EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
17965020	The PSF.p54nrb complex is a novel Mnk substrate that binds the mRNA for tumor necrosis factor alpha.	J Biol Chem	2008 Jan 4	Buxad?? M	-
26148231	p54(nrb)/NONO regulates lipid metabolism and breast cancer growth through SREBP-1A.	Oncogene	2016 Mar 17	Zhu Z	doi: 10.1038/onc.2015.197
27297086	Study on the expression of PAK4 and P54 protein in breast cancer.	World J Surg Oncol	2016 Jun 13	Bi Y	doi: 10.1186/s12957-016-0913-6.
27259250	Long noncoding RNA GAPLINC promotes invasion in colorectal cancer by targeting SNAI2 through binding with PSF and NONO.	Oncotarget	2016 Jul 5	Yang P	doi: 10.18632/oncotarget.9741.
29773901	Ets-1 promoter-associated noncoding RNA regulates the NONO/ERG/Ets-1 axis to drive gastric cancer progression.	Oncogene	2018 Aug	Li D	doi: 10.1038/s41388-018-0302-4

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chrX	71294222	Splice_Region	novel		0.68
BLCA	chrX	71294297	Missense_Mutation	novel	R140L	0.27
BLCA	chrX	71290665	Missense_Mutation	novel	E10Q	0.81
BRCA	chrX	71297015	Missense_Mutation	NA	R304H	0.41
BRCA	chrX	71297888	Missense_Mutation	NA	E361K	0.42
BRCA	chrX	71283687	5'UTR	novel		0.29
BRCA	chrX	71291916	Missense_Mutation	novel	G98R	0.3	RRM_1
BRCA	chrX	71300162	3'UTR	novel		0.4
CESC	chrX	71301041	3'UTR	novel		0.25
CESC	chrX	71301157	3'UTR	novel		0.29
CESC	chrX	71301066	3'UTR	novel		0.61
CESC	chrX	71294469	Silent	novel	G197G	0.12
CESC	chrX	71283625	5'UTR	novel		0.3
CESC	chrX	71294216	Intron	novel		0.31
CESC	chrX	71297430	Nonsense_Mutation	NA	E333*	0.67
CESC	chrX	71301028	3'UTR	novel		0.21
CESC	chrX	71296608	Missense_Mutation	NA	D232H	0.25
CESC	chrX	71301055	3'UTR	novel		0.31
CESC	chrX	71301102	3'UTR	novel		0.25
CESC	chrX	71294401	Missense_Mutation	novel	E175Q	0.2
CESC	chrX	71291889	Missense_Mutation	novel	E89K	0.23	RRM_1
CESC	chrX	71301083	3'UTR	NA		0.8
CHOL	chrX	71296599	Nonsense_Mutation	novel	Q229*	0.42
CHOL	chrX	71301112	3'UTR	novel		0.21
COAD	chrX	71297388	Missense_Mutation	NA	R319C	0.3
COAD	chrX	71294362	Missense_Mutation	NA	E162K	0.63
COAD	chrX	71296871	Missense_Mutation	NA	R256I	0.14
COAD	chrX	71294440	Missense_Mutation	NA	S188P	0.9
COAD	chrX	71290652	Missense_Mutation	novel	K5N	0.14
COAD	chrX	71294234	Missense_Mutation	NA	R119Q	0.5
COAD	chrX	71294296	Missense_Mutation	NA	R140C	0.35
COAD	chrX	71297933	Missense_Mutation	NA	D376Y	0.09
COAD	chrX	71297934	Missense_Mutation	NA	D376V	0.09
COAD	chrX	71297900	Nonsense_Mutation	NA	R365*	0.15
DLBC	chrX	71296939	Frame_Shift_Del	novel	*K279Sfs33**	0.05
DLBC	chrX	71296646	Missense_Mutation	rs759584441	N244K	0.28
ESCA	chrX	71283561	5'Flank	novel		0.53
GBM	chrX	71297897	Missense_Mutation	NA	R364W	0.45
GBM	chrX	71294361	Missense_Mutation	novel	N161K	0.1
GBM	chrX	71296951	Frame_Shift_Ins	novel	*D283Afs12**	0.26
GBM	chrX	71296855	Nonsense_Mutation	NA	R251*	0.38
GBM	chrX	71296599	Missense_Mutation	novel	Q229K	0.35
GBM	chrX	71300066	Missense_Mutation	novel	R469H	0.38
HNSC	chrX	71294347	Nonsense_Mutation	novel	Q157*	0.31
HNSC	chrX	71294513	Missense_Mutation	novel	S212F	0.46
HNSC	chrX	71300218	3'UTR	novel		0.22
HNSC	chrX	71297898	Missense_Mutation	rs779961109	R364Q	0.31
HNSC	chrX	71294501	Missense_Mutation	novel	C208Y	0.54
KIRC	chrX	71291893	Missense_Mutation	NA	M90R	0.13	RRM_1
KIRC	chrX	71296899	Nonsense_Mutation	NA	Y265*	0.5
KIRC	chrX	71298800	In_Frame_Del	novel	D422_T424delinsA	0.46
LGG	chrX	71300026	Missense_Mutation	rs375259906	R456C	0.4
LGG	chrX	71294440	Missense_Mutation	NA	S188P	0.29
LUAD	chrX	71297891	Missense_Mutation	NA	M362L	0.1
LUAD	chrX	71290665	Nonsense_Mutation	novel	E10*	0.35
LUAD	chrX	71294445	Frame_Shift_Del	novel	*G191Afs25**	0.54
LUAD	chrX	71300137	3'UTR	novel		0.35
LUAD	chrX	71291841	Nonsense_Mutation	NA	R73*	0.11
LUSC	chrX	71294458	Missense_Mutation	novel	E194Q	0.11
LUSC	chrX	71291964	Missense_Mutation	NA	I114L	0.19
OV	chrX	71300002	Missense_Mutation	NA	G448C	0.47
OV	chrX	71294515	Missense_Mutation	NA	F213L	0.15
OV	chrX	71291903	Silent	NA	L93L	0.47
OV	chrX	71299996	Missense_Mutation	novel	A446S	0.09
PAAD	chrX	71297897	Missense_Mutation	NA	R364W	0.04
PAAD	chrX	71300062	Missense_Mutation	novel	R468C	0.06
PRAD	chrX	71296573	Missense_Mutation	NA	R220H	0.8
PRAD	chrX	71300062	Missense_Mutation	novel	R468C	0.24
READ	chrX	71298734	Missense_Mutation	NA	A400V	0.92
SARC	chrX	71300241	3'UTR	novel		0.56
SKCM	chrX	71291940	Missense_Mutation	NA	H106Y	0.85
SKCM	chrX	71300116	3'UTR	novel		0.58
SKCM	chrX	71294302	Missense_Mutation	novel	R142C	0.12
SKCM	chrX	71296999	Missense_Mutation	novel	E299K	0.24
SKCM	chrX	71294362	Missense_Mutation	NA	E162K	0.18
SKCM	chrX	71291847	Missense_Mutation	NA	R75C	0.35
