EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr7	158656355	Missense_Mutation	novel	E765K	0.28
BLCA	chr7	158664600	Missense_Mutation	novel	V544M	0.34
BLCA	chr7	158644373	Nonsense_Mutation	NA	S1099*	0.12
BLCA	chr7	158631668	Nonstop_Mutation	novel	1144Eext14	0.25
BLCA	chr7	158650874	Frame_Shift_Del	novel	*V1007Sfs8**	0.38
BLCA	chr7	158664199	Silent	NA	E600E	0.11
BLCA	chr7	158631616	3'UTR	novel		0.19
BRCA	chr7	158701897	Translation_Start_Site	novel	M1?	0.19
BRCA	chr7	158631497	3'UTR	novel		0.07
BRCA	chr7	158680718	Splice_Region	novel		0.43
BRCA	chr7	158656596	Missense_Mutation	NA	E724K	0.12
BRCA	chr7	158655222	Missense_Mutation	NA	E848K	0.21
BRCA	chr7	158693448	Nonsense_Mutation	NA	S43*	0.17
BRCA	chr7	158664552	Missense_Mutation	NA	E560K	0.21
CESC	chr7	158652479	Splice_Region	novel	V916V	0.08
CESC	chr7	158683347	Missense_Mutation	rs747423439	G293R	0.36
CESC	chr7	158671601	Silent	NA	L464L	0.29
CESC	chr7	158654725	Intron	novel		0.22
CESC	chr7	158631448	3'UTR	novel		0.7
CESC	chr7	158652294	Missense_Mutation	rs201551364	R978Q	0.39
CESC	chr7	158658401	Missense_Mutation	rs370630902	R666H	0.18
CESC	chr7	158689928	Missense_Mutation	rs371198970	R188H	0.43
CESC	chr7	158686184	Silent	novel	G275G	0.3
COAD	chr7	158675564	Silent	rs370565592	P413P	0.44
COAD	chr7	158680742	Silent	novel	P333P	0.06
COAD	chr7	158671578	Missense_Mutation	rs199662183	S472L	0.14
COAD	chr7	158692949	Missense_Mutation	novel	S92N	0.26
COAD	chr7	158646515	Missense_Mutation	novel	P1042S	0.19
COAD	chr7	158680022	Missense_Mutation	novel	D362Y	0.07
COAD	chr7	158664558	Missense_Mutation	novel	A558T	0.33
COAD	chr7	158664713	Missense_Mutation	rs753719449	R506H	0.34
COAD	chr7	158680720	Splice_Site	NA	X340_splice	0.31
COAD	chr7	158652328	Missense_Mutation	rs377006246	R967W	0.38
COAD	chr7	158662313	Nonsense_Mutation	novel	E624*	0.22
COAD	chr7	158692919	Missense_Mutation	NA	V102A	0.18
COAD	chr7	158693411	Missense_Mutation	rs547669473	K55N	0.2
ESCA	chr7	158655452	Missense_Mutation	novel	D798Y	0.37
ESCA	chr7	158690693	Nonsense_Mutation	novel	R138*	0.35
GBM	chr7	158671581	Missense_Mutation	novel	N471T	0.23
GBM	chr7	158664630	Missense_Mutation	novel	E534K	0.26
GBM	chr7	158654649	Missense_Mutation	NA	D898Y	0.14
GBM	chr7	158654770	Intron	novel		0.12
GBM	chr7	158656325	Missense_Mutation	novel	E775K	0.2
GBM	chr7	158675595	Missense_Mutation	novel	I403T	0.09
GBM	chr7	158689869	Missense_Mutation	novel	D208Y	0.31
GBM	chr7	158690722	Missense_Mutation	novel	G128V	0.06
GBM	chr7	158655168	Missense_Mutation	novel	E866K	0.37
GBM	chr7	158680783	Missense_Mutation	rs201348020	R320W	0.21
HNSC	chr7	158679968	Missense_Mutation	novel	E380K	0.11
HNSC	chr7	158683350	Missense_Mutation	novel	H292Y	0.13
HNSC	chr7	158656558	Silent	novel	Q736Q	0.11
HNSC	chr7	158662208	Silent	novel	L659L	0.25
KIRC	chr7	158654619	Silent	NA	R908R	0.23
KIRC	chr7	158679997	Missense_Mutation	NA	M370R	0.39
KIRC	chr7	158654629	Silent	rs752571821	Q904Q	0.19
KIRC	chr7	158664747	Frame_Shift_Del	novel	*W495Gfs25**	0.14
KIRC	chr7	158654746	Intron	novel		0.26
KIRC	chr7	158690663	Missense_Mutation	NA	C148S	0.06
