EuRBPDB

Note: to get the extension of tumor abbreviations.

Cancer Related Information
Basic Information

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
16799630	ZNF185, an actin-cytoskeleton-associated growth inhibitory LIM protein in prostate cancer.	Oncogene	2007 Jan 4	Zhang JS	-
12873976	Transcriptional silencing of zinc finger protein 185 identified by expression profiling is associated with prostate cancer progression.	Cancer Res	2003 Jul 15	Vanaja DK	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chrX	152959870	Silent	novel	F526F	0.26
BLCA	chrX	152959878	Missense_Mutation	NA	R529L	0.44
BLCA	chrX	152969443	Silent	NA	L644L	0.75
BLCA	chrX	152970470	Missense_Mutation	novel	D667Y	0.68
BRCA	chrX	152914777	Silent	rs782247502	T34T	0.41
BRCA	chrX	152920732	Missense_Mutation	novel	P213T	0.1
BRCA	chrX	152971298	3'UTR	novel		0.67
BRCA	chrX	152959761	Missense_Mutation	NA	R490K	0.12
BRCA	chrX	152967236	Missense_Mutation	novel	E622D	0.33
BRCA	chrX	152914740	Missense_Mutation	novel	R22H	0.44
BRCA	chrX	152963883	Missense_Mutation	NA	A550V	0.27
CESC	chrX	152959696	Splice_Region	novel		0.12
CESC	chrX	152932909	Silent	novel	S352S	0.06
CESC	chrX	152938112	Missense_Mutation	NA	R386M	0.3
CESC	chrX	152917913	Intron	rs373313088		0.27
CESC	chrX	152914780	Silent	novel	L35L	0.33
CESC	chrX	152914788	Missense_Mutation	novel	D38G	0.45
CESC	chrX	152917972	Intron	novel		0.16
CESC	chrX	152945354	Missense_Mutation	novel	Q432H	0.18
CESC	chrX	152945344	Missense_Mutation	novel	R429I	0.22
CESC	chrX	152967172	Missense_Mutation	novel	S601N	0.06
CESC	chrX	152920717	Nonsense_Mutation	NA	Q208*	0.33
CHOL	chrX	152917311	Frame_Shift_Ins	novel	*S98Tfs23**	0.55
COAD	chrX	152932897	Silent	rs782288327	G348G	0.61
COAD	chrX	152920729	Missense_Mutation	novel	A212T	0.13
COAD	chrX	152931758	Missense_Mutation	NA	P334L	0.39
COAD	chrX	152932917	Missense_Mutation	NA	T355M	0.13
COAD	chrX	152932910	Missense_Mutation	rs201390993	G353R	0.07
COAD	chrX	152945340	Missense_Mutation	novel	P428S	0.27
COAD	chrX	152945383	Missense_Mutation	novel	P442H	0.06
COAD	chrX	152928653	Silent	novel	E302E	0.15
COAD	chrX	152922213	Nonsense_Mutation	novel	Q232*	0.24
ESCA	chrX	152928636	Missense_Mutation	novel	V297L	0.51
ESCA	chrX	152928638	Silent	novel	V297V	0.73
ESCA	chrX	152932949	Missense_Mutation	novel	D366Y	0.49
ESCA	chrX	152922749	Missense_Mutation	NA	R256Q	0.34
ESCA	chrX	152936462	Intron	novel		0.88
GBM	chrX	152914481	5'UTR	novel		0.17
GBM	chrX	152965462	Silent	novel	F577F	0.18
HNSC	chrX	152945310	Missense_Mutation	rs781800037	G418R	0.33
HNSC	chrX	152945441	Silent	novel	V461V	0.6
HNSC	chrX	152920345	Missense_Mutation	novel	G183D	0.22
HNSC	chrX	152917135	Missense_Mutation	novel	P77S	0.13
KICH	chrX	152922810	Splice_Site	novel	X276_splice	0.39