SKCM	chrX	71294309	Missense_Mutation	NA	A144V	0.16
SKCM	chrX	71291940	Missense_Mutation	NA	H106Y	1
SKCM	chrX	71296889	Missense_Mutation	NA	S262F	0.45
SKCM	chrX	71300067	Silent	novel	R469R	0.61
SKCM	chrX	71298802	Missense_Mutation	NA	G423R	0.24
SKCM	chrX	71299988	Missense_Mutation	NA	G443E	0.44
SKCM	chrX	71294429	Missense_Mutation	NA	R184L	0.34
SKCM	chrX	71291953	Missense_Mutation	NA	G110E	0.71
SKCM	chrX	71300011	Missense_Mutation	rs776530967	P451S	0.13
SKCM	chrX	71294238	Silent	NA	T120T	0.38
SKCM	chrX	71291940	Missense_Mutation	NA	H106Y	0.42
SKCM	chrX	71291868	Missense_Mutation	NA	P82S	0.19	RRM_1
SKCM	chrX	71291953	Missense_Mutation	NA	G110E	0.29
SKCM	chrX	71294429	Missense_Mutation	NA	R184L	0.84
SKCM	chrX	71296591	Missense_Mutation	NA	P226L	1
STAD	chrX	71296913	Missense_Mutation	NA	R270H	0.33
STAD	chrX	71299945	Missense_Mutation	novel	P429T	0.19
STAD	chrX	71297900	Nonsense_Mutation	NA	R365*	0.41
STAD	chrX	71298739	Frame_Shift_Del	rs751687046	*P403Lfs17**	0.27
THCA	chrX	71291885	Silent	novel	E87E	0.1
UCEC	chrX	71291928	Missense_Mutation	NA	E102K	0.37
UCEC	chrX	71291842	Missense_Mutation	NA	R73Q	0.2
UCEC	chrX	71294297	Missense_Mutation	NA	R140H	0.32
UCEC	chrX	71297900	Nonsense_Mutation	NA	R365*	0.37
UCEC	chrX	71300286	3'UTR	novel		0.32
UCEC	chrX	71300744	3'UTR	novel		0.14
UCEC	chrX	71294403	Silent	NA	E175E	0.37
UCEC	chrX	71290700	Silent	novel	Q21Q	0.26
UCEC	chrX	71300062	Missense_Mutation	novel	R468C	0.34
UCEC	chrX	71294281	Missense_Mutation	novel	R135C	0.12
UCEC	chrX	71294463	Missense_Mutation	NA	F195L	0.41
UCEC	chrX	71297901	Missense_Mutation	NA	R365Q	0.43
UCEC	chrX	71283620	5'UTR	novel		0.37
UCEC	chrX	71291874	Missense_Mutation	novel	D84N	0.38	RRM_1
UCEC	chrX	71300260	3'UTR	novel		0.63
UCEC	chrX	71299951	Missense_Mutation	novel	T431P	0.41
UCEC	chrX	71294529	Splice_Site	NA	X217_splice	0.16
UCEC	chrX	71290667	Missense_Mutation	NA	E10D	0.48
UCEC	chrX	71294336	Missense_Mutation	NA	R153Q	0.45
UCEC	chrX	71294506	Nonsense_Mutation	novel	E210*	0.12
UCEC	chrX	71294280	Silent	novel	L134L	0.23
UCEC	chrX	71297850	Missense_Mutation	novel	R348H	0.23
UCEC	chrX	71294463	Missense_Mutation	NA	F195L	0.26
UCEC	chrX	71294335	Nonsense_Mutation	NA	R153*	0.45
UCEC	chrX	71294335	Nonsense_Mutation	NA	R153*	0.43
UCEC	chrX	71294482	Missense_Mutation	rs765426077	R202W	0.35
UCEC	chrX	71300158	3'UTR	novel		0.29
UCEC	chrX	71299993	Missense_Mutation	novel	G445R	0.41
UCEC	chrX	71300313	3'UTR	novel		0.27
UCEC	chrX	71300832	3'UTR	novel		0.32
UCEC	chrX	71300088	3'UTR	novel		0.18
UCEC	chrX	71297407	Missense_Mutation	novel	R325M	0.47
UCEC	chrX	71300774	3'UTR	novel		0.5
UCEC	chrX	71301055	3'UTR	novel		0.38
UCEC	chrX	71300155	3'UTR	novel		0.46
UCEC	chrX	71283589	5'UTR	novel		0.48
UCEC	chrX	71300980	3'UTR	novel		0.43
UCEC	chrX	71300062	Missense_Mutation	novel	R468C	0.11
UCEC	chrX	71290777	Missense_Mutation	novel	Q47P	0.48
UCEC	chrX	71300857	3'UTR	NA		0.82
UCEC	chrX	71291928	Missense_Mutation	NA	E102K	0.43
UCEC	chrX	71296579	Missense_Mutation	NA	V222G	0.23
UCEC	chrX	71300857	3'UTR	NA		0.48
UCEC	chrX	71297404	Missense_Mutation	rs749334644	R324Q	0.6
UCEC	chrX	71294335	Nonsense_Mutation	NA	R153*	0.36
UCEC	chrX	71300857	3'UTR	NA		0.35
UCEC	chrX	71291874	Missense_Mutation	novel	D84N	0.16	RRM_1
UCEC	chrX	71294257	Missense_Mutation	novel	V127L	0.22
UCEC	chrX	71297856	Missense_Mutation	rs757029715	R350H	0.16
UCEC	chrX	71294362	Missense_Mutation	NA	E162K	0.4
UCEC	chrX	71294480	Missense_Mutation	novel	A201V	0.31
UCEC	chrX	71300857	3'UTR	NA		0.26
UCEC	chrX	71296628	Missense_Mutation	novel	E238D	0.34
UCEC	chrX	71300260	3'UTR	novel		0.19
UCEC	chrX	71283650	5'UTR	novel		0.24
UCEC	chrX	71291784	Missense_Mutation	novel	G54C	0.29
UCEC	chrX	71294244	Silent	rs779757828	A122A	0.4
UCEC	chrX	71300858	3'UTR	novel		0.41
UCEC	chrX	71301147	3'UTR	novel		0.54
UCEC	chrX	71297917	Missense_Mutation	NA	F370L	0.63
UCEC	chrX	71300003	Missense_Mutation	novel	G448D	0.28
UCEC	chrX	71301028	3'UTR	novel		0.12
UCEC	chrX	71301148	3'UTR	novel		0.3
UCEC	chrX	71294355	Silent	NA	V159V	0.33
UCEC	chrX	71296982	Missense_Mutation	NA	R293H	0.22
UCEC	chrX	71296577	Silent	NA	P221P	0.17
UCEC	chrX	71300857	3'UTR	NA		0.42
UCEC	chrX	71291968	Missense_Mutation	NA	R115H	0.33
UCEC	chrX	71297919	Missense_Mutation	novel	K371R	0.12
UCEC	chrX	71294362	Missense_Mutation	NA	E162K	0.05
UCEC	chrX	71296572	Missense_Mutation	novel	R220C	0.33
UCEC	chrX	71283705	5'UTR	novel		0.36
UCEC	chrX	71294218	Intron	novel		0.36
UCEC	chrX	71300550	3'UTR	novel		0.27
UCEC	chrX	71283522	5'Flank	novel		0.24
UCEC	chrX	71283713	5'UTR	novel		0.4
UCEC	chrX	71300877	3'UTR	novel		0.32
UCEC	chrX	71301027	3'UTR	novel		0.34