KIRC	chr7	158656560	Frame_Shift_Ins	novel	*Q736Tfs12**	0.06
LAML	chr7	158631676	Frame_Shift_Del	novel	L1141*	0.22
LAML	chr7	158664186	Frame_Shift_Del	novel	*T605Lfs9**	0.05
LGG	chr7	158654737	Intron	novel		0.06
LGG	chr7	158650966	Missense_Mutation	novel	Y981H	0.06
LIHC	chr7	158644365	Missense_Mutation	NA	R1102G	0.23
LIHC	chr7	158656357	Missense_Mutation	novel	I764T	0.26
LIHC	chr7	158631656	3'UTR	novel		0.06
LUAD	chr7	158646523	Missense_Mutation	novel	S1039F	0.05
LUAD	chr7	158675647	Nonsense_Mutation	NA	E386*	0.23
LUAD	chr7	158689954	Splice_Site	novel	X180_splice	0.22
LUAD	chr7	158631660	3'UTR	rs755725541		0.19
LUAD	chr7	158652292	Splice_Site	novel	X978_splice	0.16
LUAD	chr7	158652294	Missense_Mutation	novel	R978L	0.16
LUAD	chr7	158655417	Missense_Mutation	novel	K809N	0.27
LUAD	chr7	158631520	3'UTR	novel		0.21
LUAD	chr7	158658338	Missense_Mutation	novel	S687I	0.13
LUAD	chr7	158664237	Missense_Mutation	novel	E588Q	0.18
LUAD	chr7	158656329	Silent	novel	N773N	0.21
LUAD	chr7	158662328	Missense_Mutation	NA	M619V	0.12
LUAD	chr7	158690670	Silent	NA	Q145Q	0.17
LUAD	chr7	158675633	Silent	NA	P390P	0.15
LUAD	chr7	158656362	Silent	NA	V762V	0.12
LUAD	chr7	158654673	Missense_Mutation	NA	D890H	0.15
LUAD	chr7	158675616	Missense_Mutation	novel	G396V	0.21
LUSC	chr7	158656417	Missense_Mutation	NA	K744I	0.17
LUSC	chr7	158654789	Intron	novel		0.33
LUSC	chr7	158645562	Silent	NA	V1079V	0.3
LUSC	chr7	158671547	Missense_Mutation	NA	M482I	0.19
LUSC	chr7	158664595	Missense_Mutation	novel	Q545H	0.32
LUSC	chr7	158662348	Missense_Mutation	NA	S612L	0.12
LUSC	chr7	158687403	In_Frame_Del	novel	I237del	0.23
LUSC	chr7	158652482	Splice_Site	novel	X916_splice	0.12
LUSC	chr7	158701883	Missense_Mutation	novel	T6K	0.27
LUSC	chr7	158664683	Missense_Mutation	rs774500092	R516Q	0.07
LUSC	chr7	158664574	Missense_Mutation	novel	R552S	0.23
LUSC	chr7	158662292	Missense_Mutation	novel	K631E	0.35
LUSC	chr7	158671562	Silent	NA	V477V	0.23
LUSC	chr7	158656358	Missense_Mutation	novel	I764V	0.14
LUSC	chr7	158692956	Nonsense_Mutation	novel	R90*	0.17
LUSC	chr7	158690617	Missense_Mutation	novel	G163V	0.24
LUSC	chr7	158652403	Missense_Mutation	NA	D942Y	0.07
OV	chr7	158650879	Missense_Mutation	novel	T1010P	0.1
OV	chr7	158680040	Frame_Shift_Ins	novel	*E356Kfs40**	0.05
OV	chr7	158654779	Intron	novel		0.11
OV	chr7	158680043	Missense_Mutation	NA	V355I	0.61
OV	chr7	158656572	Frame_Shift_Ins	novel	*T732Lfs38**	0.24
OV	chr7	158652309	Frame_Shift_Ins	novel	*P973Qfs26**	0.03
OV	chr7	158683357	Silent	NA	F289F	0.27
OV	chr7	158650893	Frame_Shift_Del	novel	*H1004Rfs7**	0.31
PAAD	chr7	158631519	3'UTR	novel		0.15
PAAD	chr7	158655360	Silent	rs781659252	L828L	0.16
PAAD	chr7	158664631	Missense_Mutation	novel	E533D	0.16
PAAD	chr7	158680783	Missense_Mutation	rs201348020	R320W	0.07
PRAD	chr7	158650924	Nonsense_Mutation	NA	Q995*	0.11
PRAD	chr7	158658407	Missense_Mutation	NA	D664V	0.31
READ	chr7	158631497	3'UTR	novel		0.08
READ	chr7	158689824	Nonsense_Mutation	NA	E223*	0.41
SARC	chr7	158693477	Silent	rs765968854	F33F	0.21
SARC	chr7	158683334	Missense_Mutation	novel	P297L	0.23
