EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr6	57318478	Silent	NA	L11L	0.36
BRCA	chr6	57382341	Intron	novel		0.13
BRCA	chr6	57382343	Intron	novel		0.13
BRCA	chr6	57382326	Intron	novel		0.63
CESC	chr6	57379915	Missense_Mutation	novel	E158D	0.35
CESC	chr6	57317634	5'UTR	novel		0.35
COAD	chr6	57324228	Nonsense_Mutation	NA	R96*	0.37
COAD	chr6	57382116	Missense_Mutation	NA	I214N	0.38
COAD	chr6	57318566	Nonsense_Mutation	NA	E41*	0.22
COAD	chr6	57382174	Splice_Region	novel		0.28
COAD	chr6	57324279	Missense_Mutation	novel	S113T	0.06
COAD	chr6	57320473	Missense_Mutation	NA	E57D	0.29
COAD	chr6	57382151	Nonsense_Mutation	novel	*L226delinsQAKV**	0.06
GBM	chr6	57324212	Missense_Mutation	rs746110249	E90D	0.37
GBM	chr6	57382194	Intron	novel		0.09
KIRC	chr6	57320484	Missense_Mutation	NA	V61E	0.33
KIRC	chr6	57320512	Silent	novel	Y70Y	0.36
KIRP	chr6	57382051	Silent	NA	L192L	0.43
KIRP	chr6	57382052	Missense_Mutation	NA	D193Y	0.43
LGG	chr6	57320456	Splice_Site	NA	X52_splice	0.24
LUAD	chr6	57324281	Splice_Site	novel	X113_splice	0.33
LUAD	chr6	57318498	Missense_Mutation	NA	R18M	0.4
LUSC	chr6	57318508	Silent	novel	S21S	0.4
LUSC	chr6	57326095	Intron	novel		0.33
READ	chr6	57382095	Missense_Mutation	novel	A207D	0.03
READ	chr6	57318566	Nonsense_Mutation	NA	E41*	0.5
SARC	chr6	57379910	Frame_Shift_Del	novel	*E157Gfs13**	0.29
SARC	chr6	57324260	Missense_Mutation	novel	L106F	0.11
SKCM	chr6	57382136	Nonsense_Mutation	NA	E221*	0.21
SKCM	chr6	57326007	Nonsense_Mutation	novel	Q141*	0.29
SKCM	chr6	57382074	Missense_Mutation	NA	V200D	0.43
STAD	chr6	57325938	Missense_Mutation	rs753764529	R118C	0.37
STAD	chr6	57318504	Missense_Mutation	novel	A20V	0.27
THYM	chr6	57390206	Intron	novel		0.23
UCEC	chr6	57379926	Missense_Mutation	rs766118849	R162Q	0.28
UCEC	chr6	57318471	Missense_Mutation	novel	R9K	0.14
UCEC	chr6	57382062	Missense_Mutation	rs765390262	R196Q	0.4
UCEC	chr6	57390157	Intron	novel		0.39
UCEC	chr6	57326274	Intron	novel		0.33
UCEC	chr6	57382036	Silent	NA	P187P	0.37
UCEC	chr6	57325972	Missense_Mutation	novel	R129Q	0.1
UCEC	chr6	57325929	Nonsense_Mutation	novel	E115*	0.44
UCEC	chr6	57324237	Missense_Mutation	novel	D99Y	0.47
UCEC	chr6	57326302	Intron	novel		0.31
UCEC	chr6	57382085	Missense_Mutation	novel	D204Y	0.16
UCEC	chr6	57325972	Missense_Mutation	novel	R129Q	0.54
UCEC	chr6	57320461	Frame_Shift_Del	novel	*K54Nfs8**	0.36
UCEC	chr6	57326010	Missense_Mutation	novel	D142Y	0.39
UCEC	chr6	57390158	Intron	novel		0.41
UCEC	chr6	57318566	Nonsense_Mutation	NA	E41*	0.45
UCS	chr6	57318538	Silent	novel	Q31Q	0.36

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	DEL	0.0764	0.11427
LUAD	DEL	0.1124	0.0021365