UCEC	chrX	71297885	Nonsense_Mutation	novel	E360*	0.41
UCS	chrX	71294486	Missense_Mutation	novel	K203T	0.17
UCS	chrX	71300126	3'UTR	novel		0.35

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
THCA	DEL	0	0.21991

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0021	Kaplan-Meier Survival Analysis
KIRC	0.00035	Kaplan-Meier Survival Analysis
SARC	0.00049	Kaplan-Meier Survival Analysis
MESO	0.024	Kaplan-Meier Survival Analysis
LUSC	0.023	Kaplan-Meier Survival Analysis
BRCA	0.0057	Kaplan-Meier Survival Analysis
ESCA	0.0038	Kaplan-Meier Survival Analysis
TGCT	0.013	Kaplan-Meier Survival Analysis
KIRP	0.0001	Kaplan-Meier Survival Analysis
CESC	0.019	Kaplan-Meier Survival Analysis
KICH	0.0079	Kaplan-Meier Survival Analysis
UCEC	0.0018	Kaplan-Meier Survival Analysis
GBM	0.021	Kaplan-Meier Survival Analysis
LIHC	0.0019	Kaplan-Meier Survival Analysis
LGG	0.01	Kaplan-Meier Survival Analysis
UVM	0.025	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000147140 (Gene tree)
Gene ID: 4841
Gene Symbol: NONO
Alias: NRB54|NMT55|P54NRB|P54|PPP1R114
Full Name: non-POU domain containing octamer binding
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 17,977 bases
Position: chrX:71,283,192-71,301,168
Accession: 7871
RBP type: canonical RBP
Summary: This gene encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. A rearrangement between this gene and the transcription factor E3 gene has been observed in papillary renal cell carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes exist on Chromosomes 2 and 16. [provided by RefSeq, Feb 2009]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000406673	RRM_1	PF00076.22	3.5e-31	1	2
ENSP00000406673	RRM_1	PF00076.22	3.5e-31	2	2
ENSP00000276079	RRM_1	PF00076.22	6.1e-31	1	2
ENSP00000276079	RRM_1	PF00076.22	6.1e-31	2	2
ENSP00000362947	RRM_1	PF00076.22	6.1e-31	1	2
ENSP00000362947	RRM_1	PF00076.22	6.1e-31	2	2
ENSP00000362963	RRM_1	PF00076.22	6.1e-31	1	2
ENSP00000362963	RRM_1	PF00076.22	6.1e-31	2	2
ENSP00000441364	RRM_1	PF00076.22	8.3e-22	1	2
ENSP00000441364	RRM_1	PF00076.22	8.3e-22	2	2
ENSP00000413350	RRM_1	PF00076.22	6.3e-16	1	1
ENSP00000409773	RRM_1	PF00076.22	1.4e-10	1	1
ENSP00000410299	RRM_1	PF00076.22	2.7e-08	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
8626664	The transcription factor Spi-1/PU.1 binds RNA and interferes with the RNA-binding protein p54nrb.	J Biol Chem	1996 May 10	Hallier M	-
27550220	Congenital heart defects and left ventricular non-compaction in males with loss-of-function variants in NONO.	J Med Genet	2017 Jan	Scott DA	doi: 10.1136/jmedgenet-2016-104039
19650766	Oxidative modifications of glyceraldehyde-3-phosphate dehydrogenase play a key role in its multiple cellular functions.	Biochem J	2009 Sep 25	Hwang NR	doi: 10.1042/BJ20090854.
12403470	PSF and p54nrb bind a conserved stem in U5 snRNA.	RNA	2002 Oct	Peng R	-
9605521	Prolactin induces expression of FGF-2 and a novel FGF-responsive NonO/p54nrb-related mRNA in rat lymphoma cells.	Mol Cell Endocrinol	1998 Feb	Too CK	-
16263701	A novel subtractive antibody phage display method to discover disease markers.	Mol Cell Proteomics	2006 Feb	Hof D	-
27108701	Knockdown of p54nrb inhibits migration, invasion and TNF-α release of human acute monocytic leukemia THP1 cells.	Oncol Rep	2016 Jun	Zhang X	doi: 10.3892/or.2016.4756
26951683	EBV noncoding RNA EBER2 interacts with host RNA-binding proteins to regulate viral gene expression.	Proc Natl Acad Sci U S A	2016 Mar 22	Lee N	doi: 10.1073/pnas.1601773113
30725116	IGFBP-3 interacts with NONO and SFPQ in PARP-dependent DNA damage repair in triple-negative breast cancer.	Cell Mol Life Sci	2019 May	de Silva HC	doi: 10.1007/s00018-019-03033-4
15171797	Multisite phosphorylation of Pin1-associated mitotic phosphoproteins revealed by monoclonal antibodies MPM-2 and CC-3.	BMC Cell Biol	2004 Jun 1	Albert AL	-
21819346	The mitotic phosphorylation of p54(nrb) modulates its RNA binding activity.	Biochem Cell Biol	2011 Aug	Bruelle C	doi: 10.1139/O11-030.
21642354	p54nrb is a new regulator of progression of malignant melanoma.	Carcinogenesis	2011 Aug	Schiffner S	doi: 10.1093/carcin/bgr103
24402308	The open conformation of WASP regulates its nuclear localization and gene transcription in myeloid cells.	Int Immunol	2014 Jun	Looi CY	doi: 10.1093/intimm/dxt072
27064654	Structure, Dynamics, and Interaction of p54(nrb)/NonO RRM1 with 5' Splice Site RNA Sequence.	Biochemistry	2016 May 10	Duvignaud JB	doi: 10.1021/acs.biochem.5b01240
30824709	SFPQ and NONO suppress RNA:DNA-hybrid-related telomere instability.	Nat Commun	2019 Mar 1	Petti E	doi: 10.1038/s41467-019-08863-1.