SKCM	chr7	158631718	Splice_Site	novel	X1127_splice	0.25
SKCM	chr7	158683365	Nonsense_Mutation	novel	Q287*	0.4
SKCM	chr7	158655413	Missense_Mutation	rs369184720	R811C	0.25
SKCM	chr7	158675641	Missense_Mutation	novel	P388S	0.3
SKCM	chr7	158680067	Nonsense_Mutation	NA	R347*	0.13
SKCM	chr7	158664273	Missense_Mutation	NA	H576Y	0.92
SKCM	chr7	158631556	3'UTR	novel		0.22
SKCM	chr7	158646534	Silent	novel	P1035P	0.35
SKCM	chr7	158664656	Missense_Mutation	NA	S525F	0.05
SKCM	chr7	158650911	Missense_Mutation	novel	T999I	0.49
SKCM	chr7	158650912	Missense_Mutation	novel	T999S	0.49
SKCM	chr7	158679987	Missense_Mutation	novel	E373D	0.45
SKCM	chr7	158646540	Silent	NA	T1033T	0.13
SKCM	chr7	158654741	Intron	novel		0.27
SKCM	chr7	158656307	Missense_Mutation	novel	P781S	0.23
SKCM	chr7	158664230	Missense_Mutation	NA	P590L	0.47
SKCM	chr7	158701853	Missense_Mutation	NA	V16A	0.08
SKCM	chr7	158664276	Missense_Mutation	rs373939140	R575C	0.45
SKCM	chr7	158693473	Silent	NA	L35L	0.2
SKCM	chr7	158680789	Missense_Mutation	NA	K318E	0.31
SKCM	chr7	158662247	Missense_Mutation	novel	Y646H	0.44
STAD	chr7	158656286	Missense_Mutation	novel	L788F	0.14
STAD	chr7	158693415	Missense_Mutation	NA	L54P	0.05
STAD	chr7	158680006	Missense_Mutation	NA	A367V	0.31
STAD	chr7	158652294	Missense_Mutation	rs201551364	R978Q	0.1
STAD	chr7	158690662	Missense_Mutation	NA	C148Y	0.19
STAD	chr7	158644325	Missense_Mutation	NA	F1115C	0.29
STAD	chr7	158664274	Silent	NA	R575R	0.29
STAD	chr7	158655212	Missense_Mutation	novel	G851D	0.37
STAD	chr7	158655123	Missense_Mutation	NA	I881V	0.07
STAD	chr7	158652466	Frame_Shift_Del	NA	*Y921Mfs9**	0.16
STAD	chr7	158687383	Silent	rs372309426	H244H	0.19
STAD	chr7	158683348	Silent	NA	H292H	0.07
STAD	chr7	158650915	Missense_Mutation	NA	H998Y	0.16
STAD	chr7	158654618	Missense_Mutation	rs186888334	R908Q	0.21
STAD	chr7	158655420	Silent	rs527387542	G808G	0.42
STAD	chr7	158654769	Intron	novel		0.17
STAD	chr7	158679974	Missense_Mutation	NA	F378L	0.18
THCA	chr7	158686219	Missense_Mutation	NA	E264Q	0.35
UCEC	chr7	158631471	3'UTR	rs533739991		0.56
UCEC	chr7	158693411	Silent	NA	K55K	0.33
UCEC	chr7	158664543	Missense_Mutation	novel	A563S	0.42
UCEC	chr7	158645598	Missense_Mutation	novel	K1067N	0.18
UCEC	chr7	158664264	Missense_Mutation	novel	N579H	0.36
UCEC	chr7	158664656	Missense_Mutation	novel	S525Y	0.23
UCEC	chr7	158680745	Missense_Mutation	novel	K332N	0.39
UCEC	chr7	158690637	Silent	novel	L156L	0.39
UCEC	chr7	158664552	Missense_Mutation	NA	E560K	0.49
UCEC	chr7	158693431	Nonsense_Mutation	novel	E49*	0.42
UCEC	chr7	158693368	Missense_Mutation	novel	W70R	0.19
UCEC	chr7	158656325	Missense_Mutation	novel	E775K	0.29
UCEC	chr7	158693411	Missense_Mutation	rs547669473	K55N	0.24
UCEC	chr7	158631482	3'UTR	novel		0.24
UCEC	chr7	158693470	Missense_Mutation	NA	N36H	0.13
UCEC	chr7	158652295	Missense_Mutation	novel	R978W	0.58
UCEC	chr7	158689951	Splice_Region	NA	G180G	0.48
UCEC	chr7	158631519	3'UTR	novel		0.22
UCEC	chr7	158675510	Silent	rs377533159	T431T	0.46
UCEC	chr7	158652416	Missense_Mutation	novel	L937F	0.43