KIRC	chrX	152959727	Missense_Mutation	NA	V479L	0.1
KIRC	chrX	152963873	Missense_Mutation	NA	T547S	0.32
KIRC	chrX	152917284	Splice_Site	NA	X88_splice	0.31
KIRC	chrX	152918134	Silent	NA	T137T	0.17
LGG	chrX	152914504	Silent	NA	A5A	0.59
LGG	chrX	152919055	Silent	novel	P168P	0.12
LGG	chrX	152919056	Missense_Mutation	novel	F169L	0.12
LIHC	chrX	152941770	Intron	novel		0.44
LIHC	chrX	152945445	Nonsense_Mutation	novel	R463*	0.06
LIHC	chrX	152922219	Missense_Mutation	novel	P234S	0.43
LIHC	chrX	152945449	Missense_Mutation	novel	E464G	0.16
LIHC	chrX	152932918	Silent	NA	T355T	0.43
LIHC	chrX	152938145	Missense_Mutation	NA	A397V	0.79
LIHC	chrX	152959778	Missense_Mutation	novel	G496C	0.29
LIHC	chrX	152917312	Silent	NA	S97S	0.26
LUAD	chrX	152914497	Missense_Mutation	novel	I3S	0.38
LUAD	chrX	152914762	Missense_Mutation	NA	M29I	0.63
LUAD	chrX	152915156	Silent	NA	R59R	0.37
LUAD	chrX	152918982	Splice_Site	novel	X144_splice	0.45
LUAD	chrX	152918095	Silent	NA	A124A	0.5
LUAD	chrX	152920396	Missense_Mutation	novel	A200D	0.17
LUAD	chrX	152932917	Missense_Mutation	NA	T355M	0.35
LUSC	chrX	152922744	Silent	rs140454766	A254A	0.64
LUSC	chrX	152919072	Missense_Mutation	NA	Q174R	0.97
LUSC	chrX	152945329	Missense_Mutation	novel	R424M	0.75
LUSC	chrX	152919079	Splice_Region	NA	R176R	0.12
LUSC	chrX	152970498	Missense_Mutation	novel	R676P	0.17
LUSC	chrX	152959805	Missense_Mutation	NA	T505S	0.14
LUSC	chrX	152945278	Missense_Mutation	novel	D407V	0.94
OV	chrX	152963894	Missense_Mutation	novel	Q554K	0.12
OV	chrX	152970441	Splice_Site	rs782445245	X658_splice	0.62
OV	chrX	152945428	Missense_Mutation	NA	S457Y	0.55
PCPG	chrX	152917168	Splice_Region	novel	R88R	0.09
READ	chrX	152920707	Splice_Region	novel		0.2
SKCM	chrX	152922794	Missense_Mutation	novel	G271E	0.37
SKCM	chrX	152959848	Missense_Mutation	rs782746511	S519N	0.32
SKCM	chrX	152931776	Missense_Mutation	NA	R340K	0.91
SKCM	chrX	152917145	Missense_Mutation	NA	R80K	0.28
SKCM	chrX	152959882	Silent	novel	E530E	0.33
SKCM	chrX	152959788	Missense_Mutation	NA	G499E	0.18
SKCM	chrX	152932919	Missense_Mutation	novel	G356S	1
SKCM	chrX	152931720	Silent	novel	L321L	0.29
SKCM	chrX	152931721	Nonsense_Mutation	novel	Q322*	0.29
SKCM	chrX	152959778	Missense_Mutation	NA	G496S	0.6
SKCM	chrX	152959741	Silent	rs376631959	V483V	0.89
SKCM	chrX	152917323	Missense_Mutation	novel	P101L	0.99
SKCM	chrX	152920704	Splice_Region	novel		0.44
STAD	chrX	152969414	Missense_Mutation	rs782634433	R634H	0.58
STAD	chrX	152959870	Silent	novel	F526F	0.58
STAD	chrX	152959706	Missense_Mutation	NA	T472S	0.1
STAD	chrX	152931735	Silent	NA	A326A	0.5
STAD	chrX	152967205	Missense_Mutation	NA	K612T	0.47
STAD	chrX	152959826	Missense_Mutation	novel	S512G	0.56