9001221	The intracisternal A-particle proximal enhancer-binding protein activates transcription and is identical to the RNA- and DNA-binding protein p54nrb/NonO.	Mol Cell Biol	1997 Feb	Basu A	-
12810069	p54nrb acts as a transcriptional coactivator for activation function 1 of the human androgen receptor.	Biochem Biophys Res Commun	2003 Jul 4	Ishitani K	-
15590677	Identification of the polypyrimidine tract binding protein-associated splicing factor.p54(nrb) complex as a candidate DNA double-strand break rejoining factor.	J Biol Chem	2005 Feb 18	Bladen CL	-
22941645	PARP activation regulates the RNA-binding protein NONO in the DNA damage response to DNA double-strand breaks.	Nucleic Acids Res	2012 Nov 1	Krietsch J	doi: 10.1093/nar/gks798
1670777	Different forms of soluble cytoplasmic mRNA binding proteins and particles in Xenopus laevis oocytes and embryos.	J Cell Biol	1991 Jan	Murray MT	-
9360842	Loss of expression of a 55 kDa nuclear protein (nmt55) in estrogen receptor-negative human breast cancer.	Diagn Mol Pathol	1997 Aug	Traish AM	-
8371983	Purification and cDNA cloning of HeLa cell p54nrb, a nuclear protein with two RNA recognition motifs and extensive homology to human splicing factor PSF and Drosophila NONA/BJ6.	Nucleic Acids Res	1993 Aug 25	Dong B	-
11710964	Immunodetection of nmt55/p54nrb isoforms in human breast cancer.	BMC Cancer	2001	Pavao M	-
11525732	The fate of dsRNA in the nucleus: a p54(nrb)-containing complex mediates the nuclear retention of promiscuously A-to-I edited RNAs.	Cell	2001 Aug 24	Zhang Z	-
11168378	Identification of tyrosine-phosphorylated proteins associated with the nuclear envelope.	Eur J Biochem	2001 Jan	Otto H	-
10821857	Nuclear NonO/p54(nrb) protein is a nonclassical carbonic anhydrase.	J Biol Chem	2000 May 26	Karhumaa P	-
16148043	P54nrb forms a heterodimer with PSP1 that localizes to paraspeckles in an RNA-dependent manner.	Mol Biol Cell	2005 Nov	Fox AH	-
15984930	Functional analysis of the promoter of the mitochondrial phosphate carrier human gene: identification of activator and repressor elements and their transcription factors.	Biochem J	2005 Nov 1	Iacobazzi V	-
18677406	Paraspeckle protein p54nrb links Sox9-mediated transcription with RNA processing during chondrogenesis in mice.	J Clin Invest	2008 Sep	Hata K	doi: 10.1172/JCI31373.
17987630	Quantitative proteome analysis of cisplatin-induced apoptotic Jurkat T cells by stable isotope labeling with amino acids in cell culture, SDS-PAGE, and LC-MALDI-TOF/TOF MS.	Electrophoresis	2007 Dec	Schmidt F	-
21368873	Enhanced cartilage regeneration in MIA/CD-RAP deficient mice.	Cell Death Dis	2010 Nov 11	Schmid R	doi: 10.1038/cddis.2010.78.
20554522	Regulation of DNA Topoisomerase IIbeta through RNA-dependent association with heterogeneous nuclear ribonucleoprotein U (hnRNP U).	J Biol Chem	2010 Aug 20	Kawano S	doi: 10.1074/jbc.M110.112979
25436547	Paraspeckles: possible nuclear hubs by the RNA for the RNA.	Biomol Concepts	2012 Oct	Hirose T	doi: 10.1515/bmc-2012-0017.
28209515	Cell-type specific role of the RNA-binding protein, NONO, in the DNA double-strand break response in the mouse testes.	DNA Repair (Amst)	2017 Mar	Li S	doi: 10.1016/j.dnarep.2017.02.002
24413662	p54nrb/NonO and PSF promote U snRNA nuclear export by accelerating its export complex assembly.	Nucleic Acids Res	2014 Apr	Izumi H	doi: 10.1093/nar/gkt1365
26342078	Pro-oncogenic Roles of HLXB9 Protein in Insulinoma Cells through Interaction with Nono Protein and Down-regulation of the c-Met Inhibitor Cblb (Casitas B-lineage Lymphoma b).	J Biol Chem	2015 Oct 16	Desai SS	doi: 10.1074/jbc.M115.661413
28846091	NEAT1 scaffolds RNA-binding proteins and the Microprocessor to globally enhance pri-miRNA processing.	Nat Struct Mol Biol	2017 Oct	Jiang L	doi: 10.1038/nsmb.3455
29773901	Ets-1 promoter-associated noncoding RNA regulates the NONO/ERG/Ets-1 axis to drive gastric cancer progression.	Oncogene	2018 Aug	Li D	doi: 10.1038/s41388-018-0302-4
17967896	Identification of internal ribosome entry segment (IRES)-trans-acting factors for the Myc family of IRESs.	Mol Cell Biol	2008 Jan	Cobbold LC	-
19874820	hnRNP M interacts with PSF and p54(nrb) and co-localizes within defined nuclear structures.	Exp Cell Res	2010 Feb 1	Marko M	doi: 10.1016/j.yexcr.2009.10.021
12358429	Splicing and transcription-associated proteins PSF and p54nrb/nonO bind to the RNA polymerase II CTD.	RNA	2002 Sep	Emili A	-
16767080	Regulation of RNA-polymerase-II-dependent transcription by N-WASP and its nuclear-binding partners.	Nat Cell Biol	2006 Jul	Wu X	-
25326457	Quantitative proteomics reveals dynamic interaction of c-Jun N-terminal kinase (JNK) with RNA transport granule proteins splicing factor proline- and glutamine-rich (Sfpq) and non-POU domain-containing octamer-binding protein (Nono) during neuronal differentiation.	Mol Cell Proteomics	2015 Jan	Sury MD	doi: 10.1074/mcp.M114.039370
27259250	Long noncoding RNA GAPLINC promotes invasion in colorectal cancer by targeting SNAI2 through binding with PSF and NONO.	Oncotarget	2016 Jul 5	Yang P	doi: 10.18632/oncotarget.9741.
29535823	Overexpression of p54nrb/NONO induces differential EPHA6 splicing and contributes to castration-resistant prostate cancer growth.	Oncotarget	2018 Jan 8	Yamamoto R	doi: 10.18632/oncotarget.24063
30566058	A Novel Angiotensin II-Induced Long Noncoding RNA Giver Regulates Oxidative Stress, Inflammation, and Proliferation in Vascular Smooth Muscle Cells.	Circ Res	2018 Dec 7	Das S	doi: 10.1161/CIRCRESAHA.118.313207.