UCEC	chr7	158683374	Missense_Mutation	novel	D284Y	0.32
UCEC	chr7	158662340	Missense_Mutation	rs755516454	D615N	0.47
UCEC	chr7	158680790	Missense_Mutation	novel	K317N	0.31
UCEC	chr7	158631626	3'UTR	novel		0.27
UCEC	chr7	158656304	Missense_Mutation	rs201255175	R782W	0.3
UCEC	chr7	158690693	Nonsense_Mutation	novel	R138*	0.34
UCEC	chr7	158644379	Missense_Mutation	rs186267236	K1097T	0.33
UCEC	chr7	158658359	Missense_Mutation	NA	A680D	0.38
UCEC	chr7	158693330	Missense_Mutation	rs778406650	E82D	0.57
UCEC	chr7	158652384	Missense_Mutation	novel	A948V	0.57
UCEC	chr7	158671577	Silent	rs144031410	S472S	0.27
UCEC	chr7	158631587	3'UTR	novel		0.36
UCEC	chr7	158664620	Missense_Mutation	NA	C537Y	0.09
UCEC	chr7	158693438	Missense_Mutation	novel	Q46H	0.19
UCEC	chr7	158664552	Missense_Mutation	NA	E560K	0.4
UCEC	chr7	158687435	Missense_Mutation	novel	R227K	0.29
UCEC	chr7	158656404	Missense_Mutation	novel	Q748H	0.14
UCEC	chr7	158675657	Splice_Site	NA	X383_splice	0.43
UCEC	chr7	158683348	Silent	NA	H292H	0.34
UCEC	chr7	158680782	Missense_Mutation	rs756707913	R320Q	0.55
UCEC	chr7	158650953	Missense_Mutation	NA	R985M	0.2
UCEC	chr7	158679967	Missense_Mutation	novel	E380A	0.14
UCEC	chr7	158664680	Missense_Mutation	NA	R517H	0.36
UCEC	chr7	158689945	Silent	rs781578992	D182D	0.36
UCEC	chr7	158650837	Missense_Mutation	rs373650801	R1024W	0.37
UCEC	chr7	158671586	Silent	rs772140188	H469H	0.54
UCEC	chr7	158652466	Frame_Shift_Del	NA	*Y921Mfs9**	0.38
UCEC	chr7	158679981	Missense_Mutation	NA	Q375H	0.43
UCEC	chr7	158645564	Missense_Mutation	novel	V1079M	0.35
UCEC	chr7	158655440	Missense_Mutation	NA	L802I	0.5
UCEC	chr7	158644360	Silent	NA	E1103E	0.26
UCEC	chr7	158631515	3'UTR	novel		0.11
UCEC	chr7	158689878	Nonsense_Mutation	novel	E205*	0.48
UCEC	chr7	158690720	In_Frame_Ins	novel	G128_I129insLREIVSP	0.08
UCEC	chr7	158644303	Missense_Mutation	novel	E1122D	0.22
UCEC	chr7	158650915	Missense_Mutation	NA	H998Y	0.23
UCEC	chr7	158652339	Missense_Mutation	novel	E963A	0.38
UCEC	chr7	158680738	Missense_Mutation	novel	L335I	0.29
UCEC	chr7	158671655	Missense_Mutation	novel	M446I	0.39
UCEC	chr7	158692843	Splice_Region	rs766552957	N127N	0.38
UCEC	chr7	158644377	Missense_Mutation	novel	S1098G	0.04
UCEC	chr7	158664275	Missense_Mutation	novel	R575H	0.06
UCEC	chr7	158675657	Splice_Site	NA	X383_splice	0.12
UCEC	chr7	158664641	Missense_Mutation	novel	N530T	0.38
UCEC	chr7	158689825	Missense_Mutation	novel	K222N	0.28
UCEC	chr7	158692875	Missense_Mutation	novel	E117K	0.33
UCS	chr7	158675492	Silent	novel	R437R	0.35

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1	0.12261
BLCA	DEL	0.1176	0.062073
CESC	DEL	0.1763	0.0016147
DLBC	DEL	0.0833	0.03486
KIRC	AMP	0.2917	0.075418
LAML	DEL	0.1309	3.4101e-05
LGG	AMP	0.2982	1.5525e-07
LIHC	DEL	0.0811	0.24831
LUSC	DEL	0.1597	3.2062e-06
OV	AMP	0.4922	1.5763e-13
PAAD	DEL	0.0652	0.049388
SARC	DEL	0.2412	2.9687e-06
TGCT	DEL	0.0733	0.11738
THCA	DEL	0	0.27619
UCEC	DEL	0.0965	0.0001859
UCS	DEL	0.3393	0.10142

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0025	Kaplan-Meier Survival Analysis
STAD	0.017	Kaplan-Meier Survival Analysis