STAD	chrX	152917131	Splice_Region	rs782048278	R75R	0.22
STAD	chrX	152945373	Missense_Mutation	rs782678540	A439T	0.55
TGCT	chrX	152941804	Intron	novel		0.09
THCA	chrX	152970525	Missense_Mutation	NA	Y685F	0.1
THYM	chrX	152919025	In_Frame_Ins	rs781814997	E165dup	0.53
UCEC	chrX	152945309	Silent	rs782792023	V417V	0.39
UCEC	chrX	152931715	Nonsense_Mutation	novel	E320*	0.29
UCEC	chrX	152938074	Splice_Region	novel	S373S	0.11
UCEC	chrX	152914748	Missense_Mutation	rs782480857	V25I	0.44
UCEC	chrX	152917350	Missense_Mutation	NA	G110E	0.31
UCEC	chrX	152945411	Silent	NA	Q451Q	0.28
UCEC	chrX	152970440	Splice_Region	novel		0.3
UCEC	chrX	152920339	Missense_Mutation	novel	A181V	0.45
UCEC	chrX	152918122	Silent	novel	G133G	0.12
UCEC	chrX	152945302	Missense_Mutation	rs782162377	T415I	0.4
UCEC	chrX	152959855	Silent	novel	S521S	0.36
UCEC	chrX	152965494	Missense_Mutation	novel	S588F	0.06
UCEC	chrX	152917966	Intron	novel		0.44
UCEC	chrX	152919037	Missense_Mutation	novel	E162D	0.08
UCEC	chrX	152920714	Missense_Mutation	NA	T207A	0.32
UCEC	chrX	152965462	Silent	novel	F577F	0.32
UCEC	chrX	152917139	Missense_Mutation	novel	S78N	0.3
UCEC	chrX	152959712	Missense_Mutation	novel	F474V	0.32
UCEC	chrX	152969381	Splice_Site	novel	X623_splice	0.44
UCEC	chrX	152931679	Missense_Mutation	novel	P308T	0.33
UCEC	chrX	152920729	Missense_Mutation	novel	A212T	0.15
UCEC	chrX	152914769	Nonsense_Mutation	rs374950247	R32*	0.36
UCEC	chrX	152915163	Missense_Mutation	rs368172395	A62T	0.6
UCEC	chrX	152931689	Missense_Mutation	novel	K311R	0.15
UCEC	chrX	152915171	Silent	novel	S64S	0.24
UCEC	chrX	152920733	Missense_Mutation	rs782183263	P213L	0.43
UCEC	chrX	152932955	Missense_Mutation	rs187780276	G368S	0.45
UCEC	chrX	152967207	Missense_Mutation	novel	P613S	0.45
UCEC	chrX	152918024	Intron	novel		0.41
UCEC	chrX	152932954	Silent	rs782786998	I367I	0.41
UCEC	chrX	152914808	Nonsense_Mutation	NA	Q45*	0.39
UCEC	chrX	152928658	Missense_Mutation	novel	M304T	0.26
UCEC	chrX	152945424	Missense_Mutation	rs782412570	G456R	0.24
UCEC	chrX	152938100	Missense_Mutation	novel	V382A	0.35
UCEC	chrX	152931689	Missense_Mutation	novel	K311R	0.28
UCEC	chrX	152922226	Missense_Mutation	novel	A236D	0.29
UCEC	chrX	152914781	Missense_Mutation	NA	K36E	0.16
UCEC	chrX	152969382	Missense_Mutation	novel	R623S	0.31
UCEC	chrX	152914709	Splice_Site	novel	X12_splice	0.36
UCEC	chrX	152918002	Intron	novel		0.18
UCEC	chrX	152965472	Missense_Mutation	rs781953510	Y581H	0.34
UCEC	chrX	152922241	Missense_Mutation	novel	T241I	0.4
UCEC	chrX	152970504	Missense_Mutation	NA	T678I	0.28
UCEC	chrX	152917137	Silent	novel	P77P	0.34
UCEC	chrX	152938164	Splice_Site	novel	X403_splice	0.51
UCEC	chrX	152915182	Missense_Mutation	novel	A68D	0.42
UCEC	chrX	152931773	Missense_Mutation	novel	A339V	0.49