8355702	NonO, a non-POU-domain-containing, octamer-binding protein, is the mammalian homolog of Drosophila nonAdiss.	Mol Cell Biol	1993 Sep	Yang YS	-
15790595	The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis.	Hum Mol Genet	2005 May 1	Xu J	-
15312650	Kinesin transports RNA: isolation and characterization of an RNA-transporting granule.	Neuron	2004 Aug 19	Kanai Y	-
21566083	Consensus PP1 binding motifs regulate transcriptional corepression and alternative RNA splicing activities of the steroid receptor coregulators, p54nrb and PSF.	Mol Endocrinol	2011 Jul	Liu L	doi: 10.1210/me.2010-0517
27145786	Dependence of the structure and mechanics of metaphase chromosomes on oxidized cysteines.	Chromosome Res	2016 Sep	Eastland A	doi: 10.1007/s10577-016-9528-6
25838539	CARMing down the SINEs of anarchy: two paths to freedom from paraspeckle detention.	Genes Dev	2015 Apr 1	Elbarbary RA	doi: 10.1101/gad.261438.115.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000413858	NONO-204	855	-	ENSP00000413350	247 (aa)	-	C9JYS8
ENST00000486613	NONO-213	555	-	-	- (aa)	-	-
ENST00000276079	NONO-201	2713	-	ENSP00000276079	471 (aa)	-	Q15233
ENST00000474431	NONO-212	644	-	-	- (aa)	-	-
ENST00000471419	NONO-209	846	-	-	- (aa)	-	-
ENST00000420903	NONO-206	622	-	ENSP00000410299	124 (aa)	-	C9J4X2
ENST00000418921	NONO-205	703	-	ENSP00000409773	234 (aa)	-	H7C367
ENST00000454976	NONO-208	726	-	ENSP00000406673	207 (aa)	-	C9IZL7
ENST00000472185	NONO-210	397	-	-	- (aa)	-	-
ENST00000450092	NONO-207	491	-	ENSP00000415777	65 (aa)	-	C9JJ13
ENST00000373856	NONO-203	1921	-	ENSP00000362963	471 (aa)	-	Q15233
ENST00000535149	NONO-215	2882	-	ENSP00000441364	382 (aa)	-	Q15233
ENST00000373841	NONO-202	2606	-	ENSP00000362947	471 (aa)	-	Q15233
ENST00000490044	NONO-214	3215	-	-	- (aa)	-	-
ENST00000473525	NONO-211	1430	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000147140's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000147140's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000147140	NONO	97	56.944	ENSG00000116560	SFPQ	53	71.429
ENSG00000147140	NONO	73	30.189	ENSG00000151846	PABPC3	54	30.189
ENSG00000147140	NONO	53	30.328	ENSG00000066044	ELAVL1	80	31.148
ENSG00000147140	NONO	70	30.939	ENSG00000174740	PABPC5	87	30.939
ENSG00000147140	NONO	63	32.000	ENSG00000116001	TIA1	57	31.579
ENSG00000147140	NONO	53	36.620	ENSG00000173914	RBM4B	77	35.714
ENSG00000147140	NONO	50	31.897	ENSG00000011304	PTBP1	57	31.897
ENSG00000147140	NONO	60	32.857	ENSG00000173933	RBM4	77	35.714
ENSG00000147140	NONO	99	75.377	ENSG00000121390	PSPC1	91	59.072

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000147140	NONO	100	89.011	ENSAPOG00000023320	nono	95	64.612	Acanthochromis_polyacanthus
ENSG00000147140	NONO	100	100.000	ENSAMEG00000016057	NONO	100	99.788	Ailuropoda_melanoleuca
ENSG00000147140	NONO	83	89.011	ENSACIG00000019987	nono	94	66.667	Amphilophus_citrinellus
ENSG00000147140	NONO	100	89.011	ENSAOCG00000018863	nono	95	64.073	Amphiprion_ocellaris
ENSG00000147140	NONO	97	73.932	ENSAPEG00000011383	nono	87	73.803	Amphiprion_percula
ENSG00000147140	NONO	99	94.634	ENSAPLG00000002642	NONO	98	88.863	Anas_platyrhynchos
ENSG00000147140	NONO	100	90.338	ENSACAG00000015026	NONO	99	84.567	Anolis_carolinensis
ENSG00000147140	NONO	100	100.000	ENSANAG00000033266	-	100	100.000	Aotus_nancymaae
ENSG00000147140	NONO	100	73.430	ENSANAG00000035751	-	96	88.462	Aotus_nancymaae
ENSG00000147140	NONO	99	78.556	ENSANAG00000027089	-	99	78.556	Aotus_nancymaae
ENSG00000147140	NONO	98	93.750	ENSANAG00000026006	-	90	79.856	Aotus_nancymaae
ENSG00000147140	NONO	83	90.110	ENSACLG00000012045	nono	91	77.259	Astatotilapia_calliptera
ENSG00000147140	NONO	85	82.500	ENSAMXG00000033933	nono	91	64.516	Astyanax_mexicanus
ENSG00000147140	NONO	100	100.000	ENSBTAG00000012152	NONO	100	99.575	Bos_taurus
ENSG00000147140	NONO	100	96.923	ENSBTAG00000051220	-	97	90.541	Bos_taurus
ENSG00000147140	NONO	50	92.308	ENSBTAG00000054689	-	82	98.000	Bos_taurus
ENSG00000147140	NONO	100	100.000	ENSCJAG00000048149	-	91	97.842	Callithrix_jacchus
ENSG00000147140	NONO	100	100.000	ENSCJAG00000036744	NONO	100	100.000	Callithrix_jacchus
ENSG00000147140	NONO	98	98.438	ENSCAFG00000013766	-	100	90.625	Canis_familiaris
ENSG00000147140	NONO	100	98.953	ENSCAFG00000003207	-	100	98.514	Canis_familiaris
ENSG00000147140	NONO	100	92.308	ENSCAFG00000030809	-	99	86.385	Canis_familiaris
ENSG00000147140	NONO	100	100.000	ENSCAFG00000017071	NONO	100	99.788	Canis_familiaris
ENSG00000147140	NONO	100	99.517	ENSCAFG00020020298	-	100	97.028	Canis_lupus_dingo
ENSG00000147140	NONO	100	96.923	ENSCAFG00020000494	-	98	92.617	Canis_lupus_dingo
ENSG00000147140	NONO	100	92.308	ENSCAFG00020025025	-	68	93.056	Canis_lupus_dingo
ENSG00000147140	NONO	100	96.923	ENSCAFG00020016501	-	91	89.928	Canis_lupus_dingo
ENSG00000147140	NONO	100	96.923	ENSCAFG00020027125	-	91	91.367	Canis_lupus_dingo
ENSG00000147140	NONO	97	90.270	ENSCHIG00000009602	-	90	90.027	Capra_hircus
ENSG00000147140	NONO	76	85.393	ENSCHIG00000025698	-	90	88.000	Capra_hircus
ENSG00000147140	NONO	100	100.000	ENSCHIG00000000365	-	100	99.575	Capra_hircus
ENSG00000147140	NONO	99	94.231	ENSTSYG00000036306	-	100	89.787	Carlito_syrichta
ENSG00000147140	NONO	100	92.308	ENSTSYG00000034207	-	99	86.412	Carlito_syrichta