MESO	0.00012	Kaplan-Meier Survival Analysis
ACC	0.0001	Kaplan-Meier Survival Analysis
HNSC	0.0082	Kaplan-Meier Survival Analysis
SKCM	0.00025	Kaplan-Meier Survival Analysis
KIRP	0.00011	Kaplan-Meier Survival Analysis
PAAD	0.0022	Kaplan-Meier Survival Analysis
READ	0.049	Kaplan-Meier Survival Analysis
KICH	0.00012	Kaplan-Meier Survival Analysis
UCEC	0.0027	Kaplan-Meier Survival Analysis
LIHC	0.00018	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.00015	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000146918 (Gene tree)
Gene ID: 54892
Gene Symbol: NCAPG2
Alias: FLJ20311|MTB|CAP-G2|hCAP-G2|LUZP5
Full Name: non-SMC condensin II complex subunit G2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 73,663 bases
Position: chr7:158,631,169-158,704,831
Accession: 21904
RBP type: non-canonical RBP
Summary: This gene encodes a protein that belongs to the Condensin2nSMC family of proteins. The encoded protein is a regulatory subunit of the condensin II complex which, along with the condensin I complex, plays a role in chromosome assembly and segregation during mitosis. A similar protein in mouse is required for early development of the embryo. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000409423	NCAPG2-203	3957	-	ENSP00000386569	1143 (aa)	-	Q86XI2
ENST00000472591	NCAPG2-207	554	-	-	- (aa)	-	-
ENST00000432615	NCAPG2-204	4134	-	ENSP00000414337	389 (aa)	-	F8WE06
ENST00000474940	NCAPG2-208	583	-	-	- (aa)	-	-
ENST00000475918	NCAPG2-209	557	-	-	- (aa)	-	-
ENST00000491792	NCAPG2-210	581	-	-	- (aa)	-	-
ENST00000409339	NCAPG2-202	5253	XM_011516356	ENSP00000387007	1156 (aa)	XP_011514658	Q86XI2
ENST00000467785	NCAPG2-206	3276	-	-	- (aa)	-	-
ENST00000441982	NCAPG2-205	2926	XM_011516362	ENSP00000408080	898 (aa)	XP_011514664	H0Y6U5
ENST00000621338	NCAPG2-211	597	-	-	- (aa)	-	-
ENST00000356309	NCAPG2-201	3930	XM_005249547	ENSP00000348657	1143 (aa)	XP_005249604	Q86XI2

Gene Model

Click here to download ENSG00000146918's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000146918's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000796	condensin complex	-	IEA	Component
GO:0001833	inner cell mass cell proliferation	-	IEA	Process
GO:0005515	protein binding	17268547.	IPI	Function
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006366	transcription by RNA polymerase II	-	IEA	Process
GO:0007049	cell cycle	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016607	nuclear speck	-	IDA	Component
GO:0030218	erythrocyte differentiation	-	IEA	Process
GO:0030261	chromosome condensation	-	IEA	Process
GO:0035064	methylated histone binding	20622854.	IDA	Function
GO:0043425	bHLH transcription factor binding	-	IEA	Function
GO:0045647	negative regulation of erythrocyte differentiation	-	IEA	Process
GO:0051301	cell division	-	IEA	Process
GO:0061098	positive regulation of protein tyrosine kinase activity	-	IEA	Process
GO:0098772	molecular function regulator	-	IEA	Function
GO:2000273	positive regulation of signaling receptor activity	-	IEA	Process

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.