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0025	Kaplan-Meier Survival Analysis
SARC	0.001	Kaplan-Meier Survival Analysis
ACC	0.011	Kaplan-Meier Survival Analysis
LUSC	0.017	Kaplan-Meier Survival Analysis
KIRP	0.00029	Kaplan-Meier Survival Analysis
PAAD	0.0016	Kaplan-Meier Survival Analysis
CESC	0.023	Kaplan-Meier Survival Analysis
KICH	0.0028	Kaplan-Meier Survival Analysis
UCEC	0.0018	Kaplan-Meier Survival Analysis
LIHC	0.00012	Kaplan-Meier Survival Analysis
LGG	0.0016	Kaplan-Meier Survival Analysis
UVM	0.0072	Kaplan-Meier Survival Analysis
OV	0.0001	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000146143 (Gene tree)
Gene ID: 5558
Gene Symbol: PRIM2
Alias: PRIM2A
Full Name: DNA primase subunit 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 332,046 bases
Position: chr6:57,314,805-57,646,850
Accession: 9370
RBP type: non-canonical RBP
Summary: This gene encodes the 58 kilodalton subunit of DNA primase, an enzyme that plays a key role in the replication of DNA. The encoded protein forms a heterodimer with a 49 kilodalton subunit. This heterodimer functions as a DNA-directed RNA polymerase to synthesize small RNA primers that are used to create Okazaki fragments on the lagging strand of the DNA. Alternative splicing of this gene results in multiple transcript variants. This gene has a related pseudogene, which is also present on chromosome 6. [provided by RefSeq, Apr 2014]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
21346410	Crystal structure of the C-terminal domain of human DNA primase large subunit: implications for the mechanism of the primase-polymerase α switch.	Cell Cycle	2011 Mar 15	Agarkar VB	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000550475	PRIM2-206	375	-	ENSP00000485395	93 (aa)	-	A0A096LP51
ENST00000470638	PRIM2-204	486	-	-	- (aa)	-	-
ENST00000615550	PRIM2-207	2308	XM_017011004	ENSP00000484105	509 (aa)	XP_016866493	P49643
ENST00000370687	PRIM2-202	909	-	ENSP00000483201	158 (aa)	-	P49643
ENST00000274891	PRIM2-201	864	-	ENSP00000485304	158 (aa)	-	P49643
ENST00000490313	PRIM2-205	410	-	-	- (aa)	-	-
ENST00000419977	PRIM2-203	2197	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000146143's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03030	DNA replication	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000146143	Arteries	6.7250000E-005	-
ENSG00000146143	Ankle Brachial Index	3.4050031E-005	-
ENSG00000146143	Ankle Brachial Index	8.2186358E-005	-
ENSG00000146143	Ankle Brachial Index	3.7276687E-005	-
ENSG00000146143	Ankle Brachial Index	3.3854710E-005	-
ENSG00000146143	Ankle Brachial Index	1.9461675E-005	-
ENSG00000146143	25-Hydroxyvitamin D 2	4.3180000E-005	-
ENSG00000146143	Longevity	4E-6	27015805

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000146143	rs3800007	6	57372179	?	Parental extreme longevity (95 years and older)	27015805	[0.0071-0.0177] unit decrease	0.01239	EFO_0007796
ENSG00000146143	rs2013268	6	57404607	A	Red vs. brown/black hair color	30531825	NR	288.8	EFO_0003924
ENSG00000146143	rs9476035	6	57494269	?	Lung function (FEV1/FVC)	30595370			EFO_0004713

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000146143's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000082	G1/S transition of mitotic cell cycle	-	TAS	Process
GO:0003697	single-stranded DNA binding	21873635.	IBA	Function
GO:0003896	DNA primase activity	21873635.	IBA	Function
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005658	alpha DNA polymerase:primase complex	21873635.	IBA	Component
GO:0006269	DNA replication, synthesis of RNA primer	-	IEA	Process
GO:0006270	DNA replication initiation	-	TAS	Process
GO:0032201	telomere maintenance via semi-conservative replication	-	TAS	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0051539	4 iron, 4 sulfur cluster binding	-	IEA	Function

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.