EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28104536	Exome-Wide Association Study Identifies Low-Frequency Coding Variants in 2p23.2 and 7p11.2 Associated with Survival of Non-Small Cell Lung Cancer Patients.	J Thorac Oncol	2017 Apr	Zhu M	doi: 10.1016/j.jtho.2016.12.025

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr7	56058104	Splice_Site	novel	X242_splice	0.11
ACC	chr7	56060379	Missense_Mutation	novel	R392S	0.25
BLCA	chr7	56058085	Missense_Mutation	novel	S236L	0.21
BLCA	chr7	56058647	Missense_Mutation	NA	L305V	0.22
BLCA	chr7	56060570	Intron	novel		0.24
BLCA	chr7	56055630	Missense_Mutation	novel	H115Y	0.5
BLCA	chr7	56060570	Intron	novel		0.61
BLCA	chr7	56055658	Missense_Mutation	rs758284765	E124V	0.13
BRCA	chr7	56063092	3'UTR	novel		0.35
BRCA	chr7	56062757	Splice_Site	novel	X508_splice	0.21
BRCA	chr7	56060917	Missense_Mutation	rs770231271	D442N	0.29
BRCA	chr7	56060318	Missense_Mutation	NA	V372A	0.28
CESC	chr7	56056359	Missense_Mutation	novel	D187N	0.23
CESC	chr7	56054455	Silent	NA	V96V	0.13
CESC	chr7	56054499	Missense_Mutation	NA	S111C	0.13
CESC	chr7	56058503	Missense_Mutation	novel	F289L	0.12
CESC	chr7	56058505	In_Frame_Ins	novel	V290_V291insLRFNS	0.13
CESC	chr7	56058479	Silent	novel	V281V	0.2
CESC	chr7	56055448	Intron	NA		0.19
COAD	chr7	56055751	Missense_Mutation	NA	S155Y	0.45
COAD	chr7	56058028	Missense_Mutation	NA	R217Q	0.06
COAD	chr7	56058661	Silent	NA	G309G	0.17
COAD	chr7	56060903	Missense_Mutation	NA	V437A	0.3
COAD	chr7	56058450	Frame_Shift_Del	NA	I274*	0.21
COAD	chr7	56058378	Frame_Shift_Del	novel	*Y250Tfs11**	0.09
COAD	chr7	56060861	Missense_Mutation	NA	I423N	0.29
COAD	chr7	56058378	Frame_Shift_Del	novel	*Y250Tfs11**	0.45
COAD	chr7	56058658	Missense_Mutation	novel	E308D	0.05
COAD	chr7	56060896	Missense_Mutation	novel	L435I	0.05
COAD	chr7	56058408	Missense_Mutation	NA	K258Q	0.14
COAD	chr7	56060833	Missense_Mutation	novel	V414M	0.25
DLBC	chr7	56061761	Missense_Mutation	novel	N454K	0.24
ESCA	chr7	56051782	5'UTR	rs535381274		0.27
ESCA	chr7	56058039	Missense_Mutation	novel	M221L	0.54
GBM	chr7	56054496	Missense_Mutation	novel	I110S	0.1
HNSC	chr7	56061777	Nonsense_Mutation	novel	Q460*	0.17
HNSC	chr7	56060272	Missense_Mutation	novel	E357K	0.12
HNSC	chr7	56056359	Missense_Mutation	novel	D187H	0.11
HNSC	chr7	56062752	Missense_Mutation	novel	S507C	0.24
HNSC	chr7	56052446	Silent	novel	I54I	0.37
HNSC	chr7	56060891	Missense_Mutation	novel	A433V	0.34
KIRP	chr7	56060853	Silent	novel	E420E	0.61
KIRP	chr7	56063134	3'UTR	novel		0.34
KIRP	chr7	56062719	Missense_Mutation	novel	D496V	0.41
LGG	chr7	56060593	Intron	novel		0.06
LGG	chr7	56059611	Missense_Mutation	novel	H346Y	0.29
LIHC	chr7	56058093	Missense_Mutation	novel	Y239H	0.4
LIHC	chr7	56060273	Missense_Mutation	novel	E357G	0.42
LIHC	chr7	56051812	5'UTR	rs761665214		0.3
LIHC	chr7	56051837	5'UTR	novel		0.22
LIHC	chr7	56051838	5'UTR	novel		0.22
LUAD	chr7	56058698	Nonsense_Mutation	novel	E322*	0.25
LUAD	chr7	56058510	Missense_Mutation	NA	I292V	0.27
LUAD	chr7	56054461	Missense_Mutation	rs368822326	I98M	0.08
LUAD	chr7	56061822	Missense_Mutation	novel	Q475E	0.25
LUAD	chr7	56059608	Nonsense_Mutation	novel	G345*	0.2
LUAD	chr7	56056374	Missense_Mutation	NA	E192Q	0.04
LUAD	chr7	56058695	Missense_Mutation	novel	M321V	0.24
LUAD	chr7	56058061	Missense_Mutation	NA	A228V	0.45
LUAD	chr7	56058659	Missense_Mutation	novel	G309C	0.51
LUSC	chr7	56060827	Missense_Mutation	novel	G412C	0.42
LUSC	chr7	56054414	Missense_Mutation	NA	A83T	0.23