ENSG00000147140	NONO	100	99.034	ENSTSYG00000007423	-	99	96.815	Carlito_syrichta
ENSG00000147140	NONO	100	98.429	ENSCAPG00000011616	-	100	95.436	Cavia_aperea
ENSG00000147140	NONO	99	83.058	ENSCAPG00000002723	-	100	70.488	Cavia_aperea
ENSG00000147140	NONO	100	82.609	ENSCAPG00000002354	-	97	72.222	Cavia_aperea
ENSG00000147140	NONO	100	100.000	ENSCAPG00000006522	-	84	79.775	Cavia_aperea
ENSG00000147140	NONO	100	99.738	ENSCPOG00000010263	-	100	96.473	Cavia_porcellus
ENSG00000147140	NONO	100	92.408	ENSCPOG00000038668	-	100	89.809	Cavia_porcellus
ENSG00000147140	NONO	100	94.231	ENSCPOG00000036719	-	93	92.328	Cavia_porcellus
ENSG00000147140	NONO	100	96.859	ENSCPOG00000023605	-	100	93.608	Cavia_porcellus
ENSG00000147140	NONO	100	82.609	ENSCPOG00000026604	-	99	71.882	Cavia_porcellus
ENSG00000147140	NONO	100	83.077	ENSCCAG00000026138	-	87	83.704	Cebus_capucinus
ENSG00000147140	NONO	100	100.000	ENSCATG00000039509	NONO	100	90.870	Cercocebus_atys
ENSG00000147140	NONO	100	99.738	ENSCLAG00000003642	NONO	100	98.734	Chinchilla_lanigera
ENSG00000147140	NONO	100	100.000	ENSCSAG00000011368	-	73	100.000	Chlorocebus_sabaeus
ENSG00000147140	NONO	78	96.078	ENSCHOG00000002343	-	74	100.000	Choloepus_hoffmanni
ENSG00000147140	NONO	99	96.098	ENSCPBG00000016659	NONO	100	84.855	Chrysemys_picta_bellii
ENSG00000147140	NONO	100	100.000	ENSCANG00000025310	NONO	100	100.000	Colobus_angolensis_palliatus
ENSG00000147140	NONO	100	99.215	ENSCGRG00001000065	Nono	100	98.517	Cricetulus_griseus_chok1gshd
ENSG00000147140	NONO	100	99.215	ENSCGRG00000004508	Nono	100	99.284	Cricetulus_griseus_crigri
ENSG00000147140	NONO	99	62.847	ENSCSEG00000010708	nono	90	65.446	Cynoglossus_semilaevis
ENSG00000147140	NONO	99	63.194	ENSCSEG00000008189	NONO	94	65.217	Cynoglossus_semilaevis
ENSG00000147140	NONO	94	91.209	ENSCVAG00000003978	nono	82	73.278	Cyprinodon_variegatus
ENSG00000147140	NONO	95	89.011	ENSDARG00000020482	nono	100	66.540	Danio_rerio
ENSG00000147140	NONO	81	78.632	ENSDNOG00000032215	-	99	71.186	Dasypus_novemcinctus
ENSG00000147140	NONO	100	73.684	ENSDNOG00000031430	-	100	82.609	Dasypus_novemcinctus
ENSG00000147140	NONO	100	98.551	ENSDNOG00000003267	-	88	98.605	Dasypus_novemcinctus
ENSG00000147140	NONO	100	99.738	ENSDORG00000009294	Nono	100	98.301	Dipodomys_ordii
ENSG00000147140	NONO	93	99.718	ENSETEG00000013823	NONO	86	99.718	Echinops_telfairi
ENSG00000147140	NONO	52	82.645	ENSEASG00005002149	-	83	74.233	Equus_asinus_asinus
ENSG00000147140	NONO	100	100.000	ENSECAG00000008502	NONO	100	99.788	Equus_caballus
ENSG00000147140	NONO	100	99.215	ENSEEUG00000014404	NONO	100	98.514	Erinaceus_europaeus
ENSG00000147140	NONO	95	89.011	ENSELUG00000001083	nono	100	63.169	Esox_lucius
ENSG00000147140	NONO	100	100.000	ENSFCAG00000043511	-	100	99.788	Felis_catus
ENSG00000147140	NONO	100	93.846	ENSFCAG00000026862	-	91	94.964	Felis_catus
ENSG00000147140	NONO	100	90.769	ENSFCAG00000038415	-	91	87.770	Felis_catus
ENSG00000147140	NONO	100	88.889	ENSFALG00000011765	NONO	100	74.841	Ficedula_albicollis
ENSG00000147140	NONO	100	95.385	ENSFDAG00000006143	-	100	80.294	Fukomys_damarensis
ENSG00000147140	NONO	100	99.517	ENSFDAG00000012809	-	100	99.363	Fukomys_damarensis
ENSG00000147140	NONO	96	89.011	ENSFHEG00000009714	nono	85	72.176	Fundulus_heteroclitus
ENSG00000147140	NONO	99	94.634	ENSGALG00000005507	NONO	100	84.025	Gallus_gallus
ENSG00000147140	NONO	96	91.209	ENSGAFG00000011460	nono	83	74.105	Gambusia_affinis
ENSG00000147140	NONO	85	87.912	ENSGACG00000011824	nono	94	65.297	Gasterosteus_aculeatus
ENSG00000147140	NONO	100	64.000	ENSGAGG00000003740	-	93	68.712	Gopherus_agassizii
ENSG00000147140	NONO	99	96.098	ENSGAGG00000025400	-	91	86.681	Gopherus_agassizii
ENSG00000147140	NONO	100	100.000	ENSGGOG00000037538	-	91	99.281	Gorilla_gorilla
ENSG00000147140	NONO	100	100.000	ENSGGOG00000006194	NONO	97	99.766	Gorilla_gorilla
ENSG00000147140	NONO	100	90.576	ENSGGOG00000036327	-	99	86.837	Gorilla_gorilla
ENSG00000147140	NONO	83	90.110	ENSHBUG00000010741	nono	94	66.667	Haplochromis_burtoni
ENSG00000147140	NONO	100	99.738	ENSHGLG00000005550	NONO	100	98.938	Heterocephalus_glaber_female
ENSG00000147140	NONO	100	99.738	ENSHGLG00100013511	NONO	100	98.938	Heterocephalus_glaber_male
ENSG00000147140	NONO	99	64.931	ENSHCOG00000016441	nono	84	76.554	Hippocampus_comes
ENSG00000147140	NONO	86	80.100	ENSIPUG00000018271	nono	91	63.488	Ictalurus_punctatus
ENSG00000147140	NONO	100	100.000	ENSSTOG00000015869	NONO	100	99.788	Ictidomys_tridecemlineatus
ENSG00000147140	NONO	100	81.538	ENSJJAG00000001971	-	100	77.707	Jaculus_jaculus
ENSG00000147140	NONO	100	98.953	ENSJJAG00000017151	-	100	98.726	Jaculus_jaculus
ENSG00000147140	NONO	97	73.504	ENSKMAG00000002798	nono	89	67.488	Kryptolebias_marmoratus
ENSG00000147140	NONO	88	83.010	ENSLBEG00000022623	nono	84	74.792	Labrus_bergylta
ENSG00000147140	NONO	100	73.206	ENSLACG00000000598	NONO	94	78.987	Latimeria_chalumnae
ENSG00000147140	NONO	100	89.362	ENSLOCG00000014739	nono	100	66.667	Lepisosteus_oculatus
ENSG00000147140	NONO	100	100.000	ENSLAFG00000013422	NONO	100	98.941	Loxodonta_africana
ENSG00000147140	NONO	100	100.000	ENSMFAG00000041557	NONO	100	100.000	Macaca_fascicularis
ENSG00000147140	NONO	100	100.000	ENSMMUG00000020481	NONO	100	100.000	Macaca_mulatta
ENSG00000147140	NONO	100	100.000	ENSMNEG00000009698	NONO	100	100.000	Macaca_nemestrina