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	AMP	0.4556	0.024369
DLBC	AMP	0.1458	0.24013
HNSC	AMP	0.2146	0.0095371
KIRC	AMP	0.0417	0.12739
LIHC	AMP	0.1486	0.011319
LUSC	AMP	0.1677	0.08275
PAAD	AMP	0.0761	0.041079
READ	AMP	0.1455	0.14805
STAD	AMP	0.1111	0.0021069
TGCT	DEL	0.0667	0.08422
THCA	DEL	0	0.21991
UCS	DEL	0.2857	0.063955

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0033	Kaplan-Meier Survival Analysis
ACC	0.0065	Kaplan-Meier Survival Analysis
HNSC	0.018	Kaplan-Meier Survival Analysis
COAD	0.045	Kaplan-Meier Survival Analysis
PAAD	0.00016	Kaplan-Meier Survival Analysis
LAML	0.044	Kaplan-Meier Survival Analysis
KICH	0.0066	Kaplan-Meier Survival Analysis
UCEC	0.036	Kaplan-Meier Survival Analysis
GBM	0.032	Kaplan-Meier Survival Analysis
LUAD	0.005	Kaplan-Meier Survival Analysis
UVM	0.00011	Kaplan-Meier Survival Analysis

Drugs

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000147394 (Gene tree)
Gene ID: 7739
Gene Symbol: ZNF185
Alias: SCELL
Full Name: zinc finger protein 185 with LIM domain
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 75,350 bases
Position: chrX:152,898,132-152,973,481
Accession: 12976
RBP type: non-canonical RBP
Summary: Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a LIM-domain zinc finger protein. The LIM domain is composed of two contiguous zinc finger domains, separated by a two-amino acid residue hydrophobic linker. The LIM domain mediates protein:protein interactions. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, May 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000370268	ZNF185-204	4305	XM_005274738	ENSP00000359291	689 (aa)	XP_005274795	O15231
ENST00000535861	ZNF185-211	4421	XM_005274730	ENSP00000440847	721 (aa)	XP_005274787	O15231
ENST00000436731	ZNF185-207	2120	-	ENSP00000391272	552 (aa)	-	H7BZT5
ENST00000370270	ZNF185-205	2166	-	ENSP00000359293	721 (aa)	-	O15231
ENST00000447792	ZNF185-208	554	-	ENSP00000401766	185 (aa)	-	H7C1R1
ENST00000318529	ZNF185-202	3878	-	ENSP00000313919	468 (aa)	-	O15231
ENST00000426821	ZNF185-206	3545	-	ENSP00000409121	448 (aa)	-	H0Y704
ENST00000454925	ZNF185-210	3191	-	ENSP00000392984	327 (aa)	-	O15231
ENST00000324823	ZNF185-203	3597	-	ENSP00000325307	452 (aa)	-	O15231
ENST00000449285	ZNF185-209	4328	XM_005274737	ENSP00000395228	690 (aa)	XP_005274794	O15231
ENST00000318504	ZNF185-201	4148	XM_005274744	ENSP00000312782	630 (aa)	XP_005274801	O15231
ENST00000539731	ZNF185-212	4334	XM_005274735	ENSP00000444367	692 (aa)	XP_005274792	O15231

Gene Model

Click here to download ENSG00000147394's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000147394's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005737	cytoplasm	-	IEA	Component
GO:0005925	focal adhesion	-	IEA	Component
GO:0008270	zinc ion binding	9268636.	TAS	Function
GO:0015629	actin cytoskeleton	-	IEA	Component
GO:0051015	actin filament binding	-	IEA	Function

EuRBPDB

Note: to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Gene Ontology

Note: Click here to get the extension of tumor abbreviations.

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742

Note: to get the extension of tumor abbreviations.