LUSC	chr7	56058450	Frame_Shift_Del	NA	I274*	0.16
LUSC	chr7	56054438	Missense_Mutation	novel	G91C	0.18
LUSC	chr7	56060495	Intron	novel		0.11
LUSC	chr7	56055678	Missense_Mutation	novel	L131V	0.64
LUSC	chr7	56058001	Missense_Mutation	novel	R208T	0.5
LUSC	chr7	56059556	Silent	NA	A327A	0.35
LUSC	chr7	56060383	Missense_Mutation	novel	G394C	0.46
LUSC	chr7	56058049	Missense_Mutation	NA	R224K	0.29
LUSC	chr7	56055690	Nonsense_Mutation	novel	E135*	0.16
PAAD	chr7	56058084	Missense_Mutation	novel	S236P	0.16
READ	chr7	56058450	Frame_Shift_Del	NA	I274*	0.22
READ	chr7	56058462	Nonsense_Mutation	NA	E276*	0.38
READ	chr7	56063183	3'UTR	novel		0.33
SKCM	chr7	56063052	Silent	rs374991164	I521I	0.37
SKCM	chr7	56060920	Frame_Shift_Ins	novel	*L444Ffs16**	0.27
SKCM	chr7	56054403	Missense_Mutation	novel	K79M	0.33
SKCM	chr7	56054404	Silent	novel	K79K	0.32
SKCM	chr7	56055657	Missense_Mutation	novel	E124K	0.08
SKCM	chr7	56055670	Frame_Shift_Del	novel	*K129Rfs11**	0.09
SKCM	chr7	56060537	Intron	novel		0.84
SKCM	chr7	56060818	Missense_Mutation	NA	P409S	0.26
SKCM	chr7	56054499	Missense_Mutation	rs758352451	S111F	0.29
STAD	chr7	56058421	Missense_Mutation	NA	A262V	0.09
STAD	chr7	56060527	Intron	novel		0.11
STAD	chr7	56058397	Frame_Shift_Ins	novel	*L259Nfs3**	0.19
STAD	chr7	56058377	Frame_Shift_Ins	NA	*Y250Lfs14**	0.35
STAD	chr7	56060474	Intron	novel		0.37
STAD	chr7	56061783	Missense_Mutation	novel	T462S	0.12
STAD	chr7	56060884	Missense_Mutation	NA	G431S	0.26
STAD	chr7	56063187	3'UTR	novel		0.35
STAD	chr7	56058377	Frame_Shift_Ins	NA	*Y250Lfs14**	0.17
STAD	chr7	56054416	Silent	novel	A83A	0.18
STAD	chr7	56055758	Silent	NA	R157R	0.17
STAD	chr7	56060916	Silent	NA	A441A	0.12
STAD	chr7	56054414	Missense_Mutation	NA	A83T	0.21
TGCT	chr7	56051961	Missense_Mutation	novel	L38Q	0.26
UCEC	chr7	56061758	Silent	rs7799515	Q453Q	0.18
UCEC	chr7	56063076	Silent	NA	L529L	0.11
UCEC	chr7	56061809	Missense_Mutation	novel	H470Q	0.23
UCEC	chr7	56055751	Missense_Mutation	novel	S155F	0.17
UCEC	chr7	56058080	Silent	rs567948145	N234N	0.34
UCEC	chr7	56058674	Missense_Mutation	novel	R314C	0.52
UCEC	chr7	56058044	Missense_Mutation	novel	K222N	0.08
UCEC	chr7	56054483	Missense_Mutation	novel	A106T	0.09
UCEC	chr7	56055766	Missense_Mutation	novel	V160A	0.03
UCEC	chr7	56060312	Missense_Mutation	rs764432664	R370H	0.24
UCEC	chr7	56063112	3'UTR	novel		0.21
UCEC	chr7	56058029	Silent	NA	R217R	0.48
UCEC	chr7	56051827	5'UTR	novel		0.21
UCEC	chr7	56063150	3'UTR	novel		0.42
UCEC	chr7	56058450	Frame_Shift_Del	NA	I274*	0.43
UCEC	chr7	56060312	Missense_Mutation	rs764432664	R370H	0.31
UCEC	chr7	56058447	Missense_Mutation	novel	V271I	0.46
UCEC	chr7	56054485	Silent	rs148293442	A106A	0.16
UCEC	chr7	56060926	Missense_Mutation	rs767086827	L445F	0.23
UCEC	chr7	56058377	Frame_Shift_Ins	NA	*Y250Lfs14**	0.34
UCEC	chr7	56058675	Missense_Mutation	NA	R314H	0.37
UCEC	chr7	56062717	Missense_Mutation	NA	W495C	0.18
UCEC	chr7	56055726	Missense_Mutation	novel	T147A	0.2
UCEC	chr7	56051934	Missense_Mutation	novel	G29D	0.34
UCEC	chr7	56051850	Translation_Start_Site	novel	M1?	0.47
UCEC	chr7	56058081	Missense_Mutation	NA	V235M	0.2
UCEC	chr7	56060275	Missense_Mutation	NA	E358Q	0.26
UCEC	chr7	56058450	Frame_Shift_Del	NA	I274*	0.45
UCEC	chr7	56058434	Missense_Mutation	novel	F266L	0.41
UCEC	chr7	56055723	Missense_Mutation	novel	E146K	0.26
UCEC	chr7	56058687	Missense_Mutation	novel	R318M	0.15
UCEC	chr7	56058450	Frame_Shift_Del	NA	I274*	0.2
UCEC	chr7	56058675	Missense_Mutation	NA	R314H	0.27
UCEC	chr7	56063119	3'UTR	novel		0.18