ENSG00000147140	NONO	100	100.000	ENSMLEG00000042452	NONO	100	100.000	Mandrillus_leucophaeus
ENSG00000147140	NONO	94	90.110	ENSMAMG00000007314	nono	94	65.446	Mastacembelus_armatus
ENSG00000147140	NONO	83	90.110	ENSMZEG00005010199	nono	91	77.259	Maylandia_zebra
ENSG00000147140	NONO	99	94.634	ENSMGAG00000008869	NONO	98	89.100	Meleagris_gallopavo
ENSG00000147140	NONO	100	99.476	ENSMAUG00000016243	Nono	100	98.101	Mesocricetus_auratus
ENSG00000147140	NONO	100	100.000	ENSMICG00000000232	NONO	100	98.726	Microcebus_murinus
ENSG00000147140	NONO	100	82.609	ENSMOCG00000020099	-	95	79.193	Microtus_ochrogaster
ENSG00000147140	NONO	100	70.769	ENSMOCG00000000761	-	89	81.295	Microtus_ochrogaster
ENSG00000147140	NONO	100	88.889	ENSMOCG00000021293	-	100	85.563	Microtus_ochrogaster
ENSG00000147140	NONO	100	96.923	ENSMOCG00000006594	-	91	92.806	Microtus_ochrogaster
ENSG00000147140	NONO	100	85.915	ENSMOCG00000015871	-	91	92.414	Microtus_ochrogaster
ENSG00000147140	NONO	100	99.215	ENSMOCG00000005532	-	99	97.996	Microtus_ochrogaster
ENSG00000147140	NONO	100	89.011	ENSMMOG00000015503	nono	85	66.359	Mola_mola
ENSG00000147140	NONO	99	97.073	ENSMODG00000004445	NONO	99	92.111	Monodelphis_domestica
ENSG00000147140	NONO	97	73.504	ENSMALG00000001310	nono	87	73.003	Monopterus_albus
ENSG00000147140	NONO	100	87.143	MGP_CAROLIEiJ_G0033288	-	100	91.089	Mus_caroli
ENSG00000147140	NONO	100	99.476	ENSMUSG00000031311	Nono	100	98.309	Mus_musculus
ENSG00000147140	NONO	100	99.476	MGP_PahariEiJ_G0031826	Nono	100	97.895	Mus_pahari
ENSG00000147140	NONO	100	100.000	ENSMPUG00000004937	NONO	100	99.788	Mustela_putorius_furo
ENSG00000147140	NONO	100	99.738	ENSMLUG00000002489	NONO	89	99.151	Myotis_lucifugus
ENSG00000147140	NONO	100	100.000	ENSNGAG00000010857	Nono	100	98.726	Nannospalax_galili
ENSG00000147140	NONO	83	90.110	ENSNBRG00000017083	nono	94	66.897	Neolamprologus_brichardi
ENSG00000147140	NONO	100	92.308	ENSNLEG00000030907	-	96	87.162	Nomascus_leucogenys
ENSG00000147140	NONO	100	100.000	ENSNLEG00000001278	NONO	100	100.000	Nomascus_leucogenys
ENSG00000147140	NONO	100	100.000	ENSMEUG00000004294	NONO	100	84.076	Notamacropus_eugenii
ENSG00000147140	NONO	69	100.000	ENSOPRG00000001139	-	69	100.000	Ochotona_princeps
ENSG00000147140	NONO	100	94.764	ENSODEG00000002224	-	100	92.781	Octodon_degus
ENSG00000147140	NONO	100	70.064	ENSODEG00000011878	-	100	66.879	Octodon_degus
ENSG00000147140	NONO	92	73.789	ENSODEG00000000530	-	89	67.517	Octodon_degus
ENSG00000147140	NONO	99	70.673	ENSODEG00000004982	-	99	65.795	Octodon_degus
ENSG00000147140	NONO	100	98.089	ENSODEG00000002994	-	100	91.295	Octodon_degus
ENSG00000147140	NONO	99	64.583	ENSONIG00000020497	nono	94	66.667	Oreochromis_niloticus
ENSG00000147140	NONO	99	66.341	ENSOCUG00000024801	-	97	60.515	Oryctolagus_cuniculus
ENSG00000147140	NONO	100	100.000	ENSOCUG00000021848	-	90	99.063	Oryctolagus_cuniculus
ENSG00000147140	NONO	95	90.110	ENSORLG00000012801	nono	83	71.625	Oryzias_latipes
ENSG00000147140	NONO	96	74.678	ENSORLG00020003761	nono	78	74.277	Oryzias_latipes_hni
ENSG00000147140	NONO	95	90.110	ENSORLG00015018033	nono	83	71.625	Oryzias_latipes_hsok
ENSG00000147140	NONO	92	90.110	ENSOMEG00000012702	nono	82	73.333	Oryzias_melastigma
ENSG00000147140	NONO	100	99.739	ENSOGAG00000004834	NONO	100	99.364	Otolemur_garnettii
ENSG00000147140	NONO	100	99.738	ENSOARG00000016966	NONO	99	99.363	Ovis_aries
ENSG00000147140	NONO	100	92.147	ENSPPAG00000041394	-	99	88.323	Pan_paniscus
ENSG00000147140	NONO	100	100.000	ENSPPAG00000032487	NONO	100	100.000	Pan_paniscus
ENSG00000147140	NONO	100	100.000	ENSPPRG00000024537	-	100	99.788	Panthera_pardus
ENSG00000147140	NONO	51	92.500	ENSPPRG00000011431	-	99	96.154	Panthera_pardus
ENSG00000147140	NONO	100	90.769	ENSPPRG00000003451	-	92	80.282	Panthera_pardus
ENSG00000147140	NONO	100	99.738	ENSPTIG00000016068	-	100	99.575	Panthera_tigris_altaica
ENSG00000147140	NONO	100	91.885	ENSPTRG00000051228	-	100	88.110	Pan_troglodytes
ENSG00000147140	NONO	100	100.000	ENSPTRG00000022010	NONO	100	100.000	Pan_troglodytes
ENSG00000147140	NONO	100	100.000	ENSPANG00000013979	NONO	100	100.000	Papio_anubis
ENSG00000147140	NONO	100	100.000	ENSPANG00000035017	-	99	72.822	Papio_anubis
ENSG00000147140	NONO	97	65.229	ENSPKIG00000019475	-	92	77.654	Paramormyrops_kingsleyae
ENSG00000147140	NONO	100	86.813	ENSPKIG00000014500	nono	100	65.618	Paramormyrops_kingsleyae
ENSG00000147140	NONO	99	96.098	ENSPSIG00000010678	NONO	99	86.469	Pelodiscus_sinensis
ENSG00000147140	NONO	94	87.912	ENSPMGG00000023030	nono	82	72.727	Periophthalmus_magnuspinnatus
ENSG00000147140	NONO	100	99.476	ENSPEMG00000011150	Nono	100	98.517	Peromyscus_maniculatus_bairdii
ENSG00000147140	NONO	99	97.073	ENSPCIG00000026515	NONO	100	87.841	Phascolarctos_cinereus
ENSG00000147140	NONO	96	89.011	ENSPFOG00000016436	nono	82	67.769	Poecilia_formosa
ENSG00000147140	NONO	96	89.011	ENSPLAG00000017492	nono	82	72.727	Poecilia_latipinna
ENSG00000147140	NONO	83	89.011	ENSPMEG00000021530	nono	83	73.003	Poecilia_mexicana
ENSG00000147140	NONO	100	89.011	ENSPREG00000010014	nono	82	73.554	Poecilia_reticulata
ENSG00000147140	NONO	100	100.000	ENSPPYG00000020451	NONO	100	99.575	Pongo_abelii
ENSG00000147140	NONO	100	99.738	ENSPCAG00000002541	NONO	100	98.105	Procavia_capensis
