005-
ENSG0000014614325-Hydroxyvitamin D 24.3180000E-005-
ENSG00000146143Longevity4E-627015805
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000146143rs3800007657372179?Parental extreme longevity (95 years and older)27015805[0.0071-0.0177] unit decrease0.01239EFO_0007796
ENSG00000146143rs2013268657404607ARed vs. brown/black hair color30531825NR288.8EFO_0003924
ENSG00000146143rs9476035657494269?Lung function (FEV1/FVC)30595370EFO_0004713
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000146143's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000082G1/S transition of mitotic cell cycle-TASProcess
GO:0003697single-stranded DNA binding21873635.IBAFunction
GO:0003896DNA primase activity21873635.IBAFunction
GO:0005654nucleoplasm-TASComponent
GO:0005658alpha DNA polymerase:primase complex21873635.IBAComponent
GO:0006269DNA replication, synthesis of RNA primer-IEAProcess
GO:0006270DNA replication initiation-TASProcess
GO:0032201telomere maintenance via semi-conservative replication-TASProcess
GO:0046872metal ion binding-IEAFunction
GO:00515394 iron, 4 sulfur cluster binding-IEAFunction
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