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
THCA	DEL	0	0.27619

Survival Analysis

Cancer	P-value	Q-value
SARC	0.016	Kaplan-Meier Survival Analysis
MESO	0.0029	Kaplan-Meier Survival Analysis
ACC	0.00028	Kaplan-Meier Survival Analysis
HNSC	0.0019	Kaplan-Meier Survival Analysis
LUSC	0.021	Kaplan-Meier Survival Analysis
BRCA	0.0059	Kaplan-Meier Survival Analysis
KIRP	0.0077	Kaplan-Meier Survival Analysis
PAAD	0.05	Kaplan-Meier Survival Analysis
BLCA	0.033	Kaplan-Meier Survival Analysis
CESC	0.0011	Kaplan-Meier Survival Analysis
READ	0.042	Kaplan-Meier Survival Analysis
KICH	0.0086	Kaplan-Meier Survival Analysis
LIHC	0.00012	Kaplan-Meier Survival Analysis
DLBC	0.037	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.0001	Kaplan-Meier Survival Analysis
OV	0.047	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000146731 (Gene tree)
Gene ID: 908
Gene Symbol: CCT6A
Alias: TTCP20|TCPZ|Cctz|HTR3|TCP20|CCT6
Full Name: chaperonin containing TCP1 subunit 6A
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 12,360 bases
Position: chr7:56,051,630-56,063,989
Accession: 1620
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, several pseudogenes of this gene have been located. [provided by RefSeq, Jun 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000492618	CCT6A-207	692	-	-	- (aa)	-	-
ENST00000462133	CCT6A-203	665	-	-	- (aa)	-	-
ENST00000335503	CCT6A-202	2529	-	ENSP00000352019	486 (aa)	-	P40227
ENST00000482776	CCT6A-206	765	-	-	- (aa)	-	-
ENST00000275603	CCT6A-201	2719	-	ENSP00000275603	531 (aa)	-	P40227
ENST00000493855	CCT6A-208	261	-	-	- (aa)	-	-
ENST00000466572	CCT6A-205	686	-	-	- (aa)	-	-
ENST00000466479	CCT6A-204	745	-	-	- (aa)	-	-
ENST00000494736	CCT6A-209	411	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000146731's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000146731	rs6593297	7	56054365	A	Systolic blood pressure	30224653	[0.1-0.21] mmHg increase	0.1581	EFO_0006335
ENSG00000146731	rs7793921	7	56053188	G	Plasma free amino acid levels (adjusted for twenty other PFAAs)	30659259	[0.22-0.3] unit decrease	0.26	EFO_0009774\|EFO_0005134
ENSG00000146731	rs7793921	7	56053188	G	Plasma free amino acid levels	30659259	[0.28-0.4] unit decrease	0.34	EFO_0009774\|EFO_0005134

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000146731's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005515	protein binding	14532270.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005737	cytoplasm	8034610.	TAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005832	chaperonin-containing T-complex	21873635.	IBA	Component
GO:0005832	chaperonin-containing T-complex	23011926.	IDA	Component
GO:0005832	chaperonin-containing T-complex	25467444.	TAS	Component
GO:0005874	microtubule	21525035.	IDA	Component
GO:0006457	protein folding	-	TAS	Process
GO:0032212	positive regulation of telomere maintenance via telomerase	25467444.	IMP	Process
GO:0050821	protein stabilization	25467444.	IMP	Process
GO:0051082	unfolded protein binding	-	IEA	Function
GO:0070062	extracellular exosome	19056867.20458337.23533145.	HDA	Component
GO:0071987	WD40-repeat domain binding	25467444.	IPI	Function
GO:1904851	positive regulation of establishment of protein localization to telomere	25467444.	IMP	Process
GO:1904871	positive regulation of protein localization to Cajal body	25467444.	HMP	Process
GO:1904874	positive regulation of telomerase RNA localization to Cajal body	25467444.	HMP	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

GWAS

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.