ENSG00000147140	NONO	100	100.000	ENSPCOG00000008197	NONO	100	99.788	Propithecus_coquereli
ENSG00000147140	NONO	100	99.215	ENSPVAG00000016503	NONO	100	98.726	Pteropus_vampyrus
ENSG00000147140	NONO	57	72.794	ENSPNYG00000018329	nono	98	74.850	Pundamilia_nyererei
ENSG00000147140	NONO	95	73.043	ENSPNAG00000008232	nono	82	63.387	Pygocentrus_nattereri
ENSG00000147140	NONO	100	99.215	ENSRNOG00000003689	Nono	100	97.689	Rattus_norvegicus
ENSG00000147140	NONO	96	100.000	ENSRBIG00000037966	NONO	100	100.000	Rhinopithecus_bieti
ENSG00000147140	NONO	100	100.000	ENSRROG00000043203	NONO	100	99.788	Rhinopithecus_roxellana
ENSG00000147140	NONO	52	90.323	ENSRROG00000004598	-	91	100.000	Rhinopithecus_roxellana
ENSG00000147140	NONO	55	74.419	ENSSBOG00000023807	-	94	80.488	Saimiri_boliviensis_boliviensis
ENSG00000147140	NONO	99	82.803	ENSSBOG00000018932	-	99	75.687	Saimiri_boliviensis_boliviensis
ENSG00000147140	NONO	56	79.231	ENSSBOG00000021974	-	96	88.344	Saimiri_boliviensis_boliviensis
ENSG00000147140	NONO	100	100.000	ENSSBOG00000032772	-	100	99.788	Saimiri_boliviensis_boliviensis
ENSG00000147140	NONO	53	86.400	ENSSBOG00000033417	-	92	90.000	Saimiri_boliviensis_boliviensis
ENSG00000147140	NONO	100	100.000	ENSSBOG00000027683	-	99	96.178	Saimiri_boliviensis_boliviensis
ENSG00000147140	NONO	99	97.073	ENSSHAG00000010195	NONO	100	90.126	Sarcophilus_harrisii
ENSG00000147140	NONO	86	86.813	ENSSFOG00015000137	-	76	77.083	Scleropages_formosus
ENSG00000147140	NONO	97	75.319	ENSSFOG00015008964	nono	90	80.308	Scleropages_formosus
ENSG00000147140	NONO	50	74.359	ENSSMAG00000004730	nono	68	73.684	Scophthalmus_maximus
ENSG00000147140	NONO	61	54.082	ENSSMAG00000004703	-	55	65.657	Scophthalmus_maximus
ENSG00000147140	NONO	85	89.011	ENSSDUG00000021886	nono	94	65.297	Seriola_dumerili
ENSG00000147140	NONO	85	89.011	ENSSLDG00000012392	nono	94	65.297	Seriola_lalandi_dorsalis
ENSG00000147140	NONO	100	97.585	ENSSARG00000007959	NONO	100	83.101	Sorex_araneus
ENSG00000147140	NONO	97	96.585	ENSSPUG00000003116	NONO	100	87.500	Sphenodon_punctatus
ENSG00000147140	NONO	100	89.011	ENSSPAG00000012663	nono	95	65.525	Stegastes_partitus
ENSG00000147140	NONO	100	100.000	ENSSSCG00000023245	NONO	100	99.788	Sus_scrofa
ENSG00000147140	NONO	99	95.122	ENSTGUG00000007048	NONO	100	84.810	Taeniopygia_guttata
ENSG00000147140	NONO	96	75.536	ENSTRUG00000005554	nono	94	66.136	Takifugu_rubripes
ENSG00000147140	NONO	100	100.000	ENSTTRG00000009605	NONO	100	99.788	Tursiops_truncatus
ENSG00000147140	NONO	100	99.517	ENSUAMG00000008220	NONO	100	97.028	Ursus_americanus
ENSG00000147140	NONO	100	100.000	ENSUMAG00000021550	NONO	100	99.788	Ursus_maritimus
ENSG00000147140	NONO	100	100.000	ENSVPAG00000002272	NONO	100	99.788	Vicugna_pacos
ENSG00000147140	NONO	100	96.923	ENSVVUG00000022693	-	79	90.972	Vulpes_vulpes
ENSG00000147140	NONO	100	80.000	ENSVVUG00000028732	-	90	84.173	Vulpes_vulpes
ENSG00000147140	NONO	95	90.323	ENSVVUG00000012308	-	90	91.176	Vulpes_vulpes
ENSG00000147140	NONO	100	86.154	ENSVVUG00000003851	-	91	86.331	Vulpes_vulpes
ENSG00000147140	NONO	100	95.714	ENSVVUG00000003390	-	100	94.726	Vulpes_vulpes
ENSG00000147140	NONO	100	88.000	ENSXETG00000020868	nono	99	75.636	Xenopus_tropicalis
ENSG00000147140	NONO	96	90.110	ENSXCOG00000015587	nono	83	74.105	Xiphophorus_couchianus
ENSG00000147140	NONO	96	90.110	ENSXMAG00000019883	nono	83	74.105	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000976	transcription regulatory region sequence-specific DNA binding	21873635.	IBA	Function
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	-	ISS	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0002218	activation of innate immune response	28712728.	IDA	Process
GO:0003682	chromatin binding	-	ISS	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	15790595.16148043.16169070.16189514.16417406.16767080.18077367.18457437.19874820.21988832.22416126.25416956.25765647.30021884.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	15790595.	IDA	Component
GO:0005634	nucleus	-	ISS	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005730	nucleolus	-	IEA	Component
GO:0006281	DNA repair	-	IEA	Process
GO:0006310	DNA recombination	-	IEA	Process
GO:0006357	regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0006397	mRNA processing	-	IEA	Process
GO:0007623	circadian rhythm	-	ISS	Process
GO:0008380	RNA splicing	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016363	nuclear matrix	19874820.	IDA	Component
GO:0016607	nuclear speck	-	IEA	Component
GO:0042382	paraspeckles	19217333.	IDA	Component
GO:0042752	regulation of circadian rhythm	-	ISS	Process
GO:0042802	identical protein binding	16148043.16189514.21988832.22416126.23555304.	IPI	Function
GO:0045087	innate immune response	-	IEA	Process
GO:0045892	negative regulation of transcription, DNA-templated	-	ISS	Process
GO:0070888	E-box binding	-	ISS	Function
GO:0090575	RNA polymerase II transcription factor complex	-	ISS	Component
GO:1903377	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	15790595.	IDA	Process

EuRBPDB

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Cell lines and drugs in GSE70138 or GSE92742

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

PPI

Paralogs

Orthologs

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.